formic acid has been researched along with Deficiency, Folic Acid in 17 studies
formic acid: RN given refers to parent cpd
formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration." | 7.78 | Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. ( Brosnan, JT; Brosnan, ME; Lamarre, SG; Molloy, AM; Reinke, SN; Sykes, BD, 2012) |
| "Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration." | 3.78 | Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration. ( Brosnan, JT; Brosnan, ME; Lamarre, SG; Molloy, AM; Reinke, SN; Sykes, BD, 2012) |
| " Monkeys were then reexposed to the highest exposure concentration, 900 ppm 14C-methanol, for a similar 2-hour period, and again the pharmacokinetic data described above were obtained." | 1.30 | Pharmacokinetics of methanol and formate in female cynomolgus monkeys exposed to methanol vapors. ( Bond, JA; Dorman, DC; Everitt, JI; Janszen, DB; Medinsky, MA; Moss, OR, 1997) |
| "Formaldehyde was not detected in blood or vitreous humor with or without DSF treatment, suggesting that formate is the toxic metabolite in methanol-induced retinal toxicity." | 1.29 | Role of retinal metabolism in methanol-induced retinal toxicity. ( Garner, CD; Lee, EW; Louis-Ferdinand, RT; Terzo, TS, 1995) |
| "Methanol was administered to rats by either the oral or inhalation route." | 1.29 | A rat model manifesting methanol-induced visual dysfunction suitable for both acute and long-term exposure studies. ( Garner, CD; Lee, EW; Terzo, TS, 1994) |
| "We attempted to develop a rodent model that exhibits characteristics of human methanol toxicities such as acidosis and visual dysfunction, which are correlated with an accumulation of formate, a toxic metabolite of methanol." | 1.29 | Animal model for the study of methanol toxicity: comparison of folate-reduced rat responses with published monkey data. ( Garner, CD; Lee, EW; Terzo, TS, 1994) |
| "Methanol treated (4 g/kg) Csb-FAD mice excreted 30." | 1.26 | Acute toxicity of methanol in the folate-deficient acatalasemic mouse. ( Smith, EN; Taylor, RT, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (47.06) | 18.7374 |
| 1990's | 5 (29.41) | 18.2507 |
| 2000's | 1 (5.88) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morrow, GP | 1 |
| MacMillan, L | 2 |
| Lamarre, SG | 3 |
| Young, SK | 1 |
| MacFarlane, AJ | 1 |
| Brosnan, ME | 3 |
| Brosnan, JT | 3 |
| Molloy, AM | 1 |
| Reinke, SN | 1 |
| Sykes, BD | 1 |
| Morrow, G | 1 |
| FATTERPAKER, P | 2 |
| MARFATIA, U | 2 |
| SREENIVASAN, A | 2 |
| FRIEDMANN, B | 2 |
| NAKADA, HI | 1 |
| WEINHOUSE, S | 2 |
| RABINOWITZ, JC | 1 |
| TABOR, H | 1 |
| Smith, EN | 1 |
| Taylor, RT | 1 |
| Garner, CD | 3 |
| Lee, EW | 3 |
| Terzo, TS | 3 |
| Louis-Ferdinand, RT | 1 |
| Dorman, DC | 2 |
| Moss, OR | 2 |
| Farris, GM | 1 |
| Janszen, D | 1 |
| Bond, JA | 2 |
| Medinsky, MA | 2 |
| Janszen, DB | 1 |
| Everitt, JI | 1 |
| Dow, JL | 1 |
| Green, T | 1 |
| Chanarin, I | 1 |
| Deacon, R | 1 |
| Lumb, M | 1 |
| Perry, J | 1 |
| Shane, B | 1 |
| Stokstad, EL | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Folic Acid Clinical Trial (FACT): Biomarker Subgroup Analysis[NCT03981029] | 51 participants (Actual) | Observational | 2011-12-19 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for formic acid and Deficiency, Folic Acid
| Article | Year |
|---|---|
Formate: an essential metabolite, a biomarker, or more?
