formaldehyde has been researched along with Ache in 1329 studies
paraform: polymerized formaldehyde; RN given refers to parent cpd; used in root canal therapy
| Excerpt | Relevance | Reference |
|---|---|---|
| "These electrophysiological studies, using desensitization and selective antagonists, demonstrate a peripheral role of bradykinin in the generation of pain in the rat." | 8.78 | Electrophysiological approaches to the study of bradykinin and nitric oxide in inflammatory pain. ( Chapman, V; Dickenson, A; Haley, J; Schachter, M, 1992) |
| "Different nociceptive models induced with heat and chemicals were used to assess the potency of emodin in alleviating pain." | 8.31 | Emodin Reduces Inflammatory and Nociceptive Responses in Different Pain-and Inflammation-Induced Mouse Models. ( Guan, L; Li, J; Zhang, X, 2023) |
| " Recently, a rat reserpine-induced pain model showing exaggerated pain-related behaviors to mechanical and thermal stimuli has been used in FM research." | 8.12 | Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. ( Ejiri, Y; Mizumura, K; Ota, H; Taguchi, T; Uta, D, 2022) |
| "Sprague-Dawley rats were used to test the analgesic effect of pentazocine and neostigmine using the paw formalin pain model and the incision mechanical allodynia model." | 8.12 | Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats. ( Bai, X; Guo, J; Huang, H; Ouyang, H; Wu, S; Zhang, K, 2022) |
| " To evaluate the analgesic effects of AC, 4 different pain models including hot plate assay, acetic acid writhing assay, formalin and CFA induced pain models were adopted in this study." | 8.02 | Comparison of analgesic activities of aconitine in different mice pain models. ( Chen, J; Deng, J; Feng, Q; Han, J; Huang, Q; Leung, EL; Liu, Z; Lu, L; Qi, X; Wang, D; Wang, Y; Zhang, Y, 2021) |
| "Cannabidiol, the major non-psychoactive constituent of Cannabis, has attracted much attention as a therapeutic agent for intractable chronic pain in many conditions." | 8.02 | Cannabidiol microinjection into the nucleus accumbens attenuated nociceptive behaviors in an animal model of tonic pain. ( Haghparast, A; Keyhanfar, F; Rashvand, M; Razavi, Y; Sharifi, A, 2021) |
| "It can be concluded that the benzylamine derivative of phencyclidine with a methyl group on the benzyl position on phenyl ring (V) is a more appropriate candidate to reduce acute and chronic (thermal and chemical) pains compared to other substituted phenyl analogs (II-IV) and PCP." | 7.91 | New Amine and Aromatic Substituted Analogues of Phencyclidine: Synthesis and Determination of Acute and Chronic Pain Activities. ( Ahmadi, A; Khalili, M; Samadizadeh, M; Shokrollahi, M; Sobhanian, SA, 2019) |
| "Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain." | 7.91 | Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain. ( Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E, 2019) |
| "To unravel the underlying mechanism of minocycline in formalin-induced inflammatory pain, and to investigate the effects of minocycline on synaptic transmission in substantia gela-tinosa (SG) neurons of rat spinal dorsal horn." | 7.88 | [Minocycline inhibits formalin-induced inflammatory pain and the underlying mechanism]. ( Cheng, XE; Feng, XJ; Hu, XX; Jiang, CY; Liu, T; Ma, LX; Peng, HZ, 2018) |
| "The non-steroidal anti-inflammatory drug celecoxib has long been used for reducing pain, in spite of moderate gastrointestinal side effects." | 7.85 | The Analgesic Effects of Celecoxib on the Formalin-induced Short- and Long-term Inflammatory Pain. ( Guo, XJ; Liang, JC; Sun, Y; Tang, K; Wang, HY; Wang, Y; Wang, YT; Yin, JB; Zhao, YQ, 2017) |
| "Sex differences in the analgesic effects of morphine have been previously reported in various models that represent the sensory component of pain." | 7.85 | Dissociation of morphine analgesic effects in the sensory and affective components of formalin-induced spontaneous pain in male and female rats. ( Armendariz, A; Harton, LR; Nazarian, A; Richardson, JR, 2017) |
| " In this study, the possible modulatory role of cobalt (II) chloride (CoCl2) on low level Pb exposure on tail immersion test and formalin induced pain was investigated." | 7.85 | Effect of Low Dose Lead (Pb) Administration on Tail Immersion Test and Formalin-induced Pain in Wistar Rats: Possible Modulatory Role of Cobalt (II) Chloride. ( Muhammed, H; Suleiman, I; Umar, AH, 2017) |
| "This study aimed to investigate the involvement of opioid receptors in the systemic and peripheral antinociceptive activities of montelukast in different animal models of pain." | 7.83 | Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain. ( Alboghobeish, S; Ghorbanzadeh, B; Mansouri, MT; Sahraei, H, 2016) |
| "The present study was aimed to investigate the effects of microinjection of histamine and its H1, H2 and H3 receptor antagonists, mepyramine, ranitidine and thioperamide, respectively, into the anterior cingulate cortex (ACC) on pain-related behaviors induced by formalin in rats." | 7.81 | Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats. ( Farshid, AA; Hamzeh-Gooshchi, N; Tamaddonfard, E, 2015) |
| " We propose the research and development of therapeutic approaches for preemptive, short- and long-term management of cancer pain using available drugs or nutraceutical agents that can suppress or neutralize lactic acid production in combination with formaldehyde scavengers." | 7.81 | Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. ( Fang, JY; Han, B; Hoang, BX; Nimni, M; Shaw, DG, 2015) |
| "This study examined the short- and long-term neuroprotective and analgesic activity of honokiol (a naturally occurring lignan isolated from Magnolia) on developing brains in neonates exposed to inflammatory pain, known to cause neuronal cell death." | 7.81 | Honokiol for the Treatment of Neonatal Pain and Prevention of Consequent Neurobehavioral Disorders. ( Chen, D; Espinera, A; García, PS; Gu, X; Lee, JH; Wei, L; Woodbury, A; Yu, SP; Zhang, J, 2015) |
| "This study aimed to investigate whether LSD1 in metastasized MRMT-1 breast cancer cells in bone marrows participated in the production of endogenous formaldehyde in bone cancer pain rats." | 7.79 | Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats. ( Cai, J; Chen, W; Li, H; Li, ZH; Liao, FF; Liu, FY; Liu, J; Luo, HJ; Luo, WH; Tang, JM; Tang, Y; Tong, ZQ; Wan, Y, 2013) |
| "In the present study, we have investigated the anti-nociceptive and anti-allodynic activity of the renin inhibitor, aliskiren, in various pain models." | 7.79 | Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models. ( Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM, 2013) |
| " Opioid coadministration had a synergistic effect in the acute tonic pain (acetic acid writhing test), acute phasic pain (tail flick test) and inflammatory pain (orofacial formalin test)." | 7.79 | Systemic synergism between codeine and morphine in three pain models in mice. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Zepeda, RJ, 2013) |
| "To study the effects of neonatal pain and morphine treatment on the developing brain in a neonatal rat model." | 7.79 | Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain. ( Bendix, I; Boos, V; Dührsen, L; Dzietko, M; Felderhoff-Mueser, U; Genz, K; Sifringer, M; Simons, SH; Tibboel, D, 2013) |
| "Tolerance to morphine analgesia following repeated administration disturbs the continuation of opioid therapy for severe pain." | 7.78 | Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms. ( Fukazawa, Y; Iwai, S; Kiguchi, N; Kishioka, S; Kobayashi, Y; Saika, F; Ueno, K; Yamamoto, C, 2012) |
| " In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model." | 7.78 | Antinociceptive effects of intrathecal landiolol injection in a rat formalin pain model. ( Itano, Y; Kaku, R; Kanzaki, H; Matsuoka, Y; Mizobuchi, S; Morita, K; Nishie, H; Obata, N; Ouchida, M; Taniguchi, A; Tomotsuka, N, 2012) |
| "Endothelin-1 (ET-1) has been suggested to be involved in different types of pain due to its neuromodulatory nature." | 7.78 | Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection. ( Chen, AY; Chen, SM; Cheung, CW; Chung, SK; Hung, VK; Tai, LW, 2012) |
| "To investigate the expression of protein kinase C (PKC) in the spinal dorsal horn of rats with formalin-induced pain and the effect of intrathecal ketamine on PKC expression." | 7.77 | [Effect of intrathecal ketamine injection on protein kinase C expression in the spinal dorsal horn of rats with formalin-induced pain]. ( GUO, QL; WANG, E; YAN, JQ; YANG, Y; ZOU, WY, 2011) |
| "Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception." | 7.77 | Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011) |
| "The effect of morphine is often studied in the absence of pain, and it remains poorly understood if and how noxious stimulation may change the activity state of descending pain-modulatory pathways and their response to morphine." | 7.76 | Visualizing acute pain-morphine interaction in descending monoamine nuclei with Fos. ( Bajic, D; Commons, KG, 2010) |
| "Milnacipran and duloxetine, serotonin/noradrenalin reuptake inhibitors, and pregabalin, a alpha(2)-delta(1) Ca(2+) channel blocker, are efficacious against fibromyalgia, a condition characterized by diffuse chronic pain and associated with stress." | 7.76 | Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats. ( Aliaga, M; Bardin, L; Depoortère, R; Gregoire, S; Ladure, P; Malfetes, N; Newman-Tancredi, A; Vitton, O, 2010) |
| "Z-360, a novel cholecystokinin(2) (CCK(2)) receptor antagonist, has been developed as a therapeutic drug for pancreatic cancer and showed pain relief action in phase Ib/IIa clinical trial." | 7.76 | Pharmacological evaluation of analgesic effects of the cholecystokinin2 receptor antagonist Z-360 in mouse models of formalin- and cancer-induced pain. ( Eta, R; Hamano, H; Hori, Y; Horii, T; Kawabata, Y; Kuraishi, Y; Orikawa, Y; Ozaki, T; Seto, K; Takei, M; Yoshii, K; Yoshinaga, K, 2010) |
| " Accumulated evidence shows that endogenous formaldehyde concentrations are elevated in the blood or urine of patients with breast, prostate or bladder cancer." | 7.76 | Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. ( Duan, B; Han, Y; Li, H; Liu, F; Luo, H; Luo, W; Maoying, Q; Tan, H; Tong, Z; Wan, Y; Wang, J; Wang, Y; Xu, T; Yang, F; Zhao, H, 2010) |
| "The inhibitory transmitters GABA and glycine play an important role in modulating pain transmission, both in normal and in pathological situations." | 7.76 | Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. ( Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç, 2010) |
| " The purpose of this study on male rats was to determine the effects of a single injection of morphine (5 mg/Kg) on persistent pain (formalin test) and the single or combined effects on p450-aromatase and 5-alpha reductase type 1 mRNA expression in the brain, liver and testis." | 7.76 | Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats. ( Aloisi, AM; Anzini, M; Cappelli, A; Ceccarelli, I; Danielli, B; Fiorenzani, P; Giordano, A; Maddalena, M; Rossi, A; Rovini, M; Sorda, G; Tomei, V, 2010) |
| " In the present study, we focus on the influence of the maternal corticosterone milieu and its role in the effects of stress during pregnancy on formalin-induced pain and the corticosterone response to it in male and female offspring of different ages." | 7.75 | Effects of maternal corticosterone and stress on behavioral and hormonal indices of formalin pain in male and female offspring of different ages. ( Aloisi, AM; Bagaeva, T; Butkevich, I; Mikhailenko, V; Otellin, V; Semionov, P, 2009) |
| "The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain." | 7.75 | Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009) |
| " Formalin-induced pain-related behaviour and c-Fos expression in the trigeminal caudal nucleus (Vc) with/without systemic preadministration of a gamma-aminobutyric acid (GABA) type A receptor antagonist, bicuculline (2 mg/kg, i." | 7.75 | Effects of systemic bicuculline or morphine on formalin-evoked pain-related behaviour and c-Fos expression in trigeminal nuclei after formalin injection into the lip or tongue in rats. ( Abe, T; Kobayashi, M; Satoh, F; Sugiyo, S; Takemura, M; Uehashi, D; Yonehara, N, 2009) |
| "The aim of this study was to establish the effect of lidocaine, a local anesthetic, on pain and itch using formalin-induced nociception and kappa opioid antagonist-induced scratching models in mice." | 7.75 | Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5'-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence. ( Cowan, A; Dun, NJ; Inan, S, 2009) |
| "To evaluate the effect of intrathecal pumping tramadol on cell-mediated immunity in rats with formalin inflammatory pain." | 7.74 | [Effect of intrathecal pumping tramadol on the immune function in rats with formalin pain]. ( Cai, J; Guo, QL; Wang, E; Wang, YC; Xu, DM; Yang, HW; Zou, WY, 2008) |
| "We evaluated the effects of zonisamide on inflammatory and neuropathic pain using the mouse formalin test and streptozotocin (STZ)-induced diabetic mice with a reduced withdrawal threshold to mechanical stimuli, respectively." | 7.74 | Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy. ( Murakami, T; Ono, H; Tanabe, M, 2008) |
| "Amygdalin is a plant glucoside isolated from the stones of rosaceous fruits, such as apricots, peaches, almond, cherries, and plums." | 7.74 | Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats. ( Hahm, DH; Hwang, HJ; Kim, CJ; Kim, P; Lee, HJ; Shim, I; Yang, Y; Yin, CS, 2008) |
| "In the current study we compared the potency of the selective metabotropic glutamate receptor (mGluR1) antagonist A-841720 (7-Azepan-1-yl-4-dimethylamino-7H-9-thia-1,5,7-triaza-fluoren-8-one) in rodent models of pain with its effects in models of learning and memory, to obtain information regarding the therapeutic window of this compound." | 7.74 | Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. ( Barberi, C; Belozertseva, I; Danysz, W; Gravius, A; Malyshkin, A; Morè, L; Pietraszek, M; Schaefer, D; Schmidt, WJ; Shekunova, E, 2007) |
| "One of the possible sites of action of the analgesic effect of morphine is the Nucleus Raphe Magnus, as morphine injected into this structure induces analgesia in transient pain models." | 7.74 | Analgesia induced by morphine microinjected into the nucleus raphe magnus: effects on tonic pain. ( Dallel, R; Dualé, C; Sierralta, F, 2007) |
| "Calcitonin gene-related peptide (CGRP) and substance P (SP) play an important role in the development of pain and hyperalgesia." | 7.74 | Role of calcitonin gene-related peptide and substance P in different models of pain. ( Buscone, S; Di Bella, P; Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2008) |
| "Recent clinical studies have demonstrated that when morphine is used to control pain in cancer patients, psychological dependence is not a major concern." | 7.73 | Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state. ( Ise, Y; Kishimoto, Y; Misawa, K; Narita, M; Suzuki, T; Yajima, Y, 2005) |
| "Intrathecally administered edaravone, a free radical scavenger, had analgesic effects on inflammatory-induced acute and facilitated pain but not on acute thermal pain, without any behavioural side-effects." | 7.73 | Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats. ( Nishiyama, T; Ogawa, M, 2005) |
| "Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia." | 7.73 | Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity. ( Lee, IH; Lee, IO, 2005) |
| "To evaluate the immunological function in rats with formalin inflammatory pain through intrathecal pumping different dosages of morphine." | 7.73 | [Effect of intrathecal pumping morphine on immunological function in rats with formalin pain]. ( Cai, J; Guo, QL; Wang, E; Zou, WY, 2005) |
| "We studied the effects of the high-efficacy 5-hydroxytryptamine1A (5-HT1A) receptor agonist, F 13640 on both formalin-induced spinal cord c-Fos protein expression and pain behaviours in the rat." | 7.73 | Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: a c-Fos study. ( Aliaga, M; Besson, JM; Buritova, J; Colpaert, F; Larrue, S, 2005) |
| "It has been demonstrated that spinal microglial activation is involved in formalin-induced pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral hypersensitivity in neuropathic pain models." | 7.73 | Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat. ( Cho, IH; Choi, SY; Chung, YM; Jung, SJ; Kim, D; Kim, JS; Lee, H; Lee, SJ; Li, HY; Oh, SB; Park, CK; Park, K; Park, SH; Piao, ZG, 2006) |
| "The present study tested the hypothesis that morphine exposure during the human developmental equivalent of the third trimester would alter inflammatory pain." | 7.73 | Acute and chronic morphine alters formalin pain in neonatal rats. ( Kendig, JJ; Sweitzer, SM; Zhang, G; Zissen, MH, 2006) |
| " As some anticonvulsant drugs also have anti-inflammatory activity, the effects of benzaldehyde semicarbazone (BS) on models of nociception, edema and angiogenesis were investigated." | 7.73 | Antinociceptive, antiedematogenic and antiangiogenic effects of benzaldehyde semicarbazone. ( Andrade, SP; Araújo, F; Beraldo, H; Bertollo, CM; Coelho, MM; Costa, KA; Nascimento, EB; Oliveira, AC; Rocha, LT; Teixeira, LR, 2006) |
| "Oxytocin has been implicated in the modulation of somatosensory transmission such as nociception and pain." | 7.73 | Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice. ( Chugh, C; Jain, H; Mediratta, PK; Rathi, N; Reeta, Kh; Sharma, KK, 2006) |
| " The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema." | 7.72 | Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003) |
| "In both acute thermal- and inflammatory-induced pain, intrathecally administered midazolam and bupivacaine produced synergistic analgesia with decreased side effects in intrathecally catheterized rats." | 7.72 | Midazolam can potentiate the analgesic effects of intrathecal bupivacaine on thermal- or inflammatory-induced pain. ( Hanaoka, K; Nishiyama, T, 2003) |
| "We investigated the interaction between spinally administered bupivacaine and clonidine using an animal model of acute and inflammatory pain." | 7.72 | Intrathecal clonidine and bupivacaine have synergistic analgesia for acute thermally or inflammatory-induced pain in rats. ( Hanaoka, K; Nishiyama, T, 2004) |
| "Melatonin, the major secretory product of pineal gland has been suggested to play a regulatory role in the circadian rhythm of body activities including the pain sensitivity." | 7.72 | Evaluation of the role of melatonin in formalin-induced pain response in mice. ( Mahajan, P; Mediratta, PK; Ray, M; Sharma, KK, 2004) |
| " We investigated here the effects of ketamine anesthesia on somatosensory processing in the rat spinal cord, thalamus, and cerebral cortex, using the quantitative 2-deoxyglucose mapping technique." | 7.72 | Effects of ketamine anesthesia on central nociceptive processing in the rat: a 2-deoxyglucose study. ( Baraldi, P; Cavazzuti, M; Giuliani, D; Lui, F; Porro, CA; Vellani, V, 2004) |
| "Intrathecal administration of propofol had analgesic effects on inflammation-induced acute and facilitated pain but not on thermally-induced acute pain." | 7.72 | Intrathecal propofol has analgesic effects on inflammation-induced pain in rats. ( Hanaoka, K; Matsukawa, T; Nishiyama, T, 2004) |
| "The present study examined the effects of local peripheral and systemic administration of three clinically used excitatory amino acid receptor antagonists (dextromethorphan, memantine, ketamine) on pain behaviors and edema produced by formalin (1." | 7.71 | Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. ( Reid, A; Sawynok, J, 2002) |
| "The effects of adenosine analogues on pain have been shown to depend on the subtype receptor involved as well as on the nociceptive stimuli and on the route of administration." | 7.71 | Formalin-induced pain and mu-opioid receptor density in brain and spinal cord are modulated by A1 and A2a adenosine agonists in mice. ( Borghi, V; Ilona, O; Labuz, D; Maj, M; Pavone, F; Przewlocka, B, 2002) |
| "To investigate the effect of essential oil of Radix Aangelicae Dahuricae (EOAD) on beta-endorphin Adrenocorticotropic hormone(ACTH), Nitric oxide (NO) and Proopiomelanocortin (POMC) of pain model rats induced by formaldehyde." | 7.71 | [Effect of essential oil of Radix Angelicae Dahuricae on beta-endorphin, ACTH, NO and proopiomelanocortin of pain model rats]. ( Nie, H; Shen, YJ, 2002) |
| "Spinally-administered midazolam, a benzodiazepine, and clonidine, an alpha2-adrenergic receptor agonist, have significant synergistic effects on thermally-induced acute and formalin-induced inflammatory pain." | 7.71 | The synergistic interaction between midazolam and clonidine in spinally-mediated analgesia in two different pain models of rats. ( Hanaoka, K; Nishiyama, T, 2001) |
| "An excess of excitatory pathway activation via N-methyl-D-aspartate (NMDA) receptors has been described in neuropathic pain that responds poorly to morphine." | 7.71 | Magnesium increases morphine analgesic effect in different experimental models of pain. ( Begon, S; Dubray, C; Eschalier, A; Pickering, G, 2002) |
| "In formalin pain model, the effect of propofol on Fos expression in the spinal cord was examined by means of c -fos oncogene immunohistochemistry and NADPH-d histochemistry." | 7.71 | [Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain]. ( Dai, TJ; Duan, SM; Yan, M; Zhang, LC; Zheng, YM, 2002) |
| "Peripherally administered nitric oxide itself has no analgesic effect, but it enhances the analgesic effects of peripherally administered morphine during inflammation induced by paw formalin injection in the rat." | 7.70 | The interaction of FK409, a novel nitric oxide releaser, and peripherally administered morphine during experimental inflammation. ( Nozaki-Taguchi, N; Yamamoto, T, 1998) |
| "The peptide neurotransmitter substance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is expressed by discrete populations of neurons throughout the central nervous system." | 7.70 | Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. ( Belmonte, C; Cervero, F; De Felipe, C; Doyle, CA; Herrero, JF; Hunt, SP; Laird, JM; O'Brien, JA; Palmer, JA; Smith, AJ, 1998) |
| " (1) The therapeutic effects of the cannabinoid anandamide and the putative CB2 agonist palmitoylethanolamide were tested in a model of persistent visceral pain (turpentine inflammation of the urinary bladder)." | 7.70 | The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. ( Hasnie, FS; Jaggar, SI; Rice, AS; Sellaturay, S, 1998) |
| "We previously reported that the morphine-induced place preference was attenuated under inflammation produced by the unilateral injection of 2." | 7.70 | Role of the kappa-opioid system in the attenuation of the morphine-induced place preference under chronic pain. ( Kishimoto, Y; Misawa, M; Nagase, H; Suzuki, T; Takeda, F, 1999) |
| "CNS correlates of acute prolonged pain, and the effects of partial blockade of the central beta-endorphin system, were investigated by the quantitative 2-deoxyglucose technique in unanaesthetized, freely moving rats." | 7.70 | CNS pattern of metabolic activity during tonic pain: evidence for modulation by beta-endorphin. ( Baraldi, P; Cavazzuti, M; Corazza, R; Giuliani, D; Panerai, AE; Porro, CA, 1999) |
| "In this study, we compared pain reduction produced by IV drugs (ketamine or alfentanil) with the ability to prevent injury-induced spinal cord changes." | 7.70 | Pre- versus postformalin effects of ketamine or large-dose alfentanil in the rat: discordance between pain behavior and spinal Fos-like immunoreactivity. ( Coderre, TJ; Gilron, I; Quirion, R, 1999) |
| ") gabapentin, administered before and after the injection of formalin into the rat hindpaw, on pain behavior and hemodynamics." | 7.70 | The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat. ( Yaksh, TL; Yoon, MH, 1999) |
| "To study the effect of tetrahydropalmatine (THP) analogs on Fos protein expression induced by formalin-pain and elucidate analgesic mechanism of THP analogs." | 7.70 | Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain. ( Hu, JY; Jin, GZ, 1999) |
| "This study investigates the antinociceptive and the oedema inhibition properties of the novel non-peptide bradykinin (BK) B2 receptor antagonist, NPC 18884." | 7.70 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| "The effect of a commonly used experimental pain-induction procedure (formalin injection into a hindpaw site) on morphine tolerance, withdrawal, and reward was examined in rats." | 7.70 | The role of formalin-induced pain in morphine tolerance, withdrawal, and reward. ( Bardin, L; Kim, JA; Siegel, S, 2000) |
