Page last updated: 2024-10-27

foscarnet and Acute Retinal Necrosis

foscarnet has been researched along with Acute Retinal Necrosis in 36 studies

Foscarnet: An antiviral agent used in the treatment of cytomegalovirus retinitis. Foscarnet also shows activity against human herpesviruses and HIV.
phosphonoformic acid : Phosphoric acid in which one of the hydroxy groups is replaced by a carboxylic acid group. It is used as the trisodium salt as an antiviral agent in the treatment of cytomegalovirus retinitis (CMV retinitis, an inflamation of the retina that can lead to blindness) and as an alternative to ganciclovir for AIDS patients who require concurrent antiretroviral therapy but are unable to tolerate ganciclovir due to haematological toxicity.

Research Excerpts

ExcerptRelevanceReference
"To report use of intravenous foscarnet or cidofovir for the treatment of refractory acute retinal necrosis (ARN)."7.88Treatment of Refractory Acute Retinal Necrosis with Intravenous Foscarnet or Cidofovir. ( Barshak, MB; Durand, ML; Foster, CS; Kim, IK; Mali, JO; Scott, NL; Stryjewski, TP; Tobin, EH; Young, LH, 2018)
"To report of a case of acute retinal necrosis (ARN), successfully treated with intravitreal foscarnet."7.77Intravitreal foscarnet for the treatment of acyclovir-resistant acute retinal necrosis caused by varicella zoster virus. ( Kim, KS; Lee, MY; Lee, WK, 2011)
"To study the effects of intravitreal foscarnet and the clinical differences between varicella zoster virus (VZV) and herpes simplex virus (HSV) induced acute retinal necrosis (ARN)."7.76Acute retinal necrosis: the effects of intravitreal foscarnet and virus type on outcome. ( Graham, EM; Laidlaw, DA; Pavesio, CE; Stanford, MR; Williamson, TH; Wong, R, 2010)
"Systemic foscarnet can be effective in the management of pediatric acute retinal necrosis caused by HSV-2 when there is an atypical response to conventional acyclovir treatment."7.73Intravenous foscarnet in the management of acyclovir-resistant herpes simplex virus type 2 in acute retinal necrosis in children. ( Charonis, A; Gupta, A; Khurana, RN; Samuel, MA; Tawansy, KA, 2005)
"Foscarnet treatment was initiated in place of acyclovir and his consciousness improved, with a slight improvement in visual acuity."6.55Acyclovir resistant acute herpes simplex encephalitis associated with acute retinal necrosis: A case report and review of the literature. ( Aoki, M; Fukae, J; Kimura, S; Nabeshima, K; Ogura, H; Tsuboi, Y, 2017)
"Acute retinal necrosis secondary to HSV-2 tended to have persistent active retinitis with a higher rate of retinal detachment despite similar treatment protocols, suggesting that in some cases combination intravenous acyclovir and adjuvant intravitreal foscarnet injections are not sufficient."4.02ACUTE RETINAL NECROSIS: Difference in Outcome by Viral Type and Options for Antiviral Therapy. ( Botsford, BW; Eller, AW; Nguyen, VQ, 2021)
"To report use of intravenous foscarnet or cidofovir for the treatment of refractory acute retinal necrosis (ARN)."3.88Treatment of Refractory Acute Retinal Necrosis with Intravenous Foscarnet or Cidofovir. ( Barshak, MB; Durand, ML; Foster, CS; Kim, IK; Mali, JO; Scott, NL; Stryjewski, TP; Tobin, EH; Young, LH, 2018)
