formaldehyde has been researched along with Facial Pain in 71 studies
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy
Facial Pain: Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present study explored the interaction between histaminergic and opioidergic systems at the level of the hippocampus in modulation of orofacial pain by intra-hippocampal microinjections of histamine, pyrilamine (an antagonist of histamine H(1) receptors), ranitidine (an antagonist of histamine H(2) receptors), morphine (an opioid receptor agonist) and naloxone (an opioid receptor antagonist) in separate and combined treatments." | 7.77 | Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats. ( Erfanparast, A; Farshid, AA; Khalilzadeh, E; Tamaddonfard, E, 2011) |
| "The present study was planned to evaluate the role of curcumin in the formalin-induced orofacial pain in rats that mimics typical human orofacial pain." | 7.75 | Evaluation of antihyperalgesic effect of curcumin on formalin-induced orofacial pain in rat. ( Chakrabarti, A; Hota, D; Joshi, R; Mittal, N, 2009) |
| "The effects of alpha,beta-amyrin, a pentacyclic triterpene isolated from Protium heptaphylum was investigated on rat model of orofacial pain induced by formalin or capsaicin." | 7.74 | Antinoceptive effect of triterpenoid alpha,beta-amyrin in rats on orofacial pain induced by formalin and capsaicin. ( Chaves, MH; Cunha, GM; Guedes, MA; Holanda Pinto, SA; Pinto, LM; Rao, VS; Santos, FA, 2008) |
| "The present study evaluates the possible role of dihydropyridine calcium channel antagonist nimodipine on diclofenac analgesia in formalin-induced facial pain model in rats." | 7.72 | Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats. ( Hota, D; Pandhi, P, 2004) |
| " Thus, the purpose of the present studies was to evaluate whether the neuronal nicotinic receptor agonist epibatidine possesses antihyperalgesic activity in the formalin model of facial pain." | 7.71 | Antihyperalgesic activity of epibatidine in the formalin model of facial pain. ( Clark, TM; Flores, CM; Gilbert, SD, 2001) |
| "The present study compared the peripheral and systemic antinociceptive effect of morphine on formalin-induced facial pain behavior in the rat." | 7.69 | The peripheral antinociceptive effect of morphine in a rat model of facial pain. ( Eisenberg, E; Strassman, AM; Vos, BP, 1996) |
| "In humans, orofacial pain has a high prevalence and is often difficult to treat." | 5.48 | Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels. ( Dožić, BS; Dožić, IS; Karadžić, BV; Milovanović, AP; Prostran, MŠ; Savić Vujović, KR; Srebro, DP; Vučković, SM, 2018) |
| "Orofacial pain was induced by subcutaneous injection of formalin (1." | 5.40 | Role of hydrogen sulfide in the formalin-induced orofacial pain in rats. ( Araujo, RM; Azevedo, LU; Branco, LG; Donatti, AF; Leite-Panissi, CA; Soriano, RN, 2014) |
| "The objective of this study is to test the hypothesis that citral modulates orofacial pain using two experimental models: formalin-induced hyperalgesia in the vibrissae area and during persistent temporomandibular hypernociception using Complete Freund's Adjuvant - CFA test." | 4.31 | Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats. ( Branco, LGS; Cárnio, EC; Emilio-Silva, MT; Garcia, FS; Hiruma-Lima, CA; Jesus, AA; Nascimento, GC; Santos, BM; Santos, WS; Solon, IG, 2023) |
| "This study aimed to evaluate the antinociceptive effect of oleanolic acid using adult zebrafish models of orofacial pain." | 3.91 | Oleanolic acid promotes orofacial antinociception in adult zebrafish (Danio rerio) through TRPV1 receptors. ( Alves, YA; Campos, AR; Coelho, RF; Magalhaes, FEA; Santos, SAAR; Soares, ICR; Tavares, KCS; Vieira-Neto, AE, 2019) |
| "The purposes of this study were to evaluate the anti-nociceptive effect of oral and topical administration of (-)-α-bisabolol (BISA) in rodent models of formalin- or cinnamaldehyde-induced orofacial pain and to explore the inhibitory mechanisms involved." | 3.85 | (-)-α-Bisabolol reduces orofacial nociceptive behavior in rodents. ( Campos, AR; da Costa, FN; de Vasconcellos Abdon, AP; Duailibe, MA; Melo, LT; Pessoa, LM; Vieira-Neto, AE, 2017) |