| "This study examined the effects of hyperglycemia and treatment with the aldose reductase inhibitor, Tolrestat, on the pain behavior evoked by injection of formalin into the dorsum of a single hind paw." | 7.69 | Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. ( Calcutt, NA; Malmberg, AB; Yaksh, TL; Yamamoto, T, 1994) |
| "Pain associated-anxiety induced by formalin, which resulted in a significant delay in the development of tolerance to morphine antinociception, failed to prevent the development of physical dependence as evidenced by naloxone challenge." | 7.69 | Morphine dependence with or without tolerance in formalin-treated mice: further evidence for the dissociation. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 7.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "The aim of the present study was to investigate whether clonidine and morphine interact positively to produce analgesia against the low intensity tonic pain represented by the formalin model in rats." | 7.69 | Morphine, clonidine coadministration in subanalgesic doses: effective control of tonic pain. ( Gurtu, S; Mukerjee, D; Shukla, S, 1994) |
| "Possible central noradrenergic and cholinergic modulation of acute peripheral inflammation was investigated in rats, adopting the formaldehyde-induced pedal inflammation as the experimental model." | 7.69 | Central noradrenergic and cholinergic modulation of formaldehyde-induced pedal inflammation and nociception in rats. ( Dumka, VK; Raviprakash, V; Tandan, SK; Tripathi, HC, 1996) |
| "Morphine-, methamphetamine- and cocaine-induced place preferences under inflammation produced by unilateral injections of 2." | 7.69 | Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine. ( Kishimoto, Y; Misawa, M; Suzuki, T, 1996) |
| "Naloxone has been reported to affect pain and locomotor activity differently depending on the dose." | 7.69 | Influence of low and high doses of naloxone on tonic pain and motor activity in rats. ( Mathur, R; Mena, NB; Nayar, U, 1996) |
| "Possible central serotonergic and histaminergic modulation of acute peripheral inflammation was investigated in rats, adopting the formaldehyde-induced acute pedal inflammation as an experimental model." | 7.69 | Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats. ( Dumka, VK; Raviprakash, V; Tandan, SK; Tripathi, HC, 1996) |
| "We previously reported that morphine fails to produce analgesic tolerance when administered in the presence of formalin-induced pain, which may be related to activity of the hypothalamic-pituitary-adrenal axis." | 7.69 | The role of corticosterone in the blockade of tolerance to morphine analgesia by formalin-induced pain in the rat. ( Nores, WL; Olson, RD; Soignier, RD; Vaccarino, AL, 1997) |
| "The present study was designed to observe the effect of orphanin FQ (OFQ, also known as 'nociceptin'), a newly-discovered neuropeptide, on pain behavior and morphine analgesia evaluated by formalin test in rats." | 7.69 | Orphanin FQ potentiates formalin-induced pain behavior and antagonizes morphine analgesia in rats. ( Cao, XD; Wu, GC; Xu, SF; Zhu, CB, 1997) |
| "The possible influence of painful stimulation and morphine analgesia on hypothalamic met-enkephalin levels, and the possible correlation between this biochemical parameter and animal behaviour was studied." | 7.68 | Changes in hypothalamic met-enkephalin levels of rats induced by painful stimulation and morphine treatment. ( Ayala, J; Del Valle, M; Fuente, T; Hernández, LC; Iglesias, L; López, JM; Seijo, F, 1993) |
| "The present study examined the development of tolerance to morphine analgesia under conditions in which morphine was administered in the presence or absence of pain induced by subcutaneous injection of 50 microliters of 2." | 7.68 | Morphine fails to produce tolerance when administered in the presence of formalin pain in rats. ( Ben-Eliyahu, S; Couret, LC; Kao, B; Kest, B; Liebeskind, JC; Marek, P; Vaccarino, AL, 1993) |
| "A dose of 20 mg/kg of amitriptyline reduced pain in the second phase of the formalin test, which is an animal model of long-lasting pain in humans." | 7.68 | Amitriptyline produces analgesia in the formalin pain test. ( Acton, J; McKenna, JE; Melzack, R, 1992) |
| "The involvement of the beta-endorphin (B-EP) system during acute prolonged (tonic) pain was investigated by biochemical and behavioral approaches in freely-moving rats after subcutaneous injection of a small amount of a dilute formaldehyde solution (0." | 7.68 | Central beta-endorphin system involvement in the reaction to acute tonic pain. ( Carli, G; Facchinetti, F; Panerai, AE; Porro, CA; Tassinari, G, 1991) |
| "Application of capsaicin to the sciatic nerve reduces responsiveness to pain in the foot-flick test which examines brief, threshold-level pain." | 7.67 | Single nerve capsaicin: effects on pain and morphine analgesia in the formalin and foot-flick tests. ( Abbott, FV; Grimes, RW; Melzack, R, 1984) |
| "The effects of several cholinergic and dopaminergic agents on pain and morphine analgesia were assessed using three pain tests." | 7.66 | Effects of cholinergic and dopaminergic agents on pain and morphine analgesia measured by three pain tests. ( Dennis, SG; Melzack, R, 1983) |
| "Tolerance to morphine analgesia was examined using the Formalin test in which pain lasting about 2 hrs associated with minor tissue injury is produced by subcutaneous injection of dilute Formalin." | 7.66 | Apparent lack of tolerance in the formalin test suggests different mechanisms for morphine analgesia in different types of pain. ( Abbott, FV; Franklin, KB; Ludwick, RJ; Melzack, R, 1981) |
| "Paraformaldehyde based pulpal medicament can be used as an alternative to manage pain in patients having severe irreversible pulpitis and hyperalgesia." | 5.51 | Comparative evaluation of the effect of two pulpal medicaments on pain and bleeding status of mandibular molars with irreversible pulpitis post-failure of inferior alveolar nerve block: a double-blind, randomized, clinical trial. ( Kurniawati, N; Mishra, L; Pawar, AM; Singh, NR; Wahjuningrum, DA, 2022) |
| "treatment with oxyntomodulin during the second, but not the first phase." | 5.48 | Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models. ( Hong, JW; Jang, SP; Lee, HJ; Lee, JR; Park, SH; Suh, HW, 2018) |
| " Furthermore, DEX showed little neuro-toxicity on the spinal cord neurons, even at the highest dosage used in our study." | 5.46 | Dexmedetomidine relieves formaldehyde-induced pain in rats through both α2 adrenoceptor and imidazoline receptor. ( Leng, YF; Liu, YQ; Wan, ZH; Wang, DG; Yan, X; Zhang, H; Zhang, Y, 2017) |
| "Luteolin is a naturally occurring flavonoid with diverse pharmacological properties such as anti-inflammatory, antioxidant and anticancer." | 5.46 | Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice. ( Abdollahzadeh, M; Golmakani, E; Hashemzaei, M; Iranshahi, M; Rezaee, R; Tabrizian, K, 2017) |
| "Dehydrocorydaline (DHC) is an alkaloidal component isolated from Rhizoma corydalis." | 5.43 | Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. ( Chu, SS; Gu, XP; Li, L; Ma, ZL; Sun, Q; Yin, ZY, 2016) |
| "Gabapentin was found to reversibly decrease, but not suppress the flinching frequency of the second response peak only." | 5.40 | Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain. ( Danhof, M; Della Pasqua, O; Taneja, A; Troconiz, IF, 2014) |
| "Pain is a complex experience composed of sensory and affective components." | 5.39 | Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats. ( Hara, T; Ide, S; Kaneda, K; Koseki, K; Maruyama, C; Minami, M; Naka, T; Ohno, A; Tamano, R; Yoshioka, M, 2013) |
| "SA daily treatment significantly reduced mechanical allodynia in KOR and cannabinoid receptor 1 (CB1R) sensitive manner." | 5.38 | Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection. ( Aviello, G; Boccella, S; Capasso, R; De Chiaro, M; de Novellis, V; Gatta, L; Guida, F; Izzo, AA; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Zjawiony, JK, 2012) |
| " Chronic administration of minocycline (40 and 80 mg/kg, i." | 5.37 | Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms. ( Dua, K; Kulkarni, SK; Pabreja, K; Padi, SS; Sharma, S, 2011) |
| "NA-3,4-DCM, dosed systemically (intraperitoneally or per os), was capable of interfering with the development of mechanical hypernociception induced by intraplantar injection of carrageenan and complete Freund adjuvant in mice." | 5.36 | N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system. ( Antonialli, CS; Corrêa, R; da Silva, GF; de Campos-Buzzi, F; Filho, VC; Quintão, NL, 2010) |
| "It had less effect on tactile allodynia (CCI)." | 5.35 | Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008) |
| "Morphine pretreatment produced an increase in GABA levels and a decrease in glutamate levels in the first few minutes." | 5.35 | [Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain]. ( Hernández, L; Páez, X; Quiñones, B; Silva, E, 2008) |
| "Since pain is the main syndrome of dysmenorrhea, the present investigation was carried out to evaluate the analgesic activity of LIG in vivo." | 5.34 | Ligustilide attenuates pain behavior induced by acetic acid or formalin. ( Du, J; Ke, Y; Qian, ZM; Wang, C; Yu, Y; Zhu, L, 2007) |
| " Furthermore, A-425619 maintained efficacy in the postoperative pain model after twice daily dosing p." | 5.33 | A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. ( El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ, 2005) |
| "Lacosamide is a functionalized amino acid which was initially synthesized as an antiepileptic drug." | 5.33 | Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain. ( Krause, E; Selve, N; Stöhr, T, 2006) |
| "Ambroxol's effects were compared with those of gabapentin." | 5.33 | Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005) |
| "Neuropathic pain is a debilitating condition affecting millions of people around the world and is defined as pain that follows a lesion or dysfunction of the nervous system." | 5.33 | Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. ( Bramwell, S; Corradini, L; Cox, PJ; Dolphin, AC; England, S; Field, MJ; Hendrich, J; Kinloch, RA; Melrose, H; Offord, J; Stott, E; Su, TZ; Webb, T; Williams, D; Winks, J, 2006) |
| "Corticosterone plasma levels were increased by formalin only in estrogen-treated animals, independently of naloxone." | 5.31 | Role of gonadal hormones in formalin-induced pain responses of male rats: modulation by estradiol and naloxone administration. ( Aloisi, AM; Ceccarelli, I, 2000) |
| " formalin, enhanced the second-but not the first-phase nociceptive responses, whereas it was without significant effects at 3 micrograms per paw, and conversely, produced antinociception at 10 micrograms per paw, resulting in a bell-shaped dose-response curve." | 5.29 | Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation. ( Kawabata, A; Manabe, S; Manabe, Y; Takagi, H, 1994) |
| "25% formalin and shifted the dose-response relation for the effect of morphine on the second phase of the pain response produced by 1." | 5.29 | The effect of lesions of the dorsolateral funiculus on formalin pain and morphine analgesia: a dose-response analysis. ( Abbott, FV; Franklin, KBJ; Hong, Y, 1996) |
| ") against chemically induced cutaneous pain in rats, was assessed from cumulative dose-response experiments and the formalin test." | 5.28 | Analgesia produced by intrathecal administration of the kappa opioid agonist, U-50,488H, on formalin-evoked cutaneous pain in the rat. ( Hernández, A; Paeile, C; Pelissier, T; Saavedra, H; Soto-Moyano, R, 1990) |
| "Alcohol and formaldehyde significantly reduced all measures of heel pain, and analgesia was evident over the 112 days of the study." | 5.19 | Analgesic effects of intraneural injection of ethyl alcohol or formaldehyde in the palmar digital nerves of horses. ( Adams, TP; Bertone, AL; Ishihara, A; Oglesbee, M; Schneider, CP; Zekas, LJ, 2014) |
| "These electrophysiological studies, using desensitization and selective antagonists, demonstrate a peripheral role of bradykinin in the generation of pain in the rat." | 4.78 | Electrophysiological approaches to the study of bradykinin and nitric oxide in inflammatory pain. ( Chapman, V; Dickenson, A; Haley, J; Schachter, M, 1992) |
| "Different nociceptive models induced with heat and chemicals were used to assess the potency of emodin in alleviating pain." | 4.31 | Emodin Reduces Inflammatory and Nociceptive Responses in Different Pain-and Inflammation-Induced Mouse Models. ( Guan, L; Li, J; Zhang, X, 2023) |
| "Several clinical studies have reported the analgesic effect of curcumin (Curc) in various situations such as rheumatoid arthritis, osteoarthritis, and postsurgical pain." | 4.31 | Epidural Administration of Curcumin-Loaded Polycaprolactone/Gelatin Electrospun Nanofibers for Extended Analgesia After Laminectomy in Rats. ( Barkhordari, A; Esmaeilizadeh, N; Han, Y; Jalil, AT; Jiang, T; Pilehvar, Y; Saleh, MM; Talaei, S, 2023) |
| " In the formalin test, none of the compounds are as effective as phencyclidine at the earliest time-point, but compounds IV and V show effectiveness during the second stage of formalin pain." | 4.12 | Synthesis and Antinociceptive Activity of Newly Modified Amine Analogs of Phencyclidine in Mice. ( Ahmadi, A; Khalili, M; Samadizadeh, M; Shokrollahi, M; Sobhanian, SA, 2022) |
| " Recently, a rat reserpine-induced pain model showing exaggerated pain-related behaviors to mechanical and thermal stimuli has been used in FM research." | 4.12 | Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model. ( Ejiri, Y; Mizumura, K; Ota, H; Taguchi, T; Uta, D, 2022) |
| "Sprague-Dawley rats were used to test the analgesic effect of pentazocine and neostigmine using the paw formalin pain model and the incision mechanical allodynia model." | 4.12 | Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats. ( Bai, X; Guo, J; Huang, H; Ouyang, H; Wu, S; Zhang, K, 2022) |
| " To evaluate the analgesic effects of AC, 4 different pain models including hot plate assay, acetic acid writhing assay, formalin and CFA induced pain models were adopted in this study." | 4.02 | Comparison of analgesic activities of aconitine in different mice pain models. ( Chen, J; Deng, J; Feng, Q; Han, J; Huang, Q; Leung, EL; Liu, Z; Lu, L; Qi, X; Wang, D; Wang, Y; Zhang, Y, 2021) |
| " For mechanism investigation, it was used hot plate test to induce opioid receptors, a histamine and serotonin test to induce edema paw, finally, for the TRPV1 receptor, it was used the capsaicin test." | 4.02 | Pharmacological studies on aqueous extract of Launaea arborescens from southwest Algeria. ( Belboukhari, N; Cheriti, A; Ould El Hadj-Khelil, A; Seddiki, LS; Sekkoum, K; Sulaiman, MR, 2021) |
| " The acetylcholinesterase inhibitor (ACHEI); neostigmine, is known clinically for its analgesic effect in the perioperative phases proving high efficacy; besides possessing anti-inflammatory properties controlling immune cells and cytokine level." | 4.02 | The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation. ( Abdel-Bary, A; El-Tahan, RA; Gowayed, MA, 2021) |
| "Cannabidiol, the major non-psychoactive constituent of Cannabis, has attracted much attention as a therapeutic agent for intractable chronic pain in many conditions." | 4.02 | Cannabidiol microinjection into the nucleus accumbens attenuated nociceptive behaviors in an animal model of tonic pain. ( Haghparast, A; Keyhanfar, F; Rashvand, M; Razavi, Y; Sharifi, A, 2021) |
| "In this study, four monomers derived from Corydalis yanhusuo (tetrahydropalmatine, corydaline, protopine, dehydrocorydaline) were tested in vivo, using the formalin-induced pain model to determine their analgesic properties." | 4.02 | Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels. ( Li, W; Liu, Y; Lv, K; Su, Y; Sun, J; Teng, Y; Xu, Y; Yang, L; Zhang, J; Zhang, S; Zhao, M, 2021) |
| " AMWD was subjected to activity testing, using chemical-induced (acetic acid and formalin test) and heat-induced (hot plate) pain models." | 4.02 | Allium macrostemon Bunge. exerts analgesic activity by inhibiting NaV1.7 channel. ( Dai, Y; Fu, W; Han, C; Ji, Z; Xu, Y; Yang, X; Zhang, X, 2021) |
| "Role of NADPH oxidase1 in the development of inflammatory pain has been demonstrated by gene knockout studies." | 3.96 | NADPH oxidase1 inhibition leads to regression of central sensitization during formalin induced acute nociception via attenuation of ERK1/2-NFκB signaling and glial activation. ( Kumar, S; Vinayak, M, 2020) |
| "The present study investigated the effects of intrathecal nefopam on the pain behavior and on the extracellular levels of serotonin (5-HT), norepinephrine (NE), and glutamate in the spinal cord, in a rat model of pain induced by formalin." | 3.96 | Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord. ( Chae, JW; Choi, JI; Kang, DH; Kim, SH; Kim, WM; Lee, HG; Li, Y; Yoon, MH, 2020) |
| " The plant extract at doses of 50, 100 and 150 mg/kg was tested for anti-inflammatory activity against carrageenan and egg albumin induced paw edema in mice and analgesic activity was appraised against acetic acid induced writhing and formalin induced paw licking in mice models." | 3.96 | Evaluation of anti-inflammatory and analgesic activities of aqueous methanolic extract of Ranunculus muricatus in albino mice. ( Alamgeer, -; Asif, H; Hasan, UH; Irfan, HM; Nasreen, P; Sharif, A; Uttra, AM; Younis, W, 2020) |
| " platensis on different types of pain and inflammation in comparison to diclofenac sodium." | 3.96 | Effects of Spirulina platensis on pain and inflammation in long Evans rats. ( Akhter, S; Ali, T; Nipa, NS; Rafiq, K, 2020) |
| "The results of the present study suggest that serotonergic and opioidergic systems are involved, at least in part, in the antinociceptive effect of the ketamine-magnesium sulphate combination in the model of inflammatory pain in rats." | 3.91 | Involvement of serotonergic and opioidergic systems in the antinociceptive effect of ketamine-magnesium sulphate combination in formalin test in rats. ( Divac, N; Medić, B; Prostran, M; Savić Vujović, K; Srebro, D; Stojanović, R; Vasović, D; Vučković, S, 2019) |
| "It can be concluded that the benzylamine derivative of phencyclidine with a methyl group on the benzyl position on phenyl ring (V) is a more appropriate candidate to reduce acute and chronic (thermal and chemical) pains compared to other substituted phenyl analogs (II-IV) and PCP." | 3.91 | New Amine and Aromatic Substituted Analogues of Phencyclidine: Synthesis and Determination of Acute and Chronic Pain Activities. ( Ahmadi, A; Khalili, M; Samadizadeh, M; Shokrollahi, M; Sobhanian, SA, 2019) |
| "Herein, it was investigated whether a complex of lidocaine with 2-hydroxypropyl-β-cyclodextrin (HP-β-CD) would present a better antinociceptive profile in vivo when compared with plain lidocaine in models of orofacial pain." | 3.91 | Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain. ( Araya, EI; Chichorro, JG; Claudino, RF; de Oliveira, SB; Ferreira, LEN; Franz-Montan, M; Gambeta, E, 2019) |
| "The aim of this study was to evaluate the effect of vitamin E co-administration with celecoxib in thermal and inflammatory pain in two model of pain assessment including thermal tail flick test of acute pain and formalin induced inflammatory model in adult male rats." | 3.91 | Evidence for antinociceptive effects of combined administration of vitamin E and celecoxib in tail-flick and formalin test in male rats. ( Izadi, G; Sepehri, G; Shamsi Meymandi, M; Zamiri, Z, 2019) |
| " Antinociceptive activity was detected in acetic acid-induced writhing, tail-immersion, and formalin tests, indicating interference with both non-inflammatory and inflammatory pain." | 3.88 | Saline extract of Pilosocereus gounellei stem has antinociceptive effect in mice without showing acute toxicity and altering motor coordination. ( da Silva, WAV; de Luna Freire, MO; de Medeiros, PL; de Melo Carvalho, B; de Oliveira, AM; Ferreira, MRA; Napoleão, TH; Paiva, PMG; Soares, LAL, 2018) |
| "To unravel the underlying mechanism of minocycline in formalin-induced inflammatory pain, and to investigate the effects of minocycline on synaptic transmission in substantia gela-tinosa (SG) neurons of rat spinal dorsal horn." | 3.88 | [Minocycline inhibits formalin-induced inflammatory pain and the underlying mechanism]. ( Cheng, XE; Feng, XJ; Hu, XX; Jiang, CY; Liu, T; Ma, LX; Peng, HZ, 2018) |
| "Eslicarbazepine acetate (ESL) is a novel dibenzazepine antiepileptic, that has demonstrated efficacy against trigeminal pain, both in preclinical and clinical studies." | 3.88 | Eslicarbazepine acetate reduces trigeminal nociception: Possible role of adrenergic, cholinergic and opioid receptors. ( Micov, A; Pecikoza, U; Stepanović-Petrović, R; Tomić, M, 2018) |
| " Isovaline is a novel prototype analgesic that produces peripheral antinociception in several pain models with little or no effect on the central nervous system." | 3.85 | Variations of isovaline structure related to activity in the formalin foot assay in mice. ( Asiri, YI; Fung, T; MacLeod, BA; Puil, E; Schwarz, SKW; Wall, R, 2017) |
| "The non-steroidal anti-inflammatory drug celecoxib has long been used for reducing pain, in spite of moderate gastrointestinal side effects." | 3.85 | The Analgesic Effects of Celecoxib on the Formalin-induced Short- and Long-term Inflammatory Pain. ( Guo, XJ; Liang, JC; Sun, Y; Tang, K; Wang, HY; Wang, Y; Wang, YT; Yin, JB; Zhao, YQ, 2017) |
| "Because ketamine and magnesium block NMDA receptor activation by distinct mechanisms of action, we hypothesized that in a model of inflammatory pain in rats the combination of ketamine and magnesium might be more effective than ketamine alone." | 3.85 | Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test. ( Knežević, N; Medić, B; Prostran, M; Vasović, D; Vučković, S; Vujović, KS, 2017) |
| "To assess the interaction between bullatine A and morphine on antinociception in acute nociception and pain hypersensitivity states, with the exogenous synthetic dynorphin A as a comparison MATERIALS AND METHODS: Spinal nerve ligation-induced neuropathic rats and naïve mice were used for assessing the acute and chronic interactions of bullatine A/dynorphin A with morphine." | 3.85 | Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors. ( Chen, Y; Huang, Q; Li, XY; Sun, ML; Wang, YX, 2017) |
| "Sex differences in the analgesic effects of morphine have been previously reported in various models that represent the sensory component of pain." | 3.85 | Dissociation of morphine analgesic effects in the sensory and affective components of formalin-induced spontaneous pain in male and female rats. ( Armendariz, A; Harton, LR; Nazarian, A; Richardson, JR, 2017) |
| "The extract was assessed for antinociceptive activity using chemical and heat induced pain models such as hot plate, tail immersion, acetic acid-induced writhing, formalin, glutamate, and cinnamaldehyde test models in mice at the doses of 100, 200, and 400 mg/kg (p." | 3.85 | Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice. ( Khan, MF; Khatun, A; Mannan, MA, 2017) |
| " In this study, the possible modulatory role of cobalt (II) chloride (CoCl2) on low level Pb exposure on tail immersion test and formalin induced pain was investigated." | 3.85 | Effect of Low Dose Lead (Pb) Administration on Tail Immersion Test and Formalin-induced Pain in Wistar Rats: Possible Modulatory Role of Cobalt (II) Chloride. ( Muhammed, H; Suleiman, I; Umar, AH, 2017) |
| " The analgesic, anti-inflammatory and anti-platelet activities were assessed using acetic acid and formalin-induced nociception in mice, carrageenan-induced rat paw edema and arachidonic acid-induced platelets aggregation tests." | 3.83 | Analgesic, anti-inflammatory and anti-platelet activities of Buddleja crispa. ( Bukhari, IA; Gilani, AH; Meo, SA; Saeed, A, 2016) |
| "This study aimed to investigate the involvement of opioid receptors in the systemic and peripheral antinociceptive activities of montelukast in different animal models of pain." | 3.83 | Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain. ( Alboghobeish, S; Ghorbanzadeh, B; Mansouri, MT; Sahraei, H, 2016) |
| "The mixture and the individual isolated cycloartanes significantly inhibited both phases of formalin-induced pain with percentage inhibition ranging from 13 to 78%." | 3.83 | Cycloartanes from Oxyanthus pallidus and derivatives with analgesic activities. ( Achounna, AS; Greffrath, W; Ngnokam, D; Nguelefack, TB; Piegang, BN; Tigoufack, IB; Treede, RD; Watcho, P, 2016) |
