Page last updated: 2024-10-27

foscarnet and Encephalitis, Viral

foscarnet has been researched along with Encephalitis, Viral in 38 studies

Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

Encephalitis, Viral: Inflammation of brain parenchymal tissue as a result of viral infection. Encephalitis may occur as primary or secondary manifestation of TOGAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS; PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.

Research Excerpts

ExcerptRelevanceReference
"Foscarnet was discontinued because of concern about its potential central nervous system toxicity."5.31Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient. ( Balfour, HH; Clark, HB; Holman, CJ; Julin, JE; Krivit, W; van Burik, JH; Webb, C, 2002)
"To evaluate the efficacy and safety of the foscarnet-ganciclovir combination in induction therapy (IT) and maintenance therapy (MT) for cytomegalovirus (CMV) central neurological disorders in HIV-infected patients."5.09Induction and maintenance therapy of cytomegalovirus central nervous system infection in HIV-infected patients. ( Anduze-Faris, BM; Boukli, N; Caumes, E; Costagliola, D; Fillet, AM; Gasnault, J; Gozlan, J; Katlama, C; Lancar, R; Leport, C; Livartowsky, J; Matheron, S; Salmon, D, 2000)
" Although prompt treatment with foscarnet stabilized encephalitis and there were no serious neurological sequelae, the patient developed both hyponatremia and natriuresis 11 days after intravenous administration of foscarnet."3.74[Salt-wasting nephropathy induced by foscarnet treatment for HHV-6 encephalitis in a hematopoietic stem cell transplant]. ( Akiyama, H; Ando, M; Koshida, A; Najima, Y; Ohashi, K; Sakamaki, H; Yamashita, T, 2008)
" Grade 3 or greater adverse events occurred in 9 of the 10 prophylactic PFA patients and in 7 of the 10 control patients who had clinical backgrounds similar to the study subjects and underwent SCT during the same period."2.77Safety of pre-engraftment prophylactic foscarnet administration after allogeneic stem cell transplantation. ( Hosokawa, K; Ishiyama, K; Katagiri, T; Kondo, Y; Nakao, S; Ohata, K; Takami, A; Yamazaki, H, 2012)
"We report a case of pseudorabies virus encephalitis and endophthalmitis, diagnosed 89 days after onset, confirmed with intraocular fluid metagenomic next generation sequencing (mNGS) after the result of two cerebrospinal fluid (CSF) mNGS tests were negative."1.91A case report of long-delayed diagnosis of pseudorabies virus encephalitis with endophthalmitis: lessons from metagenomic next generation sequencing. ( Fang, L; Li, L; Liang, B; Yan, C; Zhang, Y; Zhou, Y, 2023)
"Treatment with foscarnet was effective in achieving improvement of symptoms and clearance of HHV-7 DNA in CSF in the cases of encephalitis and myelitis, while ganciclovir was ineffective in the case of encephalitis."1.48Molecular detection of human herpesvirus 7 DNA in cerebrospinal fluid from adult patients with neurological disorders. ( Corral, Í; Galán, JC; Kawiorski, MM; López-Martínez, MJ; Rodríguez, M; Sainz de la Maza, S, 2018)
"A 19-year-old man with Philadelphia chromosome-positive acute lymphoblastic leukemia received an allogeneic hematopoietic cell transplant with unrelated bone marrow."1.38Prolonged sinus tachycardia caused by human herpesvirus 6 (HHV6) encephalomyelitis after allogeneic bone marrow transplantation. ( Aimoto, M; Bingo, M; Hagihara, K; Hayashi, Y; Hino, M; Hirose, A; Inaba, A; Koh, H; Nakamae, H; Nakamae, M; Nakane, T; Nakao, Y; Nanno, S; Nishimoto, M; Okamura, H; Terada, Y; Yoshida, M; Yoshimura, T, 2012)
"Foscarnet was discontinued because of concern about its potential central nervous system toxicity."1.31Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient. ( Balfour, HH; Clark, HB; Holman, CJ; Julin, JE; Krivit, W; van Burik, JH; Webb, C, 2002)
"An exacerbation of the myelitis, retinitis, encephalitis and colitis was observed and a cytomegalovirus infection diagnosed."1.31CMV complications in common variable immunodeficiency. ( Schmidt, RE; Werwitzke, S; Witte, T, 2000)
"A 10-year-old girl with M2 acute myeloid leukemia underwent an unrelated cord blood transplantation in refractory first relapse."1.31Herpesvirus-6 encephalitis complicated by Wernicke-Korsakoff syndrome in a pediatric recipient of unrelated cord blood transplantation. ( Cañete, A; Carvajal, E; Castel, V; Fernández, JM; Verdeguer, A, 2001)
"CMV viremia was present in 4 patients."1.29Cytomegalovirus ventriculoencephalitis in AIDS patients. ( Fernandez-Viladrich, P; Ferrer, I; Gudiol, F; Perez, JL; Podzamczer, D; Reñe, R; Salazar, A; Santin, M, 1995)

