formaldehyde has been researched along with Disease Models, Animal in 575 studies
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of this study was to establish animal model of acute rhinosinusitis (ARS), and determine whether ethyl pyruvate (EP) attenuate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in ARS animals." | 8.02 | Ethyl pyruvate ameliorate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in rats with acute rhinosinusitis. ( He, G; Liang, X; Shen, Y; Tan, G; Zhang, X, 2021) |
| " To evaluate the analgesic effects of AC, 4 different pain models including hot plate assay, acetic acid writhing assay, formalin and CFA induced pain models were adopted in this study." | 8.02 | Comparison of analgesic activities of aconitine in different mice pain models. ( Chen, J; Deng, J; Feng, Q; Han, J; Huang, Q; Leung, EL; Liu, Z; Lu, L; Qi, X; Wang, D; Wang, Y; Zhang, Y, 2021) |
| "Cannabidiol, the major non-psychoactive constituent of Cannabis, has attracted much attention as a therapeutic agent for intractable chronic pain in many conditions." | 8.02 | Cannabidiol microinjection into the nucleus accumbens attenuated nociceptive behaviors in an animal model of tonic pain. ( Haghparast, A; Keyhanfar, F; Rashvand, M; Razavi, Y; Sharifi, A, 2021) |
| "Sixty-six Wistar rats were allocated into five groups: the first group (six rats) was treated with the vehicle only, without induction of paw edema and granulomatous inflammation, and served as a negative control; the second group (12 rats) was allocated into two subgroups and treated with the vehicle only, with induction of paw edema and granulomatous inflammation, and served as a positive control; the third group (36 rats) was allocated into six subgroups and treated with different doses of aliskiren (15, 30, and 60 mg/kg) in both models; the fourth group (12 rats) was treated with dexamethasone (1 mg/kg) in both models of inflammation." | 7.96 | The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation. ( Ahmed, ZA; Aziz, TA; Kareem, AA; Othman, HH, 2020) |
| "Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain." | 7.91 | Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain. ( Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E, 2019) |
| "Diisononyl phthalate (DINP) and formaldehyde both are associated with asthma and allergies." | 7.88 | Exposure to formaldehyde and diisononyl phthalate exacerbate neuroinflammation through NF-κB activation in a mouse asthma model. ( Chen, M; Deng, T; Duan, J; Gong, S; Kang, J; Li, B; Liu, H; Qin, W; Yang, X; Yu, W, 2018) |
| "Epidemiological evidence suggests that formaldehyde (FA) exposure may influence the prevalence and severity of allergic asthma." | 7.85 | Differential effects of formaldehyde exposure on airway inflammation and bronchial hyperresponsiveness in BALB/c and C57BL/6 mice. ( Bao, Y; He, Y; Hua, L; Li, L, 2017) |
| "3mg/kg) or carvedilol (10mg/kg) was administrated orally 1h before histamine injection into animals of a histamine-induced paw edema model and orally daily for 11days into animals of a formaldehyde-induced arthritis model." | 7.85 | Carvedilol can attenuate histamine-induced paw edema and formaldehyde-induced arthritis in rats without risk of gastric irritation. ( Kamel, MM; Labib, DA; Osman, AS, 2017) |
| "In this study, we investigated the protection effect of Vitamin E (Vit E) on formaldehyde (FA) exposure during pregnancy induced apoptosis of cardiomyocytes, and used an HL-1 cell line to confirmed the findings in vivo." | 7.85 | Vitamin E Reversed Apoptosis of Cardiomyocytes Induced by Exposure to High Dose Formaldehyde During Mice Pregnancy. ( Dou, Y; Gong, B; Jiang, Z; Song, M; Song, X; Tian, Y; Wu, D, 2017) |
| " In this study, the possible modulatory role of cobalt (II) chloride (CoCl2) on low level Pb exposure on tail immersion test and formalin induced pain was investigated." | 7.85 | Effect of Low Dose Lead (Pb) Administration on Tail Immersion Test and Formalin-induced Pain in Wistar Rats: Possible Modulatory Role of Cobalt (II) Chloride. ( Muhammed, H; Suleiman, I; Umar, AH, 2017) |
| "This study aimed to investigate the involvement of opioid receptors in the systemic and peripheral antinociceptive activities of montelukast in different animal models of pain." | 7.83 | Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain. ( Alboghobeish, S; Ghorbanzadeh, B; Mansouri, MT; Sahraei, H, 2016) |
| "To observe the effect of formaldehyde inhalation on the allergic rhinitis mice model." | 7.81 | [Effect of formaldehyde inhalation on allergic rhinitis in mice]. ( Xiang, R; Xu, Y, 2015) |
| "This study aimed to investigate whether LSD1 in metastasized MRMT-1 breast cancer cells in bone marrows participated in the production of endogenous formaldehyde in bone cancer pain rats." | 7.79 | Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats. ( Cai, J; Chen, W; Li, H; Li, ZH; Liao, FF; Liu, FY; Liu, J; Luo, HJ; Luo, WH; Tang, JM; Tang, Y; Tong, ZQ; Wan, Y, 2013) |
| " Opioid coadministration had a synergistic effect in the acute tonic pain (acetic acid writhing test), acute phasic pain (tail flick test) and inflammatory pain (orofacial formalin test)." | 7.79 | Systemic synergism between codeine and morphine in three pain models in mice. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Zepeda, RJ, 2013) |
| "Formaldehyde might be a key risk factor for the rise in asthma cases." | 7.79 | Role of transient receptor potential ion channels and evoked levels of neuropeptides in a formaldehyde-induced model of asthma in BALB/c mice. ( Chen, R; Lai, K; Li, J; Li, L; Liu, X; Ma, P; Wu, Y; Yang, X; Yao, H; Ye, X; You, H; Yuan, Y, 2013) |
| "To study the effects of neonatal pain and morphine treatment on the developing brain in a neonatal rat model." | 7.79 | Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain. ( Bendix, I; Boos, V; Dührsen, L; Dzietko, M; Felderhoff-Mueser, U; Genz, K; Sifringer, M; Simons, SH; Tibboel, D, 2013) |
| "Tolerance to morphine analgesia following repeated administration disturbs the continuation of opioid therapy for severe pain." | 7.78 | Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms. ( Fukazawa, Y; Iwai, S; Kiguchi, N; Kishioka, S; Kobayashi, Y; Saika, F; Ueno, K; Yamamoto, C, 2012) |
| "Our previous study showed that tumor tissue-derived formaldehyde at low concentrations plays an important role in bone cancer pain through activating transient receptor potential vanilloid subfamily member 1 (TRPV1)." | 7.78 | Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone cancer pain. ( Han, Y; Li, Y; Liu, FY; Liu, J; Meng, XL; Wan, Y; Xiao, X; Xing, GG, 2012) |
| " In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model." | 7.78 | Antinociceptive effects of intrathecal landiolol injection in a rat formalin pain model. ( Itano, Y; Kaku, R; Kanzaki, H; Matsuoka, Y; Mizobuchi, S; Morita, K; Nishie, H; Obata, N; Ouchida, M; Taniguchi, A; Tomotsuka, N, 2012) |
| "Endothelin-1 (ET-1) has been suggested to be involved in different types of pain due to its neuromodulatory nature." | 7.78 | Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection. ( Chen, AY; Chen, SM; Cheung, CW; Chung, SK; Hung, VK; Tai, LW, 2012) |
| "The present study explored the interaction between histaminergic and opioidergic systems at the level of the hippocampus in modulation of orofacial pain by intra-hippocampal microinjections of histamine, pyrilamine (an antagonist of histamine H(1) receptors), ranitidine (an antagonist of histamine H(2) receptors), morphine (an opioid receptor agonist) and naloxone (an opioid receptor antagonist) in separate and combined treatments." | 7.77 | Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats. ( Erfanparast, A; Farshid, AA; Khalilzadeh, E; Tamaddonfard, E, 2011) |
| " Formaldehyde-inactivated whole-virus vaccines derived from EV71 clinical isolates and a mouse-adapted virus (MAV) were tested in a mouse model of EV71 encephalomyelitis." | 7.76 | Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease. ( Cardosa, MJ; Devi, S; Ong, KC; Wong, KT, 2010) |
| "Z-360, a novel cholecystokinin(2) (CCK(2)) receptor antagonist, has been developed as a therapeutic drug for pancreatic cancer and showed pain relief action in phase Ib/IIa clinical trial." | 7.76 | Pharmacological evaluation of analgesic effects of the cholecystokinin2 receptor antagonist Z-360 in mouse models of formalin- and cancer-induced pain. ( Eta, R; Hamano, H; Hori, Y; Horii, T; Kawabata, Y; Kuraishi, Y; Orikawa, Y; Ozaki, T; Seto, K; Takei, M; Yoshii, K; Yoshinaga, K, 2010) |
| "The inhibitory transmitters GABA and glycine play an important role in modulating pain transmission, both in normal and in pathological situations." | 7.76 | Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. ( Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç, 2010) |
| "One of the possible sites of action of the analgesic effect of morphine is the Nucleus Raphe Magnus, as morphine injected into this structure induces analgesia in transient pain models." | 7.74 | Analgesia induced by morphine microinjected into the nucleus raphe magnus: effects on tonic pain. ( Dallel, R; Dualé, C; Sierralta, F, 2007) |
| "Intrathecally administered edaravone, a free radical scavenger, had analgesic effects on inflammatory-induced acute and facilitated pain but not on acute thermal pain, without any behavioural side-effects." | 7.73 | Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats. ( Nishiyama, T; Ogawa, M, 2005) |
| "Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia." | 7.73 | Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity. ( Lee, IH; Lee, IO, 2005) |
| "We studied the effects of the high-efficacy 5-hydroxytryptamine1A (5-HT1A) receptor agonist, F 13640 on both formalin-induced spinal cord c-Fos protein expression and pain behaviours in the rat." | 7.73 | Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: a c-Fos study. ( Aliaga, M; Besson, JM; Buritova, J; Colpaert, F; Larrue, S, 2005) |
| "It has been demonstrated that spinal microglial activation is involved in formalin-induced pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral hypersensitivity in neuropathic pain models." | 7.73 | Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat. ( Cho, IH; Choi, SY; Chung, YM; Jung, SJ; Kim, D; Kim, JS; Lee, H; Lee, SJ; Li, HY; Oh, SB; Park, CK; Park, K; Park, SH; Piao, ZG, 2006) |
| "The present study evaluates the possible role of dihydropyridine calcium channel antagonist nimodipine on diclofenac analgesia in formalin-induced facial pain model in rats." | 7.72 | Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats. ( Hota, D; Pandhi, P, 2004) |
| "Intrathecal administration of propofol had analgesic effects on inflammation-induced acute and facilitated pain but not on thermally-induced acute pain." | 7.72 | Intrathecal propofol has analgesic effects on inflammation-induced pain in rats. ( Hanaoka, K; Matsukawa, T; Nishiyama, T, 2004) |
| "We have previously shown (Gastroenterology, 101 (1991) 1211-1219), that substance P (SP) decreases early in the colon muscle layer after induction of colitis in rabbits." | 7.69 | Substance P gene expression in acute experimental colitis. ( Adler, G; Eysselein, VE; Reinshagen, M, 1995) |
| "Pain associated-anxiety induced by formalin, which resulted in a significant delay in the development of tolerance to morphine antinociception, failed to prevent the development of physical dependence as evidenced by naloxone challenge." | 7.69 | Morphine dependence with or without tolerance in formalin-treated mice: further evidence for the dissociation. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "To assess the anti-inflammatory action of lexipafant (BB-882), a platelet activating factor antagonist, in an animal model of acute colitis." | 7.69 | Lexipafant (BB-882), a platelet activating factor receptor antagonist, ameliorates mucosal inflammation in an animal model of colitis. ( Dijkhuizen, S; Grool, TA; Hommes, DW; Meenan, J; ten Kate, FJ; Tytgat, GN; van Deventer, SJ; Whittaker, M; Wood, M, 1996) |
| "In humans, orofacial pain has a high prevalence and is often difficult to treat." | 5.48 | Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels. ( Dožić, BS; Dožić, IS; Karadžić, BV; Milovanović, AP; Prostran, MŠ; Savić Vujović, KR; Srebro, DP; Vučković, SM, 2018) |
| "treatment with oxyntomodulin during the second, but not the first phase." | 5.48 | Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models. ( Hong, JW; Jang, SP; Lee, HJ; Lee, JR; Park, SH; Suh, HW, 2018) |
| "Luteolin is a naturally occurring flavonoid with diverse pharmacological properties such as anti-inflammatory, antioxidant and anticancer." | 5.46 | Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice. ( Abdollahzadeh, M; Golmakani, E; Hashemzaei, M; Iranshahi, M; Rezaee, R; Tabrizian, K, 2017) |
| "Drug effects on formalin-induced mechanical allodynia were evaluated for comparison." | 5.43 | Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats. ( Leitl, MD; Negus, SS, 2016) |
| "Dehydrocorydaline (DHC) is an alkaloidal component isolated from Rhizoma corydalis." | 5.43 | Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. ( Chu, SS; Gu, XP; Li, L; Ma, ZL; Sun, Q; Yin, ZY, 2016) |
| "Atopic dermatitis is a complex disease of heterogeneous pathogenesis, in particular, genetic predisposition, environmental triggers, and their interactions." | 5.43 | Formaldehyde-Induced Aggravation of Pruritus and Dermatitis Is Associated with the Elevated Expression of Th1 Cytokines in a Rat Model of Atopic Dermatitis. ( Back, SK; Han, RT; Kim, HJ; Kim, HY; Lee, H; Lee, J; Na, HS, 2016) |
| "Formaldehyde (FA) is an environmental and occupational pollutant that induces programming mechanisms on the acquired immune host defense in offspring when exposed during the prenatal period." | 5.42 | Formaldehyde inhalation during pregnancy abolishes the development of acute innate inflammation in offspring. ( Barioni, ÉD; Correa-Costa, M; Drewes, CC; Lino-dos-Santos-Franco, A; Miranda da Silva, C; Poliselli Farsky, SH; Saraiva Câmara, NO; Silva Ibrahim, B; Tavares-de-Lima, W, 2015) |
| "Formaldehyde (FA) is an environmental and occupational pollutant, and its toxic effects on the immune system have been shown." | 5.40 | Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring. ( Câmara, NO; Correa-Costa, M; Farsky, SH; Gimenes Júnior, JA; Lino-dos-Santos-Franco, A; Maiellaro, M; Tavares-de-Lima, W; Vitoretti, LB, 2014) |
| "Pain is a complex experience composed of sensory and affective components." | 5.39 | Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats. ( Hara, T; Ide, S; Kaneda, K; Koseki, K; Maruyama, C; Minami, M; Naka, T; Ohno, A; Tamano, R; Yoshioka, M, 2013) |
| "NA-3,4-DCM, dosed systemically (intraperitoneally or per os), was capable of interfering with the development of mechanical hypernociception induced by intraplantar injection of carrageenan and complete Freund adjuvant in mice." | 5.36 | N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system. ( Antonialli, CS; Corrêa, R; da Silva, GF; de Campos-Buzzi, F; Filho, VC; Quintão, NL, 2010) |
| "Lacosamide is a functionalized amino acid which was initially synthesized as an antiepileptic drug." | 5.33 | Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain. ( Krause, E; Selve, N; Stöhr, T, 2006) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 5.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| "The United States Environmental Protection Agency (EPA) recently proposed a hypothetical mode of action (MOA) to explain how inhaled formaldehyde (FA) might induce leukemia, lymphoma and a variety of other lymphohematopoietic (LHP) malignancies in occupationally exposed workers." | 4.84 | Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies? ( Golden, R; Natelson, E; Pyatt, D, 2008) |
| " The aim of this study was to establish animal model of acute rhinosinusitis (ARS), and determine whether ethyl pyruvate (EP) attenuate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in ARS animals." | 4.02 | Ethyl pyruvate ameliorate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in rats with acute rhinosinusitis. ( He, G; Liang, X; Shen, Y; Tan, G; Zhang, X, 2021) |
| " To evaluate the analgesic effects of AC, 4 different pain models including hot plate assay, acetic acid writhing assay, formalin and CFA induced pain models were adopted in this study." | 4.02 | Comparison of analgesic activities of aconitine in different mice pain models. ( Chen, J; Deng, J; Feng, Q; Han, J; Huang, Q; Leung, EL; Liu, Z; Lu, L; Qi, X; Wang, D; Wang, Y; Zhang, Y, 2021) |
| " The acetylcholinesterase inhibitor (ACHEI); neostigmine, is known clinically for its analgesic effect in the perioperative phases proving high efficacy; besides possessing anti-inflammatory properties controlling immune cells and cytokine level." | 4.02 | The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation. ( Abdel-Bary, A; El-Tahan, RA; Gowayed, MA, 2021) |
| "Cannabidiol, the major non-psychoactive constituent of Cannabis, has attracted much attention as a therapeutic agent for intractable chronic pain in many conditions." | 4.02 | Cannabidiol microinjection into the nucleus accumbens attenuated nociceptive behaviors in an animal model of tonic pain. ( Haghparast, A; Keyhanfar, F; Rashvand, M; Razavi, Y; Sharifi, A, 2021) |
| "In this study, four monomers derived from Corydalis yanhusuo (tetrahydropalmatine, corydaline, protopine, dehydrocorydaline) were tested in vivo, using the formalin-induced pain model to determine their analgesic properties." | 4.02 | Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels. ( Li, W; Liu, Y; Lv, K; Su, Y; Sun, J; Teng, Y; Xu, Y; Yang, L; Zhang, J; Zhang, S; Zhao, M, 2021) |
| "Sixty-six Wistar rats were allocated into five groups: the first group (six rats) was treated with the vehicle only, without induction of paw edema and granulomatous inflammation, and served as a negative control; the second group (12 rats) was allocated into two subgroups and treated with the vehicle only, with induction of paw edema and granulomatous inflammation, and served as a positive control; the third group (36 rats) was allocated into six subgroups and treated with different doses of aliskiren (15, 30, and 60 mg/kg) in both models; the fourth group (12 rats) was treated with dexamethasone (1 mg/kg) in both models of inflammation." | 3.96 | The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation. ( Ahmed, ZA; Aziz, TA; Kareem, AA; Othman, HH, 2020) |
| " The plant extract at doses of 50, 100 and 150 mg/kg was tested for anti-inflammatory activity against carrageenan and egg albumin induced paw edema in mice and analgesic activity was appraised against acetic acid induced writhing and formalin induced paw licking in mice models." | 3.96 | Evaluation of anti-inflammatory and analgesic activities of aqueous methanolic extract of Ranunculus muricatus in albino mice. ( Alamgeer, -; Asif, H; Hasan, UH; Irfan, HM; Nasreen, P; Sharif, A; Uttra, AM; Younis, W, 2020) |
| " platensis on different types of pain and inflammation in comparison to diclofenac sodium." | 3.96 | Effects of Spirulina platensis on pain and inflammation in long Evans rats. ( Akhter, S; Ali, T; Nipa, NS; Rafiq, K, 2020) |
| " Nociceptive response induced by formaldehyde and mechanical allodynia induced by chronic constriction injury (CCI) of the sciatic nerve or intraplantar (ipl) injection of complete Freund's adjuvant (CFA) were used as experimental models of pain." | 3.91 | The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain. ( Alves, RJ; Araújo, DP; Batista, CRA; Brito, AMS; Canhestro, WG; Coelho, MM; Coura, GME; de Fátima, Â; Dutra, MMGB; Godin, AM; Machado, RR; Matsui, TC; Melo, ISF, 2019) |
| "Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain." | 3.91 | Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain. ( Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E, 2019) |
| "Diisononyl phthalate (DINP) and formaldehyde both are associated with asthma and allergies." | 3.88 | Exposure to formaldehyde and diisononyl phthalate exacerbate neuroinflammation through NF-κB activation in a mouse asthma model. ( Chen, M; Deng, T; Duan, J; Gong, S; Kang, J; Li, B; Liu, H; Qin, W; Yang, X; Yu, W, 2018) |
| " All synthesized new compounds along with compound III as a parent compound and Celecoxib as a reference, were assessed for their antiinflammatory activity both in-vivo and in-vitro using the formalin-induced hind paw edema method and inhibition of albumin denaturation and Red Blood Cells (RBCs) membrane stabilization, respectively." | 3.88 | Synthesis, In-vivo and In-vitro Anti-inflammatory Evaluation of some Novel Coumarin Derivatives. ( Al-Wabli, R; El-Haggar, R; Fouad, M, 2018) |
| " Isovaline is a novel prototype analgesic that produces peripheral antinociception in several pain models with little or no effect on the central nervous system." | 3.85 | Variations of isovaline structure related to activity in the formalin foot assay in mice. ( Asiri, YI; Fung, T; MacLeod, BA; Puil, E; Schwarz, SKW; Wall, R, 2017) |
| "Epidemiological evidence suggests that formaldehyde (FA) exposure may influence the prevalence and severity of allergic asthma." | 3.85 | Differential effects of formaldehyde exposure on airway inflammation and bronchial hyperresponsiveness in BALB/c and C57BL/6 mice. ( Bao, Y; He, Y; Hua, L; Li, L, 2017) |
| "3mg/kg) or carvedilol (10mg/kg) was administrated orally 1h before histamine injection into animals of a histamine-induced paw edema model and orally daily for 11days into animals of a formaldehyde-induced arthritis model." | 3.85 | Carvedilol can attenuate histamine-induced paw edema and formaldehyde-induced arthritis in rats without risk of gastric irritation. ( Kamel, MM; Labib, DA; Osman, AS, 2017) |
| "In this study, we investigated the protection effect of Vitamin E (Vit E) on formaldehyde (FA) exposure during pregnancy induced apoptosis of cardiomyocytes, and used an HL-1 cell line to confirmed the findings in vivo." | 3.85 | Vitamin E Reversed Apoptosis of Cardiomyocytes Induced by Exposure to High Dose Formaldehyde During Mice Pregnancy. ( Dou, Y; Gong, B; Jiang, Z; Song, M; Song, X; Tian, Y; Wu, D, 2017) |
| "The purposes of this study were to evaluate the anti-nociceptive effect of oral and topical administration of (-)-α-bisabolol (BISA) in rodent models of formalin- or cinnamaldehyde-induced orofacial pain and to explore the inhibitory mechanisms involved." | 3.85 | (-)-α-Bisabolol reduces orofacial nociceptive behavior in rodents. ( Campos, AR; da Costa, FN; de Vasconcellos Abdon, AP; Duailibe, MA; Melo, LT; Pessoa, LM; Vieira-Neto, AE, 2017) |
| "The extract was assessed for antinociceptive activity using chemical and heat induced pain models such as hot plate, tail immersion, acetic acid-induced writhing, formalin, glutamate, and cinnamaldehyde test models in mice at the doses of 100, 200, and 400 mg/kg (p." | 3.85 | Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice. ( Khan, MF; Khatun, A; Mannan, MA, 2017) |
| " In this study, the possible modulatory role of cobalt (II) chloride (CoCl2) on low level Pb exposure on tail immersion test and formalin induced pain was investigated." | 3.85 | Effect of Low Dose Lead (Pb) Administration on Tail Immersion Test and Formalin-induced Pain in Wistar Rats: Possible Modulatory Role of Cobalt (II) Chloride. ( Muhammed, H; Suleiman, I; Umar, AH, 2017) |