| " This study was designed to investigate the effects of local peripheral (into upper lip) and systemic injection of vitamin B12 and diclofenac on the orofacial pain." | 3.80 | Systemic and local peripheral injections of vitamin B12 suppressed orofacial nociception induced by formalin in rats. ( Dabbaghi, M; Erfanparast, A; Escort, M; Kazemi-Shojaei, S; Maroufi, S; Taati, M; Tamaddonfard, E, 2014) |
| "The antinociceptive activity was investigated in mice orally treated with different doses of the CHEE (50, 100, and 200 mg/kg) and morphine (5 mg/kg) using formalin, glutamate, and capsaicin orofacial pain models using." | 3.79 | Orofacial antinociceptive effect and antioxidant properties of the hydroethanol extract of Hyptis fruticosa salmz ex Benth. ( Araújo, BS; Damascena, NP; de Lima, AC; de Santana, MT; Dias, AS; dos S Estevam, C; Fernandes, XA; Lima, CA; Melo, M; Paixão, MS; Porto, YC; Quintans Júnior, LJ; Santos, CC, 2013) |
| "The present study explored the interaction between histaminergic and opioidergic systems at the level of the hippocampus in modulation of orofacial pain by intra-hippocampal microinjections of histamine, pyrilamine (an antagonist of histamine H(1) receptors), ranitidine (an antagonist of histamine H(2) receptors), morphine (an opioid receptor agonist) and naloxone (an opioid receptor antagonist) in separate and combined treatments." | 3.77 | Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats. ( Erfanparast, A; Farshid, AA; Khalilzadeh, E; Tamaddonfard, E, 2011) |
| " In the present study, the effect of microinjection of histamine, mepyramine (a histamine H(1) receptor antagonist) and ranitidine (a histamine H(2) receptor antagonist) into the dorsal hippocampus was investigated on a model of orofacial pain in rats." | 3.76 | Effect of microinjection of histamine into the dorsal hippocampus on the orofacial formalin-induced pain in rats. ( Erfanparast, A; Farshid, AA; Khalilzadeh, E; Tamaddonfard, E, 2010) |
| "The present study was planned to evaluate the role of curcumin in the formalin-induced orofacial pain in rats that mimics typical human orofacial pain." | 3.75 | Evaluation of antihyperalgesic effect of curcumin on formalin-induced orofacial pain in rat. ( Chakrabarti, A; Hota, D; Joshi, R; Mittal, N, 2009) |
| "The effects of alpha,beta-amyrin, a pentacyclic triterpene isolated from Protium heptaphylum was investigated on rat model of orofacial pain induced by formalin or capsaicin." | 3.74 | Antinoceptive effect of triterpenoid alpha,beta-amyrin in rats on orofacial pain induced by formalin and capsaicin. ( Chaves, MH; Cunha, GM; Guedes, MA; Holanda Pinto, SA; Pinto, LM; Rao, VS; Santos, FA, 2008) |
| "The present study evaluates the possible role of dihydropyridine calcium channel antagonist nimodipine on diclofenac analgesia in formalin-induced facial pain model in rats." | 3.72 | Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats. ( Hota, D; Pandhi, P, 2004) |
| " Thus, the purpose of the present studies was to evaluate whether the neuronal nicotinic receptor agonist epibatidine possesses antihyperalgesic activity in the formalin model of facial pain." | 3.71 | Antihyperalgesic activity of epibatidine in the formalin model of facial pain. ( Clark, TM; Flores, CM; Gilbert, SD, 2001) |
| "The present study compared the peripheral and systemic antinociceptive effect of morphine on formalin-induced facial pain behavior in the rat." | 3.69 | The peripheral antinociceptive effect of morphine in a rat model of facial pain. ( Eisenberg, E; Strassman, AM; Vos, BP, 1996) |
| "Physiology of orofacial pain pathways embraces primary afferent neurons, pathologic changes in the trigeminal ganglion, brainstem nociceptive neurons, and higher brain function regulating orofacial nociception." | 1.72 | Peripheral Purinergic Modulation in Pediatric Orofacial Inflammatory Pain Affects Brainstem Nitroxidergic System: A Translational Research. ( Ballini, A; Boccellino, M; Borsani, E; Buffoli, B; Cantore, S; Cosola, MD; Di Domenico, M; Dibello, V; Muzio, LL; Nocini, R; Rezzani, R; Rodella, LF; Scacco, S, 2022) |
