formaldehyde has been researched along with Breast Neoplasms in 341 studies
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy
Breast Neoplasms: Tumors or cancer of the human BREAST.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study aimed to investigate whether LSD1 in metastasized MRMT-1 breast cancer cells in bone marrows participated in the production of endogenous formaldehyde in bone cancer pain rats." | 7.79 | Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats. ( Cai, J; Chen, W; Li, H; Li, ZH; Liao, FF; Liu, FY; Liu, J; Luo, HJ; Luo, WH; Tang, JM; Tang, Y; Tong, ZQ; Wan, Y, 2013) |
| " Accumulated evidence shows that endogenous formaldehyde concentrations are elevated in the blood or urine of patients with breast, prostate or bladder cancer." | 7.76 | Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. ( Duan, B; Han, Y; Li, H; Liu, F; Luo, H; Luo, W; Maoying, Q; Tan, H; Tong, Z; Wan, Y; Wang, J; Wang, Y; Xu, T; Yang, F; Zhao, H, 2010) |
| "The combination of doxorubicin and mitomycin C has been shown previously to result in supra-additive tumor cell killing in vitro in both murine and human breast cancer cells and in vivo against murine breast cancer cells." | 7.74 | On the synergistic effect of doxorubicin and mitomycin C against breast cancer cells. ( O'Brien, PJ; Rauth, AM; Shuhendler, AJ; Wu, XY, 2007) |
| " We have recently reported the design, synthesis, and preliminary evaluation of a doxorubicin-formaldehyde conjugate targeted, via 4-hydroxytamoxifen, to the estrogen receptor (ER) and antiestrogen binding site (AEBS), which are commonly present in breast cancer cells." | 7.72 | Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells. ( Burke, PJ; Kalet, BT; Koch, TH, 2004) |
| "Selected ion flow tube-chemical ionization mass spectrometry was used to measure formaldehyde levels in human breast cancer cells in comparison with levels in cells treated with the antitumor drugs doxorubicin (DOX) and daunorubicin (DAU) and the daunorubicin-formaldehyde conjugate Daunoform (DAUF)." | 7.70 | Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs. ( Bierbaum, VM; Burke, PJ; Fenick, DJ; Kato, S; Koch, TH; Taatjes, DJ, 2000) |
| "If a breast cancer patient expresses ER or PR, a chemotherapy with estrogen inhibitors such as tamoxifen is supposed to be effective." | 5.40 | Evaluation of BrightGen HR RT-qDx assay to detect nuclear receptors mRNA overexpression in FFPE breast cancer tissue samples for selection of tamoxifen therapy. ( Ahn, S; Jung, D; Kim, S; Lee, D; Lee, H; Park, KH; Park, S; Wang, HY, 2014) |
| "One hundred thirty-two breast carcinomas were studied retrospectively using formalin fixed, paraffin embedded archival tissues on which S-LI and S-flow had been obtained originally." | 5.29 | Assessment of proliferating cell nuclear antigen (PCNA) in breast cancer using anti-PCNA PC10 and 19A2: correlation with 5-bromo-2'-deoxyuridine or tritiated thymidine labeling and flow cytometric analysis. ( He, W; Hughes, J; Koehm, S; Meyer, JS; Scrivner, DL, 1994) |
| "Experimental therapeutic regimens for breast cancer include strategies to block the activity of specific oncogenes." | 5.29 | Plasma membrane phosphotyrosine, Her2-NEU, and epidermal growth factor receptor in human breast cancer. A comparative study. ( Fenoglio-Preiser, CM; Heffelfinger, SC; Lower, EE; Miller, MA, 1996) |
| "Tamoxifen is a key therapeutic option for breast cancer treatment." | 3.80 | Extraction of tamoxifen and its metabolites from formalin-fixed, paraffin-embedded tissues: an innovative quantitation method using liquid chromatography and tandem mass spectrometry. ( Kangarloo, SB; Konno, M; Magliocco, AM; Ng, ES; Paterson, A, 2014) |
| "Development of peripheral neuropathy, which can present as painful neuropathy or loss of sensation, sometimes limit the use of paclitaxel in the treatment of solid tumors such as breast cancer." | 3.80 | Paclitaxel-induced hyposensitivity to nociceptive chemical stimulation in mice can be prevented by treatment with minocycline. ( Masocha, W, 2014) |
| "This study aimed to investigate whether LSD1 in metastasized MRMT-1 breast cancer cells in bone marrows participated in the production of endogenous formaldehyde in bone cancer pain rats." | 3.79 | Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats. ( Cai, J; Chen, W; Li, H; Li, ZH; Liao, FF; Liu, FY; Liu, J; Luo, HJ; Luo, WH; Tang, JM; Tang, Y; Tong, ZQ; Wan, Y, 2013) |
| " Here, we report an advanced case of breast cancer with vertebra-Th7 metastasis that showed complete response to combined treatments with formalin-fixed autologous tumor vaccine (AFTV), palliative radiation therapy with 36 Gy, and adjuvant chemotherapy with standardized CEF (cyclophosphamide, epirubicin, and 5FU), zoledronic acid, and aromatase inhibitors following mastectomy for the breast tumor." | 3.79 | Eradication of breast cancer with bone metastasis by autologous formalin-fixed tumor vaccine (AFTV) combined with palliative radiation therapy and adjuvant chemotherapy: a case report. ( Kuranishi, F; Ohno, T, 2013) |
| "We assessed morphology and ERalpha protein and gene expression of two breast cancer cell lines after three different fixatives: neutral-buffered 10% formaldehyde, LN-FIX and FineFIX and varying fixation times." | 3.76 | Protein and gene expression of estrogen receptor alpha and nuclear morphology of two breast cancer cell lines after different fixation methods. ( Kuopio, T; Nykänen, M, 2010) |
| " Accumulated evidence shows that endogenous formaldehyde concentrations are elevated in the blood or urine of patients with breast, prostate or bladder cancer." | 3.76 | Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. ( Duan, B; Han, Y; Li, H; Liu, F; Luo, H; Luo, W; Maoying, Q; Tan, H; Tong, Z; Wan, Y; Wang, J; Wang, Y; Xu, T; Yang, F; Zhao, H, 2010) |
| "The combination of doxorubicin and mitomycin C has been shown previously to result in supra-additive tumor cell killing in vitro in both murine and human breast cancer cells and in vivo against murine breast cancer cells." | 3.74 | On the synergistic effect of doxorubicin and mitomycin C against breast cancer cells. ( O'Brien, PJ; Rauth, AM; Shuhendler, AJ; Wu, XY, 2007) |
| " We have recently reported the design, synthesis, and preliminary evaluation of a doxorubicin-formaldehyde conjugate targeted, via 4-hydroxytamoxifen, to the estrogen receptor (ER) and antiestrogen binding site (AEBS), which are commonly present in breast cancer cells." | 3.72 | Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells. ( Burke, PJ; Kalet, BT; Koch, TH, 2004) |
| "Selected ion flow tube-chemical ionization mass spectrometry was used to measure formaldehyde levels in human breast cancer cells in comparison with levels in cells treated with the antitumor drugs doxorubicin (DOX) and daunorubicin (DAU) and the daunorubicin-formaldehyde conjugate Daunoform (DAUF)." | 3.70 | Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs. ( Bierbaum, VM; Burke, PJ; Fenick, DJ; Kato, S; Koch, TH; Taatjes, DJ, 2000) |
| "Formaldehyde, acetaldehyde and acetone expired from tumor-bearing transgenic mice and formaldehyde exhaled from breast cancer patients were analyzed using gas chromatography." | 3.69 | Quantitative analysis by gas chromatography of volatile carbonyl compounds in expired air from mice and human. ( Clifford, AJ; Ebeler, SE; Shibamoto, T, 1997) |
| "Sixty-seven cases of breast cancer were studied by ICA for ER using monoclonal antibody D75 in routinely processed formaldehyde-fixed paraffin-embedded tissue, employing ficin predigestion of sections before application of D75." | 3.68 | Immunocytochemical assay for estrogen receptor with monoclonal antibody D753P gamma in routinely processed formaldehyde-fixed breast tissue. Comparison with frozen section assay and with monoclonal antibody H222. ( Greene, GL; Hapke, MR; Miller, RT, 1993) |
| "To investigate the effect of ligand (be it hormone, antihormone, or no hormone) on the interaction between estrogen receptor (ER) and chromatin, we have used formaldehyde as a cross-linking agent in intact MCF-7 human breast cancer cells." | 3.68 | Cross-linking of estrogen receptor to chromatin in intact MCF-7 human breast cancer cells: optimization and effect of ligand. ( Katzenellenbogen, BS; Wrenn, CK, 1990) |
| "In patients with early node-negative breast cancer who were endocrine-only treated, 38% were GG1 with a 10-year DRFI of 99% (95% CI, 97%-100%), and 18% were histological grade 1 with a 10-year DRFI of 100% (95% CI, 100%-100%)." | 2.82 | The Genomic Grade Assay Compared With Ki67 to Determine Risk of Distant Breast Cancer Recurrence. ( Azim, HA; Dell'Orto, P; Desmedt, C; Ditzel, HJ; Giobbie-Hurder, A; Ignatiadis, M; Kammler, R; Laïos, I; Larsimont, D; Leyland-Jones, B; Lyng, MB; Michiels, S; Piccart, M; Regan, MM; Rothé, F; Salgado, R; Sotiriou, C; Veys, I; Viale, G, 2016) |
| "Evidence is accumulating that breast cancer is not one disease but many separate diseases." | 2.44 | Molecular subtyping of breast cancer: opportunities for new therapeutic approaches. ( Millikan, RC; Mullan, PB, 2007) |
| "Breast cancer is a heterogenous disease in terms of both clinical behavior and molecular characteristics." | 2.43 | Technology insight: Application of molecular techniques to formalin-fixed paraffin-embedded tissues from breast cancer. ( Kim, CY; Kim, WS; Paik, S; Song, YK, 2005) |
| "Cellular cytology scrapes from all 11 breast cancers were fixed and stained using three common protocols: Carnoy's (CS_C) or 95% ethanol (CS_E) fixation and then Papanicolaou stain or air-dried then methanol fixation and DiffQuik stain (CS_DQ)." | 1.91 | Assessment of stained direct cytology smears of breast cancer for whole transcriptome and targeted messenger RNA sequencing. ( Du, L; Fu, C; Gould, RE; Hatzis, C; Lau, R; Marczyk, M; Pusztai, L; Sinn, BV; Symmans, WF; Trevarton, AJ, 2023) |
| "Breast cancer is a type of cancer with the highest incidence worldwide in 2021, with early diagnosis and rapid treatment intervention being the reasons for the decreasing mortality rate associated with the disease." | 1.72 | Breast cancer or surrounding normal tissue? A successful discrimination by FTIR or Raman microspectroscopy. ( Batista de Carvalho, ALM; Batista de Carvalho, LAE; Figueiredo, P; Mamede, AP; Marques, MPM; Santos, IP; Silva, MC, 2022) |
| "Matched tissue samples from 12 breast cancers were fresh frozen (FF) and preserved in RNAlater or fixed in formalin and processed as FFPE tissue." | 1.51 | The impact of RNA extraction method on accurate RNA sequencing from formalin-fixed paraffin-embedded tissues. ( Du, L; Fu, C; Gould, RE; Hatzis, C; Lau, R; Marczyk, M; Pusztai, L; Sinn, BV; Symmans, WF; Trevarton, AJ, 2019) |
| "True archival FFPE breast cancer cases (n = 58), stored at room temperature for 2-23 years, were utilized to identify key steps in tissue selection, RNA isolation, and library choice." | 1.51 | RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery. ( Burchard, J; Carbone, L; Fei, SS; Harrington, CA; Horton, W; Jindal, S; Narasimhan, J; Pennock, ND; Schedin, P; Searles, R; Sun, D; Weinmann, S; Xia, Z, 2019) |
| "Biomarker analysis of metastatic breast carcinoma (MBC) is routinely recommended by ASCO/CAP guidelines, and establishing a diagnosis of MBC often requires immunohistochemistry (IHC)." | 1.51 | Effects of Hydrochloric Acid and Formic Acid Decalcification on Breast Tumor Biomarkers and HER2 Fluorescence In Situ Hybridization. ( Clark, BZ; Dabbs, DJ; Onisko, A; Yoest, JM, 2019) |
| "Last, in the 4T1 model of breast cancer, we demonstrate the utility of our protocol and Ab panels in the quantitation and spatial distribution of immune cells." | 1.51 | Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues. ( Brekken, RA; Burton, N; Dahal, LN; Dominguez, ATA; Ganguly, D; Huang, H; Sorrelle, N; Zhang, Y; Ziemys, A, 2019) |
| "Formalin-fixed human breast cancer core-needle biopsy specimens, were embedded, lipid-cleared, and multiplexed immunostained to identify key biomarkers (pan-cytokeratin, Ki67, CD3)." | 1.51 | Three-dimensional imaging and quantitative analysis in CLARITY processed breast cancer tissues. ( Badve, S; Chen, Y; Gokmen-Polar, Y; Goodman, LJ; Shen, Q; White, SL, 2019) |
| "Invasive ductal breast cancer FFPE tissue sections from five patients are analyzed by MALDI imaging and the dataset is processed by segmentation." | 1.48 | MALDI Imaging-Guided Microproteomic Analyses of Heterogeneous Breast Tumors-A Pilot Study. ( Alberts, D; Baiwir, D; De Pauw, E; Delvenne, P; Kazdal, D; Kriegsmann, M; Longuespée, R; Mazzucchelli, G; Pottier, C; Smargiasso, N; Warth, A, 2018) |
| "The transition from ductal carcinoma in situ (DCIS) to invasive breast carcinoma (IBC) is an important step during breast carcinogenesis." | 1.48 | Progression-specific genes identified in microdissected formalin-fixed and paraffin-embedded tissue containing matched ductal carcinoma in situ and invasive ductal breast cancers. ( Bartsch, H; Bonin, M; Fehm, T; Harbeck, N; Kahlert, S; Neubauer, HJ; Petat-Dutter, K; Schultz, S; Seeger, H; Sotlar, K; Vogel, U, 2018) |
| "Afterward, another 51 equivocal IHC 2+ gastric cancer samples were further determined by FISH and ddPCR, respectively, and the concordance between ddPCR and FISH was calculated." | 1.46 | Human epidermal growth factor receptor 2 amplification detection by droplet digital polymerase chain reaction in formalin-fixed paraffin-embedded breast and gastric cancer samples. ( Feng, H; Song, X; Sun, C; Wang, X; Wu, C; Wu, Y, 2017) |
| "Metastases from primary breast cancers can involve single or multiple organs at metastatic disease diagnosis." | 1.46 | Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study. ( Buus, R; Dowsett, M; Gillett, CE; Grigoriadis, A; Hedenfalk, I; Holmberg, L; Kimbung, S; Lawler, K; Mera, A; Naceur-Lombardelli, C; Ng, T; Ougham, K; Papouli, E; Parker, P; Pinder, SE; Purushotham, A; Tutt, A; Zhan, J; Zhang, H, 2017) |
| "DNA extracted from gastric cancer FFPE samples prepared within the last 7 years is suitable for NGS analysis, whereas those older than 7 years may not be suitable." | 1.46 | Formalin-fixed paraffin-embedded sample conditions for deep next generation sequencing. ( Homma, K; Ichikawa, H; Kaneko, K; Kawasaki, T; Kodama, K; Lyle, S; Nagahashi, M; Nakagawa, S; Sato, N; Shimada, Y; Takabe, K; Wakai, T, 2017) |
| "This study confirms mRNA analysis in breast carcinoma formalin-fixed, paraffin-embedded samples is feasible and suggests gene expression profiling, using a small set of five proliferation genes, has potential in aiding histological grading or assessment of proliferative activity of breast cancers." | 1.46 | Expression of proliferation genes in formalin-fixed paraffin-embedded (FFPE) tissue from breast carcinomas. Feasibility and relevance for a routine histopathology laboratory. ( Amanuel, B; Dessauvagie, B; Harvey, J; Robinson, C; Sterrett, G; Thomas, C; Wood, B, 2017) |
| "As a case study, we will describe a breast cancer-focused super-SILAC approach, which we used in a recent publication to profile hPTMs in frozen and formalin-fixed paraffin-embedded human samples, revealing previously unknown marks that differentiate breast cancer subtypes." | 1.46 | A Super-SILAC Strategy for the Accurate and Multiplexed Profiling of Histone Posttranslational Modifications. ( Bonaldi, T; Noberini, R, 2017) |
| "The early stage of breast cancer identification is the key challenge in cancer control and prevention procedures." | 1.43 | Proteomic Analysis of Stage-II Breast Cancer from Formalin-Fixed Paraffin-Embedded Tissues. ( Abdullah Al-Dhabi, N; Agastian, P; Baaru, R; Balamurugan, K; Choi, KC; Ilavenil, S; Kim, YO; Srigopalram, S; Valan Arasu, M, 2016) |
| "Taken together with somatic breast cancer genome data, these results point to a breakdown in a BRCA/FA-mSWI/SNF-ΔNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells that may contribute to sporadic breast cancer development." | 1.43 | BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells. ( Bierie, B; Dimitrov, SD; Feunteun, J; Gelman, R; Giobbie-Hurder, A; Li, AG; Liu, B; Livingston, DM; Pathania, S; Polyak, K; Toomire, K; Wang, H, 2016) |
