fosfomycin and Ovarian-Neoplasms

fosfomycin has been researched along with Ovarian-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for fosfomycin and Ovarian-Neoplasms

Article	Year
[Determination of urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion as a parameter of nephrotoxicity due to cis-platin and the effect of fosfomycin (FOM) on its nephrotoxicity]. Nihon Sanka Fujinka Gakkai zasshi, 1986, Volume: 38, Issue:11 CDDP is often dose-limited owing to its nephrotoxicity. Urinary NAG was measured to evaluate the nephrotoxicity of CDDP in 18 patients (DIV: 12 patients, Intra-Peritoneal: 6 patients) with or without Fosfomycin. The gradual increase in urinary NAG activity was noted on repeating the therapy. 24 hour NAG excretion was correlated with that of urinary beta 2-microglobulin. However, urinary NAG was not correlated with Ccr 24 or BUN. Though Ccr 24 and BUN were normal, urinary NAG and beta 2-microglobulin markedly increased during CDDP therapy. Fosfomycin administration significantly decreased urinary NAG, which was increased by CDDP. These results indicate that: The measurement of urinary NAG and beta 2-microglobulin are most useful in estimating the nephrotoxicity of CDDP. Fosfomycin decreases the nephrotoxicity of CDDP. Topics: Acetylglucosaminidase; Adult; Aged; Cisplatin; Drug Therapy, Combination; Female; Fosfomycin; Hexosaminidases; Humans; Kidney; Middle Aged; Ovarian Neoplasms	1986

Article

Year

[Determination of urinary N-acetyl-beta-D-glucosaminidase (NAG) excretion as a parameter of nephrotoxicity due to cis-platin and the effect of fosfomycin (FOM) on its nephrotoxicity].

Nihon Sanka Fujinka Gakkai zasshi, 1986, Volume: 38, Issue:11

CDDP is often dose-limited owing to its nephrotoxicity. Urinary NAG was measured to evaluate the nephrotoxicity of CDDP in 18 patients (DIV: 12 patients, Intra-Peritoneal: 6 patients) with or without Fosfomycin. The gradual increase in urinary NAG activity was noted on repeating the therapy. 24 hour NAG excretion was correlated with that of urinary beta 2-microglobulin. However, urinary NAG was not correlated with Ccr 24 or BUN. Though Ccr 24 and BUN were normal, urinary NAG and beta 2-microglobulin markedly increased during CDDP therapy. Fosfomycin administration significantly decreased urinary NAG, which was increased by CDDP. These results indicate that: The measurement of urinary NAG and beta 2-microglobulin are most useful in estimating the nephrotoxicity of CDDP. Fosfomycin decreases the nephrotoxicity of CDDP.

Topics: Acetylglucosaminidase; Adult; Aged; Cisplatin; Drug Therapy, Combination; Female; Fosfomycin; Hexosaminidases; Humans; Kidney; Middle Aged; Ovarian Neoplasms

1986