| "Carbachol was used for chemical stimulation of orexinergic neurons in the LH." | 1.56 | Involvement of Orexinergic System Within the Nucleus Accumbens in Pain Modulatory Role of the Lateral Hypothalamus in Orofacial Pain Model. ( Haghparast, A; Matini, T; Rahban, M; Rezaee, L; Tehranchi, A, 2020) |
| "Although the magnitude of the hyperalgesia is dependent on the intensity of the conditioning stimulus, we find that the direction of effect is dependent on the effective test stimulus intensity, with lower-intensity stimuli leading to hyperalgesia and higher-intensity stimuli leading to hypoalgesia." | 1.51 | Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity. ( Austin, JS; Coderre, TJ; Diamond, L; George, N; Macintyre, LC; Martin, LJ; Meluban, L; Mogil, JS; Sotocinal, SG; Tansley, SN, 2019) |
| "In humans, orofacial pain has a high prevalence and is often difficult to treat." | 1.48 | Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels. ( Dožić, BS; Dožić, IS; Karadžić, BV; Milovanović, AP; Prostran, MŠ; Savić Vujović, KR; Srebro, DP; Vučković, SM, 2018) |
| "Orofacial pain is one of the most common pain conditions and compromises the quality of life of the sufferer." | 1.48 | Analgesic activities of the mixed opioid and NPFF receptors agonist DN-9 in a mouse model of formalin-induced orofacial inflammatory pain. ( Chen, D; Fang, Q; Guo, Y; Shi, X; Xiao, J; Xu, B; Zhang, M; Zhang, Q; Zhang, T; Zhao, W; Zheng, T, 2018) |
| " To obtain pharmacokinetic data, KA-1, KA-2 and KYNA concentrations were measured following KA-1 or KA-2 injection." | 1.46 | A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study. ( Bajtai, A; Bohár, Z; Fejes-Szabó, A; Fülöp, F; Laborc, K; László, AM; Mándity, I; Nagy-Grócz, G; Párdutz, Á; Szatmári, I; Szentirmai, M; Vécsei, L; Veres, G; Zádori, D, 2017) |
| "Orofacial pain is a common clinical symptom that is accompanied by tooth pain, migraine and gingivitis." | 1.43 | Acid-sensing ion channels in trigeminal ganglion neurons innervating the orofacial region contribute to orofacial inflammatory pain. ( Chen, JG; Fang, P; Fu, H; Hu, ZL; Jin, Y; Ni, M; Wang, F; Yu, XW; Zheng, JY; Zhou, HY; Zhou, J, 2016) |
| "Orofacial pain was induced by subcutaneous injection of a diluted formalin solution (50μl, 1." | 1.42 | The role of nicotinic acetylcholine and opioid systems of the ventral orbital cortex in modulation of formalin-induced orofacial pain in rats. ( Farshid, AA; Tamaddonfard, E; Yousofizadeh, S, 2015) |
| "Levetiracetam is an antiepileptic drug with analgesic efficacy shown in pain models and small clinical trials." | 1.42 | The effects of levetiracetam, sumatriptan, and caffeine in a rat model of trigeminal pain: interactions in 2-component combinations. ( Micov, AM; Pecikoza, UB; Popović, BV; Stepanović-Petrović, RM; Tomić, MA, 2015) |
| "Probenecid has been widely used in the treatment of gout, but evidence suggests that it may also have antinociceptive effects in different inflammatory and pain conditions." | 1.42 | Effect of probenecid on the pain-related behaviour and morphological markers in orofacial formalin test of the rat. ( Bohár, Z; Fejes-Szabó, A; Nagy-Grócz, G; Párdutz, Á; Pődör, B; Tajti, J; Tar, L; Toldi, J; Vámos, E; Vécsei, L, 2015) |
| "However, orofacial heat and cold hyperalgesia, induced by carrageenan injected into the upper lip (50 µg/50 μl), was abolished by previous intraganglionar RTX treatment." | 1.40 | Intraganglionar resiniferatoxin prevents orofacial inflammatory and neuropathic hyperalgesia. ( Chichorro, JG; Cruz, LS; Kopruszinski, CM, 2014) |
| "The treatment of orofacial pain remains a major challenge for modern medicine." | 1.40 | β-cyclodextrin complex containing Lippia grata leaf essential oil reduces orofacial nociception in mice - evidence of possible involvement of descending inhibitory pain modulation pathway. ( Alves, PB; Araújo, AA; Bonjardim, LR; de Lucca Júnior, W; Lucchese, AM; Menezes, PP; Quintans, JS; Quintans-Júnior, LJ; Santos, MR; Siqueira-Lima, PS, 2014) |