| "The EMN and allantoin antinociceptive activity were evaluated in mice using both chemical and heat-induced pain models such as acetic acid-induced writhing, formalin and tail-flick tests." | 3.83 | Antinociceptive and anti-inflammatory effects of Memora nodosa and allantoin in mice. ( Costa, EA; de Paula, JR; Florentino, IF; Galdino, PM; Lino, RC; Martins, JLR; Silva, DM; Silva, DPB; Tresvenzol, LMF, 2016) |
| " AEPM and MEPM antinociceptive effects were evaluated at the doses of 35, 75, 150 and 300mg/kg given orally, against pain induced by acetic acid, formalin, hot plate, capsaicin and glutamate." | 3.83 | Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice. ( Awouafack, MD; Kamanyi, A; Nguelefack, TB; Nkeng-Efouet, PA; Tatsinkou Bomba, FD; Wandji, BA, 2016) |
| "The role of oxytocin (OXT) in pain modulation has been suggested." | 3.83 | The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception. ( Condés-Lara, M; Godínez-Chaparro, B; González-Hernández, A; Manzano-García, A; Martínez-Lorenzana, G; Rodríguez-Jiménez, J; Rojas-Piloni, G, 2016) |
| " At same doses, SP-Ul was tested on Wistar rats on paw edema elicited by different irritants (carrageenan, dextran, bradykinin, histamine or serotonin)." | 3.83 | Analgesic and anti-inflammatory actions on bradykinin route of a polysulfated fraction from alga Ulva lactuca. ( Benevides, NM; Bezerra, MM; Chaves, HV; de Araújo, IW; de Sousa Oliveira Vanderlei, E; Maciel, GF; Pereira, KM; Quinderé, AL; Ribeiro, KA; Ribeiro, NA; Rodrigues, JA; Silva, JF, 2016) |
| " Analgesic activity using acetic acid induced writhing and formalin test in mice, anti-inflammatory activity using carrageenan induced paw oedema and acetic acid-induced vascular permeability in mice, and antipyretic activity using Brewer's yeast induced pyrexia in rats were evaluated at 100mg/kg, 200mg/kg, and 400mg/kg doses of the extract." | 3.83 | Anti-oxidant, anti-inflammatory, analgesic and antipyretic activities of grapevine leaf extract (Vitis vinifera) in mice and identification of its active constituents by LC-MS/MS analyses. ( Aouey, B; Bouaziz, M; Fetoui, H; Samet, AM; Simmonds, MSJ, 2016) |
| "6% acetic acid, indicating that fraction has an antinociceptive effect on the visceral inflammatory pain model." | 3.81 | Structure of an arabinogalactan from the edible tropical fruit tamarillo (Solanum betaceum) and its antinociceptive activity. ( Baggio, CH; Cordeiro, LM; Corso, CR; do Nascimento, GE; Iacomini, M; Werner, MF, 2015) |
| "The antinociceptive activity of EEHC was evaluated in mice using both chemical- and heat-induced pain models such as acetic acid-induced writhing, hot plate, tail immersion, formalin, and glutamate tests at 50, 100, and 200mg/kg doses." | 3.81 | Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice. ( Ferdous, A; Irin, S; Moniruzzaman, M, 2015) |
| " Then, the pharmacological activities of FJHQT extract with respect to clinical use was investigated with acetic acid-induced writhing response, formalin-induced licking response and carrageenan-induced paw edema." | 3.81 | Anti-nociceptive, anti-inflammatory and toxicological evaluation of Fang-Ji-Huang-Qi-Tang in rodents. ( Chang, CW; Lin, YC; Wu, CR, 2015) |
| " The cellular mechanism of action of formaldehyde, inducing a typically biphasic pain-related behavior in rodents is addressed in this study." | 3.81 | Formalin evokes calcium transients from the endoplasmatic reticulum. ( Fischer, MJ; Kalucka, J; Reeh, PW; Sauer, SK; Soller, KJ; Veglia, G, 2015) |
| " analgesic and anti-inflammatory activities were assessed in mice using acetic acid induced writhing, formalin induced paw edema, xylene induced ear edema assays." | 3.81 | Exploring new pharmacology and toxicological screening and safety evaluation of one widely used formulation of Nidrakar Bati from South Asia region. ( Akter, J; Akter, L; Al Mamun, A; Alam, ME; Habib, MA; Jalil, MA; Khan, MS; Syeed, SH; Zaman, A, 2015) |
| "The present study was aimed to investigate the effects of microinjection of histamine and its H1, H2 and H3 receptor antagonists, mepyramine, ranitidine and thioperamide, respectively, into the anterior cingulate cortex (ACC) on pain-related behaviors induced by formalin in rats." | 3.81 | Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats. ( Farshid, AA; Hamzeh-Gooshchi, N; Tamaddonfard, E, 2015) |
| "Antinociceptive and anti-inflammatory activities were investigated by hot plate test, acetic acid-induced abdominal writhing test and formalin test, xylene-induced ear edema test." | 3.81 | Antinociceptive and anti-inflammatory activities of Schefflera octophylla extracts. ( Chen, Y; Shen, Z; Tao, S; Xie, L; Zeng, F, 2015) |
| " The biological activities of the HERP (3, 10, and 30mg/kg) and formononetin (10mg/kg) were evaluated using the antinociceptive (acetic acid, formalin, and glutamate injections) and anti-inflammatory (carrageenan-induced hindpaw oedema and peritonitis) models in mice after oral administration." | 3.81 | Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents. ( Belo Neto, R; Berretta E Silva, AA; Cordeiro Cardoso, J; de Souza Santos, J; Divino de Araujo, E; Lima Cavendish, R; Maria Thomazzi, S; Oliveira Paixão, A; Valéria Oliveira, J; Zanardo Gomes, M, 2015) |
| " We propose the research and development of therapeutic approaches for preemptive, short- and long-term management of cancer pain using available drugs or nutraceutical agents that can suppress or neutralize lactic acid production in combination with formaldehyde scavengers." | 3.81 | Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control. ( Fang, JY; Han, B; Hoang, BX; Nimni, M; Shaw, DG, 2015) |
| "Formalin-induced acute inflammatory pain was established by intraplantar injection of 1% formalin without anesthesia or with anesthesia using the clinical anesthetics sevoflurane, propofol, or pentobarbital sodium." | 3.81 | Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex. ( Dai, RP; Li, CQ; Luo, C; Luo, W; Xu, JM; Zhang, YL; Zhou, FH, 2015) |
| " The intragastric administration of MECb (100-300 mg/kg) significantly inhibited the nociception caused by acetic acid (48 ± 2%), inflammatory phase (49 ± 3%) and paw edema (32 ± 6) caused by formalin, and MECb (100mg/kg, i." | 3.81 | Pharmacological evidence favouring the traditional use of the root bark of Condalia buxifolia Reissek in the relief of pain and inflammation in mice. ( Coelho, IS; Junqueira, SC; Maldaner, G; Morel, AF; Pizzolatti, MG; Ruani, AP; Santos, AR; Simões, RR; Venzke, D; Zanchet, EM, 2015) |
| "This study examined the short- and long-term neuroprotective and analgesic activity of honokiol (a naturally occurring lignan isolated from Magnolia) on developing brains in neonates exposed to inflammatory pain, known to cause neuronal cell death." | 3.81 | Honokiol for the Treatment of Neonatal Pain and Prevention of Consequent Neurobehavioral Disorders. ( Chen, D; Espinera, A; García, PS; Gu, X; Lee, JH; Wei, L; Woodbury, A; Yu, SP; Zhang, J, 2015) |
| " In the present study, we demonstrate prevention of BTX-A antinociceptive effect on formalin-induced inflammatory pain and partial sciatic nerve transection-induced mechanical allodynia by GABA-A antagonist bicuculline, thus suggesting association of the GABA-A receptors and antinociceptive action of BTX-A." | 3.80 | Association of antinociceptive action of botulinum toxin type A with GABA-A receptor. ( Bach-Rojecky, L; Drinovac, V; Lacković, Z, 2014) |
| " & Naudin (Ss-EtOH) in the experimental models of edema induced by carrageenan, dextran, or histamin and nociception induced by chemical stimuli, such as acetic acid, formalin, capsaicin, or glutamate." | 3.80 | Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents. ( Almeida, FR; Amaral, MP; Chaves, MH; Costa, DA; Figueiredo, KA; Júnior, FB; Oliveira, FA; Oliveira, IS; Oliveira, RC; Silva, FV, 2014) |
| " In order to evaluate the anti-inflammatory effect of these flavonoids, capsaicin-induced ear oedema was carried out." | 3.80 | Antinociceptive and anti-inflammatory effects of flavonoids PMT1 and PMT2 isolated from Piper montealegreanum Yuncker (Piperaceae) in mice. ( Alexandre-Moreira, MS; Alves, Hda S; Campesatto, EA; Cavalcante-Silva, LH; Chaves, MC; de Queiroz, AC; Dias, Tde L; Melo, GM; Santos, Mda S, 2014) |
| "After evaluation of the analgesic efficacy of dexmedetomidine in C57BL mice that were subjected to formalin-induced pain, dexmedetomidine (30 µg/kg) or saline was injected intraperitoneally (ip) 30 min before formalin (20 µL of 2% formalin in 0." | 3.80 | The antinociceptive effect of dexmedetomidine modulates spleen cell immunity in mice. ( Jang, Y; Kang, ES; Kang, JW; Song, HK; Yeom, MY, 2014) |
| "The antinociceptive activity of the extract (at the doses of 50, 100, and 200 mg/kg) was evaluated by using chemical- and heat-induced pain models such as acetic acid-induced writhing, hot plate, tail immersion, formalin, and glutamate test." | 3.80 | Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica. ( Imam, MZ; Moniruzzaman, M, 2014) |
| "Diverse proinflammatory and algesic agents activate melagatran-sensitive serine proteases that cause inflammation and pain by a PAR2-mediated mechanism." | 3.80 | Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants. ( Amadesi, S; Bogyo, M; Bunnett, NW; Carlsson, JF; Cattaruzza, F; Cottrell, GS; Kirkwood, K; Knecht, W; Lyo, V; Murphy, JE, 2014) |
| " Third, formalin-induced depression of ICSS was reversed by morphine doses that did not significantly alter ICSS in saline-treated rats, suggesting that formalin effects on ICSS can be interpreted as an example of pain-related and analgesic-reversible depression of behavior." | 3.80 | Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats. ( Carlezon, WA; Cheng, K; Leitl, MD; Negus, SS; Potter, DN; Rice, KC, 2014) |
| "The cerebrospinal fluid concentration of free neostigmine reached 5 μg/ml five hours after injection and remained constant until the end of the experiments." | 3.80 | Epidural administration of neostigmine-loaded nanofibers provides extended analgesia in rats. ( Hassanpour-Ezatti, M; Yosefifard, M, 2014) |
| "Intra-gastric administration of AGB (75, 150, and 300 mg/kg) showed a dose-dependent antinociceptive effect in intraperitoneal acetic acid (writhing), thermal nociception in CD1 mice, and subplantar formalin models, as well as anti-inflammatory effect in carrageenan- induced paw edema in Wistar rats." | 3.80 | Antinociceptive and anti-inflammatory activities of Geranium bellum and its isolated compounds. ( Altamirano-Báez, DA; Ángeles, LJ; Bautista-Ávila, M; Cariño-Cortés, R; De la O Arciniega, M; Gayosso de Lucio, JA; Ortiz, MI; Velázquez-González, C, 2014) |
| "This study aimed to investigate whether LSD1 in metastasized MRMT-1 breast cancer cells in bone marrows participated in the production of endogenous formaldehyde in bone cancer pain rats." | 3.79 | Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats. ( Cai, J; Chen, W; Li, H; Li, ZH; Liao, FF; Liu, FY; Liu, J; Luo, HJ; Luo, WH; Tang, JM; Tang, Y; Tong, ZQ; Wan, Y, 2013) |
| "In the present study, we have investigated the anti-nociceptive and anti-allodynic activity of the renin inhibitor, aliskiren, in various pain models." | 3.79 | Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models. ( Deshpande, SS; Jain, MR; Patel, RB; Pawar, VD; Prajapati, KD; Shah, GB; Sonara, BM, 2013) |
| " Opioid coadministration had a synergistic effect in the acute tonic pain (acetic acid writhing test), acute phasic pain (tail flick test) and inflammatory pain (orofacial formalin test)." | 3.79 | Systemic synergism between codeine and morphine in three pain models in mice. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Zepeda, RJ, 2013) |
| "To investigate the role of heme oxygenase and carbon monoxide (HO/CO) in the development of spontaneous pain and hyperalgesia of rats induced by formalin injection." | 3.79 | [The role of HO/CO in the spinal nociception transmission and hyperalgesia of rats induced by formalin]. ( Guo, LH; Li, HN; Li, QJ; Liu, L, 2013) |
| "The topical anti-inflammatory effects of SPRE were evaluated against acute models (croton oil-induced mouse ear edema and carrageenan-induced rat paw edema) and chronic model (complete Freund's adjuvant (CFA)-induced polyarthritis)." | 3.79 | Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid in vivo. ( Kaewnopparat, N; Mo, J; Nitiruangjaras, A; Panichayupakaranant, P; Reanmongkol, W, 2013) |
| " The antinociceptive study of DV was performed using models of acetic acid-induced writhing and formalin-induced pain in mice." | 3.79 | Bioassay-guided evaluation of Dioscorea villosa - an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach. ( Araújo, AA; Barreto, RS; de Albuquerque, RL; de Almeida, EB; Lima, AK; Lima, CM; Melo, MG; Moraes, VR; Nogueira, PC; Oliveira, DL; Oliveira, ER; Quintans-Júnior, LJ; Serafini, MR, 2013) |
| ") with EEAO before the induction of nociceptive response by formalin, capsaicin and cinnamaldehyde, thermal heat hyperalgesia (hot plate test) and mechanical allodynia (traumatic sciatic nerve injury)." | 3.79 | Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice. ( Baggio, CH; Cipriani, TR; da Silva, CF; de Souza, LM; Hamm, LA; Nascimento, AM; Nomura, EC; Rodrigues, MR; Werner, MF, 2013) |
| " The anti-inflammatory and anti-nociceptive activities of 40% ethanolic extracts of the three plants were compared using the models of xylene-induced ear edema, formalin-induced inflammation, carrageenan-induced air pouch inflammation, acetic acid-induced writhing and formalin-induced nociception." | 3.79 | Comparison of active constituents, acute toxicity, anti-nociceptive and anti-inflammatory activities of Porana sinensis Hemsl., Erycibe obtusifolia Benth. and Erycibe schmidtii Craib. ( Chen, Z; Liao, L; Wang, Z; Wu, L; Zhang, Z, 2013) |
| " Triphala recipe (4 mg/ear) significantly exhibited an inhibitory effect on the ear edema formation induced by ethyl phenylpropiolate-induced, but not on the arachidonic acid-induced ear edema in rats." | 3.79 | Evaluation of anti-inflammatory and antinociceptive activity of Triphala recipe. ( Jaijoy, K; Sireeratawong, S; Soonthornchareonnon, N, 2013) |
| "To study the effects of neonatal pain and morphine treatment on the developing brain in a neonatal rat model." | 3.79 | Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain. ( Bendix, I; Boos, V; Dührsen, L; Dzietko, M; Felderhoff-Mueser, U; Genz, K; Sifringer, M; Simons, SH; Tibboel, D, 2013) |
| " The anti-inflammatory activity was investigated using carragenin, egg-albumin induced oedema models, while acetic acid, formalin-induced paw licking and thermal-induced pain models were used to evaluate the antinociceptive property." | 3.78 | Anti-inflammatory and analgesic activities of Melanthera scandens. ( Amazu, LU; Frank, SG; Okokon, JE; Udoh, AE, 2012) |
| " The oral administration of the Chantaleela recipe reduced ulcer formation in acute gastric ulcer models (EtOH/HCl-, indomethacin-, and stress-induced gastric lesions)." | 3.78 | Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe. ( Jaijoy, K; Khonsung, P; Nanna, U; Piyabhan, P; Sireeratawong, S; Soonthornchareonnon, N, 2012) |
| " We investigated the effects of the fatty acid amide hydrolase (FAAH) inhibitor URB597, which inhibits the catabolism of the endocannabinoid anandamide and related N-acylethanolamines, on expression of FCA and fear and pain related behaviour per se in rats." | 3.78 | Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase. ( Butler, RK; Chapman, V; Doyle, KM; Finn, DP; Ford, GK; Hogan, M; Kelly, JP; Kendall, DA; Roche, M, 2012) |
| "Spinal hydrogen peroxide is specifically and largely responsible for formalin-induced pain, and DAAO inhibitors produce analgesia by blocking spinal hydrogen peroxide production rather than interacting with spinal D-serine." | 3.78 | D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. ( Gong, N; Lu, JM; Wang, YC; Wang, YX, 2012) |
| "We investigated the influence of the N-methyl-D-aspartate (NMDA) receptor antagonist memantine on pain pathways involving trigeminocervical complex (TCC) using a formalin injection model." | 3.78 | Influence of memantine on nociceptive responses of the trigeminocervical complex after formalin injection. ( Park, GE; Park, JW; Shin, HE; Suh, GI, 2012) |
| "Benzaldehyde semicarbazone (BS) inhibited zymosan writhing response, carrageenan paw edema and both phases of formaldehyde nociceptive response." | 3.78 | Influence of susceptibility to hydrolysis and hydrophobicity of arylsemicarbazones on their anti-nociceptive and anti-inflammatory activities. ( Bastos, LF; Beraldo, H; Coelho, MM; Costa, FB; Ferreira, WC; Lessa, JA; Rocha, WR; Vieira, RP, 2012) |
| "Tolerance to morphine analgesia following repeated administration disturbs the continuation of opioid therapy for severe pain." | 3.78 | Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms. ( Fukazawa, Y; Iwai, S; Kiguchi, N; Kishioka, S; Kobayashi, Y; Saika, F; Ueno, K; Yamamoto, C, 2012) |
| "The extract was evaluated for antinociceptive activity using chemical- and heat-induced pain models such as acetic acid-induced writhing, hot plate, tail immersion and formalin test." | 3.78 | Antinociceptive activity of methanol extract of flowers of Impatiens balsamina. ( Akter, S; Imam, MZ; Nahar, N; Rana, MS, 2012) |
| " In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model." | 3.78 | Antinociceptive effects of intrathecal landiolol injection in a rat formalin pain model. ( Itano, Y; Kaku, R; Kanzaki, H; Matsuoka, Y; Mizobuchi, S; Morita, K; Nishie, H; Obata, N; Ouchida, M; Taniguchi, A; Tomotsuka, N, 2012) |
| " EO(MeOH) was evaluated for its analgesic activity in acetic acid-induced writhing response and formalin test, and anti-inflammatory effect was examined by λ-carrageenan-induced paw edema assay." | 3.78 | Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice. ( Chang, YS; Ho, YL; Lai, SC; Liao, CR; Peng, WH, 2012) |
| "Endothelin-1 (ET-1) has been suggested to be involved in different types of pain due to its neuromodulatory nature." | 3.78 | Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection. ( Chen, AY; Chen, SM; Cheung, CW; Chung, SK; Hung, VK; Tai, LW, 2012) |
| "Effects of stress during different periods of ontogeny, namely, the prenatal, prepubertal, or their combination (prenatal+prepubertal), on the indices of psychoemotional and tonic pain-related behaviors, as well as corticosterone reactivity after pain behavior were investigated in adult 90-day-old female Wistar rats." | 3.78 | [Long-term effects of stress in critical periods of development on reactivity of adult female rats]. ( Bagaeva, TR; Butkevich, IP; Mikhaĭlenko, VA; Vershinina, EA, 2012) |
| "In northeastern Brazil, Dinoponera (Ponerinae) ants macerate are used to treat ear ache and its sting, rheumatism, and back pain." | 3.78 | Venom's antinociceptive property in the primitive ant Dinoponera quadriceps. ( Assreuy, AM; do Vale, JF; Pereira, MG; Ponte, EL; Quinet, Y; Sousa, PL; Torres, AF, 2012) |
| " The anti-nociceptive activities of MPP were measured using various experimental pain models including thermal nociception methods such as the tail immersion test and the hot plate test as well as chemical nociception methods like acetic acid-induced writhing test and formalin test." | 3.78 | Anti-inflammatory and anti-nociceptive properties of Prunus padus. ( Cha, DS; Choi, JH; Jeon, H, 2012) |
| "The results showed that the ethanolic extract of the Bougainvillea xbuttiana has significant anti-inflammatory and antinociceptive activities, by inhibition of nociception induced by acetic acid and paw oedema." | 3.78 | Anti-inflammatory and antinociceptive activities of the ethanolic extract of Bougainvillea xbuttiana. ( Alvarez Perez Gil, AL; Barbosa Navarro, L; Patipo Vera, M; Petricevich, VL, 2012) |
| " We have investigated the behavioural effects of carvacrol in animal models of pain, such as acetic acid-induced abdominal constriction, formalin and hot-plate tests in mice." | 3.78 | Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice. ( Cavalcante Melo, FH; Citó, Mdo C; de Sousa, DP; de Sousa, FC; de Vasconcelos, SM; Fernandes, ML; Rios, ER; Rocha, NF, 2012) |
| "The antinociceptive and antiinflammatory activities of MEA were evaluated using the writhing, formalin, and tail-flick tests, carrageenan-induced paw edema and arachidonic acid-induced ear edema." | 3.77 | Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1β inhibition. ( Barros, TA; Lucchese, AM; Nogueira, TM; Nonato, FR; Oliveira, CE; Santos, RR; Soares, MB; Villarreal, CF, 2011) |
| " While the analgesic activity was examined against thermally and chemically induced nociceptive pain in mice, using the acetic acid and hot-plate test methods." | 3.77 | Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha. ( Duan, JA; Hua, YQ; Qian, DW; Su, S; Tang, YP; Wang, T; Yu, L; Zhou, W, 2011) |
| " The antinociceptive effects of LEJ were assessed using experimental models of pain, including thermal nociception methods, such as the tail immersion test and the hotplate test, and chemical nociception induced by intraperitoneal acetic acid and subplantar formalin in mice." | 3.77 | Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica. ( Cha, DS; Eun, JS; Jeon, H, 2011) |
| "To evaluate the antinociceptive effect of Emilia sonchifolia hydroethanolic extract (EsHE) administered by oral route, peripheral (acetic acid-induced abdominal writhing and formalin), spinal (tail flick) and supra-spinal (hot plate) behavioral models of acute pain were used." | 3.77 | Antinociceptive effect of extract of Emilia sonchifolia in mice. ( Couto, VM; Dias, DF; Dos Santos, MH; Giusti-Paiva, A; Nascimento, CG; Soncini, R; Vilela, FC, 2011) |
| " Effects of intrathecal glutamate transporter activator (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline and inhibitors (DL-threo-β-benzyloxyaspartate [TBOA], dihydrokainate, and DL-threo-β-hydroxyaspartate), or TBOA plus group III metabotropic glutamate receptor antagonist (RS)-α-methylserine-O-phosphate, on formalin- and CFA-induced inflammatory pain were examined." | 3.77 | Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant. ( Guan, X; Lu, W; Petralia, RS; Rothstein, JD; Tao, YX; Yaster, M, 2011) |
| " Several animal models of persistent inflammatory and neuropathic pain (tail-flick test, hot plate test, acetic acid-induced writhing test, formalin-induced paw licking, carrageenan-induced paw edema) were used to test analgesic functions of recombinant anntoxin (r-anntoxin)." | 3.77 | Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin. ( Dong, L; Lai, R; Liu, H; Liu, R; Wei, L; Yang, H; You, D; Zhao, T, 2011) |
| "To investigate the expression of protein kinase C (PKC) in the spinal dorsal horn of rats with formalin-induced pain and the effect of intrathecal ketamine on PKC expression." | 3.77 | [Effect of intrathecal ketamine injection on protein kinase C expression in the spinal dorsal horn of rats with formalin-induced pain]. ( GUO, QL; WANG, E; YAN, JQ; YANG, Y; ZOU, WY, 2011) |
| " All extracts were evaluated for (1) topical administration against both arachidonic acid and 12-deoxyphorbol-13-decanoate (TPA)-induced inflammation in mice and (2) per-os administration against inflammation by λ-carrageenan-induced paw oedema in guinea-pigs and (3) topical analgesia in tail flick and formalin models and per-os writhing test in mice." | 3.77 | Chemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae. ( Backhouse, N; Christen, P; Correa, O; Costa, E; Cretton, S; Delporte, C; Miranda, H; Muñoz, O; Torres, V, 2011) |
| "The aim of the present study was to investigate the preemptive analgesic effects of intraperitoneally administrated midazolam and diclofenac, before acute and inflammatory induced pain in rat model." | 3.77 | Preemptive analgesic effects of midazolam and diclofenac in rat model. ( Hasani, A; Jakupi, M; Soljakova, M; Ustalar-Ozgen, S, 2011) |
| "Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception." | 3.77 | Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats. ( Ghasri, S; Hamzely, A; Khoshkholgh Sima, B; Mobarakeh, JI; Nezhad, RM; Nunoki, K; Rahimi, AA; Takahashi, K; Torkaman-Boutorabi, A; Yanai, K, 2011) |