"To report of a case of acute retinal necrosis (ARN), successfully treated with intravitreal foscarnet."3.77Intravitreal foscarnet for the treatment of acyclovir-resistant acute retinal necrosis caused by varicella zoster virus. ( Kim, KS; Lee, MY; Lee, WK, 2011)
"To study the effects of intravitreal foscarnet and the clinical differences between varicella zoster virus (VZV) and herpes simplex virus (HSV) induced acute retinal necrosis (ARN)."3.76Acute retinal necrosis: the effects of intravitreal foscarnet and virus type on outcome. ( Graham, EM; Laidlaw, DA; Pavesio, CE; Stanford, MR; Williamson, TH; Wong, R, 2010)
"Systemic foscarnet can be effective in the management of pediatric acute retinal necrosis caused by HSV-2 when there is an atypical response to conventional acyclovir treatment."3.73Intravenous foscarnet in the management of acyclovir-resistant herpes simplex virus type 2 in acute retinal necrosis in children. ( Charonis, A; Gupta, A; Khurana, RN; Samuel, MA; Tawansy, KA, 2005)
"Foscarnet treatment was initiated in place of acyclovir and his consciousness improved, with a slight improvement in visual acuity."2.55Acyclovir resistant acute herpes simplex encephalitis associated with acute retinal necrosis: A case report and review of the literature. ( Aoki, M; Fukae, J; Kimura, S; Nabeshima, K; Ogura, H; Tsuboi, Y, 2017)
"The first is the acute retinal necrosis syndrome, which also may be seen in immunocompetent hosts."2.41Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS. ( Bellehemeur, T; DiazGranados, C; Franco-Paredes, C; Merchant, A; Rimland, D; Sanghi, P, 2002)
" While on maintenance dosing of oral valacyclovir, he experienced reactivation in the form of bilateral vasculitis, which was successfully managed once restarting therapeutic oral dosing."1.51Case Report: Varicella-zoster Encephalitis with Acute Retinal Necrosis and Oculomotor Nerve Palsy. ( Quan, SC; Skondra, D, 2019)
" Chronic suppression with oral antiviral therapy after ARN is recommended to prevent involvement of the contralateral eye, though there is no consensus on the duration and dosage of antivirals."1.51Acute retinal necrosis in a patient with remote severe herpes simplex encephalitis. ( Kobayashi, T; Meier, J; Sekar, P; Streit, J, 2019)
"Retinal detachment is the main complication."1.32[Acute retinal necrosis: clinical presentation, treatment, and prognosis in a series of 22 patients]. ( Laroche, L; Larricart, P; Metge, F; Monin, C; Morel, C; Roman, S; Scheer, S, 2004)
"A 43-year-old man with small lymphocytic lymphoma was diagnosed with progressive outer retinal necrosis in his left eye."1.31Progressive outer retinal necrosis syndrome in a lymphoma patient with good visual outcome. ( Foster, RE; Neuss, MN; Osher, RH; Petersen, MR, 2001)
"A mild recurrence developed in one eye when ganciclovir and foscarnet were both tapered to a single daily dose."1.30The progressive outer retinal necrosis syndrome: successful treatment with combination antiviral therapy. ( Ciulla, TA; Duker, JS; Morley, MG; Rutledge, BK, 1998)
"Retinal detachment was seen in 14 patients (relative frequency, 19."1.29Retinal detachment in patients with acquired immunodeficiency syndrome. ( Bogner, JR; Geier, SA; Goebel, FD; Klauss, V; Sadri, I; Schmidt-Kittler, H, 1994)

