foscarnet has been researched along with Disease Exacerbation in 23 studies
Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the efficacy of foscarnet on HIV infection in patients with late-stage HIV disease and multiple drug resistance." | 9.12 | Foscarnet salvage therapy for patients with late-stage HIV disease and multiple drug resistance. ( Bossi, P; Boubezari, I; Calvez, V; Canestri, A; Caumes, E; Dominguez, S; Ghosn, J; Katlama, C; Ktorza, N; Marguet, F; Wirden, M, 2006) |
| "The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir." | 9.08 | Design of clinical trials for drug combinations: cytomegalovirus retinitis--foscarnet and ganciclovir. The CMV retinitis retreatment trial. ( Jabs, DA, 1996) |
| "Acyclovir resistance is rarely seen in herpes simplex virus (HSV) type I encephalitis." | 7.85 | Acyclovir resistance in herpes simplex virus type I encephalitis: a case report. ( Beer, R; Bergmann, M; Helbok, R; Kofler, M; Pfausler, B; Schmutzhard, E, 2017) |
| "Foscarnet-resistant cytomegalovirus (ID50 > 300 microM) was isolated from two patients, one of whom was being treated with foscarnet." | 7.69 | Viral sensitivity testing in patients with cytomegalovirus retinitis clinically resistant to foscarnet or ganciclovir. ( Apuzzo, L; Charache, P; Dunn, JP; Forman, MS; Jabs, DA; MacCumber, MW, 1995) |
| "Foscarnet treatment was initiated in place of acyclovir and his consciousness improved, with a slight improvement in visual acuity." | 6.55 | Acyclovir resistant acute herpes simplex encephalitis associated with acute retinal necrosis: A case report and review of the literature. ( Aoki, M; Fukae, J; Kimura, S; Nabeshima, K; Ogura, H; Tsuboi, Y, 2017) |
| "To evaluate the efficacy of foscarnet on HIV infection in patients with late-stage HIV disease and multiple drug resistance." | 5.12 | Foscarnet salvage therapy for patients with late-stage HIV disease and multiple drug resistance. ( Bossi, P; Boubezari, I; Calvez, V; Canestri, A; Caumes, E; Dominguez, S; Ghosn, J; Katlama, C; Ktorza, N; Marguet, F; Wirden, M, 2006) |
| "The Cytomegalovirus Retinitis Retreatment Trial was a multicenter clinical trial designed to evaluate three treatments for the treatment of relapsed CMV retinitis; (1) foscarnet; (2) 'high-dose' ganciclovir, and (3) combination foscarnet and ganciclovir." | 5.08 | Design of clinical trials for drug combinations: cytomegalovirus retinitis--foscarnet and ganciclovir. The CMV retinitis retreatment trial. ( Jabs, DA, 1996) |
| " Herpes virus type 1 and rarely type 2 may lead to painful and resistant oral ulcers, and systemic treatment with acyclovir, valaciclovir or famciclovir is indicated." | 4.79 | Viral lesions of the mouth in HIV-infected patients. ( Itin, PH; Lautenschlager, S, 1997) |
| "Acyclovir resistance is rarely seen in herpes simplex virus (HSV) type I encephalitis." | 3.85 | Acyclovir resistance in herpes simplex virus type I encephalitis: a case report. ( Beer, R; Bergmann, M; Helbok, R; Kofler, M; Pfausler, B; Schmutzhard, E, 2017) |