| "05) suppressed topical ear edema, systemic paw edema, global edematous response to formaldehyde arthritis and granuloma tissue growth." | 3.83 | Extracts of Leptadenia hastata Leaf, a Famine Food and Traditional Remedy for Furuncles, Suppress Inflammation in Murine Models. ( Akah, PA; Ezea, SC; Ezike, AC; Okoli, CO; Ufere, IK, 2016) |
| "This study aimed to investigate the involvement of opioid receptors in the systemic and peripheral antinociceptive activities of montelukast in different animal models of pain." | 3.83 | Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain. ( Alboghobeish, S; Ghorbanzadeh, B; Mansouri, MT; Sahraei, H, 2016) |
| " Analgesic activity using acetic acid induced writhing and formalin test in mice, anti-inflammatory activity using carrageenan induced paw oedema and acetic acid-induced vascular permeability in mice, and antipyretic activity using Brewer's yeast induced pyrexia in rats were evaluated at 100mg/kg, 200mg/kg, and 400mg/kg doses of the extract." | 3.83 | Anti-oxidant, anti-inflammatory, analgesic and antipyretic activities of grapevine leaf extract (Vitis vinifera) in mice and identification of its active constituents by LC-MS/MS analyses. ( Aouey, B; Bouaziz, M; Fetoui, H; Samet, AM; Simmonds, MSJ, 2016) |
| " Xylene-induced ear edema, carrageenan-induced paw edema and acetic acid-induced vascular permeability test were used to investigate the anti-inflammatory activities of GL in mice." | 3.81 | Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice. ( Li, YX; Ma, L; Niu, Y; Niu, YT; Shi, GJ; Sun, T; Wang, HL; Wu, J; Yu, JQ; Zheng, J, 2015) |
| "To observe the effect of formaldehyde inhalation on the allergic rhinitis mice model." | 3.81 | [Effect of formaldehyde inhalation on allergic rhinitis in mice]. ( Xiang, R; Xu, Y, 2015) |
| " In the present study, we demonstrate prevention of BTX-A antinociceptive effect on formalin-induced inflammatory pain and partial sciatic nerve transection-induced mechanical allodynia by GABA-A antagonist bicuculline, thus suggesting association of the GABA-A receptors and antinociceptive action of BTX-A." | 3.80 | Association of antinociceptive action of botulinum toxin type A with GABA-A receptor. ( Bach-Rojecky, L; Drinovac, V; Lacković, Z, 2014) |
| " In order to evaluate the anti-inflammatory effect of these flavonoids, capsaicin-induced ear oedema was carried out." | 3.80 | Antinociceptive and anti-inflammatory effects of flavonoids PMT1 and PMT2 isolated from Piper montealegreanum Yuncker (Piperaceae) in mice. ( Alexandre-Moreira, MS; Alves, Hda S; Campesatto, EA; Cavalcante-Silva, LH; Chaves, MC; de Queiroz, AC; Dias, Tde L; Melo, GM; Santos, Mda S, 2014) |
| " Third, formalin-induced depression of ICSS was reversed by morphine doses that did not significantly alter ICSS in saline-treated rats, suggesting that formalin effects on ICSS can be interpreted as an example of pain-related and analgesic-reversible depression of behavior." | 3.80 | Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats. ( Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Potter, DN; Rice, KC, 2014) |
| "The cerebrospinal fluid concentration of free neostigmine reached 5 μg/ml five hours after injection and remained constant until the end of the experiments." | 3.80 | Epidural administration of neostigmine-loaded nanofibers provides extended analgesia in rats. ( Hassanpour-Ezatti, M; Yosefifard, M, 2014) |
| "This study aimed to investigate whether LSD1 in metastasized MRMT-1 breast cancer cells in bone marrows participated in the production of endogenous formaldehyde in bone cancer pain rats." | 3.79 | Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats. ( Cai, J; Chen, W; Li, H; Li, ZH; Liao, FF; Liu, FY; Liu, J; Luo, HJ; Luo, WH; Tang, JM; Tang, Y; Tong, ZQ; Wan, Y, 2013) |
| " Opioid coadministration had a synergistic effect in the acute tonic pain (acetic acid writhing test), acute phasic pain (tail flick test) and inflammatory pain (orofacial formalin test)." | 3.79 | Systemic synergism between codeine and morphine in three pain models in mice. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Zepeda, RJ, 2013) |
| "Ipsilateral, but not contralateral, pre-treatment (in μg/paw) with sumatriptan (10-300), methysergide (1-30) or dihydroergotamine (1-30) significantly prevented flinching behavior (at 1h) as well as secondary allodynia and hyperalgesia (at day 6) induced by formalin." | 3.79 | Role of 5-HT₁B/₁D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats. ( Argüelles, CF; Godínez-Chaparro, B; Granados-Soto, V; López-Santillán, FJ; Villalón, CM, 2013) |
| "Formaldehyde might be a key risk factor for the rise in asthma cases." | 3.79 | Role of transient receptor potential ion channels and evoked levels of neuropeptides in a formaldehyde-induced model of asthma in BALB/c mice. ( Chen, R; Lai, K; Li, J; Li, L; Liu, X; Ma, P; Wu, Y; Yang, X; Yao, H; Ye, X; You, H; Yuan, Y, 2013) |
| "To study the effects of neonatal pain and morphine treatment on the developing brain in a neonatal rat model." | 3.79 | Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain. ( Bendix, I; Boos, V; Dührsen, L; Dzietko, M; Felderhoff-Mueser, U; Genz, K; Sifringer, M; Simons, SH; Tibboel, D, 2013) |
| " The analgesic activity was examined against oxytocin-induced dysmenorrhea in mice." | 3.78 | Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii. ( Chen, T; Duan, JA; Gu, W; Hua, Y; Jiang, H; Su, S; Tang, Y; Wang, Y; Zhou, W, 2012) |
| "Tolerance to morphine analgesia following repeated administration disturbs the continuation of opioid therapy for severe pain." | 3.78 | Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms. ( Fukazawa, Y; Iwai, S; Kiguchi, N; Kishioka, S; Kobayashi, Y; Saika, F; Ueno, K; Yamamoto, C, 2012) |
| "Our previous study showed that tumor tissue-derived formaldehyde at low concentrations plays an important role in bone cancer pain through activating transient receptor potential vanilloid subfamily member 1 (TRPV1)." | 3.78 | Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone cancer pain. ( Han, Y; Li, Y; Liu, FY; Liu, J; Meng, XL; Wan, Y; Xiao, X; Xing, GG, 2012) |
| " In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model." | 3.78 | Antinociceptive effects of intrathecal landiolol injection in a rat formalin pain model. ( Itano, Y; Kaku, R; Kanzaki, H; Matsuoka, Y; Mizobuchi, S; Morita, K; Nishie, H; Obata, N; Ouchida, M; Taniguchi, A; Tomotsuka, N, 2012) |
| "Endothelin-1 (ET-1) has been suggested to be involved in different types of pain due to its neuromodulatory nature." | 3.78 | Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection. ( Chen, AY; Chen, SM; Cheung, CW; Chung, SK; Hung, VK; Tai, LW, 2012) |
| " We have investigated the behavioural effects of carvacrol in animal models of pain, such as acetic acid-induced abdominal constriction, formalin and hot-plate tests in mice." | 3.78 | Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice. ( Cavalcante Melo, FH; Citó, Mdo C; de Sousa, DP; de Sousa, FC; de Vasconcelos, SM; Fernandes, ML; Rios, ER; Rocha, NF, 2012) |
| "To evaluate the antinociceptive effect of Emilia sonchifolia hydroethanolic extract (EsHE) administered by oral route, peripheral (acetic acid-induced abdominal writhing and formalin), spinal (tail flick) and supra-spinal (hot plate) behavioral models of acute pain were used." | 3.77 | Antinociceptive effect of extract of Emilia sonchifolia in mice. ( Couto, VM; Dias, DF; Dos Santos, MH; Giusti-Paiva, A; Nascimento, CG; Soncini, R; Vilela, FC, 2011) |
| " Effects of intrathecal glutamate transporter activator (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline and inhibitors (DL-threo-β-benzyloxyaspartate [TBOA], dihydrokainate, and DL-threo-β-hydroxyaspartate), or TBOA plus group III metabotropic glutamate receptor antagonist (RS)-α-methylserine-O-phosphate, on formalin- and CFA-induced inflammatory pain were examined." | 3.77 | Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant. ( Guan, X; Lu, W; Petralia, RS; Rothstein, JD; Tao, YX; Yaster, M, 2011) |
| "The present study explored the interaction between histaminergic and opioidergic systems at the level of the hippocampus in modulation of orofacial pain by intra-hippocampal microinjections of histamine, pyrilamine (an antagonist of histamine H(1) receptors), ranitidine (an antagonist of histamine H(2) receptors), morphine (an opioid receptor agonist) and naloxone (an opioid receptor antagonist) in separate and combined treatments." | 3.77 | Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats. ( Erfanparast, A; Farshid, AA; Khalilzadeh, E; Tamaddonfard, E, 2011) |
| "The aim of the present study was to investigate the preemptive analgesic effects of intraperitoneally administrated midazolam and diclofenac, before acute and inflammatory induced pain in rat model." | 3.77 | Preemptive analgesic effects of midazolam and diclofenac in rat model. ( Hasani, A; Jakupi, M; Soljakova, M; Ustalar-Ozgen, S, 2011) |
| " Treatment of male ICR mice with ETL significantly inhibited the numbers of acetic acid-induced writhing response and the formalin-induced pain in the late phase." | 3.77 | Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola. ( Chi, CS; Deng, JS; Huang, GJ; Huang, SS; Lin, TH; Shie, PH, 2011) |
| "The antinociceptive effect of MCO was evaluated using several experimental pain models, including thermal nociception methods, such as the tail immersion and the hotplate tests, as well as chemical nociception induced by intraperitoneal acetic acid and subplantar formalin administration in mice." | 3.77 | Antinociceptive and hypnotic properties of Celastrus orbiculatus. ( Cha, DS; Jeon, H; Park, HJ, 2011) |
| " In an inflammatory pain model, Compound 5 suppressed the capsaicin-induced flinching behavior in a dose-dependent manner." | 3.77 | Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia. ( Akasaka, Y; Hatta, A; Inoue, H; Sakai, A; Suzuki, H; Takasu, K; Tsukahara, M, 2011) |
| "To develop a behavioral model in mice that is capable of mimicking some distinctive symptoms of human posttraumatic trigeminal neuropathic pain such as spontaneous pain, cold allodynia, and chemical÷inflammatory hyperalgesia, and to use this model to investigate the antinociceptive effects of clomipramine and tramadol, two drugs used for the treatment of neuropathic pain." | 3.77 | Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice. ( Alvarez, P; Brun, A; Constandil, L; Correa, A; Hernández, A; Labertrandie, A; Lopez, J; Pelissier, T, 2011) |
| " Formaldehyde-inactivated whole-virus vaccines derived from EV71 clinical isolates and a mouse-adapted virus (MAV) were tested in a mouse model of EV71 encephalomyelitis." | 3.76 | Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease. ( Cardosa, MJ; Devi, S; Ong, KC; Wong, KT, 2010) |
| "Z-360, a novel cholecystokinin(2) (CCK(2)) receptor antagonist, has been developed as a therapeutic drug for pancreatic cancer and showed pain relief action in phase Ib/IIa clinical trial." | 3.76 | Pharmacological evaluation of analgesic effects of the cholecystokinin2 receptor antagonist Z-360 in mouse models of formalin- and cancer-induced pain. ( Eta, R; Hamano, H; Hori, Y; Horii, T; Kawabata, Y; Kuraishi, Y; Orikawa, Y; Ozaki, T; Seto, K; Takei, M; Yoshii, K; Yoshinaga, K, 2010) |
| " The blueberry extract produced a significant decrease in constrictions induced by acetic acid and caused graded inhibition of the second phase of formalin-induced pain." | 3.76 | Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models. ( Barros, DM; de Castro, MR; de Souza, MM; Dickel, OE; Guterres, L; Henriques, AT; Ramirez, MR, 2010) |
| " The objective of this study was to investigate the antinociceptive effect of the ethanolic extract from this species' stem bark (EtOH), its fractions of partition (hexane-HEX, ethyl acetate-AcOEt, aqueous-AQ) and lupeol (a triterpene obtained from HEX) in models of acute pain." | 3.76 | Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents. ( Almeida, FR; Chaves, MH; Costa, DA; Figueiredo, KA; Lopes, LS; Marques, RB; Pereira, SS, 2010) |
| "Maternal methamphetamine (MA) abuse during pregnancy has been proved to induce various impacts on the development of infant and child." | 3.76 | Prenatal exposure to methamphetamine alters the mechanical withdrawal threshold and tonic hyperalgesia in the offspring. ( Chen, JY; Chen, KB; Kuo, CT; Tao, PL; Wen, YR; Yeh, GC, 2010) |
| "These results indicate that KOR plays an important role in the inhibition of repeated morphine-induced cPKC up-regulation under chronic pain condition." | 3.76 | Involvement of kappa opioid receptors in the formalin-induced inhibition of analgesic tolerance to morphine via suppression of conventional protein kinase C activation. ( Fujita-Hamabe, W; Harada, S; Nagae, R; Nakamoto, K; Nawa, A; Tokuyama, S, 2010) |
| "The inhibitory transmitters GABA and glycine play an important role in modulating pain transmission, both in normal and in pathological situations." | 3.76 | Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. ( Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç, 2010) |
| "Our data suggest that activation of spinal or dorsal root ganglion HCN channels or both is not involved in formalin-induced pain, and intrathecal gabapentin does not act as an HCN channel activator to achieve its antinociceptive effect in the formalin test." | 3.75 | Intrathecal gabapentin does not act as a hyperpolarization-activated cyclic nucleotide-gated channel activator in the rat formalin test. ( Chen, CC; Cheng, JK; Huang, YJ; Lin, CF; Lin, CS; Tsaur, ML, 2009) |
| "6% of 10 ml) induced pain and the effects were also compared to aspirin, morphine and naloxone while formalin induced pain (0." | 3.75 | Antinociceptive activity of Amaranthus spinosus in experimental animals. ( Amresh, G; Rao, CV; Singh, S; Zeashan, H, 2009) |
| "The present study examined the antinociceptive effects of (O-methyl) N-benzoyl-tyramine (riparin I, ripI) isolated from the unripe fruit of Aniba riparia in chemical and thermal behavioral models of pain, such as acetic acid-induced abdominal writhing, formalin, and hot-plate tests in mice." | 3.75 | Antinociceptive effects of (O-methyl)-N-benzoyl tyramine (riparin I) from Aniba riparia (Nees) Mez (Lauraceae) in mice. ( Amaral, JF; Araújo, FL; Barbosa-Filho, JM; de Sousa, FC; Gutierrez, SJ; Leite, CP; Melo, CT; Moura, BA; Rocha, NF; Vasconcelos, SM; Viana, GS, 2009) |
| "Formaldehyde (FA) is a common indoor air pollutant that can cause asthma in people experiencing long-term exposure." | 3.75 | Irritant and adjuvant effects of gaseous formaldehyde on the ovalbumin-induced hyperresponsiveness and inflammation in a rat model. ( Li, B; Liu, D; Qiao, Y; Sigsgaard, T; Yan, Y; Yang, G; Yang, J; Yang, X; Yao, H, 2009) |
| ") dose-dependently inhibited nociceptive behavior in the acetic acid-induced pain test." | 3.74 | Quercetin: further investigation of its antinociceptive properties and mechanisms of action. ( de Souza, MM; Filho, AW; Filho, VC; Olinger, L, 2008) |
| " The glucan was tested for its effects on the acetic acid-induced writhing reaction in mice, a typical model for quantifying inflammatory pain." | 3.74 | Anti-inflammatory and analgesic properties in a rodent model of a (1-->3),(1-->6)-linked beta-glucan isolated from Pleurotus pulmonarius. ( Baggio, CH; Carbonero, ER; Freitas, CS; Gorin, PA; Iacomini, M; Marcon, R; Olsen, LM; Santos, AR; Smiderle, FR, 2008) |
| "In this study, the effect of (S)-3,4-dicarboxyphenylglycine (DCPG), a selective mGlu8 receptor agonist, has been investigated in inflammatory and neuropathic pain models in order to elucidate the role of mGlu8 receptor in modulating pain perception." | 3.74 | Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. ( de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Scafuro, MA; Vita, D, 2007) |
| "One of the possible sites of action of the analgesic effect of morphine is the Nucleus Raphe Magnus, as morphine injected into this structure induces analgesia in transient pain models." | 3.74 | Analgesia induced by morphine microinjected into the nucleus raphe magnus: effects on tonic pain. ( Dallel, R; Dualé, C; Sierralta, F, 2007) |
| "The dose-response relation of S-methylisothiourea, rofecoxib, mefenamic acid, and their combination was studied in the late phase of formalin-induced pain in mice over the time spent in licking the hindpaw after formalin injection." | 3.74 | The interaction between inhibitors of nitric oxide synthase and cyclooxygenase in formalin-induced pain in mice: an isobolographic study. ( Bhat, AS; Krishna, V; Kumar, D; Prakash, VR; Tandan, SK, 2008) |
| " Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously)." | 3.74 | Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| "Intrathecally administered edaravone, a free radical scavenger, had analgesic effects on inflammatory-induced acute and facilitated pain but not on acute thermal pain, without any behavioural side-effects." | 3.73 | Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats. ( Nishiyama, T; Ogawa, M, 2005) |
| "Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia." | 3.73 | Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity. ( Lee, IH; Lee, IO, 2005) |
| "We studied the effects of the high-efficacy 5-hydroxytryptamine1A (5-HT1A) receptor agonist, F 13640 on both formalin-induced spinal cord c-Fos protein expression and pain behaviours in the rat." | 3.73 | Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: a c-Fos study. ( Aliaga, M; Besson, JM; Buritova, J; Colpaert, F; Larrue, S, 2005) |
| "It has been demonstrated that spinal microglial activation is involved in formalin-induced pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral hypersensitivity in neuropathic pain models." | 3.73 | Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat. ( Cho, IH; Choi, SY; Chung, YM; Jung, SJ; Kim, D; Kim, JS; Lee, H; Lee, SJ; Li, HY; Oh, SB; Park, CK; Park, K; Park, SH; Piao, ZG, 2006) |
| "5% formalin injection into the hind paw, acetic acid administration intraperitoneally or neuropathic pain testing consisting of mechanical allodynia (von Frey filament) and thermal hyperalgesia (Plantar test)." | 3.73 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| "Mesalazine, betamethasone, and misoprostol are the best topical agents for radiation proctitis and formalin has an inflammatory effect and should not be used." | 3.73 | Histopathological comparison of topical therapy modalities for acute radiation proctitis in an experimental rat model. ( Aksoy, M; Asoglu, O; Bilge, H; Kapran, Y; Kiremit-Korkut, N; Korkut, C; Parlak, M, 2006) |
| "The present study evaluates the possible role of dihydropyridine calcium channel antagonist nimodipine on diclofenac analgesia in formalin-induced facial pain model in rats." | 3.72 | Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats. ( Hota, D; Pandhi, P, 2004) |
| "Intrathecal administration of propofol had analgesic effects on inflammation-induced acute and facilitated pain but not on thermally-induced acute pain." | 3.72 | Intrathecal propofol has analgesic effects on inflammation-induced pain in rats. ( Hanaoka, K; Matsukawa, T; Nishiyama, T, 2004) |
| "5, 5 and 10 mg kg (-1)) was investigated and compared with diclofenac sodium (5 mg kg (-1)) using the formalin-, histamine-, and carrageenan-induced paw oedema and cotton pellet granuloma tests." | 3.71 | Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice. ( Büyükokuroğlu, ME, 2002) |
| "Incarvillateine (1), a new monoterpene alkaloid carrying a characteristic cyclobutane ring, has been found to show significant antinociceptive activity in a formalin-induced pain model in mice." | 3.71 | Structure-antinociceptive activity studies of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis. ( Chi, YM; Hashimoto, F; Kinjo, J; Nakamura, M; Nakasugi, Y; Nohara, T; Sakurada, S; Yan, WM; Yonezawa, A; Yoshizawa, T, 2001) |
| "We have previously shown (Gastroenterology, 101 (1991) 1211-1219), that substance P (SP) decreases early in the colon muscle layer after induction of colitis in rabbits." | 3.69 | Substance P gene expression in acute experimental colitis. ( Adler, G; Eysselein, VE; Reinshagen, M, 1995) |
| " In chronic models of formaldehyde and adjuvant arthritis, its anti-arthritic activity was found to be less than that of phenylbutazone (PNB)." | 3.69 | Anti-inflammatory activity of the bark of Hippocratea excelsa. ( Perez, RM; Perez, S; Salazar, M; Zavala, MA, 1995) |
| "Pain associated-anxiety induced by formalin, which resulted in a significant delay in the development of tolerance to morphine antinociception, failed to prevent the development of physical dependence as evidenced by naloxone challenge." | 3.69 | Morphine dependence with or without tolerance in formalin-treated mice: further evidence for the dissociation. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "To assess the anti-inflammatory action of lexipafant (BB-882), a platelet activating factor antagonist, in an animal model of acute colitis." | 3.69 | Lexipafant (BB-882), a platelet activating factor receptor antagonist, ameliorates mucosal inflammation in an animal model of colitis. ( Dijkhuizen, S; Grool, TA; Hommes, DW; Meenan, J; ten Kate, FJ; Tytgat, GN; van Deventer, SJ; Whittaker, M; Wood, M, 1996) |
| "Orally delivered, inactivated whole-cell vaccines are safe methods of inducing local and systemic immunity." | 2.72 | Safety and immunogenicity of an oral, inactivated, whole-cell vaccine for Shigella sonnei: preclinical studies and a Phase I trial. ( Bourgeois, AL; Carpenter, C; Forbes, E; Gomes, G; Jackson, WJ; McKenzie, R; Nabors, GS; Pace, JL; Tian, JH; Van De Verg, LL; Walker, RI; Yang, HH, 2006) |
| "EESE significantly reduced edema, cold allodynia and mechanical hyperalgesia responses induced by CFA." | 1.91 | Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves. ( Arena, AC; Bernal, LPT; Cardoso, CAL; Fraga, TL; Kassuya, CAL; Leitão, MM; Lencina, JDS; Radai, JAS; Silva-Filho, SE, 2023) |
| "Formaldehyde (FA) is a ubiquitous endogenous and environmental metabolite that is thought to exert cytotoxicity through DNA and DNA-protein crosslinking, likely contributing to the onset of the human DNA repair condition Fanconi Anaemia." | 1.72 | Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity. ( Bollini, M; Crossan, GP; Fernández, GA; Kolesnikova, K; Martinefski, MR; Monge, ME; Morellato, AE; Pak, O; Pontel, LB; Reingruber, H; Rieckher, M; Scheidegger, MA; Schumacher, B; Sommer, N; Umansky, C, 2022) |
| "Migraine is a complex neurovascular disorder characterized by recurrent attacks of pain and other associated symptoms." | 1.72 | Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior. ( Demartini, C; Francavilla, M; Greco, R; Tassorelli, C; Zanaboni, AM, 2022) |
| " High dosage (200 μg/mL) of EEVt displayed highly significant inhibitory (p < 0." | 1.62 | The anti-inflammatory and analgesic activities of the ethyl acetate extract of Viburnum taitoense Hayata. ( He, S; Huang, Y; Qiu, L; Wu, X; Xie, J; Xie, Y; Xu, H; Zhang, Q; Zou, L, 2021) |
| "Pain is an unpleasant sensory and emotional experience, often accompanied by the occurrence of a variety of diseases." | 1.62 | Active components of Bupleurum chinense and Angelica biserrata showed analgesic effects in formalin induced pain by acting on Nav1.7. ( Li, W; Liao, X; Liu, Y; Su, Y; Wang, Q; Xu, Y; Yu, Y; Zhang, J; Zhang, S; Zhao, M, 2021) |
| " Dose-response for each NSAIDs were created before and after 5 mg/kg of L-NAME i." | 1.56 | Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R, 2020) |
