fosfomycin and Haemophilus-Infections

effects of Fosfomycin (FOM) nebulizer therapy were studied in patients with chronic sinusitis.. about 28 patients with chronic sinusitis were administered 2 ml of FOM sodium (3% w/v) by nebulizer three times per week for 4 weeks. Levels of IL-1 beta, IL-6, IL-8, and TNF-alpha in nasal lavage were also measured before and at the end of treatment.. the overall efficacy of this treatment on the basis of both subjective and objective symptoms, was 'excellent' for 28.6%, 'good' for 10.7%, 'fair' for 39.4%, and yield 'no change' for 21.4% of the patients. Both IL-1 beta and IL-6 concentrations were significantly decreased after treatment. Although the IL-8 level did not significantly decrease, it seems to be related to the overall efficacy. TNF-alpha was not detected in all of the samples.. FOM nebulization therapy is highly effective in treatment for chronic sinusitis, and efficacy may be due to an immunomodulatory mechanism, as well as its bactericidal effect.

Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Drug Administration Schedule; Exudates and Transudates; Female; Fosfomycin; Haemophilus Infections; Humans; Interleukins; Male; Middle Aged; Nebulizers and Vaporizers; Sinusitis; Streptococcal Infections; Treatment Outcome; Tumor Necrosis Factor-alpha

Acute osteomyelitis of the clavicle accounts for less than 3% of osteomyelitis cases, with its usual location in the middle third. It may be hematogenous, due to contiguity, or secondary to catheterization of the subclavian vein or neck surgery. The diagnosis is often delayed, and clinical symptoms may simulate obstetric brachial plexus palsy in young children. We report a new case of osteomyelitis of the clavicle in a 30-day-old newborn.

Topics: Abscess; Administration, Oral; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Catheterization, Central Venous; Cefotaxime; Clavicle; Female; Fever of Unknown Origin; Follow-Up Studies; Fosfomycin; Fractures, Spontaneous; Haemophilus Infections; Haemophilus influenzae; Humans; Infant; Infant, Newborn; Infectious Disease Transmission, Vertical; Infusions, Intravenous; Male; Osteomyelitis; Pregnancy; Pregnancy Complications, Infectious; Radionuclide Imaging; Sepsis; Streptococcal Infections; Ultrasonography

Topics: Drug Therapy, Combination; Endocarditis, Bacterial; Female; Fosfomycin; Gentamicins; Haemophilus Infections; Humans; Middle Aged

Haemophilus influenzae is an important pathogen in respiratory infections in children and often is implicated in otitis media. It is sensitive in vitro to a number of antibiotics, some of which are used clinically for the treatment of such infections. We have checked the in vitro sensitivity of a type b strain of H. influenzae. When tested in Levinthal's broth prepared with laked rabbit blood, the culture was most sensitive to tetracycline, ampicillin and penicillin and was somewhat less sensitive to cephalothin, fosfomycin, cephaloridine, and chloramphenicol. However, when this same strain was used to infect mice, fosfomycin was more active than ampicillin, tetracycline, chloramphenicol, penicillin or the cephalosporins.

Topics: Ampicillin; Animals; Anti-Bacterial Agents; Cephaloridine; Cephalothin; Chloramphenicol; Fosfomycin; Haemophilus Infections; Haemophilus influenzae; Injections, Subcutaneous; Mice; Penicillins; Tetracycline

Topics: Ampicillin; Anti-Bacterial Agents; Carbenicillin; Cephalosporins; Chloramphenicol; Cloxacillin; Fosfomycin; Gentamicins; Haemophilus Infections; Humans; Methicillin; Penicillin G; Polymyxins; Pseudomonas Infections; Respiratory Tract Infections; Sepsis; Staphylococcal Infections; Streptococcal Infections