| "The development of breast and ovarian cancer is strongly connected to the inactivation of the BRCA1 and BRCA2 genes by different germline and somatic alterations, and their diagnosis has great significance in targeted tumor therapy, since recently approved PARP inhibitors show high efficiency in the treatment of BRCA-deficient tumors." | 1.43 | Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples. ( Gyuris, Z; Hajdu, A; Haracska, L; Határvölgyi, E; Jaksa, G; Pintér, L; Priskin, K; Sükösd, F, 2016) |
| "Samples utilized were obtained from the breast cancer tumour bank held at the Cambridge University Hospitals NHS Foundation Trust." | 1.43 | Reliable gene expression profiling of formalin-fixed paraffin-embedded breast cancer tissue (FFPE) using cDNA-mediated annealing, extension, selection, and ligation whole-genome (DASL WG) assay. ( Caldas, C; Earl, HM; Graf, S; Iddawela, M; Klarqvist, M; Rueda, OM, 2016) |
| "Chemoresistance mediated by miRNAs in breast cancer have been already validated by previous studies in vitro, while little is known concerning the expression of them in vivo." | 1.43 | The role of miRNAs in drug resistance and prognosis of breast cancer formalin-fixed paraffin-embedded tissues. ( Chen, X; Lu, P; Shen, HY; Tang, JH; Wang, DD; Wu, Y; Yang, SJ; Zhao, JH; Zhong, SL, 2016) |
| "Screening for germline mutations in breast cancer-associated genes BRCA1 and BRCA2 is indicated for patients with breast cancer from high-risk breast cancer families and influences both treatment options and clinical management." | 1.42 | MicroRNA expression signatures for the prediction of BRCA1/2 mutation-associated hereditary breast cancer in paraffin-embedded formalin-fixed breast tumors. ( Benítez, J; Gómez-López, G; Marquez-Rodas, I; Martinez-Delgado, B; Osorio, A; Pisano, DG; Rodriguez-Pinilla, MS; Tanic, M; Yanowski, K, 2015) |
| "A tissue microarray consisting of 93 breast cancer specimens with documented time-to-fixation was used to evaluate changes in antigenicity of 12 phosphoepitopes frequently used in research settings as a function of cold ischemic time." | 1.42 | Preanalytical variables and phosphoepitope expression in FFPE tissue: quantitative epitope assessment after variable cold ischemic time. ( Anagnostou, V; England, AM; Hicks, DG; Kluger, Y; Neumeister, VM; Parisi, F; Rimm, DL; Siddiqui, S; Vassilakopoulou, M; Zarella, ER, 2015) |
| "In approximately 5% of breast cancers, ISH assays fail." | 1.42 | Evaluation of HER2 Gene Status in Breast Cancer Samples with Indeterminate Fluorescence in Situ Hybridization by Quantitative Real-Time PCR. ( Berkovcova, J; Ehrmann, J; Hajduch, M; Kolar, Z; Koudelakova, V; Melichar, B; Radova, L; Trojanec, R; Vrbkova, J, 2015) |
| "Diagnosis of basal-like breast cancer (BLBC) remains a bottleneck to conducting effective clinical trials for this aggressive subtype." | 1.42 | Diagnosis of Basal-Like Breast Cancer Using a FOXC1-Based Assay. ( Bagaria, SP; Bellafiore, F; Cui, X; Han, B; Jensen, TW; Li, X; Naritoku, WY; Qu, A; Ray, PS; Ray, T; Taylor, CR; Wang, J, 2015) |
| "Xenografted tumor tissues of the human gastric cancer cell lines NCI-N87, SCH, and SNU-16 were collected and kept at room temperature for 0, 6, or 24 h before being fixed with 10 % neutral buffered formalin (NBF) for 24 h or 5, 7, or 10 days and embedded in paraffin." | 1.40 | Importance of formalin fixing conditions for HER2 testing in gastric cancer: immunohistochemical staining and fluorescence in situ hybridization. ( Fujimoto-Ouchi, K; Harada, N; Hashizume, K; Moriya, Y; Shu, S; Yamashita-Kashima, Y; Yorozu, K, 2014) |
| "NanoString's Prosigna™ Breast Cancer Prognostic Gene Signature Assay is based on the PAM50 gene expression signature." | 1.40 | Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens. ( Barry, G; Dowidar, N; Ferree, S; Gao, D; Liu, S; Maysuria, M; Nielsen, T; Schaper, C; Storhoff, J; Wallden, B, 2014) |
| "In patients with invasive breast carcinoma, estrogen receptor α (ERα) and progesterone receptor (PR) expressions need to be assessed in core-needle biopsies (CNBs) before the start of neoadjuvant systemic treatment." | 1.40 | Brief fixation does not affect assessment of hormone receptor expression in invasive breast carcinoma biopsies: paving the road for same-day tissue diagnostics. ( Barentsz, MW; Kalkman, S; van der Wall, E; van Diest, PJ; Verkooijen, HM; Witkamp, AJ, 2014) |
| "The level of brachyury expression in breast cancer cells was positively associated with their ability to invade the extracellular matrix, efficiently form mammospheres in vitro, and resist the cytotoxic effect of docetaxel." | 1.40 | Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis. ( Cavaliere, F; Cheng, Q; Costarelli, L; Fernando, RI; Ferroni, P; Guadagni, F; Hamilton, DH; Huang, B; Jochems, C; Litzinger, MT; Lyerly, HK; Palena, C; Roselli, M; Schlom, J; Spila, A; Tsang, KY, 2014) |
| "Formalin-fixed, paraffin-embedded breast carcinoma specimens were core-punched using 1." | 1.40 | Intratumoral DNA content heterogeneity in breast carcinomas demonstrated by core punch tissue sampling and flow cytometry. ( Evans, MF; Munjal, K; Weaver, DL; Zhang, Z, 2014) |
| "The heterogeneity among multiple ductal carcinoma in situ (DCIS) lesions within the same patient also diagnosed with invasive ductal carcinoma (IDC) has not been well evaluated, leaving research implications of intra-individual DCIS heterogeneity yet to be explored." | 1.40 | Identifying a highly-aggressive DCIS subgroup by studying intra-individual DCIS heterogeneity among invasive breast cancer patients. ( Cai, KQ; Chen, X; Daly, MB; Devarajan, K; Jiang, Z; Pape-Zambito, D; Patchefsky, A; Slater, CM; Wu, H, 2014) |
| "HER2 status is an integral part of breast cancer management." | 1.40 | Delay to formalin fixation effect on HER2 test in breast cancer by dual-color silver-enhanced in situ hybridization (Dual-ISH). ( Khoury, T; Liu, Q; Liu, S, 2014) |
| "If a breast cancer patient expresses ER or PR, a chemotherapy with estrogen inhibitors such as tamoxifen is supposed to be effective." | 1.40 | Evaluation of BrightGen HR RT-qDx assay to detect nuclear receptors mRNA overexpression in FFPE breast cancer tissue samples for selection of tamoxifen therapy. ( Ahn, S; Jung, D; Kim, S; Lee, D; Lee, H; Park, KH; Park, S; Wang, HY, 2014) |
| "20-30% of breast cancer patients have HER2 overexpression, and they usually show poor recovery rate." | 1.40 | Quantitative RT-PCR assay of HER2 mRNA expression in formalin-fixed and paraffin-embedded breast cancer tissues. ( Ahn, S; Cho, Y; Jung, D; Kim, S; Kim, SI; Lee, D; Lee, H; Park, KH; Park, S; Wang, HY, 2014) |
| "LOH at the CYP2D6 locus is common in breast cancer, resulting in potential misclassification of germline CYP2D6 genotypes." | 1.40 | Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies. ( Ames, MM; Brauch, HB; Burgues, O; Chen, D; Cox, NJ; Goetz, MP; Gomez, HL; Gonzalez-Angulo, AM; Ingle, JN; Kalari, KR; Kuffel, MJ; Miller, VA; Nakamura, Y; Perou, CM; Ratain, MJ; Ross, JS; Safgren, SL; Silva, GO; Stephens, PJ; Suman, VJ; Sun, JX; Yelensky, R, 2014) |
| "Grade 2 breast carcinomas do not form a uniform prognostic group." | 1.39 | [Simplified, low-cost gene expression profiling for the prediction of outcome in breast cancer based on routine histologic specimens]. ( Ács, B; Ágoston, E; Győrffy, B; Harsányi, L; Kulka, J; Li, Q; Swanton, C; Szállási, Z; Szász, AM; Székely, B; Szendrői, M; Szittya, L; Sztupinszki, Z; Tímár, J; Tőkés, AM, 2013) |
| "In the first study on breast cancer samples, we assessed whether a human epidermal growth factor receptor (HER) 2 score based on immunohistochemistry (IHC) could be reproduced with RPPA." | 1.39 | Multiple protein analysis of formalin-fixed and paraffin-embedded tissue samples with reverse phase protein arrays. ( Arbogast, S; Assadi, M; Breitinger, E; Essioux, L; Farfsing, A; Gierke, B; Jarutat, T; Lamerz, J; Langen, H; Paul, H; Pawlak, M; Schindler, T; Templin, MF; Venturi, M, 2013) |
| "FFPE specimens from 290 female breast cancer patients were used for further RNA extraction; ESR1 and PGR were measured using 203 matched FFPE and FF specimens and normalized to these reference genes." | 1.39 | Establishment of a standardized gene-expression analysis system using formalin-fixed, paraffin-embedded, breast cancer specimens. ( Fu, P; Fujiwara, S; Honda, Y; Ibusuki, M; Iwase, H; Iyama, K; Yamamoto, S; Yamamoto, Y, 2013) |
| "Microcalcifications are an early mammographic sign of breast cancer and a target for stereotactic breast needle biopsy." | 1.39 | Development and comparative assessment of Raman spectroscopic classification algorithms for lesion discrimination in stereotactic breast biopsies with microcalcifications. ( Barman, I; Dasari, RR; Dingari, NC; Fitzmaurice, M; Galindo, LH; Klein, N; Liu, W; McGee, S; Plecha, D; Saha, A, 2013) |
| "Infiltrating lobular breast cancer (ILBC) is a tumor-biologically distinct breast cancer subtype." | 1.39 | Oncogenic PIK3CA mutations in lobular breast cancer progression. ( Christgen, H; Christgen, M; Heil, C; Krech, T; Kreipe, H; Länger, F; Lehmann, U; Noskowicz, M; Schipper, E, 2013) |
| "Thirty-nine cases of invasive breast carcinoma containing ≥30% tumor were classified as positive or negative for HER2 by IHC, FISH, or both." | 1.39 | Droplet digital PCR measurement of HER2 copy number alteration in formalin-fixed paraffin-embedded breast carcinoma tissue. ( Belgrader, P; Brown, AS; Hindson, BJ; Koehler, R; Regan, JF; Tanner, SC, 2013) |
| "However, breast cancer is a diverse disease and little is known about the relationships between miRNA expression, clinical outcome and tumour subtype." | 1.38 | Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue. ( Ali, HR; Bardwell, H; Blows, F; Caldas, C; Dawson, SJ; Jones, J; Pharoah, P; Quesne, JL; Warren, J, 2012) |
| "This results in a breast cancer mutational profile consistent with previous studies and revealing potentially important functional mutations." | 1.38 | Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens. ( Bao, L; Frazer, KA; Harismendy, O; Jung, H; Messer, K; Parker, BA; Pierce, JP; Schwab, RB; Smith, EN; Voest, E; Wang, X; Yost, SE, 2012) |
| "Ten palpable invasive breast carcinomas were resected and underwent immediate gross evaluation." | 1.38 | Delay to formalin fixation alters morphology and immunohistochemistry for breast carcinoma. ( Khoury, T, 2012) |
| "In contrast, 85% of breast cancer cases had loss of or decreased HLA class I expression." | 1.38 | Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue: unusually high frequency of down-regulation in breast cancer tissues. ( Asanuma, H; Hasegawa, T; Hirohashi, Y; Kanaseki, T; Nakazawa, E; Sato, N; Tamura, Y; Torigoe, T; Yamamoto, E, 2012) |
| "The eligibility of breast cancer patients for human epidermal growth factor receptor 2 (HER2)-directed therapies is determined by the HER2 gene amplification and/or HER2 protein overexpression status of the breast tumor as determined by in situ hybridization (ISH) or immunohistochemistry (IHC), respectively." | 1.38 | A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections. ( Bai, I; Bieniarz, C; Brunhoeber, P; Grogan, TM; Kelly, BD; Nitta, H; Padilla, M; Ranger-Moore, J; Singh, S; Tsuda, H; Wick, N, 2012) |
| "A series of 93 breast cancer specimens with known time-to-fixation represented in a tissue microarray and a second series of 25 matched pairs of core needle biopsies and breast cancer resections were used to evaluate changes in antigenicity as a function of cold ischemic time." | 1.38 | Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues. ( Anagnostou, V; England, AM; Hicks, DG; Kluger, Y; Neumeister, VM; Parisi, F; Rimm, DL; Siddiqui, S; Vassilakopoulou, M; Zarrella, ER, 2012) |
| "It has been a challenge to determine breast cancer clonality accurately." | 1.38 | Analysis of gene alterations of mitochondrial DNA D-loop regions to determine breast cancer clonality. ( Kadowaki, T; Kumaki, N; Masuda, S; Osamura, RY; Takekoshi, S; Tang, X; Tokuda, Y; Yoshimura, S, 2012) |
| "The heterogeneity of breast cancer requires the discovery of more incisive molecular tools that better define disease progression and prognosis." | 1.37 | Differential proteomic analysis of late-stage and recurrent breast cancer from formalin-fixed paraffin-embedded tissues. ( Bateman, NW; Bhargava, R; Conrads, TP; Darfler, MM; Hood, BL; Hooke, JA; Kovatich, AJ; Krizman, DB; Sun, M, 2011) |
| "Expression of the breast cancer biomarkers ESR1, PGR, and HER2 was measured in a total of 501 FFPE tissue samples from 167 breast carcinomas, which had been stored for up to 21 years." | 1.37 | Quantitative determination of estrogen receptor, progesterone receptor, and HER2 mRNA in formalin-fixed paraffin-embedded tissue--a new option for predictive biomarker assessment in breast cancer. ( Altmann, G; Bohmann, K; Denkert, C; Dietel, M; Euting, H; Hennig, G; Kristiansen, G; Kronenwett, R; Müller, BM; Petry, C; Roth, C; Weber, K; Weichert, W; Winzer, KJ, 2011) |
| "LTD]) using 9 breast cancer specimens, which were fixed in formalin for various durations after the surgical extirpation or biopsy." | 1.36 | [Comparison of two HER-2 FISH kits on formalin-fixed paraffin-embedded tissues: signal detection and simple procedure]. ( Hidaka, E; Honda, T; Kumagai, T; Matsuda, K; Sano, K; Shimojyo, Y; Uehara, T; Uhara, M, 2010) |
| "For every newly diagnosed breast cancer HER2 testing is a standard routine procedure." | 1.36 | [HER2 ASCO guidelines. The answer to everything?]. ( Burandt, E; Sauter, G, 2010) |
| "Core-cuts taken from surgical breast cancer specimens immediately after resection (sample A) and after routine X-ray of the excised tumour (sample B) were formalin-fixed and paraffin-embedded and compared to the routinely fixed resection specimen (sample C)." | 1.36 | Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer. ( A'hern, R; Detre, S; Dowsett, M; Hills, MJ; Macneill, FA; Nerurkar, A; Osin, P; Pinhel, IF; Salter, J; Smith, IE, 2010) |
| "Expression of the 8 breast cancer genes was detected in 81%-100% of tumor tissues and 21%-100% of normal tissues." | 1.36 | Automated extraction of DNA and RNA from a single formalin-fixed paraffin-embedded tissue section for analysis of both single-nucleotide polymorphisms and mRNA expression. ( Brauch, H; Eichelbaum, M; Fritz, P; Gehrmann, M; Hennig, G; Schroth, W; Schwab, M; Stropp, U, 2010) |
| "The differentially expressed genes in breast cancer found in our study were biologically meaningful." | 1.36 | Analyses and interpretation of whole-genome gene expression from formalin-fixed paraffin-embedded tissue: an illustration with breast cancer tissues. ( Ahsan, H; Argos, M; Jasmine, F; Kibriya, MG; Paul-Brutus, RM; Roy, S, 2010) |
| "Ten palpable invasive breast cancers were resected and underwent immediate gross evaluation." | 1.35 | Delay to formalin fixation effect on breast biomarkers. ( Chandrasekhar, R; Hwang, H; Khoury, T; Kulkarni, S; Sait, S; Tan, D; Wilding, G, 2009) |
| "These procedures were tested using four breast cancer microarrays." | 1.34 | Direct detection of herceptin/trastuzumab binding on breast tissue sections. ( Blanc, V; Eliason, JF; Glazyrin, A; Shen, X, 2007) |
| "DNA and RNA were extracted from 20 breast cancer samples that had been routinely fixed in Bouin's fixative." | 1.33 | DNA and RNA obtained from Bouin's fixed tissues. ( Bonin, S; Petrera, F; Rosai, J; Stanta, G, 2005) |
| "Almost one third of invasive breast carcinomas overexpress the HER-2/neu protein, so the use of the anti-HER-2/neu monoclonal antibody Herceptin (trastuzumab) to block the protein has become important in the management of and in prolonging the survival for patients with metastatic breast cancer." | 1.33 | HER-2 status in breast cancer: correlation of gene amplification by FISH with immunohistochemistry expression using advanced cellular imaging system. ( Ayata, G; Baiyee, D; Ciampa, A; Edmiston, K; Khan, A; Wallace, J; Wertheimer, M; Xu, B, 2006) |