| "To induce orofacial pain, 50 μl of 1% formalin was subcutaneously injected into the left side of the upper lip." | 1.40 | Interaction between the dopaminergic and opioidergic systems in dorsal hippocampus in modulation of formalin-induced orofacial pain in rats. ( Haghparast, A; Pahlevani, P; Reisi, Z; Shamsizadeh, A, 2014) |
| "Orofacial pain was induced by subcutaneous injection of formalin (1." | 1.40 | Role of hydrogen sulfide in the formalin-induced orofacial pain in rats. ( Araujo, RM; Azevedo, LU; Branco, LG; Donatti, AF; Leite-Panissi, CA; Soriano, RN, 2014) |
| "Dexketoprofen was more potent in phase I (19." | 1.37 | Synergism between dexketoprofen and meloxicam in an orofacial formalin test was not modified by opioid antagonists. ( Gonzalez, C; Miranda, HF; Noriega, V; Prieto, JC; Zegpi, C, 2011) |
| "Both midazolam and morphine were effective in reducing the nociceptive response of the second phase of this biphasic pain test." | 1.28 | Intrathecal midazolam versus intrathecal morphine in orofacial nociception: an experimental study in rats. ( Aigouy, L; Fondras, JC; Pajot, J; Schoeffler, P; Woda, A, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (2.82) | 18.7374 |
| 1990's | 6 (8.45) | 18.2507 |
| 2000's | 19 (26.76) | 29.6817 |
| 2010's | 40 (56.34) | 24.3611 |
| 2020's | 4 (5.63) | 2.80 |
| Authors | Studies |
|---|---|
| Orr, DL | 1 |
| Borsani, E | 1 |
| Ballini, A | 1 |
| Buffoli, B | 1 |
| Muzio, LL | 1 |
| Di Domenico, M | 1 |
| Boccellino, M | 1 |
| Scacco, S | 1 |
| Nocini, R | 1 |
| Dibello, V | 1 |
| Rezzani, R | 1 |
| Cantore, S | 1 |
| Rodella, LF | 1 |
| Cosola, MD | 1 |
| Tajabadi, A | 1 |
| Abbasnejad, M | 2 |
| Kooshki, R | 1 |
| Esmaeili-Mahani, S | 2 |
| Raoof, M | 2 |
| Lobbezoo, F | 1 |
| Santos, BM | 1 |
| Santos, WS | 1 |
| Solon, IG | 1 |
| Garcia, FS | 1 |
| Emilio-Silva, MT | 1 |
| Jesus, AA | 1 |
| Hiruma-Lima, CA | 1 |
| Nascimento, GC | 1 |
| Cárnio, EC | 1 |
| Branco, LGS | 1 |
| Haghparast, A | 7 |
| Matini, T | 1 |
| Rezaee, L | 1 |
| Rahban, M | 1 |
| Tehranchi, A | 1 |
| Shafiei, I | 2 |
| Alizadeh, AM | 1 |
| Ezzatpanah, S | 2 |
| Srebro, DP | 1 |
| Vučković, SM | 1 |
| Dožić, IS | 1 |
| Dožić, BS | 1 |
| Savić Vujović, KR | 1 |
| Milovanović, AP | 1 |
| Karadžić, BV | 1 |
| Prostran, MŠ | 1 |
| Vatankhah, M | 1 |
| Zarepour, L | 1 |
| Zhang, T | 1 |
| Zhao, W | 1 |
| Zhang, M | 1 |
| Xu, B | 1 |
| Shi, X | 1 |
| Zhang, Q | 1 |
| Guo, Y | 1 |
| Xiao, J | 1 |
| Chen, D | 1 |
| Zheng, T | 1 |
| Fang, Q | 1 |
| Soares, ICR | 1 |
| Santos, SAAR | 1 |
| Coelho, RF | 1 |
| Alves, YA | 1 |
| Vieira-Neto, AE | 2 |
| Tavares, KCS | 1 |
| Magalhaes, FEA | 1 |
| Campos, AR | 2 |
| Tansley, SN | 1 |
| Macintyre, LC | 1 |
| Diamond, L | 1 |
| Sotocinal, SG | 1 |
| George, N | 1 |
| Meluban, L | 1 |
| Austin, JS | 1 |
| Coderre, TJ | 1 |
| Martin, LJ | 1 |
| Mogil, JS | 1 |
| Erfanparast, A | 5 |
| Escort, M | 1 |
| Tamaddonfard, E | 6 |
| Maroufi, S | 1 |
| Kazemi-Shojaei, S | 1 |
| Dabbaghi, M | 1 |
| Taati, M | 2 |
| Siqueira-Lima, PS | 1 |
| Araújo, AA | 2 |
| Lucchese, AM | 1 |
| Quintans, JS | 1 |
| Menezes, PP | 1 |
| Alves, PB | 1 |
| de Lucca Júnior, W | 1 |
| Santos, MR | 1 |
| Bonjardim, LR | 2 |
| Quintans-Júnior, LJ | 3 |
| Roh, DH | 2 |
| Yoon, SY | 2 |
| Cruz, LS | 1 |
| Kopruszinski, CM | 1 |
| Chichorro, JG | 2 |
| Donatti, AF | 1 |
| Araujo, RM | 1 |
| Soriano, RN | 1 |
| Azevedo, LU | 1 |
| Leite-Panissi, CA | 1 |
| Branco, LG | 1 |
| Reisi, Z | 1 |
| Pahlevani, P | 1 |
| Shamsizadeh, A | 1 |
| Fejes-Szabó, A | 3 |
| Bohár, Z | 3 |
| Nagy-Grócz, G | 3 |
| Vámos, E | 1 |
| Tar, L | 2 |
| Pődör, B | 1 |
| Tajti, J | 1 |
| Toldi, J | 1 |
| Vécsei, L | 3 |
| Párdutz, Á | 3 |
| Maegawa, H | 1 |
| Morimoto, Y | 1 |
| Kudo, C | 1 |
| Hanamoto, H | 1 |
| Boku, A | 1 |
| Sugimura, M | 1 |
| Kato, T | 1 |
| Yoshida, A | 1 |
| Niwa, H | 1 |
| Tomić, MA | 1 |
| Pecikoza, UB | 1 |
| Micov, AM | 1 |
| Popović, BV | 1 |