Research

Studies (36)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (19.44)18.2507
2000's11 (30.56)29.6817
2010's15 (41.67)24.3611
2020's3 (8.33)2.80

Authors

AuthorsStudies
Hafidi, M1
Janin-Manificat, H1
Denis, P1
Charleux, B1
Rabilloud, M1
Boibieux, A1
Burillon, C1
Kodjikian, L1
Frobert, E1
Pockar, S1
Jones, NP1
Chhabra, R1
Steeples, LR1
Spaide, RF2
Byun, SS1
Botsford, BW1
Nguyen, VQ1
Eller, AW1
Ogura, H1
Fukae, J1
Kimura, S1
Aoki, M1
Nabeshima, K1
Tsuboi, Y1
Ong, SS1
Postel, EA1
Quan, SC1
Skondra, D1
Kobayashi, T1
Sekar, P1
Meier, J1
Streit, J1
Or, C1
Press, N1
Forooghian, F1
Dokey, AT1
Haug, SJ1
McDonald, HR1
Cunningham, ET1
Lujan, BJ1
Fu, AD1
Jumper, JM1
Weissman, HM1
Biousse, V1
Schechter, MC1
Del Rio, C1
Yeh, S2
Le, TD1
Weisbrod, D1
Mandelcorn, ED1
Stryjewski, TP1
Scott, NL1
Barshak, MB1
Tobin, EH1
Mali, JO1
Young, LH1
Foster, CS1
Kim, IK1
Durand, ML1
Schoenberger, SD1
Kim, SJ2
Thorne, JE1
Mruthyunjaya, P1
Bakri, SJ1
Ehlers, JP1
Lo, WR1
Wong, R1
Pavesio, CE1
Laidlaw, DA1
Williamson, TH1
Graham, EM1
Stanford, MR1
Meghpara, B1
Sulkowski, G1
Kesen, MR1
Tessler, HH1
Goldstein, DA1
Chronister, CL1
Kaiser, H1
Pagani, JM1
Lee, MY1
Kim, KS1
Lee, WK1
Scott, IU2
Luu, KM1
Davis, JL3
Gain, P1
Chiquet, C1
Thuret, G1
Drouet, E1
Antoine, JC1
Benz, MS1
Glaser, JS1
Morel, C1
Metge, F1
Roman, S1
Scheer, S1
Larricart, P1
Monin, C1
Laroche, L1
Tran, TH1
Stanescu, D1
Caspers-Velu, L1
Rozenberg, F1
Liesnard, C1
Gaudric, A1
Lehoang, P1
Bodaghi, B1
Khurana, RN1
Charonis, A1
Samuel, MA1
Gupta, A1
Tawansy, KA1
Almony, A1
Dhalla, MS1
Feiner, L1
Shah, GK1
Geier, SA1
Klauss, V1
Bogner, JR1
Schmidt-Kittler, H1
Sadri, I1
Goebel, FD1
Smit, WM1
Wagemans, MA1
Jansen, CL1
vd Horn, GJ1
Surachno, JS1
Caumes, E1
Gatineau, M1
Bricaire, F1
Dohin, E1
Katlama, C1
Gentilini, M1
Klein, JL1
Sandy, C1
Migdal, CS1
Main, J1
Martin, DF1
Teich, SA1
Katz, A1
Toth, I1
Pérez-Blázquez, E1
Traspas, R1
Méndez Marín, I1
Montero, M1
Ciulla, TA1
Rutledge, BK1
Morley, MG1
Duker, JS1
Foster, RE1
Petersen, MR1
Neuss, MN1
Osher, RH1
Franco-Paredes, C1
Bellehemeur, T1
Merchant, A1
Sanghi, P1
DiazGranados, C1
Rimland, D1
Verm, AM1

Reviews

5 reviews available for foscarnet and Acute Retinal Necrosis

ArticleYear
Acyclovir resistant acute herpes simplex encephalitis associated with acute retinal necrosis: A case report and review of the literature.
    Rinsho shinkeigaku = Clinical neurology, 2017, 05-27, Volume: 57, Issue:5

    Topics: Acute Disease; Acyclovir; Antiviral Agents; Disease Progression; Drug Resistance, Viral; Encephaliti

2017
Bilateral central retinal artery occlusion associated with herpes simplex virus-associated acute retinal necrosis and meningitis: case report and literature review.
    Ophthalmic surgery, lasers & imaging retina, 2015, Volume: 46, Issue:2

    Topics: Antibodies, Viral; Antiviral Agents; Aqueous Humor; DNA, Viral; Drug Therapy, Combination; Eye Infec

2015
Diagnosis and Treatment of Acute Retinal Necrosis: A Report by the American Academy of Ophthalmology.
    Ophthalmology, 2017, Volume: 124, Issue:3

    Topics: Academies and Institutes; Acyclovir; Antiviral Agents; Aqueous Humor; Biomedical Technology; DNA, Vi

2017
Clinical characteristics of acute HSV-2 retinal necrosis.
    American journal of ophthalmology, 2004, Volume: 137, Issue:5

    Topics: Acyclovir; Adult; Antiviral Agents; Aqueous Humor; Child; DNA, Viral; Drug Therapy, Combination; Eye

2004
Aseptic meningitis and optic neuritis preceding varicella-zoster progressive outer retinal necrosis in a patient with AIDS.
    AIDS (London, England), 2002, May-03, Volume: 16, Issue:7

    Topics: Adrenal Cortex Hormones; Adult; AIDS-Related Opportunistic Infections; Anti-Inflammatory Agents; Ant

2002

Other Studies

31 other studies available for foscarnet and Acute Retinal Necrosis

ArticleYear
Acute Retinal Necrosis: Virological Features Using Quantitative Polymerase Chain Reaction, Therapeutic Management, and Clinical Outcomes.
    American journal of ophthalmology, 2019, Volume: 208

    Topics: Adult; Aged; Aged, 80 and over; Antiviral Agents; Aqueous Humor; Cytomegalovirus Retinitis; DNA, Vir

2019
Detection of Pre-clinical Involvement of the Second Eye in Viral Acute Retinal Necrosis Using Optical Coherence Tomography.
    Ocular immunology and inflammation, 2022, Jan-02, Volume: 30, Issue:1

    Topics: Eye Infections, Viral; Foscarnet; Herpesvirus 3, Human; Humans; Male; Middle Aged; Retinal Necrosis