| "In baclofen treatment group, thermal hyperalgesia and formalin test improved in comparison with morphine tolerance group." | 1.56 | Repeated Administration of Baclofen Modulates TRPV-1 Channel Expression by PKC Pathway in Dorsal Root Ganglia of Spinal Cord in a Morphine Tolerance Model of Rats ( Ashabi, G; Hoseini, M; Karimiyan, SM; Mehrabadi, S; Moradbeygi, K, 2020) |
| "The poncirin (30 mg/kg) treatment considerably inhibited the mechanical hyperalgesia and allodynia as well as thermal hyperalgesia and cold allodynia." | 1.51 | Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice. ( Afridi, R; Khalid, S; Khan, AU; Khan, S; Kim, YS; Rasheed, H; Shal, B; Shehzad, O; Ullah, MZ, 2019) |
| "Last, in the 4T1 model of breast cancer, we demonstrate the utility of our protocol and Ab panels in the quantitation and spatial distribution of immune cells." | 1.51 | Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues. ( Brekken, RA; Burton, N; Dahal, LN; Dominguez, ATA; Ganguly, D; Huang, H; Sorrelle, N; Zhang, Y; Ziemys, A, 2019) |
| "Although the magnitude of the hyperalgesia is dependent on the intensity of the conditioning stimulus, we find that the direction of effect is dependent on the effective test stimulus intensity, with lower-intensity stimuli leading to hyperalgesia and higher-intensity stimuli leading to hypoalgesia." | 1.51 | Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity. ( Austin, JS; Coderre, TJ; Diamond, L; George, N; Macintyre, LC; Martin, LJ; Meluban, L; Mogil, JS; Sotocinal, SG; Tansley, SN, 2019) |
| " But its long-term administration increases the risk of complications of pharmacotherapy." | 1.51 | Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels. ( Beskhmelnitsyna, EA; Kulikov, AL; Peresypkina, AA; Pokrovskii, MV; Varavin, EI, 2019) |
| "miliacea in the treatment of fever with possible anti-nociceptive effects." | 1.51 | Antipyretic and anti-nociceptive effects of methanol extract of leaves of Fimbristylis miliacea in mice model. ( Akter, A; Barek, MA; Basher, MA; Liya, IJ; Roy, R; Sultana, S; Ud Daula, AFMS, 2019) |
| "Formaldehyde is a common agent in our surrounding environment and can adversely affect the male reproductive system." | 1.51 | The effect of hydroethanolic extract of Matricaria chamomilla on the reproductive system of male rats exposed to formaldehyde. ( Abdanipour, A; Afrigan, L; Arianmanesh, M; Ghorbanlou, M; Jafari Anarkooli, I; Sayyar, Z; Sohrabi, D; Yazdinezhad, A, 2019) |
| "In humans, orofacial pain has a high prevalence and is often difficult to treat." | 1.48 | Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels. ( Dožić, BS; Dožić, IS; Karadžić, BV; Milovanović, AP; Prostran, MŠ; Savić Vujović, KR; Srebro, DP; Vučković, SM, 2018) |
| "treatment with oxyntomodulin during the second, but not the first phase." | 1.48 | Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models. ( Hong, JW; Jang, SP; Lee, HJ; Lee, JR; Park, SH; Suh, HW, 2018) |
| "Most drugs used to treat pain and inflammation have potential side effects, which makes it necessary to search for new sources of bioactive molecules." | 1.48 | LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice. ( Alencar Filho, EB; Almeida, JRGDS; Barreiro, EJL; Diniz, TC; Lavor, ÉM; Lima, LM; Lima-Saraiva, SRG; Mendes, RL; Oliveira Júnior, RG; Silva, JC; Silva, MGE; Soares, JMD, 2018) |
| "Formaldehyde (FA) has been implicated in Alzheimer's disease (AD) pathology as an age-related factor and as a protein cross-linker known to aggregate Amyloid-Beta (Aβ) and tau protein in vitro." | 1.48 | Alzheimer's Disease-Like Pathologies and Cognitive Impairments Induced by Formaldehyde in Non-Human Primates. ( He, R; He, X; He, Y; Hu, X; Li, Z; Ma, Y; Rizak, J; Su, T; Wang, Z; Yang, M; Yin, Y; Zhai, R; Zheng, N, 2018) |
| "Coccidioidomycosis is a potentially life-threatening mycosis endemic to the Southwestern USA and some arid regions of Central and South America." | 1.46 | Rational Design of T Lymphocyte Epitope-Based Vaccines Against Coccidioides Infection. ( Hung, CY; Hurtgen, BJ, 2017) |
| "Tauopathies such as Alzheimer's disease (AD) feature progressive intraneuronal deposition of aggregated tau protein." | 1.46 | Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue. ( Braak, H; Del Tredici, K; Diamond, MI; Kaufman, SK; Thomas, TL, 2017) |
| "Sinomenine, which is a main bioactive ingredient in Sinomenium acutum, has been reported to have an analgesic effect in diverse pain animal models." | 1.46 | Sinomenine produces peripheral analgesic effects via inhibition of voltage-gated sodium currents. ( Kang, Y; Kim, HB; Lee, JY; Oh, SB; Won, J; Yoon, SY, 2017) |
| "Atopic dermatitis is chronically relapsing pruritic eczema and prevails around the world especially in developed countries." | 1.46 | Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment. ( Back, SK; Han, RT; Kim, HJ; Kim, HY; Lee, J; Na, HS, 2017) |
| "Muscle pain was induced by intramuscular injection of a diluted formalin solution (2." | 1.46 | Role of thalamic ventral posterolateral nucleus histamine H ( Ghasemi, H; Soltanalinejad, F; Tamaddonfard, E, 2017) |
| "Kynurenic acid (KYNA) has well-established protective properties against glutamatergic neurotransmission, which plays an essential role in the activation and sensitization process during some primary headache disorders." | 1.46 | A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study. ( Bajtai, A; Bohár, Z; Fejes-Szabó, A; Fülöp, F; Laborc, K; László, AM; Mándity, I; Nagy-Grócz, G; Párdutz, Á; Szatmári, I; Szentirmai, M; Vécsei, L; Veres, G; Zádori, D, 2017) |
| "Visceral pain has a greater emotional component than somatic pain." | 1.46 | Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States. ( Baeyens, JM; Cervero, F; Cobos, EJ; Coderre, TJ; Gonzalez-Cano, R; Lehmann, M; Pitcher, MH; Vincent, K, 2017) |
| "Luteolin is a naturally occurring flavonoid with diverse pharmacological properties such as anti-inflammatory, antioxidant and anticancer." | 1.46 | Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice. ( Abdollahzadeh, M; Golmakani, E; Hashemzaei, M; Iranshahi, M; Rezaee, R; Tabrizian, K, 2017) |
| "Drug effects on formalin-induced mechanical allodynia were evaluated for comparison." | 1.43 | Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats. ( Leitl, MD; Negus, SS, 2016) |
| "In vivo, IT LPS evoked tactile allodynia to a greater degree in male than female mice." | 1.43 | Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state. ( Beaton, G; Chigbrow, M; Corr, M; Eddinger, KA; Isseroff, RR; Ravula, SB; Soulika, AM; Tucci, FC; Woller, SA; Yaksh, TL, 2016) |
| "Dehydrocorydaline (DHC) is an alkaloidal component isolated from Rhizoma corydalis." | 1.43 | Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. ( Chu, SS; Gu, XP; Li, L; Ma, ZL; Sun, Q; Yin, ZY, 2016) |
| " Initial pharmacokinetics evaluation indicated an excellent brain exposure following oral dosing in mice, suggesting that further investigation into the use of alkoxyisoxazoles as σ1 ligands for antinociception is warranted." | 1.43 | Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy. ( Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM, 2016) |
| "Cataracts were created through the injection of 0." | 1.43 | Porcine cataract creation using formalin or microwave treatment for an ophthalmology wet lab. ( Arora, S; Damji, KF; Kutzner, M; Machuk, RWA, 2016) |
| "Pain is one of the most challenging and stressful conditions to patients with sickle cell disease (SCD) and their clinicians." | 1.43 | CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice. ( Chen, Y; DeSimone, J; He, Y; Lu, J; Molokie, RE; Tian, X; Wang, ZJ; Wilkie, DJ; Xiao, C; Yang, C, 2016) |
| "Atopic dermatitis is a complex disease of heterogeneous pathogenesis, in particular, genetic predisposition, environmental triggers, and their interactions." | 1.43 | Formaldehyde-Induced Aggravation of Pruritus and Dermatitis Is Associated with the Elevated Expression of Th1 Cytokines in a Rat Model of Atopic Dermatitis. ( Back, SK; Han, RT; Kim, HJ; Kim, HY; Lee, H; Lee, J; Na, HS, 2016) |
| "Probenecid has been widely used in the treatment of gout, but evidence suggests that it may also have antinociceptive effects in different inflammatory and pain conditions." | 1.42 | Effect of probenecid on the pain-related behaviour and morphological markers in orofacial formalin test of the rat. ( Bohár, Z; Fejes-Szabó, A; Nagy-Grócz, G; Párdutz, Á; Pődör, B; Tajti, J; Tar, L; Toldi, J; Vámos, E; Vécsei, L, 2015) |
| " The main objective of the present work was to enhance the dissolution of MLX and thus its bioavailability by the aid of additives." | 1.42 | Utilization of spray drying technique for improvement of dissolution and anti-inflammatory effect of Meloxicam. ( Alomrani, A; Badran, M; Shazly, G; Zoheir, K, 2015) |
| "In the pleurisy model, induced by carrageenan, treatment with SA inhibited important events involved in inflammatory responses, namely leukocyte influx, plasma leakage, and increased inflammatory mediators (TNF-α, IL-1β, and chemokine CXCL1), in the pleural exudate." | 1.42 | Antinociceptive and anti-inflammatory activity of the siaresinolic acid, a triterpene isolated from the leaves of Sabicea grisea Cham. & Schltdl. var. grisea. ( Barreto, E; Conserva, LM; de Araújo, AF; de Oliveira, AM; de Souza Ferro, JN; Lyra Lemos, RP, 2015) |
| "Levetiracetam is an antiepileptic drug with analgesic efficacy shown in pain models and small clinical trials." | 1.42 | The effects of levetiracetam, sumatriptan, and caffeine in a rat model of trigeminal pain: interactions in 2-component combinations. ( Micov, AM; Pecikoza, UB; Popović, BV; Stepanović-Petrović, RM; Tomić, MA, 2015) |
| "In paclitaxel-treated mice, they did not attenuate heat hyperalgesia but N-(3-aminopropyl)-2-{[(3-methylphenyl)methyl]oxy}-N-(2-thienylmethyl) benzamide hydrochloride salt (AMTB), a TRPM8 antagonist, reduced cold hyperalgesia and tactile allodynia by 31% (P<0." | 1.42 | Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice. ( Filipek, B; Sałat, K, 2015) |
| "Formaldehyde is a common environmental contaminant that causes oxidative DNA damage in cells by increasing the production of reactive oxygen species." | 1.42 | Therapeutic role of curcumin in oxidative DNA damage caused by formaldehyde. ( Aksoy, A; Cenesiz, S; Ciftci, G; Ertekin, A; Guvenc, D; Nisbet, C; Sogut, MU; Yarim, GF, 2015) |
| "Formaldehyde (FA) is an environmental and occupational pollutant that induces programming mechanisms on the acquired immune host defense in offspring when exposed during the prenatal period." | 1.42 | Formaldehyde inhalation during pregnancy abolishes the development of acute innate inflammation in offspring. ( Barioni, ÉD; Correa-Costa, M; Drewes, CC; Lino-dos-Santos-Franco, A; Miranda da Silva, C; Poliselli Farsky, SH; Saraiva Câmara, NO; Silva Ibrahim, B; Tavares-de-Lima, W, 2015) |
| "However, orofacial heat and cold hyperalgesia, induced by carrageenan injected into the upper lip (50 µg/50 μl), was abolished by previous intraganglionar RTX treatment." | 1.40 | Intraganglionar resiniferatoxin prevents orofacial inflammatory and neuropathic hyperalgesia. ( Chichorro, JG; Cruz, LS; Kopruszinski, CM, 2014) |
| "Formaldehyde (FA) is an environmental and occupational pollutant, and its toxic effects on the immune system have been shown." | 1.40 | Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring. ( Câmara, NO; Correa-Costa, M; Farsky, SH; Gimenes Júnior, JA; Lino-dos-Santos-Franco, A; Maiellaro, M; Tavares-de-Lima, W; Vitoretti, LB, 2014) |
| "Pain is a complex experience that made up of sensory, emotional and cognitive dimensions, and the emotional factors have an important influence on intensity of pain perception." | 1.40 | Intra-periaqueductal gray infusion of zeta inhibitory peptide attenuates pain-conditioned place avoidance in rats. ( Huang, Y; Lei, W; Lu, B; Sun, J; Xiao, C; Yao, J; Zhang, H, 2014) |
| "2K1C hypertension was induced in 6-week-old Wistar Hannover rats (n = 6) that were sacrificed 23 weeks later and compared with age-matched sham-operated controls (n = 6)." | 1.40 | Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney, one-clip hypertensive rats. ( Berven, FS; Dahl, TD; Finne, K; Leh, S; Reed, RK; Skogstrand, T; Tenstad, O; Vethe, H; Vikse, BE, 2014) |
| "Peripheral nerve injury can result in neuropathic pain, a chronic condition of unclear cause often poorly responsive to current treatments." | 1.40 | Upregulation of neuregulin-1 reverses signs of neuropathic pain in rats. ( Chen, X; Dai, D; Lu, Y; Wang, G; Yuan, L; Zhang, A; Zhang, P, 2014) |
| "Pain is a complex experience composed of sensory and affective components." | 1.39 | Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats. ( Hara, T; Ide, S; Kaneda, K; Koseki, K; Maruyama, C; Minami, M; Naka, T; Ohno, A; Tamano, R; Yoshioka, M, 2013) |
| " The new fluorinated inhibitor showed higher analgesic activity and bioavailability compared to thiorphan and C20 when administered by both intravenous and intrathecal injections." | 1.39 | NESS002ie: a new fluorinated thiol endopeptidase inhibitor with antinociceptive activity in an animal model of persistent pain. ( Lazzari, P; Olimpieri, F; Pinna, GA; Reali, R; Tambaro, S; Volonterio, A; Zanda, M, 2013) |
| "Treatment with naloxone, L-arginine and glibenclamide reversed the effect of LPEF in glutamate test." | 1.39 | Antinociceptive effect of Lecythis pisonis Camb. (Lecythidaceae) in models of acute pain in mice. ( Almeida, FR; Brandão, MS; Chaves, MH; Ferreira, EL; Lima, DF; Oliveira, JP; Pereira, SS, 2013) |
| "Formaldehyde (FA) has been known to be associated with development of asthma (AS) and atopic dermatitis (AD)." | 1.39 | Aggravation of atopic dermatitis-like symptoms by consecutive low concentration of formaldehyde exposure in NC/Nga mice. ( Jeong, MS; Kim, JY; Park, KY; Seo, SJ, 2013) |
| " Experiments showed that administration of extract (25, 50 and 100 mg kg(-1)) could induced analgesia in a dose-response manner in both phases of formalin test." | 1.38 | Effects of Papaver rhoeas (L.) extract on formalin-induced pain and inflammation in mice. ( Delfan, B; Esfandiari, B; Ghahramani, M; Jafari, F; Mojabi, N; Najafi-Abedi, A; Rahmani, B; Ranjbaran, M; Saeed-Abadi, S; Sahraei, H, 2012) |
| "We evaluated the modulatory role of the groundwater contaminant arsenic on the pharmacodynamic responses of the nonsteroidal analgesic-antipyretic drug ketoprofen and the major pro-inflammatory mediators linked to the mechanism of ketoprofen's therapeutic effects." | 1.38 | Subacute arsenic exposure through drinking water reduces the pharmacodynamic effects of ketoprofen in male rats. ( Ahmad, W; Chanderashekara, HH; Prawez, S; Sankar, P; Sarkar, SN; Tandan, SK, 2012) |
| "Morphine sulfate was used as reference analgesic agent." | 1.38 | Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents. ( Bum, EN; Dawe, A; De Waard, M; Dimo, T; Dzeufiet, PD; Nguimbou, RM; Sidiki, N; Taïwe, GS; Talla, E, 2012) |
| "crassifolius for the treatment of pain and inflammation." | 1.38 | Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract. ( Fang, F; Wang, G; Yang, L; Yu, L; Zhao, J, 2012) |
| "Sick Sinus Syndrome is a common and refractory arrhythmia, needing further study in which setting up a credible sinus node damage model is important." | 1.38 | Comparative study between original and traditional method in establishing a chronic sinus node damage model in rabbit. ( Bao, MJ; Li, HB; Liu, RX; Wang, NN; Wang, YL; Xu, LY, 2012) |
| "Formaldehyde level was analyzed by high-performance liquid chromatography (with fluorescence detection) in human urine from dementia patients (n=141), patients with hypertension (n=33) or diabetes (n=16) and healthy individuals (n=38), autopsy hippocampus samples from Alzheimer's disease (AD) patients and brains of three types of AD animal model: namely, senescence accelerated mice (SAMP8), APP-transgenic mice and APP/PS1-transgenic mice." | 1.37 | Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia. ( He, R; Li, F; Li, H; Lu, J; Luo, H; Luo, W; Tong, Z; Wan, Y; Wang, W; Zhang, J; Zhou, J, 2011) |
| "Pain was induced by formalin injection into the hindpaw." | 1.37 | Synergistic interaction between intrathecal ginsenosides and morphine on formalin-induced nociception in rats. ( Choi, JI; Kim, CM; Kim, KS; Kim, WM; Kim, YO; Lee, HG; Yoon, MH, 2011) |
| "Dexketoprofen was more potent in phase I (19." | 1.37 | Synergism between dexketoprofen and meloxicam in an orofacial formalin test was not modified by opioid antagonists. ( Gonzalez, C; Miranda, HF; Noriega, V; Prieto, JC; Zegpi, C, 2011) |
| "Diazepam effects were blocked by flumazenil." | 1.37 | Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord. ( Cardenas, R; Quintero, L; Suarez-Roca, H, 2011) |
| " The inhibition of oedema formation increased with increasing dosage from 25 to 100mg/kg." | 1.37 | Analgesic effects and anti-inflammatory properties of the crude methanolic extract of Schwenckia americana Linn (Solanaceae). ( Abdullahi, N; Adebisi, I; Chika, A; Jimoh, AO; Umar, MT, 2011) |
| "Evaluation of pain is a critical issue in human pathologies but also in animal experimentation." | 1.37 | Poincaré plot descriptors of heart rate variability as markers of persistent pain expression in freely moving rats. ( Charlet, A; Poisbeau, P; Rodeau, JL, 2011) |
| "This experimental model of lathyrism is appropriate for investigation of the lysyl oxidase inhibitors effect on extracellular matrix." | 1.37 | [Altered collagene characteristics and lysyl oxidase activity in lathyrism]. ( Dmytrenko, MP; Dzvonkevych, ND; Krysiuk, IP; Petrun', LM; Popova, NM; Shandrenko, SH; Volodina, TT, 2011) |
| "Rheumatic heart disease is the most severe complication of rheumatic fever." | 1.36 | An animal model of chronic rheumatic valvulitis induced by formalin-killed streptococci. ( Feng, Z; Gu, J; Huang, H; Huang, J; Mei, K; Su, Z; Xie, X; Yu, B; Zhou, H, 2010) |
| "NA-3,4-DCM, dosed systemically (intraperitoneally or per os), was capable of interfering with the development of mechanical hypernociception induced by intraplantar injection of carrageenan and complete Freund adjuvant in mice." | 1.36 | N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system. ( Antonialli, CS; Corrêa, R; da Silva, GF; de Campos-Buzzi, F; Filho, VC; Quintão, NL, 2010) |
| "OB rats exhibited mechanical allodynia (von Frey test) but not thermal hyperalgesia (hot plate and tail-flick tests) when compared to sham-operated counterparts." | 1.36 | Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions. ( Burke, NN; Calpin, P; Finn, DP; Hayes, E; Kerr, DM; Moriarty, O; Roche, M, 2010) |
| "Myricetin was also not able to increase the sleeping time induced by pentobarbital, which further indicated that the analgesic effect of myricetin was unrelated to sedation." | 1.35 | Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves. ( Cao, YL; Tong, Y; Wang, SJ; Yang, Y; Zhou, XM, 2009) |
| "It also produced thermal allodynia in response to cold (paw acetone test: 200% increase of allodynia score during week 3-5) and heat (42 degrees C tail immersion test: 15% decrease of withdrawal threshold, from week 2 onward)." | 1.35 | Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies. ( Bardin, L; Depoortère, R; Malfetes, N; Newman-Tancredi, A, 2009) |
| "The status of neuropathic pain alters the responsiveness to formalin injection in rats." | 1.34 | Altered response to formalin by L5 spinal nerve ligation in rats: a behavioral and molecular study. ( Itano, Y; Kaku, R; Kobayashi, H; Matsuoka, Y; Mizobuchi, S; Morita, K; Sato, T; Yokoyama, M, 2007) |
| "Pompe disease (glycogenosis type II) is a rare lysosomal disorder caused by a mutational deficiency of acid alpha-glucosidase (GAA)." | 1.34 | Optimized preservation of CNS morphology for the identification of glycogen in the Pompe mouse model. ( Griffiths, D; Johnson, J; Ryan, S; Shihabuddin, LS; Taksir, TV; Thurberg, BL, 2007) |
| "Lacosamide is a functionalized amino acid which was initially synthesized as an antiepileptic drug." | 1.33 | Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain. ( Krause, E; Selve, N; Stöhr, T, 2006) |
| "IL-1beta-induced hyperalgesia was blocked by pretreatment with IL-1 receptor antagonist." | 1.33 | Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats. ( Ahn, DK; Bae, YC; Chae, JM; Choi, HS; Kwon, OW; Kyung, HM; Park, HS; Youn, DH, 2005) |
| "Thermal hyperalgesia (drop of noxious heat threshold) and mechanical hyperalgesia induced by a mild heat injury (51 degrees C, 15s) was smaller in KO mice suggesting a pronociceptive role for TRPV1 receptor in burn injury." | 1.33 | Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice. ( Almási, R; Bölcskei, K; Elekes, K; Helyes, Z; Németh, J; Pethő, G; Pintér, E; Sándor, K; Szabó, Á; Szolcsányi, J, 2005) |
| "The degree of allodynia was most marked following 10 min of irradiation." | 1.32 | Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice. ( Berge, OG; Brodin, E; Flood, K; Gustafsson, H; Olgart, L; Stiller, CO, 2003) |
| "However, they attenuated hyperalgesia in several nociceptive models associated with spinal sensitization including direct spinal activation (intrathecal substance P) and peripheral tissue inflammation (intraplantar formalin or carrageenan)." | 1.32 | Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing. ( Calcutt, NA; Campana, WM; Catalano, R; Feng, Y; Freshwater, JD; Marsala, M; Protter, AA; Scott, B; Svensson, CI; Westerlund, A; Yaksh, TL, 2003) |
| "Preterm infants undergoing untreated, repeated painful procedures as part of their early experience are more likely to behave differently to pain as they mature than infants who were born at term and did not experience excessive exogenous pain." | 1.32 | The effects of exposure to repeated minor pain during the neonatal period on formalin pain behaviour and thermal withdrawal latencies. ( Johnston, CC; Walker, CD, 2003) |
| " Repeated intraperitoneal injections were, therefore, chosen as the dosing regimen." | 1.32 | Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. ( Geisslinger, G; Gühring, H; Kunz, S; Michaelis, M; Niederberger, E; Ritzeler, O; Schmidt, R; Tegeder, I, 2004) |
| ") significantly inhibited phenylquinone-evoked writhing movements in mice, but within this dose range no clear dose-response correlation was found." | 1.32 | Analgesic effect of TT-232, a heptapeptide somatostatin analogue, in acute pain models of the rat and the mouse and in streptozotocin-induced diabetic mechanical allodynia. ( Almási, R; Bölcskei, K; Börzsei, R; Elekes, K; Helyes, Z; Kéri, G; Petho, G; Pintér, E; Szabó, A; Szolcsányi, J; Szuts, T, 2004) |
| "In addition, formalin-induced secondary hyperalgesia was locally prevented by pre-but not post-celecoxib treatment." | 1.32 | Prevention by celecoxib of secondary hyperalgesia induced by formalin in rats. ( Avila, MN; da Motta, PG; Duarte, ID; Francischi, JN; Tatsuo, MA; Veiga, AP, 2004) |
| "The cataract was induced using 0." | 1.31 | Formalin-induced cataract in goat eyes as a surgical training model for phacoemulsification. ( Chandra, P; Rai, H; Sudan, R; Titiyal, JS, 2002) |
| "Formaldehyde was regarded as the strongest allergen in man and also had the lowest EC3 value, 0." | 1.31 | Human potency predictions for aldehydes using the local lymph node assay. ( Basketter, DA; Dearman, RJ; Gerberick, GF; Kimber, I; Ryan, CA; Warbrick, EV; White, IR; Wright, ZM, 2001) |