| Stepanović-Petrović, RM | 1 |
| Yousofizadeh, S | 1 |
| Farshid, AA | 3 |
| Lee, H | 1 |
| De Vito, V | 1 |
| Giorgi, M | 1 |
| Yun, H | 1 |
| Dabaghi, M | 1 |
| László, AM | 2 |
| Büki, A | 1 |
| Szabadi, N | 1 |
| Vraukó, V | 1 |
| Kang, SY | 1 |
| Kim, HW | 1 |
| Kim, HC | 1 |
| Fu, H | 1 |
| Fang, P | 1 |
| Zhou, HY | 1 |
| Zhou, J | 1 |
| Yu, XW | 1 |
| Ni, M | 1 |
| Zheng, JY | 1 |
| Jin, Y | 1 |
| Chen, JG | 1 |
| Wang, F | 1 |
| Hu, ZL | 1 |
| Macedo, CG | 1 |
| Fanton, LE | 1 |
| Fischer, L | 1 |
| Tambeli, CH | 1 |
| Barreto, RSS | 1 |
| Quintans, JSS | 1 |
| Amarante, RKL | 1 |
| Nascimento, TS | 1 |
| Amarante, RS | 1 |
| Barreto, AS | 1 |
| Pereira, EWM | 1 |
| Duarte, MC | 1 |
| Coutinho, HDM | 1 |
| Menezes, IRA | 1 |
| Zengin, G | 1 |
| Aktumsek, A | 1 |
| Bahaaddini, M | 1 |
| Khatamsaz, S | 1 |
| Veres, G | 1 |
| Zádori, D | 1 |
| Bajtai, A | 1 |
| Mándity, I | 1 |
| Szentirmai, M | 1 |
| Laborc, K | 1 |
| Szatmári, I | 1 |
| Fülöp, F | 1 |
| Melo, LT | 1 |
| Duailibe, MA | 1 |
| Pessoa, LM | 1 |
| da Costa, FN | 1 |
| de Vasconcellos Abdon, AP | 1 |
| Barreras-Espinoza, I | 1 |
| Soto-Zambrano, JA | 1 |
| Serafín-Higuera, N | 1 |
| Zapata-Morales, R | 1 |
| Alonso-Castro, Á | 1 |
| Bologna-Molina, R | 1 |
| Granados-Soto, V | 1 |
| Isiordia-Espinoza, MA | 1 |
| Nemati, S | 1 |
| Tomaz-Morais, JF | 1 |
| Braga, RM | 1 |
| de Sousa, FB | 1 |
| de Sousa, DP | 2 |
| deM Pordeus, LC | 1 |
| de Almeida, RN | 1 |
| de Castro, RD | 1 |
| Seadi Pereira, PJ | 1 |
| Noronha Dornelles, F | 1 |
| Santiago Santos, D | 1 |
| Batista Calixto, J | 1 |
| Bueno Morrone, F | 1 |
| Campos, MM | 1 |
| Mittal, N | 1 |
| Joshi, R | 1 |
| Hota, D | 2 |
| Chakrabarti, A | 1 |
| Lu, X | 1 |
| Geng, X | 1 |
| Zhang, L | 1 |
| Zeng, Y | 1 |
| Dong, H | 1 |
| Yu, H | 1 |
| Burgos, E | 1 |
| Pascual, D | 1 |
| Martín, MI | 1 |
| Goicoechea, C | 1 |
| Foo, H | 1 |
| Crabtree, K | 1 |
| Thrasher, A | 1 |
| Mason, P | 1 |
| Wu, LA | 1 |
| Huang, J | 1 |
| Wang, W | 2 |
| Wang, XJ | 1 |
| Wu, SX | 1 |
| Khalilzadeh, E | 2 |
| Yang, GY | 1 |
| Woo, YW | 1 |
| Park, MK | 1 |
| Bae, YC | 1 |
| Ahn, DK | 2 |
| Bonfa, E | 1 |
| Melo, MS | 1 |
| Onofre, AC | 1 |
| Gelain, DP | 1 |
| Gonçalves, JC | 1 |
| Araújo, DA | 1 |
| Almeida, JR | 1 |
| Bornhof, M | 1 |
| Ihmsen, H | 1 |
| Schwilden, H | 1 |
| Yeomans, DC | 1 |
| Tzabazis, A | 1 |
| Gonzalez, C | 1 |
| Zegpi, C | 1 |
| Noriega, V | 2 |
| Prieto, JC | 2 |
| Miranda, HF | 2 |
| Zepeda, RJ | 1 |
| Sierralta, F | 1 |
| Zhu, DW | 1 |
| Li, CY | 1 |
| Zhang, J | 1 |
| Liu, HC | 1 |
| Matak, I | 1 |
| Stracenski, I | 1 |
| Lacković, Z | 1 |
| de Lima, AC | 1 |
| Paixão, MS | 1 |
| Melo, M | 1 |
| de Santana, MT | 1 |
| Damascena, NP | 1 |
| Dias, AS | 1 |
| Porto, YC | 1 |
| Fernandes, XA | 1 |
| Santos, CC | 1 |
| Lima, CA | 1 |
| Quintans Júnior, LJ | 1 |
| dos S Estevam, C | 1 |
| Araújo, BS | 1 |
| Luccarini, P | 4 |
| Henry, M | 1 |
| Alvarez, P | 1 |
| Gaydier, AM | 3 |
| Dallel, R | 5 |
| Lorenzetti, BB | 1 |
| Zampronio, AR | 1 |
| Perrier, L | 1 |
| Dégoulange, C | 1 |
| Raboisson, P | 2 |
| Pandhi, P | 1 |
| Okamoto, K | 3 |
| Imbe, H | 3 |
| Tashiro, A | 1 |
| Kumabe, S | 1 |
| Senba, E | 3 |
| Zeredo, JL | 2 |
| Sasaki, KM | 1 |
| Takeuchi, Y | 1 |
| Toda, K | 2 |
| Lee, KR | 1 |
| Lee, HJ | 1 |
| Kim, SK | 1 |
| Choi, HS | 1 |
| Lim, EJ | 1 |
| Park, JS | 1 |
| Kimura, A | 2 |
| Donishi, T | 2 |
| Tamai, Y | 2 |
| Childeric, A | 1 |
| Voisin, D | 1 |
| Miura, K | 1 |
| Ohara, T | 1 |
| Okada, Y | 1 |
| Sumikawa, K | 1 |
| Holanda Pinto, SA | 1 |
| Pinto, LM | 1 |
| Guedes, MA | 1 |
| Cunha, GM | 1 |
| Chaves, MH | 1 |
| Santos, FA | 1 |
| Rao, VS | 1 |
| Eisenberg, E | 2 |
| Vos, BP | 3 |
| Strassman, AM | 2 |
| Hans, G | 1 |
| Adriaensen, H | 1 |
| Cadet, R | 1 |
| Duale, C | 1 |
| Woda, A | 2 |
| Gilbert, SD | 1 |
| Clark, TM | 1 |
| Flores, CM | 1 |
| Aigouy, L | 1 |
| Fondras, JC | 1 |
| Pajot, J | 2 |
| Schoeffler, P | 1 |
| Clavelou, P | 1 |
1 review available for formaldehyde and Facial Pain
| Article | Year |
|---|---|
The orofacial formalin test.
