fosbretabulin has been researched along with Triple-Negative-Breast-Neoplasms* in 2 studies
2 other study(ies) available for fosbretabulin and Triple-Negative-Breast-Neoplasms
| Article | Year |
|---|---|
Pegylated liposomal encapsulation improves the antitumor efficacy of combretastatin A4 in murine 4T1 triple-negative breast cancer model.
Topics: Animals; Humans; Liposomes; Mice; Polyethylene Glycols; Stilbenes; Triple Negative Breast Neoplasms | 2022 |
Development of a novel near-infrared fluorescent theranostic combretastain A-4 analogue, YK-5-252, to target triple negative breast cancer.
The treatment of triple negative breast cancer (TNBC) is a significant challenge to cancer research. The lack of hormone receptors limits the treatment options available to patients with this diagnosis, forcing them to endure prolonged radiation and chemotherapy. Anti-angiogenesis is a chemotherapeutic strategy that targets the vasculature of tumors. Combretastatin A-4 (CA-4) is a well-known vasculature-disrupting agent, which has been shown to effectively kill a variety of cancers through inhibition of tubulin polymerization. Due to its toxicity, small molecule analogues of CA-4 have been sought out. We have designed a novel dual action CA-4 prodrug, YK-5-252, which releases the drug through a disulfide bond cleavage mechanism and contains a near-infrared (NIR) fluorophore, which allows fluorescence monitoring of cleavage. This disulfide linkage causes CA-4 to become effective only when released by glutathione (GSH) reducing the toxicity of the drug while simultaneously releasing the NIR fluorophore. Therefore the prodrug, YK-5-252, represents a novel CA-4 analogue which has reduced toxicity and can be used for theranostics imaging. Topics: Benzopyrans; Cell Line, Tumor; Cell Proliferation; Flow Cytometry; Humans; Mass Spectrometry; Proton Magnetic Resonance Spectroscopy; Stilbenes; Theranostic Nanomedicine; Triple Negative Breast Neoplasms; Tubulin Modulators | 2017 |