| "In addition, murine listeriosis is a widely used model for studying the molecular pathogenesis of an intracellular pathogen, and the regulation of protective cellular immunity." | 1.31 | Passive immunization with convalescent serum, or oral immunization with formalin-killed organisms, does not protect mice against gastrointestinal challenge with Listeria monocytogenes. ( Czuprynski, CJ; Miller, DC, 2002) |
| "Pretreatment with morphine (2 mg/kg) attenuated, in a naloxone-reversible manner, the nociceptive behaviour observed following intradental application of capsaicin." | 1.31 | Nociceptive behaviour induced by dental application of irritants to rat incisors: a new model for tooth inflammatory pain. ( Chidiac, JJ; Hawwa, NN; Jabbur, SJ; Jurjus, AR; Massaad, CA; Rifai, K; Saadé, NE, 2002) |
| "The development of cardiac hypertrophy was studied under condition of experimental renal hypertension on the rat." | 1.31 | [Significance of nitric oxide function in development of cardiac hypertrophy under condition of experimental renal hypertension]. ( Eliseeva, EV; Motavkin, PA; Tishchenko, OV, 2002) |
| "However, the HE did not affect the hyperalgesia induced by carrageenan or PGE2." | 1.30 | Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae). ( Calixto, JB; Campos, MM; Cechinel Filho, V; Mendes, GL; Santos, AR; Tratsk, KS; Yunes, RA, 1998) |
| "Pentobarbital pretreatment failed to suppress FLI." | 1.30 | Pre- versus postinjury effects of intravenous GABAergic anesthetics on formalin-induced Fos immunoreactivity in the rat spinal cord. ( Coderre, TJ; Gilron, I; Quirion, R, 1999) |
| " These risk assessments have typically been based on tumor data in F344 rats exposed chronically to formaldehyde by inhalation and used the inhaled concentration as a measure of dose and the linearized multistage model (LMS) for dose-response characterization." | 1.29 | An approach to mechanism-based cancer risk assessment for formaldehyde. ( Andersen, ME; Conolly, RB, 1993) |
| "When ampicillin was administered again 1 h after formalin was given, no bacteria were recovered from lungs 6 h later." | 1.29 | Streptococcus pneumoniae in the nasal cavity of mice causes lower respiratory tract infection after airway obstruction. ( Hiroe, K; Iizawa, Y; Kitamoto, N; Nakao, M, 1996) |
| "Sclerosing cholangitis has been reported after surgical treatment of hydatid disease of the liver and has been hypothetically attributed to the caustic effect of the parasiticide solution injected into the cyst and diffusing into the biliary tree through a cystic-biliary fistula." | 1.28 | Sclerosing cholangitis induced by formaldehyde solution injected into the biliary tree of rats. ( Belghiti, J; Benhamou, JP; Houry, S; Huguier, M; Languille, O; Msika, S, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 38 (6.61) | 18.7374 |
| 1990's | 43 (7.48) | 18.2507 |
| 2000's | 151 (26.26) | 29.6817 |
| 2010's | 295 (51.30) | 24.3611 |
| 2020's | 48 (8.35) | 2.80 |
| Authors | Studies |
|---|---|
| Monastyrskyi, A | 1 |
| Brockmeyer, F | 1 |
| LaCrue, AN | 1 |
| Zhao, Y | 2 |
| Maher, SP | 1 |
| Maignan, JR | 1 |
| Padin-Irizarry, V | 1 |
| Sakhno, YI | 1 |
| Parvatkar, PT | 1 |
| Asakawa, AH | 1 |
| Huang, L | 2 |
| Casandra, D | 1 |
| Mashkouri, S | 1 |
| Kyle, DE | 1 |
| Manetsch, R | 1 |
| Snyder, JM | 1 |
| Radaelli, E | 1 |
| Goeken, A | 1 |
| Businga, T | 1 |
| Boyden, AW | 1 |
| Karandikar, NJ | 1 |
| Gibson-Corley, KN | 1 |
| Hossaini, M | 2 |
| Duraku, LS | 2 |
| Kohli, SK | 1 |
| Jongen, JL | 1 |
| Holstege, JC | 2 |
| Bayram-Weston, Z | 1 |
| Olsen, E | 1 |
| Harrison, DJ | 1 |
| Dunnett, SB | 1 |
| Brooks, SP | 1 |
| Stahl, M | 1 |
| Graef, FA | 1 |
| Vallance, BA | 1 |
| Kasukurthi, R | 1 |
| Brenner, MJ | 1 |
| Moore, AM | 1 |
| Moradzadeh, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Study Evaluating the Gastroprotective Effect of Carvedilol in Patients With Ischemic Heart Disease on Aspirin Therapy[NCT05553717] | 66 participants (Anticipated) | Interventional | 2022-10-31 | Not yet recruiting | |||
| Oxidative Stress and Surgical Recovery[NCT04732000] | Phase 2 | 21 participants (Actual) | Interventional | 2021-07-01 | Active, not recruiting | ||
| STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic Pancreatitis[NCT05603702] | Phase 1 | 24 participants (Anticipated) | Interventional | 2023-03-17 | Recruiting | ||
| A Multicenter, Randomized, Open-label, Controlled Trial to Assess Effectiveness and Safety of Rhea Health Tone® as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia[NCT04627519] | 85 participants (Actual) | Interventional | 2020-12-09 | Active, not recruiting | |||
| Itch Relieving Effect of Botox: a Study in Healthy Subjects[NCT02639052] | Phase 1/Phase 2 | 35 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| Intravesical Botulinum Toxin A Injection in Treatment of Interstitial Cystitis Refractory to Conventional Treatment - A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial[NCT01969773] | Phase 2 | 60 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Intraoral Administration of Onabotulinum Toxin A for Continuous Neuropathic Pain: a Single Subject Experimental Design[NCT03848143] | Phase 2 | 10 participants (Anticipated) | Interventional | 2019-09-11 | Recruiting | ||
| A 12-week Prospective, Double-blinded, Randomized, Multicenter Study of Low Dose and Medium Dose Botulinum Toxin Type A (Dysport® ) Injection for Migraine Prophylaxis.[NCT00258609] | Phase 3 | 128 participants | Interventional | 2003-02-28 | Completed | ||
| Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy[NCT03571334] | Phase 2 | 40 participants (Anticipated) | Interventional | 2020-07-08 | Recruiting | ||
| The Effect of Aminophylline on Preventing Acute Kidney Injury in Pediatric Patients Undergoing Open Heart Surgery[NCT03897335] | Phase 3 | 80 participants (Anticipated) | Interventional | 2019-02-07 | Recruiting | ||
| Iontophoresis Effects on Senses[NCT02487914] | Phase 2/Phase 3 | 30 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors[NCT05684367] | 24 participants (Anticipated) | Interventional | 2023-11-29 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A secondary endpoint is to see if Botox has a relieving effect on heat pain using a pain visual analog scale (VAS) intensity scale as an outcome measure. The pain VAS intensity scale ranges from a minimum of 0 (no pain - best) to a maximum of 10 (maximum pain - worst). Participants will rate pain intensity after pain is induced with a heat thermode. (NCT02639052)
Timeframe: Baseline, 1 week, 1 month, 3 months
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline | 1 Week | 1 Month | 3 Months | All Visits | |
| Botox | 3.6 | 3.7 | 3.7 | 4.1 | 3.8 |
| Saline | 3.7 | 3.7 | 4.1 | 4.3 | 4.0 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: 1 Month from Baseline
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 Month (Visit 3), 0 seconds | 1 Month (Visit 3), 30 seconds | 1 Month (Visit 3), 60 seconds | 1 Month (Visit 3), 90 seconds | 1 Month (Visit 3), 120 seconds | 1 Month (Visit 3), 150 seconds | 1 Month (Visit 3), 180 seconds | 1 Month (Visit 3), 210 seconds | 1 Month (Visit 3), 240 seconds | 1 Month (Visit 3), 270 seconds | 1 Month (Visit 3), 300 seconds | 1 Month (Visit 3), All Times | |
| Botox | 3.2 | 5.0 | 5.1 | 4.3 | 3.5 | 2.3 | 1.5 | 0.9 | 0.7 | 0.3 | 0.2 | 2.5 |
| Saline | 3.8 | 6.2 | 6.2 | 5.7 | 4.5 | 3.3 | 2.2 | 1.4 | 0.9 | 0.6 | 0.4 | 3.2 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: 1 week from Baseline
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 Week (Visit 2), 0 seconds | 1 Week (Visit 2), 30 seconds | 1 Week (Visit 2), 60 seconds | 1 Week (Visit 2), 90 seconds | 1 Week (Visit 2), 120 seconds | 1 Week (Visit 2), 150 seconds | 1 Week (Visit 2), 180 seconds | 1 Week (Visit 2), 210 seconds | 1 Week (Visit 2), 240 seconds | 1 Week (Visit 2), 270 seconds | 1 Week (Visit 2), 300 seconds | 1 Week (Visit 2), All Times | |
| Botox | 3.3 | 5.4 | 5.9 | 4.9 | 3.7 | 2.7 | 2.0 | 1.4 | 0.9 | 0.6 | 0.4 | 2.8 |
| Saline | 4.0 | 6.7 | 6.9 | 6.1 | 4.8 | 3.8 | 2.7 | 1.9 | 1.3 | 0.9 | 0.7 | 3.6 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: 3 Months from Baseline
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 Months (Visit 4), 0 seconds | 3 Months (Visit 4), 30 seconds | 3 Months (Visit 4), 60 seconds | 3 Months (Visit 4), 90 seconds | 3 Months (Visit 4), 120 seconds | 3 Months (Visit 4), 150 seconds | 3 Months (Visit 4), 180 seconds | 3 Months (Visit 4), 210 seconds | 3 Months (Visit 4), 240 seconds | 3 Months (Visit 4), 270 seconds | 3 Months (Visit 4), 300 seconds | 3 Months (Visit 4), All Times | |
| Botox | 2.3 | 4.5 | 4.9 | 4.6 | 3.8 | 3.0 | 2.1 | 1.5 | 1.0 | 0.7 | 0.3 | 2.6 |
| Saline | 3.3 | 5.4 | 5.9 | 5.2 | 4.7 | 3.6 | 2.8 | 1.9 | 1.4 | 0.9 | 0.6 | 3.2 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: Baseline (Visit 1)
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (Visit 1), 0 seconds | Baseline (Visit 1), 30 seconds | Baseline (Visit 1), 60 seconds | Baseline (Visit 1), 90 seconds | Baseline (Visit 1), 120 seconds | Baseline (Visit 1), 150 seconds | Baseline (Visit 1), 180 seconds | Baseline (Visit 1), 210 seconds | Baseline (Visit 1), 240 seconds | Baseline (Visit 1), 270 seconds | Baseline (Visit 1), 300 seconds | Baseline (Visit 1), All Times | |
| Botox | 4.5 | 6.5 | 6.8 | 5.9 | 5.1 | 4.1 | 2.8 | 2.0 | 1.3 | 0.9 | 0.6 | 3.7 |
| Saline | 4.3 | 6.3 | 6.5 | 6.3 | 5.1 | 3.9 | 2.8 | 2.0 | 1.4 | 0.9 | 0.9 | 3.7 |
14 reviews available for formaldehyde and Disease Models, Animal
| Article | Year |
|---|---|
Formaldehyde exposure and leukemia: critical review and reevaluation of the results from a study that is the focus for evidence of biological plausibility.
Topics: Animals; Carcinogens; Chromosome Deletion; Chromosomes, Human, Pair 7; Chromosomes, Human, Pair 8; D | 2013 |
Immunopathogenesis associated with formaldehyde-inactivated RSV vaccine in preclinical and clinical studies.
Topics: Animals; Disease Models, Animal; Formaldehyde; Humans; Respiratory Syncytial Virus Infections; Respi | 2017 |
Hematological and toxicological evaluation of formaldehyde as a potential cause of human leukemia.
Topics: Animals; Bone Marrow; Disease Models, Animal; Disinfectants; Formaldehyde; Hematologic Tests; Humans | 2011 |
The orofacial formalin test.
Topics: Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Injections, Subcutaneous; Lip; Pain Meas | 2004 |
Involvement of antibody, complement and cellular immunity in the pathogenesis of enhanced respiratory syncytial virus disease.
Topics: Animals; Antibody Formation; Bronchopneumonia; Complement Activation; Disease Models, Animal; Formal | 2004 |
[Experimental methods in pain using neuropathic and inflammatory animal models].
Topics: Animals; Diagnostic Techniques, Neurological; Disease Models, Animal; Formaldehyde; Hot Temperature; | 2007 |
Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies?
Topics: Animals; Carcinogens, Environmental; Disease Models, Animal; Formaldehyde; Humans; Inhalation Exposu | 2008 |
Deafferentation in animals as a model for the study of pain: an alternative hypothesis.
Topics: Afferent Pathways; Animals; Capsaicin; Denervation; Disease Models, Animal; Formaldehyde; Hydroxydop | 1984 |
Species differences in methanol poisoning.
Topics: Acidosis; Animals; Blindness; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Formal | 1982 |
Spatial and temporal aspects of spinal cord and brainstem activation in the formalin pain model.
Topics: Animals; Behavior, Animal; Brain Stem; Deoxyglucose; Disease Models, Animal; Formaldehyde; Gene Expr | 1993 |
Methyl tert butyl ether systemic toxicity.
Topics: Absorption; Administration, Inhalation; Administration, Oral; Air Pollutants; Animals; Brain; Carbon | 1997 |
[Possibilities and limitations of the use of rat paw edemas as models of inflammation. 1. Review on edemas as models and their possible use].
Topics: Animals; Anti-Inflammatory Agents; Bradykinin; Carrageenan; Cell Migration Inhibition; Dextrans; Dis | 1975 |
Formaldehyde.
Topics: Animals; Disease Models, Animal; Formaldehyde; Humans; Maximum Allowable Concentration; Mice; Neopla | 1992 |
Animal models useful in the study of thrombosis and antithrombotic agents.
Topics: Animals; Blood Platelets; Blood Vessel Prosthesis; Blood Vessels; Dicumarol; Disease Models, Animal; | 1972 |
4 trials available for formaldehyde and Disease Models, Animal
| Article | Year |
|---|---|
Gene silencing of NR2B-containing NMDA receptor by intrathecal injection of short hairpin RNA reduces formalin-induced nociception in C57BL/6 mouse.
Topics: Animals; Disease Models, Animal; Formaldehyde; Gene Expression Regulation; Gene Silencing; Injection | 2013 |
An inactivated West Nile virus vaccine for domestic geese-efficacy study and a summary of 4 years of field application.
Topics: Adjuvants, Immunologic; Animals; Bird Diseases; Disease Models, Animal; Disinfectants; Formaldehyde; | 2005 |
Safety and immunogenicity of an oral, inactivated, whole-cell vaccine for Shigella sonnei: preclinical studies and a Phase I trial.
Topics: Administration, Oral; Adolescent; Adult; Animals; Antibodies, Bacterial; Antigens, Bacterial; Diseas | 2006 |
[Hepatocellular mechanisms of compensatory processes influenced by environmental chemical factors].
Topics: Adult; Animals; Benzene; Cell Count; Chemical and Drug Induced Liver Injury; Disease Models, Animal; | 1991 |
557 other studies available for formaldehyde and Disease Models, Animal
| Article | Year |
|---|---|
Aminoalkoxycarbonyloxymethyl Ether Prodrugs with a pH-Triggered Release Mechanism: A Case Study Improving the Solubility, Bioavailability, and Efficacy of Antimalarial 4(1
Topics: Administration, Oral; Animals; Antimalarials; Cyclization; Disease Models, Animal; Ethers; Female; H | 2021 |
Perfusion with 10% neutral-buffered formalin is equivalent to 4% paraformaldehyde for histopathology and immunohistochemistry in a mouse model of experimental autoimmune encephalomyelitis.
Topics: Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Fixatives; Formaldehyd | 2022 |
Spinal distribution of c-Fos activated neurons expressing enkephalin in acute and chronic pain models.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Enkephalins; Formaldehyde; Freund' | 2014 |
Optimising Golgi-Cox staining for use with perfusion-fixed brain tissue validated in the zQ175 mouse model of Huntington's disease.
Topics: Animals; Brain; Dendrites; Disease Models, Animal; Female; Fixatives; Formaldehyde; Huntington Disea | 2016 |
Mouse Models for Campylobacter jejuni Colonization and Infection.
Topics: Acute Disease; Age Factors; Animals; Campylobacter Infections; Campylobacter jejuni; Colony Count, M | 2017 |
Transcardial perfusion versus immersion fixation for assessment of peripheral nerve regeneration.
Topics: Animals; Artifacts; Axons; Cardiac Surgical Procedures; Disease Models, Animal; Dissection; Fixative | 2009 |
Assessment of gait in a rat model of myofascial inflammation using the CatWalk system.
Topics: Animals; Automation; Behavior, Animal; Biomechanical Phenomena; Calcitonin Gene-Related Peptide; Dis | 2011 |
The influence of inflammation on the expression of neuropeptides in the ileum-projecting primary sensory neurones in the pig.
Topics: Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; | 2003 |
Intratumoral injection of IL-2-activated NK cells enhances the antitumor effect of intradermally injected paraformaldehyde-fixed tumor vaccine in a rat intracranial brain tumor model.
Topics: Animals; Brain Neoplasms; Cancer Vaccines; Cytotoxicity Tests, Immunologic; Disease Models, Animal; | 2004 |
Vaccination with experimental feline immunodeficiency virus vaccines, based on autologous infected cells, elicits enhancement of homologous challenge infection.
Topics: Animals; Antibodies, Viral; Antibody Specificity; Antigens, Viral; Cats; Cells, Cultured; Coculture | 1999 |
Analysis of amyloid-like secondary structure in the Cryab-R120G knock-in mouse model of hereditary cataracts by two-dimensional infrared spectroscopy.
Topics: alpha-Crystallin B Chain; Amyloid; Animals; Cataract; Disease Models, Animal; Formaldehyde; Gene Kno | 2021 |
Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.
Topics: Alcohol Dehydrogenase; Animals; Brain; Cachexia; Cockayne Syndrome; Disease Models, Animal; DNA Dama | 2021 |
Multi-region local field potential signatures in response to the formalin-induced inflammatory stimulus in male rats.
Topics: Amygdala; Animals; Brain Waves; Disease Models, Animal; Disinfectants; Electrophysiological Phenomen | 2022 |
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity.
Topics: Aldehyde Oxidoreductases; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease | 2022 |
Evaluation of EDB Fibronectin in Plasma, Patient-Derived Xenograft Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tumor Tissues Using Immunoaffinity LC-MS/MS.
Topics: Animals; Breast Neoplasms; Chromatography, Liquid; Disease Models, Animal; Female; Fibronectins; For | 2022 |
Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior.
Topics: Animals; Disease Models, Animal; Formaldehyde; Hyperalgesia; Male; Migraine Disorders; Nitroglycerin | 2022 |
The modulatory role of dopamine receptors within the hippocampal cornu ammonis area 1 in stress-induced analgesia in an animal model of persistent inflammatory pain.
Topics: Analgesia; Animals; Benzazepines; Dimethyl Sulfoxide; Disease Models, Animal; Dopamine Antagonists; | 2022 |
Potential anti-arthritic and analgesic properties of essential oil and viridiflorol obtained from Allophylus edulis leaves in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dexamethasone; Dihydroxyphenylalanine; D | 2023 |
Long-term follow-up of intracerebroventricular injection of streptozotocin-inducing pain sensitization.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Follow-Up Studies; Formaldehyde; Pain; Rats; Str | 2022 |
Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; BCG Vaccine; Carrageenan; Disease Models, Animal; Ede | 2023 |
Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; BCG Vaccine; Carrageenan; Disease Models, Animal; Ede | 2023 |
Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; BCG Vaccine; Carrageenan; Disease Models, Animal; Ede | 2023 |
Analgesic and anti-inflammatory potential of ethanolic extract from Serjania erecta leaves.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; BCG Vaccine; Carrageenan; Disease Models, Animal; Ede | 2023 |
Topics: Analgesics; Animals; Disease Models, Animal; Ethanol; Fallopia japonica; Formaldehyde; Inflammation; | 2023 |
Spinal TASK-1 and TASK-3 modulate inflammatory and neuropathic pain.
Topics: Animals; Disease Models, Animal; Down-Regulation; Female; Formaldehyde; Ganglia, Spinal; Humans; Hyp | 2019 |
Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Pain; Disease Mo | 2019 |
Hydrogen Sulfide Ameliorates Cognitive Dysfunction in Formaldehyde-Exposed Rats: Involvement in the Upregulation of Brain-Derived Neurotrophic Factor.
Topics: Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; CA1 Region, Hippocampal; Cognitive Dys | 2020 |
Chemical composition and evaluation of the antinociceptive, antioxidant and antimicrobial effects of essential oil from Hymenaea cangaceira (Pinto, Mansano & Azevedo) native to Brazil: A natural medicine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Antioxidants; Brazil; Disease Models, Anima | 2020 |
The phthalimide analogues N-3-hydroxypropylphthalimide and N-carboxymethyl-3-nitrophthalimide exhibit activity in experimental models of inflammatory and neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Inflamma | 2019 |
The analgesic effect of refeeding on acute and chronic inflammatory pain.
Topics: Acute Pain; Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Eating; Food Deprivat | 2019 |
Zinc oxide nanoparticles synthesized from Fraxinus rhynchophylla extract by green route method attenuates the chemical and heat induced neurogenic and inflammatory pain models in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Fraxinus; Green Chemistry Technology; Hot | 2020 |
Bilateral Parkinson's disease model rats exhibit hyperalgesia to subcutaneous formalin administration into the vibrissa pad.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Formaldehyde; Hyperalgesia; Immunohistochemistry; | 2019 |
Formalin-induced and neuropathic pain altered time estimation in a temporal bisection task in rats.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Inflammation; Ligation; Male; Neura | 2019 |
Analgesic and antiallodynic activity of novel anticonvulsant agents derived from 3-benzhydryl-pyrrolidine-2,5-dione in mouse models of nociceptive and neuropathic pain.
Topics: Acute Pain; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Formaldehyde; Hep G2 Cells | 2020 |
Attenuated dopamine receptor signaling in nucleus accumbens core in a rat model of chemically-induced neuropathy.
Topics: Animals; Conditioning, Operant; Disease Models, Animal; Dopamine Agonists; Dopamine Antagonists; Dos | 2020 |
Effect of spinal angiotensin-converting enzyme 2 activation on the formalin-induced nociceptive response in mice.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Diminazene; Disease Models, | 2020 |
Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Formaldehyde; Humans; Inda | 2020 |
Piperidine propionamide as a scaffold for potent sigma-1 receptor antagonists and mu opioid receptor agonists for treating neuropathic pain.
Topics: Amides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Guinea Pigs | 2020 |
PCC0208009, an indirect IDO1 inhibitor, alleviates neuropathic pain and co-morbidities by regulating synaptic plasticity of ACC and amygdala.
Topics: Amygdala; Analgesics; Animals; Behavior, Animal; Comorbidity; Disease Models, Animal; Formaldehyde; | 2020 |
Poloxamer micellar system for intra-articular injection of 15-deoxy-
Topics: Animals; Anti-Inflammatory Agents; Arthralgia; Biological Availability; Chemotaxis, Leukocyte; Cytok | 2020 |
Repeated Administration of Baclofen Modulates TRPV-1 Channel Expression by PKC Pathway in Dorsal Root Ganglia of Spinal Cord in a Morphine Tolerance Model of Rats
Topics: Animals; Baclofen; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation | 2020 |
Acyclic Triterpenoid Isolated from
Topics: Alpinia; Animals; Anti-Inflammatory Agents; Cell Line; Cyclooxygenase 2; Disease Models, Animal; Dow | 2020 |
The Anti-Inflammatory Effect of Different Doses of Aliskiren in Rat Models of Inflammation.
Topics: Amides; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Relationship, Drug; | 2020 |
Evaluation of anti-inflammatory and analgesic activities of aqueous methanolic extract of Ranunculus muricatus in albino mice.
Topics: Acetic Acid; Albumins; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, A | 2020 |
Degradation of FA reduces Aβ neurotoxicity and Alzheimer-related phenotypes.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Disease Models, A | 2021 |
The modulatory role of β‑amyloid in the regulation of nociception in mice.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Injections, | 2020 |
The anti-inflammatory and analgesic activities of the ethyl acetate extract of Viburnum taitoense Hayata.
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; China; Cytok | 2021 |
In vivo and in vitro anti-inflammatory activity evaluation of Lebanese Cannabis sativa L. ssp. indica (Lam.).
Topics: Animals; Anti-Inflammatory Agents; Cannabis; Carrageenan; Disease Models, Animal; Edema; Flowers; Fo | 2021 |
Active components of Bupleurum chinense and Angelica biserrata showed analgesic effects in formalin induced pain by acting on Nav1.7.
