forssman-glycolipid and Graves-Disease

forssman-glycolipid has been researched along with Graves-Disease* in 1 studies

Other Studies

1 other study(ies) available for forssman-glycolipid and Graves-Disease

ArticleYear
Autoantibodies against Forssman glycolipids in Graves' disease and Hashimoto's thyroiditis.
    Clinical and experimental immunology, 1991, Volume: 86, Issue:3

    Sera from patients with Graves' disease and Hashimoto's thyroiditis have been shown to react with the Forssman glycolipid antigen (Gb5) using the techniques of high performance thin-layer chromatography (HPTLC) immunostaining and ELISA. Human monoclonal antibodies (MoAbs) have been prepared by fusion of human myeloma with peripheral lymphocytes from patients with Graves' disease. A MoAb, TRMo-4, reacted strongly and specifically with Gb5. These results suggest that anti-Forssman antibody may be involved in the pathogenesis of these autoimmune diseases. The detection of anti-Forssman glycolipid antibody may provide a useful means for clinical diagnosis and therapy.

    Topics: Antibodies, Monoclonal; Antigen-Antibody Reactions; Autoantibodies; Ceramides; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Forssman Antigen; Gangliosides; Globosides; Graves Disease; Humans; Immunoglobulin G; Receptors, Thyrotropin; Recombinant Fusion Proteins; Thyroiditis, Autoimmune

1991