Compounds > fosmidomycin-monosodium-salt

fosmidomycin-monosodium-salt and Malaria--Falciparum

fosmidomycin-monosodium-salt has been researched along with Malaria--Falciparum* in 1 studies

Other Studies

1 other study(ies) available for fosmidomycin-monosodium-salt and Malaria--Falciparum

Article	Year
MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria. Journal of medicinal chemistry, 2018, 10-11, Volume: 61, Issue:19 Severe malaria due to Plasmodium falciparum remains a significant global health threat. DXR, the second enzyme in the MEP pathway, plays an important role to synthesize building blocks for isoprenoids. This enzyme is a promising drug target for malaria due to its essentiality as well as its absence in humans. In this study, we designed and synthesized a series of α,β-unsaturated analogues of fosmidomycin, a natural product that inhibits DXR in P. falciparum. All compounds were evaluated as inhibitors of P. falciparum. The most promising compound, 18a, displays on-target, potent inhibition against the growth of P. falciparum (IC Topics: Aldose-Ketose Isomerases; Animals; Antimalarials; Female; Fosfomycin; Malaria, Falciparum; Mice; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship	2018

Article

Year

MEPicides: α,β-Unsaturated Fosmidomycin Analogues as DXR Inhibitors against Malaria.

Journal of medicinal chemistry, 2018, 10-11, Volume: 61, Issue:19

Severe malaria due to Plasmodium falciparum remains a significant global health threat. DXR, the second enzyme in the MEP pathway, plays an important role to synthesize building blocks for isoprenoids. This enzyme is a promising drug target for malaria due to its essentiality as well as its absence in humans. In this study, we designed and synthesized a series of α,β-unsaturated analogues of fosmidomycin, a natural product that inhibits DXR in P. falciparum. All compounds were evaluated as inhibitors of P. falciparum. The most promising compound, 18a, displays on-target, potent inhibition against the growth of P. falciparum (IC

Topics: Aldose-Ketose Isomerases; Animals; Antimalarials; Female; Fosfomycin; Malaria, Falciparum; Mice; Plasmodium falciparum; Prodrugs; Structure-Activity Relationship

2018