Topics: Analgesics; Angelica; Animals; Bupleurum; CHO Cells; Cricetulus; Disease Models, Animal; Drugs, Chin | 2021 |
Anti-inflammatory activity of Nectandra angustifolia (Laurel Amarillo) ethanolic extract.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Cell Cycle; Cell Survival; Chroma | 2021 |
The synergistic effects of opioid and neuropeptide B/W in rat acute inflammatory and neuropathic pain models.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Drug Synergism; Drug Therapy, | 2021 |
Pain-like behavior in mice can be induced by the environmental context in which the pain stimulus was previously given.
Topics: Animals; Association Learning; Behavior, Animal; Chronic Pain; Conditioning, Classical; Disease Mode | 2021 |
Construction and theoretical insights into the ESIPT fluorescent probe for imaging formaldehyde in vitro and in vivo.
Topics: Alzheimer Disease; Animals; Brain; Density Functional Theory; Disease Models, Animal; Fluorescent Dy | 2021 |
Antinociceptive effect of intrathecal P7C3 via GABA in a rat model of inflammatory pain.
Topics: Analgesics; Animals; Calcium Signaling; Carbazoles; Disease Models, Animal; Formaldehyde; gamma-Amin | 2021 |
Functional expression of glycine receptors in DRG neurons of mice.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Glycin | 2021 |
Ethyl pyruvate ameliorate inflammatory response of sinonasal mucosa by inhibiting HMGB1 in rats with acute rhinosinusitis.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Formaldehyde; Gene Express | 2021 |
Comparison of analgesic activities of aconitine in different mice pain models.
Topics: Acetic Acid; Aconitine; Analgesics; Animals; Aspirin; Disease Models, Animal; Edema; Female; Formald | 2021 |
Effects of Spirulina platensis on pain and inflammation in long Evans rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Female; Formaldeh | 2020 |
Analgesic effect of voluntary exercise in a rat model of persistent pain via suppression of microglial activation in the spinal cord.
Topics: Analgesics; Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Chronic Pain; Disease Mo | 2021 |
The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Dic | 2021 |
Central and peripheral pain intervention by Ophiorrhizarugosa leaves: Potential underlying mechanisms and insight into the role of pain modulators.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Central N | 2021 |
TREK-1 potassium channels participate in acute and long-lasting nociceptive hypersensitivity induced by formalin in rats.
Topics: Animals; Disease Models, Animal; Disinfectants; Female; Formaldehyde; Ganglia, Spinal; Hyperalgesia; | 2021 |
GC-MS analysis, anticancer and anti-inflammatory activities of Saussurea hypoleuca spreng. Root.
Topics: Animals; Anti-Inflammatory Agents; Antineoplastic Agents; Carrageenan; Cell Proliferation; Cell Surv | 2021 |
Cannabidiol microinjection into the nucleus accumbens attenuated nociceptive behaviors in an animal model of tonic pain.
Topics: Animals; Cannabidiol; Disease Models, Animal; Formaldehyde; Male; Microinjections; Nociception; Nucl | 2021 |
Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels.
Topics: Analgesics; Animals; Berberine Alkaloids; CHO Cells; Corydalis; Cricetulus; Disease Models, Animal; | 2021 |
A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA.
Topics: Analgesics; Animals; Disease Models, Animal; Dopamine beta-Hydroxylase; Excitatory Amino Acid Agents | 2017 |
A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities.
Topics: Administration, Cutaneous; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; C | 2017 |
Skin thickness measurements increase with excision and biopsy processing procedures.
Topics: Analysis of Variance; Animals; Artifacts; Biopsy, Needle; Burns; Disease Models, Animal; Formaldehyd | 2017 |
Mapping of pain circuitry in early post-natal development using manganese-enhanced MRI in rats.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Brain Mapping; Chlorides; Disease Models, Animal; Fem | 2017 |
Long-term anti-itch effect of botulinum neurotoxin A is associated with downregulation of TRPV1 and TRPA1 in the dorsal root ganglia in mice.
Topics: Acetone; Animals; Botulinum Toxins, Type A; Chloroquine; Chronic Disease; Disease Models, Animal; Do | 2017 |
Variations of isovaline structure related to activity in the formalin foot assay in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Formaldehyde; Mice; Pain; Valine | 2017 |
Hydro-ethanolic leaf extract of Ziziphus abyssinica Hochst Ex A. Rich (Rhamnaceae) exhibits anti-nociceptive effects in murine models.
Topics: Acetic Acid; Africa; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; D | 2017 |
Benzoxazolinone aryl sulfonamides as potent, selective Na
Topics: Administration, Oral; Analgesics; Animals; Benzoxazoles; Biological Availability; Disease Models, An | 2017 |
Shrinkage of Nasal Mucosa and Cartilage During Formalin Fixation.
Topics: Animals; Cartilage; Disease Models, Animal; Formaldehyde; Nasal Mucosa; Sheep; Tissue Fixation | 2017 |
Rational Design of T Lymphocyte Epitope-Based Vaccines Against Coccidioides Infection.
Topics: Amino Acid Sequence; Animals; Antigens, Fungal; Coccidioides; Coccidioidomycosis; Computational Biol | 2017 |
Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue.
Topics: Aging; Alzheimer Disease; Animals; Biosensing Techniques; Brain; Cell Line; Disease Models, Animal; | 2017 |
Differential effects of formaldehyde exposure on airway inflammation and bronchial hyperresponsiveness in BALB/c and C57BL/6 mice.
Topics: Allergens; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, | 2017 |
Report: Analgesic and anti-inflammatory activity of aqueous-methanolic extract of Aerva javanica.
Topics: Acetic Acid; Amaranthaceae; Analgesics; Animals; Anti-Inflammatory Agents; Chondrus; Disease Models, | 2017 |
Antinociceptive effect of botulinum toxin A involves alterations in AMPA receptor expression and glutamate release in spinal dorsal horn neurons.
Topics: Analgesics, Non-Narcotic; Animals; Axonal Transport; Botulinum Toxins, Type A; Cell Membrane; Cells, | 2017 |
Sinomenine produces peripheral analgesic effects via inhibition of voltage-gated sodium currents.
Topics: Animals; Antirheumatic Agents; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, | 2017 |
Activation of P2X3 receptors in the cerebrospinal fluid-contacting nucleus neurons reduces formalin-induced pain behavior via PAG in a rat model.
Topics: Adenosine Triphosphate; Animals; Cerebrospinal Fluid; Cholera Toxin; Disease Models, Animal; Disinfe | 2017 |
Adult Zebrafish (Danio rerio): An Alternative Behavioral Model of Formalin-Induced Nociception.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Disease Mode | 2017 |
Carvedilol can attenuate histamine-induced paw edema and formaldehyde-induced arthritis in rats without risk of gastric irritation.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Carbazoles; Carve | 2017 |
A Fluorogenic Probe for Ultrafast and Reversible Detection of Formaldehyde in Neurovascular Tissues.
Topics: Alzheimer Disease; Animals; Cerebral Cortex; Coumarins; Disease Models, Animal; Fluorescent Dyes; Fo | 2017 |
Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT
Topics: Analgesics; Animals; Antineoplastic Agents; Cyclohexanes; Diabetic Neuropathies; Disease Models, Ani | 2017 |
MSA prions exhibit remarkable stability and resistance to inactivation.
Topics: alpha-Synuclein; Animals; Biological Transport; Brain; Detergents; Disease Models, Animal; Fixatives | 2018 |
Mediating Role of TRPV1 Ion Channels in the Co-exposure to PM2.5 and Formaldehyde of Balb/c Mice Asthma Model.
Topics: Air Pollutants; Animals; Asthma; Disease Models, Animal; Formaldehyde; Mice, Inbred BALB C; Oxidativ | 2017 |
Toluene exposure enhances acute and chronic formalin-induced nociception in rats: Participation of 5-HT
Topics: Animals; Disease Models, Animal; Disinfectants; Dose-Response Relationship, Drug; Female; Formaldehy | 2017 |
Vitamin E Reversed Apoptosis of Cardiomyocytes Induced by Exposure to High Dose Formaldehyde During Mice Pregnancy.
Topics: Animals; Animals, Newborn; Antioxidants; Apoptosis; Blotting, Western; Disease Models, Animal; Enzym | 2017 |
Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment.
Topics: Animals; Capsaicin; Dermatitis, Atopic; Disease Models, Animal; Formaldehyde; Humans; Infant, Newbor | 2017 |
Synthesis, antinociceptive activity and structure activity relationship of flavone derivatives.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Flavones; Formaldehyde; | 2017 |
Role of thalamic ventral posterolateral nucleus histamine H
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Histamine; Hist | 2017 |
Chronic Monosodium Glutamate Administration Induced Hyperalgesia in Mice.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Adm | 2017 |
A novel mouse model of atopic dermatitis that is T helper 2 (Th2)-polarized by an epicutaneous allergen.
Topics: Allergens; Animals; Dermatitis, Atopic; Detergents; Dinitrochlorobenzene; Disease Models, Animal; Fe | 2018 |
Magnesium sulfate reduces formalin-induced orofacial pain in rats with normal magnesium serum levels.
Topics: Analgesics; Animals; Behavior, Animal; Biomarkers; Creatine Kinase; Disease Models, Animal; Facial P | 2018 |
Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Formaldehyde; | 2018 |
Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain.
Topics: Animals; Brain-Derived Neurotrophic Factor; Carrageenan; Chronic Pain; Disease Models, Animal; Femal | 2018 |
Role of D1- and D2-like dopaminergic receptors in the nucleus accumbens in modulation of formalin-induced orofacial pain: Involvement of lateral hypothalamus.
Topics: Analgesics; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Carbachol; Disease Models, Anim | 2018 |
Anti-nociceptive effect of methanol extract of leaves of Senna singueana in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationsh | 2018 |
Antinociceptive effects of novel epibatidine analogs through activation of α4β2 nicotinic receptors.
Topics: Analgesics, Non-Narcotic; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Co | 2018 |
Sex differences in antinociceptive response to Δ-9-tetrahydrocannabinol and CP 55,940 in the mouse formalin test.
Topics: Analgesics; Analysis of Variance; Animals; Cyclohexanols; Disease Models, Animal; Dose-Response Rela | 2018 |
Inhibitory effects of fluoxetine, an antidepressant drug, on masseter muscle nociception at the trigeminal subnucleus caudalis and upper cervical spinal cord regions in a rat model of psychophysical stress.
Topics: Animals; Antidepressive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine | 2018 |
Illumination with 630 nm Red Light Reduces Oxidative Stress and Restores Memory by Photo-Activating Catalase and Formaldehyde Dehydrogenase in SAMP8 Mice.
Topics: Aldehyde Oxidoreductases; Animals; Catalase; Disease Models, Animal; Formaldehyde; Light; Male; Memo | 2019 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehy | 2018 |
LASSBio-1586, an N-acylhydrazone derivative, attenuates nociceptive behavior and the inflammatory response in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Carrage | 2018 |
Exposure to formaldehyde and diisononyl phthalate exacerbate neuroinflammation through NF-κB activation in a mouse asthma model.
Topics: Animals; Asthma; Disease Models, Animal; Encephalitis; Formaldehyde; Gene Expression Regulation; Int | 2018 |
Synthesis, In-vivo and In-vitro Anti-inflammatory Evaluation of some Novel Coumarin Derivatives.
Topics: Albumins; Animals; Anti-Inflammatory Agents; Celecoxib; Coumarins; Disease Models, Animal; Dose-Resp | 2018 |
Alzheimer's Disease-Like Pathologies and Cognitive Impairments Induced by Formaldehyde in Non-Human Primates.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition Disorders; Disease Models, Anima | 2018 |
Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues.
Topics: Animals; Antigens; Antigens, Differentiation; Breast Neoplasms; Buffers; Cell Line, Tumor; Cell Sepa | 2019 |
Analgesic and anti-edemic properties of etifoxine in models of inflammatory sensitization.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Formaldeh | 2019 |
Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Anim | 2019 |
Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity.
Topics: Acetic Acid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Formald | 2019 |
Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels.
Topics: Analgesics, Non-Narcotic; Animals; Animals, Outbred Strains; Anti-Inflammatory Agents; Diclofenac; D | 2019 |
Long-lasting bladder overactivity and bladder afferent hyperexcitability in rats with chemically-induced prostatic inflammation.
Topics: Animals; Disease Models, Animal; Formaldehyde; Male; Neurons, Afferent; Patch-Clamp Techniques; Pros | 2019 |
The Optimal Concentration of Formaldehyde is Key to Stabilizing the Pre-Fusion Conformation of Respiratory Syncytial Virus Fusion Protein.
Topics: Animals; Antibodies, Neutralizing; Antibodies, Viral; Cell Line; Disease Models, Animal; Epitopes; F | 2019 |
Antipyretic and anti-nociceptive effects of methanol extract of leaves of Fimbristylis miliacea in mice model.
Topics: Acetic Acid; Analgesics; Animals; Antipyretics; Cyperaceae; Disease Models, Animal; Female; Fever; F | 2019 |
Tannic acid exhibits anti-inflammatory effects on formalin-induced paw edema model of inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Female; Foot; Formaldehyde; Peroxi | 2019 |
The effect of hydroethanolic extract of Matricaria chamomilla on the reproductive system of male rats exposed to formaldehyde.
Topics: Animals; Antioxidants; Apoptosis; Disease Models, Animal; Dose-Response Relationship, Drug; Environm | 2019 |
Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain.
Topics: Animals; Behavior, Animal; Biopterins; Biosynthetic Pathways; Capsaicin; Chromatography, High Pressu | 2013 |
Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats.
Topics: Animals; Behavior, Animal; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Disease Models, Anima | 2013 |
Activity of nicorandil, a nicotinamide derivative with a nitrate group, in the experimental model of pain induced by formaldehyde in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Glyburi | 2013 |
Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats.
Topics: Action Potentials; Affective Symptoms; Analysis of Variance; Aniline Compounds; Animals; Arginine; C | 2013 |
TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate.
Topics: Acetic Acid; Acid Sensing Ion Channels; Acute Pain; Administration, Oral; Analgesics; Animals; Disea | 2013 |
Systemic synergism between codeine and morphine in three pain models in mice.
Topics: Acetic Acid; Acute Pain; Analgesics, Opioid; Animals; Behavior, Animal; Codeine; Disease Models, Ani | 2013 |
Role of 5-HT₁B/₁D receptors in the reduction of formalin-induced nociception and secondary allodynia/hyperalgesia produced by antimigraine drugs in rats.
Topics: Acute Pain; Animals; Biphenyl Compounds; Chronic Pain; Dihydroergotamine; Disease Models, Animal; Dr | 2013 |
Synthesis and biological evaluation of some novel thieno[2,3-d] pyrimidine derivatives as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response | 2013 |
Role of transient receptor potential ion channels and evoked levels of neuropeptides in a formaldehyde-induced model of asthma in BALB/c mice.
Topics: Acetanilides; Animals; Asthma; Calcitonin Gene-Related Peptide; Capsaicin; Disease Models, Animal; E | 2013 |
Antinociceptive synergy between diclofenac and morphine after local injection into the inflamed site.
Topics: Acute Pain; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; | 2013 |
Porcine lens nuclei as a model for comparison of 3 ultrasound modalities regarding efficiency and chatter.
Topics: Animals; Cataract; Disease Models, Animal; Fixatives; Formaldehyde; High-Energy Shock Waves; Humans; | 2013 |
Different peripheral tissue injury induces differential phenotypic changes of spinal activated microglia.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Calcium-Binding Proteins; CD11b An | 2013 |
NESS002ie: a new fluorinated thiol endopeptidase inhibitor with antinociceptive activity in an animal model of persistent pain.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Male; Mice; Naloxone; Pain, Intractable; | 2013 |
The triterpenoid fraction from Trichosanthes dioica root suppresses experimentally induced inflammatory ascites in rats.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Ascites; Disease Models, Animal; Dose-Response | 2013 |
Formaldehyde inhalation reduces respiratory mechanics in a rat model with allergic lung inflammation by altering the nitric oxide/cyclooxygenase-derived products relationship.
Topics: Administration, Inhalation; Airway Resistance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bro | 2013 |
Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain.
Topics: Analgesics; Animals; Benzamides; Blood-Brain Barrier; Brain; Capillary Permeability; Cell Line; Dise | 2013 |
Ethanolic extract of Aconiti Brachypodi Radix attenuates nociceptive pain probably via inhibition of voltage-dependent Na⁺ channel.
Topics: Acetic Acid; Aconitum; Analgesics; Animals; Dinoprostone; Disease Models, Animal; Dose-Response Rela | 2012 |
Impaired endocannabinoid signalling in the rostral ventromedial medulla underpins genotype-dependent hyper-responsivity to noxious stimuli.
Topics: Animals; Cannabinoid Receptor Modulators; Depression; Disease Models, Animal; Endocannabinoids; Form | 2014 |
Different role of spinal 5-HT(hydroxytryptamine)7 receptors and descending serotonergic modulation in inflammatory pain induced in formalin and carrageenan rat models.
Topics: Animals; Carrageenan; Disease Models, Animal; Formaldehyde; Hyperalgesia; Inflammation; Male; Pain; | 2014 |
Sigma-1 receptor antagonist, BD1047 reduces nociceptive responses and phosphorylation of p38 MAPK in mice orofacial formalin model.
Topics: Analgesics; Animals; Disease Models, Animal; Ethylenediamines; Facial Pain; Formaldehyde; Lip; Male; | 2014 |
Effects of Papaver rhoeas (L.) extract on formalin-induced pain and inflammation in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Corticosterone; Disease Models, Animal; Dose-Response | 2012 |
Analgesic effects of Huwentoxin-IV on animal models of inflammatory and neuropathic pain.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Inflammati | 2014 |
Effects of dominant/subordinate social status on formalin-induced pain and changes in serum proinflammatory cytokine concentrations in mice.
Topics: Animals; Body Weight; Corticosterone; Disease Models, Animal; Dominance-Subordination; Formaldehyde; | 2013 |
The protective effect of L-carnitine against hippocampal damage due to experimental formaldehyde intoxication in rats.
Topics: Animals; Carnitine; Disease Models, Animal; Formaldehyde; Hippocampus; Immunohistochemistry; Male; O | 2014 |
Effects of formalin-inactivated respiratory syncytial virus (FI-RSV) in the perinatal lamb model of RSV.
Topics: Animals; Animals, Newborn; Antigens, Viral; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Fo | 2013 |
Possible mechanism involved in the antinociceptive activity of dimer of paederosidic acid and paederosidic acid methyl ester in mice.
Topics: Analgesics; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2014 |
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor.
Topics: Animals; Bicuculline; Botulinum Toxins, Type A; Disease Models, Animal; Drug Administration Routes; | 2014 |
The putative role of ovary removal and progesterone when considering the effect of formaldehyde exposure on lung inflammation induced by ovalbumin.
Topics: Animals; Cell Degranulation; Disease Models, Animal; Female; Formaldehyde; Interleukin-10; Leukocyte | 2013 |
Antinociceptive and anti-inflammatory effects of flavonoids PMT1 and PMT2 isolated from Piper montealegreanum Yuncker (Piperaceae) in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Disease Models, Animal; Edema; Flavonoids; | 2014 |
Antinociceptive esters of N-methylanthranilic acid: Mechanism of action in heat-mediated pain.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship | 2014 |
Antinociceptive effect of certain dimethoxy flavones in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationsh | 2014 |
Hydroalcoholic extract of Rosemary (Rosmarinus officinalis L.) and its constituent carnosol inhibit formalin-induced pain and inflammation in mice.
Topics: Abietanes; Alcohols; Analgesics; Animals; Anti-Inflammatory Agents; Corticosterone; Cyclooxygenase 1 | 2013 |
Study on analgesic and anti-inflammatory properties of Cordia myxa fruit hydro-alcoholic extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Cordia; Disease Models | 2013 |
From peripheral to central: the role of ERK signaling pathway in acupuncture analgesia.
Topics: Acupuncture Analgesia; Animals; Blotting, Western; Butadienes; Disease Models, Animal; Enzyme Inhibi | 2014 |
Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice.
Topics: Administration, Inhalation; Affect; Animals; Aromatherapy; Benzazepines; Disease Models, Animal; Dop | 2014 |
Activation of peripheral KCNQ channels attenuates inflammatory pain.
Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Disease Models, Animal; Electric Stim | 2014 |
Intraganglionar resiniferatoxin prevents orofacial inflammatory and neuropathic hyperalgesia.
Topics: Animals; Capsaicin; Carrageenan; Cold Temperature; Disease Models, Animal; Diterpenes; Facial Pain; | 2014 |
A novel mechanism for endogenous formaldehyde elevation in SAMP8 mouse.
Topics: Aging; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Alzheim | 2014 |
The use of mouse models of breast cancer and quantitative image analysis to evaluate hormone receptor antigenicity after microwave-assisted formalin fixation.
Topics: Algorithms; Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Fem | 2014 |
Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1.
Topics: Animals; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; HEK293 Cells; Humans; Membrane Glyco | 2014 |
Entropic imaging of cataract lens: an in vitro study.
Topics: Animals; Cataract; Computer Simulation; Disease Models, Animal; Entropy; Feasibility Studies; Formal | 2014 |
Exposure to low doses of formaldehyde during pregnancy suppresses the development of allergic lung inflammation in offspring.
Topics: Air Pollutants; Alveolitis, Extrinsic Allergic; Animals; Asthma; Birth Weight; Cytokines; Disease Mo | 2014 |
The methanol extract of Euonymus laxiflorus, Rubia lanceolata and Gardenia jasminoides inhibits xanthine oxidase and reduce serum uric acid level in rats.
Topics: Animals; Disease Models, Animal; Euonymus; Formaldehyde; Gardenia; Gout; Hyperuricemia; Nociception; | 2014 |
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord.
Topics: Animals; Disease Models, Animal; Formaldehyde; Histamine; Immunohistochemistry; Male; Nociception; P | 2014 |
Intra-periaqueductal gray infusion of zeta inhibitory peptide attenuates pain-conditioned place avoidance in rats.
Topics: Analgesics; Animals; Avoidance Learning; Cell-Penetrating Peptides; Conditioning, Psychological; Dis | 2014 |
Effect of probenecid on the pain-related behaviour and morphological markers in orofacial formalin test of the rat.
Topics: Analgesics; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Injections, Intraperitoneal; | 2015 |
Role of the cerebrospinal fluid-contacting nucleus in the descending inhibition of spinal pain transmission.
Topics: Animals; Brain Stem; Cerebrospinal Fluid; Cholera Toxin; Disease Models, Animal; Formaldehyde; Heart | 2014 |
Synthesis and analgesic effects of μ-TRTX-Hhn1b on models of inflammatory and neuropathic pain.
Topics: Acetic Acid; Analgesics; Animals; Disease Models, Animal; Formaldehyde; HEK293 Cells; Humans; Inflam | 2014 |
Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney, one-clip hypertensive rats.
Topics: Animals; Blood Pressure; Chromatography, Liquid; Disease Models, Animal; Formaldehyde; Glomerular Fi | 2014 |
Aldehyde dehydrogenase-2 regulates nociception in rodent models of acute inflammatory pain.
Topics: Acetaldehyde; Acute Pain; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Be | 2014 |
Aβ seeds resist inactivation by formaldehyde.
Topics: Age Factors; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Auto | 2014 |
Anti-inflammatory properties of convolutamydine A and two structural analogues.
Topics: Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Cell Line; Cyclooxygenase 2; Cytok | 2014 |
Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats.
Topics: Analgesics, Opioid; Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Formaldehyd | 2014 |
TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.
Topics: Animals; Butadienes; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signa | 2014 |
Upregulation of neuregulin-1 reverses signs of neuropathic pain in rats.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Gang | 2014 |
Epidural administration of neostigmine-loaded nanofibers provides extended analgesia in rats.
Topics: Analgesics; Animals; Behavior, Animal; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Delayed | 2014 |
Chimeric agents derived from the functionalized amino acid, lacosamide, and the α-aminoamide, safinamide: evaluation of their inhibitory actions on voltage-gated sodium channels, and antiseizure and antinociception activities and comparison with lacosamid
Topics: Acetamides; Alanine; Analgesics; Animals; Anticonvulsants; Benzylamines; Cells, Cultured; Cerebral C | 2015 |
Role of TRPV1 and ASIC3 in formalin-induced secondary allodynia and hyperalgesia.
Topics: Acid Sensing Ion Channels; Amiloride; Animals; Blotting, Western; Capsaicin; Cnidarian Venoms; Disea | 2014 |
Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-diones.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Formaldeh | 2014 |
Quantification of the effect of Lipo-PGE1 on angiogenesis.
