Page last updated: 2024-10-18

formaldehyde and Cancer of Nose

formaldehyde has been researched along with Cancer of Nose in 81 studies

paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy

Research Excerpts

ExcerptRelevanceReference
"Formaldehyde is a well known nasal carcinogen in rodents, but so far there has been no convincing evidence that workers occupationally exposed to formaldehyde have an increased risk of nasal cancer."5.28Malignant melanomas of the nasal cavity after occupational exposure to formaldehyde. ( Holmstrom, M; Lund, VJ, 1991)
" Examples for nasal tumor induction by formaldehyde and for the induction of renal adenocarcinoma by ochratoxin A are shown."3.71Statistical procedures to test for linearity and estimate threshold doses for tumor induction with nonlinear dose-response relationships in bioassays for carcinogenicity. ( Lutz, RW; Lutz, WK; Stahel, WA, 2002)
"Thus, prevention of nasal cancer is considered to prevent lymphohematopoietic malignancies."2.46Cancer effects of formaldehyde: a proposal for an indoor air guideline value. ( Nielsen, GD; Wolkoff, P, 2010)
"Three types of cancer were assessed: nasopharyngeal cancer, leukemia and sinonasal cancer."2.44[Assessment of carcinogenicity of formaldehyde based on the newest literature data]. ( Kupczewska-Dobecka, M, 2007)
"Molecular genetic studies on nasal squamous cell carcinomas (SCC) in rats thus far have indicated the presence of oncogenes unrelated to the ras oncogene family and that p53 mutation occurs at a high frequency among the nasal SCC examined."2.40Oncogene and tumor suppressor gene alterations in nasal tumors. ( Recio, L, 1997)
"Sulfuric acid appears to cause laryngeal cancer."2.40Reactive chemicals and cancer. ( Blair, A; Kazerouni, N, 1997)
"Formaldehyde is a nasal carcinogen in the rat but the cancer risk this chemical poses for humans remains to be determined."2.39Cell proliferation and formaldehyde-induced respiratory carcinogenesis. ( Monticello, TM; Morgan, KT, 1994)
" Dose-response data from human exposure situations would provide the most solid foundation for risk assessment, avoiding problematic extrapolations from the health effects seen in nonhuman species."2.38Quantitative cancer risk estimation for formaldehyde. ( Starr, TB, 1990)
"Formaldehyde was recently shown to be carcinogenic in the nasal cavities of rats and mice following chronic inhalation at vapor concentrations which were cytotoxic."2.37An analysis of potential carcinogenic risk from formaldehyde. ( Cameron, LL; Squire, RA, 1984)
" These values are presented as a best estimate envelope obtained from five mathematical dose-response formulation."2.37Risk assessment of laboratory rats and mice chronically exposed to formaldehyde vapors. ( Brown, KG, 1985)
" Dose-response predictions below the range of exposures where tumors occurred in the bioassays were highly sensitive to the choice of control data."1.34Uncertainties in the CIIT model for formaldehyde-induced carcinogenicity in the rat: a limited sensitivity analysis-I. ( Chen, C; Crump, KS; Schlosser, PM; Subramaniam, RP; Van Landingham, C; White, P, 2007)
" Two methods for dose-response assessment were used: a full biologically based modeling approach and a statistically oriented analysis by benchmark dose (BMD) method."1.32Benchmark dose risk assessment for formaldehyde using airflow modeling and a single-compartment, DNA-protein cross-link dosimetry model to estimate human equivalent doses. ( Conolly, RB; Janszen, DB; Kimbell, JS; Lilly, PD; Schlosser, PM, 2003)
" The direct mutagenicity mode of action was represented by a low dose linear dose-response model of DNA-protein cross-link (DPX) formation."1.32Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat. ( Conolly, RB; Janszen, D; Kalisak, D; Kimbell, JS; Miller, FJ; Preston, J; Schlosser, PM, 2003)
" 75, 432-447, 2003) analyzed the rat tumor dose-response assuming that both DNA-reactive and cytotoxic effects of formaldehyde contribute to SCC development."1.32Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset. ( Conolly, RB; Janszen, D; Kalisak, D; Kimbell, JS; Miller, FJ; Preston, J; Schlosser, PM, 2004)
"Formaldehyde (FA) is a mutagen that, at high concentrations and long durations, has been reported to cause nasal cancer in rats and in some humans."1.32Formaldehyde-induced DNA adducts as biomarkers of in vitro human nasal epithelial cell exposure to formaldehyde. ( Que Hee, SS; Zhong, W, 2004)