Topics: Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Injections, Subcutaneous; Lip; Pain Meas | 2004 |
1 trial available for formaldehyde and Facial Pain
| Article | Year |
|---|---|
Orofacial antinociceptive activity of (S)-(-)-perillyl alcohol in mice: a randomized, controlled and triple-blind study.
Topics: Animals; Capsaicin; Facial Pain; Formaldehyde; Glutamic Acid; Male; Mice; Monoterpenes; Morphine; Pa | 2017 |
69 other studies available for formaldehyde and Facial Pain
| Article | Year |
|---|---|
Paresthesia of the trigeminal nerve secondary to endodontic manipulation with N2.
Topics: Adult; Cranial Nerve Diseases; Dental Materials; Dental Restoration, Permanent; Endodontics; Facial | 1985 |
Peripheral Purinergic Modulation in Pediatric Orofacial Inflammatory Pain Affects Brainstem Nitroxidergic System: A Translational Research.
Topics: Adolescent; Animals; Brain Stem; Child; Facial Pain; Formaldehyde; Humans; Mice; Translational Resea | 2022 |
Repeated gentle handling or maternal deprivation during the neonatal stage increases adult male rats' baseline orofacial pain responsiveness.
Topics: Animals; Capsaicin; Facial Pain; Formaldehyde; Male; Maternal Deprivation; Nitroglycerin; Nociceptio | 2023 |
Orofacial anti-hypernociceptive effect of citral in acute and persistent inflammatory models in rats.
Topics: Analgesics; Animals; Facial Pain; Formaldehyde; Hyperalgesia; Inflammation; Rats | 2023 |
Involvement of Orexinergic System Within the Nucleus Accumbens in Pain Modulatory Role of the Lateral Hypothalamus in Orofacial Pain Model.
Topics: Analgesics, Non-Narcotic; Animals; Benzoxazoles; Carbachol; Facial Pain; Formaldehyde; Hypothalamic | 2020 |
Blockade of the orexin receptors in the CA1 region of hippocampus decreased the lateral hypothalamic-induced antinociceptive responses in the model of orofacial formalin test in the rats.
Topics: Analgesics; Animals; Benzoxazoles; CA1 Region, Hippocampal; Facial Pain; Formaldehyde; Isoquinolines | 2018 |
Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels.
Topics: Analgesics; Animals; Behavior, Animal; Biomarkers; Creatine Kinase; Disease Models, Animal; Facial P | 2018 |
Role of D1- and D2-like dopaminergic receptors in the nucleus accumbens in modulation of formalin-induced orofacial pain: Involvement of lateral hypothalamus.
Topics: Analgesics; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Carbachol; Disease Models, Anim | 2018 |
Analgesic activities of the mixed opioid and NPFF receptors agonist DN-9 in a mouse model of formalin-induced orofacial inflammatory pain.
Topics: Analgesics, Opioid; Animals; Blotting, Western; Facial Pain; Female; Fluorescent Antibody Technique; | 2018 |
Oleanolic acid promotes orofacial antinociception in adult zebrafish (Danio rerio) through TRPV1 receptors.
Topics: Acetanilides; Analgesics; Animals; Behavior, Animal; Binding Sites; Capsaicin; Facial Pain; Formalde | 2019 |
Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity.
Topics: Acetic Acid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Formald | 2019 |
Systemic and local peripheral injections of vitamin B12 suppressed orofacial nociception induced by formalin in rats.
Topics: Animals; Diclofenac; Facial Pain; Formaldehyde; Injections, Subcutaneous; Male; Nociception; Rats; R | 2014 |
β-cyclodextrin complex containing Lippia grata leaf essential oil reduces orofacial nociception in mice - evidence of possible involvement of descending inhibitory pain modulation pathway.
Topics: Animals; beta-Cyclodextrins; Capsaicin; Facial Pain; Formaldehyde; Glutamic Acid; Lippia; Male; Mice | 2014 |
Sigma-1 receptor antagonist, BD1047 reduces nociceptive responses and phosphorylation of p38 MAPK in mice orofacial formalin model.
Topics: Analgesics; Animals; Disease Models, Animal; Ethylenediamines; Facial Pain; Formaldehyde; Lip; Male; | 2014 |
Intraganglionar resiniferatoxin prevents orofacial inflammatory and neuropathic hyperalgesia.
Topics: Animals; Capsaicin; Carrageenan; Cold Temperature; Disease Models, Animal; Diterpenes; Facial Pain; | 2014 |
Role of hydrogen sulfide in the formalin-induced orofacial pain in rats.
Topics: Animals; Behavior, Animal; Calcium Channels, T-Type; Facial Pain; Formaldehyde; Hydrogen Sulfide; KA | 2014 |
Interaction between the dopaminergic and opioidergic systems in dorsal hippocampus in modulation of formalin-induced orofacial pain in rats.
Topics: Animals; Benzazepines; CA1 Region, Hippocampal; Dopamine; Dopamine Agonists; Dopamine Antagonists; F | 2014 |
Effect of probenecid on the pain-related behaviour and morphological markers in orofacial formalin test of the rat.