2022
RECURRENT ACUTE RETINAL NECROSIS.
    Retinal cases & brief reports, 2022, 11-01, Volume: 16, Issue:6

    Topics: Acyclovir; Antiviral Agents; Child, Preschool; Female; Foscarnet; Humans; Retinal Detachment; Retina

2022
ACUTE RETINAL NECROSIS: Difference in Outcome by Viral Type and Options for Antiviral Therapy.
    Retina (Philadelphia, Pa.), 2021, Jul-01, Volume: 41, Issue:7

    Topics: Acyclovir; Adult; Aged; Aged, 80 and over; Antiviral Agents; DNA, Viral; Eye Infections, Viral; Fema

2021
Sudden Unilateral Decrease in Vision in a Healthy Middle-aged Man.
    JAMA ophthalmology, 2018, 11-01, Volume: 136, Issue:11

    Topics: Antiviral Agents; Eye Infections, Viral; Fluorescein Angiography; Foscarnet; Herpes Simplex; Herpesv

2018
Case Report: Varicella-zoster Encephalitis with Acute Retinal Necrosis and Oculomotor Nerve Palsy.
    Optometry and vision science : official publication of the American Academy of Optometry, 2019, Volume: 96, Issue:5

    Topics: Aged; Antiviral Agents; Aqueous Humor; Cerebrospinal Fluid; Drug Therapy, Combination; Encephalitis,

2019
Acute retinal necrosis in a patient with remote severe herpes simplex encephalitis.
    BMJ case reports, 2019, May-27, Volume: 12, Issue:5

    Topics: Acute Disease; Acyclovir; Antiviral Agents; Diagnosis, Differential; Encephalitis, Herpes Simplex; E

2019
Acute retinal necrosis secondary to cytomegalovirus following successful treatment of cytomegalovirus anterior uveitis in an immunocompetent adult.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2013, Volume: 48, Issue:2

    Topics: Antiviral Agents; Aqueous Humor; Cytomegalovirus; Cytomegalovirus Infections; DNA, Viral; Drug Thera

2013
Acute retinal necrosis secondary to multidrug-resistant herpes simplex virus 2 in an immunocompetent adolescent.
    Retinal cases & brief reports, 2014,Fall, Volume: 8, Issue:4

    Topics: Adolescent; Antiviral Agents; Drug Resistance, Viral; Eye Infections, Viral; Foscarnet; Herpes Simpl

2014
Chorioretinitis with exudative retinal detachment secondary to varicella zoster virus.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2015, Volume: 50, Issue:5

    Topics: Acyclovir; Administration, Oral; Antiviral Agents; Chorioretinitis; Drug Combinations; Exudates and

2015
Treatment of Refractory Acute Retinal Necrosis with Intravenous Foscarnet or Cidofovir.
    Ocular immunology and inflammation, 2018, Volume: 26, Issue:2

    Topics: Aged; Aged, 80 and over; Antiviral Agents; Cidofovir; Cytosine; Eye Infections, Viral; Foscarnet; He

2018
Acute retinal necrosis.
    Ophthalmology, 2008, Volume: 115, Issue:6

    Topics: Acyclovir; Antiviral Agents; DNA, Viral; Drug Therapy, Combination; Eye Infections, Viral; Foscarnet

2008
Acute retinal necrosis: the effects of intravitreal foscarnet and virus type on outcome.
    Ophthalmology, 2010, Volume: 117, Issue:3

    Topics: Acyclovir; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Child; Eye Infections, Vira

2010
Long-term follow-up of acute retinal necrosis.
    Retina (Philadelphia, Pa.), 2010, Volume: 30, Issue:5

    Topics: Adolescent; Adult; Aged; Antiviral Agents; Child; Cytomegalovirus; Cytomegalovirus Infections; Drug

2010
Progressive outer retinal necrosis in a patient with acquired immune deficiency syndrome.
    Clinical & experimental optometry, 2011, Volume: 94, Issue:4

    Topics: Acquired Immunodeficiency Syndrome; Antiviral Agents; Diagnosis, Differential; Disease Progression;

2011
Intravitreal foscarnet for the treatment of acyclovir-resistant acute retinal necrosis caused by varicella zoster virus.
    Ocular immunology and inflammation, 2011, Volume: 19, Issue:3

    Topics: Acyclovir; Adult; Antiviral Agents; Drug Resistance, Viral; Foscarnet; Herpes Zoster; Herpesvirus 3,