"Elevated rates of nasal and nasopharyngeal cancers have been associated with wood-related occupational exposures, including chlorophenols, formaldehyde, and wood dust."1.31Occupational exposure to chlorophenol and the risk of nasal and nasopharyngeal cancers among U.S. men aged 30 to 60. ( Brann, EA; Gnepp, DR; Herrick, RF; Hoppin, JA; Mirabelli, MC; Tolbert, PE, 2000)
"For sino-nasal cancer, a relative risk of 3."1.29Formaldehyde and cancer morbidity among male employees in Denmark. ( Hansen, J; Olsen, JH, 1995)
"A case-control study of cancer of the nose and paranasal sinuses was conducted in France to determine whether occupational exposure to formaldehyde was associated with an increased risk of sinonasal cancer."1.29Sinonasal cancer and occupational exposure to formaldehyde and other substances. ( Brugère, J; Gérin, M; Goldberg, M; Leclerc, A; Luce, D; Morcet, JF, 1993)
"Formaldehyde (FA) is a widely produced industrial chemical."1.29DNA--protein crosslinks, a biomarker of exposure to formaldehyde--in vitro and in vivo studies. ( Bomstein, Y; Kaufman, Z; Meltzer, A; Palma, E; Ribak, J; Shaham, J, 1996)
"Formaldehyde induces squamous cell carcinomas in the nasal passages of rats following chronic inhalation exposure at concentrations of > or = 10 ppm."1.28p53 mutations in formaldehyde-induced nasal squamous cell carcinomas in rats. ( Bermudez, E; Chen, Z; Gross, EA; Morgan, K; Pluta, L; Recio, L; Sisk, S; Walker, C, 1992)
"Formaldehyde is a well known nasal carcinogen in rodents, but so far there has been no convincing evidence that workers occupationally exposed to formaldehyde have an increased risk of nasal cancer."1.28Malignant melanomas of the nasal cavity after occupational exposure to formaldehyde. ( Holmstrom, M; Lund, VJ, 1991)
"No deaths from nasal cancer were reported (1."1.27Formaldehyde in the British chemical industry. An occupational cohort study. ( Acheson, ED; Barnes, HR; Gardner, MJ; Osmond, C; Pannett, B; Taylor, CP, 1984)
"The excess risk of sino-nasal cancer with exposure to paint, lacquer and glue remained statistically elevated after adjustment for contemporary exposure to wood-dust and formaldehyde."1.27Occupational formaldehyde exposure and increased nasal cancer risk in man. ( Breum, NO; Faurbo, K; Hink, M; Jensen, OM; Jensen, SP; Olsen, JH, 1984)
"A case of squamous cell carcinoma of the nasal cavity occurred in a 57-year-old man who had 25 years of occupational exposure to low concentrations of formaldehyde in the textile-finishing industry."1.27Nasal cancer in a worker exposed to formaldehyde. ( Elliott, LJ; Goodman, M; Halperin, WE; Keenlyside, RA; Landrigan, PJ; Stayner, L, 1983)
"Formaldehyde inhalation was also weakly associated with an increase in the frequency of polypoid adenomas in the nasal cavity of male rats."1.27Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure. ( Donofrio, DJ; Gralla, EJ; Kerns, WD; Pavkov, KL; Swenberg, JA, 1983)
"Recent animal studies found nasal cancer among rats exposed to formaldehyde, but no excess of this tumor occurred in this study."1.27Mortality among industrial workers exposed to formaldehyde. ( Bales, R; Blair, A; Cubit, D; Gaffey, W; Kaplan, S; O'Berg, M; Stewart, P; Walrath, J; Ward, J, 1986)
"Population-based rates for sinonasal cancer are examined in US mortality data among whites and in Connecticut incidence data."1.27Time and age trends for sinonasal cancer in Connecticut incidence and US mortality rates. ( Holford, TR; Roush, GC; Schymura, MJ; Stevenson, JM, 1987)
"The majority of squamous cell carcinomas occurred on the anterior portion of the lateral aspect of the nasoturbinate and adjacent lateral wall (57%) or the midventral nasal septum (26%)."1.27More precise localization of nasal tumors associated with chronic exposure of F-344 rats to formaldehyde gas. ( Jiang, XZ; Kerns, WD; Morgan, KT; Starr, TB, 1986)
"By Assessment A the relative risk for nasal cancer associated with possible formaldehyde exposure was 2."1.27Cancer of the nasal cavity and paranasal sinuses, and formaldehyde exposure. ( de Bruyn, A; Gerin, M; Hayes, RB; Raatgever, JW, 1986)
"The results from employing metabolized dose in the case of vinyl chloride demonstrate that the delivered dose concept can radically alter the shape of the dose-response curve in the observable response range."1.27The role of mechanistic data in dose-response modeling. ( Starr, TB, 1985)
"Inhalation of formaldehyde causes cancer of the nose in rats."1.26Report of the Federal Panel on Formaldehyde. ( , 1982)

