foscarnet has been researched along with Retinal Detachment in 19 studies
Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
Retinal Detachment: Separation of the inner layers of the retina (neural retina) from the pigment epithelium. Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. It may occur after an uncomplicated cataract extraction, but it is seen more often if vitreous humor has been lost during surgery. (Dorland, 27th ed; Newell, Ophthalmology: Principles and Concepts, 7th ed, p310-12).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To study the effects of intravitreal foscarnet and the clinical differences between varicella zoster virus (VZV) and herpes simplex virus (HSV) induced acute retinal necrosis (ARN)." | 7.76 | Acute retinal necrosis: the effects of intravitreal foscarnet and virus type on outcome. ( Graham, EM; Laidlaw, DA; Pavesio, CE; Stanford, MR; Williamson, TH; Wong, R, 2010) |
| "This study evaluated intravitreous and plasma ganciclovir and foscarnet concentrations after intravenous administration in AIDS patients with cytomegalovirus (CMV) retinitis and retinal detachment." | 7.69 | Intravitreous and plasma concentrations of ganciclovir and foscarnet after intravenous therapy in patients with AIDS and cytomegalovirus retinitis. ( Arevalo, JF; Bergeron-Lynn, G; Capparelli, EV; Connor, JD; Freeman, WR; Gambertoglio, J; Garcia, RF; Gonzalez, C; Kirsch, LS; Quiceno, JI, 1995) |
| "Retinal detachment was not associated with the type of anticytomegalovirus therapy (intravenous foscarnet or ganciclovir) to which the patient was assigned." | 6.68 | Rhegmatogenous retinal detachment in patients with cytomegalovirus retinitis: the Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial. The Studies of Ocular Complications of AIDS (SOCA) Research Group in Collaboration with the AIDS Clinical Trials Group ( , 1997) |
| "To study the effects of intravitreal foscarnet and the clinical differences between varicella zoster virus (VZV) and herpes simplex virus (HSV) induced acute retinal necrosis (ARN)." | 3.76 | Acute retinal necrosis: the effects of intravitreal foscarnet and virus type on outcome. ( Graham, EM; Laidlaw, DA; Pavesio, CE; Stanford, MR; Williamson, TH; Wong, R, 2010) |
| "This study evaluated intravitreous and plasma ganciclovir and foscarnet concentrations after intravenous administration in AIDS patients with cytomegalovirus (CMV) retinitis and retinal detachment." | 3.69 | Intravitreous and plasma concentrations of ganciclovir and foscarnet after intravenous therapy in patients with AIDS and cytomegalovirus retinitis. ( Arevalo, JF; Bergeron-Lynn, G; Capparelli, EV; Connor, JD; Freeman, WR; Gambertoglio, J; Garcia, RF; Gonzalez, C; Kirsch, LS; Quiceno, JI, 1995) |
| "Retinal detachment was not associated with the type of anticytomegalovirus therapy (intravenous foscarnet or ganciclovir) to which the patient was assigned." | 2.68 | Rhegmatogenous retinal detachment in patients with cytomegalovirus retinitis: the Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial. The Studies of Ocular Complications of AIDS (SOCA) Research Group in Collaboration with the AIDS Clinical Trials Group ( , 1997) |