Topics: Analgesics; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Injections, Intraperitoneal; | 2015 |
Neural mechanism underlying hyperalgesic response to orofacial pain in Parkinson's disease model rats.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Facial Pain; Formaldehyde; Hyperalgesia; Male; Oxi | 2015 |
The effects of levetiracetam, sumatriptan, and caffeine in a rat model of trigeminal pain: interactions in 2-component combinations.
Topics: Analgesics; Animals; Behavior, Animal; Caffeine; Disease Models, Animal; Dose-Response Relationship, | 2015 |
The role of nicotinic acetylcholine and opioid systems of the ventral orbital cortex in modulation of formalin-induced orofacial pain in rats.
Topics: Analgesics, Opioid; Animals; Bridged Bicyclo Compounds, Heterocyclic; Drug Therapy, Combination; Fac | 2015 |
Synergistic interaction between tapentadol and flupirtine in the rat orafacial formalin test.
Topics: Aminopyridines; Analgesics; Animals; Dose-Response Relationship, Drug; Drug Synergism; Facial Pain; | 2015 |
Role of the thalamic submedius nucleus histamine H1 and H 2 and opioid receptors in modulation of formalin-induced orofacial pain in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Histamine Agonists; | 2015 |
Diverse effects of Brilliant Blue G administration in models of trigeminal activation in the rat.
Topics: Analgesics, Non-Narcotic; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Drug Eva | 2015 |
Clonidine Reduces Nociceptive Responses in Mouse Orofacial Formalin Model: Potentiation by Sigma-1 Receptor Antagonist BD1047 without Impaired Motor Coordination.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Animals; Blood Pressure; Clonidine; Disease Models | 2015 |
Acid-sensing ion channels in trigeminal ganglion neurons innervating the orofacial region contribute to orofacial inflammatory pain.
Topics: Acid Sensing Ion Channel Blockers; Acid Sensing Ion Channels; Animals; Electrophysiological Phenomen | 2016 |
Coactivation of μ- and κ-Opioid Receptors May Mediate the Protective Effect of Testosterone on the Development of Temporomandibular Joint Nociception in Male Rats.
Topics: Animals; Brain Stem; Facial Pain; Formaldehyde; Male; Naloxone; Naltrexone; Narcotic Antagonists; No | 2016 |
Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-α-bisabolol, its main compound, in mice.
Topics: Analgesics; Animals; Anti-Infective Agents; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Res | 2016 |
The role of trigeminal nucleus caudalis orexin 1 receptor in orofacial pain-induced anxiety in rat.
Topics: Animals; Anxiety; Benzoxazoles; Capsaicin; Disease Models, Animal; Exploratory Behavior; Facial Pain | 2016 |
A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study.
Topics: Analgesics; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Facial Pain; Form | 2017 |
(-)-α-Bisabolol reduces orofacial nociceptive behavior in rodents.
Topics: Acrolein; Administration, Oral; Administration, Topical; Analgesics; Animals; Behavior, Animal; Bind | 2017 |
The Antinociceptive Effect of a Tapentadol-Ketorolac Combination in a Mouse Model of Trigeminal Pain is Mediated by Opioid Receptors and ATP-Sensitive K
Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Facial Pain; | 2017 |
Effects of intra-hippocampal microinjection of vitamin B
Topics: Analgesics; Animals; CA1 Region, Hippocampal; Catheters, Indwelling; Disease Models, Animal; Dose-Re | 2017 |
Nociceptive and inflammatory responses induced by formalin in the orofacial region of rats: effect of anti-TNFalpha strategies.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Behavior, Animal; Capillar | 2009 |
Evaluation of antihyperalgesic effect of curcumin on formalin-induced orofacial pain in rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Curcumin; Diclofenac; Dose-Response Re | 2009 |
Substance P expression in the distal cerebrospinal fluid-contacting neurons and spinal trigeminal nucleus in formalin-induced the orofacial inflammatory pain in rats.
Topics: Animals; Facial Pain; Formaldehyde; Immunohistochemistry; Inflammation; Injections, Subcutaneous; Ma | 2009 |
Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents, Non-St | 2010 |
Eating is a protected behavior even in the face of persistent pain in male rats.
Topics: Animals; Disease Models, Animal; Disinfectants; Dose-Response Relationship, Drug; Facial Pain; Feedi | 2009 |
Down-regulation of K+ -Cl- co-transporter 2 in mouse medullary dorsal horn contributes to the formalin-induced inflammatory orofacial pain.
Topics: Animals; Down-Regulation; Facial Pain; Formaldehyde; Hyperalgesia; K Cl- Cotransporters; Male; Mice; | 2009 |
Effect of microinjection of histamine into the dorsal hippocampus on the orofacial formalin-induced pain in rats.
Topics: Analgesics; Animals; Behavior, Animal; Facial Pain; Formaldehyde; Hippocampus; Histamine; Histamine | 2010 |
Intracisternal administration of NR2 antagonists attenuates facial formalin-induced nociceptive behavior in rats.
Topics: Animals; Behavior, Animal; Cisterna Magna; Disease Models, Animal; Excitatory Amino Acid Antagonists | 2010 |
Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability.
Topics: Action Potentials; Acyclic Monoterpenes; Aldehydes; Analgesics; Animals; Capsaicin; Facial Pain; For | 2010 |
The orofacial formalin test in mice revisited--effects of formalin concentration, age, morphine and analysis method.
