fosfestrol and Heart-Arrest

Combined chemohormonal therapy of metastatic prostate cancer has not been previously evaluated in patients failing primary hormones (estrogens and/or orchiectomy). The combination of Adriamycin and high-dose diethylstilbestrol diphosphate (Stilphostrol) was studied in 19 heavily pretreated patients, to document toxicity and patient acceptability. Major toxicity was myelosuppression, cardiac failure and venous thrombosis. Clinical improvement was noted in 10/16 (63%) of evaluable patients. Patients with pre-existing cardiac disease or venous thrombosis are not suitable for this therapy.

Topics: Aged; Diethylstilbestrol; Doxorubicin; Drug Therapy, Combination; Heart Arrest; Humans; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Pilot Projects; Prognosis; Prostatic Neoplasms; Thrombophlebitis