| "This study investigated the analgesic effects of taraxeren-3-one, which is an ingredient from Diospyros maritima (DM), using the models of acetic acid-induced writhing response and the formalin test, and its anti-inflammatory effects using the model of λ-carrageenan (Carr)-induced paw edema." | 3.77 | Analgesic effects and mechanisms of anti-inflammation of taraxeren-3-one from Diospyros maritima in mice. ( Chang, CI; Chang, TN; Chang, YS; Deng, JS; Huang, GJ; Huang, SS; Kuo, YH; Yang, HL, 2011) |
| "Kirenol has demonstrated its significant potential to be further investigated for its discovery as a new lead compound for management of topical pain and inflammation, although further pharmacological research is necessary to fully understand its mechanism of action." | 3.77 | Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis. ( Cai, YL; Shang, XM; Wang, JP; Wu, YX; Xiong, CM; Xu, HX; Ye, YJ; Zhou, YM, 2011) |
| " Treatment of male ICR mice with ETL significantly inhibited the numbers of acetic acid-induced writhing response and the formalin-induced pain in the late phase." | 3.77 | Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola. ( Chi, CS; Deng, JS; Huang, GJ; Huang, SS; Lin, TH; Shie, PH, 2011) |
| "The antinociceptive effect of MCO was evaluated using several experimental pain models, including thermal nociception methods, such as the tail immersion and the hotplate tests, as well as chemical nociception induced by intraperitoneal acetic acid and subplantar formalin administration in mice." | 3.77 | Antinociceptive and hypnotic properties of Celastrus orbiculatus. ( Cha, DS; Jeon, H; Park, HJ, 2011) |
| "Salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their complexes [Zn(LASSBio-466)H(2)O](2) (1) and [Zn(HLASSBio-1064)Cl](2) (2) were evaluated in animal models of peripheral and central nociception, and acute inflammation." | 3.77 | Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes. ( Alexandre-Moreira, MS; Alves, MA; Barreiro, EJ; Beraldo, H; Castellano, EE; Júnior, WB; Lima, LM; Parrilha, GL; Perez-Rebolledo, A; Piro, OE, 2011) |
| " In an inflammatory pain model, Compound 5 suppressed the capsaicin-induced flinching behavior in a dose-dependent manner." | 3.77 | Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia. ( Akasaka, Y; Hatta, A; Inoue, H; Sakai, A; Suzuki, H; Takasu, K; Tsukahara, M, 2011) |
| " The anti- oedema effect was compared with indomethacin." | 3.76 | Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum. ( Antonisamy, P; Ignacimuthu, S, 2010) |
| " The present study was designed to investigate neuronal responses to formalin-induced 2-phase pain and morphine-induced antinociception in the nucleus cuneiformis (CnF) that is part of the descending pain modulatory system." | 3.76 | Formalin-induced differential activation of nucleus cuneiformis neurons in the rat: an electrophysiological study. ( Haghparast, A; Khani, A; Lashgari, R; Motamedi, F; Naderi, N, 2010) |
| " Our results showed that the iridoid glycosides extract could decrease acetic-acid-induced writhings times and formalin-induced lickings times, inhibit carrageenan-induced hind paw edema and xylene-induced ear swelling, and suppress peritoneal capillary permeability and leukocyte infiltration also induced by acetic acid in mice." | 3.76 | Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo. ( Fan, P; Jia, Z; Li, M; Shang, X; Wei, L; Ying, Q; Zhang, R, 2010) |
| "This study examined the analgesic and anti-inflammatory actions of cis-mulberroside A isolated from Ramulus mori in several models of inflammatory pain in mice." | 3.76 | Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori. ( Shi, L; Zhang, Z, 2010) |
| "The effect of morphine is often studied in the absence of pain, and it remains poorly understood if and how noxious stimulation may change the activity state of descending pain-modulatory pathways and their response to morphine." | 3.76 | Visualizing acute pain-morphine interaction in descending monoamine nuclei with Fos. ( Bajic, D; Commons, KG, 2010) |
| "Milnacipran and duloxetine, serotonin/noradrenalin reuptake inhibitors, and pregabalin, a alpha(2)-delta(1) Ca(2+) channel blocker, are efficacious against fibromyalgia, a condition characterized by diffuse chronic pain and associated with stress." | 3.76 | Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats. ( Aliaga, M; Bardin, L; Depoortère, R; Gregoire, S; Ladure, P; Malfetes, N; Newman-Tancredi, A; Vitton, O, 2010) |
| " Experiments were conducted on Swiss mice using the acetic acid-induced writhing test, the hot plate test, the formalin-induced pain test and zymosan A-induced peritonitis test." | 3.76 | The antinociceptive and anti-inflammatory activities of Piptadenia stipulacea Benth. (Fabaceae). ( Agra, Mde F; Alexandre-Moreira, MS; da Matta, CB; da Silva, DJ; de Aquino, AB; de Araújo-Júnior, JX; de Lira, DP; de Queiroz, AC; de Souza, ET; Dias, Tde L; Filho, JM; Mella, EA; Santos, BV; Silva, LH, 2010) |
| "Z-360, a novel cholecystokinin(2) (CCK(2)) receptor antagonist, has been developed as a therapeutic drug for pancreatic cancer and showed pain relief action in phase Ib/IIa clinical trial." | 3.76 | Pharmacological evaluation of analgesic effects of the cholecystokinin2 receptor antagonist Z-360 in mouse models of formalin- and cancer-induced pain. ( Eta, R; Hamano, H; Hori, Y; Horii, T; Kawabata, Y; Kuraishi, Y; Orikawa, Y; Ozaki, T; Seto, K; Takei, M; Yoshii, K; Yoshinaga, K, 2010) |
| " The blueberry extract produced a significant decrease in constrictions induced by acetic acid and caused graded inhibition of the second phase of formalin-induced pain." | 3.76 | Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models. ( Barros, DM; de Castro, MR; de Souza, MM; Dickel, OE; Guterres, L; Henriques, AT; Ramirez, MR, 2010) |
| " The objective of this study was to investigate the antinociceptive effect of the ethanolic extract from this species' stem bark (EtOH), its fractions of partition (hexane-HEX, ethyl acetate-AcOEt, aqueous-AQ) and lupeol (a triterpene obtained from HEX) in models of acute pain." | 3.76 | Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents. ( Almeida, FR; Chaves, MH; Costa, DA; Figueiredo, KA; Lopes, LS; Marques, RB; Pereira, SS, 2010) |
| "Isovaline reduced responses in mouse pain models without producing acute toxicity, possibly by enhancing receptor modulation of nociceptive information." | 3.76 | Analgesic properties of the novel amino acid, isovaline. ( Chung, CC; MacLeod, BA; Puil, E; Ries, CR; Schwarz, SK; Wang, JT, 2010) |
| " Accumulated evidence shows that endogenous formaldehyde concentrations are elevated in the blood or urine of patients with breast, prostate or bladder cancer." | 3.76 | Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain. ( Duan, B; Han, Y; Li, H; Liu, F; Luo, H; Luo, W; Maoying, Q; Tan, H; Tong, Z; Wan, Y; Wang, J; Wang, Y; Xu, T; Yang, F; Zhao, H, 2010) |
| " Using the animal pain models by applying Acetic Acid Writhing Test and Formalin Test, the combination of SF and OMT showed significant analgesic effect in dose-dependent manner." | 3.76 | The analgesic effect and mechanism of the combination of sodium ferulate and oxymatrine. ( Chen, F; Gao, Y; Liu, H; Liu, Z; Sun, Y; Xu, M, 2010) |
| "A profound tachyphylaxis of the acute nocifensive flinching (pain) response to subcutaneous injection of endothelin-1 (ET-1) into the hind paw footpad is shown by the reduced response to a second injection." | 3.76 | Remarkably long-lasting tachyphylaxis of pain responses to ET-1: evidence against central nervous system involvement. ( Khodorova, A; Strichartz, GR, 2010) |
| "These results indicate that KOR plays an important role in the inhibition of repeated morphine-induced cPKC up-regulation under chronic pain condition." | 3.76 | Involvement of kappa opioid receptors in the formalin-induced inhibition of analgesic tolerance to morphine via suppression of conventional protein kinase C activation. ( Fujita-Hamabe, W; Harada, S; Nagae, R; Nakamoto, K; Nawa, A; Tokuyama, S, 2010) |
| "The inhibitory transmitters GABA and glycine play an important role in modulating pain transmission, both in normal and in pathological situations." | 3.76 | Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models. ( Duraku, LS; Holstege, JC; Hossaini, M; Jongen, JLM; Saraç, Ç, 2010) |
| "We examined the antioxidant properties in vitro and the antinociceptive effect of carvacrol (CARV) in several models of pain in mice." | 3.76 | Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrol. ( Antoniolli, AR; Araújo, AA; Bonjardim, LR; Cavalcanti, SC; Gelain, DP; Guimarães, AG; Melo, MS; Moreira, JC; Oliveira, GF; Quintans-Júnior, LJ; Rocha, RF; Santos, JP; Silva, FA, 2010) |
| " The purpose of this study on male rats was to determine the effects of a single injection of morphine (5 mg/Kg) on persistent pain (formalin test) and the single or combined effects on p450-aromatase and 5-alpha reductase type 1 mRNA expression in the brain, liver and testis." | 3.76 | Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats. ( Aloisi, AM; Anzini, M; Cappelli, A; Ceccarelli, I; Danielli, B; Fiorenzani, P; Giordano, A; Maddalena, M; Rossi, A; Rovini, M; Sorda, G; Tomei, V, 2010) |
| " In the present study, we focus on the influence of the maternal corticosterone milieu and its role in the effects of stress during pregnancy on formalin-induced pain and the corticosterone response to it in male and female offspring of different ages." | 3.75 | Effects of maternal corticosterone and stress on behavioral and hormonal indices of formalin pain in male and female offspring of different ages. ( Aloisi, AM; Bagaeva, T; Butkevich, I; Mikhailenko, V; Otellin, V; Semionov, P, 2009) |
| "The purpose of this study was to assess the possible antinociceptive effect of the acid sensing ion channels (ASICs) inhibitors amiloride and benzamil after local peripheral administration in three models of inflammatory pain in rats." | 3.75 | Acid increases inflammatory pain in rats: effect of local peripheral ASICs inhibitors. ( García-López, BE; Granados-Soto, V; Herrejon-Abreu, EB; López-Santillán, FJ; Murbartián, J; Rocha-González, HI, 2009) |
| " Carrageenan oedema, cotton pellet granuloma and formaldehyde arthritis models were used to quantify the anti-inflammatory activities while the brewer's yeast was used for inducing pyrexia." | 3.75 | Studies on the analgesic, anti-inflammatory and antipyretic effects of Parquetina nigrescens leaf extract. ( Nafiu, AB; Owoyele, BV; Oyewole, IA; Oyewole, LA; Soladoye, AO, 2009) |
| "Our data suggest that activation of spinal or dorsal root ganglion HCN channels or both is not involved in formalin-induced pain, and intrathecal gabapentin does not act as an HCN channel activator to achieve its antinociceptive effect in the formalin test." | 3.75 | Intrathecal gabapentin does not act as a hyperpolarization-activated cyclic nucleotide-gated channel activator in the rat formalin test. ( Chen, CC; Cheng, JK; Huang, YJ; Lin, CF; Lin, CS; Tsaur, ML, 2009) |
| ") 1 h prior to testing, produced dose-dependent inhibition of acetic acid-induced visceral pain, with ID50 value of 241." | 3.75 | Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice. ( Calixto, JB; Chaves, J; Ferreira, VM; Guginski, G; Luiz, AP; Martins, DF; Massaro, M; Mattos, RW; Santos, AR; Silva, MD; Silveira, D, 2009) |
| "The GABA amides of the antidepressants nortriptyline and fluoxetine, 1 and 2, were compared to their respective parent compounds in rodent models of pain." | 3.75 | Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity. ( Aharoni, A; Geffen, Y; Gil-Ad, I; Halbfinger, E; Nisemblat, Y; Nudelman, A; Rephaeli, A; Tarasenko, I; Tarasenko, N; Weizman, A, 2009) |
| "6% of 10 ml) induced pain and the effects were also compared to aspirin, morphine and naloxone while formalin induced pain (0." | 3.75 | Antinociceptive activity of Amaranthus spinosus in experimental animals. ( Amresh, G; Rao, CV; Singh, S; Zeashan, H, 2009) |
| " Formalin-induced pain-related behaviour and c-Fos expression in the trigeminal caudal nucleus (Vc) with/without systemic preadministration of a gamma-aminobutyric acid (GABA) type A receptor antagonist, bicuculline (2 mg/kg, i." | 3.75 | Effects of systemic bicuculline or morphine on formalin-evoked pain-related behaviour and c-Fos expression in trigeminal nuclei after formalin injection into the lip or tongue in rats. ( Abe, T; Kobayashi, M; Satoh, F; Sugiyo, S; Takemura, M; Uehashi, D; Yonehara, N, 2009) |
| "The aim of this study was to establish the effect of lidocaine, a local anesthetic, on pain and itch using formalin-induced nociception and kappa opioid antagonist-induced scratching models in mice." | 3.75 | Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5'-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence. ( Cowan, A; Dun, NJ; Inan, S, 2009) |
| "The present study examined the antinociceptive effects of (O-methyl) N-benzoyl-tyramine (riparin I, ripI) isolated from the unripe fruit of Aniba riparia in chemical and thermal behavioral models of pain, such as acetic acid-induced abdominal writhing, formalin, and hot-plate tests in mice." | 3.75 | Antinociceptive effects of (O-methyl)-N-benzoyl tyramine (riparin I) from Aniba riparia (Nees) Mez (Lauraceae) in mice. ( Amaral, JF; Araújo, FL; Barbosa-Filho, JM; de Sousa, FC; Gutierrez, SJ; Leite, CP; Melo, CT; Moura, BA; Rocha, NF; Vasconcelos, SM; Viana, GS, 2009) |
| "Central neurotensin (NT) administration results in a naloxone-insensitive antinociceptive response in animal models of acute and persistent pain." | 3.75 | Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity. ( Baudisson, S; Beaudet, N; Belleville, K; Dansereau, MA; Ezzoubaa, F; Martinez, J; Richelson, E; Roussy, G; Sarret, P, 2009) |
| "This study assesses the effects of peripheral or intrathecal pre-treatment or post-treatment with micro, delta, kappa and nociceptin/orphanin FQ (NOP) opioid receptor agonists (morphine, U-50488 [trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride], DADLE [D-Ala2-Leu5-enkephalin] and nociceptin, respectively) on formalin-induced secondary mechanical allodynia and hyperalgesia in rats." | 3.75 | Role of opioid receptors in the reduction of formalin-induced secondary allodynia and hyperalgesia in rats. ( Ambriz-Tututi, M; Araiza-Saldaña, CI; Caram-Salas, NL; Castañeda-Corral, G; Cruz, SL; Granados-Soto, V; Rocha-González, HI, 2009) |
| " In the present study, we used the conditioned place aversion (CPA) paradigm to investigate the role of corticosterone (CORT) in the negative affective component of chemical somatic pain induced by intraplantar injection of formalin into male adult Long-Evan rats." | 3.75 | Roles of corticosterone in formalin-induced conditioned place aversion in rats. ( Chai, SC; Huang, AC; Wang, CC; Wang, HC; Wang, YC; Wu, YS, 2009) |
| " Acetic acid-induced writhing response and formalin-induced pain were examined the analgesics effects of WET." | 3.75 | Analgesic and anti-inflammatory activities of a water extract of Trachelospermum jasminoides (Apocynaceae). ( Chen, JS; Cheng, HC; Chien, YC; Chou, PY; Huang, GJ; Huang, MH; Sheu, MJ; Wang, BS; Wu, CH, 2009) |
| " The pharmacological assays used were the writhing and the hot plate tests, the formalin-induced pain, the capsaicin-induced ear edema and the carrageenan-induced peritonitis." | 3.75 | The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa. ( Alexandre-Moreira, MS; Barbosa-Filho, JM; Chaves, MC; da Silva, DJ; de Aquino, AB; de Araújo-Júnior, JX; de Athayde-Filho, PF; de Lira, DP; de Miranda, GE; de Queiroz, AC; de Souza, ET; Lorenzo, VP; Mella, EA; Santos, BV, 2009) |
| "Tissue damage and its downstream consequences are experimentally assayed by formaldehyde application, which indiscriminately modifies proteins and is presumed to cause pain through broadly acting mechanisms." | 3.74 | An ion channel essential for sensing chemical damage. ( Corey, DP; Cravatt, B; Dubin, AE; Hwang, S; Kwan, KY; Macpherson, LJ; Patapoutian, A; Petrus, MJ; Xiao, B, 2007) |
| "To evaluate the effect of intrathecal pumping tramadol on cell-mediated immunity in rats with formalin inflammatory pain." | 3.74 | [Effect of intrathecal pumping tramadol on the immune function in rats with formalin pain]. ( Cai, J; Guo, QL; Wang, E; Wang, YC; Xu, DM; Yang, HW; Zou, WY, 2008) |
| "We evaluated the effects of zonisamide on inflammatory and neuropathic pain using the mouse formalin test and streptozotocin (STZ)-induced diabetic mice with a reduced withdrawal threshold to mechanical stimuli, respectively." | 3.74 | Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy. ( Murakami, T; Ono, H; Tanabe, M, 2008) |
| ") dose-dependently inhibited nociceptive behavior in the acetic acid-induced pain test." | 3.74 | Quercetin: further investigation of its antinociceptive properties and mechanisms of action. ( de Souza, MM; Filho, AW; Filho, VC; Olinger, L, 2008) |
| " In the present study, morphine (a low dose) was combined with S(+)- and R(-)-norketamine (sub-antinociceptive doses) and characterized utilizing rodent models of pain including: thermal nociception (the tail-flick test), peripheral neuropathy (chronic constriction nerve injury) and tonic inflammatory pain (the formalin test)." | 3.74 | Interaction between morphine and norketamine enantiomers in rodent models of nociception. ( Crooks, PA; Holtman, JR; Johnson-Hardy, J; Wala, EP, 2008) |
| "Amygdalin is a plant glucoside isolated from the stones of rosaceous fruits, such as apricots, peaches, almond, cherries, and plums." | 3.74 | Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats. ( Hahm, DH; Hwang, HJ; Kim, CJ; Kim, P; Lee, HJ; Shim, I; Yang, Y; Yin, CS, 2008) |
| " The glucan was tested for its effects on the acetic acid-induced writhing reaction in mice, a typical model for quantifying inflammatory pain." | 3.74 | Anti-inflammatory and analgesic properties in a rodent model of a (1-->3),(1-->6)-linked beta-glucan isolated from Pleurotus pulmonarius. ( Baggio, CH; Carbonero, ER; Freitas, CS; Gorin, PA; Iacomini, M; Marcon, R; Olsen, LM; Santos, AR; Smiderle, FR, 2008) |
| "Painful reaction of rats to intraperitoneal injections of L-arginine, Nw-nitro-L-arginine, and agmatine was studied on the model of formalin-induced inflammation." | 3.74 | Effects of NO-modulating agents on the development of acute painful reaction in rats. ( Dyuizen, IV; Lamash, NE, 2008) |
| " For evaluation of inflammation carrageenan-, histamine- and serotonin-induced paw edema served as acute models and formaldehyde-induced arthritis served as a chronic model in rats." | 3.74 | Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract. ( Gunnam, KK; Parle, M; Vasudevan, M, 2007) |
| "Using a conditioned place paradigm, we examined the involvement of the bed nucleus of the stria terminalis (BST) in the negative affective component of visceral and somatic pain induced by intraperitoneal acetic acid and intraplantar formalin injections, respectively, in rats." | 3.74 | Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats. ( Deyama, S; Kaneko, S; Minami, M; Nakagawa, T; Uehara, T, 2007) |
| "In this study, the effect of (S)-3,4-dicarboxyphenylglycine (DCPG), a selective mGlu8 receptor agonist, has been investigated in inflammatory and neuropathic pain models in order to elucidate the role of mGlu8 receptor in modulating pain perception." | 3.74 | Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice. ( de Novellis, V; Maione, S; Marabese, I; Palazzo, E; Rossi, F; Scafuro, MA; Vita, D, 2007) |
| "The antiinflammatory effect of the aqueous leaf extract of Byrsocarpus coccineus was evaluated using the carrageenan and egg albumin induced rat paw edema, xylene induced mouse ear edema and formaldehyde induced arthritis inflammation tests." | 3.74 | Antiinflammatory activity of the aqueous leaf extract of Byrsocarpus coccineus. ( Adeyemi, OO; Akindele, AJ, 2007) |
| " Antiinflammatory effects were evaluated using carrageenan- and formalin-induced paw edema, and arachidonic acid-induced ear edema in mice." | 3.74 | Antinociceptive and antiinflammatory activities of pine (Pinus densiflora) pollen extract. ( Choi, EM, 2007) |
| " Here we report a synergistic antinociceptive interaction between the endogenous cannabinoid receptor agonist anandamide and the synthetic peroxisome proliferator-activated receptor-alpha (PPAR-alpha) agonist 2-(4-(2-(1-Cyclohexanebutyl)-3-cyclohexylureido)ethyl)phenylthio)-2-methylpropionic acid (GW7647) in a model of acute chemical-induced pain." | 3.74 | Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. ( Calignano, A; D'Agostino, G; La Rana, G; LoVerme, J; Piomelli, D; Russo, R; Sasso, O, 2007) |
| "In the current study we compared the potency of the selective metabotropic glutamate receptor (mGluR1) antagonist A-841720 (7-Azepan-1-yl-4-dimethylamino-7H-9-thia-1,5,7-triaza-fluoren-8-one) in rodent models of pain with its effects in models of learning and memory, to obtain information regarding the therapeutic window of this compound." | 3.74 | Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. ( Barberi, C; Belozertseva, I; Danysz, W; Gravius, A; Malyshkin, A; Morè, L; Pietraszek, M; Schaefer, D; Schmidt, WJ; Shekunova, E, 2007) |
| "In the present study, we have investigated the analgesic effect of the aqueous extract of the root of Glycine tomentella (AGT) using models of acetic acid-induced writhing response and formalin test, the anti-inflammatory effect of AGT using model of lambda-carrageenan-induced paw edema." | 3.74 | Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice. ( Huang, HW; Hung, YC; Ko, YZ; Lin, YC; Lu, TC; Peng, WH, 2007) |
| "One of the possible sites of action of the analgesic effect of morphine is the Nucleus Raphe Magnus, as morphine injected into this structure induces analgesia in transient pain models." | 3.74 | Analgesia induced by morphine microinjected into the nucleus raphe magnus: effects on tonic pain. ( Dallel, R; Dualé, C; Sierralta, F, 2007) |
| " We investigated the effect induced by minocycline and doxycycline in models of nociceptive and inflammatory pain, edema, fever, cell migration and formation of fibrovascular tissue, as these effects have not been fully investigated." | 3.74 | Characterization of the antinociceptive and anti-inflammatory activities of doxycycline and minocycline in different experimental models. ( Bastos, LF; Coelho, MM; Merlo, LA; Rocha, LT, 2007) |
| "This study examined the role of kappa opioid receptors (KOR) in the mechanism underlying tolerance to the analgesic effects of morphine induced by chronic pain." | 3.74 | Involvement of kappa opioid receptors in formalin-induced inhibition of analgesic tolerance to morphine in mice. ( Hamabe, W; Mashida, E; Nagae, R; Tokuyama, S, 2007) |
| "Calcitonin gene-related peptide (CGRP) and substance P (SP) play an important role in the development of pain and hyperalgesia." | 3.74 | Role of calcitonin gene-related peptide and substance P in different models of pain. ( Buscone, S; Di Bella, P; Greco, R; Nappi, G; Sandrini, G; Tassorelli, C, 2008) |
| "The present study investigated the hypothesis that hydrogen sulfide (H2S) is pro-nociceptive in the formalin model of persistent inflammatory pain in the adult rat." | 3.74 | A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain. ( Cheng, Y; Khanna, S; Lee, AT; Li, L; Moore, PK; Shah, JJ, 2008) |
| "The dose-response relation of S-methylisothiourea, rofecoxib, mefenamic acid, and their combination was studied in the late phase of formalin-induced pain in mice over the time spent in licking the hindpaw after formalin injection." | 3.74 | The interaction between inhibitors of nitric oxide synthase and cyclooxygenase in formalin-induced pain in mice: an isobolographic study. ( Bhat, AS; Krishna, V; Kumar, D; Prakash, VR; Tandan, SK, 2008) |
| " Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously)." | 3.74 | Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| " In the present study, we examined the antinociceptive effect of nicotine administered supra-spinally on acetic acid-induced visceral pain induction (writhing test), and found that the antinociceptive effect of nicotine was abolished by mu-, delta-, and kappa-opioid receptor antagonist administered i." | 3.74 | The effect of formalin pretreatment on nicotine-induced antinociceptive effect: the role of mu-opioid receptor in the hippocampus. ( Choi, SM; Jung, JS; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Suh, HW, 2008) |