Topics: Animals; Biomarkers; Carbon; Folic Acid; Folic Acid Deficiency; Formates; Humans; Vitamin B Deficien | 2013 |
Cobalamin-folate interrelations.
Topics: Anemia, Megaloblastic; Animals; Central Nervous System Diseases; Coenzymes; Folic Acid; Folic Acid D | 1989 |
Vitamin B12-folate interrelationships.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Amino Acids; Animals; Bone Marrow; Folic | 1985 |
14 other studies available for formic acid and Deficiency, Folic Acid
| Article | Year |
|---|---|
In vivo kinetics of formate metabolism in folate-deficient and folate-replete rats.
Topics: Animals; Choline; Dimethylglycine Dehydrogenase; Folic Acid; Folic Acid Deficiency; Formaldehyde; Fo | 2015 |
Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration.
Topics: Animals; Biomarkers; Brain; Folic Acid Deficiency; Formates; Homocysteine; Hyperhomocysteinemia; Liv | 2012 |
A sparing effect of formate or methanol on the impairment of creatine metabolism in folic acid deficiency.
Topics: Creatine; Ethanol; Folic Acid; Folic Acid Deficiency; Formates; Humans; Methanol | 1952 |
A study of the oxidation of formic acid in the folic acid-deficient rat.
Topics: Animals; Folic Acid; Folic Acid Deficiency; Formates; Humans; Oxidation-Reduction; Rats | 1954 |
A study of formate production in normal and folic acid-deficient rats.
Topics: Animals; Folic Acid; Folic Acid Deficiency; Formates; Rats | 1954 |
Rôle of folic acid and vitamin B12 in transmethylations. II. A sparing effect of formate or methanol on the impairment of creatine metabolism in folic acid deficiency.
Topics: Creatine; Ethanol; Folic Acid; Folic Acid Deficiency; Formates; Humans; Methanol; Vitamin B 12 | 1955 |
The urinary excretion of formic acid and formiminoglutamic acid in folic acid deficiency.
Topics: Body Fluids; Folic Acid; Folic Acid Deficiency; Formates; Formiminoglutamic Acid; Glutamates; Humans | 1958 |
Acute toxicity of methanol in the folate-deficient acatalasemic mouse.
Topics: Acatalasia; Animals; Diet; Female; Folic Acid Deficiency; Formates; Male; Methanol; Methionine; Mice | 1982 |
Role of retinal metabolism in methanol-induced retinal toxicity.
Topics: Animals; Chromatography, Gas; Disulfiram; Drug Interactions; Electroretinography; Folic Acid Deficie | 1995 |
A rat model manifesting methanol-induced visual dysfunction suitable for both acute and long-term exposure studies.
Topics: Administration, Inhalation; Administration, Oral; Animals; Chromatography, Gas; Disease Models, Anim | 1994 |
Pharmacokinetics of inhaled [14C]methanol and methanol-derived [14C]formate in normal and folate-deficient cynomolgus monkeys.
Topics: Administration, Inhalation; Animals; Carbon Dioxide; Chromatography, Gas; Disease Models, Animal; En | 1994 |
Animal model for the study of methanol toxicity: comparison of folate-reduced rat responses with published monkey data.
Topics: Administration, Inhalation; Administration, Oral; Aerosols; Animals; Disease Models, Animal; Dose-Re | 1994 |
Pharmacokinetics of methanol and formate in female cynomolgus monkeys exposed to methanol vapors.
Topics: Adult; Air Pollutants; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Female; Foli | 1997 |
Trichloroethylene induced vitamin B(12) and folate deficiency leads to increased formic acid excretion in the rat.
Topics: Anesthetics, Inhalation; Animals; Bacteria; Biotransformation; Catalase; Folic Acid Deficiency; Form | 2000 |