fosfomycin has been researched along with Endophthalmitis* in 2 studies
2 other study(ies) available for fosfomycin and Endophthalmitis
| Article | Year |
|---|---|
[Bacterial endophthalmitis: treatment with a combination of fosfomycin and pefloxacin apropos of 9 cases].
Topics: Adult; Aged; Aged, 80 and over; Bacterial Infections; Drug Therapy, Combination; Endophthalmitis; Female; Fosfomycin; Humans; Male; Middle Aged; Pefloxacin | 1989 |
[Diffusion of fosfomycin into the human and rabbit eye (aqueous humor and vitreous body)].
The intraocular distribution of fosfomycin was studied in 32 patients undergoing cataract surgery and in 8 rabbits after experimental infection of one eye by Staphylococcus aureus. Concentrations found 1 to 6 hours after termination of a 4 g fosfomycin infusion ranged from 14 to 18.8 mg/l in the aqueous humor and 8 to 12.5 mg/l in the vitreous body. These levels are higher than the MICs for 80 to 90% of the bacteria responsible for endophthalmitis. In each rabbit, the fosfomycin concentration in the infected eye as compared to the healthy eye was increased 2.5 to 5--fold for the aqueous humor and 4.9 to 19.2--fold for the vitreous body. Fosfomycin, in association with a third generation cephalosporin (ceftriaxone) or one of the new quinolones (pefloxacin) can be recommended for the prevention or early treatment of endophthalmitis. Topics: Adolescent; Adult; Aged; Animals; Aqueous Humor; Diffusion; Endophthalmitis; Fosfomycin; Humans; Middle Aged; Rabbits; Staphylococcal Infections; Time Factors; Vitreous Body | 1986 |