| "A multitude of breast cancer mRNA profiling studies has stratified breast cancer and defined gene sets that correlate with outcome." | 1.33 | Classification of breast cancer using genetic algorithms and tissue microarrays. ( Camp, RL; Cregger, M; Dolled-Filhart, M; Harigopal, M; Jirström, K; Rimm, DL; Rydén, L, 2006) |
| "DNA was extracted from 70 FFPE breast cancer tissue specimens." | 1.32 | Evaluation of oligonucleotide arrays for sequencing of the p53 gene in DNA from formalin-fixed, paraffin-embedded breast cancer specimens. ( Bhardwaj, T; Cooper, M; Kandel, RA; Li, SQ; Rohan, T, 2004) |
| "Unselected stage I, II, and III breast cancer patients (N = 900) were tested for HER-2/neu gene amplification by FISH in paraffin-embedded, formalin-fixed archival material." | 1.31 | Assessment of methods for tissue-based detection of the HER-2/neu alteration in human breast cancer: a direct comparison of fluorescence in situ hybridization and immunohistochemistry. ( Dandekar, S; Pauletti, G; Peng, H; Ramos, L; Rong, H; Seshadri, R; Slamon, DJ, 2000) |
| "We previously found that, in ductal breast cancer, uPA mRNA is highly expressed by myofibroblasts surrounding invasively growing cancer cells." | 1.31 | Urokinase plasminogen activator is localized in stromal cells in ductal breast cancer. ( Danø, K; Duun, S; Johnsen, M; Nielsen, BS; Rank, F; Rygaard, J; Sehested, M; Timshel, S, 2001) |
| "We evaluated 173 consecutive breast carcinomas for c-erbB-2 using a combination of immunohistochemistry (IHC) with a commercial polyclonal antibody (Nitirei) and dual-color fluorescence in situ hybridization (FISH) using the c-erbB-2-specific probe and the chromosome 17 centromere-specific probe from Vysis (Downers Grove, IL) and compared the results with the histologic characteristics of intraductal spread, cancer invasion, and intratumoral heterogeneity." | 1.31 | Protein overexpression and gene amplification of c-erbB-2 in breast carcinomas: a comparative study of immunohistochemistry and fluorescence in situ hybridization of formalin-fixed, paraffin-embedded tissues. ( Kobayashi, M; Nakanishi, I; Oda, Y; Ooi, A, 2002) |
| "Although breast cancer tissues were used in this initial study, the protocol is applicable to other cancer tissues as well." | 1.30 | Sequential flow cytometry and fluorescence in situ hybridization for the study of formalin-fixed, paraffin-embedded breast cancer cells. ( Barker, BE; Ferreira, K; Huth, A; Mark, HF; Mark, S; Rausch, ME; Santoro, K; Taylor, WM; Zolnierz, K, 1998) |
| "In human breast cancer SK-BR-3 cells that do not express SATB1, at least one such sequence was found not anchored onto the nuclear matrix." | 1.30 | The genomic sequences bound to special AT-rich sequence-binding protein 1 (SATB1) in vivo in Jurkat T cells are tightly associated with the nuclear matrix at the bases of the chromatin loops. ( Cai, S; de Belle, I; Kohwi-Shigematsu, T, 1998) |
| "We studied 82 routine PT breast tumors by our assay and used a univariate flow DNA histogram based on fresh biopsy tissue for comparison." | 1.30 | Flow cytometric DNA analysis with cytokeratin gating of formalin-fixed deparaffinized breast cancer nuclei. ( McCormick, SR; Peters, AA; Schrauth, JB, 1998) |
| "Medullary carcinomas are high grade and poorly differentiated tumours with syncytial typical pattern, and prognosis unexpectedly better than that in high grade breast carcinomas." | 1.30 | E-cadherin and beta-catenin expression in breast medullary carcinomas. ( Allasia, C; Andrac, L; Bonnier, P; Charpin, C; Crebassa, B; Dorel, M; Garcia, S; Lavaut, MN, 1999) |
| "A series of 90 cases of human breast carcinoma was analyzed and the staining was assessed using a semiquantitative microscopic scoring method and by assessment of the percentage of nuclei showing positive staining." | 1.29 | A new immunohistochemical antibody for the assessment of estrogen receptor status on routine formalin-fixed tissue samples. ( Bell, J; Blamey, RW; Cannon, P; Elston, CW; Goulding, H; Nicholson, R; Pearson, D; Pinder, S; Robertson, JF; Snead, D, 1995) |
| "One hundred thirty-two breast carcinomas were studied retrospectively using formalin fixed, paraffin embedded archival tissues on which S-LI and S-flow had been obtained originally." | 1.29 | Assessment of proliferating cell nuclear antigen (PCNA) in breast cancer using anti-PCNA PC10 and 19A2: correlation with 5-bromo-2'-deoxyuridine or tritiated thymidine labeling and flow cytometric analysis. ( He, W; Hughes, J; Koehm, S; Meyer, JS; Scrivner, DL, 1994) |
| "Twelve of 51 random invasive bladder cancers (24%) had abnormal expression of the RB gene, as determined by immunohistochemistry." | 1.29 | Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti-RB antibodies. ( Benedict, WF; Geradts, J; Hu, SX; Lincoln, CE; Xu, HJ, 1994) |
| "Objective grading of breast cancer by morphometry has been suggested for improving the precision of the prognostic prediction." | 1.29 | The influence of tissue processing on quantitative histopathology in breast cancer. ( Ladekarl, M, 1994) |
| "A series of 94 cases of breast cancer were analysed and the results were compared with assessment by oestrogen receptor immunocytochemical assay performed on frozen section." | 1.29 | Methodology of immunohistological detection of oestrogen receptor in human breast carcinoma in formalin-fixed, paraffin-embedded tissue: a comparison with frozen section methodology. ( Bell, JA; Blamey, RW; Dixon, AR; Ellis, IO; Elston, CW; Nicholson, RI; Snead, DR, 1993) |
| "In a prospective series of 22 breast carcinomas we found that 82% (18/22) were oestrogen receptor positive." | 1.29 | [Analysis of estrogen receptors in mammary carcinomas. Is immunocytochemical determination after formalin fixation sufficient?]. ( Aasmundstad, T; Haugen, OA; Johannesen, E; Nervik, I; Ytterhus, B, 1993) |
| "DNA content of 35 cases of breast carcinoma of varying histologic types and nuclear grades was analyzed by flow cytometry and image analysis in both fresh and formalin-fixed, paraffin-embedded tissue." | 1.29 | Comparison of flow and image cytometry for DNA content analysis of fresh and formalin-fixed, paraffin-embedded tissue in breast carcinoma. ( Chen, TL; Luo, I; Mikhail, N; Raska, K; Rasková, J, 1995) |
| "Breast carcinoma is frequently associated with nonrandom chromosomal aberrations, but their identification by standard cytogenetics (SC) is often limited by technical difficulties." | 1.29 | Genetic heterogeneity of primary and metastatic breast carcinoma defined by fluorescence in situ hybridization. ( Ho, JP; Quan, DE; Simpson, JF; Slovak, ML, 1996) |
| "Experimental therapeutic regimens for breast cancer include strategies to block the activity of specific oncogenes." | 1.29 | Plasma membrane phosphotyrosine, Her2-NEU, and epidermal growth factor receptor in human breast cancer. A comparative study. ( Fenoglio-Preiser, CM; Heffelfinger, SC; Lower, EE; Miller, MA, 1996) |
| "In 77 breast carcinoma studied simultaneously on paraffin sections and EIA, the concordance was 74% for ER and 79." | 1.28 | [Human breast cancer embedded in paraffin, fixed in Bouin's fluid. Immunohistochemical analysis of estrogen and progesterone receptors]. ( Boudaoura, T; Hassoun, J; Jacquemier, J; Martin, PM; Torrente, M, 1991) |
| "Emphasis on early detection of breast carcinomas has increased the number of instances in which an insufficient amount of tissue is available for biochemical estrogen receptor (ER) assay." | 1.28 | Quantification of estrogen receptors on paraffin-embedded tumors by image analysis. ( Bacus, S; Bailey, A; Battifora, H; Esteban, JM; Warsi, Z, 1991) |
| "Thirty-two cases of infiltrating ductal breast carcinoma were stained with a monoclonal anti-OR antibody (H222), using a standard streptavidin-biotin method, following pretreatment with pronase." | 1.28 | Oestrogen receptor staining of paraffin-embedded breast carcinomas following short fixation in formalin: a comparison with cytosolic and frozen section receptor analyses. ( Leong, AS; Raymond, WA, 1990) |
| "The PR content of breast cancer tissue was investigated in 170 cases." | 1.28 | Immunohistochemical detection of progesterone receptor in formalin-fixed and paraffin-embedded breast cancer tissue using a monoclonal antibody. ( Bolte, A; Conradt, B; Moll, W; Scharl, A; Vierbuchen, M; Würz, H, 1990) |
| "In 111 breast cancer specimens studied simultaneously by a dextran-coated charcoal (DCC) assay and the paraffin section method, agreement on receptor status was found in 101 (91%) specimens." | 1.27 | Immunohistochemical demonstration of estrogen receptors (ER) in formalin-fixed, paraffin-embedded human breast cancer tissue by use of a monoclonal antibody to ER. ( Andersen, J; Orntoft, TF; Poulsen, HS, 1988) |
| " Other advantages of formalinized cells over antigens prepared by homogenizing tumour tissue include a greater degree of inhibition and the ability to demonstrate a dose-response relationship between the ratio of leucocytes:tumour cells and the migration index." | 1.25 | Formalinized tumour cells in the leucocyte migration inhibition test. ( Cochran, AJ; Grant, RM; Hoyle, DE; Mackie, RM; Ross, CE, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 19 (5.57) | 18.7374 |
| 1990's | 52 (15.25) | 18.2507 |
| 2000's | 81 (23.75) | 29.6817 |
| 2010's | 172 (50.44) | 24.3611 |
| 2020's | 17 (4.99) | 2.80 |
| Authors | Studies |
|---|---|
| Burns, JA | 1 |
| Li, Y | 5 |
| Cheney, CA | 1 |
| Ou, Y | 1 |
| Franlin-Pfeifer, LL | 1 |
| Kuklin, N | 1 |
| Zhang, ZQ | 1 |
| Pellicciari, C | 1 |
| Mangiarotti, R | 1 |
| Bottone, MG | 1 |
| Danova, M | 1 |
| Wang, E | 1 |
| Kono, T | 1 |
| Nishida, M | 1 |
| Inagaki, N | 1 |
| Tanaka, Y | 1 |
| Yoneda, M | 1 |
| Kasai, S | 1 |
| Graham, ML | 1 |
| Bunn, PA | 1 |
| Jewett, PB | 1 |
| Gonzalez-Aller, C | 1 |
| Horwitz, KB | 1 |
| Loughman, T | 1 |
| Barron, S | 1 |
| Wang, CA | 1 |
| Dynoodt, P | 1 |
| Fender, B | 1 |
| Lopez-Ruiz, C | 1 |
| Stapleton, S | 1 |
| Fabre, A | 1 |
| Quinn, C | 1 |
| Nodin, B | 1 |
| Jirström, K | 3 |
| Razmara, F | 1 |
| O'Grady, A | 1 |
| Baird, AM | 1 |
| Gray, SG | 1 |
| Freixo, A | 1 |
| Moelans, CB | 1 |
| van Diest, PJ | 3 |
| Duffy, MJ | 1 |
| O'Leary, D | 1 |
| Crown, J | 1 |
| Bracken, AP | 1 |
| Gallagher, WM | 2 |
| Boissière-Michot, F | 2 |
| Mollevi, C | 1 |
| Baecker, V | 1 |
| Crapez, E | 1 |
| Jacot, W | 1 |
| Leiloglou, M | 1 |
| Kedrzycki, MS | 1 |
| Chalau, V | 1 |
| Chiarini, N | 1 |
| Thiruchelvam, PTR | 1 |
| Hadjiminas, DJ | 1 |
| Hogben, KR | 1 |
| Rashid, F | 1 |
| Ramakrishnan, R | 1 |
| Darzi, AW | 1 |
| Leff, DR | 1 |
| Elson, DS | 1 |
| Ondracek, RP | 1 |
| Chen, J | 3 |
| Marosy, B | 1 |
| Szewczyk, S | 1 |
| Medico, L | 1 |
| Mohan, AS | 1 |
| Nair, P | 1 |
| Pratt, R | 1 |
| Roh, JM | 1 |
| Khoury, T | 6 |
| Carpten, J | 1 |
| Kushi, LH | 1 |
| Palmer, JR | 1 |
| Doheny, K | 1 |
| Davis, W | 1 |
| Higgins, MJ | 1 |
| Yao, S | 1 |
| Ambrosone, CB | 2 |
| Li, F | 1 |
| Hooper, AT | 1 |
| Golas, J | 1 |
| Chang, CB | 1 |
| Neubert, H | 1 |
| King, L | 1 |
| Alinezhadi, M | 1 |
| Makvandi, M | 2 |
| Kaydani, GA | 1 |
| Jazayeri, SN | 1 |
| Charostad, J | 1 |
| Talaeizadeh, AT | 1 |
| Angali, KA | 1 |
| Mamede, AP | 1 |
| Santos, IP | 1 |
| Batista de Carvalho, ALM | 1 |
| Figueiredo, P | 1 |
| Silva, MC | 1 |
| Marques, MPM | 1 |
| Batista de Carvalho, LAE | 1 |
| Kim, K | 1 |
| Ylaya, K | 1 |
| Perry, C | 1 |
| Lee, MY | 1 |
| Kim, JW | 1 |
| Chung, JY | 1 |
| Hewitt, SM | 3 |
| Zhang, R | 3 |
| Liu, C | 3 |
| Wang, P | 3 |
| Su, Y | 2 |
| Dai, J | 2 |
| Marczyk, M | 2 |
| Fu, C | 2 |
| Lau, R | 2 |
| Du, L | 2 |
| Trevarton, AJ | 2 |
| Sinn, BV | 2 |
| Gould, RE | 2 |
| Pusztai, L | 3 |
| Hatzis, C | 2 |
| Symmans, WF | 3 |
| Yamashita, H | 1 |
| Hatanaka, KC | 1 |
| Yamagishi, K | 1 |
| Saito, Y | 1 |
| Hamasaki, K | 1 |
| Taniguchi, M | 1 |
| Okumura, A | 1 |
| Nange, A | 1 |
| Matsuno, Y | 1 |
| Hatanaka, Y | 3 |
| Miki, Y | 1 |
| Iwabuchi, E | 1 |
| Suzuki, T | 1 |
| Giampà, M | 1 |
| Andersen, MK | 1 |
| Krossa, S | 1 |
| Denti, V | 1 |
| Smith, A | 1 |
| Moestue, SA | 1 |
| Bhagwate, AV | 1 |
| Liu, Y | 1 |
| Winham, SJ | 1 |
| McDonough, SJ | 1 |
| Stallings-Mann, ML | 1 |
| Heinzen, EP | 1 |
| Davila, JI | 1 |
| Vierkant, RA | 1 |
| Hoskin, TL | 1 |
| Frost, M | 1 |
| Carter, JM | 1 |
| Radisky, DC | 1 |
| Cunningham, JM | 1 |
| Degnim, AC | 1 |
| Wang, C | 1 |
| van Kooten, XF | 1 |
| Petrini, LFT | 1 |
| Kashyap, A | 1 |
| Voith von Voithenberg, L | 1 |
| Bercovici, M | 1 |
| Kaigala, GV | 1 |
| Pennock, ND | 1 |
| Jindal, S | 1 |
| Horton, W | 1 |
| Sun, D | 1 |
| Narasimhan, J | 1 |
| Carbone, L | 1 |
| Fei, SS | 1 |
| Searles, R | 1 |
| Harrington, CA | 1 |
| Burchard, J | 1 |
| Weinmann, S | 1 |
| Schedin, P | 1 |
| Xia, Z | 1 |
| Turnbull, AK | 1 |
| Selli, C | 1 |
| Martinez-Perez, C | 1 |
| Fernando, A | 1 |
| Renshaw, L | 1 |
| Keys, J | 1 |
| Figueroa, JD | 1 |
| He, X | 1 |
| Tanioka, M | 1 |
| Munro, AF | 1 |
| Murphy, L | 1 |
| Fawkes, A | 1 |
| Clark, R | 1 |
| Coutts, A | 1 |
| Perou, CM | 3 |
| Carey, LA | 1 |
| Dixon, JM | 1 |
| Sims, AH | 1 |
| Do, M | 1 |
| Kim, H | 2 |
| Yeo, I | 1 |
| Lee, J | 2 |
| Park, IA | 1 |
| Ryu, HS | 1 |
| Kim, Y | 1 |
| Conceição, ALC | 1 |
| Perlich, J | 1 |
| Haas, S | 1 |
| Funari, SS | 1 |
| Kennedy, JJ | 1 |
| Whiteaker, JR | 1 |
| Kennedy, LC | 1 |
| Bosch, DE | 1 |
| Lerch, ML | 1 |
| Schoenherr, RM | 1 |
| Zhao, L | 2 |
| Lin, C | 1 |
| Chowdhury, S | 1 |
| Kilgore, MR | 1 |
| Allison, KH | 1 |
| Hoofnagle, AN | 1 |
| Baird, GS | 1 |
| Paulovich, AG | 1 |
| Varga, Z | 1 |
| Lebeau, A | 1 |
| Bu, H | 2 |
| Hartmann, A | 1 |
| Penault-Llorca, F | 1 |
| Guerini-Rocco, E | 1 |
| Schraml, P | 1 |
| Symmans, F | 1 |
| Stoehr, R | 1 |
| Teng, X | 1 |
| Turzynski, A | 1 |
| von Wasielewski, R | 1 |
| Gürtler, C | 2 |
| Laible, M | 2 |
| Schlombs, K | 2 |
| Joensuu, H | 2 |
| Keller, T | 1 |
| Sinn, P | 1 |
| Sahin, U | 2 |
| Bartlett, J | 2 |
| Viale, G | 3 |
| Iddawela, M | 2 |
| Rueda, O | 1 |
| Eremin, J | 1 |
| Eremin, O | 1 |
| Cowley, J | 1 |
| Earl, HM | 2 |
| Caldas, C | 4 |
| Alberts, D | 2 |
| Pottier, C | 1 |
| Smargiasso, N | 2 |
| Baiwir, D | 2 |
| Mazzucchelli, G | 2 |
| Delvenne, P | 1 |
| Kriegsmann, M | 2 |
| Kazdal, D | 1 |
| Warth, A | 1 |
| De Pauw, E | 2 |
| Longuespée, R | 2 |
| Clark, BZ | 1 |
| Yoest, JM | 1 |
| Onisko, A | 1 |
| Dabbs, DJ | 2 |
| Wang, X | 2 |
| Wu, Y | 2 |
| Song, X | 1 |
| Sun, C | 1 |
| Wu, C | 1 |
| Feng, H | 1 |
| Lawler, K | 1 |
| Papouli, E | 1 |
| Naceur-Lombardelli, C | 1 |
| Mera, A | 1 |
| Ougham, K | 1 |
| Tutt, A | 2 |
| Kimbung, S | 1 |
| Hedenfalk, I | 1 |
| Zhan, J | 1 |
| Zhang, H | 2 |
| Buus, R | 1 |
| Dowsett, M | 5 |
| Ng, T | 1 |
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| Gillett, CE | 2 |
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| Luo, Y | 1 |
| Liu, X | 1 |
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| Ren, X | 1 |
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| Bartsch, H | 1 |
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| Petat-Dutter, K | 1 |
| Bonin, M | 1 |
| Kahlert, S | 1 |
| Harbeck, N | 2 |
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| Seeger, H | 1 |
| Fehm, T | 1 |
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| Hartmann, K | 1 |
| Schmidt, M | 1 |
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| Sorrelle, N | 1 |
| Ganguly, D | 1 |
| Dominguez, ATA | 1 |
| Zhang, Y | 1 |
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| MacNeill, FA | 2 |
| Dodson, A | 1 |
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| Samarbafzadeh, A | 1 |
| Talaei-Zadeh, A | 1 |
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| Chen, Y | 1 |
| Shen, Q | 1 |
| White, SL | 1 |
| Gokmen-Polar, Y | 1 |
| Badve, S | 1 |
| Goodman, LJ | 1 |
