Page last updated: 2024-10-27

foscarnet and Infections, Roseolovirus

foscarnet has been researched along with Infections, Roseolovirus in 35 studies

Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

Research Excerpts

ExcerptRelevanceReference
" We describe a patient who had severe encephalomyelitis, hypoglycorrhachia, and human herpesvirus 6 identified in his cerebrospinal fluid and serum and who recovered after treatment with foscarnet and ganciclovir."7.74Severe encephalomyelitis in an immunocompetent adult with chromosomally integrated human herpesvirus 6 and clinical response to treatment with foscarnet plus ganciclovir. ( Bhangoo, MS; Blackburn, BG; Caulfield, AK; Montoya, JG; Troy, SB; Yeom, K, 2008)
" We describe a patient who had severe encephalomyelitis, hypoglycorrhachia, and human herpesvirus 6 identified in his cerebrospinal fluid and serum and who recovered after treatment with foscarnet and ganciclovir."3.74Severe encephalomyelitis in an immunocompetent adult with chromosomally integrated human herpesvirus 6 and clinical response to treatment with foscarnet plus ganciclovir. ( Bhangoo, MS; Blackburn, BG; Caulfield, AK; Montoya, JG; Troy, SB; Yeom, K, 2008)
" Although prompt treatment with foscarnet stabilized encephalitis and there were no serious neurological sequelae, the patient developed both hyponatremia and natriuresis 11 days after intravenous administration of foscarnet."3.74[Salt-wasting nephropathy induced by foscarnet treatment for HHV-6 encephalitis in a hematopoietic stem cell transplant]. ( Akiyama, H; Ando, M; Koshida, A; Najima, Y; Ohashi, K; Sakamaki, H; Yamashita, T, 2008)
" Grade 3 or greater adverse events occurred in 9 of the 10 prophylactic PFA patients and in 7 of the 10 control patients who had clinical backgrounds similar to the study subjects and underwent SCT during the same period."2.77Safety of pre-engraftment prophylactic foscarnet administration after allogeneic stem cell transplantation. ( Hosokawa, K; Ishiyama, K; Katagiri, T; Kondo, Y; Nakao, S; Ohata, K; Takami, A; Yamazaki, H, 2012)
"Foscarnet is an effective treatment in HHV-7 associated myelitis."2.53Acute myelitis by human herpes virus 7 in an HIV-infected patient. ( Buisán Catevilla, J; Corral, I; Escobar-Villalba, A; Galán, JC; Martínez Ulloa, PL; Monreal Laguillo, E; Pérez Torre, P; Rodríguez-Domínguez, M; Sainz de la Maza, S, 2016)
"Foscarnet was restarted and continued until day +269 UCBT due to multiple HHV-6 recurrences with persistent hyponatremia."1.91Human herpesvirus 6 (HHV-6) associated permanent hyponatremia in umbilical cord blood transplant recipient. ( Gannamani, V; Nathan, S; Ustun, C; Varma, A, 2023)
"Treatment with foscarnet was effective in achieving improvement of symptoms and clearance of HHV-7 DNA in CSF in the cases of encephalitis and myelitis, while ganciclovir was ineffective in the case of encephalitis."1.48Molecular detection of human herpesvirus 7 DNA in cerebrospinal fluid from adult patients with neurological disorders. ( Corral, Í; Galán, JC; Kawiorski, MM; López-Martínez, MJ; Rodríguez, M; Sainz de la Maza, S, 2018)
"Treatment with foscarnet sodium and hypertonic saline was started with improvement of neurological condition within several days."1.39Severe hyponatremia caused by syndrome of inappropriate secretion of antidiuretic hormone developed as initial manifestation of human herpesvirus-6-associated acute limbic encephalitis after unrelated bone marrow transplantation. ( Abe, D; Iseki, T; Kawaguchi, T; Kawajiri, C; Nagao, Y; Nakaseko, C; Ohwada, C; Sakai, S; Sakaida, E; Shimizu, N; Sugita, Y; Takeda, Y; Takeuchi, M; Tsukamoto, S; Yamazaki, A; Yokote, K, 2013)
"Skin rash are common in immunocompromised patients, particularly after bone marrow transplantation."1.38Human Herpesvirus-6 cytopathic inclusions: an exceptional and recognizable finding on skin biopsy during HHV6 reactivation after autologous stem-cell transplantation. ( Battistella, M; Bouaziz, JD; Deau, B; Fornecker, L; Houhou, N; Janin, A; Legoff, J; Roux, J; Thieblemont, C, 2012)
"A 19-year-old man with Philadelphia chromosome-positive acute lymphoblastic leukemia received an allogeneic hematopoietic cell transplant with unrelated bone marrow."1.38Prolonged sinus tachycardia caused by human herpesvirus 6 (HHV6) encephalomyelitis after allogeneic bone marrow transplantation. ( Aimoto, M; Bingo, M; Hagihara, K; Hayashi, Y; Hino, M; Hirose, A; Inaba, A; Koh, H; Nakamae, H; Nakamae, M; Nakane, T; Nakao, Y; Nanno, S; Nishimoto, M; Okamura, H; Terada, Y; Yoshida, M; Yoshimura, T, 2012)
"Foscarnet treatment resulted both in viral load decline and disappearance of HHV-6-related bone marrow suppression and predisposition to severe infections."1.36Human herpesvirus 6-related pure red cell aplasia, secondary graft failure, and clinical severe immune suppression after allogeneic hematopoietic cell transplantation successfully treated with foscarnet. ( Dimitroulia, E; Lagadinou, ED; Liga, M; Marangos, M; Panos, G; Spyridonidis, A; Tiniakou, M; Tsakris, A; Tzouvara, E; Zoumbos, N, 2010)
"A 10-year-old girl with M2 acute myeloid leukemia underwent an unrelated cord blood transplantation in refractory first relapse."1.31Herpesvirus-6 encephalitis complicated by Wernicke-Korsakoff syndrome in a pediatric recipient of unrelated cord blood transplantation. ( Cañete, A; Carvajal, E; Castel, V; Fernández, JM; Verdeguer, A, 2001)