Research

Studies (81)

TimeframeStudies, this research(%)All Research%
pre-199042 (51.85)18.7374
1990's23 (28.40)18.2507
2000's11 (13.58)29.6817
2010's4 (4.94)24.3611
2020's1 (1.23)2.80

Authors

AuthorsStudies
Thompson, CM1
Gentry, R1
Fitch, S1
Lu, K2
Clewell, HJ2
Crump, KS2
Chen, C2
Fox, JF1
Van Landingham, C2
Subramaniam, R1
Flohr, C1
Lee, KK1
Varma, S1
Collins, LB1
Ru, H1
Bermudez, E4
Swenberg, JA4
Yang, Y1
Allen, BC1
Tan, YM1
Liao, KH1
Nielsen, GD1
Wolkoff, P1
Lutz, RW1
Stahel, WA1
Lutz, WK1
Schlosser, PM4
Lilly, PD1
Conolly, RB3
Janszen, DB1
Kimbell, JS4
Janszen, D2
Kalisak, D2
Preston, J2
Miller, FJ2
Zhong, W1
Que Hee, SS1
Meek, ME1
Arts, JH1
Rennen, MA1
de Heer, C1
Subramaniam, RP1
White, P1
Kupczewska-Dobecka, M1
Jensen, OM2
Acheson, ED3
Barnes, HR2
Gardner, MJ3
Osmond, C2
Pannett, B3
Taylor, CP2
Casanova-Schmitz, M1
Starr, TB6
Heck, HD2
Squire, RA1
Cameron, LL1
Koenig, JQ1
Pierson, WE1
L'Abbé, KA1
Hoey, JR1
Ballenger, JJ1
Olsen, JH3
Jensen, SP1
Hink, M1
Faurbo, K1
Breum, NO1
Frazier, TM1
Lalich, NR1
Pedersen, DH1
Kreiger, N1
Halperin, WE1
Goodman, M1
Stayner, L1
Elliott, LJ1
Keenlyside, RA1
Landrigan, PJ1
Kerns, WD3
Pavkov, KL2
Donofrio, DJ1
Gralla, EJ3
Albert, RE1
Sellakumar, AR1
Laskin, S1
Kuschner, M1
Nelson, N1
Snyder, CA1
Swenberg, J1
Kerns, W1
Pavkov, K1
Mitchell, R1
Mitchell, RI1
Wilbourn, J1
Heseltine, E1
Møller, H1
Hansen, J1
Wolf, DC1
Gross, EA5
Lyght, O1
Recio, L4
Morgan, KT6
McMillan, A1
Whittemore, AS1
Silvers, A1
DiCiccio, Y1
Monticello, TM3
Luce, D2
Gérin, M3
Berrino, F1
Pisani, P1
Leclerc, A2
Chen, Z2
Walker, CL1
Pluta, L2
Goldoft, M1
Weiss, N1
Vaughan, T1
Lee, J1
Winter, PD1
Cruddas, AM1
Morcet, JF1
Brugère, J1
Goldberg, M1
Shaham, J1
Bomstein, Y1
Meltzer, A1
Kaufman, Z1
Palma, E1
Ribak, J1
Leininger, JR1
Seilkop, S1
Gibson, JE2
Reed, C1
Kamata, E1
Nakadate, M1
Uchida, O1
Ogawa, Y1
Suzuki, S1
Kaneko, T1
Saito, M1
Kurokawa, Y1
Blair, A4
Kazerouni, N1
Mirabelli, MC1
Hoppin, JA1
Tolbert, PE1
Herrick, RF1
Gnepp, DR1
Brann, EA1
Judge, DM1
McGavran, MH1
Trapukdi, S1
Sisk, S1
Morgan, K1
Walker, C1
Holmstrom, M1
Lund, VJ1
Fellbaum, C1
Hansmann, ML1
Saracci, R1
Stewart, PA1
Hayes, RB2
Shy, C1
Boysen, M1
Zadig, E1
Digernes, V1
Abeler, V1
Reith, A1
Woutersen, RA2
van Garderen-Hoetmer, A2
Bruijntjes, JP1
Zwart, A1
Feron, VJ2
Brandwein, M1
Pervez, N1
Biller, H1
Stewart, P1
O'Berg, M1
Gaffey, W1
Walrath, J2
Ward, J1
Bales, R1
Kaplan, S1
Cubit, D1
Roush, GC2
Stayner, LT1
Kaplan, SA1
Flannery, JT1
Norman, GR1
Newhouse, MT1
Schymura, MJ1
Stevenson, JM1
Holford, TR1
Edling, C2
Hellquist, H2
Odkvist, L2
Lam, CW1
Casanova, M1
Zielhuis, RL1
Krimsky, MM1
Appelman, LM1
Asnaes, S1
Casteel, SW1
Vernon, RJ1
Bailey, EM1
Rosskamp, E1
Stankevich, KI1
Dyshinevich, NE1
Brown, KG1
Jiang, XZ1
Raatgever, JW1
de Bruyn, A1
Gardner, RJ1
Burgess, BA1
Kennedy, GL1
Flamm, WG1
Frankos, V1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Environmental and Genetic Determinants of NPC[NCT01257100]3,500 participants (Actual)Observational2010-12-08Terminated (stopped due to Determined not to be Human Subject Research)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