| Zakrzewski, F | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| "A Randomized Multicenter Phase II Trial to Evaluate the Effectiveness of Selective Neoadjuvant Treatment According to Immunohistochemical Subtype for HER2 Negative Breast Cancer Patients"[NCT00432172] | Phase 2 | 189 participants (Actual) | Interventional | 2007-04-24 | Completed | ||
| Phase 2 Study of Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory CD30 Positive T-cell Lymphoma[NCT05313243] | Phase 2 | 43 participants (Anticipated) | Interventional | 2023-07-10 | Recruiting | ||
| Tumor Mutational Patterns and Infiltrating Lymphocyte Density in Young and Old Patients With Breast Cancer[NCT04033965] | 345 participants (Actual) | Observational | 1997-09-03 | Completed | |||
| A Phase III Study to Evaluate Letrozole as Adjuvant Endocrine Therapy for Postmenopausal Women With Receptor (ER and/or PgR) Positive Tumors[NCT00004205] | Phase 3 | 8,028 participants (Actual) | Interventional | 1998-03-31 | Completed | ||
| Genetic Mutations and Response to Treatment in Gallbladder Cancer: A Hospital Based Cohort Study[NCT05404347] | 100 participants (Anticipated) | Observational [Patient Registry] | 2018-01-01 | Recruiting | |||
| Phase II Trial of Pemetrexed and Bevacizumab for Recurrent Ovarian and Primary Peritoneal Carcinoma[NCT00868192] | Phase 2 | 38 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Clinical Response Rate was measured according to the Response Evaluation Criteria in Solid Tumors (RECIST) Criteria for target lesions before surgery: Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR. (NCT00432172)
Timeframe: Up to week 24
| Intervention | Participants (Count of Participants) |
|---|---|
| Group 1 (Luminal A) Standard Treatment | 31 |
| Group 1 (Luminal A) Selective Treatment | 23 |
| Group 2 (Basal) Standard Treatment | 32 |
| Group 2 (Basal) Selective Treatment | 36 |
"Overall response rate = complete response + partial response~Complete response = disappearance of all target and non-target lesions and no evidence of new lesions documented by two disease assessments at least 4 weeks apart.~Partial response = at least a 30% decrease in the sum of the longest dimensions (LD) of all target measurable lesions taking as reference the baseline sum of LD. There can be non unequivocal progression of non-target lesions and no new lesions." (NCT00868192)
Timeframe: 6 months
| Intervention | percentage of participants (Number) |
|---|---|
| Pemetrexed and Bevacizumab | 41 |
OS = observed length of time from entry into the study to death or date of last contact (NCT00868192)
Timeframe: 12 months
| Intervention | percentage of participants (Number) |
|---|---|
| Pemetrexed and Bevacizumab | 79 |
OS = observed length of time from entry into the study to death or date of last contact (NCT00868192)
Timeframe: Median follow-up was 25.7 months (range 3.0-47.2 months)
| Intervention | months (Median) |
|---|---|
| Pemetrexed and Bevacizumab | 25.7 |
PFS = Period from study entry until disease progression, death, or date of last contact (NCT00868192)
Timeframe: 6 months
| Intervention | percentage of participants (Number) |
|---|---|
| Pemetrexed and Bevacizumab | 56 |
PFS = Period from study entry until disease progression, death, or date of last contact (NCT00868192)
Timeframe: Median follow-up was 25.7 months (range 3.0-47.2 months)
| Intervention | months (Median) |
|---|---|
| Pemetrexed and Bevacizumab | 7.9 |
A CA-125 response was defined as at least a 50% reduction in CA-125 levels from a pretreatment sample following guidelines described by the Gynecological Cancer Intergroup. (NCT00868192)
Timeframe: 6 months
| Intervention | participants (Number) | ||
|---|---|---|---|
| 50% CA-125 response | 75% CA-125 response | No CA-125 response | |
| Pemetrexed and Bevacizumab | 17 | 8 | 2 |
OS = observed length of time from entry into the study to death or date of last contact (NCT00868192)
Timeframe: Median follow-up was 25.7 months (range 3.0-47.2 months)
| Intervention | months (Median) | ||
|---|---|---|---|
| Platinum-free interval of <6 months | Platinum-free interval of 6-12 months | Platinum-free interval of >12 months | |
| Pemetrexed and Bevacizumab | 16.7 | 24.9 | 28.0 |
PFS = Period from study entry until disease progression, death, or date of last contact (NCT00868192)
Timeframe: Median follow-up was 25.7 months (range 3.0-47.2 months)
| Intervention | months (Median) | ||
|---|---|---|---|
| Platinum-free interval of <6 months | Platinum-free interval of 6-12 months | Platinum-free interval of >12 months | |
| Pemetrexed and Bevacizumab | 6.7 | 4.7 | 16.8 |
As measured by RECIST criteria (NCT00868192)
Timeframe: 6 months
| Intervention | participants (Number) | |||
|---|---|---|---|---|
| Complete response | Partial response | Stable disease | Progressive disease | |
| Pemetrexed and Bevacizumab | 0 | 14 | 18 | 2 |
Detailed serious adverse events and other adverse events are shown in the adverse event module of the results. (NCT00868192)
Timeframe: 6 months
| Intervention | percentage of participants (Number) | ||||
|---|---|---|---|---|---|
| Grade 3/4 hematologic toxicity | Most common non-hematologic toxicity - fatigue | Grade 3 renal toxicity | Gastrointestinal toxicity | Subsequently developed hematologic malignancies | |
| Pemetrexed and Bevacizumab | 53 | 94 | 6 | 91 | 6 |
9 reviews available for formaldehyde and Breast Neoplasms
| Article | Year |
|---|---|
Delay to Formalin Fixation (Cold Ischemia Time) Effect on Breast Cancer Molecules.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cold Ischemia; Female; Formaldehyde; Humans; Tissue Fixation | 2018 |
Antigen retrieval, blocking, detection and visualisation systems in immunohistochemistry: a review and practical evaluation of tyramide and rolling circle amplification systems.
Topics: Animals; Antibodies; Antigens; Antigens, CD20; Breast Neoplasms; Colonic Neoplasms; Female; Formalde | 2014 |
The effects of under 6 hours of formalin fixation on hormone receptor and HER2 expression in invasive breast cancer: a systematic review.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Humans; Receptor, ErbB-2; Receptors, Estr | 2014 |
[Development of a Dual Detection Method with Fluorescence In Situ Hybridization and Immunostaining on Formalin-Fixed Paraffin-Embedded Tissue Sections--Molecular Pathological Detection Techniques and Their Applications to Pathological Diagnosis].
Topics: Animals; Breast Neoplasms; Formaldehyde; Humans; In Situ Hybridization, Fluorescence; Paraffin; Path | 2015 |
Guidelines for human epidermal growth factor receptor 2 testing: biologic and methodologic considerations.
Topics: Breast Neoplasms; Female; Formaldehyde; Gene Amplification; Genes, erbB-2; Guidelines as Topic; Huma | 2009 |
Expression profiling of archival tumors for long-term health studies.
Topics: Breast Neoplasms; Colorectal Neoplasms; Female; Fixatives; Follow-Up Studies; Formaldehyde; Gene Exp | 2012 |
Technology insight: Application of molecular techniques to formalin-fixed paraffin-embedded tissues from breast cancer.
Topics: Biopsy; Breast Neoplasms; DNA, Neoplasm; Female; Fixatives; Formaldehyde; Gene Expression Profiling; | 2005 |
Molecular subtyping of breast cancer: opportunities for new therapeutic approaches.
Topics: Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Formaldehyde; Gene Expression Pro | 2007 |
[Role of the pathologist in management of familial cancers].
Topics: Acetic Acid; Breast Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Cytogenetic Analysis; | 2001 |
5 trials available for formaldehyde and Breast Neoplasms
| Article | Year |
|---|---|
An international reproducibility study validating quantitative determination of ERBB2, ESR1, PGR, and MKI67 mRNA in breast cancer using MammaTyper®.
Topics: Biomarkers, Tumor; Breast Neoplasms; Estrogen Receptor alpha; Female; Formaldehyde; Gene Expression | 2017 |
Evaluation of two highly-multiplexed custom panels for massively parallel semiconductor sequencing on paraffin DNA.
Topics: Breast Neoplasms; DNA, Neoplasm; Female; Formaldehyde; Genotype; High-Throughput Nucleotide Sequenci | 2015 |
The Genomic Grade Assay Compared With Ki67 to Determine Risk of Distant Breast Cancer Recurrence.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Proliferation; Disease-Free Survival; Female; Fixatives; F | 2016 |
Gene expression patterns in formalin-fixed, paraffin-embedded core biopsies predict docetaxel chemosensitivity in breast cancer patients.
Topics: Antineoplastic Agents; Biopsy; Breast Neoplasms; Chemotherapy, Adjuvant; Docetaxel; Female; Fixative | 2008 |
Axillary lymph node status in carcinoma of the breast.
Topics: Acetates; Acetic Acid; Adult; Aged; Axilla; Breast Neoplasms; Chloroform; Ethanol; Fixatives; Formal | 1988 |
327 other studies available for formaldehyde and Breast Neoplasms
| Article | Year |
|---|---|
Choice of fixative is crucial to successful immunohistochemical detection of phosphoproteins in paraffin-embedded tumor tissues.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Colonic Neoplasms; Data Interpretation, Statistical; F | 2009 |
Identification of resting cells by dual-parameter flow cytometry of statin expression and DNA content.
Topics: 3T3 Cells; Animals; Antigens, Neoplasm; Apoptosis; Biomarkers; Breast Neoplasms; Bromodeoxyuridine; | 1995 |
Development and characterization of 1C6-203, a new monoclonal antibody specific to human thymidine phosphorylase.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Blotting, Western; Breast Neoplasms; Colorect | 2001 |
Simultaneous measurement of progesterone receptors and DNA indices by flow cytometry: characterization of an assay in breast cancer cell lines.
Topics: Antibodies, Monoclonal; Biomarkers, Tumor; Breast Neoplasms; Cell Line; DNA, Neoplasm; Female; Flow | 1989 |
Analytical Validation of a Novel 6-Gene Signature for Prediction of Distant Recurrence in Estrogen Receptor-Positive, HER2-Negative, Early-Stage Breast Cancer.
Topics: Biomarkers, Tumor; Breast; Breast Neoplasms; Female; Formaldehyde; Gene Expression Profiling; Humans | 2022 |
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; In Situ Hybridization; Membrane Proteins; Paraffin E | 2022 |
Indocyanine green fluorescence image processing techniques for breast cancer macroscopic demarcation.
Topics: Breast Neoplasms; Female; Fluorescence; Formaldehyde; Humans; Indocyanine Green; Margins of Excision | 2022 |
Results and lessons from dual extraction of DNA and RNA from formalin-fixed paraffin-embedded breast tumor tissues for a large Cancer epidemiologic study.
Topics: Breast Neoplasms; DNA; Endopeptidase K; Female; Formaldehyde; Humans; Paraffin Embedding; RNA; Tissu | 2022 |
Evaluation of EDB Fibronectin in Plasma, Patient-Derived Xenograft Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tumor Tissues Using Immunoaffinity LC-MS/MS.
Topics: Animals; Breast Neoplasms; Chromatography, Liquid; Disease Models, Animal; Female; Fibronectins; For | 2022 |
Detection of High-Risk Human Papillomavirus DNA in Invasive Ductal Carcinoma Specimens.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Alphapapillomavirus; Breast Neoplasms; Carcinoma, Ductal | 2022 |
Breast cancer or surrounding normal tissue? A successful discrimination by FTIR or Raman microspectroscopy.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Spectroscopy, Fourier Transform Infrared; Spectrum A | 2022 |
Quality Assessment of Proteins and RNA Following Storage in Archival Formalin-Fixed Paraffin-Embedded Human Breast Cancer Tissue Microarray Sections.
Topics: Breast Neoplasms; Cadherins; Female; Formaldehyde; Humans; Immunohistochemistry; Ki-67 Antigen; Para | 2023 |
A room-temperature formaldehyde sensor based on hematite for breast cancer diagnosis.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Oxygen; Temperature | 2023 |
A room-temperature formaldehyde sensor based on hematite for breast cancer diagnosis.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Oxygen; Temperature | 2023 |
A room-temperature formaldehyde sensor based on hematite for breast cancer diagnosis.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Oxygen; Temperature | 2023 |
A room-temperature formaldehyde sensor based on hematite for breast cancer diagnosis.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Oxygen; Temperature | 2023 |
Assessment of stained direct cytology smears of breast cancer for whole transcriptome and targeted messenger RNA sequencing.
Topics: Breast Neoplasms; Female; Formaldehyde; Gene Expression Profiling; Humans; Paraffin Embedding; RNA; | 2023 |
Evaluation of 95-Gene Classifier of Formalin-fixed Paraffin-embedded Tissues in ER-positive, HER2-negative, and Node-negative Breast Cancer.
Topics: Breast Neoplasms; Chemotherapy, Adjuvant; Female; Formaldehyde; Humans; Neoplasm Recurrence, Local; | 2023 |
In Situ Proximity Ligation Assay to Visualize Protein-Protein Interactions in Tumor Specimens.
Topics: Antibodies; Breast Neoplasms; Cell Nucleus; Cohort Studies; Female; Fluorescent Dyes; Formaldehyde; | 2023 |
Visualization of Small Intact Proteins in Breast Cancer FFPE Tissue.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Paraffin Embedding; Proteins; Proteomics; Spectromet | 2023 |
Bioinformatics and DNA-extraction strategies to reliably detect genetic variants from FFPE breast tissue samples.
Topics: Breast; Breast Neoplasms; DNA Mutational Analysis; DNA, Neoplasm; Female; Fixatives; Formaldehyde; G | 2019 |
Spatially Resolved Genetic Analysis of Tissue Sections Enabled by Microscale Flow Confinement Retrieval and Isotachophoretic Purification.
Topics: Breast Neoplasms; DNA, Neoplasm; Female; Formaldehyde; Genotype; Humans; MCF-7 Cells; Microscopy, Co | 2019 |
The impact of RNA extraction method on accurate RNA sequencing from formalin-fixed paraffin-embedded tissues.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Exome Sequencing; Female; Formaldehyde; Gene Expre | 2019 |
RNA-seq from archival FFPE breast cancer samples: molecular pathway fidelity and novel discovery.
Topics: Breast Neoplasms; Formaldehyde; Humans; Paraffin Embedding; Receptors, Estrogen; RNA-Seq; Signal Tra | 2019 |
Unlocking the transcriptomic potential of formalin-fixed paraffin embedded clinical tissues: comparison of gene expression profiling approaches.
Topics: Breast Neoplasms; Female; Fixatives; Formaldehyde; Gene Expression Profiling; Humans; Microarray Ana | 2020 |
Clinical Application of Multiple Reaction Monitoring-Mass Spectrometry to Human Epidermal Growth Factor Receptor 2 Measurements as a Potential Diagnostic Tool for Breast Cancer Therapy.
Topics: Adult; Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Humans; Mass Spectrometry; Middle | 2020 |
SAXS-CT: a nanostructure resolving microscopy for macroscopic biologic specimens.
Topics: Breast; Breast Neoplasms; Carcinoma; Collagen; Female; Formaldehyde; Freeze Drying; Humans; Image Pr | 2020 |
Quantification of Human Epidermal Growth Factor Receptor 2 by Immunopeptide Enrichment and Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded and Frozen Breast Cancer Tissues.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Humans; Mass Spectrometry; Paraffin Embed | 2021 |
Integrative analysis of copy number and gene expression in breast cancer using formalin-fixed paraffin-embedded core biopsy tissue: a feasibility study.
Topics: Adult; Aged; Breast Neoplasms; Feasibility Studies; Female; Formaldehyde; Gene Dosage; Gene Expressi | 2017 |
MALDI Imaging-Guided Microproteomic Analyses of Heterogeneous Breast Tumors-A Pilot Study.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cluster Analysis; Female; Formaldehyde; Humans; Laser C | 2018 |
Effects of Hydrochloric Acid and Formic Acid Decalcification on Breast Tumor Biomarkers and HER2 Fluorescence In Situ Hybridization.
Topics: Biomarkers, Tumor; Biopsy, Large-Core Needle; Breast Neoplasms; Female; Formaldehyde; Humans; Hydroc | 2019 |
Human epidermal growth factor receptor 2 amplification detection by droplet digital polymerase chain reaction in formalin-fixed paraffin-embedded breast and gastric cancer samples.