Topics: Alprostadil; Animals; Biopsy, Needle; Collagen; Disease Models, Animal; Formaldehyde; Immunohistoche | 2015 |
Neurochemical properties of BDNF-containing neurons projecting to rostral ventromedial medulla in the ventrolateral periaqueductal gray.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Disease Mod | 2014 |
Utilization of spray drying technique for improvement of dissolution and anti-inflammatory effect of Meloxicam.
Topics: Aerosols; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buffers; Calorimetry, Differential Scann | 2015 |
Antinociceptive and anti-inflammatory activity of the siaresinolic acid, a triterpene isolated from the leaves of Sabicea grisea Cham. & Schltdl. var. grisea.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Formaldehyde; In | 2015 |
Genetically engineered mouse models to study prostate cancer.
Topics: Animals; Disease Models, Animal; Dissection; Eosine Yellowish-(YS); Formaldehyde; Genetic Engineerin | 2015 |
Neural mechanism underlying hyperalgesic response to orofacial pain in Parkinson's disease model rats.
Topics: Animals; Corpus Striatum; Disease Models, Animal; Facial Pain; Formaldehyde; Hyperalgesia; Male; Oxi | 2015 |
Comparison of venturi and peristaltic vacuum in phacoemulsification.
Topics: Animals; Disease Models, Animal; Fixatives; Formaldehyde; High-Energy Shock Waves; Lens Nucleus, Cry | 2015 |
Effect of different fixative solutions on eyes with experimental proliferative vitreoretinopathy.
Topics: Animals; Disease Models, Animal; Eye; Female; Fibrosis; Fixatives; Formaldehyde; Glutaral; Histocyto | 2015 |
Intrathecal RGS4 inhibitor, CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Rel | 2015 |
The effects of levetiracetam, sumatriptan, and caffeine in a rat model of trigeminal pain: interactions in 2-component combinations.
Topics: Analgesics; Animals; Behavior, Animal; Caffeine; Disease Models, Animal; Dose-Response Relationship, | 2015 |
Extracts of Leptadenia hastata Leaf, a Famine Food and Traditional Remedy for Furuncles, Suppress Inflammation in Murine Models.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; Apocynaceae; Arthritis; Capillary Permeability; Carr | 2016 |
Activation of peripheral KCNQ channels relieves gout pain.
Topics: Action Potentials; Animals; Animals, Newborn; Arthritis; Benzbromarone; Cells, Cultured; CHO Cells; | 2015 |
Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice.
Topics: Acetanilides; Analgesics; Animals; Benzamides; Capsaicin; Cold Temperature; Disease Models, Animal; | 2015 |
Therapeutic role of curcumin in oxidative DNA damage caused by formaldehyde.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Administration, Oral; Amyloid beta-Peptides; Animals; Antioxidants; Blo | 2015 |
Chondroprotective effects of a new glucosamine combination in rats: Gene expression, biochemical and histopathological evaluation.
Topics: Animals; Bromelains; Cartilage; Chondroitin Sulfates; Dimethyl Sulfoxide; Disease Models, Animal; Dr | 2015 |
Formaldehyde inhalation during pregnancy abolishes the development of acute innate inflammation in offspring.
Topics: Active Transport, Cell Nucleus; Acute Lung Injury; Air Pollutants; Animals; Cytokines; Disease Model | 2015 |
The major histocompatibility complex genes impact pain response in DA and DA.1U rats.
Topics: Animals; Animals, Congenic; Disease Models, Animal; Disinfectants; Female; Formaldehyde; Gene Expres | 2015 |
GABA acting on GABAB receptors located in a medullary pain facilitatory area enhances nociceptive behaviors evoked by intraplantar formalin injection.
Topics: Animals; Baclofen; Disease Models, Animal; Formaldehyde; GABA-B Receptor Agonists; GABA-B Receptor A | 2015 |
Repeated forced swim stress differentially affects formalin-evoked nociceptive behaviour and the endocannabinoid system in stress normo-responsive and stress hyper-responsive rat strains.
Topics: Amygdala; Animals; Disease Models, Animal; Endocannabinoids; Formaldehyde; Functional Laterality; Ge | 2016 |
Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer.
Topics: Aminopyridines; Analgesics; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone a | 2015 |
Role of the thalamic submedius nucleus histamine H1 and H 2 and opioid receptors in modulation of formalin-induced orofacial pain in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Histamine Agonists; | 2015 |
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Cycloox | 2015 |
Sodium Hydroxide Pinpoint Pressing Permeation Method for the Animal Modeling of Sick Sinus Syndrome.
Topics: Animals; Disease Models, Animal; Electrophysiologic Techniques, Cardiac; Female; Formaldehyde; Heart | 2015 |
Antinociceptive properties of selective MT(2) melatonin receptor partial agonists.
Topics: Acetamides; Acetaminophen; Analgesics; Aniline Compounds; Animals; Behavior, Animal; Brain; Disease | 2015 |
Observing Anti-inflammatory and Anti-nociceptive Activities of Glycyrrhizin Through Regulating COX-2 and Pro-inflammatory Cytokines Expressions in Mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Cyc | 2015 |
Neuropathic Pain Phenotype Does Not Involve the NLRP3 Inflammasome and Its End Product Interleukin-1β in the Mice Spared Nerve Injury Model.
Topics: Animals; Behavior, Animal; Carrier Proteins; Disease Models, Animal; Female; Formaldehyde; Inflammas | 2015 |
The H2S-producing enzyme CSE is dispensable for the processing of inflammatory and neuropathic pain.
Topics: Animals; Cystathionine gamma-Lyase; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expr | 2015 |
Diverse effects of Brilliant Blue G administration in models of trigeminal activation in the rat.
Topics: Analgesics, Non-Narcotic; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Drug Eva | 2015 |
EphrinB-EphB signaling regulates spinal pain processing via PKCγ.
Topics: Analysis of Variance; Animals; Bone Neoplasms; Disease Models, Animal; Ephrin-B2; Formaldehyde; Hype | 2015 |
Clonidine Reduces Nociceptive Responses in Mouse Orofacial Formalin Model: Potentiation by Sigma-1 Receptor Antagonist BD1047 without Impaired Motor Coordination.
Topics: Adrenergic alpha-2 Receptor Agonists; Analgesics; Animals; Blood Pressure; Clonidine; Disease Models | 2015 |
Withania somnifera (L.) Dunal root extract alleviates formalin-induced nociception in mice: involvement of the opioidergic system.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; For | 2016 |
Gabapentin Effects on PKC-ERK1/2 Signaling in the Spinal Cord of Rats with Formalin-Induced Visceral Inflammatory Pain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amines; Animals; Behavior, Animal; Cell Membrane; Cyc | 2015 |
Ginsenoside Rb1 Attenuates Acute Inflammatory Nociception by Inhibition of Neuronal ERK Phosphorylation by Regulation of the Nrf2 and NF-κB Pathways.
Topics: Analgesics; Animals; Astrocytes; Disease Models, Animal; Dose-Response Relationship, Drug; Extracell | 2016 |
Pharmacological modulation of neuropathic pain-related depression of behavior: effects of morphine, ketoprofen, bupropion and [INCREMENT]9-tetrahydrocannabinol on formalin-induced depression of intracranial self-stimulation in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Bupropion; Depression; Disease Models, Animal; Dose-Respons | 2016 |
Analgesic Effects of Danggui-Shaoyao-San on Various "Phenotypes" of Nociception and Inflammation in a Formalin Pain Model.
Topics: Analgesics; Animals; Behavior, Animal; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Dr | 2016 |
[Effect of formaldehyde inhalation on allergic rhinitis in mice].
Topics: Animals; Antigens, Dermatophagoides; Arthropod Proteins; Cysteine Endopeptidases; Disease Models, An | 2015 |
Descending nociceptive inhibition is modulated in a time-dependent manner in a double-hit model of chronic/tonic pain.
Topics: Animals; Chromatography, Liquid; Chronic Pain; Disease Models, Animal; Formaldehyde; Hyperalgesia; M | 2016 |
Antinociceptive and anti-inflammatory effects of a Geissospermum vellosii stem bark fraction.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apocynaceae; Carrageenan; Disease Models, Animal; Ede | 2016 |
Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Bind | 2016 |
Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Behavior, Animal; Cyclopropanes; Disease Models, Animal; | 2016 |
Synthesis and Biological Evaluation of Novel σ1 Receptor Ligands for Treating Neuropathic Pain: 6-Hydroxypyridazinones.
Topics: Analgesics, Non-Narcotic; Animals; Chemistry Techniques, Synthetic; Disease Models, Animal; Dose-Res | 2016 |
Systemic TAK-242 prevents intrathecal LPS evoked hyperalgesia in male, but not female mice and prevents delayed allodynia following intraplantar formalin in both male and female mice: The role of TLR4 in the evolution of a persistent pain state.
Topics: Animals; Behavior, Animal; Chronic Pain; Disease Models, Animal; Disinfectants; Female; Formaldehyde | 2016 |
Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Calcium; Chalcones; Disease Models, Animal; Dose-Resp | 2016 |
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heter | 2016 |
Amylin modulates the formalin-induced tonic pain behaviours in rats.
Topics: Amylin Receptor Agonists; Animals; Brain; Disease Models, Animal; Formaldehyde; Injections, Spinal; | 2016 |
Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines.
Topics: Acetates; Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Anima | 2016 |
Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-α-bisabolol, its main compound, in mice.
Topics: Analgesics; Animals; Anti-Infective Agents; Capsaicin; Carrageenan; Disease Models, Animal; Dose-Res | 2016 |
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injecti | 2016 |
Tabernaemontana catharinensis ethyl acetate fraction presents antinociceptive activity without causing toxicological effects in mice.
Topics: Acetates; Acetic Acid; Administration, Oral; Analgesics; Animals; Apocynaceae; Behavior, Animal; Cap | 2016 |
Evidence for the Participation of Acid-Sensing Ion Channels (ASICs) in the Antinociceptive Effect of Curcumin in a Formalin-Induced Orofacial Inflammatory Model.
Topics: Acid Sensing Ion Channels; Action Potentials; Animals; Curcumin; Disease Models, Animal; Face; Forma | 2017 |
The mitogen and stress-activated protein kinase 1 regulates the rapid epigenetic tagging of dorsal horn neurons and nocifensive behaviour.
Topics: 5,6-Dihydroxytryptamine; Acute Pain; Adrenergic Uptake Inhibitors; Animals; Capsaicin; Desipramine; | 2016 |
Hormonal and molecular effects of restraint stress on formalin-induced pain-like behavior in male and female mice.
Topics: Analysis of Variance; Animals; Corticosterone; Disease Models, Animal; Female; Fixatives; Formaldehy | 2016 |
Porcine cataract creation using formalin or microwave treatment for an ophthalmology wet lab.
Topics: Animals; Cataract; Disease Models, Animal; Education, Medical, Graduate; Formaldehyde; Lens, Crystal | 2016 |
The role of trigeminal nucleus caudalis orexin 1 receptor in orofacial pain-induced anxiety in rat.
Topics: Animals; Anxiety; Benzoxazoles; Capsaicin; Disease Models, Animal; Exploratory Behavior; Facial Pain | 2016 |
Cinobufagin enhances the protective efficacy of formalin-inactivated Salmonella typhimurium vaccine through Th1 immune response.
Topics: Adjuvants, Immunologic; Alum Compounds; Animals; Antibodies, Bacterial; Bufanolides; Cell Proliferat | 2016 |
Antinociceptive and anticonvulsant effects of the monoterpene linalool oxide.
Topics: Acetic Acid; Acyclic Monoterpenes; Analgesics; Animals; Anticonvulsants; Behavior, Animal; Cyclohexa | 2017 |
A comparative assessment of two kynurenic acid analogs in the formalin model of trigeminal activation: a behavioral, immunohistochemical and pharmacokinetic study.
Topics: Analgesics; Animals; Chromatography, High Pressure Liquid; Disease Models, Animal; Facial Pain; Form | 2017 |
N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cannabinoid Receptor Antagonists; Cohort S | 2016 |
Preclinical evaluation of a chemically detoxified pneumolysin as pneumococcal vaccine antigen.
Topics: Animals; Antibodies, Bacterial; Antigens, Bacterial; Bacterial Proteins; Disease Models, Animal; Fem | 2017 |
Anti-oxidant, anti-inflammatory, analgesic and antipyretic activities of grapevine leaf extract (Vitis vinifera) in mice and identification of its active constituents by LC-MS/MS analyses.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Antipyretics; Behavior, An | 2016 |
CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice.
Topics: Anemia, Sickle Cell; Anesthetics, Local; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein | 2016 |
(-)-α-Bisabolol reduces orofacial nociceptive behavior in rodents.
Topics: Acrolein; Administration, Oral; Administration, Topical; Analgesics; Animals; Behavior, Animal; Bind | 2017 |
The Antinociceptive Effect of a Tapentadol-Ketorolac Combination in a Mouse Model of Trigeminal Pain is Mediated by Opioid Receptors and ATP-Sensitive K
Topics: Analgesics; Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Facial Pain; | 2017 |
Effects of intra-hippocampal microinjection of vitamin B
Topics: Analgesics; Animals; CA1 Region, Hippocampal; Catheters, Indwelling; Disease Models, Animal; Dose-Re | 2017 |
Formaldehyde-Induced Aggravation of Pruritus and Dermatitis Is Associated with the Elevated Expression of Th1 Cytokines in a Rat Model of Atopic Dermatitis.
Topics: Animals; Cytokines; Dermatitis, Atopic; Disease Models, Animal; Disinfectants; Formaldehyde; Immunog | 2016 |
The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn.
Topics: Animals; Central Nervous System Sensitization; Disease Models, Animal; Face; Formaldehyde; Hindlimb; | 2017 |
Biomarker-Based PET Imaging of Diffuse Intrinsic Pontine Glioma in Mouse Models.
Topics: Animals; Biomarkers, Tumor; Brain Stem Neoplasms; Chickens; Disease Models, Animal; Formaldehyde; Gl | 2017 |
Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice.
Topics: Acetic Acid; Analgesics; Animals; Cyclic GMP; Dalbergia; Disease Models, Animal; Drug Evaluation, Pr | 2017 |
Evaluation of acute toxicity, sedative and analgesic effects of Taverniera glabra methanolic extract on mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Central Nervous System; Disease Models, Animal; | 2016 |
Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States.
Topics: Acetic Acid; Animals; Capsaicin; Corticosterone; Cues; Disease Models, Animal; Formaldehyde; Male; M | 2017 |
Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain.
Topics: Animals; Biomarkers; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expression; Gene Kn | 2017 |
Effect of Low Dose Lead (Pb) Administration on Tail Immersion Test and Formalin-induced Pain in Wistar Rats: Possible Modulatory Role of Cobalt (II) Chloride.
Topics: Animals; Behavior, Animal; Cobalt; Disease Models, Animal; Female; Formaldehyde; Male; Organometalli | 2017 |
Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice.
Topics: Acute Disease; Analgesics; Animals; Chronic Pain; Disease Models, Animal; Drug Therapy, Combination; | 2017 |
Activation of the NMDA receptor-neuronal nitric oxide synthase pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain.
Topics: Animals; Conditioning, Operant; Cyclic N-Oxides; Disease Models, Animal; Excitatory Postsynaptic Pot | 2017 |
Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Fixatives; Formaldehyde; Functional Laterality; g | 2008 |
Quercetin: further investigation of its antinociceptive properties and mechanisms of action.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cholinergic Agents; Disease Models, | 2008 |
Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X(2/3) receptor function and exerts an analgesic effect in pain models.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Bone Density Conservation Ag | 2008 |
Development of maxillary accessory ostium following sinusitis in rabbits.
Topics: Animals; Disease Models, Animal; Formaldehyde; Maxillary Sinus; Maxillary Sinusitis; Mucociliary Cle | 2008 |
Antinociceptive action of GLYX-13: an N-methyl-D-aspartate receptor glycine site partial agonist.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2008 |
Sensitivity analysis of biologically motivated model for formaldehyde-induced respiratory cancer in humans.
Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Formaldehyde; Humans; Models, Biol | 2008 |
Free radical scavenging and anti-inflammatory properties of Lagerstroemia speciosa (L).
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Disease Models, Animal; Dose-Response | 2008 |
Anti-inflammatory and analgesic properties in a rodent model of a (1-->3),(1-->6)-linked beta-glucan isolated from Pleurotus pulmonarius.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillary Permeability | 2008 |
Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dex | 2008 |
Mechanisms involved in the antinociceptive effect caused by diphenyl diselenide in the formalin test.
Topics: Administration, Oral; Analgesics; Animals; Benzene Derivatives; Calcium; Cyclic GMP; Disease Models, | 2008 |
Alterations of AQP2 expression in trigeminal ganglia in a murine inflammation model.
Topics: Animals; Aquaporin 1; Aquaporin 2; Disease Models, Animal; Formaldehyde; Gene Expression Regulation; | 2009 |
Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice.
Topics: Analysis of Variance; Anesthetics; Animals; Arginine; Diazepam; Disease Models, Animal; Dose-Respons | 2009 |
Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; Formaldehyde; | 2009 |
Pharmacological assessment of the rat formalin test utilizing the clinically used analgesic drugs gabapentin, lamotrigine, morphine, duloxetine, tramadol and ibuprofen: influence of low and high formalin concentrations.
Topics: Analgesics; Animals; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Form | 2009 |
Antinociceptive effects of hydroalcoholic extract of Thymus vulgaris.
Topics: Analgesics; Animals; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Formal | 2009 |
Involvement of activated astrocyte and microglia of locus coeruleus in cardiac pain processing after acute cardiac injury.
Topics: Acute Disease; Animals; Astrocytes; CD11b Antigen; Disease Models, Animal; Formaldehyde; Glial Fibri | 2009 |
Eating is a protected behavior even in the face of persistent pain in male rats.
Topics: Animals; Disease Models, Animal; Disinfectants; Dose-Response Relationship, Drug; Facial Pain; Feedi | 2009 |
Intrathecal gabapentin does not act as a hyperpolarization-activated cyclic nucleotide-gated channel activator in the rat formalin test.
Topics: Amines; Analgesics; Animals; Cardiotonic Agents; Cyclic Nucleotide-Gated Cation Channels; Cyclohexan | 2009 |
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
Topics: Administration, Oral; Animals; Cell Line; Constriction, Pathologic; Disease Models, Animal; Drug Dis | 2009 |
Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Din | 2009 |
Antinociceptive activity of Amaranthus spinosus in experimental animals.
Topics: Acetic Acid; Amaranthus; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carr | 2009 |
Combined microwave energy and fixative agent for cataract induction in pig eyes.
Topics: Animals; Cataract; Cornea; Disease Models, Animal; Drug Combinations; Eye Enucleation; Fixatives; Fo | 2009 |
Antinociceptive effects of (O-methyl)-N-benzoyl tyramine (riparin I) from Aniba riparia (Nees) Mez (Lauraceae) in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Arginine; Behavior, Anim | 2009 |
The Rac GTPase-activating bacterial protein toxin CNF1 induces analgesia up-regulating mu-opioid receptors.
Topics: Analgesics; Animals; Bacterial Toxins; Cell Line, Tumor; Cerebellum; Disease Models, Animal; Dose-Re | 2009 |
Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies.
Topics: Animals; Body Weight; Chronic Disease; Cold Temperature; Disease Models, Animal; Formaldehyde; Hot T | 2009 |
Licking decreases phosphorylation of extracellular signal-regulated kinase in the dorsal horn of the spinal cord after a formalin test.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Down-Regulation; Extracellular Signal-Regulated M | 2009 |
Irritant and adjuvant effects of gaseous formaldehyde on the ovalbumin-induced hyperresponsiveness and inflammation in a rat model.
Topics: Air Pollutants; Air Pollution, Indoor; Animals; Asthma; Bronchial Hyperreactivity; Bronchoalveolar L | 2009 |
Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease.
Topics: Animals; Antibodies, Neutralizing; Cross Protection; Disease Models, Animal; Encephalomyelitis; Ente | 2010 |
Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia.
Topics: Age Factors; Aging; Alzheimer Disease; Amyloid beta-Protein Precursor; Angiotensin Amide; Animals; C | 2011 |
Spinal macrophage migration inhibitory factor contributes to the pathogenesis of inflammatory hyperalgesia in rats.
Topics: Analysis of Variance; Animals; CD47 Antigen; Cells, Cultured; Disease Models, Animal; Dose-Response | 2010 |
An animal model of chronic rheumatic valvulitis induced by formalin-killed streptococci.
Topics: Animals; Antigens, Bacterial; Disease Models, Animal; Female; Formaldehyde; Heart; Heart Valve Disea | 2010 |
Formalin-induced short- and long-term modulation of Cav currents expressed in Xenopus oocytes: an in vitro cellular model for formalin-induced pain.
Topics: Animals; Calcium Channels; Cell Death; Disease Models, Animal; Female; Formaldehyde; Oocytes; Pain; | 2010 |
Screening of antinociceptive components in Corydalis yanhusuo W.T. Wang by comprehensive two-dimensional liquid chromatography/tandem mass spectrometry.
Topics: Alkaloids; Animals; Chromatography, High Pressure Liquid; Corydalis; Disease Models, Animal; Dose-Re | 2010 |
Pharmacological evaluation of analgesic effects of the cholecystokinin2 receptor antagonist Z-360 in mouse models of formalin- and cancer-induced pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodiazepinones; Cell Line, Tumor; Disease Model | 2010 |
Synergism between COX-3 inhibitors in two animal models of pain.
Topics: Acetaminophen; Animals; Cyclooxygenase Inhibitors; Dipyrone; Disease Models, Animal; Drug Synergism; | 2010 |
Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models.
Topics: Acetic Acid; Analgesics; Animals; Anthocyanins; Blueberry Plants; Diclofenac; Disease Models, Animal | 2010 |
N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system.
Topics: Administration, Oral; Analgesics; Animals; Antipyrine; Behavior, Animal; Carrageenan; Chronic Diseas | 2010 |
Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception.
Topics: Animals; Antigens, CD1; Disease Models, Animal; Formaldehyde; Histocompatibility Antigens Class I; M | 2010 |
Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Ethan | 2010 |
Bayesian analysis of a rat formaldehyde DNA-protein cross-link model.
Topics: Animals; Bayes Theorem; Cross-Linking Reagents; Disease Models, Animal; DNA; DNA Damage; Formaldehyd | 2010 |
A diminished response to formalin stimulation reveals a role for the glutamate transporters in the altered pain sensitivity of mice with experimental autoimmune encephalomyelitis (EAE).
Topics: Amino Acid Sequence; Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; F | 2010 |
Intracisternal administration of NR2 antagonists attenuates facial formalin-induced nociceptive behavior in rats.
Topics: Animals; Behavior, Animal; Cisterna Magna; Disease Models, Animal; Excitatory Amino Acid Antagonists | 2010 |
Influence of apical foramen widening and sealer on the healing of chronic periapical lesions induced in dogs' teeth.
Topics: Animals; Bismuth; Bone Resorption; Calcium Hydroxide; Dental Cementum; Dexamethasone; Disease Models | 2010 |
Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2010 |
Prenatal exposure to methamphetamine alters the mechanical withdrawal threshold and tonic hyperalgesia in the offspring.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Birth Weight; Body Temperature; Body W | 2010 |
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; | 2010 |
The effect of intra-locus coeruleus injection of 17beta-estradiol on inflammatory pain modulation in male rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Disease Models, Animal; Estradiol; Estro | 2010 |
Antinociceptive effect of butyl (2-phenylethynyl) selenide on formalin test in mice: Evidences for the involvement of serotonergic and adenosinergic systems.
Topics: Administration, Oral; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2010 |
Analgesic effects of the ethanolic extract from Magnolia ovata (Magnoliaceae) trunk bark and of N-acetylxylopine, a semi-synthetic analogue of xylopine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aporphines; Carrageenan; Disease Models, | 2011 |
Involvement of kappa opioid receptors in the formalin-induced inhibition of analgesic tolerance to morphine via suppression of conventional protein kinase C activation.
Topics: Analgesics, Opioid; Animals; Brain; Chronic Disease; Disease Models, Animal; Down-Regulation; Drug T | 2010 |
Antinociceptive and anti-inflammatory effects of Costus spicatus in experimental animals.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Costus; Disease Models, Ani | 2010 |
The antinociceptive effects of AR-A014418, a selective inhibitor of glycogen synthase kinase-3 beta, in mice.