Research

Studies (35)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's12 (34.29)29.6817
2010's19 (54.29)24.3611
2020's4 (11.43)2.80

Authors

AuthorsStudies
Gannamani, V1
Varma, A1
Nathan, S1
Ustun, C1
Irie, K1
Hiramoto, N1
Yamaoka, K1
Fuckushima, S1
Ito, Y1
Toyama, K1
Honda, A1
Nakazaki, K1
Arai, S1
Kurokawa, M1
Ogata, M4
Oshima, K1
Ikebe, T2
Takano, K2
Kanamori, H1
Kondo, T1
Ueda, Y1
Mori, T1
Hashimoto, H1
Ogawa, H1
Eto, T1
Ueki, T1
Miyamoto, T1
Ichinohe, T1
Atsuta, Y1
Fukuda, T2
El-Jawahri, AR1
Schaefer, PW1
El Khoury, JB1
Martinez-Lage, M1
Corral, Í2
Sainz de la Maza, S2
Rodríguez, M1
Kawiorski, MM1
López-Martínez, MJ1
Galán, JC2
Zerr, DM1
Pantry, SN1
Medveczky, MM1
Arbuckle, JH1
Luka, J1
Montoya, JG2
Hu, J1
Renne, R1
Peterson, D1
Pritchett, JC1
Ablashi, DV2
Medveczky, PG1
Perissinotti, AJ1
Gulbis, A1
Shpall, EJ1
Howell, J1
Mordenti, P1
Zaffignani, E1
Immovilli, P1
Nobili, E1
Cavanna, L1
Escobar-Villalba, A1
Pérez Torre, P1
Rodríguez-Domínguez, M1
Monreal Laguillo, E1
Martínez Ulloa, PL1
Buisán Catevilla, J1
Agut, H2
Bonnafous, P1
Gautheret-Dejean, A1
Ongrádi, J1
Yoshikawa, T2
Stercz, B1
Troy, SB1
Blackburn, BG1
Yeom, K1
Caulfield, AK1
Bhangoo, MS1
Lagadinou, ED1
Marangos, M1
Liga, M1
Panos, G1
Tzouvara, E1
Dimitroulia, E1
Tiniakou, M1
Tsakris, A1
Zoumbos, N1
Spyridonidis, A1
Ishiyama, K2
Katagiri, T2
Hoshino, T1
Yoshida, T1
Yamaguchi, M1
Nakao, S2
Ohata, K1
Hosokawa, K1
Kondo, Y1
Yamazaki, H1
Takami, A1
Roux, J1
Battistella, M1
Fornecker, L1
Legoff, J1
Deau, B1
Houhou, N1
Bouaziz, JD1
Thieblemont, C1
Janin, A1
Nishimoto, M1
Nakamae, H1
Hayashi, Y1
Koh, H1
Nakane, T1
Yoshida, M1
Bingo, M1
Okamura, H1
Aimoto, M1
Nanno, S1
Yoshimura, T1
Inaba, A1
Hagihara, K1
Nakamae, M1
Hirose, A1
Nakao, Y1
Terada, Y1
Hino, M1
Satou, T1
Inoue, Y1
Ando, T1
Ikewaki, J1
Kohno, K1
Nishida, A1
Saburi, M1
Miyazaki, Y1
Ohtsuka, E1
Saburi, Y1
Kadota, J1
Kawaguchi, T1
Takeuchi, M1
Kawajiri, C1
Abe, D1
Nagao, Y1
Yamazaki, A1
Sugita, Y1
Tsukamoto, S1
Sakai, S1
Takeda, Y1
Ohwada, C1
Sakaida, E1
Shimizu, N1
Yokote, K1
Iseki, T1
Nakaseko, C1
De Bolle, L1
Hatse, S1
Verbeken, E1
De Clercq, E1
Naesens, L1
Dewhurst, S1
Oberacher-Velten, IM1
Jonas, JB1
Jünemann, A1
Schmidt, B1
Moriuchi, M1
Moriuchi, H1
Akhyani, N1
Fotheringham, J1
Yao, K1
Rashti, F1
Jacobson, S1
Capouya, JD1
Berman, DM1
Dumois, JA1
Maslin, J1
Bigaillon, C1
Froussard, F1
Enouf, V1
Nicand, E1
Pöhlmann, C1
Schetelig, J1
Reuner, U1
Bornhäuser, M1
Illmer, T1
Kiani, A1
Ehninger, G1
Jacobs, E1
Rohayem, J1
Chamberlain, MC1
Chowdhary, S1
Najima, Y1
Ohashi, K1
Ando, M1
Koshida, A1
Yamashita, T1
Akiyama, H1
Sakamaki, H1
Carvajal, E1
Verdeguer, A1
Fernández, JM1
Cañete, A1
Castel, V1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Assessment of Human Herpes Virus Reactivation 6 Post Autologous Stem Cells , Prospective, Open, Multicenter Study[NCT02090803]189 participants (Actual)Observational2012-08-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