| "CMV-related retinal detachment is treated surgically." | 2.40 | Cytomegalovirus retinitis in patients with acquired immune deficiency syndrome. ( Au Eong, KG; Beatty, S; Charles, SJ, 1999) |
| "Retinal detachment is the main complication." | 1.32 | [Acute retinal necrosis: clinical presentation, treatment, and prognosis in a series of 22 patients]. ( Laroche, L; Larricart, P; Metge, F; Monin, C; Morel, C; Roman, S; Scheer, S, 2004) |
| "Retinal detachment was seen in 14 patients (relative frequency, 19." | 1.29 | Retinal detachment in patients with acquired immunodeficiency syndrome. ( Bogner, JR; Geier, SA; Goebel, FD; Klauss, V; Sadri, I; Schmidt-Kittler, H, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (52.63) | 18.2507 |
| 2000's | 3 (15.79) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 1 (5.26) | 2.80 |
| Authors | Studies |
|---|---|
| Spaide, RF | 2 |
| Byun, SS | 1 |
| Ong, SS | 1 |
| Postel, EA | 1 |
| Le, TD | 1 |
| Weisbrod, D | 1 |
| Mandelcorn, ED | 1 |
| Xu, K | 1 |
| Chin, EK | 1 |
| Mahajan, VB | 1 |
| Almeida, DR | 1 |
| Kim, SJ | 1 |
| Lo, WR | 1 |
| Wong, R | 1 |
| Pavesio, CE | 1 |
| Laidlaw, DA | 1 |
| Williamson, TH | 1 |
| Graham, EM | 1 |
| Stanford, MR | 1 |
| Kobayashi, R | 1 |
| Takanashi, K | 1 |
| Suzuki, D | 1 |
| Nasu, T | 1 |
| Uetake, K | 1 |
| Matsumoto, Y | 1 |
| Morel, C | 1 |
| Metge, F | 1 |
| Roman, S | 1 |
| Scheer, S | 1 |
| Larricart, P | 1 |
| Monin, C | 1 |
| Laroche, L | 1 |
| Arevalo, JF | 1 |
| Gonzalez, C | 1 |
| Capparelli, EV | 1 |
| Kirsch, LS | 1 |
| Garcia, RF | 1 |
| Quiceno, JI | 2 |
| Connor, JD | 1 |
| Gambertoglio, J | 1 |
| Bergeron-Lynn, G | 1 |
| Freeman, WR | 2 |
| Geier, SA | 1 |
| Klauss, V | 1 |
| Bogner, JR | 1 |
| Schmidt-Kittler, H | 1 |
| Sadri, I | 1 |
| Goebel, FD | 1 |
| Friedberg, DN | 1 |
| Berry, C | 1 |
| Behette, M | 1 |
| Fullerton, SC | 1 |
| Munguia, D | 1 |
| Dodds, EM | 1 |
| Lowder, CY | 1 |
| Foster, RE | 1 |
| Avery, RK | 1 |
| Prayson, RA | 1 |
| Martin, DF | 1 |
| Teich, SA | 2 |
| Katz, A | 1 |
| Toth, I | 1 |
| Weinberg, DV | 2 |
| Lyon, AT | 1 |
| Moorthy, RS | 1 |
| Berger, BB | 1 |
| Minturn, JT | 1 |
| Kumar, S | 1 |
| Rao, NA | 1 |
| Fowell, SM | 1 |
| Loose, IA | 1 |
| Jampol, LM | 1 |
| Althaus, C | 1 |
| Loeffler, KU | 1 |
| Schimkat, M | 1 |
| Hudde, T | 1 |
| Sundmacher, R | 1 |
| Au Eong, KG | 1 |
| Beatty, S | 1 |
| Charles, SJ | 1 |
| Assi, AC | 1 |
| Lightman, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Foscarnet-Ganciclovir CMV Retinitis Trial[NCT00000136] | Phase 3 | 234 participants (Actual) | Interventional | 1990-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00000136)
Timeframe: All patients enrolled will be followed until a common study closing date, which was chosen to provide a minimum of 1 year of follow-up for all patients enrolled in the trial.
| Intervention | participants (Number) |
|---|---|
| Foscarnet | 107 |
| Ganciclovir | 127 |
1 review available for foscarnet and Retinal Detachment
| Article | Year |
|---|---|
Cytomegalovirus retinitis in patients with acquired immune deficiency syndrome.