Research

Studies (38)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's10 (26.32)18.2507
2000's11 (28.95)29.6817
2010's13 (34.21)24.3611
2020's4 (10.53)2.80

Authors

AuthorsStudies
Irie, K1
Hiramoto, N1
Yamaoka, K1
Fuckushima, S1
Zhang, Y2
Fang, L1
Zhou, Y1
Liang, B1
Yan, C1
Li, L1
Ito, Y1
Toyama, K1
Honda, A1
Nakazaki, K1
Arai, S1
Kurokawa, M1
Ogata, M5
Oshima, K2
Ikebe, T2
Takano, K3
Kanamori, H1
Kondo, T2
Ueda, Y1
Mori, T2
Hashimoto, H1
Ogawa, H1
Eto, T2
Ueki, T2
Miyamoto, T1
Ichinohe, T1
Atsuta, Y1
Fukuda, T3
Moriuchi, Y1
Nakano, N1
Uoshima, N1
Nagafuji, K1
Yamasaki, S1
Shibasaki, Y1
Sakai, R1
Kato, K1
Choi, I1
Jo, Y1
Kako, S1
Corral, Í1
Sainz de la Maza, S1
Rodríguez, M1
Kawiorski, MM1
López-Martínez, MJ1
Galán, JC1
Baghban, A1
Malinis, M1
Zerr, DM1
Mordenti, P1
Zaffignani, E1
Immovilli, P1
Nobili, E1
Cavanna, L1
Ongrádi, J1
Ablashi, DV1
Yoshikawa, T2
Stercz, B1
Krishnan, P1
Ramadas, P1
Chakravarty, R1
Sah, B1
Hubacek, P1
Keslova, P1
Formankova, R1
Pochop, P1
Cinek, O1
Zajac, M1
Lochmanova, J1
Stary, J1
Sedlacek, P1
Baldwin, K1
Ishiyama, K1
Katagiri, T1
Ohata, K1
Hosokawa, K1
Kondo, Y1
Yamazaki, H1
Takami, A1
Nakao, S1
Nishimoto, M1
Nakamae, H1
Hayashi, Y1
Koh, H1
Nakane, T1
Yoshida, M1
Bingo, M1
Okamura, H1
Aimoto, M1
Nanno, S1
Yoshimura, T1
Inaba, A1
Hagihara, K1
Nakamae, M1
Hirose, A1
Nakao, Y1
Terada, Y1
Hino, M1
Satou, T1
Inoue, Y1
Ando, T1
Ikewaki, J1
Kohno, K1
Nishida, A1
Saburi, M1
Miyazaki, Y1
Ohtsuka, E1
Saburi, Y1
Kadota, J1
Julin, JE1
van Burik, JH1
Krivit, W1
Webb, C1
Holman, CJ1
Clark, HB1
Balfour, HH1
Nakamoto, BK1
Dorotheo, EU1
Biousse, V1
Tang, RA1
Schiffman, JS1
Newman, NJ1
Pöhlmann, C1
Schetelig, J1
Reuner, U1
Bornhäuser, M1
Illmer, T1
Kiani, A1
Ehninger, G1
Jacobs, E1
Rohayem, J1
Najima, Y1
Ohashi, K1
Ando, M1
Koshida, A1
Yamashita, T1
Akiyama, H1
Sakamaki, H1
Holida, MD1
Trigg, ME1
Rumelhart, SL1
Lee, NF1
Kook, H1
Peters, C1
Salazar, A1
Podzamczer, D1
Reñe, R1
Santin, M1
Perez, JL1
Ferrer, I1
Fernandez-Viladrich, P1
Gudiol, F1
Roedel, C1
Grob, R1
Ruef, C1
Huengsberg, M1
Stevenson, M1
Zaknun, D1
Zangerle, R1
Kapelari, K1
Fischer, H1
Sailer, M1
McIntosh, K1
Read, RC1
Vilar, FJ1
Smith, TL1
Cinque, P1
Cleator, GM1
Weber, T1
Monteyne, P1
Sindic, C1
Gerna, G1
van Loon, AM1
Klapper, PE1
Cole, PD1
Stiles, J1
Boulad, F2
Small, TN1
O'Reilly, RJ1
George, D2
Szabolcs, P1
Kiehn, TE2
Kernan, NA1
Tiacci, E1
Luppi, M1
Barozzi, P1
Gurdo, G1
Tabilio, A1
Ballanti, S1
Torelli, G1
Aversa, F1
Bethge, W1
Beck, R1
Jahn, G1
Mundinger, P1
Kanz, L1
Einsele, H1
Anduze-Faris, BM1
Fillet, AM1
Gozlan, J1
Lancar, R1
Boukli, N1
Gasnault, J1
Caumes, E1
Livartowsky, J1
Matheron, S1
Leport, C1
Salmon, D1
Costagliola, D1
Katlama, C1
Rubin, DI1
Witte, T1
Werwitzke, S1
Schmidt, RE1
Seo, SK1
Regan, A1
Cihlar, T1
Lin, DC1
Prasad, VK1
Polsky, B1
Carvajal, E1
Verdeguer, A1
Fernández, JM1
Cañete, A1
Castel, V1
Williams, IG1