| "Foscarnet-resistant cytomegalovirus (ID50 > 300 microM) was isolated from two patients, one of whom was being treated with foscarnet." | 3.69 | Viral sensitivity testing in patients with cytomegalovirus retinitis clinically resistant to foscarnet or ganciclovir. ( Apuzzo, L; Charache, P; Dunn, JP; Forman, MS; Jabs, DA; MacCumber, MW, 1995) |
| " However, patients with positive baseline CMV blood cultures had a significantly more shallow dose-response curve." | 2.68 | Relationship between foscarnet exposure, baseline cytomegalovirus (CMV) blood culture and the time to progression of CMV retinitis in HIV-positive patients. ( Aweeka, F; Drusano, GL; Eaton, C; Gambertoglio, J; Jacobson, M; Lane, HC; Martin-Munley, S; Polis, M, 1996) |
| "Foscarnet treatment was initiated in place of acyclovir and his consciousness improved, with a slight improvement in visual acuity." | 2.55 | Acyclovir resistant acute herpes simplex encephalitis associated with acute retinal necrosis: A case report and review of the literature. ( Aoki, M; Fukae, J; Kimura, S; Nabeshima, K; Ogura, H; Tsuboi, Y, 2017) |
| "The first is the acute retinal necrosis syndrome, which also may be seen in immunocompetent hosts." | 2.41 | Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS. ( Bellehemeur, T; DiazGranados, C; Franco-Paredes, C; Merchant, A; Rimland, D; Sanghi, P, 2002) |
| "The median number of recurrences up to the observation of foveal-sparing retinitis was two (range one to eight), and five patients had active CMV retinitis despite treatment for at least two continuous months." | 2.39 | A foveal-sparing pattern of cytomegalovirus retinitis in the acquired immunodeficiency syndrome. ( Ai, E; Luckie, AP, 1996) |
| "A mild recurrence developed in one eye when ganciclovir and foscarnet were both tapered to a single daily dose." | 1.30 | The progressive outer retinal necrosis syndrome: successful treatment with combination antiviral therapy. ( Ciulla, TA; Duker, JS; Morley, MG; Rutledge, BK, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (60.87) | 18.2507 |
| 2000's | 5 (21.74) | 29.6817 |
| 2010's | 4 (17.39) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ogura, H | 1 |
| Fukae, J | 1 |
| Kimura, S | 1 |
| Aoki, M | 1 |
| Nabeshima, K | 1 |
| Tsuboi, Y | 1 |
| Bergmann, M | 1 |
| Beer, R | 1 |
| Kofler, M | 1 |
| Helbok, R | 1 |
| Pfausler, B | 1 |
| Schmutzhard, E | 1 |
| Chronister, CL | 1 |
| Kaiser, H | 1 |
| Pagani, JM | 1 |
| Weinkove, R | 1 |
| Dickson, M | 1 |
| Eliadou, E | 1 |
| Stace, NH | 1 |
| Goossens, L | 1 |
| Ferguson, P | 1 |
| Nakamoto, BK | 1 |
| Dorotheo, EU | 1 |
| Biousse, V | 1 |
| Tang, RA | 1 |
| Schiffman, JS | 1 |
| Newman, NJ | 1 |
| Canestri, A | 1 |
| Ghosn, J | 1 |
| Wirden, M | 1 |
| Marguet, F | 1 |
| Ktorza, N | 1 |
| Boubezari, I | 1 |
| Dominguez, S | 1 |
| Bossi, P | 1 |
| Caumes, E | 1 |
| Calvez, V | 1 |
| Katlama, C | 1 |
| Fica, A | 1 |
| Cervera, C | 1 |
| Pérez, N | 1 |
| Marcos, MA | 1 |
| Ramírez, J | 1 |
| Linares, L | 1 |
| Soto, G | 1 |
| Navasa, M | 1 |
| Cofan, F | 1 |
| Ricart, MJ | 1 |
| Pérez-Villa, F | 1 |
| Pumarola, T | 1 |
| Moreno, A | 1 |
| Dunn, JP | 1 |
| MacCumber, MW | 1 |
| Forman, MS | 1 |
| Charache, P | 1 |
| Apuzzo, L | 1 |
