forodesine has been researched along with Malaria* in 2 studies
2 review(s) available for forodesine and Malaria
Article | Year |
---|---|
Plasmodium Purine Metabolism and Its Inhibition by Nucleoside and Nucleotide Analogues.
Malaria still affects around 200 million people and is responsible for more than 400,000 deaths per year, mostly children in subequatorial areas. This disease is caused by parasites of the Topics: Antimalarials; Biological Transport; Drug Design; Erythrocytes; Humans; Inhibitory Concentration 50; Malaria; Nucleosides; Nucleotides; Plasmodium falciparum; Purines; Pyrimidines | 2019 |
Immucillins as antibiotics for T-cell proliferation and malaria.
The genetic deficiency of human PNP causes a specific immunodeficiency by inducing apoptosis in dividing T-cells. Powerful inhibitors of PNP have been designed from the experimental determination of the transition state structure of PNPs. The Immucillins are transition state analogue inhibitors with Kd values as low as 7 pM. In the presence of deoxyguanosine the Immucillins kill activated human T-cells but not other cell types. The Immucillins are orally available and of low toxicity to mice. Immucillins also inhibit PNP from Plasmodium falciparum. Parasites cultured in human erythrocytes are killed by purine starvation in the presence of Immucillins and can be rescued by hypoxanthine. Topics: Animals; Anti-Bacterial Agents; Cell Proliferation; Deoxyguanosine; Erythrocytes; Humans; Hypoxanthine; Kinetics; Lymphocyte Activation; Malaria; Models, Chemical; Phenotype; Plasmodium falciparum; Purine Nucleosides; Purines; Pyrimidinones; Pyrroles; T-Lymphocytes | 2004 |