Topics: Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Gene Amplificati | 2017 |
Gene expression modules in primary breast cancers as risk factors for organotropic patterns of first metastatic spread: a case control study.
Topics: Aged; Bone Neoplasms; Breast Neoplasms; Case-Control Studies; Female; Formaldehyde; Gene Expression | 2017 |
Characterization of PD-L1 Immunohistochemical Expression in Cell Blocks With Different Specimen Fixation and Processing Methods.
Topics: B7-H1 Antigen; Biomarkers, Tumor; Breast Neoplasms; Female; Fixatives; Formaldehyde; Gene Expression | 2019 |
Formalin-fixed paraffin-embedded sample conditions for deep next generation sequencing.
Topics: Biopsy; Breast Neoplasms; Colorectal Neoplasms; DNA; Female; Formaldehyde; High-Throughput Nucleotid | 2017 |
Profiling differential microRNA expression between in situ, infiltrative and lympho-vascular space invasive breast cancer: a pilot study.
Topics: Adult; Aged; Axilla; Blood Vessels; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraduc | 2018 |
MALDI Imaging Combined with Laser Microdissection-Based Microproteomics for Protein Identification: Application to Intratumor Heterogeneity Studies.
Topics: Animals; Breast; Breast Neoplasms; Female; Formaldehyde; Humans; Laser Capture Microdissection; Para | 2018 |
[Volume of 4% neutral buffered formaldehyde affects the results of
Topics: Breast Neoplasms; Buffers; Formaldehyde; Humans; In Situ Hybridization, Fluorescence; Receptor, ErbB | 2017 |
Next-Generation Sequencing Analysis of Laser-Microdissected Formalin-Fixed and Paraffin-Embedded (FFPE) Tissue Specimens.
Topics: Adenomyoepithelioma; Breast Neoplasms; DNA, Neoplasm; Female; Formaldehyde; High-Throughput Nucleoti | 2018 |
Feasibility of analyzing DNA copy number variation in breast cancer tumor specimens from 1950 to 2010: how old is too old?
Topics: Breast Neoplasms; DNA; DNA Copy Number Variations; Female; Formaldehyde; Humans; Paraffin Embedding; | 2018 |
Shallow whole genome sequencing for robust copy number profiling of formalin-fixed paraffin-embedded breast cancers.
Topics: Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; DNA; DNA Copy Number Variations; Female; | 2018 |
A rapid triage protocol to optimize cold ischemic time for breast resection specimens.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breast; Breast Neoplasms; Child; Cold Ischemia; Female; | 2018 |
Detection of HER2 amplification in formalin-fixed paraffin-embedded breast carcinoma tissue with digital PCR using two TFF3 sequences as internal reference.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Gene Amplification; Humans; In Situ Hybri | 2018 |
Feasibility of developing reliable gene expression modules from FFPE derived RNA profiled on Affymetrix arrays.
Topics: Breast Neoplasms; Female; Formaldehyde; Gene Expression Regulation, Neoplastic; Gene Regulatory Netw | 2018 |
Progression-specific genes identified in microdissected formalin-fixed and paraffin-embedded tissue containing matched ductal carcinoma in situ and invasive ductal breast cancers.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Disease Progre | 2018 |
Robustness of biomarker determination in breast cancer by RT-qPCR: impact of tumor cell content, DCIS and non-neoplastic breast tissue.
Topics: Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Carcinoma, Intraductal, Noninfiltrating; Estrogen Re | 2018 |
Improved Multiplex Immunohistochemistry for Immune Microenvironment Evaluation of Mouse Formalin-Fixed, Paraffin-Embedded Tissues.
Topics: Animals; Antigens; Antigens, Differentiation; Breast Neoplasms; Buffers; Cell Line, Tumor; Cell Sepa | 2019 |
Comparison of protein expression between formalin-fixed core-cut biopsies and surgical excision specimens using a novel multiplex approach.
Topics: AMP-Activated Protein Kinase Kinases; Biomarkers, Tumor; Biopsy, Large-Core Needle; Breast Neoplasms | 2019 |
Frequency of Epstein–Barr Virus DNA in Formalin-Fixed Paraffin-Embedded Tissue of Patients with Ductal Breast\
Carcinoma
Topics: Adult; Breast Neoplasms; Carcinoma, Ductal, Breast; Case-Control Studies; DNA, Viral; Epstein-Barr V | 2019 |
Three-dimensional imaging and quantitative analysis in CLARITY processed breast cancer tissues.
Topics: Animals; Biomarkers, Tumor; Biopsy; Biopsy, Large-Core Needle; Breast; Breast Neoplasms; Coloring Ag | 2019 |
Targeted capture-based NGS is superior to multiplex PCR-based NGS for hereditary BRCA1 and BRCA2 gene analysis in FFPE tumor samples.
Topics: BRCA1 Protein; BRCA2 Protein; Breast Neoplasms; DNA Copy Number Variations; Female; Formaldehyde; Ge | 2019 |
A model for the impact of FFPE section thickness on gene copy number measurement by FISH.
Topics: Breast Neoplasms; Cell Line, Tumor; False Negative Reactions; Female; Formaldehyde; Gene Amplificati | 2019 |
Enhancing the evanescent field in TiO
Topics: Biomarkers, Tumor; Biosensing Techniques; Breast Neoplasms; Exhalation; Female; Formaldehyde; Gold; | 2019 |
Next-generation RNA sequencing of FFPE subsections reveals highly conserved stromal reprogramming between canine and human mammary carcinoma.
Topics: Animals; Breast Neoplasms; Dogs; Female; Formaldehyde; Gene Expression Regulation, Neoplastic; High- | 2019 |
Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats.
Topics: Animals; Behavior, Animal; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Disease Models, Anima | 2013 |
Multiplex epitope detection: a new method overcomes limitations of antibody arrays.
Topics: Antibodies; Biomarkers, Tumor; Breast Neoplasms; Epitopes; Female; Fixatives; Formaldehyde; Humans; | 2013 |
Next-generation sequencing and microarray-based interrogation of microRNAs from formalin-fixed, paraffin-embedded tissue: preliminary assessment of cross-platform concordance.
Topics: Breast Neoplasms; Cryopreservation; DNA, Complementary; Female; Formaldehyde; Gene Expression Profil | 2013 |
Evaluating the repair of DNA derived from formalin-fixed paraffin-embedded tissues prior to genomic profiling by SNP-CGH analysis.
Topics: Breast Neoplasms; Comparative Genomic Hybridization; DNA; DNA Copy Number Variations; Female; Fixati | 2013 |
[Simplified, low-cost gene expression profiling for the prediction of outcome in breast cancer based on routine histologic specimens].
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Computer Simulation; Disease-Free Survival; Female | 2013 |
Multiple protein analysis of formalin-fixed and paraffin-embedded tissue samples with reverse phase protein arrays.
Topics: Blotting, Western; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Female; Formaldehyde; Humans; I | 2013 |
Application of selected reaction monitoring for multiplex quantification of clinically validated biomarkers in formalin-fixed, paraffin-embedded tumor tissue.
Topics: Biomarkers, Tumor; Breast Neoplasms; Enzyme-Linked Immunosorbent Assay; ErbB Receptors; Female; Form | 2013 |
Breast cancer and melanoma cell line identification by FTIR imaging after formalin-fixation and paraffin-embedding.
Topics: Barium Compounds; Breast Neoplasms; Female; Fluorides; Formaldehyde; Humans; Melanoma; Paraffin Embe | 2013 |
Eradication of breast cancer with bone metastasis by autologous formalin-fixed tumor vaccine (AFTV) combined with palliative radiation therapy and adjuvant chemotherapy: a case report.
Topics: Anastrozole; Androstadienes; Antineoplastic Combined Chemotherapy Protocols; Autoantigens; Bone Neop | 2013 |
Lack of detection of the mouse mammary tumor-like virus (MMTV) Env gene in Iranian women breast cancer using real time PCR.
Topics: Breast Neoplasms; Carcinoma, Ductal; DNA, Viral; Female; Formaldehyde; Gene Products, env; Humans; I | 2013 |
Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue.
Topics: 3,3'-Diaminobenzidine; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Colonic Neoplasms; Fem | 2013 |
Optimal reference genes for normalization of qRT-PCR data from archival formalin-fixed, paraffin-embedded breast tumors controlling for tumor cell content and decay of mRNA.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Paraffin; Pathology, Molecular; Real-Time Polymerase | 2013 |
Protein expression profiling of formalin-fixed paraffin-embedded tissue using recombinant antibody microarrays.
Topics: Breast Neoplasms; Escherichia coli; Female; Fixatives; Formaldehyde; Gene Expression; Gene Expressio | 2013 |
Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cytodiagnosis; Female; Formaldehyde; Gene Expression Profiling; | 2013 |
Determination of phosphorylated proteins in tissue specimens requires high-quality samples collected under stringent conditions.
Topics: Biomarkers, Tumor; Biopsy; Blotting, Western; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Extr | 2014 |
Imaging cycler microscopy.
Topics: Biomarkers, Tumor; Breast Neoplasms; Colonic Neoplasms; Female; Formaldehyde; Humans; Microscopy, Fl | 2014 |
Separate quality-control measures are necessary for estimation of RNA and methylated DNA from formalin-fixed, paraffin-embedded specimens by quantitative PCR.
Topics: Breast Neoplasms; DNA; DNA Methylation; Female; Formaldehyde; Humans; Paraffin Embedding; Quality Co | 2014 |
Importance of formalin fixing conditions for HER2 testing in gastric cancer: immunohistochemical staining and fluorescence in situ hybridization.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Female; Formaldehyde; Humans; Immuno | 2014 |
Extraction of tamoxifen and its metabolites from formalin-fixed, paraffin-embedded tissues: an innovative quantitation method using liquid chromatography and tandem mass spectrometry.
Topics: Breast Neoplasms; Chromatography, Liquid; Female; Formaldehyde; Humans; Neoplasm Recurrence, Local; | 2014 |
72-gene classifier for predicting prognosis of estrogen receptor-positive and node-negative breast cancer patients using formalin-fixed, paraffin-embedded tumor tissues.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Disease-Free Survival; Female; | 2014 |
Imaging mass spectrometry to discriminate breast from pancreatic cancer metastasis in formalin-fixed paraffin-embedded tissues.
Topics: Biomarkers, Tumor; Breast Neoplasms; Diagnosis, Differential; Female; Formaldehyde; Gene Expression | 2014 |
Accurate data processing improves the reliability of Affymetrix gene expression profiles from FFPE samples.
Topics: Algorithms; Breast Neoplasms; Databases, Factual; Female; Formaldehyde; Gene Expression; Gene Expres | 2014 |
Assessment of the 2-d gel-based proteomics application of clinically archived formalin-fixed paraffin embedded tissues.
Topics: Biomarkers, Tumor; Breast; Breast Neoplasms; Cryopreservation; Electrophoresis, Gel, Two-Dimensional | 2014 |
Reply to Schubert et al.: Regarding critique of highly multiplexed technologies.
Topics: Biomarkers, Tumor; Breast Neoplasms; Colonic Neoplasms; Female; Formaldehyde; Humans; Microscopy, Fl | 2014 |
Expression level of miR-93 in formalin-fixed paraffin-embedded tissues of breast cancer patients.
Topics: Adult; Base Sequence; Biomarkers, Tumor; Breast Neoplasms; Case-Control Studies; DNA Primers; Female | 2014 |
Brief formalin fixation and rapid tissue processing do not affect the sensitivity of ER immunohistochemistry of breast core biopsies.
Topics: Biopsy, Needle; Breast Neoplasms; Carcinoma, Ductal, Breast; Estrogen Receptor alpha; Female; Formal | 2014 |
Analytical validation of the PAM50-based Prosigna Breast Cancer Prognostic Gene Signature Assay and nCounter Analysis System using formalin-fixed paraffin-embedded breast tumor specimens.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Gene Expression Regulation, Neoplastic; H | 2014 |
The use of mouse models of breast cancer and quantitative image analysis to evaluate hormone receptor antigenicity after microwave-assisted formalin fixation.
Topics: Algorithms; Animals; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; ErbB Receptors; Fem | 2014 |
Over-expression of miR-98 in FFPE tissues might serve as a valuable source for biomarker discovery in breast cancer patients.
Topics: Adult; Aged; Area Under Curve; Biomarkers; Breast Neoplasms; Female; Formaldehyde; Humans; MicroRNAs | 2014 |
Brief fixation does not affect assessment of hormone receptor expression in invasive breast carcinoma biopsies: paving the road for same-day tissue diagnostics.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Biopsy, Large-Core Needle; Breast Neoplasms; Carc | 2014 |
Fusion transcript discovery in formalin-fixed paraffin-embedded human breast cancer tissues reveals a link to tumor progression.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Gene Expression Profiling; High-Throughpu | 2014 |
Comparison of the results of PCR analysis of gene expression in breast cancer tissue specimens stabilized in formalin and RNAlater.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Fixatives; Formaldehyde; Gene Expression; Gene | 2014 |
Overexpression of the EMT driver brachyury in breast carcinomas: association with poor prognosis.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Cell Line, Tumor; Epithelial-Mesenchymal Transitio | 2014 |
Immunohistochemical Ki-67/KL1 double stains increase accuracy of Ki-67 indices in breast cancer and simplify automated image analysis.
Topics: Automation; Breast Neoplasms; Endopeptidases; Female; Formaldehyde; Humans; Image Processing, Comput | 2014 |
MicroRNA expression signatures for the prediction of BRCA1/2 mutation-associated hereditary breast cancer in paraffin-embedded formalin-fixed breast tumors.
Topics: Breast Neoplasms; Female; Formaldehyde; Genes, BRCA1; Genes, BRCA2; Humans; Logistic Models; MicroRN | 2015 |
Intratumoral DNA content heterogeneity in breast carcinomas demonstrated by core punch tissue sampling and flow cytometry.
Topics: Adult; Aged; Aged, 80 and over; Biopsy, Large-Core Needle; Breast Neoplasms; Carcinoma; Case-Control | 2014 |
Identifying a highly-aggressive DCIS subgroup by studying intra-individual DCIS heterogeneity among invasive breast cancer patients.
Topics: Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrat | 2014 |
Delay to formalin fixation effect on HER2 test in breast cancer by dual-color silver-enhanced in situ hybridization (Dual-ISH).
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; In Situ Hybridization; Receptor, ErbB-2; Silver Stai | 2014 |
Association between mir-24 and mir-378 in formalin-fixed paraffin-embedded tissues of breast cancer.
Topics: Adult; Area Under Curve; Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Humans; MicroRNA | 2014 |
Paclitaxel-induced hyposensitivity to nociceptive chemical stimulation in mice can be prevented by treatment with minocycline.
Topics: Animals; Breast Neoplasms; Female; Formaldehyde; Humans; Hyperalgesia; Mice; Minocycline; Nociceptio | 2014 |
Evaluation of BrightGen HR RT-qDx assay to detect nuclear receptors mRNA overexpression in FFPE breast cancer tissue samples for selection of tamoxifen therapy.
Topics: Area Under Curve; Biomarkers, Tumor; Breast Neoplasms; Estrogen Antagonists; Female; Fixatives; Form | 2014 |
Quantitative RT-PCR assay of HER2 mRNA expression in formalin-fixed and paraffin-embedded breast cancer tissues.
Topics: Biomarkers, Tumor; Biopsy; Breast Neoplasms; Cell Line, Tumor; Female; Fixatives; Formaldehyde; Hosp | 2014 |
Preanalytical variables and phosphoepitope expression in FFPE tissue: quantitative epitope assessment after variable cold ischemic time.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cold Ischemia; Epitopes; Female; Fluorescent Antibody Technique | 2015 |
Application of tissue mesodissection to molecular cancer diagnostics.
Topics: Automation, Laboratory; Biopsy; Breast Neoplasms; DNA Mutational Analysis; Equipment Design; Female; | 2015 |
Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for germline pharmacogenetic studies.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Biomarkers, Tumor; Breast Neoplasms; Cytochrome P-450 | 2014 |
Microscopic diffusion properties of fixed breast tissue: Preliminary findings.
Topics: Adult; Breast; Breast Neoplasms; Diffusion; Diffusion Magnetic Resonance Imaging; Female; Fixatives; | 2015 |
Standardized processing of native tissue in breast pathology.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Sentinel Lymph Node Biopsy; Specimen Handling; Tissu | 2015 |
Short formalin fixation and rapid microwave processing do not affect HER2 testing.
Topics: Adult; Aged; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma, Ductal, Breast; Cell Line, Tumor; | 2015 |
Loss of heterozygosity at the CYP2D6 locus in breast cancer: implications for tamoxifen pharmacogenetic studies.
Topics: Adult; Aged; Antineoplastic Agents, Hormonal; Breast Neoplasms; Cytochrome P-450 CYP2D6; Drug Admini | 2015 |
Evaluation of HER2 Gene Status in Breast Cancer Samples with Indeterminate Fluorescence in Situ Hybridization by Quantitative Real-Time PCR.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Gene Amplification; Gene Expression Regul | 2015 |
Diagnosis of Basal-Like Breast Cancer Using a FOXC1-Based Assay.
Topics: Adult; Aged; Area Under Curve; Biomarkers, Tumor; Brain Neoplasms; Breast Neoplasms; Carcinoma, Basa | 2015 |
Quantification of HER2 by Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded (FFPE) Breast Cancer Tissues.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; In Situ Hybridization, Fluorescence; Mass Spectromet | 2015 |
Genotyping concordance in DNA extracted from formalin-fixed paraffin embedded (FFPE) breast tumor and whole blood for pharmacogenetic analyses.
Topics: Breast; Breast Neoplasms; DNA; Female; Formaldehyde; Genotyping Techniques; Humans; Paraffin Embeddi | 2015 |
Comparative Sensitivities and Specificities of Antibodies to Breast Markers GCDFP-15, Mammaglobin A, and Different Clones of Antibodies to GATA-3: A Study of 338 Tumors Using Whole Sections.
