formaldehyde has been researched along with Diabetic Neuropathies in 14 studies
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy
Diabetic Neuropathies: Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We evaluated the effects of zonisamide on inflammatory and neuropathic pain using the mouse formalin test and streptozotocin (STZ)-induced diabetic mice with a reduced withdrawal threshold to mechanical stimuli, respectively." | 7.74 | Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy. ( Murakami, T; Ono, H; Tanabe, M, 2008) |
| "An excess of excitatory pathway activation via N-methyl-D-aspartate (NMDA) receptors has been described in neuropathic pain that responds poorly to morphine." | 7.71 | Magnesium increases morphine analgesic effect in different experimental models of pain. ( Begon, S; Dubray, C; Eschalier, A; Pickering, G, 2002) |
| " Chronic administration of minocycline (40 and 80 mg/kg, i." | 5.37 | Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms. ( Dua, K; Kulkarni, SK; Pabreja, K; Padi, SS; Sharma, S, 2011) |
| "Rats developed tactile allodynia within days of the onset of diabetes and which persisted for up to 8 weeks." | 5.29 | Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. ( Calcutt, NA; Chaplan, SR; Jorge, MC; Yaksh, TL, 1996) |
| "We evaluated the effects of zonisamide on inflammatory and neuropathic pain using the mouse formalin test and streptozotocin (STZ)-induced diabetic mice with a reduced withdrawal threshold to mechanical stimuli, respectively." | 3.74 | Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy. ( Murakami, T; Ono, H; Tanabe, M, 2008) |
| "An excess of excitatory pathway activation via N-methyl-D-aspartate (NMDA) receptors has been described in neuropathic pain that responds poorly to morphine." | 3.71 | Magnesium increases morphine analgesic effect in different experimental models of pain. ( Begon, S; Dubray, C; Eschalier, A; Pickering, G, 2002) |
| "Ifenprodil was administered in PDN rats while saline was administered intrathecally in the control group." | 1.62 | Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats. ( Ab Aziz, CB; Ismail, CAN; Long, I; Suppian, R, 2021) |
| "The complications of diabetic polyneuropathy (DN) determines its level of severity." | 1.56 | Expressions of spinal microglia activation, BDNF, and DREAM proteins correlated with formalin-induced nociceptive responses in painful and painless diabetic neuropathy rats. ( Ab Aziz, CB; Ismail, CAN; Long, I; Suppian, R, 2020) |
| " Chronic administration of minocycline (40 and 80 mg/kg, i." | 1.37 | Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms. ( Dua, K; Kulkarni, SK; Pabreja, K; Padi, SS; Sharma, S, 2011) |
| "Rats developed tactile allodynia within days of the onset of diabetes and which persisted for up to 8 weeks." | 1.29 | Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. ( Calcutt, NA; Chaplan, SR; Jorge, MC; Yaksh, TL, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 5 (35.71) | 24.3611 |
| 2020's | 3 (21.43) | 2.80 |
| Authors | Studies |
|---|---|
| Ismail, CAN | 3 |
| Ghazali, AK | 1 |
| Suppian, R | 3 |
| Abd Aziz, CB | 1 |
| Long, I | 3 |
| Ab Aziz, CB | 2 |
| Sałat, K | 1 |
| Kołaczkowski, M | 1 |
| Furgała, A | 1 |
| Rojek, A | 1 |
| Śniecikowska, J | 1 |
| Varney, MA | 1 |
| Newman-Tancredi, A | 1 |
| Silva, M | 1 |
| Martins, D | 1 |
| Charrua, A | 1 |
| Piscitelli, F | 1 |
| Tavares, I | 1 |
| Morgado, C | 1 |
| Di Marzo, V | 1 |
| Huang, YH | 1 |
| Hou, SY | 1 |
| Cheng, JK | 1 |
| Wu, CH | 1 |
| Lin, CR | 1 |
| Tanabe, M | 1 |
| Murakami, T | 1 |
| Ono, H | 1 |
| Jolivalt, CG | 1 |
| Mizisin, LM | 1 |
| Nelson, A | 1 |
| Cunha, JM | 2 |
| Ramos, KM | 1 |
| Bonke, D | 1 |
| Calcutt, NA | 2 |
| Pabreja, K | 1 |
