foscarnet has been researched along with Eye Disorders in 4 studies
Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eleven clinical centers, a data coordinating center, and a fundus photograph reading center participated in a randomized, controlled, multicenter clinical trial comparing foscarnet and ganciclovir as primary therapy for previously untreated CMV retinitis in 240 patients with AIDS." | 9.08 | Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 5. Clinical features of cytomegalovirus retinitis at diagnosis. Studies of ocular complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group. ( , 1997) |
| "Eleven clinical centers, a data coordinating center, and a fundus photograph reading center participated in a randomized, controlled, multicenter clinical trial comparing foscarnet and ganciclovir as primary therapy for previously untreated CMV retinitis in 240 patients with AIDS." | 5.08 | Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 5. Clinical features of cytomegalovirus retinitis at diagnosis. Studies of ocular complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group. ( , 1997) |
| " We attempted to detect cytomegalovirus DNA in 19 vitreous samples from patients with the acquired immunodeficiency syndrome (AIDS) who had untreated cytomegalovirus retinitis and in 40 vitreous samples from patients with AIDS who had been treated with systemic ganciclovir or foscarnet, or both." | 3.69 | A sensitive and specific polymerase chain reaction-based assay for the diagnosis of cytomegalovirus retinitis. ( Ai, E; Irvine, AR; Kuppermann, BD; Luckie, AP; Margolis, TP; McCann, JD; Schwartz, DM; Wong, MG, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McCann, JD | 1 |
| Margolis, TP | 1 |
| Wong, MG | 1 |
| Kuppermann, BD | 1 |
| Luckie, AP | 1 |
| Schwartz, DM | 1 |
| Irvine, AR | 1 |
| Ai, E | 1 |
| Keijer, WJ | 1 |
| Burger, DM | 1 |
| Neuteboom, GH | 1 |
| Vrooland, JL | 1 |
| Meenhorst, PL | 1 |
| Koks, CH | 1 |
| Beijnen, JH | 1 |
| Yoshizumi, MO | 1 |
| Dessouki, A | 1 |
| Lee, DA | 1 |
| Lee, G | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Foscarnet-Ganciclovir CMV Retinitis Trial[NCT00000136] | Phase 3 | 234 participants (Actual) | Interventional | 1990-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00000136)
Timeframe: All patients enrolled will be followed until a common study closing date, which was chosen to provide a minimum of 1 year of follow-up for all patients enrolled in the trial.
| Intervention | participants (Number) |
|---|---|
| Foscarnet | 107 |
| Ganciclovir | 127 |
1 review available for foscarnet and Eye Disorders
| Article | Year |
|---|---|
Ocular complications of the acquired immunodeficiency syndrome. Focus on the treatment of cytomegalovirus retinitis with ganciclovir and foscarnet.
Topics: Acquired Immunodeficiency Syndrome; Cytomegalovirus Infections; Eye Diseases; Foscarnet; Ganciclovir | 1993 |
1 trial available for foscarnet and Eye Disorders
| Article | Year |
|---|---|
Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 5. Clinical features of cytomegalovirus retinitis at diagnosis. Studies of ocular complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Antiviral Agents; Cytomegalovirus Infections; | 1997 |
2 other studies available for foscarnet and Eye Disorders
| Article | Year |
|---|---|
A sensitive and specific polymerase chain reaction-based assay for the diagnosis of cytomegalovirus retinitis.
Topics: AIDS-Related Opportunistic Infections; Base Sequence; Cytomegalovirus; Cytomegalovirus Retinitis; DN | 1995 |
Determination of ocular toxicity in multiple applications of foscarnet iontophoresis.
Topics: Animals; Antiviral Agents; Eye; Eye Diseases; Foscarnet; Iontophoresis; Rabbits; Vitreous Body | 1997 |