Topics: Antibody Specificity; Biomarkers, Tumor; Breast Neoplasms; Carrier Proteins; Female; Formaldehyde; G | 2016 |
Quantitative real-time polymerase chain reaction is an alternative method for the detection of HER-2 amplification in formalin-fixed paraffin-embedded breast cancer samples.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Fixatives; Formaldehyde; Gene Amplification; Gene Expre | 2015 |
Droplet digital polymerase chain reaction detection of HER2 amplification in formalin fixed paraffin embedded breast and gastric carcinoma samples.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Cell Line, Tumor; Female; Fixatives; Formaldehyde; | 2016 |
Pyrosequencing Analysis for Breast Cancer DNA Methylome.
Topics: Breast Neoplasms; CpG Islands; DNA; DNA Methylation; DNA Primers; Eosine Yellowish-(YS); Formaldehyd | 2016 |
Methods for Studying MicroRNA Expression and Their Targets in Formalin-Fixed, Paraffin-Embedded (FFPE) Breast Cancer Tissues.
Topics: Breast Neoplasms; Cloning, Molecular; DNA, Complementary; Formaldehyde; Gene Expression Profiling; H | 2016 |
Proteomic Analysis of Stage-II Breast Cancer from Formalin-Fixed Paraffin-Embedded Tissues.
Topics: Biomarkers, Tumor; Breast Neoplasms; Electrophoresis, Gel, Two-Dimensional; Female; Formaldehyde; Ge | 2016 |
Expression of proliferation genes in formalin-fixed paraffin-embedded (FFPE) tissue from breast carcinomas. Feasibility and relevance for a routine histopathology laboratory.
Topics: Aurora Kinase A; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Cycle Proteins | 2017 |
Protocol for HER2 FISH determination on PAXgene-fixed and paraffin-embedded tissue in breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Clinical Protocols; Female; Fixatives; Formaldehyd | 2016 |
Visualization of Grossly Undetectable Breast Tumors by Refixation in Lymph Node Revealing Solution.
Topics: Acetic Acid; Breast Carcinoma In Situ; Breast Neoplasms; Carcinoma, Ductal, Breast; Ethanol; Ether; | 2016 |
BRCA1/FANCD2/BRG1-Driven DNA Repair Stabilizes the Differentiation State of Human Mammary Epithelial Cells.
Topics: Acetaldehyde; BRCA1 Protein; Breast Neoplasms; Cell Differentiation; Cell Line; Cell Transformation, | 2016 |
Simultaneous detection of BRCA mutations and large genomic rearrangements in germline DNA and FFPE tumor samples.
Topics: BRCA1 Protein; BRCA2 Protein; Breast Neoplasms; Computational Biology; DNA; DNA Mutational Analysis; | 2016 |
Reliable gene expression profiling of formalin-fixed paraffin-embedded breast cancer tissue (FFPE) using cDNA-mediated annealing, extension, selection, and ligation whole-genome (DASL WG) assay.
Topics: Breast Neoplasms; DNA, Complementary; Formaldehyde; Gene Expression Profiling; Genomics; Paraffin Em | 2016 |
Clinical Usefulness of a One-Tube Nested Reverse Transcription Quantitative Polymerase Chain Reaction Assay for Evaluating Human Epidermal Growth Factor Receptor 2 mRNA Overexpression in Formalin-Fixed and Paraffin-Embedded Breast Cancer Tissue Samples.
Topics: Biomarkers, Tumor; Breast; Breast Neoplasms; Cell Line, Tumor; Female; Formaldehyde; Humans; Immunoh | 2017 |
Comparison of the types of candidate reference samples for quality control of human epidermal growth factor receptor 2 status detection.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Electrophoresis, Agar Gel; Female; Fixatives; Formalde | 2016 |
The role of miRNAs in drug resistance and prognosis of breast cancer formalin-fixed paraffin-embedded tissues.
Topics: Biomarkers, Tumor; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Formaldehyde; Gene Expressio | 2016 |
Assessment of Significance of Novel Proteins in Breast Cancer Using Tissue Microarray Technology.
Topics: Antibodies; Breast Neoplasms; Female; Formaldehyde; Humans; Immunohistochemistry; Paraffin Embedding | 2017 |
Copy number analysis by low coverage whole genome sequencing using ultra low-input DNA from formalin-fixed paraffin embedded tumor tissue.
Topics: Breast Neoplasms; Carcinoma, Merkel Cell; Cell Line, Tumor; Cohort Studies; Cost-Benefit Analysis; D | 2016 |
Denaturing fixatives are compatible with the NanoString nCounter
Topics: Acetic Acid; Biotechnology; Breast Neoplasms; Female; Fixatives; Formaldehyde; Humans; Nucleic Acid | 2017 |
A Super-SILAC Strategy for the Accurate and Multiplexed Profiling of Histone Posttranslational Modifications.
Topics: Breast Neoplasms; Cell Line, Tumor; Chromatography, High Pressure Liquid; Female; Formaldehyde; Hist | 2017 |
Expression Quantitative Trait loci (QTL) in tumor adjacent normal breast tissue and breast tumor tissue.
Topics: Aged; Aged, 80 and over; Breast; Breast Neoplasms; Female; Formaldehyde; Gene Expression Profiling; | 2017 |
Whole-genome single-cell copy number profiling from formalin-fixed paraffin-embedded samples.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Cell Nucleus; | 2017 |
Optimization of the method of RNA isolation from paraffin blocks to assess gene expression in breast cancer.
Topics: Adenocarcinoma; Breast Neoplasms; Female; Fixatives; Formaldehyde; Gene Expression Profiling; Gene E | 2008 |
Protein unlocking procedures of formalin-fixed paraffin-embedded tissues: application to MALDI-TOF imaging MS investigations.
Topics: Breast Neoplasms; Formaldehyde; Humans; Neoplasm Proteins; Paraffin Embedding; Serum Albumin, Bovine | 2008 |
[Predictive and prognostic markers of breast cancer. Molecular biological analysis of fixed tumor tissue].
Topics: Algorithms; Biomarkers, Tumor; Breast; Breast Neoplasms; DNA, Neoplasm; Equipment Design; Female; Fi | 2008 |
Recommendations for collection and handling of specimens from group breast cancer clinical trials.
Topics: Breast Neoplasms; Clinical Trials as Topic; Ethics, Medical; Formaldehyde; Guidelines as Topic; Huma | 2008 |
Reliable microRNA profiling in routinely processed formalin-fixed paraffin-embedded breast cancer specimens using fluorescence labelled bead technology.
Topics: Breast Neoplasms; Fluorescent Dyes; Formaldehyde; Frozen Sections; Gene Expression Profiling; Gene E | 2008 |
Analysis of DNA methylation of multiple genes in microdissected cells from formalin-fixed and paraffin-embedded tissues.
Topics: Adipose Tissue; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraduct | 2009 |
A single-tube quantitative assay for mRNA levels of hormonal and growth factor receptors in breast cancer specimens.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Molecular Diagnostic Techniques; Paraffin Embedding; | 2009 |
Analysis of breast cancer by small angle X-ray scattering (SAXS).
Topics: Adult; Aged; Breast; Breast Neoplasms; Discriminant Analysis; Formaldehyde; Humans; Middle Aged; Rep | 2009 |
RNA extraction from archival formalin-fixed paraffin-embedded tissue: a comparison of manual, semiautomated, and fully automated purification methods.
Topics: Automation; Biomarkers, Tumor; Breast Neoplasms; Formaldehyde; Gene Expression; Genetic Techniques; | 2009 |
Delay to formalin fixation effect on breast biomarkers.
Topics: Adult; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Fixatives; Formaldehy | 2009 |
Improvement of the clinical applicability of the Genomic Grade Index through a qRT-PCR test performed on frozen and formalin-fixed paraffin-embedded tissues.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Female; Formaldehyde; Frozen Sections; Genes, Neop | 2009 |
A high-sensitivity, medium-density, and target amplification-free planar waveguide microarray system for gene expression analysis of formalin-fixed and paraffin-embedded tissue.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Oligonucleotide Array Sequence Analysis; Paraffin Em | 2009 |
Quantitative infrared spectroscopy of formalin-fixed, paraffin-embedded tissue specimens: paraffin wax removal with organic solvents.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Line; Evaluation Studies as Topic; Female; Formaldehyde; H | 2009 |
Oligonucleotide probe array for p53 gene alteration analysis in DNA from formalin-fixed paraffin-embedded breast cancer tissues.
Topics: Breast Neoplasms; DNA Mutational Analysis; DNA, Neoplasm; Female; Formaldehyde; Humans; Mutation; Ol | 2009 |
Quantitative DNA methylation analysis of laser capture microdissected formalin-fixed and paraffin-embedded tissues.
Topics: Breast Neoplasms; Cell Line, Tumor; DNA Methylation; DNA Restriction Enzymes; DNA, Neoplasm; Female; | 2010 |
Protein and gene expression of estrogen receptor alpha and nuclear morphology of two breast cancer cell lines after different fixation methods.
Topics: Breast Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Nucleus; Estrogen Receptor alpha; | 2010 |
Multiplexed tandem polymerase chain reaction identifies strong expression of oestrogen receptor and Her-2 from single, formalin-fixed, paraffin-embedded breast cancer sections.
Topics: Biomarkers, Tumor; Breast Neoplasms; DNA Fingerprinting; DNA, Neoplasm; Female; Formaldehyde; Health | 2010 |
[Comparison of two HER-2 FISH kits on formalin-fixed paraffin-embedded tissues: signal detection and simple procedure].
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Humans; In Situ Hybridization, Fluorescen | 2010 |
Protocol for PTEN expression by immunohistochemistry in formalin-fixed paraffin-embedded human breast carcinoma.
Topics: Automation; Blotting, Western; Breast Neoplasms; Carcinoma; Cell Line, Tumor; Female; Formaldehyde; | 2010 |
Fixation time does not affect the expression of estrogen receptor.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Count; Female; Fixatives; Formaldehyde; Humans; Immunohist | 2010 |
Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain.
Topics: Acids; Animals; Bone Neoplasms; Breast Neoplasms; CHO Cells; Cricetinae; Cricetulus; Female; Formald | 2010 |
Feasibility of using tissue microarray cores of paraffin-embedded breast cancer tissue for measurement of gene expression: a proof-of-concept study.
Topics: Breast Neoplasms; Feasibility Studies; Female; Fixatives; Formaldehyde; Gene Expression; Gene Expres | 2010 |
Comparison of gene expression profiling by reverse transcription quantitative PCR between fresh frozen and formalin-fixed, paraffin-embedded breast cancer tissues.
Topics: Biological Assay; Breast Neoplasms; Female; Fixatives; Formaldehyde; Frozen Sections; Gene Expressio | 2010 |
Gene expression profiling of formalin-fixed, paraffin-embedded familial breast tumours using the whole genome-DASL assay.
Topics: Ataxia Telangiectasia Mutated Proteins; Breast Neoplasms; Cell Cycle Proteins; Cryopreservation; DNA | 2010 |
[Analysis of signalling pathways in formalin-fixed breast cancer tissues].
Topics: Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Female; Formaldehyde; Huma | 2010 |
Quantitation of p95HER2 in paraffin sections by using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antibody Specificity; Antineoplastic Agen | 2010 |
Comparative validation of the SP6 antibody to Ki67 in breast cancer.
Topics: Antibodies, Monoclonal; Antineoplastic Agents; Aromatase Inhibitors; Biomarkers, Tumor; Breast Neopl | 2010 |
[HER2 ASCO guidelines. The answer to everything?].
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Biomarkers, Tumor; | 2010 |
Gene expression array testing of FFPE archival breast tumor samples: an optimized protocol for WG-DASL sample preparation.
Topics: Breast; Breast Neoplasms; Cluster Analysis; Cohort Studies; Estrogen Receptor alpha; Female; Formald | 2011 |
Fixation time does not affect expression of HER2/neu: a pilot study.
Topics: Animals; Antibodies, Monoclonal; Breast Neoplasms; Female; Fixatives; Formaldehyde; Humans; Immunohi | 2010 |
Extreme loss of immunoreactive p-Akt and p-Erk1/2 during routine fixation of primary breast cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Humans; Ki-67 Antigen; Mitogen-Activated | 2010 |
Immunohistochemistry of breast tumor markers on archived bouin-fixed paraffin-embedded tissues.
Topics: Acetic Acid; Biological Specimen Banks; Biomarkers, Tumor; Breast Neoplasms; Female; Fixatives; Form | 2011 |
Automated extraction of DNA and RNA from a single formalin-fixed paraffin-embedded tissue section for analysis of both single-nucleotide polymorphisms and mRNA expression.
Topics: Automation, Laboratory; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; DNA; Female; Fixative | 2010 |
Effect of delayed formalin fixation on estrogen and progesterone receptors in breast cancer: a study of three different clones.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Humans; Immunohistochemistry; Receptor, E | 2010 |
Nucleic acid sequence-based amplification in formalin-fixed and paraffin-embedded breast-cancer tissues.
Topics: Breast Neoplasms; Feasibility Studies; Female; Formaldehyde; Genes, erbB-2; Genes, Neoplasm; Humans; | 2010 |
Analyses and interpretation of whole-genome gene expression from formalin-fixed paraffin-embedded tissue: an illustration with breast cancer tissues.
Topics: Analysis of Variance; Breast Neoplasms; Cluster Analysis; Databases, Genetic; Down-Regulation; Femal | 2010 |
Differential proteomic analysis of late-stage and recurrent breast cancer from formalin-fixed paraffin-embedded tissues.
Topics: Adult; Aged; Animals; Biomarkers, Tumor; Breast Neoplasms; Chromatography, Liquid; Disease Progressi | 2011 |
A multiplex endpoint RT-PCR assay for quality assessment of RNA extracted from formalin-fixed paraffin-embedded tissues.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Paraffin Embedding; Reverse Transcriptase Polymerase | 2010 |
Quantitative determination of estrogen receptor, progesterone receptor, and HER2 mRNA in formalin-fixed paraffin-embedded tissue--a new option for predictive biomarker assessment in breast cancer.
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Humans; Paraffin Embedding; Receptor, Erb | 2011 |
Genome-wide gene expression profiling of formalin-fixed paraffin-embedded breast cancer core biopsies using microarrays.
Topics: Biopsy, Needle; Breast Neoplasms; Cluster Analysis; Estrogen Receptor alpha; Feasibility Studies; Fo | 2011 |
Gene expression profiles from formalin fixed paraffin embedded breast cancer tissue are largely comparable to fresh frozen matched tissue.
Topics: Breast Neoplasms; Cryopreservation; DNA, Complementary; Female; Formaldehyde; Gene Expression Profil | 2011 |
Fixation time does not affect expression of HER2/neu.
Topics: Breast Neoplasms; Female; Fixatives; Formaldehyde; Humans; Immunohistochemistry; Pilot Projects; Rec | 2011 |
Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cluster Analysis; ErbB Receptors; Female; Formaldehyde; Gene Ex | 2012 |
Clinical relevance of DNA microarray analyses using archival formalin-fixed paraffin-embedded breast cancer specimens.
Topics: Adult; Aged; Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Gene Expression Profiling; G | 2011 |
Proposals for uniform collection of biospecimens from neoadjuvant breast cancer clinical trials: timing and specimen types.
Topics: Biopsy; Breast Neoplasms; Clinical Trials as Topic; Female; Fixatives; Formaldehyde; Humans; Molecul | 2011 |
Quantitative determination of insulin-like growth factor 1 receptor mRNA in formalin-fixed paraffin-embedded tissues of invasive breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Cryopreservation; Female; Forma | 2012 |
Evaluation and validation of a pretreatment method for automated genomic DNA and RNA extraction from clinical formalin-fixed paraffin-embedded samples using the MagNA Pure Compact System.
Topics: Automation; Breast Neoplasms; DNA, Neoplasm; Female; Formaldehyde; Humans; Nucleic Acid Amplificatio | 2011 |
Is breast specimen shrinkage really a problem in breast-conserving surgery?
Topics: Adult; Aged; Aged, 80 and over; Biopsy; Breast Neoplasms; Female; Fixatives; Formaldehyde; Humans; M | 2012 |
Histological assessment of PAXgene tissue fixation and stabilization reagents.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Immunohistochemistry; In Situ Hybridization; Indicat | 2011 |
Establishment of a standardized gene-expression analysis system using formalin-fixed, paraffin-embedded, breast cancer specimens.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Gene Expr | 2013 |
Biological and prognostic associations of miR-205 and let-7b in breast cancer revealed by in situ hybridization analysis of micro-RNA expression in arrays of archival tumour tissue.
Topics: Biomarkers, Tumor; Biopsy; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Chi-Squa | 2012 |
Clinical relevance of Ki67 gene expression analysis using formalin-fixed paraffin-embedded breast cancer specimens.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Gene Expr | 2013 |
Absence of evidence for epidermal growth factor receptor and human homolog of the Kirsten rat sarcoma-2 virus oncogene mutations in breast cancer.
Topics: Adult; Aged; Breast Neoplasms; China; DNA Mutational Analysis; ErbB Receptors; Female; Formaldehyde; | 2012 |
Identification of high-confidence somatic mutations in whole genome sequence of formalin-fixed breast cancer specimens.
Topics: Adult; Artifacts; Breast Neoplasms; DNA Damage; DNA Mutational Analysis; Female; Fixatives; Formalde | 2012 |
Delay to formalin fixation alters morphology and immunohistochemistry for breast carcinoma.
Topics: Biomarkers; Breast Neoplasms; Female; Formaldehyde; Humans; Immunohistochemistry; Neoplasm Invasiven | 2012 |
The effect of 96-hour formalin fixation on the immunohistochemical evaluation of estrogen receptor, progesterone receptor, and HER2 expression in invasive breast carcinoma.