18 reviews available for formaldehyde and Cancer of Nose

ArticleYear
An updated mode of action and human relevance framework evaluation for Formaldehyde-Related nasal tumors.
    Critical reviews in toxicology, 2020, Volume: 50, Issue:10

    Topics: Animals; Carcinogens; DNA Adducts; DNA Damage; Formaldehyde; Humans; Nose Neoplasms; Rats; Risk Asse

2020
Cancer effects of formaldehyde: a proposal for an indoor air guideline value.
    Archives of toxicology, 2010, Volume: 84, Issue:6

    Topics: Air Pollution, Indoor; Animals; Carcinogens; Dose-Response Relationship, Drug; Environmental Exposur

2010
Inhaled formaldehyde: evaluation of sensory irritation in relation to carcinogenicity.
    Regulatory toxicology and pharmacology : RTP, 2006, Volume: 44, Issue:2

    Topics: Administration, Inhalation; Air Pollutants; Animals; Carcinogens; Carcinoma; Eye; Formaldehyde; Huma

2006
[Assessment of carcinogenicity of formaldehyde based on the newest literature data].
    Medycyna pracy, 2007, Volume: 58, Issue:6

    Topics: Air Pollutants; Animals; Carcinogenicity Tests; Carcinogens; European Union; Formaldehyde; Humans; I

2007
An analysis of potential carcinogenic risk from formaldehyde.
    Regulatory toxicology and pharmacology : RTP, 1984, Volume: 4, Issue:2

    Topics: Aerosols; Animals; Biological Assay; Carcinogens, Environmental; Epidemiologic Methods; Formaldehyde

1984
Nasal responses to air pollutants.
    Clinical reviews in allergy, 1984, Volume: 2, Issue:3

    Topics: Air Pollutants; Air Pollutants, Occupational; Airway Resistance; Chromates; Cilia; Formaldehyde; Hum

1984
Review of the health effects of urea-formaldehyde foam insulation.
    Environmental research, 1984, Volume: 35, Issue:1

    Topics: Abnormalities, Drug-Induced; Adult; Air Pollutants; Animals; Construction Materials; Dermatitis, Con

1984
Cell proliferation and nasal carcinogenesis.
    Environmental health perspectives, 1993, Volume: 101 Suppl 5

    Topics: Animals; Carcinogens; Cell Division; DNA; Formaldehyde; Humans; Kinetics; Nasal Cavity; Nitrosamines

1993
Cell proliferation and formaldehyde-induced respiratory carcinogenesis.
    Risk analysis : an official publication of the Society for Risk Analysis, 1994, Volume: 14, Issue:3

    Topics: Animals; Cell Division; Dose-Response Relationship, Drug; Formaldehyde; Male; Nose; Nose Neoplasms;

1994
Oncogene and tumor suppressor gene alterations in nasal tumors.
    Mutation research, 1997, Oct-31, Volume: 380, Issue:1-2

    Topics: Animals; Carcinoma, Squamous Cell; Formaldehyde; Genes, p53; Genes, Tumor Suppressor; Mutation; Nose

1997
Reactive chemicals and cancer.
    Cancer causes & control : CCC, 1997, Volume: 8, Issue:3

    Topics: Acrylonitrile; Air Pollutants; Animals; Bis(Chloromethyl) Ether; Butadienes; Carcinogens; Cohort Stu

1997
Quantitative cancer risk estimation for formaldehyde.
    Risk analysis : an official publication of the Society for Risk Analysis, 1990, Volume: 10, Issue:1

    Topics: Air Pollutants; Animals; Dose-Response Relationship, Drug; Epidemiologic Factors; Formaldehyde; Huma

1990
Epidemiologic evidence on the relationship between formaldehyde exposure and cancer.
    Scandinavian journal of work, environment & health, 1990, Volume: 16, Issue:6

    Topics: Brain Neoplasms; Colorectal Neoplasms; Environmental Exposure; Formaldehyde; Humans; Leukemia; Lung

1990
Nasal squamous carcinoma in an undertaker--does formaldehyde play a role?
    Rhinology, 1987, Volume: 25, Issue:4

    Topics: Carcinoma, Squamous Cell; Embalming; Formaldehyde; Humans; Male; Middle Aged; Nose Neoplasms; Occupa

1987
Health effects of urea formaldehyde foam insulation: evidence of causation.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1986, Apr-01, Volume: 134, Issue:7

    Topics: Air Pollutants; Formaldehyde; Housing; Humans; Nose Neoplasms; Respiratory Tract Diseases; Urea

1986
The mechanistic toxicology of formaldehyde and its implications for quantitative risk estimation.
    Annual review of pharmacology and toxicology, 1985, Volume: 25

    Topics: Air Pollutants; Animals; Cell Division; Formaldehyde; Humans; Irritants; Mice; Mucous Membrane; Nose