Reviews

8 reviews available for foscarnet and Encephalitis, Viral

ArticleYear
[Human herpesvirus-6B encephalitis following allogeneic hematopoietic stem cell transplantation: how should it be managed?]
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2020, Volume: 61, Issue:8

    Topics: Encephalitis, Viral; Foscarnet; Hematopoietic Stem Cell Transplantation; Herpesvirus 6, Human; Human

2020
Ganciclovir and foscarnet dual-therapy for cytomegalovirus encephalitis: A case report and review of the literature.
    Journal of the neurological sciences, 2018, 05-15, Volume: 388

    Topics: Antiviral Agents; Cytomegalovirus Infections; Drug Therapy, Combination; Encephalitis, Viral; Female

2018
Human Herpesvirus 6B in the Transplant Recipient: When to Worry, When to Act.
    Journal of the Pediatric Infectious Diseases Society, 2018, Dec-26, Volume: 7, Issue:suppl_2

    Topics: Antiviral Agents; Encephalitis, Viral; Foscarnet; Ganciclovir; Herpesvirus 6, Human; Humans; Roseolo

2018
Roseolovirus-associated encephalitis in immunocompetent and immunocompromised individuals.
    Journal of neurovirology, 2017, Volume: 23, Issue:1

    Topics: Adult; Antiviral Agents; Child; Cord Blood Stem Cell Transplantation; Cytokines; Encephalitis, Viral

2017
[Human herpesvirus 6 encephalitis].
    Brain and nerve = Shinkei kenkyu no shinpo, 2010, Volume: 62, Issue:8

    Topics: Antiviral Agents; Double-Blind Method; Encephalitis, Viral; Foscarnet; Ganciclovir; Herpesvirus 6, H

2010
Progressive outer retinal necrosis presenting with isolated optic neuropathy.
    Neurology, 2004, Dec-28, Volume: 63, Issue:12

    Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Infection

2004
Diagnosis and clinical management of neurological disorders caused by cytomegalovirus in AIDS patients. European Union Concerted Action on Virus Meningitis and Encephalitis.
    Journal of neurovirology, 1998, Volume: 4, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Infections; Diagnostic Techniq

1998
Management of CMV disease in HIV infection.
    International journal of STD & AIDS, 1999, Volume: 10, Issue:4

    Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Cidofovir; Cytomegalovirus Infections; Cyto

1999

Trials

3 trials available for foscarnet and Encephalitis, Viral

ArticleYear
Effects of Prophylactic Foscarnet on Human Herpesvirus-6 Reactivation and Encephalitis in Cord Blood Transplant Recipients: A Prospective Multicenter Trial with an Historical Control Group.
    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2018, Volume: 24, Issue:6

    Topics: Adolescent; Adult; Aged; Antiviral Agents; DNA, Viral; Encephalitis, Viral; Female; Fetal Blood; Fos

2018
Safety of pre-engraftment prophylactic foscarnet administration after allogeneic stem cell transplantation.
    Transplant infectious disease : an official journal of the Transplantation Society, 2012, Volume: 14, Issue:1

    Topics: Adolescent; Adult; Antiviral Agents; DNA, Viral; Encephalitis, Viral; Female; Foscarnet; Hematopoiet

2012
Induction and maintenance therapy of cytomegalovirus central nervous system infection in HIV-infected patients.
    AIDS (London, England), 2000, Mar-31, Volume: 14, Issue:5