| "Recent clinical studies have demonstrated that when morphine is used to control pain in cancer patients, psychological dependence is not a major concern." | 3.73 | Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state. ( Ise, Y; Kishimoto, Y; Misawa, K; Narita, M; Suzuki, T; Yajima, Y, 2005) |
| "Intrathecally administered edaravone, a free radical scavenger, had analgesic effects on inflammatory-induced acute and facilitated pain but not on acute thermal pain, without any behavioural side-effects." | 3.73 | Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats. ( Nishiyama, T; Ogawa, M, 2005) |
| "Pretreatment with intravenous ketamine inhibits inflammatory pain behavior and FLI expression following a formalin injection in rats, suggesting that pretreatment of ketamine plays an important role in preemptive analgesia." | 3.73 | Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity. ( Lee, IH; Lee, IO, 2005) |
| "To evaluate the immunological function in rats with formalin inflammatory pain through intrathecal pumping different dosages of morphine." | 3.73 | [Effect of intrathecal pumping morphine on immunological function in rats with formalin pain]. ( Cai, J; Guo, QL; Wang, E; Zou, WY, 2005) |
| "We studied the effects of the high-efficacy 5-hydroxytryptamine1A (5-HT1A) receptor agonist, F 13640 on both formalin-induced spinal cord c-Fos protein expression and pain behaviours in the rat." | 3.73 | Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: a c-Fos study. ( Aliaga, M; Besson, JM; Buritova, J; Colpaert, F; Larrue, S, 2005) |
| " In order to determine if the endogenous opioid system is involved in this antinociception, naloxone was administered just prior to the injection of a selective P2X3/P2X2/3 receptor antagonist, A-317491, in rat models of neuropathic, chemogenic, and inflammatory pain." | 3.73 | Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain. ( Bianchi, B; Faltynek, CR; Honore, P; Jarvis, MF; McDonald, HA; McGaraughty, S; Mikusa, J; Wismer, CT; Zhu, CZ, 2005) |
| "Formalin-induced pain is reduced in sigma-1 (sigma1) receptor knockout mice; therefore, we hypothesized that haloperidol and its metabolites I and II, which have affinity for sigma1 receptors, may modulate formalin-induced pain." | 3.73 | Antinociceptive effects of haloperidol and its metabolites in the formalin test in mice. ( Baeyens, JM; Cendán, CM; Portillo-Salido, E; Pujalte, JM, 2005) |
| "Zaprinast is a phosphodiesterase inhibitor that is active in various models of pain when administered locally." | 3.73 | Lack of the nitric oxide-cyclic GMP-potassium channel pathway for the antinociceptive effect of intrathecal zaprinast in a rat formalin test. ( Bae, HB; Choi, JI; Chung, SS; Chung, ST; Jeong, CY; Jeong, SW; Kim, CM; Kim, SJ; Yoo, KY; Yoon, MH, 2005) |
| " To study the participation of histamine in pain perception, histidine decarboxylase knockout mice were examined for pain threshold by means of three different kinds of noxious stimuli: thermal nociception (hot-plate, tail-flick, and paw-withdrawal), mechanical nociception (tail-pressure), and chemical nociception (formalin test and capsaicin test)." | 3.73 | Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice. ( Kato, M; Kuramasu, A; Mobarakeh, JI; Orito, T; Sakurada, S; Sakurai, E; Yanai, K; Yoshida, A, 2005) |
| "To reveal peripheral components of opiate analgesia, effects of loperamide, opioid agonist which does not penetrate the blood-brain barrier, were examined in formalin and acute thermal pain tests in comparison with morphine." | 3.73 | Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists. ( Bespalov, AY; Danysz, W; Sevostianova, N, 2005) |
| " sativa seed polyphenols were prepared, and analgesic and anti-inflammatory effects were studied in mice and rats using the acetic acid-induced writhing, formalin, light tail flick, carrageenan-induced paw edema, and croton oil-induced ear edema tests." | 3.73 | An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols. ( Ghannadi, A; Hajhashemi, V; Jafarabadi, H, 2005) |
| "Intrathecal zaprinast and morphine are effective against acute pain and facilitated pain state." | 3.73 | Synergistic antinociception between zaprinast and morphine in the spinal cord of rats on the formalin test. ( Bae, HB; Choi, JI; Chung, ST; Kim, CM; Kim, SJ; Yoon, MH, 2006) |
| "It has been demonstrated that spinal microglial activation is involved in formalin-induced pain and that minocycline, an inhibitor of microglial activation, attenuate behavioral hypersensitivity in neuropathic pain models." | 3.73 | Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat. ( Cho, IH; Choi, SY; Chung, YM; Jung, SJ; Kim, D; Kim, JS; Lee, H; Lee, SJ; Li, HY; Oh, SB; Park, CK; Park, K; Park, SH; Piao, ZG, 2006) |
| "The analgesic effects of celecoxib, a cyclooxygenase-2 (COX-2) inhibitor, on formalin-induced pain are still controversial." | 3.73 | Analgesic effects of intrathecally administered celecoxib, a cyclooxygenase-2 inhibitor, in the tail flick test and the formalin test in rats. ( Nishiyama, T, 2006) |
| "The present study tested the hypothesis that morphine exposure during the human developmental equivalent of the third trimester would alter inflammatory pain." | 3.73 | Acute and chronic morphine alters formalin pain in neonatal rats. ( Kendig, JJ; Sweitzer, SM; Zhang, G; Zissen, MH, 2006) |
| " As some anticonvulsant drugs also have anti-inflammatory activity, the effects of benzaldehyde semicarbazone (BS) on models of nociception, edema and angiogenesis were investigated." | 3.73 | Antinociceptive, antiedematogenic and antiangiogenic effects of benzaldehyde semicarbazone. ( Andrade, SP; Araújo, F; Beraldo, H; Bertollo, CM; Coelho, MM; Costa, KA; Nascimento, EB; Oliveira, AC; Rocha, LT; Teixeira, LR, 2006) |
| " In this study, we investigated the effects of M58373 on substance P release from sensory neurons in vitro and pain behaviors/responses in rats, compared with mexiletine." | 3.73 | Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats. ( Akada, Y; Amano, K; Fukudome, Y; Itoh, M; Ogawa, S; Yamamoto, I; Yamasaki, F, 2006) |
| "5% formalin injection into the hind paw, acetic acid administration intraperitoneally or neuropathic pain testing consisting of mechanical allodynia (von Frey filament) and thermal hyperalgesia (Plantar test)." | 3.73 | Antinociceptive effects of tetrodotoxin (TTX) in rodents. ( Beaulieu, P; Guindon, J; Lu, S; Marcil, J; Ngoc, AH; Walczak, JS, 2006) |
| "Oxytocin has been implicated in the modulation of somatosensory transmission such as nociception and pain." | 3.73 | Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice. ( Chugh, C; Jain, H; Mediratta, PK; Rathi, N; Reeta, Kh; Sharma, KK, 2006) |
| " The methanolic extract and total alkaloids of Glaucium paucilobum caused graded inhibition of both phases of formalin-induced pain." | 3.73 | Analgesic activity of the methanolic extract and total alkaloids of Glaucium paucilobum. ( Heidar, MR; Mahmoudi, M; Morteza-Semnani, K, 2006) |
| " The present study examined the effects of combinations of dextromethorphan and ketamine, two clinically used N-methyl-D-aspartate (NMDA) receptor antagonists, with amitriptyline on formalin-evoked behaviors and paw edema." | 3.72 | Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. ( Reid, A; Sawynok, J, 2003) |
| "Carrageenin-induced paw edema, tail-flick, formalin, acetic acid-induced abdominal writhing and capsaicin models of pain were carried out." | 3.72 | Anti-inflammatory and antinociceptive activity of diphenyl diselenide. ( Jung, EA; Nogueira, CW; Quinhones, EB; Rocha, JB; Zeni, G, 2003) |
| "In both acute thermal- and inflammatory-induced pain, intrathecally administered midazolam and bupivacaine produced synergistic analgesia with decreased side effects in intrathecally catheterized rats." | 3.72 | Midazolam can potentiate the analgesic effects of intrathecal bupivacaine on thermal- or inflammatory-induced pain. ( Hanaoka, K; Nishiyama, T, 2003) |
| "Bilateral lesions of the RMM with ibotenic acid, a soma-selective neurotoxin, were performed to study their effects on the spontaneous pain-related behaviors and hyperalgesia, which were determined by counting the number of flinching reflex per 5 min (1 h) and by measuring paw withdrawal thermal latency (PWTL) and mechanical threshold (PWMT) to radiant heat and von-Frey filaments to both hind paws in conscious rats, respectively." | 3.72 | Supraspinal contribution to development of both tonic nociception and referred mirror hyperalgesia: a comparative study between formalin test and bee venom test in the rat. ( Chen, HS; Chen, J; Li, MM; Shi, J, 2003) |
| " The antinociceptive effect of 1 was evaluated on chemical (acetic acid, formalin and capsaicin) and thermal (hot plate and tail flick) pain models in mice, using classical standard drugs." | 3.72 | Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla. ( Alexandre-Moreira, MS; Barreiro, EJ; Bolzani, Vda S; Palhares de Miranda, AL; Viegas, C, 2003) |
| " This rat study used adrenalectomy for corticosterone withdrawal and naloxone administration for opioid antagonism in order to study pain behavior and hypophyseal hormone release in the plasma after a formalin test." | 3.72 | Adrenalectomy affects pain behavior of rats after formalin injection. ( Crul, BJ; De Jongh, RF; Meert, TF; Vinken, P; Vissers, KC, 2004) |
| "We investigated the interaction between spinally administered bupivacaine and clonidine using an animal model of acute and inflammatory pain." | 3.72 | Intrathecal clonidine and bupivacaine have synergistic analgesia for acute thermally or inflammatory-induced pain in rats. ( Hanaoka, K; Nishiyama, T, 2004) |
| "Melatonin, the major secretory product of pineal gland has been suggested to play a regulatory role in the circadian rhythm of body activities including the pain sensitivity." | 3.72 | Evaluation of the role of melatonin in formalin-induced pain response in mice. ( Mahajan, P; Mediratta, PK; Ray, M; Sharma, KK, 2004) |
| " We investigated here the effects of ketamine anesthesia on somatosensory processing in the rat spinal cord, thalamus, and cerebral cortex, using the quantitative 2-deoxyglucose mapping technique." | 3.72 | Effects of ketamine anesthesia on central nociceptive processing in the rat: a 2-deoxyglucose study. ( Baraldi, P; Cavazzuti, M; Giuliani, D; Lui, F; Porro, CA; Vellani, V, 2004) |
| ") had no effect in two acute pain models, namely, the acetic acid-induced writhing (visceral pain) and the formalin test (tonic pain)." | 3.72 | Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor. ( Jain, NK; Kulkarni, SK; Padi, SS; Singh, S, 2004) |
| " Antiinflammatory activity was evaluated using carrageenan-induced paw oedema in rats and croton oil-induced ear oedema in mice." | 3.72 | Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. ( Ghannadi, A; Hajhashemi, V; Jafarabadi, H, 2004) |
| " The analgesic investigations were carried out against two types of noxious stimuli, chemical (formalin-induced pain and acetic acid-induced writhing) and thermal (hotplate and tail immersion tests)." | 3.72 | Analgesic and antiinflammatory activities of Erigeron floribundus. ( Asongalem, EA; Dimo, T; Folefoc, GN; Foyet, HS; Kamtchouing, P; Ngogang, J, 2004) |
| "The aqueous and ethanol extracts of the dry leaves of Kalanchoe crenata (300 and 600 mg/kg) were evaluated for their analgesic properties on the pain induced by acetic acid, formalin and heat in mice and by pressure on rats." | 3.72 | Analgesic properties of the aqueous and ethanol extracts of the leaves of Kalanchoe crenata (Crassulaceae). ( Dimo, T; Fotio, AL; Kamanyi, A; Nguelefack, TB; Wansi, SL; Watcho, P, 2004) |
| "The analgesic and anti-inflammatory effects of subcutaneously administered bupivacaine, morphine and tramadol on formalin-induced inflammation were compared." | 3.72 | The analgesic and anti-inflammatory effects of subcutaneous bupivacaine, morphine and tramadol in rats. ( Eti, Z; Gerçek, A; Göğüş, FY; Sav, A, 2004) |
| "Intrathecal administration of propofol had analgesic effects on inflammation-induced acute and facilitated pain but not on thermally-induced acute pain." | 3.72 | Intrathecal propofol has analgesic effects on inflammation-induced pain in rats. ( Hanaoka, K; Matsukawa, T; Nishiyama, T, 2004) |
| ") decreased thermal hyperalgesia observed in carrageenan-induced inflammatory hypersensitivity without affecting paw edema, abolished acetic acid-induced writhing activity in mice, and was shown to reduce mechanical allodynia and thermal hyperalgesia observed in a model of post-operative hypersensitivity and formalin-induced spontaneous pain." | 3.72 | Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities. ( Decker, MW; Gauvin, DM; Honore, P; Lynch, JJ; Mikusa, JP; Wade, CL; Wilson, SG; Wismer, CT; Zhu, CZ, 2004) |
| "5, 5 and 10 mg kg (-1)) was investigated and compared with diclofenac sodium (5 mg kg (-1)) using the formalin-, histamine-, and carrageenan-induced paw oedema and cotton pellet granuloma tests." | 3.71 | Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice. ( Büyükokuroğlu, ME, 2002) |
| "The present study examined the effects of local peripheral and systemic administration of three clinically used excitatory amino acid receptor antagonists (dextromethorphan, memantine, ketamine) on pain behaviors and edema produced by formalin (1." | 3.71 | Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine. ( Reid, A; Sawynok, J, 2002) |
| "The effects of adenosine analogues on pain have been shown to depend on the subtype receptor involved as well as on the nociceptive stimuli and on the route of administration." | 3.71 | Formalin-induced pain and mu-opioid receptor density in brain and spinal cord are modulated by A1 and A2a adenosine agonists in mice. ( Borghi, V; Ilona, O; Labuz, D; Maj, M; Pavone, F; Przewlocka, B, 2002) |
| "To investigate the effect of essential oil of Radix Aangelicae Dahuricae (EOAD) on beta-endorphin Adrenocorticotropic hormone(ACTH), Nitric oxide (NO) and Proopiomelanocortin (POMC) of pain model rats induced by formaldehyde." | 3.71 | [Effect of essential oil of Radix Angelicae Dahuricae on beta-endorphin, ACTH, NO and proopiomelanocortin of pain model rats]. ( Nie, H; Shen, YJ, 2002) |
| " In the present study, the anti-inflammatory properties of total methanol extract isolated from aerial parts of Stachys inflata were investigated in two well-characterised inflammatory models in rats, carrageenan-induced paw oedema and formalin-induced paw licking." | 3.71 | Potent anti-inflammatory activities of hydroalcoholic extract from aerial parts of Stachys inflata on rats. ( Allameh, Z; Eftekhar Sadat, AT; Garjani, A; Hasannia, N; Maleki, N; Nazemiyeh, H; Nilfouroushan, N, 2001) |
| "Incarvillateine (1), a new monoterpene alkaloid carrying a characteristic cyclobutane ring, has been found to show significant antinociceptive activity in a formalin-induced pain model in mice." | 3.71 | Structure-antinociceptive activity studies of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis. ( Chi, YM; Hashimoto, F; Kinjo, J; Nakamura, M; Nakasugi, Y; Nohara, T; Sakurada, S; Yan, WM; Yonezawa, A; Yoshizawa, T, 2001) |
| " We show that the conjugate of arachidonic acid and glycine (N-arachidonylglycine (NAGly)) is present in bovine and rat brain as well as other tissues and that it suppresses tonic inflammatory pain." | 3.71 | Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain. ( Bisogno, T; Burstein, S; Chang, SY; Coop, A; De Petrocellis, L; Di Marzo, V; Huang, SM; Maeda, DY; Petros, TJ; Sivakumar, R; Walker, JM; Zavitsanos, PA; Zipkin, RE, 2001) |
| "Spinally-administered midazolam, a benzodiazepine, and clonidine, an alpha2-adrenergic receptor agonist, have significant synergistic effects on thermally-induced acute and formalin-induced inflammatory pain." | 3.71 | The synergistic interaction between midazolam and clonidine in spinally-mediated analgesia in two different pain models of rats. ( Hanaoka, K; Nishiyama, T, 2001) |
| "In the formalin test, amitriptyline produces different effects on pain behaviors after systemic, spinal administration and peripheral administration." | 3.71 | Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord. ( Allen, GV; Chase, TD; Heughan, CE; Sawynok, J, 2002) |
| "An excess of excitatory pathway activation via N-methyl-D-aspartate (NMDA) receptors has been described in neuropathic pain that responds poorly to morphine." | 3.71 | Magnesium increases morphine analgesic effect in different experimental models of pain. ( Begon, S; Dubray, C; Eschalier, A; Pickering, G, 2002) |
| "By use of the rat formalin test, a model of persistent pain, we examined the effect of a combination of amitriptyline and gabapentin, which are used to treat chronic pain in humans." | 3.71 | The interaction between gabapentin and amitriptyline in the rat formalin test after systemic administration. ( Heughan, CE; Sawynok, J, 2002) |
| "In formalin pain model, the effect of propofol on Fos expression in the spinal cord was examined by means of c -fos oncogene immunohistochemistry and NADPH-d histochemistry." | 3.71 | [Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain]. ( Dai, TJ; Duan, SM; Yan, M; Zhang, LC; Zheng, YM, 2002) |
| "The peripheral antinociceptive effect of the selective COX-2 inhibitor celecoxib in the formalin-induced inflammatory pain was compared with that of resveratrol (COX-1 inhibitor) and diclofenac (non-selective COX inhibitor)." | 3.71 | Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test. ( Alonso-López, R; Asomoza-Espinosa, R; Castañeda-Hernández, G; Granados-Soto, V; Ortiz, MI; Torres-López, JE, 2002) |
| "Peripherally administered nitric oxide itself has no analgesic effect, but it enhances the analgesic effects of peripherally administered morphine during inflammation induced by paw formalin injection in the rat." | 3.70 | The interaction of FK409, a novel nitric oxide releaser, and peripherally administered morphine during experimental inflammation. ( Nozaki-Taguchi, N; Yamamoto, T, 1998) |
| "Effects of atipamezole, an alpha2-adrenoceptor antagonist, in various acute pain tests were studied in the rat." | 3.70 | The effect of a selective alpha2-adrenoceptor antagonist on pain behavior of the rat varies, depending on experimental parameters. ( Hämäläinen, MM; Jyväsjärvi, E; Kauppila, T; Pertovaara, A, 1998) |
| "The tachykinin neuropeptides, substance P and substance K, are produced in nociceptive primary sensory neurons and in many brain regions involved in pain signaling." | 3.70 | Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene. ( Baffi, J; König, M; Mezey, E; Palkovits, M; Reynolds, K; Usdin, T; Zimmer, A; Zimmer, AM, 1998) |
| "The peptide neurotransmitter substance P modulates sensitivity to pain by activating the neurokinin-1 (NK-1) receptor, which is expressed by discrete populations of neurons throughout the central nervous system." | 3.70 | Altered nociception, analgesia and aggression in mice lacking the receptor for substance P. ( Belmonte, C; Cervero, F; De Felipe, C; Doyle, CA; Herrero, JF; Hunt, SP; Laird, JM; O'Brien, JA; Palmer, JA; Smith, AJ, 1998) |
| " We also investigated the effects of ginsenosides on substance P (SP) induced-pain behaviors by i." | 3.70 | Ginsenosides induce differential antinociception and inhibit substance P induced-nociceptive response in mice. ( Choi, HS; Kim, SK; Nah, JJ; Nah, SY; Nam, KY; Shin, YH; Yoon, SR, 1998) |
| "The hypothesis that the naturally occurring analgesic peptide, beta-endorphin, is released in the brain in response to pain had never been directly validated." | 3.70 | Nociceptive stimulus induces release of endogenous beta-endorphin in the rat brain. ( Herzberg, U; Vogel, Z; Yadid, G; Zangen, A, 1998) |
| "The potent analgesic effects of cannabis-like drugs and the presence of CB1-type cannabinoid receptors in pain-processing areas of the brain and spinal cord indicate that endogenous cannabinoids such as anandamide may contribute to the control of pain transmission within the central nervous system (CNS)." | 3.70 | Control of pain initiation by endogenous cannabinoids. ( Calignano, A; Giuffrida, A; La Rana, G; Piomelli, D, 1998) |
| " (1) The therapeutic effects of the cannabinoid anandamide and the putative CB2 agonist palmitoylethanolamide were tested in a model of persistent visceral pain (turpentine inflammation of the urinary bladder)." | 3.70 | The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain. ( Hasnie, FS; Jaggar, SI; Rice, AS; Sellaturay, S, 1998) |
| "The present study shows that meloxicam dose-dependently exhibited systemic antinociceptive action when assessed against neurogenic and inflammatory pain caused by acetic acid, formalin and capsaicin models." | 3.70 | Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice. ( De Freitas, GA; Santos, AR; Vedana, EM, 1998) |
| " We measured arterial plasma ACTH, norepinephrine, and epinephrine in conscious rats after hemorrhage, intravenous insulin, subctaneous formaldehyde solution, cold, or immobilization." | 3.70 | Heterogeneous neurochemical responses to different stressors: a test of Selye's doctrine of nonspecificity. ( Goldstein, DS; Kopin, IJ; Kvetnansky, R; Pacak, K; Palkovits, M; Yadid, G, 1998) |
| "We previously reported that the morphine-induced place preference was attenuated under inflammation produced by the unilateral injection of 2." | 3.70 | Role of the kappa-opioid system in the attenuation of the morphine-induced place preference under chronic pain. ( Kishimoto, Y; Misawa, M; Nagase, H; Suzuki, T; Takeda, F, 1999) |
| "CNS correlates of acute prolonged pain, and the effects of partial blockade of the central beta-endorphin system, were investigated by the quantitative 2-deoxyglucose technique in unanaesthetized, freely moving rats." | 3.70 | CNS pattern of metabolic activity during tonic pain: evidence for modulation by beta-endorphin. ( Baraldi, P; Cavazzuti, M; Corazza, R; Giuliani, D; Panerai, AE; Porro, CA, 1999) |
| "In this study, we compared pain reduction produced by IV drugs (ketamine or alfentanil) with the ability to prevent injury-induced spinal cord changes." | 3.70 | Pre- versus postformalin effects of ketamine or large-dose alfentanil in the rat: discordance between pain behavior and spinal Fos-like immunoreactivity. ( Coderre, TJ; Gilron, I; Quirion, R, 1999) |
| ") gabapentin, administered before and after the injection of formalin into the rat hindpaw, on pain behavior and hemodynamics." | 3.70 | The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat. ( Yaksh, TL; Yoon, MH, 1999) |
| "To study the effect of tetrahydropalmatine (THP) analogs on Fos protein expression induced by formalin-pain and elucidate analgesic mechanism of THP analogs." | 3.70 | Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain. ( Hu, JY; Jin, GZ, 1999) |
| "This study investigates the antinociceptive and the oedema inhibition properties of the novel non-peptide bradykinin (BK) B2 receptor antagonist, NPC 18884." | 3.70 | Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist. ( Alves, RV; Calixto, JB; Chakravarty, S; de Campos, RO; Ferreira, J; Kyle, DJ; Mavunkel, BJ, 1999) |
| "The effect of a commonly used experimental pain-induction procedure (formalin injection into a hindpaw site) on morphine tolerance, withdrawal, and reward was examined in rats." | 3.70 | The role of formalin-induced pain in morphine tolerance, withdrawal, and reward. ( Bardin, L; Kim, JA; Siegel, S, 2000) |
| " The HE of the Phyllanthus species elicited significant inhibition of the capsaicin-induced neurogenic pain, with mean ID(50) values of 8." | 3.70 | Antinociceptive properties of extracts of new species of plants of the genus Phyllanthus (Euphorbiaceae). ( Calixto, JB; De Campos, RO; Filho, VC; Miguel, OG; Santos, AR; Siani, AC; Yunes, RA, 2000) |
| "Tachykinin peptides such as substance P and neurokinin B have been widely studied as mediators of pain transmission." | 3.69 | The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration. ( Krause, JE; McCarson, KE, 1995) |
| "This study examined the effects of hyperglycemia and treatment with the aldose reductase inhibitor, Tolrestat, on the pain behavior evoked by injection of formalin into the dorsum of a single hind paw." | 3.69 | Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats. ( Calcutt, NA; Malmberg, AB; Yaksh, TL; Yamamoto, T, 1994) |
