Page last updated: 2024-10-18

formaldehyde and Amyotrophic Lateral Sclerosis

formaldehyde has been researched along with Amyotrophic Lateral Sclerosis in 15 studies

paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy

Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)

Research Excerpts

ExcerptRelevanceReference
"The aim of this study was to determine whether patients with amyotrophic lateral sclerosis (ALS) exhibit higher plasma levels of formaldehyde (FA) than controls, and to look for alterations in levels of FA precursors."7.96Plasma from some patients with amyotrophic lateral sclerosis exhibits elevated formaldehyde levels. ( Arachchige, BJ; Aylward, J; Henderson, R; Lee, A; McCombe, PA; Reed, S, 2020)
"Prior studies have yielded inconsistent evidence regarding the association between formaldehyde exposure and amyotrophic lateral sclerosis (ALS)."7.85Occupational formaldehyde and amyotrophic lateral sclerosis. ( Gredal, O; Hansen, J; Kioumourtzoglou, MA; Seals, RM; Weisskopf, MG, 2017)
"The aim of this study was to determine whether patients with amyotrophic lateral sclerosis (ALS) exhibit higher plasma levels of formaldehyde (FA) than controls, and to look for alterations in levels of FA precursors."3.96Plasma from some patients with amyotrophic lateral sclerosis exhibits elevated formaldehyde levels. ( Arachchige, BJ; Aylward, J; Henderson, R; Lee, A; McCombe, PA; Reed, S, 2020)
"Prior studies have yielded inconsistent evidence regarding the association between formaldehyde exposure and amyotrophic lateral sclerosis (ALS)."3.85Occupational formaldehyde and amyotrophic lateral sclerosis. ( Gredal, O; Hansen, J; Kioumourtzoglou, MA; Seals, RM; Weisskopf, MG, 2017)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19901 (6.67)18.7374
1990's1 (6.67)18.2507
2000's5 (33.33)29.6817
2010's5 (33.33)24.3611
2020's3 (20.00)2.80

Authors

AuthorsStudies
Embacher, N1
Kaufmann, WA1
Beer, R1
Maier, H1
Jellinger, KA1
Poewe, W1
Ransmayr, G1
Newell, ME1
Adhikari, S1
Halden, RU1
Lee, A1
Arachchige, BJ1
Reed, S1
Henderson, R1
Aylward, J1
McCombe, PA1
Bellavia, A1
Dickerson, AS1
Rotem, RS1
Hansen, J2
Gredal, O2
Weisskopf, MG3
Seals, RM1
Kioumourtzoglou, MA1
Spencer, PS1
Pinkerton, LE1
Hein, MJ1
Meyers, A1
Kamel, F1
Wakabayashi, K1
Mori, F1
Kakita, A1
Takahashi, H1
Utsumi, J1
Sasaki, H1
Roberts, AL1
Johnson, NJ1
Cudkowicz, ME1
Eum, KD1
Beaulieux, F1
Berger, MM1
Tcheng, R1
Giraud, P1
Lina, B1
Gellein, K1
Garruto, RM1
Syversen, T1
Sjøbakk, TE1
Flaten, TP1
Usarek, E1
Gajewska, B1
Kaźmierczak, B1
Kuźma, M1
Dziewulska, D1
Barańczyk-Kuźma, A1
Kuehn, BM1
Dawson, G1
Stefansson, K1
Abe, K1
Fujimura, H1
Kobayashi, Y1
Fujita, N1
Yanagihara, T1

Reviews

1 review available for formaldehyde and Amyotrophic Lateral Sclerosis

ArticleYear
Systematic and state-of the science review of the role of environmental factors in Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's Disease.
    The Science of the total environment, 2022, Apr-15, Volume: 817

    Topics: Amyotrophic Lateral Sclerosis; Animals; Formaldehyde; Humans; Mercury; Mice; Selenium; Zinc

2022

Other Studies

14 other studies available for formaldehyde and Amyotrophic Lateral Sclerosis

ArticleYear
Apoptosis signals in sporadic amyotrophic lateral sclerosis: an immunocytochemical study.
    Acta neuropathologica, 2001, Volume: 102, Issue:5