9 reviews available for foscarnet and Infections, Roseolovirus

ArticleYear
[Human herpesvirus-6B encephalitis following allogeneic hematopoietic stem cell transplantation: how should it be managed?]
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2020, Volume: 61, Issue:8

    Topics: Encephalitis, Viral; Foscarnet; Hematopoietic Stem Cell Transplantation; Herpesvirus 6, Human; Human

2020
Human Herpesvirus 6B in the Transplant Recipient: When to Worry, When to Act.
    Journal of the Pediatric Infectious Diseases Society, 2018, Dec-26, Volume: 7, Issue:suppl_2

    Topics: Antiviral Agents; Encephalitis, Viral; Foscarnet; Ganciclovir; Herpesvirus 6, Human; Humans; Roseolo

2018
Acute myelitis by human herpes virus 7 in an HIV-infected patient.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2016, Volume: 77

    Topics: Adult; Antiviral Agents; CD4 Lymphocyte Count; Coinfection; DNA, Viral; Foscarnet; Herpesvirus 7, Hu

2016
Human Herpesviruses 6A, 6B, and 7.
    Microbiology spectrum, 2016, Volume: 4, Issue:3

    Topics: Antiviral Agents; Cidofovir; Cytosine; DNA, Viral; Foscarnet; Ganciclovir; Herpesvirus 6, Human; Her

2016
Roseolovirus-associated encephalitis in immunocompetent and immunocompromised individuals.
    Journal of neurovirology, 2017, Volume: 23, Issue:1

    Topics: Adult; Antiviral Agents; Child; Cord Blood Stem Cell Transplantation; Cytokines; Encephalitis, Viral

2017
[Human herpesvirus 6 encephalitis].
    Brain and nerve = Shinkei kenkyu no shinpo, 2010, Volume: 62, Issue:8

    Topics: Antiviral Agents; Double-Blind Method; Encephalitis, Viral; Foscarnet; Ganciclovir; Herpesvirus 6, H

2010
Deciphering the clinical impact of acute human herpesvirus 6 (HHV-6) infections.
    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2011, Volume: 52, Issue:3

    Topics: Antiviral Agents; Child; Child, Preschool; Cidofovir; Cytosine; DNA, Viral; Foscarnet; Ganciclovir;

2011
Human herpesvirus type 6 and human herpesvirus type 7 infections of the central nervous system.
    Herpes : the journal of the IHMF, 2004, Volume: 11 Suppl 2