    Topics: Adult; Aged; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus; Cytomegalovir

2000

Other Studies

27 other studies available for foscarnet and Encephalitis, Viral

ArticleYear
Cerebrospinal fluid concentration of foscarnet in patients with HHV-6 encephalitis after haematopoietic stem cell transplantation.
    The Journal of antimicrobial chemotherapy, 2023, 06-01, Volume: 78, Issue:6

    Topics: Antiviral Agents; DNA, Viral; Encephalitis, Viral; Foscarnet; Hematopoietic Stem Cell Transplantatio

2023
A case report of long-delayed diagnosis of pseudorabies virus encephalitis with endophthalmitis: lessons from metagenomic next generation sequencing.
    BMC neurology, 2023, May-16, Volume: 23, Issue:1

    Topics: Acyclovir; Antiviral Agents; Aqueous Humor; Blindness; Delayed Diagnosis; DNA, Viral; Encephalitis,

2023
Posterior reversible encephalopathy syndrome concurrent with human herpesvirus-6B encephalitis after allogeneic hematopoietic stem cell transplantation.
    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2020, Volume: 26, Issue:2

    Topics: Antiviral Agents; Encephalitis, Viral; Foscarnet; Hematopoietic Stem Cell Transplantation; Herpesvir

2020
Clinical characteristics and outcome of human herpesvirus-6 encephalitis after allogeneic hematopoietic stem cell transplantation.
    Bone marrow transplantation, 2017, Volume: 52, Issue:11

    Topics: Adolescent; Antiviral Agents; Encephalitis, Viral; Foscarnet; Ganciclovir; Herpesvirus 6, Human; Hum

2017
Molecular detection of human herpesvirus 7 DNA in cerebrospinal fluid from adult patients with neurological disorders.
    Journal of neurovirology, 2018, Volume: 24, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA, Viral; Encephalitis, Viral; Femal

2018
Human herpesvirus 6 encephalitis simulating brain metastases in a patient with advanced small-cell lung cancer.
    Chemotherapy, 2013, Volume: 59, Issue:5

    Topics: Antiviral Agents; Brain Neoplasms; Encephalitis, Viral; Foscarnet; Ganciclovir; Herpesvirus 6, Human

2013
A Rare and Fatal Case of Viral Encephalitis in an Immunocompetent Host.
    The American journal of the medical sciences, 2017, Volume: 353, Issue:2

    Topics: Brain; Depression; Diabetes Mellitus, Type 2; Encephalitis, Viral; Fatal Outcome; Female; Foscarnet;

2017
Cytomegalovirus encephalitis/retinitis in allogeneic haematopoietic stem cell transplant recipient treated successfully with combination of cidofovir and foscarnet.
    Pediatric transplantation, 2009, Volume: 13, Issue:7

    Topics: Adolescent; Antiviral Agents; Cidofovir; Cytomegalovirus Infections; Cytosine; Encephalitis, Viral;

2009
Ganciclovir-resistant human herpesvirus-6 encephalitis in a liver transplant patient: a case report.
    Journal of neurovirology, 2011, Volume: 17, Issue:2

    Topics: Aged; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Encephalitis, Viral; Foscarnet; Ganciclo

2011
Prolonged sinus tachycardia caused by human herpesvirus 6 (HHV6) encephalomyelitis after allogeneic bone marrow transplantation.
    Internal medicine (Tokyo, Japan), 2012, Volume: 51, Issue:10

    Topics: Antiviral Agents; Bone Marrow Transplantation; Encephalitis, Viral; Foscarnet; Herpesvirus 6, Human;

2012
Foscarnet against human herpesvirus (HHV)-6 reactivation after allo-SCT: breakthrough HHV-6 encephalitis following antiviral prophylaxis.
    Bone marrow transplantation, 2013, Volume: 48, Issue:2

    Topics: Adolescent; Adult; Aged; Antiviral Agents; Cohort Studies; Encephalitis, Viral; Foscarnet; Hematopoi

2013
Ganciclovir-resistant cytomegalovirus encephalitis in a bone marrow transplant recipient.
    Transplant infectious disease : an official journal of the Transplantation Society, 2002, Volume: 4, Issue:4

    Topics: Adult; Antiviral Agents; Bone Marrow Transplantation; Cytomegalovirus; Cytomegalovirus Infections; D

2002
Cidofovir and foscarnet for treatment of human herpesvirus 6 encephalitis in a neutropenic stem cell transplant recipient.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Jun-15, Volume: 44, Issue:12