1985
[Hygienic aspects of using wood-shaving boards in the construction of residential and commercial buildings].
    Gigiena i sanitariia, 1985, Issue:11

    Topics: Adenocarcinoma; Air Pollutants; Air Pollution; Allergens; Animals; Construction Materials; Europe; F

1985
Risk assessment of laboratory rats and mice chronically exposed to formaldehyde vapors.
    Risk analysis : an official publication of the Society for Risk Analysis, 1985, Volume: 5, Issue:3

    Topics: Animals; Carcinoma, Squamous Cell; Female; Formaldehyde; Male; Mice; Nasal Cavity; Nose Neoplasms; R

1985

Other Studies

63 other studies available for formaldehyde and Cancer of Nose

ArticleYear
Sensitivity analysis of biologically motivated model for formaldehyde-induced respiratory cancer in humans.
    The Annals of occupational hygiene, 2008, Volume: 52, Issue:6

    Topics: Animals; Cell Transformation, Neoplastic; Disease Models, Animal; Formaldehyde; Humans; Models, Biol

2008
Merocel nasal packing with airway: a method to help secure full-thickness skin grafts on the nasal tip.
    The British journal of dermatology, 2010, Volume: 162, Issue:1

    Topics: Formaldehyde; Humans; Nasal Obstruction; Nose; Nose Neoplasms; Polyvinyl Alcohol; Rhinoplasty; Skin

2010
Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 116, Issue:2

    Topics: Animals; Chromatography, High Pressure Liquid; DNA Adducts; Formaldehyde; Inhalation Exposure; Leuke

2010
Bayesian analysis of a rat formaldehyde DNA-protein cross-link model.
    Journal of toxicology and environmental health. Part A, 2010, Volume: 73, Issue:12

    Topics: Animals; Bayes Theorem; Cross-Linking Reagents; Disease Models, Animal; DNA; DNA Damage; Formaldehyd

2010
Statistical procedures to test for linearity and estimate threshold doses for tumor induction with nonlinear dose-response relationships in bioassays for carcinogenicity.
    Regulatory toxicology and pharmacology : RTP, 2002, Volume: 36, Issue:3

    Topics: Adenocarcinoma; Animals; Biological Assay; Carcinogenicity Tests; Carcinogens; Disinfectants; Dose-R

2002
Benchmark dose risk assessment for formaldehyde using airflow modeling and a single-compartment, DNA-protein cross-link dosimetry model to estimate human equivalent doses.
    Risk analysis : an official publication of the Society for Risk Analysis, 2003, Volume: 23, Issue:3

    Topics: Administration, Inhalation; Air Pollutants; Animals; Carcinoma, Squamous Cell; Cross-Linking Reagent

2003
Biologically motivated computational modeling of formaldehyde carcinogenicity in the F344 rat.
    Toxicological sciences : an official journal of the Society of Toxicology, 2003, Volume: 75, Issue:2

    Topics: Administration, Inhalation; Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Computati

2003
Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 82, Issue:1

    Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Computational Biology; Dose-Response Relationship, D

2004
Formaldehyde-induced DNA adducts as biomarkers of in vitro human nasal epithelial cell exposure to formaldehyde.
    Mutation research, 2004, Sep-12, Volume: 563, Issue:1

    Topics: Animals; Biomarkers; Cell Survival; Cells, Cultured; Chromatography, High Pressure Liquid; DNA Adduc

2004
Biologically motivated computational modeling: contribution to risk assessment.
    Toxicological sciences : an official journal of the Society of Toxicology, 2004, Volume: 82, Issue:1

    Topics: Administration, Inhalation; Animals; Carcinogens; Computational Biology; Formaldehyde; Humans; Model

2004
Uncertainties in the CIIT model for formaldehyde-induced carcinogenicity in the rat: a limited sensitivity analysis-I.
    Risk analysis : an official publication of the Society for Risk Analysis, 2007, Volume: 27, Issue:5

    Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Cocarcinogenesis; Cross-Linking Reage

2007
Cancer risk from formaldehyde.
    Lancet (London, England), 1980, Aug-30, Volume: 2, Issue:8192

    Topics: Aged; Animals; Formaldehyde; Humans; Middle Aged; Neoplasms; Nose Neoplasms; Rats; Risk

1980
Formaldehyde in the British chemical industry. An occupational cohort study.
    Lancet (London, England), 1984, Mar-17, Volume: 1, Issue:8377

    Topics: Chemical Industry; England; Environmental Exposure; Formaldehyde; Humans; Lung Neoplasms; Male; Nose

1984
Cohort study of formaldehyde process workers.
    Lancet (London, England), 1984, Aug-18, Volume: 2, Issue:8399

    Topics: Animals; Formaldehyde; Humans; Lung Neoplasms; Male; Nose Neoplasms; Occupational Diseases; Rats