Topics: Anti-HIV Agents; CD4 Lymphocyte Count; Cidofovir; Cytomegalovirus Retinitis; Cytosine; Foscarnet; Ga | 1999 |
1 trial available for foscarnet and Retinal Detachment
| Article | Year |
|---|---|
Rhegmatogenous retinal detachment in patients with cytomegalovirus retinitis: the Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial. The Studies of Ocular Complications of AIDS (SOCA) Research Group in Collaboration with the AIDS Clinical Trials Group
Topics: Adolescent; Adult; Age Factors; AIDS-Related Opportunistic Infections; Antiviral Agents; CD4 Lymphoc | 1997 |
17 other studies available for foscarnet and Retinal Detachment
| Article | Year |
|---|---|
RECURRENT ACUTE RETINAL NECROSIS.
Topics: Acyclovir; Antiviral Agents; Child, Preschool; Female; Foscarnet; Humans; Retinal Detachment; Retina | 2022 |
Sudden Unilateral Decrease in Vision in a Healthy Middle-aged Man.
Topics: Antiviral Agents; Eye Infections, Viral; Fluorescein Angiography; Foscarnet; Herpes Simplex; Herpesv | 2018 |
Chorioretinitis with exudative retinal detachment secondary to varicella zoster virus.
Topics: Acyclovir; Administration, Oral; Antiviral Agents; Chorioretinitis; Drug Combinations; Exudates and | 2015 |
Intravitreal Foscarnet With Concurrent Silicone Oil Tamponade for Rhegmatogenous Retinal Detachment Secondary to Viral Retinitis.
Topics: Antiviral Agents; Combined Modality Therapy; Endotamponade; Eye Infections, Viral; Foscarnet; Humans | 2016 |
Acute retinal necrosis.
Topics: Acyclovir; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Eye Infections, Viral; Foscarnet | 2008 |
Acute retinal necrosis: the effects of intravitreal foscarnet and virus type on outcome.
Topics: Acyclovir; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Child; Eye Infections, Vira | 2010 |
Retinitis from cytomegalovirus during maintenance treatment for acute lymphoblastic leukemia.
Topics: Antimetabolites, Antineoplastic; Antiviral Agents; Child; Cytomegalovirus Retinitis; Drug Therapy, C | 2012 |
[Acute retinal necrosis: clinical presentation, treatment, and prognosis in a series of 22 patients].
Topics: Acyclovir; Adolescent; Adult; Aged; Antiviral Agents; Cytomegalovirus Retinitis; Drug Therapy, Combi | 2004 |
Intravitreous and plasma concentrations of ganciclovir and foscarnet after intravenous therapy in patients with AIDS and cytomegalovirus retinitis.
Topics: Acquired Immunodeficiency Syndrome; Adult; Cytomegalovirus Retinitis; Drug Therapy, Combination; Fem | 1995 |
Retinal detachment in patients with acquired immunodeficiency syndrome.
Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Cytomegalovirus Retinitis; Follow-Up Studie | 1994 |
Risk factors for development of rhegmatogenous retinal detachment in patients with cytomegalovirus retinitis.
Topics: AIDS-Related Opportunistic Infections; Cytomegalovirus Retinitis; Follow-Up Studies; Foscarnet; Ganc | 1993 |
Serous retinal detachments in a patient with clinically resistant cytomegalovirus retinitis.
Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus; Cytomega | 1996 |
Successful treatment of progressive outer retinal necrosis syndrome.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Antiviral Agents; Female; Foscarnet; Fundus Oc | 1996 |
Repair of retinal detachments due to herpes varicella-zoster virus retinitis in patients with acquired immune deficiency syndrome.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Foscarnet; Ganciclovir; Herpes Zoste | 1997 |
Management of varicella zoster virus retinitis in AIDS.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; AIDS-Related Opportunistic Infections; Analysi | 1997 |
Prophylactic argon laser coagulation for rhegmatogenous retinal detachment in AIDS patients with cytomegalovirus retinitis.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Retinitis; Foscarnet; Fundu | 1998 |
Clinicopathologic reports, case reports, and small case series: cytomegalovirus retinitis in patients with Good syndrome.
Topics: Agammaglobulinemia; Aged; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Retinitis; DNA, Viral; | 2002 |