Topics: Abdominal Pain; Aggression; Analgesics; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non | 2011 |
Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models.
Topics: Animals; Capsaicin; Cell Count; Disease Models, Animal; Formaldehyde; gamma-Aminobutyric Acid; Gene | 2010 |
Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors.
Topics: Animals; Behavior, Animal; Caspases; Disease Models, Animal; Dose-Response Relationship, Drug; Forma | 2010 |
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Carragee | 2010 |
Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.
Topics: Amygdala; Animals; Behavior, Animal; Dipeptides; Disease Models, Animal; Excitatory Postsynaptic Pot | 2010 |
Enhanced nociceptive responding in two rat models of depression is associated with alterations in monoamine levels in discrete brain regions.
Topics: Analysis of Variance; Animals; Area Under Curve; Biogenic Monoamines; Brain; Chromatography, High Pr | 2010 |
Inter-strain differences of serotonergic inhibitory pain control in inbred mice.
Topics: Animals; Chronic Disease; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Infla | 2010 |
Morphine exposure in early life increases nociceptive behavior in a rat formalin tonic pain model in adult life.
Topics: Age Factors; Analgesics, Opioid; Analysis of Variance; Anesthetics, Dissociative; Animals; Animals, | 2011 |
The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain.
Topics: Animals; Body Weight; Depression; Disease Models, Animal; Escape Reaction; Formaldehyde; Hindlimb; H | 2010 |
Antinociceptive effect of extract of Emilia sonchifolia in mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Asteraceae; Behavior, Animal; Brazil; Disease Models, Anim | 2011 |
Spinal transient receptor potential ankyrin 1 channel contributes to central pain hypersensitivity in various pathophysiological conditions in the rat.
Topics: Acetanilides; Analysis of Variance; Animals; Ankyrins; Calcium Channels; Capsaicin; Cholecystokinin; | 2011 |
Role of peripheral 5-HT(4), 5-HT(6), and 5-HT(7) receptors in development and maintenance of secondary mechanical allodynia and hyperalgesia.
Topics: Animals; Anti-Asthmatic Agents; Area Under Curve; Cromolyn Sodium; Disease Models, Animal; Dose-Resp | 2011 |
RNA interference-mediated gene silence of the NR1 subunit of the NMDA receptor by subcutaneous injection of vector-encoding short hairpin RNA reduces formalin-induced nociception in the rat.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Ge | 2011 |
Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Disease Models, Animal; | 2011 |
Spinal phosphinositide 3-kinase-Akt-mammalian target of rapamycin signaling cascades in inflammation-induced hyperalgesia.
Topics: Androstadienes; Animals; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug | 2011 |
Synergistic interaction between intrathecal ginsenosides and morphine on formalin-induced nociception in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, | 2011 |
The orofacial formalin test in mice revisited--effects of formalin concentration, age, morphine and analysis method.
Topics: Age Factors; Analgesics, Opioid; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Irritan | 2011 |
Formalin-inactivated vaccine provokes cross-protective immunity in a mouse model of human enterovirus 71 infection.
Topics: Animals; Antibodies, Neutralizing; Antibodies, Viral; Cross Protection; Disease Models, Animal; Ente | 2011 |
Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models of acute and chronic pain.
Topics: Acute Disease; Anesthesia; Animals; Behavior, Animal; Chronic Disease; Cyclic P-Oxides; Disease Mode | 2011 |
Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep.
Topics: Aminobutyrates; Animals; Behavior, Animal; Benzhydryl Compounds; Disease Models, Animal; Dose-Respon | 2011 |
Interaction between histamine and morphine at the level of the hippocampus in the formalin-induced orofacial pain in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Facial Pain; Formaldehyde; Hippocampus; Histami | 2011 |
Synergism between dexketoprofen and meloxicam in an orofacial formalin test was not modified by opioid antagonists.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Dose-Response Relationship | 2011 |
Preemptive analgesic effects of midazolam and diclofenac in rat model.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Fo | 2011 |
Stress-induced hyperalgesia is associated with a reduced and delayed GABA inhibitory control that enhances post-synaptic NMDA receptor activation in the spinal cord.
Topics: Analgesics; Animals; Diazepam; Disease Models, Animal; Excitatory Postsynaptic Potentials; Flumazeni | 2011 |
Triterpenes involved in the anti-inflammatory effect of ethanolic extract of Pterodon emarginatus Vogel stem bark.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Chemical Fractionation; Croton Oil; Dise | 2012 |
Molecular and electrophysiological changes in the prefrontal cortex-amygdala-dorsal periaqueductal grey pathway during persistent pain state and fear-conditioned analgesia.
Topics: Amygdala; Animals; Biophysics; Conditioning, Psychological; Disease Models, Animal; Electric Stimula | 2011 |
Involvement of subtypes γ and ε of protein kinase C in colon pain induced by formalin injection.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Colonic Diseases; Dise | 2011 |
Analgesic effects and anti-inflammatory properties of the crude methanolic extract of Schwenckia americana Linn (Solanaceae).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Re | 2011 |
A novel conditioned nociceptive response in mice.
Topics: Acoustic Stimulation; Adjuvants, Anesthesia; Analysis of Variance; Animals; Conditioning, Classical; | 2011 |
Poincaré plot descriptors of heart rate variability as markers of persistent pain expression in freely moving rats.
Topics: Algorithms; Animals; Body Temperature; Carrageenan; Disease Models, Animal; Formaldehyde; Heart Rate | 2011 |
Erythropoietin reduces neuronal cell death and hyperalgesia induced by peripheral inflammatory pain in neonatal rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Cell Death; Cerebrovascular Circula | 2011 |
Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Benzothiazoles; Biphenyl C | 2011 |
Antinociceptive and hypnotic properties of Celastrus orbiculatus.
Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; F | 2011 |
Inflammation-induced changes in the chemical coding pattern of colon-projecting neurons in the inferior mesenteric ganglia of the pig.
Topics: Animals; Cell Count; Cell Survival; Colitis; Colon; Disease Models, Animal; Enteric Nervous System; | 2012 |
Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats.
Topics: Analgesics; Animals; Disease Models, Animal; Electroacupuncture; Formaldehyde; Gyrus Cinguli; Inflam | 2011 |
[Altered collagene characteristics and lysyl oxidase activity in lathyrism].
Topics: Animals; Aorta, Thoracic; Body Weight; Bone and Bones; Collagen; Disease Models, Animal; Formaldehyd | 2011 |
Anti-inflammatory and antinociceptive effects of the stem bark of Byrsonima intermedia A. Juss.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Chromatography, High P | 2011 |
Analgesic effects of cannabinoid receptor agonist WIN55,212-2 in the nucleus cuneiformis in animal models of acute and inflammatory pain in rats.
Topics: Analgesics; Analysis of Variance; Animals; Area Under Curve; Benzoxazines; Cannabinoid Receptor Agon | 2011 |
Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat.
Topics: Acoustic Stimulation; Animals; Conditioning, Classical; Cues; Disease Models, Animal; Fear; Formalde | 2012 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde | 2011 |
Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha, and Boswellia carterii.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Boswellia; Carrageenan; Chromatography, Liquid; Commi | 2012 |
Subacute arsenic exposure through drinking water reduces the pharmacodynamic effects of ketoprofen in male rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arsenites; Carrageenan; Cycl | 2012 |
Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice.
Topics: Acetone; Analgesics, Opioid; Animals; Capsaicin; Clomipramine; Disease Models, Animal; Formaldehyde; | 2011 |
Transient receptor potential vanilloid 1 - a polymodal nociceptive receptor - plays a crucial role in formaldehyde-induced skin inflammation in mice.
Topics: Animals; Capsaicin; Disease Models, Animal; Drug Eruptions; Female; Formaldehyde; Inflammation; Mice | 2012 |
Pain threshold variations in female rats as a function of the estrus cycle.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Estrous Cycle; Female; Formaldehyde; Hot Temperat | 2011 |
Anti-nociceptive and anti-inflammatory properties of the ethanolic extract of Lagenaria breviflora whole fruit in rat and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cucurbitaceae; Disease Mode | 2011 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxet | 2012 |
Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents.
Topics: Acetic Acid; Administration, Oral; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Asteraceae; B | 2012 |
Accumulated hippocampal formaldehyde induces age-dependent memory decline.
Topics: Animals; Blotting, Western; Cells, Cultured; Cerebral Cortex; Chromatography, High Pressure Liquid; | 2013 |
The activation of urocortin immunoreactive neurons in the Einger-Westphal nucleus following stress in rats.
Topics: Acute Disease; Animals; Disease Models, Animal; Fluorescent Antibody Technique; Formaldehyde; Immuno | 2001 |
Evaluation of disease modifying activity of Coriandrum sativum in experimental models.
Topics: Animals; Arthritis, Rheumatoid; Coriandrum; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; | 2012 |
Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms.
Topics: Analgesics, Opioid; Animals; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Dru | 2012 |
Formaldehyde up-regulates TRPV1 through MAPK and PI3K signaling pathways in a rat model of bone cancer pain.
Topics: Animals; Bone Neoplasms; Disease Models, Animal; Female; Formaldehyde; Ganglia, Spinal; MAP Kinase S | 2012 |
Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillaries; Carrageen | 2012 |
Comparison of analgesic effects of single versus repeated injection of botulinum toxin in orofacial formalin test in rats.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Drug Administration Schedule; | 2013 |
Oleaginous extract from the fruits Pterodon pubescens Benth induces antinociception in animal models of acute and chronic pain.
Topics: Acute Pain; Analgesics; Animals; Anti-Inflammatory Agents; Chronic Pain; Cold Temperature; Complex R | 2012 |
Antinociceptive effects of intrathecal landiolol injection in a rat formalin pain model.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Injections, Spinal; Male; Morpholines; Pa | 2012 |
Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat.
Topics: Action Potentials; Amygdala; Animals; Bicuculline; Carrageenan; Chromones; Disease Models, Animal; E | 2013 |
Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection.
Topics: Adrenomedullin; Animals; Astrocytes; Behavior, Animal; Calcitonin Gene-Related Peptide; Calcitonin R | 2012 |
Anti-inflammatory and analgesic properties of the ethanolic extract of Cnidoscolus aconitifolius in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2011 |
Comparative study between original and traditional method in establishing a chronic sinus node damage model in rabbit.
Topics: Action Potentials; Administration, Topical; Animals; Chronic Disease; Disease Models, Animal; Electr | 2012 |
Semi-mechanistic modeling of the interaction between the central and peripheral effects in the antinociceptive response to lumiracoxib in rats.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Female; | 2012 |
Anti-inflammatory, anti-bacterial activity and structure-activity relationships of substitutions on 4-thiazolidinone derivatives - Part-1.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacteria; Carrageenan; Disease Models, Ani | 2012 |
Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Disease Models, Animal; Doublecortin Protein; Formald | 2013 |
N-(4-Methoxy-2-nitrophenyl)hexadecanamide, a palmitoylethanolamide analogue, reduces formalin-induced nociception.
Topics: Amidohydrolases; Analgesics; Aniline Compounds; Animals; Arachidonic Acids; Disease Models, Animal; | 2012 |
Antinociceptive effects of radon inhalation on formalin-induced inflammatory pain in mice.
Topics: Administration, Inhalation; Air Pollutants, Radioactive; Analgesics; Animals; Behavior, Animal; Cell | 2013 |
Immunization of mice with formalin-inactivated spores from avirulent Bacillus cereus strains provides significant protection from challenge with Bacillus anthracis Ames.
Topics: Animals; Anthrax; Bacillus anthracis; Bacillus cereus; Bacterial Vaccines; Disease Models, Animal; F | 2013 |
Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Arginine; Behavior, Animal; Cymenes; Disease Model | 2012 |
Antinociceptive effect of Lecythis pisonis Camb. (Lecythidaceae) in models of acute pain in mice.
Topics: Acetic Acid; Acute Pain; Analgesics; Animals; Arginine; Behavior, Animal; Capsaicin; Disease Models, | 2013 |
Anti-inflammatory, analgesic, and antioxidant activities of Pisonia aculeata: folk medicinal use to scientific approach.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carr | 2013 |
Involvement of EphB1 receptors signalling in models of inflammatory and neuropathic pain.
Topics: Animals; Carrageenan; Cell Count; Disease Models, Animal; Electrophysiological Phenomena; Female; Fo | 2013 |
Aggravation of atopic dermatitis-like symptoms by consecutive low concentration of formaldehyde exposure in NC/Nga mice.
Topics: Administration, Inhalation; Animals; Cyclooxygenase 2; Dermatitis, Atopic; Disease Models, Animal; D | 2013 |
Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dantrolene; | 2002 |
Formaldehyde enhances mite allergen-induced eosinophilic inflammation in the murine airway.
Topics: Allergens; Animals; Asthma; Cytokines; Disease Models, Animal; Disinfectants; Eosinophils; Formaldeh | 2002 |
Formalin-induced cataract in goat eyes as a surgical training model for phacoemulsification.
Topics: Animals; Capsulorhexis; Cataract; Cataract Extraction; Disease Models, Animal; Formaldehyde; Goats; | 2002 |
Substance P gene expression in acute experimental colitis.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene | 1995 |
Novel drug designing approach for dual inhibitors as anti-inflammatory agents: implication of pyridine template.
Topics: Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Design; E | 2003 |
Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones.
Topics: Animals; Disease Models, Animal; Female; Formaldehyde; Gene Deletion; Male; Mice; Mice, Inbred C57BL | 2003 |
Anti-allodynic effect of NW-1029, a novel Na(+) channel blocker, in experimental animal models of inflammatory and neuropathic pain.
Topics: Amides; Animals; Ataxia; Behavior, Animal; Chronic Disease; Disease Models, Animal; Dose-Response Re | 2003 |
Stimulation signal modification in a porcine model for suppression of unstable detrusor contractions.
Topics: Animals; Disease Models, Animal; Electric Stimulation; Electric Stimulation Therapy; Electrodes, Imp | 2003 |
Exercising animal models in inhalation toxicology: interactions with ozone and formaldehyde.
Topics: Animals; Disease Models, Animal; Disinfectants; Drug Interactions; Exercise; Fever; Formaldehyde; Hu | 2003 |
The algogenic-induced nociceptive flexion test in mice: studies on sensitivity of the test and stress on animals.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Bites and Stings; Bradykinin; Corticosterone; Dis | 2003 |
Effects of TNF-alpha injected intracisternally on the nociceptive jaw-opening reflex and orofacial formalin test in freely moving rats.
Topics: Animals; Antineoplastic Agents; Cisterna Magna; Disease Models, Animal; Fixatives; Formaldehyde; Jaw | 2003 |
Characterization of formaldehyde-inactivated poliovirus preparations made from live-attenuated strains.
Topics: Animals; Antibodies, Viral; Cell Line; Disease Models, Animal; Formaldehyde; Humans; Immunization; M | 2003 |
Gabapentin reverses mechanical allodynia induced by sciatic nerve ischemia and formalin-induced nociception in mice.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models | 2003 |
Activation of p38 mitogen-activated protein kinase in spinal microglia is a critical link in inflammation-induced spinal pain processing.
Topics: Animals; Cyclooxygenase 2; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Formaldehyd | 2003 |
Cataract induction in pig eyes using viscoelastic endothelial protection and a formaldehyde-methanol mixture.
Topics: Animals; Cataract; Cytoprotection; Disease Models, Animal; Drug Combinations; Endothelium, Corneal; | 2003 |
Involvement of NMDA receptors in Zif/268 expression in the trigeminal nucleus caudalis following formalin injection into the rat whisker pad.
Topics: Animals; Cell Count; Disease Models, Animal; Dizocilpine Maleate; DNA-Binding Proteins; Early Growth | 2003 |
A new chloroquinolinyl chalcone derivative as inhibitor of inflammatory and immune response in mice and rats.
Topics: Abdominal Injuries; Administration, Oral; Animals; Arthritis, Experimental; Blood Platelets; Cell Li | 2003 |
Evaluation of the anti-inflammatory, anti-nociceptive and gastric effects of Ginkgo biloba in the rat.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; C | 2004 |
The effects of exposure to repeated minor pain during the neonatal period on formalin pain behaviour and thermal withdrawal latencies.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Anim | 2003 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
SSR240612 [(2R)-2-[((3R)-3-(1,3-benzodioxol-5-yl)-3-[[(6-methoxy-2-naphthyl)sulfonyl]amino]propanoyl)amino]-3-(4-[[2R,6S)-2,6-dimethylpiperidinyl]methyl]phenyl)-N-isopropyl-N-methylpropanamide hydrochloride], a new nonpeptide antagonist of the bradykinin
Topics: Administration, Oral; Analgesics; Animals; Bradykinin B1 Receptor Antagonists; CHO Cells; Cricetinae | 2004 |
Increased renal fibrosis and expression of renal phosphatidylinositol 4-kinase-beta and phospholipase C(gamma1) proteins in piglets exposed to ochratoxin-A.
Topics: 1-Phosphatidylinositol 4-Kinase; Animals; Diet; Disease Models, Animal; Enzyme Induction; Female; Fi | 2004 |
A protective effect of epidermal powder immunization in a mouse model of equine herpesvirus-1 infection.
Topics: Administration, Cutaneous; Animals; Antibodies, Viral; Cattle; Cell Line; COS Cells; Disease Models, | 2004 |
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Formaldehyde; Hot | 2004 |
Specific Inhibition of IkappaB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats.
Topics: Active Transport, Cell Nucleus; Analgesics; Animals; Anti-Inflammatory Agents; Cells, Cultured; Cycl | 2004 |
Effects of coadministration of cannabinoids and morphine on nociceptive behaviour, brain monoamines and HPA axis activity in a rat model of persistent pain.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Body Temperature; Brain; Brain Chemistry; Cannabidio | 2004 |
Differential immunogenic and neurogenic inflammatory responses in an allergic mouse model exposed to low levels of formaldehyde.
Topics: Administration, Inhalation; Animals; Bronchoalveolar Lavage Fluid; Cells, Cultured; Chemokines; Cult | 2004 |
Acoustic radiation force impulse imaging of thermally- and chemically-induced lesions in soft tissues: preliminary ex vivo results.
Topics: Animals; Catheter Ablation; Cattle; Disease Models, Animal; Formaldehyde; Image Processing, Computer | 2004 |
Tissue injury models of persistent nociception in rats.
Topics: Animals; Disease Models, Animal; Formaldehyde; Hindlimb; Pain Measurement; Pain Threshold; Rats | 2004 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cycl | 2004 |
Nonspecific antiviral immunity by formalin-fixed Coxiella burnetii is enhanced in the absence of nitric oxide.
Topics: Animals; Antigens, Bacterial; Bacterial Vaccines; Coxiella burnetii; Disease Models, Animal; Female; | 2004 |
A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model.
Topics: Amides; Analgesics; Animals; Binding Sites; Biphenyl Compounds; Brain; Cell Line; Disease Models, An | 2004 |
Potentiation of antihyperalgesic activity of diclofenac by nimodipine in a formalin model of facial pain in rats.
Topics: Animals; Calcium Channel Blockers; Diclofenac; Disease Models, Animal; Dose-Response Relationship, D | 2004 |
Analgesic effect of TT-232, a heptapeptide somatostatin analogue, in acute pain models of the rat and the mouse and in streptozotocin-induced diabetic mechanical allodynia.
Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzoquinones; Diabetes Mellitus, Experimental | 2004 |
Alterations in spinal cord gene expression after hindpaw formalin injection.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Functional La | 2004 |
Prevention by celecoxib of secondary hyperalgesia induced by formalin in rats.
Topics: Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Disease Models, A | 2004 |
Intrathecal propofol has analgesic effects on inflammation-induced pain in rats.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Hot Temperature; Inflammation; Injections | 2004 |
Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats.
Topics: Animals; Antipyrine; Behavior, Animal; Disease Models, Animal; Disinfectants; Dose-Response Relation | 2005 |
Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Disinfectants; | 2005 |
Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae).
Topics: Acetic Acid; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non- | 2005 |
Effect of formaldehyde gas exposure in a murine allergic contact hypersensitivity model.
Topics: Administration, Cutaneous; Animals; Dermatitis, Allergic Contact; Disease Models, Animal; Environmen | 2005 |
Spinal CK2 regulates nociceptive signaling in models of inflammatory pain.
Topics: Animals; Casein Kinase II; Disease Models, Animal; Formaldehyde; Hyperalgesia; Inflammation; Male; M | 2005 |
Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Cell Line, Tumor; Disease | 2004 |
Atrial gradient as a potential predictor of atrial fibrillation.
Topics: Animals; Atrial Fibrillation; Cardiac Pacing, Artificial; Disease Models, Animal; Dogs; Electrocardi | 2005 |
Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: a c-Fos study.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Male; Morphine; | 2005 |
Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain.
Topics: Acetamides; Animals; Arthritis; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Dru | 2006 |
Hippocampal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression is decreased in rat models of pain and stress.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, | 2005 |
The influence of experimental ileitis on the neuropeptide coding of enteric neurons in the pig.
Topics: Animals; Case-Control Studies; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Fo | 2005 |
Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease.
Topics: Acute Disease; Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Chronic Disease; Colitis; Cyc | 2005 |
Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats.
Topics: Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relation | 2005 |
Central serotonin 3 receptors play an important role in the modulation of nociceptive neural activity of trigeminal subnucleus caudalis and nocifensive orofacial behavior in rats with persistent temporomandibular joint inflammation.
Topics: Action Potentials; Administration, Topical; Analysis of Variance; Animals; Behavior, Animal; Disease | 2005 |
Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice.
Topics: Animals; Behavior, Animal; Carrageenan; Cisplatin; Disease Models, Animal; Formaldehyde; Hyperalgesi | 2005 |
Evaluation of interaction between intrathecal adenosine and MK801 or NBQX in a rat formalin pain model.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal | 2005 |
Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Baclofen; Behavior, Animal; Disease Models, Anima | 2005 |
Long-term egg-yolk adaptation of the Orientia tsutsugamushi for preparation of a formalinized immunogen.
Topics: Adaptation, Biological; Animals; Antibodies, Bacterial; Bacterial Proteins; Bacterial Vaccines; Blot | 2006 |
A simple technique of formalin vapour fixation of lung in experimental animals.
Topics: Animals; Disease Models, Animal; Equipment Design; Fixatives; Formaldehyde; Guinea Pigs; Lung; Photo | 1968 |
Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Electrophysiology; Formaldehyde; G | 2006 |
Synchrotron microradiography study on acute lung injury of mouse caused by PM(2.5) aerosols.
Topics: Aerosols; Air Pollutants; Animals; Cells, Cultured; Disease Models, Animal; Disease Progression; Fer | 2006 |
Inflammation-susceptible Lewis rats show less sensitivity than resistant Fischer rats in the formalin inflammatory pain test and with repeated thermal testing.
Topics: Analysis of Variance; Animals; Animals, Newborn; Area Under Curve; Behavior, Animal; Corticosterone; | 2006 |
Formalin injection into knee joints of rats: pharmacologic characterization of a deep somatic nociceptive model.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; GABA Agents; Histamine | 2006 |
Macrophage colony-stimulating factor aggravates rather than regenerates emphysematous lungs in mice.
Topics: Animals; Disease Models, Animal; Emphysema; Formaldehyde; Macrophage Colony-Stimulating Factor; Male | 2006 |
Antinociceptive effects of tetrodotoxin (TTX) in rodents.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relation | 2006 |
Interferential therapy produces antinociception during application in various models of inflammatory pain.
Topics: Animals; Carrageenan; Disease Models, Animal; Edema; Fixatives; Formaldehyde; Hyperalgesia; Inflamma | 2006 |
Examination of the interaction between peripheral diclofenac and gabapentin on the 5% formalin test in rats.
Topics: Amines; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclohexanecarboxylic Acids; D | 2006 |
Histopathological comparison of topical therapy modalities for acute radiation proctitis in an experimental rat model.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Betamethasone; Diseas | 2006 |
Contribution of peripheral 5-HT2A or 5-HT3 receptors to Fos expression in the trigeminal spinal nucleus produced by acute injury to the masseter muscle during persistent temporomandibular joint inflammation in rats.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Freund's Adjuvant; | 2006 |
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid.
Topics: Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-S | 2006 |
Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice.
Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Benzoates; Carrageenan; Dinucleoside Phosphates | 2007 |
The orofacial formalin test in the mouse: a behavioral model for studying physiology and modulation of trigeminal nociception.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Capsaicin; Disease Models, Anima | 2006 |
Antinociceptive effects of the aqueous extract of Brugmansia suaveolens flowers in mice.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Diclofenac; Disease Models, Animal; Drug Eva | 2007 |
Blocking the glial function suppresses subcutaneous formalin-induced nociceptive behavior in the rat.