1984
Differentiation between metabolic incorporation and covalent binding in the labeling of macromolecules in the rat nasal mucosa and bone marrow by inhaled [14C]- and [3H]formaldehyde.
    Toxicology and applied pharmacology, 1984, Volume: 76, Issue:1

    Topics: Animals; Bone Marrow; DNA; Formaldehyde; Male; Nose Neoplasms; Proteins; Rats; Rats, Inbred F344; RN

1984
Some effects of formaldehyde on the upper respiratory tract.
    The Laryngoscope, 1984, Volume: 94, Issue:11 Pt 1

    Topics: Air Pollutants; Animals; Formaldehyde; Haplorhini; Housing; Humans; Male; Mice; Middle Aged; Nasal M

1984
Occupational formaldehyde exposure and increased nasal cancer risk in man.
    International journal of cancer, 1984, Nov-15, Volume: 34, Issue:5

    Topics: Air Pollutants, Occupational; Denmark; Dust; Formaldehyde; Humans; Male; Nose Neoplasms; Occupationa

1984
Uses of computer-generated maps in occupational hazard and mortality surveillance.
    Scandinavian journal of work, environment & health, 1983, Volume: 9, Issue:2 Spec No

    Topics: Aged; Computers; Environmental Exposure; Formaldehyde; Humans; Male; Maps as Topic; Mortality; Natio

1983
Formaldehyde and nasal cancer mortality.
    Canadian Medical Association journal, 1983, Feb-01, Volume: 128, Issue:3

    Topics: Animals; Formaldehyde; Humans; Nose Neoplasms; Occupational Diseases; Rats; Rats, Inbred Strains

1983
Nasal cancer in a worker exposed to formaldehyde.
    JAMA, 1983, Jan-28, Volume: 249, Issue:4

    Topics: Carcinoma, Squamous Cell; Formaldehyde; Humans; Male; Middle Aged; Nasal Cavity; Nose Neoplasms; Occ

1983
Carcinogenicity of formaldehyde in rats and mice after long-term inhalation exposure.
    Cancer research, 1983, Volume: 43, Issue:9

    Topics: Animals; Body Weight; Carcinogens; Dose-Response Relationship, Drug; Female; Formaldehyde; Male; Mic

1983
Gaseous formaldehyde and hydrogen chloride induction of nasal cancer in the rat.
    Journal of the National Cancer Institute, 1982, Volume: 68, Issue:4

    Topics: Animals; Bis(Chloromethyl) Ether; Body Weight; Drug Interactions; Formaldehyde; Gases; Humans; Hydro

1982
Report of the Federal Panel on Formaldehyde.
    Environmental health perspectives, 1982, Volume: 43

    Topics: Abnormalities, Drug-Induced; Adult; Animals; Chemical Phenomena; Chemistry; Cross-Sectional Studies;

1982
Carcinogenicity of formaldehyde vapor: interim findings in a long-term bioassay of rats and mice.
    Developments in toxicology and environmental science, 1980, Volume: 8

    Topics: Animals; Carcinogens, Environmental; Carcinoma, Squamous Cell; Female; Formaldehyde; Male; Mice; Neo

1980
Induction of squamous cell carcinomas of the rat nasal cavity by inhalation exposure to formaldehyde vapor.
    Cancer research, 1980, Volume: 40, Issue:9

    Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Environmental Expo

1980
IARC evaluates wood dust and formaldehyde. International Agency for Research on Cancer.
    Scandinavian journal of work, environment & health, 1995, Volume: 21, Issue:3

    Topics: Animals; Case-Control Studies; Dust; Formaldehyde; Humans; Nose Neoplasms; Occupational Diseases; Ri

1995
Formaldehyde and cancer morbidity among male employees in Denmark.
    Cancer causes & control : CCC, 1995, Volume: 6, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Denmark; Formaldehyde; Humans; Male; Middle Aged; Neoplasms; Nose Ne

1995
Immunohistochemical localization of p53, PCNA, and TGF-alpha proteins in formaldehyde-induced rat nasal squamous cell carcinomas.
    Toxicology and applied pharmacology, 1995, Volume: 132, Issue:1

    Topics: Animals; Carcinoma, Squamous Cell; Formaldehyde; Immunoenzyme Techniques; Male; Nose Neoplasms; Prol

1995
Use of biological markers in risk assessment.
    Risk analysis : an official publication of the Society for Risk Analysis, 1994, Volume: 14, Issue:5

    Topics: Animals; Biological Assay; Biomarkers; Biomarkers, Tumor; Carcinoma, Squamous Cell; Formaldehyde; Hu

1994
Sources of discrepancies between a job exposure matrix and a case by case expert assessment for occupational exposure to formaldehyde and wood-dust.
    International journal of epidemiology, 1993, Volume: 22 Suppl 2

    Topics: Case-Control Studies; Dust; Formaldehyde; Humans; Laryngeal Neoplasms; Methods; Nose Neoplasms; Occu