| "Pain associated-anxiety induced by formalin, which resulted in a significant delay in the development of tolerance to morphine antinociception, failed to prevent the development of physical dependence as evidenced by naloxone challenge." | 3.69 | Morphine dependence with or without tolerance in formalin-treated mice: further evidence for the dissociation. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "The mechanism underlying the previous findings that the development of antinociceptive tolerance to morphine was significantly delayed in the presence of inflammatory pain induced by formalin was examined." | 3.69 | Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice. ( Kaneto, H; Rahman, AF; Takahashi, M, 1994) |
| "The aim of the present study was to investigate whether clonidine and morphine interact positively to produce analgesia against the low intensity tonic pain represented by the formalin model in rats." | 3.69 | Morphine, clonidine coadministration in subanalgesic doses: effective control of tonic pain. ( Gurtu, S; Mukerjee, D; Shukla, S, 1994) |
| " with formalin, behavioural correlates of the amount and pattern of Fos-like immunoreactivity (Fos-Ll) (molecular responses to pain) were studied to test if early phase treatment with 75% nitrous oxide or 2% halothane, or both, suppressed subsequent spinal sensitization." | 3.69 | Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin. ( Shieh, JY; Shyu, BC; Sun, WZ, 1996) |
| "Possible central noradrenergic and cholinergic modulation of acute peripheral inflammation was investigated in rats, adopting the formaldehyde-induced pedal inflammation as the experimental model." | 3.69 | Central noradrenergic and cholinergic modulation of formaldehyde-induced pedal inflammation and nociception in rats. ( Dumka, VK; Raviprakash, V; Tandan, SK; Tripathi, HC, 1996) |
| "Morphine-, methamphetamine- and cocaine-induced place preferences under inflammation produced by unilateral injections of 2." | 3.69 | Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine. ( Kishimoto, Y; Misawa, M; Suzuki, T, 1996) |
| "Naloxone has been reported to affect pain and locomotor activity differently depending on the dose." | 3.69 | Influence of low and high doses of naloxone on tonic pain and motor activity in rats. ( Mathur, R; Mena, NB; Nayar, U, 1996) |
| "Drugs that are clinically effective (mexiletine and desipramine) or ineffective (fluoxetine) in the treatment of human neuropathic pain were evaluated for efficacy in rat models involving central sensitization (i." | 3.69 | The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization. ( Hunter, JC; Jett, MF; McGuirk, J; Waligora, D, 1997) |
| "The opioid antagonist, naloxone, produces equivocal effects on the magnitude of nociceptive responses in several animal models of persistent pain, including the formalin test." | 3.69 | Continuous intravenous infusion of naloxone does not change behavioral, cardiovascular, or inflammatory responses to subcutaneous formalin in the rat. ( Basbaum, AI; Peterson, MA; Taylor, BK, 1997) |
| "Possible central serotonergic and histaminergic modulation of acute peripheral inflammation was investigated in rats, adopting the formaldehyde-induced acute pedal inflammation as an experimental model." | 3.69 | Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats. ( Dumka, VK; Raviprakash, V; Tandan, SK; Tripathi, HC, 1996) |
| "We investigated the effect of neonatal capsaicin treatment on formalin-evoked pain behavior and spinal levels of nociceptive neuromodulators using in vivo intrathecal microdialysis in conscious adult rats and age-matched controls." | 3.69 | Neonatal capsaicin treatment abolishes formalin-induced spinal PGE2 release. ( Calcutt, NA; Hua, XY; Malmberg, AB, 1997) |
| "We previously reported that morphine fails to produce analgesic tolerance when administered in the presence of formalin-induced pain, which may be related to activity of the hypothalamic-pituitary-adrenal axis." | 3.69 | The role of corticosterone in the blockade of tolerance to morphine analgesia by formalin-induced pain in the rat. ( Nores, WL; Olson, RD; Soignier, RD; Vaccarino, AL, 1997) |
| "The present study was designed to observe the effect of orphanin FQ (OFQ, also known as 'nociceptin'), a newly-discovered neuropeptide, on pain behavior and morphine analgesia evaluated by formalin test in rats." | 3.69 | Orphanin FQ potentiates formalin-induced pain behavior and antagonizes morphine analgesia in rats. ( Cao, XD; Wu, GC; Xu, SF; Zhu, CB, 1997) |
| "This study evaluated the role of nitric oxide (NO) in spinal cord nociceptive transmission during peripheral inflammation evoked by formalin injection into the rat paw, using N omega-nitro-L-arginine (N-Arg), an NO synthase inhibitor." | 3.68 | Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw. ( Mizuguchi, T; Shimoyama, N; Yamamoto, T, 1993) |
| "The possible influence of painful stimulation and morphine analgesia on hypothalamic met-enkephalin levels, and the possible correlation between this biochemical parameter and animal behaviour was studied." | 3.68 | Changes in hypothalamic met-enkephalin levels of rats induced by painful stimulation and morphine treatment. ( Ayala, J; Del Valle, M; Fuente, T; Hernández, LC; Iglesias, L; López, JM; Seijo, F, 1993) |
| "We have examined whether or not the presence of pain can block the development of tolerance to morphine antinociception in mice." | 3.68 | Development of tolerance to morphine antinociception in mice treated with nociceptive stimulants. ( Kaneto, H; Rahman, AF; Takahashi, M, 1993) |
| "The present study was designed to characterise the analgesia produced by the GABA B agonist baclofen in tonic pain in monkeys." | 3.68 | GABA B mediated analgesia in tonic pain in monkeys. ( Mathur, R; Nayar, U; Sharma, R, 1993) |
| "The present study examined the development of tolerance to morphine analgesia under conditions in which morphine was administered in the presence or absence of pain induced by subcutaneous injection of 50 microliters of 2." | 3.68 | Morphine fails to produce tolerance when administered in the presence of formalin pain in rats. ( Ben-Eliyahu, S; Couret, LC; Kao, B; Kest, B; Liebeskind, JC; Marek, P; Vaccarino, AL, 1993) |
| "A dose of 20 mg/kg of amitriptyline reduced pain in the second phase of the formalin test, which is an animal model of long-lasting pain in humans." | 3.68 | Amitriptyline produces analgesia in the formalin pain test. ( Acton, J; McKenna, JE; Melzack, R, 1992) |
| " In this study, we examined the effect of systemic morphine on Fos-like immunoreactivity (FLI) evoked in the formalin test, a widely used model of persistent pain." | 3.68 | Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord. ( Basbaum, AI; Levine, JD; Menétrey, D; Presley, RW, 1990) |
| "While much evidence implicates substance P (SP), an endogenous neurokinin (NK), as a primary sensory transmitter of acute pain in mammalian spinal cord, its role in continuous (tonic) pain is less clear." | 3.68 | Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model. ( Cowan, A; Larson, AA; Murray, CW, 1991) |
| "Systemic capsaicin and an analogue, olvanil (NE-19550, 4-hydroxy-3-methoxyphenyl methyl-9Z-octadecenamide), were tested for antinociceptive activity in a model of persistent pain produced by the subcutaneous injection of formalin into the rodent hind paw." | 3.68 | Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw. ( Dickenson, A; Dray, A, 1991) |
| "The involvement of the beta-endorphin (B-EP) system during acute prolonged (tonic) pain was investigated by biochemical and behavioral approaches in freely-moving rats after subcutaneous injection of a small amount of a dilute formaldehyde solution (0." | 3.68 | Central beta-endorphin system involvement in the reaction to acute tonic pain. ( Carli, G; Facchinetti, F; Panerai, AE; Porro, CA; Tassinari, G, 1991) |
| "Application of capsaicin to the sciatic nerve reduces responsiveness to pain in the foot-flick test which examines brief, threshold-level pain." | 3.67 | Single nerve capsaicin: effects on pain and morphine analgesia in the formalin and foot-flick tests. ( Abbott, FV; Grimes, RW; Melzack, R, 1984) |
| "The local anesthetic lidocaine was injected into the lateral hypothalamus (LH) of awake, freely moving rats immediately prior to pain testing with either the formalin or the foot-flick test." | 3.67 | Analgesia produced by injection of lidocaine into the lateral hypothalamus. ( Choinière, M; Libman, SM; Melzack, R; Tasker, RAR, 1987) |
| "To confirm that endogenous opioid-peptidergic systems and monoaminergic systems participate in the regulation of pain, the effects of a narcotic antagonist naloxone, inhibitors of enkephalin-degrading enzymes and monoaminergic blockers on persistent pain induced by formalin were investigated." | 3.67 | Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain. ( Kuraishi, Y; Satoh, M; Sugimoto, M; Takagi, H, 1986) |
| "Subcutaneous injection of formaldehyde into mouse hind paw elicited pain responses consisting of licking or biting of the paw, which were observed biphasically." | 3.67 | Effect of neurotropin on hyperalgesia induced by prostaglandin E2, naloxone, melatonin and dark condition in mice. ( Inoki, R; Ohkubo, T; Saito, K; Shibata, M; Takahashi, H, 1987) |
| "The effects of several cholinergic and dopaminergic agents on pain and morphine analgesia were assessed using three pain tests." | 3.66 | Effects of cholinergic and dopaminergic agents on pain and morphine analgesia measured by three pain tests. ( Dennis, SG; Melzack, R, 1983) |
| "Tolerance to morphine analgesia was examined using the Formalin test in which pain lasting about 2 hrs associated with minor tissue injury is produced by subcutaneous injection of dilute Formalin." | 3.66 | Apparent lack of tolerance in the formalin test suggests different mechanisms for morphine analgesia in different types of pain. ( Abbott, FV; Franklin, KB; Ludwick, RJ; Melzack, R, 1981) |
| " Furthermore, the highest therapeutic dose of the extract did not affect motor coordination, exploratory behaviors, general behaviors, and overall well-being of mice, indicating no development of potential CNS adverse effects after administration of the extract." | 2.44 | Curcuma latifolia Roscoe extract reverses inflammatory pain in mice and offers a favorable CNS safety profile. ( Dasuni Wasana, PW; Samun, Y; Sukrong, S; Thongphichai, W; Towiwat, P, 2024) |
| ") administration of either morphine or sufentanil, for example, for any incremental change in stimulus intensity, the degree of right shift in the dose-response relationship was greater for morphine than for sufentanil." | 2.40 | Some new insights into the effects of opioids in phasic and tonic nociceptive tests. ( Chapleo, C; McCormack, K; Prather, P, 1998) |
| "Pain is one of the most frequent causes for patients to seek medical care." | 1.91 | Pramipexole inhibits formalin-induce acute and long-lasting mechanical hypersensitivity via NF-kB pathway in rats. ( Godínez-Chaparro, B; Mendoza-Pérez, F; Pérez-Ramos, J; Santamaria-Anzures, J, 2023) |
| "Corynoline treatment significantly suppressed the paw licking, writhing in the abdominal region, and displayed high nociceptive inhibitory reaction in a dose-related manner." | 1.72 | Antinociceptive and Anti-inflammatory Effect of Corynoline in Different Nociceptive and Inflammatory Experimental Models. ( Lei, F; Yan, Z, 2022) |
| "Acute inflammation was induced by carrageenan (1%) in vivo tests and there were several groups tested." | 1.72 | Antinociceptive, anti-inflammatory and antioxidant activities of the crude ethanolic extract and alkaloid fraction of Waltheria viscosissima A. St. - Hil. (Malvaceae). ( Agra Cavalcante Silva, LH; Alves de Lima, L; Caldas da Silva Dantas Viegas, C; Felício de Sousa Santos, AK; Leite Ferreira, MD; Marinho Braga, R; Nobrega de Almeida, R; Nunes de Andrade, HH; Ribeiro, MD; Sérgio Silva, A; Simões de Assis Cantalice, T; Vanderlei de Souza, MF, 2022) |
| "Itch and pain are both unpleasant, but they are discrete sensations." | 1.72 | Analgesic effect of gastrin-releasing peptide in the dorsal horn. ( Kobayashi, K; Noguchi, K; Okubo, M; Saeki, A; Yamanaka, H, 2022) |
| "Migraine is a complex neurovascular disorder characterized by recurrent attacks of pain and other associated symptoms." | 1.72 | Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior. ( Demartini, C; Francavilla, M; Greco, R; Tassorelli, C; Zanaboni, AM, 2022) |
| "Inflammatory pain is the most important clinical symptom of inflammatory diseases." | 1.72 | Systemic administration of dorsomorphin relieves inflammatory nociception in the mouse formalin test. ( Chenxi, Z; Hao, Y; Jie, K; Mingpeng, Y; Shiyu, D; Sihan, C; Xiao, T; Xinqiang, Y; Yanlin, Z; Yuanyuan, J; Yumeng, H; Zhipeng, Y, 2022) |
| " High dosage (200 μg/mL) of EEVt displayed highly significant inhibitory (p < 0." | 1.62 | The anti-inflammatory and analgesic activities of the ethyl acetate extract of Viburnum taitoense Hayata. ( He, S; Huang, Y; Qiu, L; Wu, X; Xie, J; Xie, Y; Xu, H; Zhang, Q; Zou, L, 2021) |
| "Pain is an unpleasant sensory and emotional experience, often accompanied by the occurrence of a variety of diseases." | 1.62 | Active components of Bupleurum chinense and Angelica biserrata showed analgesic effects in formalin induced pain by acting on Nav1.7. ( Li, W; Liao, X; Liu, Y; Su, Y; Wang, Q; Xu, Y; Yu, Y; Zhang, J; Zhang, S; Zhao, M, 2021) |
| "Cervical spinal cord contusion (CSC) paradigm was employed for induction of neuropathic pain." | 1.62 | Bupleurum falcatum L. alleviates nociceptive and neuropathic pain: Potential mechanisms of action. ( Ahmadimoghaddam, D; Izadidastenaei, Z; Mohammadi, S; Salehi, I; Zarei, M, 2021) |
| " Dose-response for each NSAIDs were created before and after 5 mg/kg of L-NAME i." | 1.56 | Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay. ( Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R, 2020) |
| "Moreover, opioid-induced hyperalgesia was observed after repeated administration of morphine, but not BN-9." | 1.56 | Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia. ( Chen, D; Fang, Q; Li, N; Niu, J; Xiao, J; Xu, B; Xu, K; Zhang, M; Zhang, Q; Zhang, R; Zhao, G; Zhu, H, 2020) |
| "Rubimaillin (Rub) is a naphthoquinone compound extracted from Chinese herbal medicine, and it has various biological activities." | 1.56 | Analgesic action of Rubimaillin in vitro and in vivo. ( Fan, F; Jiang, Z; Yan, W, 2020) |
| "Although the magnitude of the hyperalgesia is dependent on the intensity of the conditioning stimulus, we find that the direction of effect is dependent on the effective test stimulus intensity, with lower-intensity stimuli leading to hyperalgesia and higher-intensity stimuli leading to hypoalgesia." | 1.51 | Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity. ( Austin, JS; Coderre, TJ; Diamond, L; George, N; Macintyre, LC; Martin, LJ; Meluban, L; Mogil, JS; Sotocinal, SG; Tansley, SN, 2019) |
| "miliacea in the treatment of fever with possible anti-nociceptive effects." | 1.51 | Antipyretic and anti-nociceptive effects of methanol extract of leaves of Fimbristylis miliacea in mice model. ( Akter, A; Barek, MA; Basher, MA; Liya, IJ; Roy, R; Sultana, S; Ud Daula, AFMS, 2019) |
| "One quantitative trait locus reached genome-wide significance on chromosome 1 with a support interval of 3." | 1.51 | Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response. ( Bubier, JA; Bult, CJ; Chesler, EJ; Churchill, GA; Gatti, DM; Glidden, NC; Hou, G; Long, KH; Maser, RS; Recla, JM; Robledo, RF; Ryan, JL; Young, EE; Zhang, ZW, 2019) |
| "treatment with oxyntomodulin during the second, but not the first phase." | 1.48 | Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models. ( Hong, JW; Jang, SP; Lee, HJ; Lee, JR; Park, SH; Suh, HW, 2018) |
| " TMJ tissue, trigeminal ganglion, and subnucleus caudalis were collected for TNF-α dosage (ELISA)." | 1.48 | The efficacy of a lectin from Abelmoschus Esculentus depends on central opioid receptor activation to reduce temporomandibular joint hypernociception in rats. ( Alves, SM; Bezerra, MM; Chaves, HV; Clemente-Napimoga, JT; Cristino Filho, G; de Assis, EL; de Lacerda, JTJG; do Val, DR; Freitas, RS; Gadelha, CAA; Gadelha, TS; Gomes, FIF; Pinto, VPT; Vieira, LV, 2018) |
| "Hunger and pain are two competing signals that individuals must resolve to ensure survival." | 1.48 | A Neural Circuit for the Suppression of Pain by a Competing Need State. ( Alhadeff, AL; Betley, JN; De Jonghe, BC; Guo, C; Hantman, AW; Hernandez, E; Holland, RA; Klima, ML; Phillips, SZ; Su, Z, 2018) |
| "Intrathecal AIBP reverses established allodynia in mice in which pain states were induced by the chemotherapeutic cisplatin, intraplantar formalin, or intrathecal LPS, all of which are pro-nociceptive interventions known to be regulated by TLR4 signaling." | 1.48 | Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States. ( An, EJ; Bae, YS; Choi, SH; Corr, M; Kim, J; Low, H; Miller, YI; Ramachandran, R; Schneider, DA; Sviridov, D; Woller, SA; Yaksh, TL, 2018) |
| " Furthermore, DEX showed little neuro-toxicity on the spinal cord neurons, even at the highest dosage used in our study." | 1.46 | Dexmedetomidine relieves formaldehyde-induced pain in rats through both α2 adrenoceptor and imidazoline receptor. ( Leng, YF; Liu, YQ; Wan, ZH; Wang, DG; Yan, X; Zhang, H; Zhang, Y, 2017) |
| "Sinomenine, which is a main bioactive ingredient in Sinomenium acutum, has been reported to have an analgesic effect in diverse pain animal models." | 1.46 | Sinomenine produces peripheral analgesic effects via inhibition of voltage-gated sodium currents. ( Kang, Y; Kim, HB; Lee, JY; Oh, SB; Won, J; Yoon, SY, 2017) |
| "Visceral pain has a greater emotional component than somatic pain." | 1.46 | Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States. ( Baeyens, JM; Cervero, F; Cobos, EJ; Coderre, TJ; Gonzalez-Cano, R; Lehmann, M; Pitcher, MH; Vincent, K, 2017) |
| "Paw oedema was inhibited at all times, and maximal inhibition was at the dose of 100 mg/kg at 2 h after carrageenan injection with 72±2% for EOP and 74±2% for EOS." | 1.46 | Seed and peel essential oils obtained from Campomanesia adamantium fruit inhibit inflammatory and pain parameters in rodents. ( Argandoña, EJ; Arrigo, JD; Cardoso, CA; Correia, CA; Kassuya, CA; Maldonade, IR; Zuntini Viscardi, D, 2017) |
| "Luteolin is a naturally occurring flavonoid with diverse pharmacological properties such as anti-inflammatory, antioxidant and anticancer." | 1.46 | Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice. ( Abdollahzadeh, M; Golmakani, E; Hashemzaei, M; Iranshahi, M; Rezaee, R; Tabrizian, K, 2017) |
| "Pretreatment with naloxone and bicuculline significantly attenuated the reduction of abdominal constrictions produced by all the tested trimethoxy flavones indicating a definite role of opioid and GABAergic mechanisms in the anti-nociceptive effect of trimethoxy flavones." | 1.43 | Anti-nociceptive activity of a few structurally related trimethoxy flavones and possible mechanisms involved. ( Cheriyan, BV; Kadhirvelu, P; Nadipelly, J; Sayeli, V; Shanmugasundaram, J; Subramanian, V, 2016) |
| " In the acute toxicity test, the LD50 estimated for CPE was>5000 mg/kg p." | 1.43 | Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae). ( Alonso-Castro, AJ; Carranza-Álvarez, C; González-Chávez, MM; Hernández-Benavides, DM; Hernández-Morales, A; Zapata-Morales, JR, 2016) |
| "Dehydrocorydaline (DHC) is an alkaloidal component isolated from Rhizoma corydalis." | 1.43 | Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines. ( Chu, SS; Gu, XP; Li, L; Ma, ZL; Sun, Q; Yin, ZY, 2016) |
| " Initial pharmacokinetics evaluation indicated an excellent brain exposure following oral dosing in mice, suggesting that further investigation into the use of alkoxyisoxazoles as σ1 ligands for antinociception is warranted." | 1.43 | Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy. ( Gao, ZB; Gunosewoyo, H; Liu, T; Pang, T; Shi, JJ; Shi, M; Sun, H; Tang, J; Xu, YZ; Yang, F; Yu, LF; Zhang, W; Zheng, YM, 2016) |
| "Pain is one of the most challenging and stressful conditions to patients with sickle cell disease (SCD) and their clinicians." | 1.43 | CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice. ( Chen, Y; DeSimone, J; He, Y; Lu, J; Molokie, RE; Tian, X; Wang, ZJ; Wilkie, DJ; Xiao, C; Yang, C, 2016) |
| "WB4-24 anti-allodynia was prevented by a microglial inhibitor, β-endorphin antiserum and a μ-opioid receptor antagonist." | 1.42 | The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia. ( Fan, H; Gong, N; Li, TF; Ma, AN; Wang, MW; Wang, YX; Wu, XY, 2015) |
| " The main objective of the present work was to enhance the dissolution of MLX and thus its bioavailability by the aid of additives." | 1.42 | Utilization of spray drying technique for improvement of dissolution and anti-inflammatory effect of Meloxicam. ( Alomrani, A; Badran, M; Shazly, G; Zoheir, K, 2015) |
| "In the pleurisy model, induced by carrageenan, treatment with SA inhibited important events involved in inflammatory responses, namely leukocyte influx, plasma leakage, and increased inflammatory mediators (TNF-α, IL-1β, and chemokine CXCL1), in the pleural exudate." | 1.42 | Antinociceptive and anti-inflammatory activity of the siaresinolic acid, a triterpene isolated from the leaves of Sabicea grisea Cham. & Schltdl. var. grisea. ( Barreto, E; Conserva, LM; de Araújo, AF; de Oliveira, AM; de Souza Ferro, JN; Lyra Lemos, RP, 2015) |
| "Pain was induced by formalin (2%) injection into the hind paw." | 1.42 | Microinjection of orexin-A into the rat locus coeruleus nucleus induces analgesia via cannabinoid type-1 receptors. ( Ali Reza, M; Azizi, H; Mirnajafi-Zadeh, J; Mohammad-Pour Kargar, H; Semnanian, S, 2015) |
| "Gabapentin was found to reversibly decrease, but not suppress the flinching frequency of the second response peak only." | 1.40 | Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain. ( Danhof, M; Della Pasqua, O; Taneja, A; Troconiz, IF, 2014) |
| "CFA-induced hind paw mechanical allodynia (P < ." | 1.40 | Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain. ( Grace, PM; Maier, SF; Strand, KA; Watkins, LR, 2014) |
| "Modafinil was administered in the doses of 50, 100 or 200 mg/kg once in acute study and it showed significantly increased tail-flick latency (tfl) and paw-licking latency." | 1.40 | Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole. ( Bhattacharya, SK; Gupta, LK; Gupta, R, 2014) |
| "This LPS-induced hyperalgesia was accompanied by distinct recruitment of supra-spinal regions involved in analgesia as indicated by significantly attenuated Fos-protein induction in the rostral dorsal periaqueductal grey (DPAG) as well as rostral and caudal axes of the ventrolateral PAG (VLPAG)." | 1.40 | Altered formalin-induced pain and Fos induction in the periaqueductal grey of preadolescent rats following neonatal LPS exposure. ( Beagley, KW; Campbell, EJ; Clifton, VL; Dayas, CV; Hodgson, DM; James, MH; Zouikr, I, 2014) |
| "The genus Ajuga is used for the treatment of joint pain, gout, and jaundice in traditional Iranian medicine (TIM)." | 1.40 | Antinociceptive effect of some extracts from Ajuga chamaecistus Ging. ssp. tomentella (Boiss.) Rech. f. aerial parts. ( Ardekani, MR; Davoodipoor, AM; Khanavi, M; Sadati, SN; Sharifzadeh, M, 2014) |
| "Pain is a complex experience that made up of sensory, emotional and cognitive dimensions, and the emotional factors have an important influence on intensity of pain perception." | 1.40 | Intra-periaqueductal gray infusion of zeta inhibitory peptide attenuates pain-conditioned place avoidance in rats. ( Huang, Y; Lei, W; Lu, B; Sun, J; Xiao, C; Yao, J; Zhang, H, 2014) |
| " To determine the possibility of a pharmacokinetic interaction, the oral bioavailability of diclofenac (10 mg/kg) was studied in presence and the absence of curcumin (31 mg/kg)." | 1.40 | Synergistic effect of the interaction between curcumin and diclofenac on the formalin test in rats. ( Castañeda-Hernández, G; Chávez Piña, AE; De Paz-Campos, MA; Ortiz, MI; Zazueta-Beltrán, L, 2014) |
| "Pain is a complex experience composed of sensory and affective components." | 1.39 | Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats. ( Hara, T; Ide, S; Kaneda, K; Koseki, K; Maruyama, C; Minami, M; Naka, T; Ohno, A; Tamano, R; Yoshioka, M, 2013) |
| "Valproic acid (VA) is a major antiepileptic drug, used for several therapeutic indications." | 1.39 | Valproic acid: an anticonvulsant drug with potent antinociceptive and anti-inflammatory properties. ( Correia, AO; da Graça Naffah-Mazzacorati, M; de Castro Brito, GA; de Oliveira Gonçalves, D; Félix, FH; Leal, LK; Neves, KR; Santos Cerqueira, G; Siqueira, RM; Viana, GS; Ximenes, JC, 2013) |
