fosfomycin and Cerebrospinal-Fluid-Otorrhea

A case of post-traumatic meningitis with otorrhea due to Staphylococcus aureus was successfully treated with a cefotaxim-fosfomycin (CTX-FOS) combination. Serial samples of CSF leaking from the ear showed that maximal concentrations of CTX and FOS, 3.24 mg/l and 19.10 mg/l respectively, occurred one hour after the infusion of both antibiotics was terminated. For desacetyl-cefotaxim (D-CTX), maximal concentration (1.24 mg/l) occurred two hours later. These findings suggest that lumber puncture to control maximal penetration of CTX and FOS into CSF should be done one hour after infusion of both antibiotics.

Topics: Adult; Anti-Bacterial Agents; Cefotaxime; Cerebrospinal Fluid Otorrhea; Drug Resistance, Microbial; Fosfomycin; Humans; Male; Meningitis; Staphylococcal Infections