formaldehyde has been researched along with Anemia, Fanconi in 10 studies
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy
| Excerpt | Relevance | Reference |
|---|---|---|
| "FANCD2 is required for the repair of DNA damage by the FA (Fanconi anemia) pathway, and, consequently, FANCD2-deficient cells are sensitive to compounds such as cisplatin and formaldehyde that induce DNA:DNA and DNA:protein crosslinks, respectively." | 3.80 | Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells. ( Campbell, JL; Hendrickson, EA; Karanja, KK; Lee, EH, 2014) |
| "Fanconi Anemia (FA) is a rare, genome instability-associated disease characterized by a deficiency in repairing DNA crosslinks, which are known to perturb several cellular processes, including DNA transcription, replication, and repair." | 1.91 | A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene. ( Blondeau, A; Coulombe, Y; Dessapt, J; Duxin, JP; Fradet-Turcotte, A; Gao, Y; Guitton-Sert, L; Hussein, S; Larsen, NB; Masson, JY; Milano, L; Rodrigue, A, 2023) |
| "Formaldehyde (FA) is a ubiquitous endogenous and environmental metabolite that is thought to exert cytotoxicity through DNA and DNA-protein crosslinking, likely contributing to the onset of the human DNA repair condition Fanconi Anaemia." | 1.72 | Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity. ( Bollini, M; Crossan, GP; Fernández, GA; Kolesnikova, K; Martinefski, MR; Monge, ME; Morellato, AE; Pak, O; Pontel, LB; Reingruber, H; Rieckher, M; Scheidegger, MA; Schumacher, B; Sommer, N; Umansky, C, 2022) |
| "Formaldehyde is an aliphatic monoaldehyde and is a highly reactive environmental human carcinogen." | 1.34 | Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde. ( Arakawa, H; Bishop, DK; Buerstedde, JM; Gillespie, DA; Luke, AM; Nakamura, A; Nakamura, J; Ridpath, JR; Sale, JE; Sonoda, E; Swenberg, JA; Takata, M; Takeda, S; Tano, K; Watanabe, M; Yamazoe, M, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 5 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Umansky, C | 1 |
| Morellato, AE | 1 |
| Rieckher, M | 1 |
| Scheidegger, MA | 1 |
| Martinefski, MR | 1 |
| Fernández, GA | 1 |
| Pak, O | 1 |
| Kolesnikova, K | 1 |
| Reingruber, H | 1 |
| Bollini, M | 1 |
| Crossan, GP | 2 |
| Sommer, N | 1 |
| Monge, ME | 1 |
| Schumacher, B | 1 |
| Pontel, LB | 1 |
| Gao, Y | 1 |
| Guitton-Sert, L | 1 |
| Dessapt, J | 1 |
| Coulombe, Y | 1 |
| Rodrigue, A | 1 |
| Milano, L | 1 |
| Blondeau, A | 1 |
| Larsen, NB | 1 |
| Duxin, JP | 1 |
| Hussein, S | 1 |
| Fradet-Turcotte, A | 1 |
| Masson, JY | 1 |
| Takata, M | 3 |
| Zhao, Y | 1 |
| Wei, L | 1 |
| Tagmount, A | 1 |
| Loguinov, A | 1 |
| Sobh, A | 1 |
| Hubbard, A | 1 |
| McHale, CM | 2 |
| Chang, CJ | 2 |
| Vulpe, CD | 1 |
| Zhang, L | 2 |
| Shen, X | 1 |
| Wang, R | 1 |
| Kim, MJ | 1 |
| Hu, Q | 1 |
| Hsu, CC | 1 |
| Yao, J | 1 |
| Klages-Mundt, N | 1 |
| Tian, Y | 1 |
| Lynn, E | 1 |
| Brewer, TF | 1 |
| Zhang, Y | 1 |
| Arun, B | 1 |
| Gan, B | 1 |
| Andreeff, M | 1 |
| Takeda, S | 2 |
| Chen, J | 1 |
| Park, JI | 1 |
| Shi, X | 1 |
| Jung, SY | 1 |
| Qin, J | 1 |
| Li, L | 1 |
| Karanja, KK | 1 |
| Lee, EH | 1 |
| Hendrickson, EA | 1 |
| Campbell, JL | 1 |
| Rosado, IV | 1 |
| Langevin, F | 1 |
| Patel, KJ | 1 |
| Ren, X | 1 |
| Ji, Z | 1 |
| Yuh, J | 1 |
| Bersonda, J | 1 |
| Tang, M | 1 |
| Smith, MT | 1 |
| Ridpath, JR | 1 |
| Nakamura, A | 1 |
| Tano, K | 1 |
| Luke, AM | 1 |
| Sonoda, E | 1 |
| Arakawa, H | 1 |
| Buerstedde, JM | 1 |
| Gillespie, DA | 1 |
| Sale, JE | 1 |
| Yamazoe, M | 1 |
| Bishop, DK | 1 |
| Watanabe, M | 1 |
| Swenberg, JA | 1 |
| Nakamura, J | 1 |
| Speit, G | 1 |
| Schütz, P | 1 |
| Merk, O | 1 |
10 other studies available for formaldehyde and Anemia, Fanconi
| Article | Year |
|---|---|
Endogenous formaldehyde scavenges cellular glutathione resulting in redox disruption and cytotoxicity.
Topics: Aldehyde Oxidoreductases; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disease | 2022 |
A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene.
Topics: CRISPR-Cas Systems; DNA; DNA Damage; DNA Repair; DNA Repair Enzymes; DNA Replication; Drug Tolerance | 2023 |
[A new Fanconi anemia-like disorder, aldehyde degradation deficiency syndrome: two defense mechanisms working together for the genome and hematopoiesis].
Topics: Aldehyde Dehydrogenase, Mitochondrial; Aldehydes; Child; Defense Mechanisms; Fanconi Anemia; Formald | 2023 |
Applying genome-wide CRISPR to identify known and novel genes and pathways that modulate formaldehyde toxicity.
Topics: Animals; Clustered Regularly Interspaced Short Palindromic Repeats; Fanconi Anemia; Formaldehyde; Hu | 2021 |
A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia.
Topics: Cell Differentiation; Cellular Reprogramming; DNA Damage; DNA Repair; Fanconi Anemia; Formaldehyde; | 2020 |
Preventing over-resection by DNA2 helicase/nuclease suppresses repair defects in Fanconi anemia cells.
Topics: Cell Line, Tumor; Cisplatin; DNA Breaks, Double-Stranded; DNA Helicases; DNA Repair; Fanconi Anemia; | 2014 |
Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.
Topics: Aldehyde Oxidoreductases; Animals; Cell Line; Chickens; DNA Repair; Fanconi Anemia; Fanconi Anemia C | 2011 |
The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines.
Topics: Apoptosis; Cell Line; Chromosome Aberrations; DNA; Dose-Response Relationship, Drug; Fanconi Anemia; | 2013 |
Cells deficient in the FANC/BRCA pathway are hypersensitive to plasma levels of formaldehyde.
Topics: Acetaldehyde; Acrolein; Aldehydes; Animals; BRCA1 Protein; Cell Cycle; Cell Survival; Chickens; Cros | 2007 |
Induction and repair of formaldehyde-induced DNA-protein crosslinks in repair-deficient human cell lines.
Topics: Cell Line; Cross-Linking Reagents; DNA; DNA Repair; Fanconi Anemia; Formaldehyde; Humans; Micronucle | 2000 |