| Jabs, DA | 4 |
| Holland, GN | 2 |
| Levinson, RD | 1 |
| Jacobson, MA | 2 |
| Luckie, AP | 1 |
| Ai, E | 1 |
| Mocroft, A | 1 |
| Youle, M | 1 |
| Gazzard, B | 1 |
| Morcinek, J | 1 |
| Halai, R | 1 |
| Phillips, AN | 1 |
| Drusano, GL | 1 |
| Aweeka, F | 1 |
| Gambertoglio, J | 1 |
| Jacobson, M | 1 |
| Polis, M | 1 |
| Lane, HC | 1 |
| Eaton, C | 1 |
| Martin-Munley, S | 1 |
| Itin, PH | 1 |
| Lautenschlager, S | 1 |
| Mueller, AJ | 1 |
| Hurwitz, S | 1 |
| Chuang, EL | 1 |
| Friedberg, DN | 1 |
| Haidt, SJ | 1 |
| Heinemann, MH | 1 |
| Kaplan, HJ | 1 |
| Freeman, WR | 1 |
| Pérez-Blázquez, E | 1 |
| Traspas, R | 1 |
| Méndez Marín, I | 1 |
| Montero, M | 1 |
| Ciulla, TA | 1 |
| Rutledge, BK | 1 |
| Morley, MG | 1 |
| Duker, JS | 1 |
| Ries, E | 1 |
| Mühlbauer, B | 1 |
| Ruhswurm, I | 1 |
| Krepler, K | 1 |
| Derbolav, A | 1 |
| Svolba, G | 1 |
| Rieger, A | 1 |
| Wedrich, A | 1 |
| Cochereau, I | 1 |
| Belayachi, N | 1 |
| Diraison, C | 1 |
| Matheron, S | 1 |
| Bouyer, I | 1 |
| Hoang-Xuan, T | 1 |
| Saimot, AG | 1 |
| Coulaud, JP | 1 |
| Holbrook, JT | 1 |
| Davis, MD | 1 |
| Hubbard, LD | 1 |
| Martin, BK | 1 |
| Gilpin, AK | 1 |
| Meinert, C | 1 |
| Reshef, DS | 1 |
| Highleyman, L | 1 |
| Franco-Paredes, C | 1 |
| Bellehemeur, T | 1 |
| Merchant, A | 1 |
| Sanghi, P | 1 |
| DiazGranados, C | 1 |
| Rimland, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Foscarnet-Ganciclovir CMV Retinitis Trial[NCT00000136] | Phase 3 | 234 participants (Actual) | Interventional | 1990-03-31 | Completed | ||
| CMV Retinitis Retreatment Trial[NCT00000766] | Phase 2 | 300 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00000136)
Timeframe: All patients enrolled will be followed until a common study closing date, which was chosen to provide a minimum of 1 year of follow-up for all patients enrolled in the trial.
| Intervention | participants (Number) |
|---|---|
| Foscarnet | 107 |
| Ganciclovir | 127 |
5 reviews available for foscarnet and Disease Exacerbation
| Article | Year |
|---|---|
Acyclovir resistant acute herpes simplex encephalitis associated with acute retinal necrosis: A case report and review of the literature.
Topics: Acute Disease; Acyclovir; Antiviral Agents; Disease Progression; Drug Resistance, Viral; Encephaliti | 2017 |
Progressive outer retinal necrosis presenting with isolated optic neuropathy.
Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Infection | 2004 |
A foveal-sparing pattern of cytomegalovirus retinitis in the acquired immunodeficiency syndrome.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Retinitis; Disease P | 1996 |
Viral lesions of the mouth in HIV-infected patients.
Topics: 2-Aminopurine; Acyclovir; AIDS-Related Opportunistic Infections; Anti-HIV Agents; Cytomegalovirus In | 1997 |
Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS.
Topics: Adrenal Cortex Hormones; Adult; AIDS-Related Opportunistic Infections; Anti-Inflammatory Agents; Ant | 2002 |
7 trials available for foscarnet and Disease Exacerbation
| Article | Year |
|---|---|
Foscarnet salvage therapy for patients with late-stage HIV disease and multiple drug resistance.