| "Edema was evaluated by the increase in articular diameter (AD; mm), and PL was measured by the amount of Evans blue dye in the synovial fluid (PL; μg/mL)." | 1.39 | Histamine produces opposing effects to serotonin in the knee joint of rats. ( de Oliveira, DT; Eto, C; Souza-Silva, E; Stein, T; Tonussi, CR, 2013) |
| "pretreatment with naloxone (5 µg) reversed the decreased acetic acid-induced writhing response." | 1.39 | Antinociceptive profiles and mechanisms of orally administered coumarin in mice. ( Kang, YJ; Kim, CH; Kim, SJ; Kim, SS; Lim, SM; Park, SH; Sim, YB; Suh, HW, 2013) |
| " Experiments showed that administration of extract (25, 50 and 100 mg kg(-1)) could induced analgesia in a dose-response manner in both phases of formalin test." | 1.38 | Effects of Papaver rhoeas (L.) extract on formalin-induced pain and inflammation in mice. ( Delfan, B; Esfandiari, B; Ghahramani, M; Jafari, F; Mojabi, N; Najafi-Abedi, A; Rahmani, B; Ranjbaran, M; Saeed-Abadi, S; Sahraei, H, 2012) |
| "We evaluated the modulatory role of the groundwater contaminant arsenic on the pharmacodynamic responses of the nonsteroidal analgesic-antipyretic drug ketoprofen and the major pro-inflammatory mediators linked to the mechanism of ketoprofen's therapeutic effects." | 1.38 | Subacute arsenic exposure through drinking water reduces the pharmacodynamic effects of ketoprofen in male rats. ( Ahmad, W; Chanderashekara, HH; Prawez, S; Sankar, P; Sarkar, SN; Tandan, SK, 2012) |
| " At the same time, the pharmacokinetic assay of AGF was also made." | 1.38 | Pharmacological and pharmacokinetic studies with agaricoglycerides, extracted from Grifola frondosa, in animal models of pain and inflammation. ( Cui, B; Han, C, 2012) |
| "Morphine sulfate was used as reference analgesic agent." | 1.38 | Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents. ( Bum, EN; Dawe, A; De Waard, M; Dimo, T; Dzeufiet, PD; Nguimbou, RM; Sidiki, N; Taïwe, GS; Talla, E, 2012) |
| "In carrageenan-induced pleurisy, EOPa (1-100 mg/kg, p." | 1.38 | Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oil from Piper aleyreanum C.DC in rodents. ( Baggio, CH; Ballico, LJ; da Silva, LM; de Souza, LM; Facundo, VA; Gonçalves, HP; Iacomini, M; Lima, DK; Pereira, IT; Rocha Lapa, F; Santos, AR; Werner, MF, 2012) |
| "crassifolius for the treatment of pain and inflammation." | 1.38 | Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract. ( Fang, F; Wang, G; Yang, L; Yu, L; Zhao, J, 2012) |
| "Isofraxidin (IF) is a Coumarin compound that can be isolated from medicinal plants, such as Sarcandra glabra (Thunb." | 1.38 | Isofraxidin exhibited anti-inflammatory effects in vivo and inhibited TNF-α production in LPS-induced mouse peritoneal macrophages in vitro via the MAPK pathway. ( Fan, T; Hu, H; Li, W; Li, Y; Niu, X; Xing, W, 2012) |
| "Ibuprofen was used as a reference compound in each test." | 1.38 | Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu. ( Brownell, L; Hodges, M; Jia, Q; Yimam, M, 2012) |
| "SA daily treatment significantly reduced mechanical allodynia in KOR and cannabinoid receptor 1 (CB1R) sensitive manner." | 1.38 | Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection. ( Aviello, G; Boccella, S; Capasso, R; De Chiaro, M; de Novellis, V; Gatta, L; Guida, F; Izzo, AA; Luongo, L; Maione, S; Marabese, I; Palazzo, E; Zjawiony, JK, 2012) |
| "Our molecular modeling approaches revealed that when receptor desensitization rather than activation activitiesat α4β2* receptors are considered, there is a better correlation between analgesia scores and combined in vitro properties." | 1.38 | Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: correlation with desensitization of α4β2* receptors. ( Bencherif, M; Hammond, PS; Hauser, TA; James, JW; Jordan, KG; Letchworth, SR; Lippiello, PM; Mazurov, AA; Speake, JD; Van Dyke, KM; Xiao, YD; Zhang, J, 2012) |
| "Vitexin, which was isolated from the ethyl acetate extract did not show any activity in all models tested when used alone at the same concentration as it appears in the extract." | 1.38 | Anti-nociceptive activity of Pereskia bleo Kunth. (Cactaceae) leaves extracts. ( Abdul-Wahab, IR; Boylan, F; Fernandes, PD; Guilhon, CC, 2012) |
| "armatum in the treatment of inflammation and pain is warranted." | 1.37 | Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice. ( Cai, CC; Deng, YX; Guo, T; Pan, SL; Wang, YL; Xie, H; Yao, CY, 2011) |
| "Pain was induced by formalin injection into the hindpaw." | 1.37 | Synergistic interaction between intrathecal ginsenosides and morphine on formalin-induced nociception in rats. ( Choi, JI; Kim, CM; Kim, KS; Kim, WM; Kim, YO; Lee, HG; Yoon, MH, 2011) |
| " Chronic administration of minocycline (40 and 80 mg/kg, i." | 1.37 | Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms. ( Dua, K; Kulkarni, SK; Pabreja, K; Padi, SS; Sharma, S, 2011) |
| " The inhibition of oedema formation increased with increasing dosage from 25 to 100mg/kg." | 1.37 | Analgesic effects and anti-inflammatory properties of the crude methanolic extract of Schwenckia americana Linn (Solanaceae). ( Abdullahi, N; Adebisi, I; Chika, A; Jimoh, AO; Umar, MT, 2011) |
| "Evaluation of pain is a critical issue in human pathologies but also in animal experimentation." | 1.37 | Poincaré plot descriptors of heart rate variability as markers of persistent pain expression in freely moving rats. ( Charlet, A; Poisbeau, P; Rodeau, JL, 2011) |
| "Pretreatment with atropine at 5 mg/kg, but not at 2." | 1.37 | Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin. ( Feng, YL; Lin, HM; Liu, YL; Qin, ZH; Reid, PF; Shi, GN; Yang, SL, 2011) |
| "Experiment 1 found hyperalgesia in female and male rats tested on the hot plate immediately after exposure to the elevated plus maze." | 1.37 | Environmentally induced antinociception and hyperalgesia in rats and mice. ( Cornélio, AM; Fugimoto, JS; Mendes-Gomes, J; Morgan, MM; Nunes-de-Souza, RL, 2011) |
| "Morphine (3-9 mg/kg) was injected intraperitoneally (i." | 1.36 | Role of nitric oxide in the rat hippocampal CA1 in morphine antinociception. ( Hashemi, M; Karami, M; Sahebgharani, M; Zarrindast, MR, 2010) |
| "Level of pain was measured in formalin-injected rats in the early (0-10 minutes) and the late (10-60 minutes) phase." | 1.36 | Acupuncture manipulation enhances anti-nociceptive effect on formalin-induced pain in rats. ( Hahm, DH; Hong, MS; Kim, CJ; Kim, GH; Lee, H; Shim, I; Yeom, M; Yin, CS, 2010) |
| "NA-3,4-DCM, dosed systemically (intraperitoneally or per os), was capable of interfering with the development of mechanical hypernociception induced by intraplantar injection of carrageenan and complete Freund adjuvant in mice." | 1.36 | N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system. ( Antonialli, CS; Corrêa, R; da Silva, GF; de Campos-Buzzi, F; Filho, VC; Quintão, NL, 2010) |
| " SO-3 co-administered with morphine left-shift the dose-response curve of morphine in mice acetic acid writhing test and significantly potentiated morphine analgesia in rat formalin test." | 1.36 | Spinal antinociception of synthetic omega-conotoxin SO-3, a selective N-type neuronal voltage-sensitive calcium channel blocker, and its effects on morphine analgesia in chemical stimulus tests in rodent. ( Dong, HJ; Gong, ZH; Huang, PT; Liu, YL; Su, RB; Yan, LD; Zhang, L; Zhou, PL, 2010) |
| "It had less effect on tactile allodynia (CCI)." | 1.35 | Effects of norketamine enantiomers in rodent models of persistent pain. ( Crooks, PA; Hojomat, M; Holtman, JR; Johnson-Hardy, JK; Kleven, M; Wala, EP, 2008) |
| "Chronic pain has been reported to induce apoptosis." | 1.35 | Stress- and non-stress-mediated mechanisms are involved in pain-induced apoptosis in hippocampus and dorsal lumbar spinal cord in rats. ( Ahmadiani, A; Haeri-Rohani, A; Jalalvand, E; Javan, M, 2008) |
| "Pain was assessed using the formalin test (induced by a subcutaneous injection of 50 microl of a 5% formalin solution to the hindpaw)." | 1.35 | Evaluation for the interaction between intrathecal melatonin and clonidine or neostigmine on formalin-induced nociception. ( Huang, LJ; Kim, WM; Kim, YO; Lee, HG; Park, HC; Yoon, MH, 2008) |
| "Morphine pretreatment produced an increase in GABA levels and a decrease in glutamate levels in the first few minutes." | 1.35 | [Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain]. ( Hernández, L; Páez, X; Quiñones, B; Silva, E, 2008) |
| "Atropine did not inhibit the antinociceptive effects of both mepyramine and famotidine on formalin-induced nociception." | 1.35 | Effects of mepyramine and famotidine on the physostigmine-induced antinociception in the formalin test in rats. ( Mojtahedin, A; Tamaddonfard, E; Zanbouri, A, 2008) |
| "Myricetin was also not able to increase the sleeping time induced by pentobarbital, which further indicated that the analgesic effect of myricetin was unrelated to sedation." | 1.35 | Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves. ( Cao, YL; Tong, Y; Wang, SJ; Yang, Y; Zhou, XM, 2009) |
| "It also produced thermal allodynia in response to cold (paw acetone test: 200% increase of allodynia score during week 3-5) and heat (42 degrees C tail immersion test: 15% decrease of withdrawal threshold, from week 2 onward)." | 1.35 | Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies. ( Bardin, L; Depoortère, R; Malfetes, N; Newman-Tancredi, A, 2009) |
| "Cilnidipine is a 1,4-dihydropyridine-derived voltage-dependent calcium channel (VDCC) blocker and suppresses N-type VDCC currents in addition to L-type VDCC currents." | 1.35 | Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker. ( Iwata, S; Koganei, H; Shoji, M, 2009) |
| "CCK is one of the strongest endogenous anti-opioid substances and suppresses morphine tolerance which results from long term use of morphine." | 1.35 | [The effect of formalin-induced pain on CCK in rat spinal cord neurons]. ( Jiang, JF; Li, HA; Li, L; Liang, WH; Si, JQ, 2009) |
| "This produced thermal and mechanical hyperalgesia in rats and mice and augmented mechanical and thermal hyperalgesia seen in the formalin inflammatory pain test." | 1.35 | Intrathecal administration of proteinase-activated receptor-2 agonists produces hyperalgesia by exciting the cell bodies of primary sensory neurons. ( Alier, KA; Andrade-Gordon, P; Cellars, L; Cenac, N; Chapman, K; Endicott, JA; Smith, PA; Stemkowski, PL; Vergnolle, N, 2008) |
| "Tramadol is an atypical analgesic with a unique dual mechanism of action." | 1.35 | The novel compound (+/-)-1-[10-((E)-3-Phenyl-allyl)-3,10-diaza-bicyclo[4.3.1]dec-3-yl]-propan-1-one (NS7051) attenuates nociceptive transmission in animal models of experimental pain; a pharmacological comparison with the combined mu-opioid receptor agoni ( Baek, CA; Erichsen, HK; Munro, G; Nielsen, AN; Nielsen, EØ; Peters, D; Scheel-Kruger, J; Weikop, P, 2008) |
| "morphine pretreatment." | 1.35 | The differential effect of morphine and beta-endorphin administered intracerebroventricularly on pERK and pCaMK-II expression induced by various nociceptive stimuli in mice brains. ( Choi, HW; Jang, JE; Jung, JS; Kwon, MS; Lee, JK; Park, SH; Seo, YJ; Suh, HW, 2008) |
| " In phase II, the cumulative NBI in phase II decreased with the increase in lornoxicam dosage, but the difference was not significant when the dosage above 180 microg." | 1.35 | [Effects of preemptively injected intrathecal lornoxicam on behavior and c-fos protein expression of rat with formalin hurting]. ( Chen, X; Liu, H; Xiao, H; Yang, BX; Yang, Y, 2008) |
| "Since pain is the main syndrome of dysmenorrhea, the present investigation was carried out to evaluate the analgesic activity of LIG in vivo." | 1.34 | Ligustilide attenuates pain behavior induced by acetic acid or formalin. ( Du, J; Ke, Y; Qian, ZM; Wang, C; Yu, Y; Zhu, L, 2007) |
| "The status of neuropathic pain alters the responsiveness to formalin injection in rats." | 1.34 | Altered response to formalin by L5 spinal nerve ligation in rats: a behavioral and molecular study. ( Itano, Y; Kaku, R; Kobayashi, H; Matsuoka, Y; Mizobuchi, S; Morita, K; Sato, T; Yokoyama, M, 2007) |
| "While PRL concentration reaches its peak value within 5 min then returns to the basal level by the end of the 30th min, corticosterone level also starts to rise immediately after formalin administration reaching its highest concentration within 15-30 min, but it remains at this high level during the next 60 min, then it declines and returns to the pre-injection level." | 1.34 | Prolactin response to formalin is related to the acute nociceptive response and it is attenuated by combined application of different stressors. ( Bodnár, I; Kvetnansky, R; Mravec, B; Nagy, GM; Palkovits, M; Tillinger, A; Uhereczky, G, 2007) |
| " Furthermore, A-425619 maintained efficacy in the postoperative pain model after twice daily dosing p." | 1.33 | A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats. ( El Kouhen, R; Faltynek, CR; Gauvin, DM; Gomtsyan, A; Honore, P; Jarvis, MF; Lee, CH; Marsh, K; Mikusa, J; Sullivan, JP; Wismer, CT; Zhong, C; Zhu, CZ, 2005) |
| "Lacosamide is a functionalized amino acid which was initially synthesized as an antiepileptic drug." | 1.33 | Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain. ( Krause, E; Selve, N; Stöhr, T, 2006) |
| "NPB-deficient mice also exhibit hyperalgesia in response to inflammatory pain." | 1.33 | Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain. ( Beuckmann, CT; Garry, MG; Hammer, RE; Kelly, MA; Motoike, T; Richardson, JA; Sinton, CM; Williams, SC; Yanagisawa, M, 2005) |
| "Thermal hyperalgesia (drop of noxious heat threshold) and mechanical hyperalgesia induced by a mild heat injury (51 degrees C, 15s) was smaller in KO mice suggesting a pronociceptive role for TRPV1 receptor in burn injury." | 1.33 | Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice. ( Almási, R; Bölcskei, K; Elekes, K; Helyes, Z; Németh, J; Pethő, G; Pintér, E; Sándor, K; Szabó, Á; Szolcsányi, J, 2005) |
| "Ambroxol's effects were compared with those of gabapentin." | 1.33 | Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain. ( Arndt, K; Gaida, W; Klinder, K; Weiser, T, 2005) |
| " Acute and chronic administration of 1% or 2." | 1.33 | Nitric oxide and c-Jun N-terminal kinase are involved in the development of dark neurons induced by inflammatory pain. ( Ahmadiani, A; Hassanzadeh, P, 2006) |
| "Cilnidipine is a 1,4-dihydropyridine derived L/N-type calcium channel dual blocker possessing neuroprotective and analgesic effects which are related to its N-type calcium channel inhibitory activity." | 1.33 | Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels. ( Fujita, S; Iwata, S; Kito, M; Koganei, H; Matsueda, H; Niwa, S; Ohno, S; Onishi, T; Ono, Y; Saitou, Y; Shoji, M; Takahara, A; Takeda, T; Uneyama, H; Yamamoto, T, 2006) |
| "Nitroglycerin-induced hyperalgesia can be detected as an increase in the nociceptive behavior evoked by the formalin test." | 1.33 | Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test. ( Greco, R; Nappi, G; Sandrini, G; Tassorelli, C; Wang, D, 2006) |
| "Amiloride is a nonspecific blocker of acid-sensing ion channels (ASICs) that have been recently implicated in the mediation of mechanical and chemical/inflammatory nociception." | 1.33 | Sex differences in the effects of amiloride on formalin test nociception in mice. ( Chanda, ML; Mogil, JS, 2006) |
| "Opiates may be used to attenuate chronic pain, but long-term use is complicated by the possible increase in pain over time, escalating dose requirements, and untoward side effects." | 1.33 | Enhancement of morphine antinociception with the peptide N-methyl-D-aspartate receptor antagonist [Ser1]-histogranin in the rat formalin test. ( Basler, A; Hama, A; Sagen, J, 2006) |
| "However, it did not influence thermal hyperalgesia in the zymosan-induced paw inflammation model indicating that GLAST is associated with spontaneous rather than inflammatory nociception." | 1.33 | The glutamate transporter GLAST is involved in spinal nociceptive processing. ( Coste, O; Ehnert, C; Geisslinger, G; Marian, C; Niederberger, E; Schmidtko, A, 2006) |
| " Apomorphine induced a biphasic dose-response relationship, low doses producing hyperalgesia and high doses inducing antinociception." | 1.33 | Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists. ( Constandil, L; Eschalier, A; Hernandez, A; Laurido, C; Pelissier, T, 2006) |
| "Neuropathic pain is a debilitating condition affecting millions of people around the world and is defined as pain that follows a lesion or dysfunction of the nervous system." | 1.33 | Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin. ( Bramwell, S; Corradini, L; Cox, PJ; Dolphin, AC; England, S; Field, MJ; Hendrich, J; Kinloch, RA; Melrose, H; Offord, J; Stott, E; Su, TZ; Webb, T; Williams, D; Winks, J, 2006) |
| "Morphine (1-6 mg/kg) was administered systemically before or after the early phase, and its ability to affect the late phase was investigated." | 1.32 | Effects of morphine on formalin-induced nociception in rats. ( Bespalov, A; Danysz, W; Sevostianova, N; Zvartau, E, 2003) |
| "Nitroglycerin is a nitric oxide (NO) donor which activates nuclei involved in nociceptive transmission following systemic administration." | 1.32 | Nitroglycerin induces hyperalgesia in rats--a time-course study. ( Greco, R; Nappi, G; Sandrini, G; Sandrini, M; Tassorelli, C; Wang, D, 2003) |
| "Lactoferrin (LF) is a multifunctional protein that is found in milk, neutrophils, and other biological fluids, and its receptors have also been identified in the central nervous system." | 1.32 | Lactoferrin enhances opioid-mediated analgesia via nitric oxide in the rat spinal cord. ( Ando, K; Harada, E; Hayashida, K; Shimizu, H; Takeuchi, T, 2003) |
| "Pain is a multidimensional conscious experience including sensory and negative affective components." | 1.32 | Differential contributions of the basolateral and central nuclei of the amygdala in the negative affective component of chemical somatic and visceral pains in rats. ( Minami, M; Nakagawa, T; Satoh, M; Tanimoto, S; Yamauchi, Y, 2003) |
| "Tetramethylpyrazine (TMP) has been used in traditional Chinese medicine as an analgesic for dysmenorrhea." | 1.32 | Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat. ( Gao, Y; Liang, SD; Mu, SN; Xu, BH; Xu, CS, 2004) |
| "Preterm infants undergoing untreated, repeated painful procedures as part of their early experience are more likely to behave differently to pain as they mature than infants who were born at term and did not experience excessive exogenous pain." | 1.32 | The effects of exposure to repeated minor pain during the neonatal period on formalin pain behaviour and thermal withdrawal latencies. ( Johnston, CC; Walker, CD, 2003) |
| "These arrhythmias occurred also with a short latency (mean 8." | 1.32 | Ventricular arrhythmias triggered by alerting stimuli in conscious rabbits pre-treated with dofetilide. ( Blessing, WW; De Pasquale, CG; Nalivaiko, E, 2004) |
| " Thus, studies on the prevention and management of chronic pain should focus on preemptive or long-term administration of NMDA receptor antagonists." | 1.32 | Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain. ( Aliev, K; Belozertseva, IV; Bespalov, AY; Danysz, W; Malyshkin, AA; Medvedev, IO; Parsons, CG; Sevostianova, NY; Sukhotina, IA; Zvartau, EE, 2004) |
| ") significantly inhibited phenylquinone-evoked writhing movements in mice, but within this dose range no clear dose-response correlation was found." | 1.32 | Analgesic effect of TT-232, a heptapeptide somatostatin analogue, in acute pain models of the rat and the mouse and in streptozotocin-induced diabetic mechanical allodynia. ( Almási, R; Bölcskei, K; Börzsei, R; Elekes, K; Helyes, Z; Kéri, G; Petho, G; Pintér, E; Szabó, A; Szolcsányi, J; Szuts, T, 2004) |
| "Corticosterone plasma levels were increased by formalin only in estrogen-treated animals, independently of naloxone." | 1.31 | Role of gonadal hormones in formalin-induced pain responses of male rats: modulation by estradiol and naloxone administration. ( Aloisi, AM; Ceccarelli, I, 2000) |
| "Morphine is an agonist of mu-opioid receptors and inhibits N-type VSCC channels via a G-protein coupling mechanism." | 1.31 | Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats. ( Bowersox, SS; Gao, D; Pettus, M; Phillips, C; Wang, YX, 2000) |
| "Moxonidine is a mixed I(1) imidazoline/alpha(2)moxonidine=morphine." | 1.31 | Effects of the I(1) imidazoline/alpha(2)-adrenergic receptor agonist moxonidine in comparison with clonidine in the formalin test in rats. ( Lutz, EA; Shannon, HE, 2000) |
| " After obtaining dose-response curves for each agent, combinations of morphine and AP-5, ACEA 1021 or ACEA 2752 were tested for their effect on the number of flinches in the formalin test and for associated side-effects, such as motor disturbances, flaccidity, and agitation/allodynia." | 1.31 | Interaction between intrathecal morphine and glutamate receptor antagonists in formalin test. ( Nishiyama, T, 2000) |
| "In conclusion, NO and PGE2 affect the hyperalgesia induced by excitatory amino acids." | 1.31 | The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats. ( Huh, IH; Lee, TS; Park, YH; Shin, CY; Sohn, UD, 2000) |
| "The pain was treated with lidocaine ointment and sitz baths with partial success." | 1.31 | Complications following formalin installation in the treatment of radiation induced proctitis. ( Belin, B; Efron, J; Nogueras, JJ; Pikarsky, AJ; Weiss, EG; Wexner, SD, 2000) |
| "When imipramine was used during development of tolerance, either on days 1 and 2 or on days 2 and 3, the morphine tolerance in the second phase of the test was reduced." | 1.31 | Effect of imipramine on tolerance to morphine antinociception in the formalin test. ( Sahebgharani, M; Shaverdian, S; Zarrindast, MR, 2000) |
| "In conclusion, REM sleep deprivation induces a significant increase in the behavioral responses to noxious mechanical, thermal and electrical stimuli in rats." | 1.31 | Effects of rapid eye movement (REM) sleep deprivation on pain sensitivity in the rat. ( Alloui, A; Dubray, C; Eschalier, A; Hakki Onen, S; Jourdan, D, 2001) |
| "PGE2 could induce mechanical allodynia in EP1(+/+), EP3(+/+) and EP3(-/-) mice, but not in EP1(-/-) mice." | 1.31 | Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice. ( Ichikawa, A; Ito, S; Kobayashi, T; Minami, T; Nakano, H; Narumiya, S; Sugimoto, Y; Ushikubi, F, 2001) |
| "Peak of the licking was reached at 2." | 1.31 | Effects of different concentrations of formalin on paw edema and pain behaviors in rats. ( Jeong, YS; Lee, IO, 2002) |
| "Pretreatment with naloxone abolished this antinociceptive activity both in the hot-plate test and in the first phase of the formalin test without affecting the serum concentration of paracetamol." | 1.30 | Naloxone-reversible antinociception by paracetamol in the rat. ( Ottani, A; Pini, LA; Sandrini, M; Vitale, G, 1997) |
| "formalin-induced hyperalgesia, like illness-induced hyperalgesia, is dependent on the nucleus raphe magnus (NRM) but independent of the nucleus reticularis paragigantocellularis (NRPgc)." | 1.30 | Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias. ( Maier, SF; Roemer, B; Watkins, LR; Wiertelak, EP, 1997) |
| "Two approaches were used." | 1.30 | Role of spinal gamma-aminobutyric acidA receptors in formalin-induced nociception in the rat. ( Hammond, DL; Kaneko, M, 1997) |
| "or i." | 1.30 | Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action. ( Beirith, A; Calixto, JB; Creczynski-Pasa, TB; Rodrigues, AL; Santos, AR, 1998) |
| "Gabapentin (GP) has been shown to have antihyperalgesic properties and the site of drug action is reported to be the central nervous system." | 1.30 | Attenuation of formalin-induced nociceptive behaviors following local peripheral injection of gabapentin. ( Carlton, SM; Zhou, S, 1998) |
| "Posttreatment with yohimbine and methysergide showed a significantly greater increase in the number of flinches in phase 2." | 1.30 | Formalin-induced nociception activates a monoaminergic descending inhibitory system. ( Kawamata, M; Kawamata, T; Namiki, A; Omote, K, 1998) |
| " However, when animals were pre-treated with BCG, the dose-response curves for both B1 agonists were shifted 2 to 8-fold to the left." | 1.30 | Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice. ( Calixto, JB; de Campos, RO; Henriques, MG, 1998) |
| "Nocistatin is a 17 amino acid peptide and is processed from prepronociceptin." | 1.30 | Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test. ( Sakashita, Y; Yamamoto, T, 1999) |
