formic acid has been researched along with Akinetic-Rigid Variant of Huntington Disease in 3 studies
formic acid: RN given refers to parent cpd
formic acid : The simplest carboxylic acid, containing a single carbon. Occurs naturally in various sources including the venom of bee and ant stings, and is a useful organic synthetic reagent. Principally used as a preservative and antibacterial agent in livestock feed. Induces severe metabolic acidosis and ocular injury in human subjects.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fragmentation of expanded huntingtin in Huntington's disease must result from the operation of multiple proteolytic activities with little specificity and not from that of a specific endopeptidase; subsequent aggregation of the fragments by covalent and non-covalent bonds leads to the formation of the inclusions." | 1.33 | Purification of neuronal inclusions of patients with Huntington's disease reveals a broad range of N-terminal fragments of expanded huntingtin and insoluble polymers. ( Djian, P; Hoffner, G; Island, ML, 2005) |
| " Here we have report that, although expression of Huntingtin derivatives with a pathological poly(Q) expansion are innocuous in yeast, deletion of the flanking proline-rich region alters the shape and number of poly(Q) inclusions and unmasks toxic properties." | 1.33 | Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast. ( Bertolotti, A; Dehay, B, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Iuchi, S | 1 |
| Hoffner, G | 2 |
| Verbeke, P | 1 |
| Djian, P | 2 |
| Green, H | 1 |
| Island, ML | 1 |
| Dehay, B | 1 |
| Bertolotti, A | 1 |
3 other studies available for formic acid and Akinetic-Rigid Variant of Huntington Disease
| Article | Year |
|---|---|
Oligomeric and polymeric aggregates formed by proteins containing expanded polyglutamine.
Topics: Animals; Blotting, Western; Brain; Cell Nucleus; Cerebellum; Cerebral Cortex; COS Cells; Cytosol; Di | 2003 |
Purification of neuronal inclusions of patients with Huntington's disease reveals a broad range of N-terminal fragments of expanded huntingtin and insoluble polymers.
Topics: Adolescent; Adult; Aged; Brain; Cerebral Cortex; Formates; Humans; Huntingtin Protein; Huntington Di | 2005 |
Critical role of the proline-rich region in Huntingtin for aggregation and cytotoxicity in yeast.
Topics: Centrifugation, Density Gradient; Formates; Gene Deletion; Green Fluorescent Proteins; Heat-Shock Pr | 2006 |