fosfomycin and Pneumonia--Viral

We report two cases of severe bronchopneumonia due to influenza A (H3N2) virus. The severity of the disease necessitated initiation of empiric therapy based on the present illness and clinical data on admission. Both patients were improved by artificial ventilation with positive end-expiratory pressures and administration of broad spectrum antibiotics and corticosteroids before confirming the diagnosis of viral bronchopneumonia using viral culture and serological tests. Within 24 hours, influenza A (H3N2) virus was identified by amplification of the pathogen genes by reverse transcription polymerase chain reaction (RT-PCR) using the stored bronchoalveolar lavage (BAL) fluids of both cases. This suggests that a combination of detection methods of pathogens using RT-PCR and BAL fluid will facilitate determination of rational treatment aimed at influenza A virus.

Topics: Aged; Antibiotic Prophylaxis; Betamethasone; Bronchoalveolar Lavage Fluid; Bronchopneumonia; Cephalosporins; Clindamycin; Combined Modality Therapy; Drug Therapy, Combination; Fosfomycin; Humans; Influenza A virus; Influenza A Virus, H3N2 Subtype; Male; Methylprednisolone; Middle Aged; Minocycline; Pneumonia, Viral; Positive-Pressure Respiration; Respiration, Artificial; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral