formic acid has been researched along with Huntington Disease in 3 studies
formic acid: RN given refers to parent cpd
formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fragmentation of expanded huntingtin in Huntington's disease must result from the operation of multiple proteolytic activities with little specificity and not from that of a specific endopeptidase; subsequent aggregation of the fragments by covalent and non-covalent bonds leads to the formation of the inclusions." | 1.33 | Purification of neuronal inclusions of patients with Huntington's disease reveals a broad range of N-terminal fragments of expanded huntingtin and insoluble polymers. ( Djian, P; Hoffner, G; Island, ML, 2005) |
| " Here we have report that, although expression of Huntingtin derivatives with a pathological poly(Q) expansion are innocuous in yeast, deletion of the flanking proline-rich region alters the shape and number of poly(Q) inclusions and unmasks toxic properties." | 1.33 | Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast. ( Bertolotti, A; Dehay, B, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iuchi, S | 1 |
| Hoffner, G | 2 |
| Verbeke, P | 1 |
| Djian, P | 2 |
| Green, H | 1 |
| Island, ML | 1 |
| Dehay, B | 1 |
| Bertolotti, A | 1 |
3 other studies available for formic acid and Huntington Disease
| Article | Year |
|---|---|
Oligomeric and polymeric aggregates formed by proteins containing expanded polyglutamine.
Topics: Animals; Blotting, Western; Brain; Cell Nucleus; Cerebellum; Cerebral Cortex; COS Cells; Cytosol; Di | 2003 |
Purification of neuronal inclusions of patients with Huntington's disease reveals a broad range of N-terminal fragments of expanded huntingtin and insoluble polymers.
Topics: Adolescent; Adult; Aged; Brain; Cerebral Cortex; Formates; Humans; Huntingtin Protein; Huntington Di | 2005 |
Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast.
Topics: Centrifugation, Density Gradient; Formates; Gene Deletion; Green Fluorescent Proteins; Heat-Shock Pr | 2006 |