| Dua, K | 1 |
| Sharma, S | 1 |
| Padi, SS | 1 |
| Kulkarni, SK | 1 |
| Schreiber, AK | 1 |
| Neufeld, M | 1 |
| Jesus, CH | 1 |
| Christianson, JA | 1 |
| Ryals, JM | 1 |
| McCarson, KE | 1 |
| Wright, DE | 1 |
| Jorge, MC | 1 |
| Yaksh, TL | 1 |
| Chaplan, SR | 1 |
| Kamei, J | 1 |
| Taki, K | 1 |
| Ohsawa, M | 1 |
| Hitosugi, H | 1 |
| Begon, S | 1 |
| Pickering, G | 1 |
| Eschalier, A | 1 |
| Dubray, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Magnesium Oral Supplementation to Reduce Pain in Patients With Severe Peripheral Arterial Occlusive Disease: The MAG-PAPER Randomized Clinical Trial[NCT02455726] | 150 participants (Anticipated) | Interventional | 2015-09-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 other studies available for formaldehyde and Diabetic Neuropathies
| Article | Year |
|---|---|
Lower Formalin-Induced Pain Responses in Painless Diabetic Neuropathy Rat Correlate with the Reduced Spinal Cord NR2B Subunit of N-Methyl-D-Aspartate Receptor Activation.
Topics: Animals; Diabetes Mellitus; Diabetic Neuropathies; Formaldehyde; Male; Pain; Rats; Rats, Sprague-Daw | 2022 |
Expressions of spinal microglia activation, BDNF, and DREAM proteins correlated with formalin-induced nociceptive responses in painful and painless diabetic neuropathy rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Diabetes Mellitus; Diabetic Neuropathies; Formaldehyde; | 2020 |
Ifenprodil Reduced Expression of Activated Microglia, BDNF and DREAM Proteins in the Spinal Cord Following Formalin Injection During the Early Stage of Painful Diabetic Neuropathy in Rats.
Topics: Animals; Brain-Derived Neurotrophic Factor; Diabetic Neuropathies; Formaldehyde; Kv Channel-Interact | 2021 |
Antinociceptive, antiallodynic and antihyperalgesic effects of the 5-HT
Topics: Analgesics; Animals; Antineoplastic Agents; Cyclohexanes; Diabetic Neuropathies; Disease Models, Ani | 2017 |
Endovanilloid control of pain modulation by the rostroventromedial medulla in an animal model of diabetic neuropathy.
Topics: Amides; Amidohydrolases; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Capsaicin; Chronic Pa | 2016 |
Pulsed radiofrequency attenuates diabetic neuropathic pain and suppresses formalin-evoked spinal glutamate release in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Formaldehyde; Glutamic Acid; Male; | 2016 |
Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Formaldehyde; Inflammation; Isoxazo | 2008 |
B vitamins alleviate indices of neuropathic pain in diabetic rats.
Topics: Aldehydes; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Dose-Resp | 2009 |
Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Biomarkers; Blood Glucose; Body W | 2011 |
Peripheral antinociceptive effect of anandamide and drugs that affect the endocannabinoid system on the formalin test in normal and streptozotocin-diabetic rats.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Capsaicin; Diabetes Mellitus, Experimental | 2012 |
Beneficial actions of neurotrophin treatment on diabetes-induced hypoalgesia in mice.
Topics: Animals; Behavior, Animal; Blood Glucose; Body Weight; Cold Temperature; Diabetes Mellitus, Experime | 2003 |
Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine.
Topics: Aldehyde Reductase; Anesthetics, Local; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dia | 1996 |
Modulation of the formalin-induced nociceptive response by diabetes: possible involvement of intracellular calcium.
Topics: Animals; Calcium; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disinfectants; Enzyme Inhi | 2000 |
Magnesium increases morphine analgesic effect in different experimental models of pain.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Synergism; | 2002 |