Topics: Adult; Aged; CD4 Lymphocyte Count; Disease Progression; Drug Resistance, Multiple, Viral; Foscarnet; | 2006 |
Dose-related difference in progression rates of cytomegalovirus retinopathy during foscarnet maintenance therapy. AIDS Clinical Trials Group Protocol 915 Team.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Cytomegalovirus Re | 1995 |
Assessment of cytomegalovirus retinitis. Clinical evaluation vs centralized grading of fundus photographs. Studies of Ocular Complications of AIDS Research Group, AIDS Clinical Trials Group.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Retinitis; Disease P | 1996 |
Design of clinical trials for drug combinations: cytomegalovirus retinitis--foscarnet and ganciclovir. The CMV retinitis retreatment trial.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Cytomegalovirus Retinitis; Disease Progression | 1996 |
Anti-herpesvirus treatment and risk of Kaposi's sarcoma in HIV infection. Royal Free/Chelsea and Westminster Hospitals Collaborative Group.
Topics: Acyclovir; Adolescent; Adult; Aged; Antiviral Agents; Disease Progression; Female; Follow-Up Studies | 1996 |
Relationship between foscarnet exposure, baseline cytomegalovirus (CMV) blood culture and the time to progression of CMV retinitis in HIV-positive patients.
Topics: Analysis of Variance; Antiviral Agents; Cytomegalovirus Infections; Cytomegalovirus Retinitis; Disea | 1996 |
Risk factors for advancement of cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome. Studies of Ocular Complications of AIDS Research Group.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; CD8-Positive T-Lymphocytes; Cytomegalovirus | 2000 |
11 other studies available for foscarnet and Disease Exacerbation
| Article | Year |
|---|---|
Acyclovir resistance in herpes simplex virus type I encephalitis: a case report.
Topics: Acyclovir; Antiviral Agents; Disease Progression; Drug Resistance, Viral; Drug Substitution; Encepha | 2017 |
Progressive outer retinal necrosis in a patient with acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Diagnosis, Differential; Disease Progression; | 2011 |
Fever and pancytopenia in a patient with Crohn's disease.
Topics: Angiography; Antiviral Agents; Azathioprine; Cecum; Crohn Disease; Digestive System Surgical Procedu | 2013 |
Immunohistochemically proven cytomegalovirus end-organ disease in solid organ transplant patients: clinical features and usefulness of conventional diagnostic tests.
Topics: Adult; Aged; Antiviral Agents; Cytomegalovirus; Cytomegalovirus Infections; Disease Progression; DNA | 2007 |
Viral sensitivity testing in patients with cytomegalovirus retinitis clinically resistant to foscarnet or ganciclovir.
Topics: Adult; AIDS-Related Opportunistic Infections; Cytomegalovirus; Cytomegalovirus Retinitis; Disease Pr | 1995 |
Re-evaluation of time to progression of foscarnet salvage therapy for cytomegalovirus retinitis in AIDS patients clinically resistant to ganciclovir.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Retinitis; Disease Progress | 1997 |
Intravitreal ganciclovir treatment in progressive outer retinal necrosis.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Retinitis; Disease P | 1997 |
The progressive outer retinal necrosis syndrome: successful treatment with combination antiviral therapy.
Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Retinitis | 1998 |
Evaluation of cytomegalovirus retinitis management. Outcome of four years of cytomegalovirus therapy.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Body Fluids; CD4 Lymphocyte Count; Cytomega | 1998 |
[Treatment of CMV retinitis with intravitreal foscarnet].
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Retinitis; Disease Progress | 1998 |
Fomivirsen.
Topics: AIDS-Related Opportunistic Infections; Antiviral Agents; Cidofovir; Clinical Trials as Topic; Cytome | 1998 |