Page last updated: 2024-10-16

formic acid and Pregnancy

formic acid has been researched along with Pregnancy in 23 studies

formic acid: RN given refers to parent cpd
formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.

Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.

Research Excerpts

ExcerptRelevanceReference
"Sulfasalazine has been identified as a candidate molecule to be investigated as an intervention to treat preterm pre-eclampsia during pregnancy."4.31An LC-MS/MS method for the simultaneous quantitation of sulfasalazine and sulfapyridine in human placenta. ( Brownfoot, F; Cluver, C; Decloedt, E; Kellermann, T; Louw, V, 2023)
" Methanol is teratogenic in rodents and, although the exact toxic species is not known, teratogenesis may result from the enzymatic biotransformation of H3COH to formaldehyde (CH2O) and formic acid causing increased biological reactivity and toxicity."1.32Glutathione depletion modulates methanol, formaldehyde and formate toxicity in cultured rat conceptuses. ( Dixon, M; Hansen, JM; Harris, C, 2004)
" MeOH has been shown to be developmentally toxic in mice and rats both in vivo and in vitro, but rodents neither accumulate formate nor develop acidosis after MeOH exposure."1.29Developmental toxicity of formate and formic acid in whole embryo culture: a comparative study with mouse and rat embryos. ( Andrews, JE; Ebron-McCoy, M; Kavlock, RJ; Rogers, JM, 1995)
"Mouse embryos develop exencephaly when dams are exposed by inhalation to high concentrations (> or = 10,000 ppm) of methanol on gestational day 8 (GD8; copulation plug = GD0)."1.29Role of formate in methanol-induced exencephaly in CD-1 mice. ( Bolon, B; Dorman, DC; Elswick, B; LaPerle, KM; Struve, MF; Welsch, F; Wong, BA, 1995)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19902 (8.70)18.7374
1990's5 (21.74)18.2507
2000's3 (13.04)29.6817
2010's8 (34.78)24.3611
2020's5 (21.74)2.80

Authors

AuthorsStudies
Smith, BI1
Cady, SV1
Aceto, HW1
Louw, V1
Brownfoot, F1
Cluver, C1
Decloedt, E1
Kellermann, T1
Strickland, AL1
Blacketer, S1
Molberg, K1
Markantonis, J1
Lucas, E1
Brosnan, JT5
Brosnan, ME5
Tingley, G1
MacMillan, L2
Harnett, B2
Pongnopparat, T3
Marshall, JD1
Luthra, G1
Vuckovic, I1
Bangdiwala, A1
Gray, H1
Redmon, JB1
Barrett, ES1
Sathyanarayana, S1
Nguyen, RHN1
Swan, SH1
Zhang, S1
Dzeja, P1
Macura, SI1
Nair, KS1
Camperi, J1
Pichon, V1
Fournier, T1
Delaunay, N1
Plumptre, L1
Masih, SP1
Visentin, CE1
Berger, H1
Lamers, Y1
Caudill, MA2
Malysheva, OV1
O'Connor, DL1
Kim, YI1
Washburn, SE1
Malysheva, O1
MacFarlane, AJ1
Behan, NA1
Vanderhaeghen, S1
Lacroix, C1
Schwab, C1
Ema, M1
Naya, M1
Yoshida, K1
Nagaosa, R1
Wang, X1
Vernikovskaya, DI1
Abdelrahman, DR1
Hankins, GD1
Ahmed, MS1
Nanovskaya, TN1
Patel, H1
Pietro, ED1
MacKenzie, RE1
Harris, C2
Dixon, M1
Hansen, JM2
Contreras, KM1
Shambaugh, GE1
Angulo, MC1
Koehler, RR1
Andrews, JE2
Ebron-McCoy, M2
Kavlock, RJ1
Rogers, JM1
Schmid, K1
Schaller, KH1
Angerer, J1
Lehnert, G1
Dorman, DC1
Bolon, B1
Struve, MF1
LaPerle, KM1
Wong, BA1
Elswick, B1
Welsch, F1
Brown-Woodman, PD1
Huq, F1
Hayes, L1
Herlihy, C1
Picker, K1
Webster, WS1
Schmid, JE1
Svendsgaard, D1
Brennecke, SP1
Chen, S1
King, RG1
Boura, AL1

