fosfomycin and Brain-Neoplasms

We report on a 81-year old patient who showed clinical signs of a shunt infection eight months after implantation of a ventriculo-atrial shunt system Heyer-Schulte. The reason was identified to be a massive infection with staphylococcus albus. Elimination of the infection was achieved by intravenous administration of fosfomycine and local instillation of gentamycin into the valve. The follow-up was uneventful for more than two years until the death of the patient in January 1987.

Topics: Aged; Brain Neoplasms; Cerebrospinal Fluid Shunts; Drug Therapy, Combination; Female; Fosfomycin; Gentamicins; Humans; Hydrocephalus; Injections, Intraventricular; Staphylococcal Infections; Surgical Wound Infection

A left parietal parasagittal meningioma was removed in a 67-year-old female patient. In the postoperative period she had a neurosurgical cerebral suppurating infection: subdural, epidural and epicranial, connected to the exterior by several fistulas. In the operative revision and after a culture, the germ causing the infection, E. coli, was isolated. Treatment was begun with 16 g of intravenous fosfomycin and 120 mg daily of 6-methylprednisolone intramuscularly, and this treatment cured the patient.

Topics: Aged; Anti-Bacterial Agents; Brain Neoplasms; Drug Therapy, Combination; Escherichia coli Infections; Female; Fosfomycin; Humans; Meningioma; Methylprednisolone; Surgical Wound Infection