fosfomycin and Brain-Diseases

fosfomycin has been researched along with Brain-Diseases* in 2 studies

Other Studies

2 other study(ies) available for fosfomycin and Brain-Diseases

Article	Year
Penetration of fosfomycin into the parenchyma of human brain: a case study in three patients. British journal of clinical pharmacology, 2002, Volume: 54, Issue:5 Topics: Adult; Aged; Anti-Bacterial Agents; Biological Transport; Blood-Brain Barrier; Brain Chemistry; Brain Diseases; Female; Fosfomycin; Humans; Male	2002
[Transfer of fosfomycin into the cerebrospinal fluid]. The Japanese journal of antibiotics, 1982, Volume: 35, Issue:11 After the fosfomycin (FOM) infusion, its levels in serum and cerebrospinal fluid (CSF) were repeatedly measured in 8 cases without meningitis. 1. The peak concentration of FOM in CSF was 15.5 micrograms/ml with the average of 10.3 micrograms/ml and was reached at 240 minutes with the average of 210 minutes after the infusion. The biological half life time of FOM in CSF was 2 to 6.5 hours. 2. The peak concentration in CSF was compared with it in serum. The average ratio was 4.3 per cent. Each area under the curve (AUC) of FOM concentration in CSF and serum was calculated and average of their ratio was 9.0 per cent. 3. In a case with middle cerebral artery aneurysm, FOM transferred into CSF with ease. The lowest diffusion into the CSF was shown in 2 cases of meningioma. In 3 cases of hypertensive intracerebral hemorrhage with intraventricular perforation, FOM moderately transferred into CSF. Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Brain Diseases; Female; Fosfomycin; Humans; Infusions, Parenteral; Male; Middle Aged; Postoperative Complications; Premedication	1982

Article

Year

Penetration of fosfomycin into the parenchyma of human brain: a case study in three patients.

British journal of clinical pharmacology, 2002, Volume: 54, Issue:5

Topics: Adult; Aged; Anti-Bacterial Agents; Biological Transport; Blood-Brain Barrier; Brain Chemistry; Brain Diseases; Female; Fosfomycin; Humans; Male

2002

[Transfer of fosfomycin into the cerebrospinal fluid].

The Japanese journal of antibiotics, 1982, Volume: 35, Issue:11

After the fosfomycin (FOM) infusion, its levels in serum and cerebrospinal fluid (CSF) were repeatedly measured in 8 cases without meningitis. 1. The peak concentration of FOM in CSF was 15.5 micrograms/ml with the average of 10.3 micrograms/ml and was reached at 240 minutes with the average of 210 minutes after the infusion. The biological half life time of FOM in CSF was 2 to 6.5 hours. 2. The peak concentration in CSF was compared with it in serum. The average ratio was 4.3 per cent. Each area under the curve (AUC) of FOM concentration in CSF and serum was calculated and average of their ratio was 9.0 per cent. 3. In a case with middle cerebral artery aneurysm, FOM transferred into CSF with ease. The lowest diffusion into the CSF was shown in 2 cases of meningioma. In 3 cases of hypertensive intracerebral hemorrhage with intraventricular perforation, FOM moderately transferred into CSF.

Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Brain Diseases; Female; Fosfomycin; Humans; Infusions, Parenteral; Male; Middle Aged; Postoperative Complications; Premedication

1982