Reviews

3 reviews available for formic acid and Pregnancy

ArticleYear
Formate and its role in amino acid metabolism.
    Current opinion in clinical nutrition and metabolic care, 2020, Volume: 23, Issue:1

    Topics: Amino Acid Oxidoreductases; Amino Acids; Animals; Female; Formates; Humans; Mice; Multienzyme Comple

2020
Formate: The Neglected Member of One-Carbon Metabolism.
    Annual review of nutrition, 2016, 07-17, Volume: 36

    Topics: Animals; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Female; Fetal Development; Forma

2016
Reproductive and developmental toxicity of degradation products of refrigerants in experimental animals.
    Reproductive toxicology (Elmsford, N.Y.), 2010, Volume: 29, Issue:1

    Topics: Abnormalities, Drug-Induced; Aldehydes; Animals; Carbon Compounds, Inorganic; Carbon Dioxide; Carbon

2010

Trials

1 trial available for formic acid and Pregnancy

ArticleYear
Effect of formic acid treatment on colostrum quality, and on absorption and function of immunoglobulins: a randomized controlled trial in Holstein dairy calves.
    BMC veterinary research, 2022, Aug-17, Volume: 18, Issue:1

    Topics: Animals; Animals, Newborn; Cattle; Colostrum; Female; Formates; Immunoglobulin G; Pregnancy

2022

Other Studies

19 other studies available for formic acid and Pregnancy

ArticleYear
An LC-MS/MS method for the simultaneous quantitation of sulfasalazine and sulfapyridine in human placenta.
    Journal of pharmaceutical and biomedical analysis, 2023, Oct-25, Volume: 235

    Topics: Chromatography, Liquid; Female; Humans; Infant, Newborn; Methanol; Placenta; Pre-Eclampsia; Pregnanc

2023
Effects of Decalcifying Agents of Variable Duration on PD-L1 Immunohistochemistry.
    American journal of clinical pathology, 2020, 01-02, Volume: 153, Issue:2

    Topics: B7-H1 Antigen; Calcium Chelating Agents; Edetic Acid; Female; Formates; Humans; Hydrochloric Acid; I

2020
Plasma Formate Is Greater in Fetal and Neonatal Rats Compared with Their Mothers.
    The Journal of nutrition, 2020, 05-01, Volume: 150, Issue:5

    Topics: Aging; Animals; Animals, Newborn; Female; Fetus; Formates; Liver; Maternal-Fetal Exchange; Mothers;

2020
First and second trimester urinary metabolic profiles and fetal growth restriction: an exploratory nested case-control study within the infant development and environment study.
    BMC pregnancy and childbirth, 2018, 02-08, Volume: 18, Issue:1

    Topics: Acetates; Adult; Case-Control Studies; Female; Fetal Growth Retardation; Formates; Gestational Age;

2018
First profiling in hydrophilic interaction liquid chromatography of intact human chorionic gonadotropin isoforms.
    Journal of pharmaceutical and biomedical analysis, 2019, Sep-10, Volume: 174

    Topics: Chorionic Gonadotropin; Chromatography, Liquid; Female; Formates; Glycoproteins; Glycosylation; Huma

2019
Formate concentrations in maternal plasma during pregnancy and in cord blood in a cohort of pregnant Canadian women: relations to genetic polymorphisms and plasma metabolites.
    The American journal of clinical nutrition, 2019, 11-01, Volume: 110, Issue:5