1993
Characterization of cell lines derived from formaldehyde-induced nasal tumors in rats.
    Molecular carcinogenesis, 1994, Volume: 9, Issue:4

    Topics: Animals; Carcinoma; Cell Line; Female; Formaldehyde; Gene Expression Regulation, Neoplastic; Genes,

1994
Nasal melanoma.
    British journal of industrial medicine, 1993, Volume: 50, Issue:8

    Topics: Formaldehyde; Humans; Melanoma; Nose Neoplasms; Occupational Diseases; Occupational Exposure

1993
A cohort study of workers exposed to formaldehyde in the British chemical industry: an update.
    British journal of industrial medicine, 1993, Volume: 50, Issue:9

    Topics: Chemical Industry; Cohort Studies; Follow-Up Studies; Formaldehyde; Humans; Lung Neoplasms; Male; Ne

1993
Sinonasal cancer and occupational exposure to formaldehyde and other substances.
    International journal of cancer, 1993, Jan-21, Volume: 53, Issue:2

    Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Dust; Female; Formaldehyde; France; Humans; Male; Nose Neo

1993
DNA--protein crosslinks, a biomarker of exposure to formaldehyde--in vitro and in vivo studies.
    Carcinogenesis, 1996, Volume: 17, Issue:1

    Topics: Biomarkers; Carcinogens; Carcinoma, Squamous Cell; DNA; Formaldehyde; Humans; Leukocytes; Nose Neopl

1996
Correlation of regional and nonlinear formaldehyde-induced nasal cancer with proliferating populations of cells.
    Cancer research, 1996, Mar-01, Volume: 56, Issue:5

    Topics: Animals; Carcinoma, Squamous Cell; Cell Division; Dose-Response Relationship, Drug; Formaldehyde; Ma

1996
Follow your nose.
    Human & experimental toxicology, 1996, Volume: 15, Issue:11

    Topics: Animals; Carcinoma, Squamous Cell; Formaldehyde; Nose Neoplasms; Rats

1996
Results of a 28-month chronic inhalation toxicity study of formaldehyde in male Fisher-344 rats.
    The Journal of toxicological sciences, 1997, Volume: 22, Issue:3

    Topics: Administration, Inhalation; Animals; Body Weight; Dose-Response Relationship, Drug; Eating; Formalde

1997
Occupational exposure to chlorophenol and the risk of nasal and nasopharyngeal cancers among U.S. men aged 30 to 60.
    American journal of industrial medicine, 2000, Volume: 37, Issue:5

    Topics: Adult; Case-Control Studies; Chlorophenols; Confidence Intervals; Confounding Factors, Epidemiologic

2000
Fume-induced fluorescence in diagnosis of nasal neuroblastoma.
    Archives of otolaryngology (Chicago, Ill. : 1960), 1976, Volume: 102, Issue:2

    Topics: Formaldehyde; Humans; Microscopy, Electron; Microscopy, Fluorescence; Neuroectodermal Tumors, Primit

1976
p53 mutations in formaldehyde-induced nasal squamous cell carcinomas in rats.
    Cancer research, 1992, Nov-01, Volume: 52, Issue:21

    Topics: Animals; Base Sequence; Carcinoma, Squamous Cell; DNA, Neoplasm; Formaldehyde; Genes, p53; Molecular

1992
Malignant melanomas of the nasal cavity after occupational exposure to formaldehyde.
    British journal of industrial medicine, 1991, Volume: 48, Issue:1

    Topics: Aged; Female; Formaldehyde; Humans; Melanoma; Middle Aged; Nasal Mucosa; Nose Neoplasms; Occupationa

1991
Immunohistochemical differential diagnosis of granulocytic sarcomas and malignant lymphomas on formalin-fixed material.
    Virchows Archiv. A, Pathological anatomy and histopathology, 1990, Volume: 416, Issue:4

    Topics: Child; Diagnosis, Differential; Female; Fixatives; Formaldehyde; Humans; Immunohistochemistry; Leuke

1990
Nasal mucosa in workers exposed to formaldehyde: a pilot study.
    British journal of industrial medicine, 1990, Volume: 47, Issue:2

    Topics: Adult; Aged; Chemical Industry; Formaldehyde; Humans; Middle Aged; Nasal Mucosa; Nose Neoplasms; Occ

1990
Nasal tumours in rats after severe injury to the nasal mucosa and prolonged exposure to 10 ppm formaldehyde.
    Journal of applied toxicology : JAT, 1989, Volume: 9, Issue:1

    Topics: Animals; Body Weight; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Electrocoagulation

1989
Mortality among industrial workers exposed to formaldehyde.
    Journal of the National Cancer Institute, 1986, Volume: 76, Issue:6

    Topics: Adult; Environmental Exposure; Female; Formaldehyde; Hodgkin Disease; Humans; Industry; Leukemia; Lu