    Topics: Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Apoptosis; bcl-2 Homologous Antagonist-Kille

2001
Plasma from some patients with amyotrophic lateral sclerosis exhibits elevated formaldehyde levels.
    Journal of the neurological sciences, 2020, Feb-15, Volume: 409

    Topics: Aged; Amyotrophic Lateral Sclerosis; Biomarkers; Female; Formaldehyde; Humans; Male; Methylamines; M

2020
Joint and interactive effects between health comorbidities and environmental exposures in predicting amyotrophic lateral sclerosis.
    International journal of hygiene and environmental health, 2021, Volume: 231

    Topics: Amyotrophic Lateral Sclerosis; Case-Control Studies; Environmental Exposure; Female; Formaldehyde; H

2021
Occupational formaldehyde and amyotrophic lateral sclerosis.
    European journal of epidemiology, 2017, Volume: 32, Issue:10

    Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Case-Control Studies; Denmark; Employment; Female; Forma

2017
Formaldehyde, DNA damage, ALS and related neurodegenerative diseases.
    Journal of the neurological sciences, 2018, 08-15, Volume: 391

    Topics: Amyotrophic Lateral Sclerosis; DNA Damage; Formaldehyde; Humans; Neurodegenerative Diseases

2018
Assessment of ALS mortality in a cohort of formaldehyde-exposed garment workers.
    Amyotrophic lateral sclerosis & frontotemporal degeneration, 2013, Volume: 14, Issue:5-6

    Topics: Amyotrophic Lateral Sclerosis; Cohort Studies; Female; Fixatives; Formaldehyde; Humans; Male; Occupa

2013
Analysis of microRNA from archived formalin-fixed paraffin-embedded specimens of amyotrophic lateral sclerosis.
    Acta neuropathologica communications, 2014, Dec-14, Volume: 2

    Topics: Adaptor Proteins, Signal Transducing; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Anteri

2014
Job-related formaldehyde exposure and ALS mortality in the USA.
    Journal of neurology, neurosurgery, and psychiatry, 2016, Volume: 87, Issue:7

    Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Cohort Studies; Female; Formaldehyde; Humans; Longitudin

2016
RNA extraction and RT-PCR procedures adapted for the detection of enterovirus sequences from frozen and paraffin-embedded formalin-fixed spinal cord samples.
    Journal of virological methods, 2003, Volume: 107, Issue:2

    Topics: Amyotrophic Lateral Sclerosis; Cryopreservation; Enterovirus; Enterovirus Infections; Formaldehyde;

2003
Concentrations of Cd, Co, Cu, Fe, Mn, Rb, V, and Zn in formalin-fixed brain tissue in amyotrophic lateral sclerosis and Parkinsonism-dementia complex of Guam determined by High-resolution ICP-MS.
    Biological trace element research, 2003,Winter, Volume: 96, Issue:1-3

    Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Animals; Brain Chemistry; Cattle; Dementia; Female; Form

2003
A study of glutathione S-transferase pi expression in central nervous system of subjects with amyotrophic lateral sclerosis using RNA extraction from formalin-fixed, paraffin-embedded material.
    Neurochemical research, 2005, Volume: 30, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Amyotrophic Lateral Sclerosis; Blotting, Western; Case-Control Studi

2005
Researchers identify neurological risks.
    JAMA, 2008, May-28, Volume: 299, Issue:20

    Topics: Abattoirs; Alcohol Drinking; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Cholinergic

2008
Gangliosides of human spinal cord: aberrant composition of cords from patients with amyotrophic lateral sclerosis.
    Journal of neuroscience research, 1984, Volume: 12, Issue:2-3

    Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Chromatography, Thin Layer; Female; Fixatives; Formaldeh

1984
Degeneration of the pyramidal tracts in patients with amyotrophic lateral sclerosis. A premortem and postmortem magnetic resonance imaging study.
    Journal of neuroimaging : official journal of the American Society of Neuroimaging, 1997, Volume: 7, Issue:4

    Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Axons; Cadaver; Case-Control Studies; Female; Fixatives;

1997