Topics: Biomarkers, Tumor; Breast Neoplasms; Carcinoma; Estrogen Receptor alpha; Female; Fixatives; Formalde | 2012 |
Establishment of a monoclonal anti-pan HLA class I antibody suitable for immunostaining of formalin-fixed tissue: unusually high frequency of down-regulation in breast cancer tissues.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; beta 2-Microglobulin; Biomarkers, Tumor; Breast Neoplasm | 2012 |
Precision of multiple reaction monitoring mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue.
Topics: Amino Acid Sequence; Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Chromatography, | 2012 |
Comparison of breast carcinoma prognostic/predictive biomarkers on cell blocks obtained by various methods: Cellient, formalin and thrombin.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Biopsy, Fine-Needle; Breast Neoplasms; Cytodiagno | 2012 |
Immunohistochemical detection of estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 in formalin-fixed breast carcinoma cell block preparations: correlation of results to corresponding tissue block (needle core and excisi
Topics: Adenocarcinoma; Biomarkers, Tumor; Biopsy, Needle; Breast Neoplasms; Female; Fixatives; Formaldehyde | 2013 |
A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections.
Topics: Automation, Laboratory; Biomarkers, Tumor; Breast Neoplasms; Centromere; Chromosomes, Human, Pair 17 | 2012 |
Lectin array-based strategies for identifying metastasis-associated changes in glycosylation.
Topics: Breast Neoplasms; Formaldehyde; Glycosylation; Humans; Lectins; Neoplasm Metastasis; Paraffin Embedd | 2012 |
ER, PR, and Her2 immunocytochemistry on cell-transferred cytologic smears of primary and metastatic breast carcinomas: a comparison study with formalin-fixed cell blocks and surgical biopsies.
Topics: Adenocarcinoma; Biomarkers, Tumor; Biopsy, Fine-Needle; Breast Neoplasms; Cytological Techniques; Fe | 2013 |
Whole transcriptome RNA-Seq analysis of breast cancer recurrence risk using formalin-fixed paraffin-embedded tumor tissue.
Topics: Base Sequence; Biomarkers, Tumor; Breast Neoplasms; DNA, Intergenic; Female; Formaldehyde; Gene Expr | 2012 |
Development and comparative assessment of Raman spectroscopic classification algorithms for lesion discrimination in stereotactic breast biopsies with microcalcifications.
Topics: Adult; Aged; Algorithms; Biopsy, Large-Core Needle; Breast; Breast Neoplasms; Calcinosis; Female; Fo | 2013 |
The non-crosslinking fixative RCL2®-CS100 is compatible with both pathology diagnosis and molecular analyses.
Topics: Breast Neoplasms; Colorectal Neoplasms; Female; Fixatives; Formaldehyde; Histocytochemistry; Humans; | 2013 |
Delay to formalin fixation 'cold ischemia time': effect on ERBB2 detection by in-situ hybridization and immunohistochemistry.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Cold Ischemia; Cytodiagnosis; Female; Fixatives; Formal | 2013 |
Oncogenic PIK3CA mutations in lobular breast cancer progression.
Topics: Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Lobular; Class I Phosphatidylinositol 3-Kinases; Dis | 2013 |
Droplet Digital™ PCR quantitation of HER2 expression in FFPE breast cancer samples.
Topics: Breast Neoplasms; Centromere; Female; Fixatives; Formaldehyde; Gene Dosage; Gene Expression; Humans; | 2013 |
Quantitative assessment of effect of preanalytic cold ischemic time on protein expression in breast cancer tissues.
Topics: A Kinase Anchor Proteins; Biomarkers, Tumor; Biopsy, Large-Core Needle; Breast Neoplasms; Cold Ische | 2012 |
Chromogenic in situ hybridization (CISH) to detect HER2 gene amplification in breast and gastric cancer: comparison with immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH).
Topics: Biomarkers, Tumor; Breast Neoplasms; Female; Formaldehyde; Gene Amplification; Genes, erbB-2; Humans | 2012 |
Analysis of gene alterations of mitochondrial DNA D-loop regions to determine breast cancer clonality.
Topics: Adult; Aged; Breast Neoplasms; Chromosomes, Human, X; Clone Cells; DNA, Mitochondrial; Female; Forma | 2012 |
Droplet digital PCR measurement of HER2 copy number alteration in formalin-fixed paraffin-embedded breast carcinoma tissue.
Topics: Breast Neoplasms; Computers; Female; Formaldehyde; Gene Dosage; Genetic Techniques; Humans; Paraffin | 2013 |
Role of deregulated microRNAs in breast cancer progression using FFPE tissue.
Topics: Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Noninfiltrating; Cell L | 2013 |
The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2.
Topics: Alkaline Phosphatase; Binding Sites; Breast Neoplasms; Cell Division; Chromatin; Cisplatin; Cross-Li | 2002 |
Evaluation of HER-2/neu immunohistochemical assay sensitivity and scoring on formalin-fixed and paraffin-processed cell lines and breast tumors: a comparative study involving results from laboratories in 21 countries.
Topics: Breast Neoplasms; Carcinoma; Female; Fixatives; Formaldehyde; Humans; Immunohistochemistry; Laborato | 2002 |
[Comparative analysis of various biochemical and immunohistochemical methods for evaluating hormone receptors in breast carcinoma].
Topics: Adsorption; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma; Charcoal; Dextrans; Estroge | 2002 |
Effect of fixation period on HER2/neu gene amplification detected by fluorescence in situ hybridization in invasive breast carcinoma.
Topics: Breast Neoplasms; Female; Fixatives; Formaldehyde; Gene Amplification; Genes, erbB-2; Humans; In Sit | 2002 |
A modified reduced-temperature antigen retrieval protocol effective for use with a polyclonal antibody to cyclooxygenase-2 (PG 27).
Topics: Antibodies; Antigens; Breast Neoplasms; Cyclooxygenase 2; Female; Formaldehyde; Hot Temperature; Hum | 2002 |
Minimum formalin fixation time for consistent estrogen receptor immunohistochemical staining of invasive breast carcinoma.
Topics: Biopsy, Needle; Breast Neoplasms; Carcinoma; Cell Count; Clinical Laboratory Techniques; Female; For | 2003 |
GEWF solution.
Topics: Acetic Acid; Breast Neoplasms; Ethanol; Formaldehyde; Humans; Indicators and Reagents; Lymph Node Ex | 2003 |
Interlaboratory comparison in HercepTest assessment of HER2 protein status in invasive breast carcinoma fixed with various formalin-based fixatives.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Breast Neoplasms; Female; Formaldehyde; Humans; Image In | 2003 |
Evaluation of oligonucleotide arrays for sequencing of the p53 gene in DNA from formalin-fixed, paraffin-embedded breast cancer specimens.
Topics: Breast Neoplasms; DNA, Neoplasm; Female; Fixatives; Formaldehyde; Humans; Mutation; Oligonucleotide | 2004 |
Design, synthesis, and biological evaluation of doxorubicin-formaldehyde conjugates targeted to breast cancer cells.
Topics: Antineoplastic Agents; Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Cell Line, | 2004 |
Amplification of the TOP2A gene does not predict high levels of topoisomerase II alpha protein in human breast tumor samples.
Topics: Antigens, Neoplasm; Breast Neoplasms; Chromosomes, Human, Pair 17; Data Interpretation, Statistical; | 2004 |
A fluorescence in situ hybridization study of ETV6-NTRK3 fusion gene in secretory breast carcinoma.
Topics: Adult; Aged; Breast Neoplasms; Carcinoma; Chromosome Breakage; Chromosome Mapping; Chromosomes, Huma | 2004 |
HER-2/neu detection in fine-needle aspirates of breast cancer: fluorescence in situ hybridization and immunocytochemical analysis.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Biopsy, Fine-Needle; Breast Neoplasms; Carcinoma, | 2004 |
Quantitative gene expression profiling in formalin-fixed, paraffin-embedded tissues using universal bead arrays.
Topics: Algorithms; Breast; Breast Neoplasms; Cell Line, Tumor; Cluster Analysis; Colon; Colonic Neoplasms; | 2004 |
Gene expression profiles in formalin-fixed, paraffin-embedded tissues obtained with a novel assay for microarray analysis.
Topics: Adenocarcinoma; Breast Neoplasms; Colonic Neoplasms; Female; Fixatives; Formaldehyde; Gene Expressio | 2004 |
Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells.
Topics: Antineoplastic Agents; Binding Sites; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Doxoru | 2004 |
Doxorubicin-formaldehyde conjugates targeting alphavbeta3 integrin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Adhesion; Cell Membrane; Cell | 2004 |
Array-based comparative genomic hybridization from formalin-fixed, paraffin-embedded breast tumors.
Topics: Breast Neoplasms; DNA, Neoplasm; Female; Fixatives; Formaldehyde; Humans; Nucleic Acid Amplification | 2005 |
Candidate genes in breast cancer revealed by microarray-based comparative genomic hybridization of archived tissue.
Topics: Breast Neoplasms; Chromosome Aberrations; Female; Formaldehyde; Genomic Instability; Humans; Nucleic | 2005 |
MALDI-TOF MS and TaqMan assisted SNP genotyping of DNA isolated from formalin-fixed and paraffin-embedded tissues (FFPET).
Topics: Alleles; Breast Diseases; Breast Neoplasms; DNA; DNA Mutational Analysis; DNA, Neoplasm; Female; For | 2005 |
DNA and RNA obtained from Bouin's fixed tissues.
Topics: Acetic Acid; Biological Specimen Banks; Breast Neoplasms; DNA Damage; DNA, Neoplasm; Female; Fixativ | 2005 |
[Influence of different antigen retrieval on the immunohistochemistry].
Topics: Antigens; Autoantigens; Breast Neoplasms; Citrates; Female; Formaldehyde; Hot Temperature; Humans; H | 2005 |
N2 laser excited autofluorescence spectroscopy of formalin-fixed human breast tissue.
Topics: Algorithms; Bayes Theorem; Breast; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Fixatives; F | 2005 |
A multiplex PCR predictor for aCGH success of FFPE samples.
Topics: Breast Neoplasms; DNA, Neoplasm; Female; Formaldehyde; Humans; Nucleic Acid Hybridization; Paraffin | 2006 |
Methods for gene expression profiling in clinical trials of adjuvant breast cancer therapy.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Chemotherapy, Adjuvant; Clinical Trials as Topic; | 2006 |
Antiprimer quenching-based real-time PCR and its application to the analysis of clinical cancer samples.
Topics: Apolipoproteins B; Breast Neoplasms; Colonic Neoplasms; DNA; DNA Primers; Female; Fixatives; Fluores | 2006 |
HER-2 status in breast cancer: correlation of gene amplification by FISH with immunohistochemistry expression using advanced cellular imaging system.
Topics: Breast Neoplasms; Female; Fixatives; Formaldehyde; Gene Amplification; Gene Expression Regulation, N | 2006 |
Development of new rabbit monoclonal antibody to progesterone receptor (Clone SP2): no heat pretreatment but effective for paraffin section immunohistochemistry.
Topics: Animals; Antibodies, Monoclonal; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Formaldehyde; | 2006 |
Direct detection of herceptin/trastuzumab binding on breast tissue sections.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Autoanalysis; Biotinylation; Breast Neopl | 2007 |
Classification of breast cancer using genetic algorithms and tissue microarrays.
Topics: Algorithms; Biomarkers, Tumor; Breast Neoplasms; Female; Fluorescent Antibody Technique; Formaldehyd | 2006 |
Quantitative protein analysis from formalin-fixed tissues: implications for translational clinical research and nanoscale molecular diagnosis.
Topics: Animals; Biomarkers, Tumor; Biopsy; Blotting, Western; Breast Neoplasms; Carcinoma; Female; Fixative | 2007 |
Automated array-CGH optimized for archival formalin-fixed, paraffin-embedded tumor material.
Topics: Automation; Biopsy, Needle; Breast Neoplasms; Cell Line, Tumor; DNA, Neoplasm; Female; Formaldehyde; | 2007 |
Genome-wide, high-resolution detection of copy number, loss of heterozygosity, and genotypes from formalin-fixed, paraffin-embedded tumor tissue using microarrays.
Topics: Breast Neoplasms; Carcinoma, Endometrioid; Chromosome Mapping; Colorectal Neoplasms; DNA, Neoplasm; | 2007 |
Effect of formaldehyde and resveratrol on the viability of Vero, HepG2 and MCF-7 cells.
Topics: Angiogenesis Inhibitors; Animals; Anti-Inflammatory Agents, Non-Steroidal; Breast Neoplasms; Carcino | 2007 |
Agreement in breast cancer classification between microarray and quantitative reverse transcription PCR from fresh-frozen and formalin-fixed, paraffin-embedded tissues.
Topics: Algorithms; Breast Neoplasms; Cryopreservation; Female; Fixatives; Formaldehyde; Humans; Oligonucleo | 2007 |
Molecular restoration of archived transcriptional profiles by complementary-template reverse-transcription (CT-RT).
Topics: Biological Specimen Banks; Breast Neoplasms; DNA Primers; DNA, Complementary; Female; Fixatives; For | 2007 |
Specimen shrinkage and its influence on margin assessment in breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Female; Fixatives; Formaldehyde; Humans; Mastectom | 2007 |
An immunohistochemical method for identifying fibroblasts in formalin-fixed, paraffin-embedded tissue.
Topics: Antibody Specificity; Breast Neoplasms; Connective Tissue Cells; Coronary Vessels; Enzyme-Linked Imm | 2008 |
YKL-40 expression in benign and malignant lesions of the breast: a methodologic study.
Topics: Adipokines; Adult; Aged; Breast; Breast Neoplasms; Carcinoma; Chitinase-3-Like Protein 1; Female; Fo | 2007 |
RNA extraction from ten year old formalin-fixed paraffin-embedded breast cancer samples: a comparison of column purification and magnetic bead-based technologies.
Topics: Breast Neoplasms; Female; Formaldehyde; Glucosephosphate Dehydrogenase; Humans; Immunomagnetic Separ | 2007 |
National HER2 proficiency test results using standardized quantitative controls: characterization of laboratory failures.
Topics: Artifacts; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Diagnostic Errors; Female | 2008 |
Quantitative expression profiling of highly degraded RNA from formalin-fixed, paraffin-embedded breast tumor biopsies by oligonucleotide microarrays.
Topics: Biopsy; Breast Neoplasms; Carcinoma, Ductal, Breast; Cell Line, Tumor; Female; Formaldehyde; Gene Ex | 2008 |
Optimization of RNA extraction from FFPE tissues for expression profiling in the DASL assay.
Topics: Breast Neoplasms; Formaldehyde; Gene Expression Profiling; Humans; Neoplasm Proteins; Oligonucleotid | 2008 |
Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue.
Topics: Breast Neoplasms; Cadherins; Collagen Type IV; Female; Fluorescent Antibody Technique; Formaldehyde; | 2008 |
On the synergistic effect of doxorubicin and mitomycin C against breast cancer cells.
Topics: Analysis of Variance; Antigens, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Breast Neo | 2007 |
The influence of formalin and paraffin embedding on the immunohistochemical reaction of monoclonal antibodies applied to female breast tissue.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Breast; Breast Neoplasms; Epitopes; Female; Formaldehyde | 1984 |
Effects of fixation and enzymatic digestion on the immunohistochemical demonstration of laminin and fibronectin in paraffin embedded tissue.
Topics: Acetates; Acetic Acid; Breast; Breast Neoplasms; Ethanol; Female; Fibronectins; Fixatives; Formaldeh | 1984 |
Biochemical assessment of histochemical methods for oestrogen receptor localisation.
Topics: Acetone; Breast Neoplasms; Cell Line; Estradiol; Female; Fixatives; Fluorescent Antibody Technique; | 1982 |
Cellular and subcellular localization of polyamines cytochemical methods providing new clues to polyamine function in normal and neoplastic cells.
Topics: Animals; Breast Neoplasms; Female; Fluorescamine; Formaldehyde; Histocytochemistry; Humans; Male; Me | 1982 |
Beta 1 and beta 4 integrin expression in methacarn and formalin-fixed material from in situ ductal carcinoma of the breast.
Topics: Acetates; Acetic Acid; Breast; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Ductal, Breast; Chlor | 1993 |
Immunohistochemical quantitation of oestrogen receptors and proliferative activity in oestrogen receptor positive breast cancer.
Topics: Antibodies, Monoclonal; Biomarkers, Tumor; Breast Neoplasms; Cell Division; Female; Formaldehyde; Hu | 1995 |
Vimentin expression in benign and malignant breast epithelium.
Topics: Adenofibroma; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Epitheli | 1993 |
Immunohistochemical detection of P-glycoprotein in normal and malignant tissues: a comparative study of three monoclonal antibodies, JSB-1, C 219 and 265/F4, against different epitopes using frozen and paraffin tissue sections.
Topics: Antibodies, Monoclonal; Ascitic Fluid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brea | 1993 |
Amplification of the MDM2 gene in human breast cancer and its association with MDM2 and p53 protein status.
Topics: Blotting, Southern; Breast Neoplasms; Breast Neoplasms, Male; Carcinoma in Situ; Carcinoma, Ductal, | 1995 |
A new immunohistochemical antibody for the assessment of estrogen receptor status on routine formalin-fixed tissue samples.
Topics: Adult; Aged; Antibodies, Monoclonal; Breast Neoplasms; Female; Formaldehyde; Humans; Immunohistochem | 1995 |
Wet autoclave pretreatment improves the visualization of silver-stained nucleolar organizer-region-associated proteins in routinely formalin-fixed and paraffin-embedded tissues.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; Formaldehyde; Histocy | 1994 |
Microwave processing for immunohistochemical demonstration of proliferating cell nuclear antigen (PCNA) in formalin-fixed and paraffin-embedded tissue.
Topics: Breast Neoplasms; Carcinoma; Fixatives; Formaldehyde; Humans; Immunohistochemistry; Male; Microwaves | 1994 |
Assessment of proliferating cell nuclear antigen (PCNA) in breast cancer using anti-PCNA PC10 and 19A2: correlation with 5-bromo-2'-deoxyuridine or tritiated thymidine labeling and flow cytometric analysis.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Bromodeoxyuridine; Cell Division; Flow Cytometry; Formalde | 1994 |
Improved technique for analysis of formalin-fixed, paraffin-embedded tumors by fluorescence in situ hybridization.