Topics: Animals; Behavior, Animal; Carbenoxolone; Citrates; Disease Models, Animal; Drug Interactions; Fluor | 2007 |
Effects of intrathecal injection of T-type calcium channel blockers in the rat formalin test.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Disease Models, Animal; Dose-Response R | 2007 |
Effects of traditional "Juci" (contralateral acupuncture) on orofacial nociceptive behavior in the rat.
Topics: Acupuncture Therapy; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Disinf | 2007 |
The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain.
Topics: 3T3 Cells; Analgesics, Opioid; Animals; Antibodies, Monoclonal; Binding Sites, Antibody; Disease Mod | 2007 |
The protective role of testosterone in the development of temporomandibular joint pain.
Topics: Analysis of Variance; Androgens; Animals; Castration; Disease Models, Animal; Dose-Response Relation | 2007 |
The mechanisms of pain-induced pulmonary vasoconstriction: an experimental study in fetal lambs.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Catecholamines; Disease Models, Animal; Fetal | 2007 |
Altered response to formalin by L5 spinal nerve ligation in rats: a behavioral and molecular study.
Topics: Acute Disease; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related | 2007 |
Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals.
Topics: Acetic Acid; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Carrageenan; C | 2006 |
Optimized preservation of CNS morphology for the identification of glycogen in the Pompe mouse model.
Topics: Animals; Brain; Buffers; Cerebellum; Disease Models, Animal; Fixatives; Formaldehyde; Glycogen; Glyc | 2007 |
Diabetes-induced chemogenic hypoalgesia is paralleled by attenuated stimulus-induced fos expression in the spinal cord of diabetic mice.
Topics: Animals; Behavior, Animal; Cell Count; Diabetes Mellitus, Experimental; Disease Models, Animal; Form | 2007 |
Formalin-fixed Staphylococcus aureus particles prevent allergic sensitization in a murine model of type I allergy.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Female; Fixatives; Formaldehyde; Hypersensitivity; | 2007 |
Activation of central 5HT2A receptors reduces the craniofacial nociception of rats.
Topics: Action Potentials; Amphetamines; Animals; Behavior, Animal; Disease Models, Animal; Drug Interaction | 2007 |
Analgesia induced by morphine microinjected into the nucleus raphe magnus: effects on tonic pain.
Topics: Analgesia; Analgesics, Opioid; Animals; Disease Models, Animal; Formaldehyde; Male; Microinjections; | 2007 |
Dopamine D(1) and D(2) receptor agonism enhances antinociception mediated by the serotonin and noradrenaline reuptake inhibitor duloxetine in the rat formalin test.
Topics: Analgesics; Animals; Antidepressive Agents; Disease Models, Animal; Dopamine Agonists; Dose-Response | 2007 |
Effects of honokiol and magnolol on acute and inflammatory pain models in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Central Nervous System Depress | 2007 |
Extended swimming exercise reduces inflammatory and peripheral neuropathic pain in rodents.
Topics: Analysis of Variance; Animals; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; | 2007 |
Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models.
Topics: Animals; Behavior, Animal; CD11b Antigen; Cell Count; Cyclooxygenase 1; Cyclooxygenase 2; Disease Mo | 2007 |
Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model.
Topics: Animals; Disease Models, Animal; Formaldehyde; Male; Neurotensin; Pain; Pain Measurement; Rats; Rats | 2008 |
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Topics: Analgesics; Animals; Brain; Capsaicin; Chronic Disease; Diazepam; Disease Models, Animal; Fluorobenz | 2008 |
MALDI imaging of formalin-fixed paraffin-embedded tissues: application to model animals of Parkinson disease for biomarker hunting.
Topics: Animals; Biomarkers; Chromatography, Liquid; Disease Models, Animal; Formaldehyde; Male; Paraffin Em | 2008 |
The interaction between inhibitors of nitric oxide synthase and cyclooxygenase in formalin-induced pain in mice: an isobolographic study.
Topics: Animals; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 2008 |
Nefopam and ketoprofen synergy in rodent models of antinociception.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, A | 2008 |
Inorganic arsenic exposure affects pain behavior and inflammatory response in rat.
Topics: Animals; Arsenites; Behavior, Animal; Carrageenan; Dinoprostone; Disease Models, Animal; Drug Admini | 2008 |
Dopamine D2-like receptor in the nucleus accumbens is involved in the antinociceptive effect of nitrous oxide.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dopamine Antagonists; Formaldehyde; M | 2008 |
Immunohistology on formol-sublimate fixed and paraplast embedded kidney tissue with comparison to formalin fixation and to pre-embedding immunofluorescent staining.
Topics: Animals; Complement C3; Disease Models, Animal; Female; Fixatives; Fluorescent Antibody Technique; F | 1983 |
Objective evaluation of analgesic effect of drugs in laboratory animals by a new methodological approach.
Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Bradykinin; Disease Models, Animal; Dogs; Drug Eva | 1982 |
The formalin test: a tonic pain model in the primate.
Topics: Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; Female; Formaldehyde; Hand; Maca | 1984 |
[Formalin-induced minor tremor response as an indicator of pain].
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Carrageenan; Disease Models, Animal; Dose-Response Relati | 1984 |
[Role of formalin in the occurrence of sclerosing lesions of the bile ducts. Experimental approach in dogs. Apropos of 3 clinical cases].
Topics: Adult; Aged; Animals; Bile Duct Diseases; Bile Ducts; Disease Models, Animal; Dogs; Echinococcosis, | 1984 |
Preliminary findings on the use of protozoa (Tetrahymena thermophila) as models for ocular irritation testing in rabbits.
Topics: Animals; Disease Models, Animal; Eye; Formaldehyde; Glycerol; Irritants; Rabbits; Tetrahymena | 1983 |
Anti-inflammatory activity of the bark of Hippocratea excelsa.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; | 1995 |
Inflammation of the colonic wall induced by formalin as a model of acute visceral pain.
Topics: Acute Disease; Animals; Colitis; Disease Models, Animal; Female; Formaldehyde; Morphine; Naloxone; P | 1994 |
Total IgE antibody production in BALB/c mice after dermal exposure to chemicals.
Topics: Administration, Cutaneous; Aldehydes; Animals; Dermatitis, Contact; Dinitrochlorobenzene; Disease Mo | 1995 |
A formalin-inactivated vaccine protects against mucosal papillomavirus infection: a canine model.
Topics: Animals; Blotting, Southern; Disease Models, Animal; Dogs; Female; Formaldehyde; Leukocyte L1 Antige | 1994 |
Morphine dependence with or without tolerance in formalin-treated mice: further evidence for the dissociation.
Topics: Analgesia; Animals; Anxiety; Disease Models, Animal; Drug Tolerance; Formaldehyde; Injections, Intra | 1994 |
[Usefulness of the fruit fly for assessment of mutagenicity of benzene, acetaldehyde and formaldehyde].
Topics: Acetaldehyde; Animals; Benzene; Disease Models, Animal; Drosophila melanogaster; Environmental Pollu | 1994 |
Experimental evaluation of the effect of filtration of diesel exhaust by biologic exposure indicators.
Topics: Air Pollutants; Airway Resistance; Animals; Carbon; Catalysis; Disease Models, Animal; Equipment Des | 1995 |
An approach to mechanism-based cancer risk assessment for formaldehyde.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Humans; Neoplasms, | 1993 |
Pentobarbitone, but not propofol, produces pre-emptive analgesia in the rat formalin model.
Topics: Analgesics; Anesthesia, Intravenous; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde | 1994 |
Nude mouse model to study passive humoral immunotherapy directed against B16 F10 murine melanoma.
Topics: Animals; Antibodies, Neoplasm; Disease Models, Animal; Extracellular Space; Formaldehyde; Immunizati | 1994 |
Relationship between ventricular rate and cardiac output in mimic experimental atrial fibrillation.
Topics: Animals; Atrial Fibrillation; Cardiac Output; Cardiac Pacing, Artificial; Disease Models, Animal; Do | 1994 |
Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain.
Topics: Animals; Behavior, Animal; Blood Glucose; Chronic Disease; Diabetes Mellitus, Experimental; Disease | 1993 |
A human respiratory syncytial virus (RSV) primate model of enhanced pulmonary pathology induced with a formalin-inactivated RSV vaccine but not a recombinant FG subunit vaccine.
Topics: Animals; Antibodies, Viral; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Relationship | 1993 |
Streptococcus pneumoniae in the nasal cavity of mice causes lower respiratory tract infection after airway obstruction.
Topics: Airway Obstruction; Ampicillin; Animals; Antibodies, Bacterial; Colony Count, Microbial; Disease Mod | 1996 |
Proposed animal neurosensitization model for multiple chemical sensitivity in studies with formalin.
Topics: Animals; Anxiety; Avoidance Learning; Disease Models, Animal; Female; Formaldehyde; Memory; Models, | 1996 |
Lexipafant (BB-882), a platelet activating factor receptor antagonist, ameliorates mucosal inflammation in an animal model of colitis.
Topics: Animals; Colitis; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Lin | 1996 |
Nonimmunological factors affecting the release of excreted/secreted antigens from Toxoplasma gondii cysts.
Topics: Animals; Antigens, Protozoan; Brain; Disease Models, Animal; Female; Fixatives; Formaldehyde; Mice; | 1996 |
Attenuation of the inflammatory response in an animal colitis model by neutrophil inhibitory factor, a novel beta 2-integrin antagonist.
Topics: Acute Disease; Animals; CD18 Antigens; Colitis; Disease Models, Animal; Eicosanoids; Formaldehyde; G | 1996 |
Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain.
Topics: Analgesics; Animals; Calcium Channel Blockers; Disease Models, Animal; Formaldehyde; Ion Channel Gat | 1996 |
Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Drug Interactions; Formaldehyde; Injec | 1997 |
Absorption kinetics of rectal formalin instillation.
Topics: Administration, Rectal; Animals; Disease Models, Animal; Dogs; Formaldehyde; Intestinal Mucosa; Pilo | 1997 |
Short-term tissue response to potential root-end filling materials in infected root canals.
Topics: Animals; Bacterial Infections; Dental Amalgam; Dental Pulp Cavity; Disease Models, Animal; Dogs; Dru | 1997 |
Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).
Topics: Abdominal Pain; Acetic Acid; Animals; Bradykinin; Capsaicin; Disease Models, Animal; Dose-Response R | 1998 |
Modulation of the formalin-induced nociceptive response by diabetes: possible involvement of protein kinase C.
Topics: Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Disease Models, Animal; Enzyme Activatio | 1998 |
Pre- versus postinjury effects of intravenous GABAergic anesthetics on formalin-induced Fos immunoreactivity in the rat spinal cord.
Topics: Adjuvants, Anesthesia; Analgesics; Analysis of Variance; Anesthetics; Anesthetics, Intravenous; Anim | 1999 |
Possible virulence factors of Staphylococcus aureus in a mouse septic model.
Topics: Animals; Anti-Bacterial Agents; Blood Bactericidal Activity; Cell Survival; Chlorocebus aethiops; Di | 1999 |
A murine model for Down syndrome shows reduced responsiveness to pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Down Syndrome; Escape Reaction; Formaldehyde; Hot | 1999 |
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Anim | 1999 |
Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: a comparative study with the formalin test.
Topics: Animals; Bee Venoms; Disease Models, Animal; Formaldehyde; Hindlimb; Hot Temperature; Hyperalgesia; | 1999 |
Factors affecting the course and severity of transnasally induced Staphylococcus aureus pneumonia in mice.
Topics: Animals; Colony Count, Microbial; Cyclophosphamide; Disease Models, Animal; Disinfectants; Formaldeh | 1999 |
Post-mortem analysis of apoptotic changes associated with human skin bruises.
Topics: Adult; Aged; Aged, 80 and over; Animals; Apoptosis; Cadaver; Cell Count; Cell Death; Confidence Inte | 2000 |
Efficacy of an inactivated vaccine for equine herpesvirus type 1 in a novel hamster model.
Topics: Animals; Animals, Newborn; Antibodies, Viral; Antigens, Viral; Cell Line; Cricetinae; Disease Models | 2000 |
Enhanced pulmonary pathology in cotton rats upon challenge after immunization with inactivated parainfluenza virus 3 vaccines.
Topics: Animals; Disease Models, Animal; Formaldehyde; Humans; Lung; Parainfluenza Vaccines; Parainfluenza V | 2000 |
Respiratory syncytial virus (RSV)-induced airway hyperresponsiveness in allergically sensitized mice is inhibited by live RSV and exacerbated by formalin-inactivated RSV.
Topics: Administration, Intranasal; Animals; Disease Models, Animal; Female; Formaldehyde; Methacholine Chlo | 2000 |
Experimental study on the low-intensity millimeter-wave electro-magnetic stimulation of acupuncture points.
Topics: Acupuncture Points; Animals; Behavior, Animal; Disease Models, Animal; Electroacupuncture; Formaldeh | 2000 |
What is the required reperfusion period for assessment of myocardial infarct size using triphenyltetrazolium chloride staining in the rat?
Topics: Animals; Body Temperature; Coloring Agents; Disease Models, Animal; Female; Formaldehyde; Hemodynami | 2000 |
Cataract in enucleated goat eyes: training model for phacoemulsification.
Topics: Animals; Cataract; Disease Models, Animal; Education, Medical, Continuing; Eye Enucleation; Fixative | 2000 |
Structure-antinociceptive activity studies of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis.
Topics: Alkaloids; Analgesics; Animals; Azabicyclo Compounds; Coumaric Acids; Disease Models, Animal; Formal | 2001 |
Exposure to repeated low-level formaldehyde in rats increases basal corticosterone levels and enhances the corticosterone response to subsequent formaldehyde.
Topics: Animals; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administrati | 2001 |
Chronic bacterial rhinosinusitis: description of a mouse model.
Topics: Animals; Chronic Disease; Disease Models, Animal; Formaldehyde; Hemostatics; Male; Mice; Mice, Inbre | 2001 |
Structure-activity study and analgesic efficacy of amino acid derivatives as N-type calcium channel blockers.
Topics: Amino Acids; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Disease Models | 2001 |
B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice.
Topics: Acetic Acid; Animals; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; | 2001 |
Human potency predictions for aldehydes using the local lymph node assay.
Topics: Aldehydes; Allergens; Animals; Dermatitis, Allergic Contact; Disease Models, Animal; Dose-Response R | 2001 |
Increased replication of respiratory syncytial virus (RSV) in pulmonary infiltrates is associated with enhanced histopathological disease in bonnet monkeys (Macaca radiata) pre-immunized with a formalin-inactivated RSV vaccine.
Topics: Animals; Disease Models, Animal; Formaldehyde; Humans; Inflammation; Lung; Macaca radiata; Respirato | 2001 |
Blocking NMDA receptors in the hippocampal dentate gyrus with AP5 produces analgesia in the formalin pain test.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Behavior, Animal; Dentate Gyrus; Disease Models, An | 2001 |
Vaccine-enhanced respiratory syncytial virus disease in cotton rats following immunization with Lot 100 or a newly prepared reference vaccine.
Topics: Animals; Autopsy; Bronchiolitis; Disease Models, Animal; Female; Formaldehyde; Humans; Lung; Male; P | 2001 |
Cooling decreases fos-immunoreactivity in the rat after formalin injection.
Topics: Animals; Cryotherapy; Culture Techniques; Disease Models, Animal; Edema; Female; Formaldehyde; Genes | 2002 |
Evaluation of Lewis and SHR rat strains as a genetic model for the study of anxiety and pain.
Topics: Animals; Anxiety; Blood Pressure; Disease Models, Animal; Female; Formaldehyde; Lighting; Male; Pain | 2002 |
Passive immunization with convalescent serum, or oral immunization with formalin-killed organisms, does not protect mice against gastrointestinal challenge with Listeria monocytogenes.
Topics: Administration, Oral; Animals; Bacterial Adhesion; Bacterial Vaccines; Colony Count, Microbial; Dige | 2002 |
Nociceptive behaviour induced by dental application of irritants to rat incisors: a new model for tooth inflammatory pain.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Capsaicin; Crowns; Cyclooxygenase Inhibitors; Dental | 2002 |
Comparison of the topical haemostatic agents for the prevention of suture hole bleeding. An experimental study.
Topics: Administration, Topical; Animals; Aorta, Abdominal; Blood Loss, Surgical; Collagen; Disease Models, | 2002 |
[Significance of nitric oxide function in development of cardiac hypertrophy under condition of experimental renal hypertension].
Topics: Animals; Cardiomegaly; Cell Count; Disease Models, Animal; Formaldehyde; Heart; Hypertension, Renal; | 2002 |
[Quantitative histometric investigations on the epidermis and corium of rat paw after experimental inflammation (author's transl)].
Topics: Animals; Biometry; Carrageenan; Disease Models, Animal; Formaldehyde; Freund's Adjuvant; Hyperplasia | 1976 |
[Body temperature changes in formalin- and adjuvant-arthritis in rats (proceedings)].
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Body Temperature; Disease Models, Animal; F | 1976 |
[Studies on the influence of an artifically induced inflammatory reaction by creatinine, urea and guanidine injection (author's transl)].
Topics: Animals; Creatinine; Disease Models, Animal; Drug Antagonism; Drug Interactions; Edema; Formaldehyde | 1975 |
[Experimental sclerosing cholangitis following intrabiliary injection of formol in the rat].
Topics: Animals; Biliary Tract; Cholangiography; Cholangitis, Sclerosing; Disease Models, Animal; Echinococc | 1992 |
Erythrocytes with covalently bound fibrinogen as a cellular replacement for the treatment of thrombocytopenia.
Topics: Animals; Autoimmune Diseases; Blood Transfusion, Autologous; Cross-Linking Reagents; Disease Models, | 1992 |
Formalin nociception in the mouse does not lead to increased spinal serotonin turnover.
Topics: Animals; Disease Models, Animal; Formaldehyde; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred IC | 1990 |
Neurogenic component of different models of acute inflammation in the rat knee joint.
Topics: Animals; Capsaicin; Carrageenan; Disease Models, Animal; Formaldehyde; Hindlimb; Inflammation; Joint | 1991 |
Freezing lesions of the developing rat brain: a model for cerebrocortical microgyria.
Topics: Animals; Animals, Newborn; Brain; Cerebral Cortex; Disease Models, Animal; Formaldehyde; Freezing; H | 1991 |
A formalin inactivated whole SIV vaccine and a glycoprotein-enriched subunit vaccine confers protection against experimental challenge with pathogenic live SIV in rhesus monkeys.
Topics: Animals; Antibodies, Viral; Chromatography, Affinity; Cryopreservation; Disease Models, Animal; Form | 1990 |
Sclerosing cholangitis induced by formaldehyde solution injected into the biliary tree of rats.
Topics: Animals; Cholangitis, Sclerosing; Common Bile Duct; Disease Models, Animal; Duodenum; Echinococcosis | 1990 |
A formalin-inactivated whole SIV vaccine confers protection in macaques.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Alum Compounds; Animals; Antibodies, Vira | 1989 |
Epidemiology and experimental toxicology--is there a meeting ground? Discussion paper.
Topics: Animals; Dioxins; Disease Models, Animal; Epidemiology; Formaldehyde; Humans; Nickel; Predictive Val | 1989 |
Methodological refinements to the mouse paw formalin test. An animal model of tonic pain.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphin | 1988 |
[Investigation of papillary insufficiency in dogs by monitoring the manometry of the biliary tract with the saline perfusion method].
Topics: Ampulla of Vater; Animals; Common Bile Duct; Dilatation, Pathologic; Disease Models, Animal; Dogs; F | 1988 |
[Studies of inflammatory pain response: related pain producing substance and endogenous opioid system].
Topics: Analgesics; Animals; Disease Models, Animal; Endorphins; Formaldehyde; Inflammation; Male; Mice; Mic | 1986 |
Preliminary studies on the use of ferritin-conjugated antibodies to Plasmodium berghei.
Topics: Aldehydes; Animals; Antibody Formation; Bone Marrow; Bone Marrow Cells; Cell Membrane Permeability; | 1971 |
[Studies on the mechanism of the therapeutic and toxic action of the horse chestnut saponin aescin].
Topics: Animals; Arthritis; Arthus Reaction; Bradykinin; Capillary Permeability; Carrageenan; Depression, Ch | 1970 |
Production of cardiac hypertrophy and failure in rabbits with Ameroid clips.
Topics: Animals; Aorta, Thoracic; Aortic Diseases; Cardiomegaly; Caseins; Disease Models, Animal; Formaldehy | 1970 |
[Efficacy of different antiphlogistic agents with respect to carrageenan-inflammation, compared with other models of inflammation].
Topics: Adrenocorticotropic Hormone; Aminopyrine; Animals; Anti-Inflammatory Agents; Aspirin; Carrageenan; D | 1971 |
[Quantitative histometric investigations on paw edema induced by carrageenin, formalin and aerosil in rats (author's transl)].
Topics: Animals; Biometry; Carrageenan; Disease Models, Animal; Edema; Formaldehyde; Hindlimb; Histological | 1974 |
[A simple method of producing neovascularisation and membranes in the vitreous cavity of the rabbit (author's transl)].
Topics: Animals; Blood Vessels; Disease Models, Animal; Eye Diseases; Formaldehyde; Injections; Methods; Rab | 1974 |
Effect of age on development of cor pulmonale in nonhuman primates following pyrrolizidine alkaloid intoxication.
Topics: Age Factors; Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Enzymes; Femal | 1972 |
[Use of a model of fatty dystrophy of the liver in a sanitary-toxicological experiment].
Topics: Animals; Chemical and Drug Induced Liver Injury; Disease Models, Animal; Formaldehyde; Lipodystrophy | 1972 |
Immunity to influenza in ferrets. VI. Immunization with adjuvanted vaccines.
Topics: Adjuvants, Immunologic; Aluminum Hydroxide; Animals; Antibodies, Viral; Antibody Formation; Body Tem | 1973 |
Discrimination between binding to CNS, toxicity and immunreactivity of derivatives of tetanus toxin.
Topics: Acetylation; Animals; Autoradiography; Binding Sites; Binding Sites, Antibody; Brain; Chloramines; D | 1973 |
Preparation of inactivated vaccines against alphaviruses using Semliki Forest virus-white mouse as a model. I. Inactivation experiments and evaluation of double inactivated subunit vaccines.
Topics: Adjuvants, Immunologic; Animals; Arbovirus Infections; Azirines; Chick Embryo; Culture Techniques; D | 1973 |
Preparation of inactivated vaccines against alphaviruses using Semliki Forest virus-white mouse as a model. II. Evaluation of formalin-inactivated vaccines treated with tri(n-butyl)phosphate and-or saponin and properties of the inactivated virus.
Topics: Amino Acids; Animals; Arbovirus Infections; Carbon Radioisotopes; Centrifugation, Density Gradient; | 1973 |
BSA-induced allergic arthritis and formol-induced non-allergic arthritis in rabbits. 1. Comparative studies on morphological features and course of the disease.
Topics: Animals; Arthritis; Disease Models, Animal; Female; Fibrin; Formaldehyde; Histiocytes; Inflammation; | 1973 |
[Wound healing process during application of anabolic and catabolic steroids in the rabbit ear model according to Heite].
Topics: Administration, Topical; Anabolic Agents; Analysis of Variance; Androstenols; Animals; Anti-Inflamma | 1973 |
Bacteriology and pathological study of leprous lesions in the footpads of mice.
Topics: Animals; Bacteriological Techniques; Disease Models, Animal; Formaldehyde; Hindlimb; Histological Te | 1970 |
[The experimentally irritaded bladder].
Topics: Animals; Cats; Disease Models, Animal; Female; Formaldehyde; Male; Urinary Bladder Diseases; Urinary | 1972 |
[A comparative study on various antiphlogistics].
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Asbestos; Dextrans; Disease Models, Animal; Dr | 1971 |
The influence of structurally related sympathomimetic amines on ocular dynamics.
Topics: Animals; Aqueous Humor; Disease Models, Animal; Epinephrine; Eye; Formaldehyde; Injections; Intraocu | 1971 |
[Use of animal disease models in studies on hygienic standardization].
Topics: Air Pollution; Animals; Castration; Disease Models, Animal; Environmental Health; Formaldehyde; Maxi | 1970 |