    Topics: Adult; Amino Acids; Cohort Studies; Female; Fetal Blood; Formates; Genotype; Humans; Methylenetetrah

2019
Formate metabolism in fetal and neonatal sheep.
    American journal of physiology. Endocrinology and metabolism, 2015, May-15, Volume: 308, Issue:10

    Topics: Amniotic Fluid; Animals; Animals, Newborn; Female; Fetus; Folic Acid; Formates; Homocysteine; Postpa

2015
Methanogen communities in stools of humans of different age and health status and co-occurrence with bacteria.
    FEMS microbiology letters, 2015, Volume: 362, Issue:13

    Topics: Adolescent; Adult; Age Factors; Aged; Bacteria; Carbohydrate Metabolism; Child; Euryarchaeota; Feces

2015
Simultaneous quantitative determination of bupropion and its three major metabolites in human umbilical cord plasma and placental tissue using high-performance liquid chromatography-tandem mass spectrometry.
    Journal of pharmaceutical and biomedical analysis, 2012, Volume: 70

    Topics: Acetonitriles; Biotransformation; Buffers; Bupropion; Calibration; Chemical Precipitation; Chromatog

2012
Mammalian fibroblasts lacking mitochondrial NAD+-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase are glycine auxotrophs.
    The Journal of biological chemistry, 2003, May-23, Volume: 278, Issue:21

    Topics: Aminohydrolases; Animals; Blotting, Northern; Blotting, Southern; Carbon Radioisotopes; Cell Divisio

2003
Glutathione depletion modulates methanol, formaldehyde and formate toxicity in cultured rat conceptuses.
    Cell biology and toxicology, 2004, Volume: 20, Issue:3

    Topics: Animals; Buthionine Sulfoximine; Cysteine; Embryo, Mammalian; Female; Formaldehyde; Formates; Glutat

2004
Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity.
    Birth defects research. Part A, Clinical and molecular teratology, 2005, Volume: 73, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Embryo Loss; Female; Formaldehyde; Formates; Maternal Exp

2005
Fetal fuels. VII. Ketone bodies inhibit synthesis of purines in fetal rat brain.
    The American journal of physiology, 1984, Volume: 247, Issue:1 Pt 1

    Topics: 3-Hydroxybutyric Acid; Acetoacetates; Adenine; Animals; Brain; Carbon Radioisotopes; Cycloheximide;

1984
Developmental toxicity of formate and formic acid in whole embryo culture: a comparative study with mouse and rat embryos.
    Teratology, 1995, Volume: 51, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Culture Techniques; DNA; Dose-Response Relationship, Drug; Emb

1995
[The importance of formic acid excretion in the urine for environmental and occupational medicine questions].
    Zentralblatt fur Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine, 1994, Volume: 196, Issue:2

    Topics: Administration, Inhalation; Adult; Air Pollution; Child; Circadian Rhythm; Creatinine; Environmental

1994
Role of formate in methanol-induced exencephaly in CD-1 mice.
    Teratology, 1995, Volume: 52, Issue:1

    Topics: Animals; Decidua; Embryonic and Fetal Development; Erythrocyte Count; Female; Fomepizole; Formates;

1995
In vitro assessment of the effect of methanol and the metabolite, formic acid, on embryonic development of the rat.
    Teratology, 1995, Volume: 52, Issue:4

    Topics: Animals; Drug Combinations; Embryonic and Fetal Development; Female; Formates; Humans; Hydrogen-Ion

1995
Effects of combinations of methanol and formic acid on rat embryos in culture.
    Teratology, 1998, Volume: 58, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Culture Techniques; Dose-Response Relationship, Drug; Drug Int

1998
Human placental acetylcholine content and release at parturition.
    Clinical and experimental pharmacology & physiology, 1988, Volume: 15, Issue:9

    Topics: Acetone; Acetylcholine; Female; Formates; Humans; Labor, Induced; Labor, Obstetric; Placenta; Pregna

1988