fosfomycin and Fractures--Bone

Fosfomycin has been used in the treatment of 99 patients suffering from varying kinds of osseous processes and divided into 2 groups, one of 60 patients who were not operated on, and another of 39 who were operated. A treatment only with fosfomycin was tried initially by intravenous infusion (8-16 g/day during 2-4 days), then by the intramuscular route (2-8 g/day during 2-6 days) and finishing with treatment by the oral route (2-4 g/day during 2-6 days). The results have been excellent, all cases progressing with no septic complications. As for secondary effects, we have had only one case in which a rash appeared at the end of treatment. Intravenous infusion has been well tolerated with no sign of phlebitis in any patient.

Topics: Administration, Oral; Adolescent; Adult; Aged; Anti-Bacterial Agents; Child; Female; Fosfomycin; Fractures, Bone; Humans; Injections, Intramuscular; Injections, Intravenous; Male; Middle Aged; Osteomyelitis; Surgical Wound Infection; Wounds and Injuries