Topics: Breast Neoplasms; Centromere; Chromatin; Chromosomes, Human; DNA Probes; DNA, Neoplasm; Formaldehyde | 1994 |
Aberrant RB gene expression in routinely processed, archival tumor tissues determined by three different anti-RB antibodies.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Female; Formaldehyde; Gene Expression; Genes, Retinoblasto | 1994 |
The influence of tissue processing on quantitative histopathology in breast cancer.
Topics: Breast Neoplasms; Carcinoma; Cell Nucleus; Female; Formaldehyde; Humans; Mitotic Index; Prospective | 1994 |
Prognostic significance of a formalin-resistant nuclear proliferation antigen in mammary carcinomas as determined by the monoclonal antibody Ki-S1.
Topics: Adult; Aged; Antibodies, Monoclonal; Antigens, Neoplasm; Breast Neoplasms; Carcinoma; Drug Resistanc | 1993 |
Characterization of human breast biopsy specimens with near-IR Raman spectroscopy.
Topics: Biopsy; Breast; Breast Neoplasms; Carotenoids; Female; Formaldehyde; Humans; Lipids; Mammaplasty; Ma | 1994 |
Methodology of immunohistological detection of oestrogen receptor in human breast carcinoma in formalin-fixed, paraffin-embedded tissue: a comparison with frozen section methodology.
Topics: Adenocarcinoma; Adult; Aged; Antibodies, Monoclonal; Breast Neoplasms; Female; Formaldehyde; Frozen | 1993 |
Immunocytochemical p53 detection by microwave oven heating of routinely formalin-fixed paraffin sections.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Microwaves; Neoplasm Proteins; Paraffin Embedding; T | 1993 |
[Analysis of estrogen receptors in mammary carcinomas. Is immunocytochemical determination after formalin fixation sufficient?].
Topics: Antibodies, Monoclonal; Breast Neoplasms; Female; Fixatives; Formaldehyde; Humans; Immunoenzyme Tech | 1993 |
Immunocytochemical assay for estrogen receptor with monoclonal antibody D753P gamma in routinely processed formaldehyde-fixed breast tissue. Comparison with frozen section assay and with monoclonal antibody H222.
Topics: Antibodies, Monoclonal; Breast; Breast Neoplasms; Female; Formaldehyde; Frozen Sections; Humans; Imm | 1993 |
Comparison of flow and image cytometry for DNA content analysis of fresh and formalin-fixed, paraffin-embedded tissue in breast carcinoma.
Topics: Adenocarcinoma, Mucinous; Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Intraductal, Nonin | 1995 |
Estrogen and progesterone receptor status determined by the Ventana ES 320 automated immunohistochemical stainer and the CAS 200 image analyzer in 236 early-stage breast carcinomas: prognostic significance.
Topics: Aged; Automation; Biopsy, Needle; Breast Neoplasms; Carcinoma; Carcinoma, Ductal, Breast; Charcoal; | 1996 |
Microcalcifications in breast core biopsy specimens: disappearance at radiography after storage in formaldehyde.
Topics: Biopsy; Breast; Breast Neoplasms; Calcinosis; Electrolytes; Ethanol; Female; Formaldehyde; Humans; I | 1996 |
Multiple drug resistance-related messenger RNA expression in archival formalin-fixed paraffin-embedded human breast tumour tissue.
Topics: Adult; Base Sequence; Breast Neoplasms; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female | 1996 |
Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization.
Topics: Blotting, Northern; Blotting, Southern; Blotting, Western; Breast Neoplasms; DNA, Neoplasm; Female; | 1996 |
Genetic heterogeneity of primary and metastatic breast carcinoma defined by fluorescence in situ hybridization.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma; Cell Nucleus; Chromosome Aberrations; F | 1996 |
Plasma membrane phosphotyrosine, Her2-NEU, and epidermal growth factor receptor in human breast cancer. A comparative study.
Topics: Breast Neoplasms; Cell Nucleus; Cytoplasm; Epidermal Growth Factor; Epithelium; ErbB Receptors; Fema | 1996 |
Immunostaining of estrogen receptor, progesterone receptor, MIB1 antigen, and c-erbB-2 oncoprotein in cytologic specimens: a simplified method with formalin fixation.
Topics: Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Female; Fibroadenoma; Fixatives; For | 1997 |
Comparison of formalin, ethanol, and Histochoice fixation on the PCR amplification from paraffin-embedded breast cancer tissue.
Topics: Breast Neoplasms; Ethanol; Female; Fixatives; Formaldehyde; Histocytochemistry; Humans; Paraffin Emb | 1997 |
DNA ploidy analysis in breast carcinoma. Comparison of unfixed and fixed tissue analyzed by image and flow cytometry.
Topics: Breast Neoplasms; Carcinoma in Situ; Carcinoma, Ductal, Breast; DNA, Neoplasm; Female; Fixatives; Fl | 1997 |
Modified formalin and methanol fixation methods for molecular biological and morphological analyses.
Topics: Breast; Breast Neoplasms; Colon; Colonic Neoplasms; DNA; Fixatives; Formaldehyde; Gastric Mucosa; Hu | 1997 |
Sequential flow cytometry and fluorescence in situ hybridization for the study of formalin-fixed, paraffin-embedded breast cancer cells.
Topics: Breast Neoplasms; Flow Cytometry; Formaldehyde; Humans; In Situ Hybridization, Fluorescence; Interph | 1998 |
Quantitative analysis by gas chromatography of volatile carbonyl compounds in expired air from mice and human.
Topics: Acetaldehyde; Acetone; Adult; Aged; Animals; Breast Neoplasms; Breath Tests; Carcinoma; Chromatograp | 1997 |
Immunoperoxidase staining for estrogen and progesterone receptors in archival formalin fixed, paraffin embedded breast carcinomas after microwave antigen retrieval.
Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Breast Neoplasms; Charcoal; Dextrans; Female; Fo | 1997 |
The genomic sequences bound to special AT-rich sequence-binding protein 1 (SATB1) in vivo in Jurkat T cells are tightly associated with the nuclear matrix at the bases of the chromatin loops.
Topics: Base Composition; Base Sequence; Binding Sites; Breast Neoplasms; Chromatin; Cross-Linking Reagents; | 1998 |
Simultaneous detection of p53 nuclear protein and chromosome aberrations on sections from formalin-fixed, paraffin-embedded breast cancer tissue.
Topics: Breast Neoplasms; Chromosome Aberrations; Chromosomes, Human, Pair 17; Female; Formaldehyde; Humans; | 1998 |
Flow cytometric DNA analysis with cytokeratin gating of formalin-fixed deparaffinized breast cancer nuclei.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Cell Nucleus; DNA, Neoplasm; Female; Fixatives; Flow Cytom | 1998 |
Heat pretreatment increases resolution in DNA flow cytometry of paraffin-embedded tumor tissue.
Topics: Breast Neoplasms; Cell Separation; Colon; Colorectal Neoplasms; Dose-Response Relationship, Drug; Fl | 1999 |
Detection of surface antigen 17-1A in breast and colorectal cancer.
Topics: Antibodies, Monoclonal; Antigens, Neoplasm; Breast Neoplasms; Colorectal Neoplasms; Female; Formalde | 1999 |
Flow cytometric analysis of estrogen, progesterone receptor expression and DNA content in formalin-fixed, paraffin-embedded human breast tumors.
Topics: Breast Neoplasms; Carcinoma, Ductal, Breast; Carcinoma, Lobular; DNA, Neoplasm; Female; Fixatives; F | 1999 |
E-cadherin and beta-catenin expression in breast medullary carcinomas.
Topics: Adult; Aged; beta Catenin; Breast Neoplasms; Cadherins; Carcinoma, Ductal, Breast; Carcinoma, Medull | 1999 |
Semiquantitative assessment of c-erbB-2 (HER-2) status in cytology specimens and tissue sections from breast carcinoma.
Topics: Adenocarcinoma; Air; Biopsy, Needle; Breast Neoplasms; Ethanol; Female; Fixatives; Formaldehyde; Hum | 1999 |
Proliferation assessment in breast cancer: a double-staining technique for AgNOR quantification in MIB-1 positive cells especially adapted for image cytometry.
Topics: Adenocarcinoma; Antigens, Nuclear; Breast Neoplasms; Cell Division; Female; Formaldehyde; Humans; Im | 2000 |
Policy guidelines for the utilization of formalin-fixed, paraffin-embedded tissue sections: the UNC SPORE experience. University of North Carolina Specialized Program of Research Excellence.
Topics: Breast Neoplasms; Female; Fixatives; Formaldehyde; Humans; Paraffin Embedding; Quality Control; Spec | 1999 |
Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs.
Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Breast Neoplasms; Cross-Linking Reagent | 2000 |
Method for cloning in vivo targets of the Egr-1 transcription factor.
Topics: Binding Sites; Breast Neoplasms; Cloning, Molecular; Cross-Linking Reagents; DNA; DNA-Binding Protei | 2000 |
Assessment of methods for tissue-based detection of the HER-2/neu alteration in human breast cancer: a direct comparison of fluorescence in situ hybridization and immunohistochemistry.
Topics: Adult; Breast Neoplasms; Female; Formaldehyde; Gene Amplification; Gene Expression; Genes, erbB-2; H | 2000 |
Automated immunohistochemical staining of formalin-fixed and paraffin-embedded tissues using a catalyzed signal amplification method.
Topics: Antigens; Breast Neoplasms; Colonic Neoplasms; Fixatives; Formaldehyde; Humans; Immunohistochemistry | 2001 |
Routine formaldehyde fixation irreversibly reduces immunoreactivity of Bcl-2 in the nuclear compartment of breast cancer cells, but not in the cytoplasm.
Topics: Animals; Antibodies, Monoclonal; bcl-2-Associated X Protein; Breast Neoplasms; Cell Nucleus; Cytopla | 2001 |
Mutations of tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1) and receptor 2 (TRAIL-R2) genes in metastatic breast cancers.
Topics: Apoptosis; Breast Neoplasms; Carcinoma, Ductal, Breast; Chromosomes, Human, Pair 10; Chromosomes, Hu | 2001 |
Detection of progesterone receptor forms A and B by immunohistochemical analysis.
Topics: Animals; Antibodies; Breast Neoplasms; Carcinoma, Ductal, Breast; COS Cells; Endometrium; Female; Fo | 2001 |
Urokinase plasminogen activator is localized in stromal cells in ductal breast cancer.
Topics: Antibody Specificity; Biomarkers, Tumor; Breast Neoplasms; Carcinoma, Ductal, Breast; Detergents; En | 2001 |
Amplification of c-myc oncogene by chromogenic and fluorescence in situ hybridization in archival breast cancer tissue array samples.
Topics: Archives; Breast Neoplasms; Colorimetry; Female; Fixatives; Formaldehyde; Genes, myc; Humans; In Sit | 2001 |
Molecular basis for the synergistic interaction of adriamycin with the formaldehyde-releasing prodrug pivaloyloxymethyl butyrate (AN-9).
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Breast Neoplasms; | 2001 |
Methylation analysis of formalin-fixed, paraffin-embedded sections using a nontoxic DNA extraction protocol.
Topics: Animals; Breast Neoplasms; DNA Methylation; DNA, Neoplasm; Female; Fixatives; Formaldehyde; Humans; | 2001 |
A formalin-fixed, paraffin-processed cell line standard for quality control of immunohistochemical assay of HER-2/neu expression in breast cancer.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Immunohistochemistry; In Situ Hybridization, Fluores | 2002 |
Protein overexpression and gene amplification of c-erbB-2 in breast carcinomas: a comparative study of immunohistochemistry and fluorescence in situ hybridization of formalin-fixed, paraffin-embedded tissues.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Female; F | 2002 |
Effect of prolonged formalin fixation on the immunohistochemical reactivity of breast markers.
Topics: Biomarkers, Tumor; Breast Neoplasms; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p27; Fix | 2002 |
Formaldehyde-fluorescamine-induced fluorescence of mammary carcinoma cells. Lack of concordance with occurrence of oestrogen-binding receptor proteins.
Topics: Breast Neoplasms; Female; Fluorescamine; Fluorescence; Formaldehyde; Humans; Neoplasm Proteins; Rece | 1979 |
Immunofluorescence studies on formalin-fixed and paraffin-embedded material.
Topics: Adult; Breast Neoplasms; Child, Preschool; Female; Fluorescent Antibody Technique; Formaldehyde; His | 1977 |
Formalinized tumour cells in the leucocyte migration inhibition test.
Topics: Antigens, Neoplasm; Breast Neoplasms; Cell Migration Inhibition; Formaldehyde; Humans; Leukocytes; M | 1975 |
Estimation of tumor growth fractions in archival formalin-fixed, paraffin-embedded tissues using two anti-PCNA/Cyclin monoclonal antibodies. Factors affecting reactivity.
Topics: Antibodies, Monoclonal; Biomarkers, Tumor; Breast Neoplasms; Cyclins; Epitopes; Flow Cytometry; Form | 1992 |
Etiology of breast carcinoma: no apparent role for papillomavirus types 6/11/16/18.
Topics: Base Sequence; Biopsy; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Papilla | 1992 |
Estrogen and progesterone receptor detection in archival formalin-fixed, paraffin-embedded tissue from breast carcinoma: a comparison of immunohistochemistry with the dextran-coated charcoal assay.
Topics: Breast Neoplasms; Charcoal; Dextrans; Female; Formaldehyde; Humans; Immunohistochemistry; Paraffin; | 1992 |
[Human breast cancer embedded in paraffin, fixed in Bouin's fluid. Immunohistochemical analysis of estrogen and progesterone receptors].
Topics: Acetates; Acetic Acid; Breast Neoplasms; Female; Formaldehyde; Humans; Immunohistochemistry; Paraffi | 1991 |
Estrogen receptor in primary breast cancer estimated in paraffin-embedded tissue. A study of its usefulness compared to dextran-coated charcoal assay.
Topics: Breast Neoplasms; Female; Formaldehyde; Humans; Menopause; Paraffin Embedding; Prognosis; Receptors, | 1991 |
Quantification of estrogen receptors on paraffin-embedded tumors by image analysis.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Female; Formaldehyde; Humans; Image Processing, Computer-A | 1991 |
Oestrogen receptor staining of paraffin-embedded breast carcinomas following short fixation in formalin: a comparison with cytosolic and frozen section receptor analyses.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Cytosol; | 1990 |
Cross-linking of estrogen receptor to chromatin in intact MCF-7 human breast cancer cells: optimization and effect of ligand.
Topics: Breast Neoplasms; Centrifugation, Density Gradient; Chromatin; Cross-Linking Reagents; DNA; Estradio | 1990 |
Towards microfluorometric quantitation of polyamines in situ. Relationship between cellular polyamine concentration and fluorescence yield of the formaldehyde fluorescamine method.
Topics: Breast Neoplasms; Cytophotometry; Fluorescamine; Fluorescence; Formaldehyde; HeLa Cells; Humans; Met | 1990 |
Immunohistochemical detection of progesterone receptor in formalin-fixed and paraffin-embedded breast cancer tissue using a monoclonal antibody.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Female; Formaldehyde; Humans; Immunohistochemistry; Paraff | 1990 |
Immunohistochemical demonstration of estrogen receptors (ER) in formalin-fixed, paraffin-embedded human breast cancer tissue by use of a monoclonal antibody to ER.
Topics: Animals; Antibodies, Monoclonal; Breast Neoplasms; Epithelium; Female; Fixatives; Formaldehyde; Hist | 1988 |
[Immunocytochemical staining of estrogen receptor in conventional formalin-fixed paraffin sections in human breast cancer].
Topics: Adult; Aged; Aged, 80 and over; Antibodies, Monoclonal; Breast Neoplasms; Charcoal; Dextrans; Female | 1989 |
Effects of several commonly used fixatives on DNA and total nuclear protein analysis by flow cytometry.
Topics: Adenocarcinoma; Breast Neoplasms; Carcinoma, Squamous Cell; Colonic Neoplasms; DNA; Fixatives; Flow | 1989 |
Studies on immunoglobulin gene rearrangement in formalin-fixed, paraffin-embedded pathology specimens.
Topics: Breast Neoplasms; DNA; Female; Formaldehyde; Humans; Immunoglobulin kappa-Chains; Immunoglobulin lam | 1988 |
Demonstration of estrogen receptors by monoclonal antibody in formalin-fixed breast tumors.
Topics: Adult; Aged; Alkaline Phosphatase; Antibodies, Monoclonal; Breast Neoplasms; Female; Formaldehyde; H | 1988 |
Semiquantitative oestrogen receptor assay in formalin-fixed paraffin sections of human breast cancer tissue using monoclonal antibodies.
Topics: Antibodies, Monoclonal; Breast Neoplasms; Female; Fixatives; Formaldehyde; Humans; Immunoenzyme Tech | 1986 |
Letter: Formalin-fixed tumour cells in the leukocyte migration test.
Topics: Antigens, Neoplasm; Breast Neoplasms; Cell Migration Inhibition; Formaldehyde; Immunity, Cellular; L | 1973 |
[On the importance of fixation and staining for the determination of sec chromatin in breast carcinoma biopsy and in normal breast autopsy material].
Topics: Autopsy; Breast Neoplasms; Diagnosis, Differential; Female; Formaldehyde; Histological Techniques; H | 1968 |
Formalin treatment for massive bladder hemorrhage. Complications.
Topics: Adult; Breast Neoplasms; Cyclophosphamide; Cystitis; Dermatologic Surgical Procedures; Female; Forma | 1973 |
Sodium thymolphthalein monophosphate: a new acid phosphatase substrate with greater specificity for the prostatic enzyme in serum.
Topics: Acid Phosphatase; Biliary Tract Diseases; Blood Platelets; Bone and Bones; Breast Neoplasms; Erythro | 1971 |