    Topics: Antiviral Agents; Cidofovir; Cytosine; Drug Therapy, Combination; Encephalitis, Viral; Foscarnet; Gr

2007
[Salt-wasting nephropathy induced by foscarnet treatment for HHV-6 encephalitis in a hematopoietic stem cell transplant].
    [Rinsho ketsueki] The Japanese journal of clinical hematology, 2008, Volume: 49, Issue:1

    Topics: Antiviral Agents; Encephalitis, Viral; Female; Foscarnet; Hematopoietic Stem Cell Transplantation; H

2008
Cytomegalovirus encephalitis resistant to anti-cytomegalovirus therapy.
    AIDS (London, England), 1995, Volume: 9, Issue:5

    Topics: Bone Marrow Transplantation; Child, Preschool; Cytomegalovirus Infections; Cytomegalovirus Retinitis

1995
Cytomegalovirus ventriculoencephalitis in AIDS patients.
    Scandinavian journal of infectious diseases, 1995, Volume: 27, Issue:2

    Topics: Adult; AIDS-Related Opportunistic Infections; Autopsy; Brain; Cerebral Ventricles; Cerebrospinal Flu

1995
[Clinical value of a polymerase chain reaction on cytomegalovirus DNA in cerebrospinal fluid in HIV patients with neurological symptoms].
    Schweizerische medizinische Wochenschrift, 1995, Apr-29, Volume: 125, Issue:17

    Topics: Adult; AIDS Dementia Complex; Cytomegalovirus; Cytomegalovirus Infections; DNA, Viral; Encephalitis,

1995
Ganciclovir in cytomegalovirus retinitis.
    The Journal of infection, 1995, Volume: 31, Issue:3

    Topics: Adult; Antiviral Agents; Cytomegalovirus Infections; Cytomegalovirus Retinitis; Drug Therapy, Combin

1995
Concurrent ganciclovir and foscarnet treatment for cytomegalovirus encephalitis and retinitis in an infant with acquired immunodeficiency syndrome: case report and review.
    The Pediatric infectious disease journal, 1997, Volume: 16, Issue:8

    Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Infections; Drug Therapy, C

1997
AIDS-related herpes simplex virus encephalitis during maintenance foscarnet therapy.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1998, Volume: 26, Issue:2

    Topics: Adult; AIDS-Related Opportunistic Infections; Animals; Antiviral Agents; Cell Line; Chlorocebus aeth

1998
Successful treatment of human herpesvirus 6 encephalitis in a bone marrow transplant recipient.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 1998, Volume: 27, Issue:3

    Topics: Adolescent; Antiviral Agents; Bone Marrow Transplantation; Encephalitis, Viral; Female; Foscarnet; H

1998
Fatal herpesvirus-6 encephalitis in a recipient of a T-cell-depleted peripheral blood stem cell transplant from a 3-loci mismatched related donor.
    Haematologica, 2000, Volume: 85, Issue:1

    Topics: Cytomegalovirus Infections; DNA, Viral; Encephalitis, Viral; Fatal Outcome; Foscarnet; Ganciclovir;

2000
Successful treatment of human herpesvirus-6 encephalitis after bone marrow transplantation.
    Bone marrow transplantation, 1999, Volume: 24, Issue:11

    Topics: Adult; Bone Marrow Transplantation; Combined Modality Therapy; DNA, Viral; Encephalitis, Viral; Fema

1999
NeuroImages. "Owl's eyes" of CMV ventriculitis.
    Neurology, 2000, Jun-27, Volume: 54, Issue:12

    Topics: Adult; Antiviral Agents; Cerebral Ventricles; Cytomegalovirus; Cytomegalovirus Infections; Encephali

2000
CMV complications in common variable immunodeficiency.
    Immunobiology, 2000, Volume: 202, Issue:2

    Topics: Adult; Antiviral Agents; Azathioprine; B-Lymphocytes; CD4-Positive T-Lymphocytes; CD8-Positive T-Lym

2000
Cytomegalovirus ventriculoencephalitis in a bone marrow transplant recipient receiving antiviral maintenance: clinical and molecular evidence of drug resistance.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2001, Nov-01, Volume: 33, Issue:9

    Topics: Antiviral Agents; Bone Marrow Transplantation; Cerebral Ventricles; Child; Cidofovir; Cytomegaloviru

2001
Herpesvirus-6 encephalitis complicated by Wernicke-Korsakoff syndrome in a pediatric recipient of unrelated cord blood transplantation.
    Journal of pediatric hematology/oncology, 2001, Volume: 23, Issue:9

    Topics: Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Child; Combined Modality Therapy;

2001