formycin and Cell-Transformation--Neoplastic

formycin has been researched along with Cell-Transformation--Neoplastic* in 1 studies

Other Studies

1 other study(ies) available for formycin and Cell-Transformation--Neoplastic

ArticleYear
Induction of erythroid differentiation in leukaemic K562 cells by an S-adenosylhomocysteine hydrolase inhibitor, aristeromycin.
    Biochemical and biophysical research communications, 1995, Feb-06, Volume: 207, Issue:1

    We have isolated an unusual nucleoside, aristeromycin, from the culture filtrate of Actinomycetes as a compound that induces normal morphology in v-ablts-NIH3T3 cells. Aristeromycin also induced erythroid differentiation in abl-expressing human chronic myelogenous leukaemia K562 cells. It did not affect the amount of Abl or the Abl-associated tyrosine kinase activity in either v-ablts-NIH3T3 or K562 cells. As a potent inhibitor of S-adenosylhomocysteine hydrolase, aristeromycin inhibited methylation of phosphatidylethanolamine to form phosphatidylcholine in K562 cells. Among aristeromycin analogues, the activity to inhibit S-adenosylhomocysteine hydrolase was paralleled with the induction of erythroid differentiation. Thus, aristeromycin inhibits abl functions indirectly, possibly by inhibiting biological methylations.

    Topics: 3T3 Cells; Adenosine; Adenosylhomocysteinase; Animals; Cell Differentiation; Cell Division; Cell Line; Cell Line, Transformed; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Formycins; Genes, abl; Humans; Hydrolases; Isomerism; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Tubercidin; Tumor Cells, Cultured

1995