foscarnet has been researched along with Day Blindness in 6 studies
Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eleven clinical centers, a data coordinating center, and a fundus photograph reading center participated in a randomized, controlled, multicenter clinical trial comparing foscarnet and ganciclovir as primary therapy for previously untreated CMV retinitis in 240 patients with AIDS." | 9.08 | Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 5. Clinical features of cytomegalovirus retinitis at diagnosis. Studies of ocular complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group. ( , 1997) |
| "Eleven clinical centers, a data coordinating center, and a fundus photograph reading center participated in a randomized, controlled, multicenter clinical trial comparing foscarnet and ganciclovir as primary therapy for previously untreated CMV retinitis in 240 patients with AIDS." | 5.08 | Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 5. Clinical features of cytomegalovirus retinitis at diagnosis. Studies of ocular complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group. ( , 1997) |
| "Sequential visual field testing is an extremely helpful adjunct to ophthalmoscopy and fundus photography in the management of cytomegalovirus (CMV) retinitis with the antiviral agents ganciclovir or foscarnet in patients with the acquired immune deficiency syndrome (AIDS)." | 3.68 | Visual field testing in the management of cytomegalovirus retinitis. ( Bachman, DM; Bruni, LM; DiGioia, RA; Harris, PJ; McMackin, CM; Pistole, MC; Thomas, RM; Ward, DJ, 1992) |
| "The first is the acute retinal necrosis syndrome, which also may be seen in immunocompetent hosts." | 2.41 | Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS. ( Bellehemeur, T; DiazGranados, C; Franco-Paredes, C; Merchant, A; Rimland, D; Sanghi, P, 2002) |
| "Cytomegalovirus retinitis is probably the result of hematogenous spread of the virus to the retina after systemic reactivation of a latent cytomegalovirus infection." | 2.37 | The diagnosis of cytomegalovirus retinitis. ( Bloom, JN; Palestine, AG, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 3 (50.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ong, SS | 1 |
| Postel, EA | 1 |
| Roarty, JD | 1 |
| Fisher, EJ | 1 |
| Nussbaum, JJ | 1 |
| Franco-Paredes, C | 1 |
| Bellehemeur, T | 1 |
| Merchant, A | 1 |
| Sanghi, P | 1 |
| DiazGranados, C | 1 |
| Rimland, D | 1 |
| Bachman, DM | 1 |
| Bruni, LM | 1 |
| DiGioia, RA | 1 |
| Harris, PJ | 1 |
| McMackin, CM | 1 |
| Pistole, MC | 1 |
| Thomas, RM | 1 |
| Ward, DJ | 1 |
| Bloom, JN | 1 |
| Palestine, AG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Foscarnet-Ganciclovir CMV Retinitis Trial[NCT00000136] | Phase 3 | 234 participants (Actual) | Interventional | 1990-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00000136)
Timeframe: All patients enrolled will be followed until a common study closing date, which was chosen to provide a minimum of 1 year of follow-up for all patients enrolled in the trial.
| Intervention | participants (Number) |
|---|---|
| Foscarnet | 107 |
| Ganciclovir | 127 |
2 reviews available for foscarnet and Day Blindness
| Article | Year |
|---|---|
Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS.
Topics: Adrenal Cortex Hormones; Adult; AIDS-Related Opportunistic Infections; Anti-Inflammatory Agents; Ant | 2002 |
The diagnosis of cytomegalovirus retinitis.
Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Cytomegalovirus Infections; Diagnos | 1988 |
1 trial available for foscarnet and Day Blindness
| Article | Year |
|---|---|
Foscarnet-Ganciclovir Cytomegalovirus Retinitis Trial: 5. Clinical features of cytomegalovirus retinitis at diagnosis. Studies of ocular complications of AIDS Research Group in collaboration with the AIDS Clinical Trials Group.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Antiviral Agents; Cytomegalovirus Infections; | 1997 |
3 other studies available for foscarnet and Day Blindness
| Article | Year |
|---|---|
Sudden Unilateral Decrease in Vision in a Healthy Middle-aged Man.
Topics: Antiviral Agents; Eye Infections, Viral; Fluorescein Angiography; Foscarnet; Herpes Simplex; Herpesv | 2018 |
Long-term visual morbidity of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome.
Topics: Adult; AIDS-Related Opportunistic Infections; Cytomegalovirus Retinitis; Foscarnet; Ganciclovir; Hum | 1993 |
Visual field testing in the management of cytomegalovirus retinitis.
Topics: Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Infections; Eye Infe | 1992 |