foscarnet has been researched along with Sensitivity and Specificity in 13 studies
Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Phenotypic characterisation of the human cytomegalovirus (HCMV) pUL54 DNA polymerase is a useful tool for testing for mutations in the UL54 gene thought to render HCMV resistant to foscarnet." | 7.74 | Development and validation of a non-radioactive DNA polymerase assay for studying cytomegalovirus resistance to foscarnet. ( Alain, S; Ducancelle, A; Mazeron, MC; Petit, F; Sanson Le Pors, MJ, 2007) |
| "Phenotypic characterisation of the human cytomegalovirus (HCMV) pUL54 DNA polymerase is a useful tool for testing for mutations in the UL54 gene thought to render HCMV resistant to foscarnet." | 3.74 | Development and validation of a non-radioactive DNA polymerase assay for studying cytomegalovirus resistance to foscarnet. ( Alain, S; Ducancelle, A; Mazeron, MC; Petit, F; Sanson Le Pors, MJ, 2007) |
| " We attempted to detect cytomegalovirus DNA in 19 vitreous samples from patients with the acquired immunodeficiency syndrome (AIDS) who had untreated cytomegalovirus retinitis and in 40 vitreous samples from patients with AIDS who had been treated with systemic ganciclovir or foscarnet, or both." | 3.69 | A sensitive and specific polymerase chain reaction-based assay for the diagnosis of cytomegalovirus retinitis. ( Ai, E; Irvine, AR; Kuppermann, BD; Luckie, AP; Margolis, TP; McCann, JD; Schwartz, DM; Wong, MG, 1995) |
| "A rapid screening test for antiviral susceptibility to acyclovir and foscarnet was evaluated in 320 herpes simplex virus (HSV) isolates from 197 patients." | 3.69 | A rapid screen test for in vitro susceptibility of clinical herpes simplex virus isolates. ( Elbeik, T; Mills, J; Safrin, S, 1994) |
| "Antiviral susceptibility testing-flow cytometric analysis (AST-FCA), an application of flow cytometry in conjunction with cell culture, was developed to identify susceptibility of cytomegalovirus (CMV) isolates to the antiviral drugs ganciclovir (GCV) and foscarnet (PFA)." | 3.69 | Antiviral susceptibility testing-flow cytometric analysis (AST-FCA) for the detection of cytomegalovirus drug resistance. ( Biondo, FX; Kaplan, MH; Lipson, SM; Shepp, DH; Soni, M; Sun, T, 1997) |
| "Effective diagnosis and treatment of cytomegalovirus infection of the nervous system in AIDS patients has been limited by a lack of sensitive diagnostic measures." | 1.29 | Prognosis and response to therapy of cytomegalovirus encephalitis and meningomyelitis in AIDS. ( Cohen, BA, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 1 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tomasik, T | 1 |
| Opozda, A | 1 |
| Pietrzyk, JJ | 1 |
| Thi, TN | 1 |
| Deback, C | 1 |
| Malet, I | 1 |
| Bonnafous, P | 1 |
| Ait-Arkoub, Z | 1 |
| Agut, H | 1 |
| Ducancelle, A | 1 |
| Alain, S | 1 |
| Petit, F | 1 |
| Sanson Le Pors, MJ | 1 |
| Mazeron, MC | 1 |
| Zhang, H | 1 |
| Vrang, L | 1 |
| Bäckbro, K | 1 |
| Unge, T | 1 |
| Noréen, R | 1 |
| Oberg, B | 1 |
| McCann, JD | 1 |
| Margolis, TP | 1 |
| Wong, MG | 1 |
| Kuppermann, BD | 1 |
| Luckie, AP | 1 |
| Schwartz, DM | 1 |
| Irvine, AR | 1 |
| Ai, E | 1 |
| Safrin, S | 1 |
| Elbeik, T | 1 |
| Mills, J | 1 |
| Cohen, BA | 1 |
| Flood, J | 1 |
| Drew, WL | 1 |
| Miner, R | 1 |
| Jekic-McMullen, D | 1 |
| Shen, LP | 1 |
| Kolberg, J | 1 |
| Garvey, J | 1 |
| Follansbee, S | 1 |
| Poscher, M | 1 |
| Lipson, SM | 1 |
| Soni, M | 1 |
| Biondo, FX | 1 |
| Shepp, DH | 1 |
| Kaplan, MH | 1 |
| Sun, T | 1 |
| Stocchi, R | 1 |
| Ward, KN | 1 |
| Fanin, R | 1 |
| Baccarani, M | 1 |
| Apperley, JF | 1 |
| Boivin, G | 1 |
| Handfield, J | 1 |
| Toma, E | 1 |
| Lalonde, R | 1 |
| Bergeron, MG | 1 |
| Ba, BB | 1 |
| Corniot, AG | 1 |
| Ducint, D | 1 |
| Breilh, D | 1 |
| Grellet, J | 1 |
| Saux, MC | 1 |
| Cotarelo, M | 1 |
| Catalán, P | 1 |
| Sánchez-Carrillo, C | 1 |
| Menasalvas, A | 1 |
| Cercenado, E | 1 |
| Tenorio, A | 1 |
| Bouza, E | 1 |
1 review available for foscarnet and Sensitivity and Specificity
| Article | Year |
|---|---|
Management of human cytomegalovirus infection and disease after allogeneic bone marrow transplantation.