    Topics: Antiviral Agents; Central Nervous System Viral Diseases; Foscarnet; Ganciclovir; Herpesvirus 6, Huma

2004
[Treatment of HHV-6 and HHV-7 infections].
    Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64 Suppl 3

    Topics: Antiviral Agents; Cidofovir; Cytosine; Drug Therapy, Combination; Foscarnet; Ganciclovir; Herpesviru

2006

Trials

2 trials available for foscarnet and Infections, Roseolovirus

ArticleYear
Preemptive therapy of human herpesvirus-6 encephalitis with foscarnet sodium for high-risk patients after hematopoietic SCT.
    Bone marrow transplantation, 2011, Volume: 46, Issue:6

    Topics: Adolescent; Adult; Chemoprevention; DNA, Viral; Encephalitis; Female; Foscarnet; Hematopoietic Stem

2011
Safety of pre-engraftment prophylactic foscarnet administration after allogeneic stem cell transplantation.
    Transplant infectious disease : an official journal of the Transplantation Society, 2012, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Antiviral Agents; DNA, Viral; Encephalitis, Viral; Female; Foscarnet; Hematopoiet

2012

Other Studies

24 other studies available for foscarnet and Infections, Roseolovirus

ArticleYear
Human herpesvirus 6 (HHV-6) associated permanent hyponatremia in umbilical cord blood transplant recipient.
    Transplant immunology, 2023, Volume: 76

    Topics: Cord Blood Stem Cell Transplantation; Female; Foscarnet; Herpesvirus 6, Human; Humans; Hyponatremia;

2023
Cerebrospinal fluid concentration of foscarnet in patients with HHV-6 encephalitis after haematopoietic stem cell transplantation.
    The Journal of antimicrobial chemotherapy, 2023, 06-01, Volume: 78, Issue:6

    Topics: Antiviral Agents; DNA, Viral; Encephalitis, Viral; Foscarnet; Hematopoietic Stem Cell Transplantatio

2023
Posterior reversible encephalopathy syndrome concurrent with human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2020, Volume: 26, Issue:2

    Topics: Antiviral Agents; Encephalitis, Viral; Foscarnet; Hematopoietic Stem Cell Transplantation; Herpesvir

2020
Clinical characteristics and outcome of human herpesvirus-6 encephalitis after allogeneic hematopoietic stem cell transplantation.
    Bone marrow transplantation, 2017, Volume: 52, Issue:11

    Topics: Adolescent; Antiviral Agents; Encephalitis, Viral; Foscarnet; Ganciclovir; Herpesvirus 6, Human; Hum

2017
Case 5-2018: A 63-Year-Old Man with Confusion after Stem-Cell Transplantation.
    The New England journal of medicine, 2018, Feb-15, Volume: 378, Issue:7

    Topics: Antiviral Agents; Autopsy; Confusion; Diagnosis, Differential; Fatal Outcome; Foscarnet; Graft vs Ho

2018
Molecular detection of human herpesvirus 7 DNA in cerebrospinal fluid from adult patients with neurological disorders.
    Journal of neurovirology, 2018, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA, Viral; Encephalitis, Viral; Femal

2018
Persistent human herpesvirus-6 infection in patients with an inherited form of the virus.
    Journal of medical virology, 2013, Volume: 85, Issue:11

    Topics: Adult; Antiviral Agents; Cohort Studies; DNA, Viral; Foscarnet; Ganciclovir; Herpesvirus 6, Human; H

2013
Characterizing human herpes virus 6 following hematopoietic stem cell transplantation.
    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners, 2015, Volume: 21, Issue:2

    Topics: Adolescent; Adult; Aged; Antiviral Agents; Child; Child, Preschool; DNA, Viral; Drug Therapy, Combin

2015
Human herpesvirus 6 encephalitis simulating brain metastases in a patient with advanced small-cell lung cancer.
    Chemotherapy, 2013, Volume: 59, Issue:5

    Topics: Antiviral Agents; Brain Neoplasms; Encephalitis, Viral; Foscarnet; Ganciclovir; Herpesvirus 6, Human

2013
Severe encephalomyelitis in an immunocompetent adult with chromosomally integrated human herpesvirus 6 and clinical response to treatment with foscarnet plus ganciclovir.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2008, Dec-15, Volume: 47, Issue:12

    Topics: Adult; Antiviral Agents; Cerebrospinal Fluid; Encephalomyelitis; Foscarnet; Ganciclovir; Herpesvirus

