formaldehyde has been researched along with Lewy Body Disease in 4 studies
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy
Lewy Body Disease: A neurodegenerative disease characterized by dementia, mild parkinsonism, and fluctuations in attention and alertness. The neuropsychiatric manifestations tend to precede the onset of bradykinesia, MUSCLE RIGIDITY, and other extrapyramidal signs. DELUSIONS and visual HALLUCINATIONS are relatively frequent in this condition. Histologic examination reveals LEWY BODIES in the CEREBRAL CORTEX and BRAIN STEM. SENILE PLAQUES and other pathologic features characteristic of ALZHEIMER DISEASE may also be present. (From Neurology 1997;48:376-380; Neurology 1996;47:1113-1124)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We show that fixed tissue from Parkinson's disease (PD) and incidental Lewy body disease (ILBD) seeds the aggregation of monomeric αSyn into fibrillar assemblies." | 1.62 | Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease. ( Bousset, L; Braak, H; Del Tredici, K; Duyckaerts, C; Fenyi, A; Melki, R, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kim, A | 1 |
| Martinez-Valbuena, I | 1 |
| Li, J | 1 |
| Lang, AE | 1 |
| Kovacs, GG | 1 |
| Ruesink, H | 1 |
| Reimer, L | 1 |
| Gregersen, E | 1 |
| Moeller, A | 1 |
| Betzer, C | 1 |
| Jensen, PH | 1 |
| Fenyi, A | 1 |
| Duyckaerts, C | 1 |
| Bousset, L | 1 |
| Braak, H | 1 |
| Del Tredici, K | 1 |
| Melki, R | 1 |
| Beach, TG | 1 |
| White, CL | 1 |
| Hamilton, RL | 1 |
| Duda, JE | 1 |
| Iwatsubo, T | 1 |
| Dickson, DW | 1 |
| Leverenz, JB | 1 |
| Roncaroli, F | 1 |
| Buttini, M | 1 |
| Hladik, CL | 1 |
| Sue, LI | 1 |
| Noorigian, JV | 1 |
| Adler, CH | 1 |
4 other studies available for formaldehyde and Lewy Body Disease
| Article | Year |
|---|---|
Disease-Specific α-Synuclein Seeding in Lewy Body Disease and Multiple System Atrophy Are Preserved in Formaldehyde-Fixed Paraffin-Embedded Human Brain.
Topics: alpha-Synuclein; Brain; Formaldehyde; Humans; Lewy Body Disease; Multiple System Atrophy; Paraffin; | 2023 |
Stabilization of α-synuclein oligomers using formaldehyde.
Topics: alpha-Synuclein; Amyloid; Formaldehyde; Humans; Lewy Body Disease; Multiple System Atrophy; Parkinso | 2019 |
Seeding Propensity and Characteristics of Pathogenic αSyn Assemblies in Formalin-Fixed Human Tissue from the Enteric Nervous System, Olfactory Bulb, and Brainstem in Cases Staged for Parkinson's Disease.
Topics: Adult; Aged; Aged, 80 and over; alpha-Synuclein; Brain Stem; Enteric Nervous System; Female; Formald | 2021 |
Evaluation of alpha-synuclein immunohistochemical methods used by invited experts.
Topics: Aged; Aged, 80 and over; alpha-Synuclein; Alzheimer Disease; Formaldehyde; Humans; Immunohistochemis | 2008 |