1986
Nasopharyngeal cancer, sinonasal cancer, and occupations related to formaldehyde: a case-control study.
    Journal of the National Cancer Institute, 1987, Volume: 79, Issue:6

    Topics: Formaldehyde; Humans; Male; Nasopharyngeal Neoplasms; Nose Neoplasms; Occupational Diseases; Paranas

1987
Time and age trends for sinonasal cancer in Connecticut incidence and US mortality rates.
    Cancer, 1987, Aug-01, Volume: 60, Issue:3

    Topics: Age Factors; Connecticut; Female; Formaldehyde; Humans; Male; Nose Neoplasms; Paranasal Sinus Neopla

1987
Occupational formaldehyde exposure and the nasal mucosa.
    Rhinology, 1987, Volume: 25, Issue:3

    Topics: Adult; Aged; Formaldehyde; Humans; Metaplasia; Middle Aged; Nasal Mucosa; Nose Diseases; Nose Neopla

1987
Decreased extractability of DNA from proteins in the rat nasal mucosa after acetaldehyde exposure.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1986, Volume: 6, Issue:3

    Topics: Acetaldehyde; Animals; Cross-Linking Reagents; DNA; Dose-Response Relationship, Drug; Formaldehyde;

1986
[Hobby and occupation as causes of cancer].
    Nederlands tijdschrift voor geneeskunde, 1986, May-31, Volume: 130, Issue:22

    Topics: Adult; Azo Compounds; Coloring Agents; Female; Formaldehyde; Hobbies; Humans; Male; Neoplasms; Nose

1986
Induction of nasal tumors in rats exposed to mixtures of hydrochloric acid (HCl) and formaldehyde (HCHO) by inhalation.
    Toxicology and applied pharmacology, 1986, Sep-15, Volume: 85, Issue:2

    Topics: Administration, Inhalation; Animals; Bis(Chloromethyl) Ether; Formaldehyde; Hydrochloric Acid; Methy

1986
Inhalation toxicity of acetaldehyde in rats. III. Carcinogenicity study.
    Toxicology, 1986, Volume: 41, Issue:2

    Topics: Acetaldehyde; Adenocarcinoma; Administration, Inhalation; Animals; Body Weight; Carcinoma, Squamous

1986
Formaldehyde and the risk of squamous cell carcinoma of the sinonasal cavities.
    British journal of industrial medicine, 1986, Volume: 43, Issue:11

    Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Denmark; Female; Formaldehyde; Humans; Male; Nasopharyngea

1986
Formaldehyde: toxicology and hazards.
    Veterinary and human toxicology, 1987, Volume: 29, Issue:1

    Topics: Air Pollutants; Animals; Formaldehyde; Humans; Nose Neoplasms; Respiratory Tract Diseases; Skin Dise

1987
[The environment and cancer].
    Schriftenreihe des Vereins fur Wasser-, Boden- und Lufthygiene, 1985, Volume: 65

    Topics: Animals; Asbestos; Carcinogens, Environmental; Carcinoma, Squamous Cell; Formaldehyde; Humans; Lung

1985
More precise localization of nasal tumors associated with chronic exposure of F-344 rats to formaldehyde gas.
    Toxicology and applied pharmacology, 1986, Volume: 82, Issue:2

    Topics: Animals; Carcinoma, Squamous Cell; Female; Formaldehyde; Gases; Male; Nasal Polyps; Nose; Nose Neopl

1986
Cancer of the nasal cavity and paranasal sinuses, and formaldehyde exposure.
    International journal of cancer, 1986, Apr-15, Volume: 37, Issue:4

    Topics: Adenocarcinoma; Adult; Aged; Carcinoma, Squamous Cell; Dust; Formaldehyde; Humans; Male; Middle Aged

1986
Formaldehyde and the nasal mucosa.
    British journal of industrial medicine, 1985, Volume: 42, Issue:8

    Topics: Adult; Formaldehyde; Humans; Male; Middle Aged; Nasal Mucosa; Nose Neoplasms; Occupational Diseases;

1985
Sensory irritation potential of selected nasal tumorigens in the rat.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 1985, Volume: 23, Issue:1

    Topics: Animals; Carcinogens; Epichlorohydrin; Formaldehyde; Gases; Hempa; Hydrocarbons, Chlorinated; Irrita

1985
The role of mechanistic data in dose-response modeling.
    Basic life sciences, 1985, Volume: 33

    Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cell Division; Dose-Response Relationship, Drug; For

1985
Formaldehyde: laboratory evidence.
    IARC scientific publications, 1985, Issue:65

    Topics: Animals; Carcinoma, Squamous Cell; Cricetinae; Female; Formaldehyde; Male; Mice; Nose Neoplasms; Rab

1985
Formaldehyde: epidemiological evidence.
    IARC scientific publications, 1985, Issue:65

    Topics: Formaldehyde; Humans; Male; Neoplasms; Nose Neoplasms; Occupational Diseases

1985