2008
Human herpesvirus 6-related pure red cell aplasia, secondary graft failure, and clinical severe immune suppression after allogeneic hematopoietic cell transplantation successfully treated with foscarnet.
    Transplant infectious disease : an official journal of the Transplantation Society, 2010, Volume: 12, Issue:5

    Topics: Adult; Antiviral Agents; Foscarnet; Graft Rejection; Hematopoietic Stem Cell Transplantation; Herpes

2010
Human Herpesvirus-6 cytopathic inclusions: an exceptional and recognizable finding on skin biopsy during HHV6 reactivation after autologous stem-cell transplantation.
    The American Journal of dermatopathology, 2012, Volume: 34, Issue:6

    Topics: Antiviral Agents; Biopsy; Cytopathogenic Effect, Viral; Exanthema; Foscarnet; Hematopoietic Stem Cel

2012
Prolonged sinus tachycardia caused by human herpesvirus 6 (HHV6) encephalomyelitis after allogeneic bone marrow transplantation.
    Internal medicine (Tokyo, Japan), 2012, Volume: 51, Issue:10

    Topics: Antiviral Agents; Bone Marrow Transplantation; Encephalitis, Viral; Foscarnet; Herpesvirus 6, Human;

2012
Foscarnet against human herpesvirus (HHV)-6 reactivation after allo-SCT: breakthrough HHV-6 encephalitis following antiviral prophylaxis.
    Bone marrow transplantation, 2013, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Aged; Antiviral Agents; Cohort Studies; Encephalitis, Viral; Foscarnet; Hematopoi

2013
Severe hyponatremia caused by syndrome of inappropriate secretion of antidiuretic hormone developed as initial manifestation of human herpesvirus-6-associated acute limbic encephalitis after unrelated bone marrow transplantation.
    Transplant infectious disease : an official journal of the Transplantation Society, 2013, Volume: 15, Issue:2

    Topics: Antiviral Agents; Bone Marrow Transplantation; Diagnosis, Differential; DNA, Viral; Female; Foscarne

2013
Human herpesvirus 6 infection arrests cord blood mononuclear cells in G(2) phase of the cell cycle.
    FEBS letters, 2004, Feb-27, Volume: 560, Issue:1-3

    Topics: Antiviral Agents; Cell Cycle; Cell Division; Cyclin A; Cyclin B; Cyclin-Dependent Kinases; DNA; Feta

2004
Bilateral optic neuropathy and unilateral tonic pupil associated with acute human herpesvirus 6 infection: a case report.
    Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2005, Volume: 243, Issue:2

    Topics: Adult; Antibodies, Viral; Antiviral Agents; Eye Infections, Viral; Foscarnet; Herpesvirus 6, Human;

2005
Efficacy of antiviral compounds in human herpesvirus-6-infected glial cells.
    Journal of neurovirology, 2006, Volume: 12, Issue:4

    Topics: Antiviral Agents; Astrocytes; Astrocytoma; Dose-Response Relationship, Drug; Foscarnet; Herpesvirus

2006
Mollaret's meningitis due to human herpesvirus 6 in an adolescent.
    Clinical pediatrics, 2006, Volume: 45, Issue:9

    Topics: Adolescent; Antiviral Agents; Female; Foscarnet; Herpesvirus 6, Human; Humans; Meningitis, Viral; Po

2006
Acute bilateral uveitis associated with an active human herpesvirus-6 infection.
    The Journal of infection, 2007, Volume: 54, Issue:4

    Topics: Acute Disease; Aged, 80 and over; Antiviral Agents; Aqueous Humor; Cerebrospinal Fluid; DNA, Viral;

2007
Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Jun-15, Volume: 44, Issue:12

    Topics: Antiviral Agents; Cidofovir; Cytosine; Drug Therapy, Combination; Encephalitis, Viral; Foscarnet; Gr

2007
Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6.
    Neurology, 2008, Feb-05, Volume: 70, Issue:6

    Topics: Antiviral Agents; Brain; Confusion; Diagnosis, Differential; DNA, Viral; Female; Foscarnet; Ganciclo

2008
[Salt-wasting nephropathy induced by foscarnet treatment for HHV-6 encephalitis in a hematopoietic stem cell transplant].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2008, Volume: 49, Issue:1

    Topics: Antiviral Agents; Encephalitis, Viral; Female; Foscarnet; Hematopoietic Stem Cell Transplantation; H

2008
Herpesvirus-6 encephalitis complicated by Wernicke-Korsakoff syndrome in a pediatric recipient of unrelated cord blood transplantation.
    Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Child; Combined Modality Therapy;

2001