Topics: Acyclovir; Adolescent; Adult; Antigens, Viral; Antiviral Agents; Bone Marrow Transplantation; Child; | 1999 |
12 other studies available for foscarnet and Sensitivity and Specificity
| Article | Year |
|---|---|
[Cytomegalovirus infection--diagnostic and therapeutic difficulties in neonatal intensive care unit].
Topics: Antiviral Agents; Cross-Sectional Studies; Cytomegalovirus Infections; Foscarnet; Ganciclovir; Human | 2010 |
Rapid determination of antiviral drug susceptibility of herpes simplex virus types 1 and 2 by real-time PCR.
Topics: Acyclovir; Animals; Antiviral Agents; Chlorocebus aethiops; DNA, Viral; Drug Resistance, Viral; Fosc | 2006 |
Development and validation of a non-radioactive DNA polymerase assay for studying cytomegalovirus resistance to foscarnet.
Topics: Antiviral Agents; Catalytic Domain; Colorimetry; Cytomegalovirus; Digoxigenin; DNA-Directed DNA Poly | 2007 |
Enzymatic properties and sensitivity to inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with Glu-138-->Arg and Tyr-188-->His mutations.
Topics: Amino Acids; Antiviral Agents; Base Sequence; Benzodiazepines; Benzoxazoles; Binding, Competitive; D | 1994 |
A sensitive and specific polymerase chain reaction-based assay for the diagnosis of cytomegalovirus retinitis.
Topics: AIDS-Related Opportunistic Infections; Base Sequence; Cytomegalovirus; Cytomegalovirus Retinitis; DN | 1995 |
A rapid screen test for in vitro susceptibility of clinical herpes simplex virus isolates.
Topics: Acyclovir; Animals; Drug Resistance, Microbial; Evaluation Studies as Topic; Foscarnet; Herpes Genit | 1994 |
Prognosis and response to therapy of cytomegalovirus encephalitis and meningomyelitis in AIDS.
Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Base Sequence; Cerebrospi | 1996 |
Diagnosis of cytomegalovirus (CMV) polyradiculopathy and documentation of in vivo anti-CMV activity in cerebrospinal fluid by using branched DNA signal amplification and antigen assays.
Topics: Antigens, Viral; Antiviral Agents; Cells, Cultured; Cytomegalovirus; Cytomegalovirus Infections; Cyt | 1997 |
Antiviral susceptibility testing-flow cytometric analysis (AST-FCA) for the detection of cytomegalovirus drug resistance.
Topics: Antiviral Agents; Cells, Cultured; Cytomegalovirus; Dose-Response Relationship, Drug; Flow Cytometry | 1997 |
Expression of the late cytomegalovirus (CMV) pp150 transcript in leukocytes of AIDS patients is associated with a high viral DNA load in leukocytes and presence of CMV DNA in plasma.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections | 1999 |
Determination of phosphonoformate (foscarnet) in calf and human serum by automated solid-phase extraction and high-performance liquid chromatography with amperometric detection.
Topics: Animals; Antiviral Agents; Calibration; Cattle; Chromatography, High Pressure Liquid; Electrochemist | 1999 |
Cytopathic effect inhibition assay for determining the in-vitro susceptibility of herpes simplex virus to antiviral agents.
Topics: Acyclovir; Antiviral Agents; Foscarnet; Herpes Simplex; Herpesvirus 1, Human; Herpesvirus 2, Human; | 1999 |