2011
Intravitreal antivirals in the management of patients with acquired immunodeficiency syndrome with progressive outer retinal necrosis.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2002, Volume: 120, Issue:9

    Topics: Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Drug Therapy, Combination; Female; F

2002
Herpes simplex virus type 1 encephalitis associated with acute retinal necrosis syndrome in an immunocompetent patient.
    Acta ophthalmologica Scandinavica, 2002, Volume: 80, Issue:5

    Topics: Adult; Antiviral Agents; Aqueous Humor; Cerebrospinal Fluid; DNA, Viral; Encephalitis, Herpes Simple

2002
Progressive outer retinal necrosis in immunocompetent patients treated initially for optic neuropathy with systemic corticosteroids.
    American journal of ophthalmology, 2003, Volume: 135, Issue:4

    Topics: Acyclovir; Aged; Antiviral Agents; Aqueous Humor; Blindness; DNA, Viral; Drug Therapy, Combination;

2003
[Acute retinal necrosis: clinical presentation, treatment, and prognosis in a series of 22 patients].
    Journal francais d'ophtalmologie, 2004, Volume: 27, Issue:1

    Topics: Acyclovir; Adolescent; Adult; Aged; Antiviral Agents; Cytomegalovirus Retinitis; Drug Therapy, Combi

2004
Intravenous foscarnet in the management of acyclovir-resistant herpes simplex virus type 2 in acute retinal necrosis in children.
    Medical science monitor : international medical journal of experimental and clinical research, 2005, Volume: 11, Issue:12

    Topics: Acyclovir; Adolescent; Antiviral Agents; Child; Drug Resistance, Viral; Female; Foscarnet; Herpes Si

2005
Macular optical coherence tomography findings in progressive outer retinal necrosis.
    Canadian journal of ophthalmology. Journal canadien d'ophtalmologie, 2007, Volume: 42, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Antiviral Agents; Aqueous Humor; DNA, Viral; Drug The

2007
Retinal detachment in patients with acquired immunodeficiency syndrome.
    German journal of ophthalmology, 1994, Volume: 3, Issue:1

    Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Cytomegalovirus Retinitis; Follow-Up Studie

1994
Acute retinal necrosis in a renal allograft recipient--an unusual manifestation of cytomegalovirus infection.
    Transplantation, 1993, Volume: 55, Issue:1

    Topics: Adult; Cytomegalovirus Infections; Foscarnet; Ganciclovir; Humans; Kidney Transplantation; Male; Ret

1993
Foscarnet-induced vulvar erosion.
    Journal of the American Academy of Dermatology, 1993, Volume: 28, Issue:5 Pt 1

    Topics: Adult; Female; Foscarnet; HIV Infections; Humans; Retinal Necrosis Syndrome, Acute; Ulcer; Vulvar Di

1993
Famciclovir in AIDS-related acute retinal necrosis.
    AIDS (London, England), 1996, Volume: 10, Issue:11

    Topics: 2-Aminopurine; Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Famciclovir; Foscarnet;

1996
Successful treatment of progressive outer retinal necrosis syndrome.
    Retina (Philadelphia, Pa.), 1996, Volume: 16, Issue:6

    Topics: Acquired Immunodeficiency Syndrome; Acyclovir; Adult; Antiviral Agents; Female; Foscarnet; Fundus Oc

1996
Intravitreal ganciclovir treatment in progressive outer retinal necrosis.
    American journal of ophthalmology, 1997, Volume: 124, Issue:3

    Topics: Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Retinitis; Disease P

1997
The progressive outer retinal necrosis syndrome: successful treatment with combination antiviral therapy.
    Ophthalmic surgery and lasers, 1998, Volume: 29, Issue:3

    Topics: Acyclovir; Adult; AIDS-Related Opportunistic Infections; Antiviral Agents; Cytomegalovirus Retinitis

1998
Progressive outer retinal necrosis syndrome in a lymphoma patient with good visual outcome.
    American journal of ophthalmology, 2001, Volume: 132, Issue:1

    Topics: Adult; Antiviral Agents; Drug Therapy, Combination; Foscarnet; Ganciclovir; Herpes Zoster Ophthalmic

2001
Necrotizing herpetic retinopathy associated with Ramsay Hunt syndrome.
    Archives of ophthalmology (Chicago, Ill. : 1960), 2002, Volume: 120, Issue:7

    Topics: Acquired Immunodeficiency Syndrome; Adult; Antiviral Agents; Drug Therapy, Combination; Female; Fosc

2002