Topics: Age Factors; Analgesics, Opioid; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Irritan | 2011 |
Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Hippocampus; Histami | 2011 |
Synergism between dexketoprofen and meloxicam in an orofacial formalin test was not modified by opioid antagonists.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship | 2011 |
Synergism between fentanyl and tramadol in tonic inflammatory pain: the orofacial formalin test.
Topics: Analgesics; Animals; Drug Synergism; Facial Pain; Fentanyl; Formaldehyde; Inflammation; Male; Mice; | 2012 |
[Effect of orofacial inflammatory pain on p38 mitogen-activated protein kinase activation in trigeminal caudal nucleus of rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Enzyme Inhibitors; Facial Pain; | 2012 |
Comparison of analgesic effects of single versus repeated injection of botulinum toxin in orofacial formalin test in rats.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Drug Administration Schedule; | 2013 |
Orofacial antinociceptive effect and antioxidant properties of the hydroethanol extract of Hyptis fruticosa salmz ex Benth.
Topics: Analgesics; Animals; Antioxidants; Behavior, Animal; Capsaicin; Ethanol; Facial Pain; Formaldehyde; | 2013 |
Contribution of neurokinin 1 receptors in the cutaneous orofacial inflammatory pain.
Topics: Animals; Behavior, Animal; Cisterna Magna; Dose-Response Relationship, Drug; Facial Pain; Formaldehy | 2003 |
Involvement of bradykinin, cytokines, sympathetic amines and prostaglandins in formalin-induced orofacial nociception in rats.
Topics: Animals; Arachidonic Acids; Atenolol; Behavior, Animal; Biogenic Amines; Bradykinin; Bradykinin B1 R | 2004 |
Synergistic antinociceptive effect of amitriptyline and morphine in the rat orofacial formalin test.
Topics: Amitriptyline; Analgesics, Opioid; Animals; Antidepressive Agents; Dose-Response Relationship, Drug; | 2004 |
Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats.
Topics: Animals; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dose-Response Relationship, D | 2004 |
Blockade of peripheral 5HT3 receptor attenuates the formalin-induced nocifensive behavior in persistent temporomandibular joint inflammation of rat.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Facial Pain | 2004 |
Antinociceptive effect of Er:YAG laser irradiation in the orofacial formalin test.
Topics: Animals; Facial Pain; Formaldehyde; Low-Level Light Therapy; Male; Pain Measurement; Rats; Rats, Wis | 2005 |
Intracisternal administration of chemokines facilitated formalin-induced behavioral responses in the orofacial area of freely moving rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Chemokine CCL2; Chemokine CCL5; Chemokines; Dose-Re | 2005 |
Central serotonin 3 receptors play an important role in the modulation of nociceptive neural activity of trigeminal subnucleus caudalis and nocifensive orofacial behavior in rats with persistent temporomandibular joint inflammation.
Topics: Action Potentials; Administration, Topical; Analysis of Variance; Animals; Behavior, Animal; Disease | 2005 |
The orofacial formalin test in the mouse: a behavioral model for studying physiology and modulation of trigeminal nociception.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Capsaicin; Disease Models, Anima | 2006 |
Effects of traditional "Juci" (contralateral acupuncture) on orofacial nociceptive behavior in the rat.
Topics: Acupuncture Therapy; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Disinf | 2007 |
Activation of central 5HT2A receptors reduces the craniofacial nociception of rats.
Topics: Action Potentials; Amphetamines; Animals; Behavior, Animal; Disease Models, Animal; Drug Interaction | 2007 |
Antinoceptive effect of triterpenoid alpha,beta-amyrin in rats on orofacial pain induced by formalin and capsaicin.
Topics: Analgesics; Animals; Burseraceae; Capsaicin; Dose-Response Relationship, Drug; Drug Administration S | 2008 |
The NMDA antagonist Memantine blocks pain behavior in a rat model of formalin-induced facial pain.
Topics: Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Facial Pain; Formaldehyde; | 1993 |
The peripheral antinociceptive effect of morphine in a rat model of facial pain.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Facial Pain; Formaldehyde; Grooming; | 1996 |
Behavioral assessment of facial pain in rats: face grooming patterns after painful and non-painful sensory disturbances in the territory of the rat's infraorbital nerve.
Topics: Animals; Behavior, Animal; Facial Pain; Formaldehyde; Functional Laterality; Grooming; Male; Orbit; | 1998 |
Effects of lesions in the trigeminal oralis and caudalis subnuclei on different orofacial nociceptive responses in the rat.
Topics: Animals; Dental Pulp; Electric Stimulation; Facial Pain; Formaldehyde; Injections, Subcutaneous; Mal | 1998 |
Antihyperalgesic activity of epibatidine in the formalin model of facial pain.
Topics: Analgesics, Non-Narcotic; Animals; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relationsh | 2001 |
Intrathecal midazolam versus intrathecal morphine in orofacial nociception: an experimental study in rats.
Topics: Animals; Facial Pain; Formaldehyde; Injections, Spinal; Male; Midazolam; Morphine; Mouth; Nociceptor | 1992 |
Patient in Sargenti case gets new trial.
Topics: Alabama; Drug Combinations; Eugenol; Extravasation of Diagnostic and Therapeutic Materials; Facial P | 1992 |
Application of the formalin test to the study of orofacial pain in the rat.
Topics: Acetaminophen; Animals; Aspirin; Facial Pain; Formaldehyde; Injections, Intraperitoneal; Injections, | 1989 |