forsythoside-b and Liver-Cirrhosis

Transient receptor potential vanilloid 3 (TRPV3) is a member of the TRP superfamily. Previous studies have demonstrated that TRPV3 is associated with myocardial fibrosis. However, the role of TRPV3 in hepatic fibrosis and its underlying mechanisms are still unclear. This study aimed to elucidate the underlying effects of TRPV3 on hepatic fibrosis at multiple biological levels. First, immunohistochemical staining was performed to examine TRPV3 expression in human hepatic cirrhosis tissues. Then, we established a CCl

Topics: Animals; Caffeic Acids; Carbon Tetrachloride; Cells, Cultured; Disease Models, Animal; Gene Knockdown Techniques; Glucosides; Hepatic Stellate Cells; Humans; Immunohistochemistry; Liver Cirrhosis; Liver Cirrhosis, Experimental; Male; Mice; Mice, Inbred C57BL; Phenylacetates; RNA, Messenger; RNA, Small Interfering; TRPV Cation Channels; Up-Regulation