| "The present study was designed to evaluate the oral efficacy and bioavailability of ketamine." | 1.30 | Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine. ( Elliott, KJ; Gorman, AL; Inturrisi, CE; Shimoyama, M; Shimoyama, N, 1999) |
| "Pretreatment with dextromethorphan at 60 mg/kg s." | 1.29 | Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c-fos mRNA. ( Brodsky, M; Elliott, KJ; Foley, KM; Hynansky, AD; Inturrisi, CE, 1995) |
| " formalin, enhanced the second-but not the first-phase nociceptive responses, whereas it was without significant effects at 3 micrograms per paw, and conversely, produced antinociception at 10 micrograms per paw, resulting in a bell-shaped dose-response curve." | 1.29 | Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation. ( Kawabata, A; Manabe, S; Manabe, Y; Takagi, H, 1994) |
| "Caffeine did not produce an anti-inflammatory effect as determined by hindpaw plethysmometry, suggesting that antinociception was not secondary to an anti-inflammatory action." | 1.29 | Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms. ( Doak, GJ; Reid, AR; Sawynok, J, 1995) |
| " To examine the properties of various pain rating methods we established dose-response relations for formalin injected in the plantar surface of one hind paw, and the analgesic effects of morphine and amphetamine using the most frequently reported behavioural measures of pain (favouring, lifting, licking and flinching/shaking of the injured paw) and combinations of these." | 1.29 | The formalin test: scoring properties of the first and second phases of the pain response in rats. ( Abbott, FV; Franklin, KBJ; Westbrook, FR, 1995) |
| "Naloxone-precipitated withdrawal symptoms were significantly greater in rats that received morphine in the absence of pain than in rats that received morphine in the presence of pain." | 1.29 | Formalin-induced pain antagonizes the development of opiate dependence in the rat. ( Couret, LC; Vaccarino, AL, 1993) |
| "Intractable pains have been described after surgical or accidental lesions in the peripheral or central nervous system." | 1.29 | The role of previous nociceptive input in development of autotomy following cordotomy. ( Atweh, SF; Jabbur, SJ; Saadé, NE; Shihabuddin, LS, 1993) |
| "25% formalin and shifted the dose-response relation for the effect of morphine on the second phase of the pain response produced by 1." | 1.29 | The effect of lesions of the dorsolateral funiculus on formalin pain and morphine analgesia: a dose-response analysis. ( Abbott, FV; Franklin, KBJ; Hong, Y, 1996) |
| " Dose-response curves for each agonist were statistically parallel and equally efficacious (100% antinociception)." | 1.28 | Systemic injections of alpha-1 adrenergic agonists produce antinociception in the formalin test. ( Connell, BJ; Tasker, RAR; Yole, MJ, 1992) |
| "Flurbiprofen (50 mg kg-1) was inactive." | 1.28 | Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse. ( Babbedge, RC; Gaffen, Z; Hart, SL; Moore, PK; Morgan, CV; Wallace, P, 1992) |
| "Both midazolam and morphine were effective in reducing the nociceptive response of the second phase of this biphasic pain test." | 1.28 | Intrathecal midazolam versus intrathecal morphine in orofacial nociception: an experimental study in rats. ( Aigouy, L; Fondras, JC; Pajot, J; Schoeffler, P; Woda, A, 1992) |
| "When lidocaine was injected 0 or 10 min prior to formalin injection, a time-dependent increase in analgesia in the late phase was again observed." | 1.28 | Temporal processes of formalin pain: differential role of the cingulum bundle, fornix pathway and medial bulboreticular formation. ( Melzack, R; Vaccarino, AL, 1992) |
| "Substance P (SP) has been widely proposed as being involved in the transmission of nociceptive information in the dorsal horn of the spinal cord." | 1.28 | Release of substance P into the superficial dorsal horn following nociceptive activation of the hindpaw of the rat. ( Goldstein, BD; McCarson, KE, 1991) |
| "Aspirin given orally was not consistently antinociceptive in either phase of the formalin test." | 1.28 | Standardization of the rat paw formalin test for the evaluation of analgesics. ( Cowan, A; Wheeler-Aceto, H, 1991) |
| ") against chemically induced cutaneous pain in rats, was assessed from cumulative dose-response experiments and the formalin test." | 1.28 | Analgesia produced by intrathecal administration of the kappa opioid agonist, U-50,488H, on formalin-evoked cutaneous pain in the rat. ( Hernández, A; Paeile, C; Pelissier, T; Saavedra, H; Soto-Moyano, R, 1990) |
| "Substance P (SP) has been proposed as a mediator of nociception in the dorsal horn of the spinal cord." | 1.28 | Naloxone blocks the formalin-induced increase of substance P in the dorsal horn. ( Goldstein, BD; McCarson, KE, 1989) |
| "Morphine antinociception reaches ceiling at doses that are devoid of such peripheral actions." | 1.27 | Peripheral and central antinociceptive actions of ethylketocyclazocine in the formalin test. ( Abbott, FV, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (3.76) | 18.7374 |
| 1990's | 269 (20.24) | 18.2507 |
| 2000's | 517 (38.90) | 29.6817 |
| 2010's | 420 (31.60) | 24.3611 |
| 2020's | 73 (5.49) | 2.80 |
| Authors | Studies |
|---|---|
| McNamara, CR | 1 |
| Mandel-Brehm, J | 1 |
| Bautista, DM | 1 |
| Siemens, J | 1 |
| Deranian, KL | 1 |
| Zhao, M | 3 |
| Hayward, NJ | 1 |
| Chong, JA | 1 |
| Julius, D | 1 |
| Moran, MM | 1 |
| Fanger, CM | 1 |
| Macpherson, LJ | 1 |
| Xiao, B | 1 |
| Kwan, KY | 1 |
| Petrus, MJ | 1 |
| Dubin, AE | 1 |
| Hwang, S | 1 |
| Cravatt, B | 1 |
| Corey, DP | 1 |
| Patapoutian, A | 1 |
| Singh, NR | 1 |
| Mishra, L | 1 |
| Pawar, AM | 1 |
| Kurniawati, N | 1 |
| Wahjuningrum, DA | 1 |
| Hossaini, M | 2 |
| Duraku, LS | 2 |
| Kohli, SK | 1 |
| Jongen, JL | 1 |
| Holstege, JC | 2 |
| Murotani, T | 1 |
| Ishizuka, T | 1 |
| Nakazawa, H | 1 |
| Wang, X | 3 |
| Mori, K | 1 |
| Sasaki, K | 1 |
| Ishida, T | 1 |
| Yamatodani, A | 1 |
| Shokrollahi, M | 2 |
| Samadizadeh, M | 2 |
| Khalili, M | 4 |
| Sobhanian, SA | 2 |
| Ahmadi, A | 4 |
| Li, YL | 2 |
| Chang, XR | 1 |
| Ma, JT | 1 |
| Zhao, X | 2 |
| Yin, LT | 1 |
| Yan, LJ | 1 |
| Guo, JH | 1 |
| Zhang, C | 2 |
| Yang, XR | 2 |
| He, L | 1 |
| Zhou, Y | 2 |
| Wan, G | 1 |
| Wang, W | 4 |
| Zhang, N | 1 |
| Yao, L | 1 |
| Ismail, CAN | 1 |
| Ghazali, AK | 1 |
| Suppian, R | 2 |
| Abd Aziz, CB | 1 |
| Long, I | 2 |
| Ng, SY | 1 |
| Ariffin, MZ | 1 |
| Khanna, S | 8 |
| Lei, F | 1 |
| Yan, Z | 1 |
| Ejiri, Y | 1 |
| Uta, D | 1 |
| Ota, H | 1 |
| Mizumura, K | 1 |
| Taguchi, T | 2 |
| Caldas da Silva Dantas Viegas, C | 1 |
| Sérgio Silva, A | 1 |
| Marinho Braga, R | 1 |
| Nunes de Andrade, HH | 1 |
| Felício de Sousa Santos, AK | 1 |
| Leite Ferreira, MD | 1 |
| Ribeiro, MD | 1 |
| Agra Cavalcante Silva, LH | 1 |
| Alves de Lima, L | 1 |
| Nobrega de Almeida, R | 1 |
| Vanderlei de Souza, MF | 1 |
| Simões de Assis Cantalice, T | 1 |
| Muñoz-Lora, VRM | 1 |
| Dugonjić Okroša, A | 1 |
| Matak, I | 1 |
| Del Bel Cury, AA | 1 |
| Kalinichev, M | 1 |
| Lacković, Z | 2 |
| Gaspar, JC | 2 |
| Okine, BN | 3 |
| Dinneen, D | 1 |
| Roche, M | 6 |
| Finn, DP | 10 |
| Louçano, M | 1 |
| Oliveira, J | 1 |
| Martins, I | 2 |
| Vaz, R | 1 |
| Tavares, I | 2 |
| Khalouzadeh, F | 1 |
| Azizi, H | 2 |
| Semnanian, S | 5 |
| Zhang, X | 4 |
| Li, J | 1 |
| Guan, L | 1 |
| Huang, H | 2 |
| Bai, X | 1 |
| Zhang, K | 1 |
| Guo, J | 1 |
| Wu, S | 1 |
| Ouyang, H | 1 |
| Zhou, SB | 1 |
| Xue, M | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Subanesthetic Sevoflurane for Treatment-Resistant Depression: A Proof-of-Concept Trial[NCT05008939] | 15 participants (Anticipated) | Interventional | 2021-08-31 | Not yet recruiting | |||
| A Phase II, Randomized, Double Blind, Double Dummy, Active-Controlled Clinical Trial to Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes Mellitus[NCT05343767] | 198 participants (Actual) | Interventional | 2018-09-12 | Completed | |||
| Itch Relieving Effect of Botox: a Study in Healthy Subjects[NCT02639052] | Phase 1/Phase 2 | 35 participants (Actual) | Interventional | 2016-02-29 | Completed | ||
| Intravesical Botulinum Toxin A Injection in Treatment of Interstitial Cystitis Refractory to Conventional Treatment - A Prospective, Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial[NCT01969773] | Phase 2 | 60 participants (Actual) | Interventional | 2012-12-31 | Completed | ||
| Intraoral Administration of Onabotulinum Toxin A for Continuous Neuropathic Pain: a Single Subject Experimental Design[NCT03848143] | Phase 2 | 10 participants (Anticipated) | Interventional | 2019-09-11 | Recruiting | ||
| A 12-week Prospective, Double-blinded, Randomized, Multicenter Study of Low Dose and Medium Dose Botulinum Toxin Type A (Dysport® ) Injection for Migraine Prophylaxis.[NCT00258609] | Phase 3 | 128 participants | Interventional | 2003-02-28 | Completed | ||
| Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy[NCT03571334] | Phase 2 | 40 participants (Anticipated) | Interventional | 2020-07-08 | Recruiting | ||
| Pilot Study to Assess the Efficacy of Botulinum Toxin B (Myobloc®) Treatment of Paravertebral Muscles on Pain and Disability in Subjects Suffering From Acute Low Back Pain[NCT00384579] | Phase 4 | 0 participants (Actual) | Interventional | 2008-02-29 | Terminated (stopped due to No eligible candidates in 2 years of recruiting) | ||
| Understanding the Anatomy and Physiology of the Sensory Experience and Its Role in Generating Tics in Tourette Syndrome[NCT00755339] | 54 participants (Actual) | Observational | 2008-09-15 | Completed | |||
| Effect of Ambroxol on the Inflammatory Markers and Clinical Outcome of Patients With Diabetic Peripheral Neuropathy[NCT05558878] | 80 participants (Anticipated) | Interventional | 2022-10-01 | Not yet recruiting | |||
| Utility of Pre-Operative Stellate Ganglion Blockade for Pain Control in Unilateral Head and Neck Cancer Surgery[NCT03714906] | 22 participants (Actual) | Interventional | 2019-03-22 | Terminated (stopped due to Slow accrual, lack of benefit between intervention and control arms on interim analysis) | |||
| Effects of Oxytocin Administration on Social Influence Effects on Pain[NCT03060031] | Phase 1 | 51 participants (Actual) | Interventional | 2017-06-21 | Completed | ||
| Iontophoresis Effects on Senses[NCT02487914] | Phase 2/Phase 3 | 30 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors[NCT05684367] | 24 participants (Anticipated) | Interventional | 2023-11-29 | Recruiting | |||
| The Effect of Local Anesthesia With Lidocaine During Insertion and Removal of Nasal Packing[NCT04519463] | Early Phase 1 | 60 participants (Anticipated) | Interventional | 2020-09-30 | Not yet recruiting | ||
| Antipruritic Effect of Topical Ketamine, Amitriptyline, and Lidocaine[NCT03096444] | Phase 2 | 13 participants (Actual) | Interventional | 2017-05-23 | Terminated (stopped due to Efficacy was not seen after interim analysis) | ||
| Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Postoperative Pain and Inflammation Following Below Knee Fracture Fixation: A Pilot Study.[NCT05317676] | Phase 2 | 0 participants (Actual) | Interventional | 2023-05-31 | Withdrawn (stopped due to Sponsor suspending temporarily.) | ||
| Effects of Percutaneous Neuromodulation on Plasticity in the Somatosensory System[NCT04475133] | 29 participants (Actual) | Interventional | 2020-08-13 | Completed | |||
| Placebo-Controlled Crossover Trial of Levetiracetam on Ethanol Intake[NCT01168687] | 46 participants (Actual) | Interventional | 2008-11-30 | Completed | |||
| Magnesium Oral Supplementation to Reduce Pain in Patients With Severe Peripheral Arterial Occlusive Disease: The MAG-PAPER Randomized Clinical Trial[NCT02455726] | 150 participants (Anticipated) | Interventional | 2015-09-30 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
A secondary endpoint is to see if Botox has a relieving effect on heat pain using a pain visual analog scale (VAS) intensity scale as an outcome measure. The pain VAS intensity scale ranges from a minimum of 0 (no pain - best) to a maximum of 10 (maximum pain - worst). Participants will rate pain intensity after pain is induced with a heat thermode. (NCT02639052)
Timeframe: Baseline, 1 week, 1 month, 3 months
| Intervention | units on a scale (Mean) | ||||
|---|---|---|---|---|---|
| Baseline | 1 Week | 1 Month | 3 Months | All Visits | |
| Botox | 3.6 | 3.7 | 3.7 | 4.1 | 3.8 |
| Saline | 3.7 | 3.7 | 4.1 | 4.3 | 4.0 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: 1 Month from Baseline
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 Month (Visit 3), 0 seconds | 1 Month (Visit 3), 30 seconds | 1 Month (Visit 3), 60 seconds | 1 Month (Visit 3), 90 seconds | 1 Month (Visit 3), 120 seconds | 1 Month (Visit 3), 150 seconds | 1 Month (Visit 3), 180 seconds | 1 Month (Visit 3), 210 seconds | 1 Month (Visit 3), 240 seconds | 1 Month (Visit 3), 270 seconds | 1 Month (Visit 3), 300 seconds | 1 Month (Visit 3), All Times | |
| Botox | 3.2 | 5.0 | 5.1 | 4.3 | 3.5 | 2.3 | 1.5 | 0.9 | 0.7 | 0.3 | 0.2 | 2.5 |
| Saline | 3.8 | 6.2 | 6.2 | 5.7 | 4.5 | 3.3 | 2.2 | 1.4 | 0.9 | 0.6 | 0.4 | 3.2 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: 1 week from Baseline
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 Week (Visit 2), 0 seconds | 1 Week (Visit 2), 30 seconds | 1 Week (Visit 2), 60 seconds | 1 Week (Visit 2), 90 seconds | 1 Week (Visit 2), 120 seconds | 1 Week (Visit 2), 150 seconds | 1 Week (Visit 2), 180 seconds | 1 Week (Visit 2), 210 seconds | 1 Week (Visit 2), 240 seconds | 1 Week (Visit 2), 270 seconds | 1 Week (Visit 2), 300 seconds | 1 Week (Visit 2), All Times | |
| Botox | 3.3 | 5.4 | 5.9 | 4.9 | 3.7 | 2.7 | 2.0 | 1.4 | 0.9 | 0.6 | 0.4 | 2.8 |
| Saline | 4.0 | 6.7 | 6.9 | 6.1 | 4.8 | 3.8 | 2.7 | 1.9 | 1.3 | 0.9 | 0.7 | 3.6 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: 3 Months from Baseline
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 Months (Visit 4), 0 seconds | 3 Months (Visit 4), 30 seconds | 3 Months (Visit 4), 60 seconds | 3 Months (Visit 4), 90 seconds | 3 Months (Visit 4), 120 seconds | 3 Months (Visit 4), 150 seconds | 3 Months (Visit 4), 180 seconds | 3 Months (Visit 4), 210 seconds | 3 Months (Visit 4), 240 seconds | 3 Months (Visit 4), 270 seconds | 3 Months (Visit 4), 300 seconds | 3 Months (Visit 4), All Times | |
| Botox | 2.3 | 4.5 | 4.9 | 4.6 | 3.8 | 3.0 | 2.1 | 1.5 | 1.0 | 0.7 | 0.3 | 2.6 |
| Saline | 3.3 | 5.4 | 5.9 | 5.2 | 4.7 | 3.6 | 2.8 | 1.9 | 1.4 | 0.9 | 0.6 | 3.2 |
The primary endpoint is to test the antipruritic effect of Botox using an itch visual analog scale (VAS) intensity scale as an outcome measure. The itch VAS intensity scale ranges from a minimum of 0 (no itch - best) to a maximum of 10 (maximum itch - worst). Participants will rate itch intensity after itch is induced with cowhage. (NCT02639052)
Timeframe: Baseline (Visit 1)
| Intervention | units on a scale (Mean) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Baseline (Visit 1), 0 seconds | Baseline (Visit 1), 30 seconds | Baseline (Visit 1), 60 seconds | Baseline (Visit 1), 90 seconds | Baseline (Visit 1), 120 seconds | Baseline (Visit 1), 150 seconds | Baseline (Visit 1), 180 seconds | Baseline (Visit 1), 210 seconds | Baseline (Visit 1), 240 seconds | Baseline (Visit 1), 270 seconds | Baseline (Visit 1), 300 seconds | Baseline (Visit 1), All Times | |
| Botox | 4.5 | 6.5 | 6.8 | 5.9 | 5.1 | 4.1 | 2.8 | 2.0 | 1.3 | 0.9 | 0.6 | 3.7 |
| Saline | 4.3 | 6.3 | 6.5 | 6.3 | 5.1 | 3.9 | 2.8 | 2.0 | 1.4 | 0.9 | 0.9 | 3.7 |
"Peak itch intensity between the vehicle and 4 other active treatments (individual ketamine, amitriptyline, or lidocaine, and KeAmLi-combo). Itch intensity was measured on a 100mm scale visual analog scale for 10 minutes. 0 was weighted with no itch and 100 was weighted with most itch imaginable." (NCT03096444)
Timeframe: 10 minutes
| Intervention | Intensity score (Mean) |
|---|---|
| Topical KeAmLi Combo | 62.7 |
| Topical Ketamine | 63.1 |
| Topical Amitriptyline | 69.2 |
| Topical Lidocaine | 65.8 |
| Topical Vehicle | 61.9 |
Assess mechanical detection and pain thresholds using von Frey filaments stimulators (measured in force mN) to calculate the final threshold as the geometric mean of five series of ascending and descending stimuli. (NCT03096444)
Timeframe: 5 minutes
| Intervention | mN (Mean) | |
|---|---|---|
| Mechanical Detection Threshold | Mechanical Pain Threshold | |
| Topical Amitriptyline | 3.573423965 | 152.4768146 |
| Topical KeAmLi Combo | 3.519376956 | 152.3293608 |
| Topical Ketamine | 3.464204768 | 135.9 |
| Topical Lidocaine | 3.546037659 | 126.9 |
| Topical Vehicle | 3.525692637 | 148.7138273 |
Two standardized quantitative sensory tests are performed to measure warmth detection threshold (assesses the threshold of which warmth sensation is first detected) and heat pain threshold (assesses the threshold at which heat pain sensation is first detected). Measured in change in celsius. (NCT03096444)
Timeframe: 3 minutes
| Intervention | Degrees celsius (Mean) | |
|---|---|---|
| Warm Detection Threshold | Heat Pain Threshold | |
| Topical Amitriptyline | 33.9 | 40.0 |
| Topical KeAmLi Combo | 33.6 | 39.8 |
| Topical Ketamine | 34.0 | 40.0 |
| Topical Lidocaine | 33.7 | 39.4 |
| Topical Vehicle | 33.8 | 39.7 |
The primary outcome of this study is to determine the effect of levetiracetam on alcohol consumption as measured by change in # of drinks during each treatment period. (NCT01168687)
Timeframe: During each 14 day treatment period
| Intervention | number of drinks per treatment period (Mean) |
|---|---|
| All Subjects (n = 46) Placebo | 41.2 |
| All Subjects (n = 46) Levetiracetam | 45.4 |
11 reviews available for formaldehyde and Ache
| Article | Year |
|---|---|
Evidence for spinal N-methyl-d-aspartate receptor involvement in prolonged chemical nociception in the rat.
Topics: Animals; Central Nervous System Sensitization; Formaldehyde; Neuronal Plasticity; Nociception; Pain; | 2016 |
Chronic intrathecal cannulas inhibit some and potentiate other behaviors elicited by formalin injection.
Topics: Animals; Behavior, Animal; Drug Administration Routes; Formaldehyde; Humans; Injections, Spinal; MED | 2003 |
Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Formaldehyde; Humans; Pain; Pain Measurement; Posteri | 2005 |
Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Formaldehyde; Humans; Pain; Pain Measurement; Posteri | 2005 |
Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Formaldehyde; Humans; Pain; Pain Measurement; Posteri | 2005 |
Review of a proposed mechanism for the antinociceptive action of botulinum toxin type A.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Formaldehyde; Humans; Pain; Pain Measurement; Posteri | 2005 |
[Experimental methods in pain using neuropathic and inflammatory animal models].
Topics: Animals; Diagnostic Techniques, Neurological; Disease Models, Animal; Formaldehyde; Hot Temperature; | 2007 |
Deafferentation in animals as a model for the study of pain: an alternative hypothesis.
Topics: Afferent Pathways; Animals; Capsaicin; Denervation; Disease Models, Animal; Formaldehyde; Hydroxydop | 1984 |
Spatial and temporal aspects of spinal cord and brainstem activation in the formalin pain model.
Topics: Animals; Behavior, Animal; Brain Stem; Deoxyglucose; Disease Models, Animal; Formaldehyde; Gene Expr | 1993 |
Some new insights into the effects of opioids in phasic and tonic nociceptive tests.
Topics: Animals; Animals, Newborn; Formaldehyde; Humans; Injections, Spinal; Narcotics; Nervous System; Noci | 1998 |
[Acute pain measurement in animals. Part 1].
Topics: Analgesics; Animals; Formaldehyde; Pain; Pain Measurement; Reaction Time | 2001 |
Electrophysiological approaches to the study of bradykinin and nitric oxide in inflammatory pain.
Topics: Animals; Arginine; Bradykinin; Formaldehyde; Inflammation; Neurons; NG-Nitroarginine Methyl Ester; N | 1992 |
The formalin test: an evaluation of the method.
Topics: Animals; Evaluation Studies as Topic; Formaldehyde; Pain | 1992 |
Opioid and catecholaminergic mechanisms of different types of analgesia.
Topics: Acetates; Acetic Acid; Acupuncture Therapy; Analgesia; Animals; Electric Stimulation; Electroshock; | 1986 |
7 trials available for formaldehyde and Ache
| Article | Year |
|---|---|
Comparative evaluation of the effect of two pulpal medicaments on pain and bleeding status of mandibular molars with irreversible pulpitis post-failure of inferior alveolar nerve block: a double-blind, randomized, clinical trial.
Topics: Anesthetics, Local; Humans; Mandibular Nerve; Nerve Block; Pain; Pulpitis | 2022 |
Effect of morphine and ibuprofen on nociceptive behavior, preening and motor activity following tonic chemical pain in the Japanese quail (Coturnix japonica).
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Coturnix; Fo | 2022 |
Gene silencing of NR2B-containing NMDA receptor by intrathecal injection of short hairpin RNA reduces formalin-induced nociception in C57BL/6 mouse.
Topics: Animals; Disease Models, Animal; Formaldehyde; Gene Expression Regulation; Gene Silencing; Injection | 2013 |
Analgesic effects of intraneural injection of ethyl alcohol or formaldehyde in the palmar digital nerves of horses.
Topics: Analgesia; Analgesics; Animals; Ethanol; Female; Forelimb; Formaldehyde; Hoof and Claw; Horses; Inje | 2014 |
The effect of prilocaine and prilocaine plus meperidine infiltration on the pain during nasal packing removal.
Topics: Adolescent; Adult; Analgesics, Opioid; Device Removal; Drug Combinations; Female; Formaldehyde; Hemo | 2007 |
Options for management of acute pain in the rat.
Topics: Acepromazine; Adjuvants, Anesthesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; B | 1997 |
The effect of pentoxifiline on post-injury hyperalgesia in rats and postoperative pain in patients.
Topics: Adult; Animals; Cholecystectomy; Formaldehyde; Humans; Hyperalgesia; Injections, Intraperitoneal; In | 2000 |
1311 other studies available for formaldehyde and Ache
| Article | Year |
|---|---|
TRPA1 mediates formalin-induced pain.
Topics: Animals; Ankyrins; Calcium Channels; Formaldehyde; Ganglia, Spinal; Humans; Nerve Tissue Proteins; N | 2007 |
An ion channel essential for sensing chemical damage.
Topics: Aldehydes; Animals; Cell Line; Formaldehyde; Humans; Iodoacetamide; Mice; Mice, Knockout; Pain; Pain | 2007 |
Spinal distribution of c-Fos activated neurons expressing enkephalin in acute and chronic pain models.
Topics: Analysis of Variance; Animals; Capsaicin; Disease Models, Animal; Enkephalins; Formaldehyde; Freund' | 2014 |
Possible involvement of histamine, dopamine, and noradrenalin in the periaqueductal gray in electroacupuncture pain relief.
Topics: Animals; Dopamine; Electroacupuncture; Formaldehyde; Histamine; Male; Microdialysis; Neurons; Neurot | 2010 |
Synthesis and Antinociceptive Activity of Newly Modified Amine Analogs of Phencyclidine in Mice.
Topics: Amines; Analgesics; Aniline Compounds; Animals; Benzylamines; Formaldehyde; Mice; Pain; Phencyclidin | 2022 |
Activation of peripheral group III metabotropic glutamate receptors suppressed formalin-induced nociception.
Topics: Animals; Formaldehyde; Nociception; Pain; Rats; Rats, Sprague-Dawley; Receptors, Metabotropic Glutam | 2022 |
Antinociceptive effects of flower extracts and the active fraction from Styrax japonicus.
Topics: Analgesics; Animals; Brain; Carrageenan; Edema; Flowers; Formaldehyde; Hot Temperature; Hypnotics an | 2022 |
Lower Formalin-Induced Pain Responses in Painless Diabetic Neuropathy Rat Correlate with the Reduced Spinal Cord NR2B Subunit of N-Methyl-D-Aspartate Receptor Activation.
Topics: Animals; Diabetes Mellitus; Diabetic Neuropathies; Formaldehyde; Male; Pain; Rats; Rats, Sprague-Daw | 2022 |
Neurokinin receptor mechanisms in forebrain medial septum modulate nociception in the formalin model of inflammatory pain.
Topics: Animals; Disinfectants; Formaldehyde; Hippocampus; Inflammation; Male; Nociception; Pain; Piperidine | 2021 |
Antinociceptive and Anti-inflammatory Effect of Corynoline in Different Nociceptive and Inflammatory Experimental Models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Berberine Alkaloids; Capsaicin; Carrageenan; Cytokine | 2022 |
Nociceptive chemical hypersensitivity in the spinal cord of a rat reserpine-induced fibromyalgia model.
Topics: Animals; Fibromyalgia; Formaldehyde; Nociception; Pain; Proto-Oncogene Proteins c-fos; Rats; Rats, S | 2022 |
Antinociceptive, anti-inflammatory and antioxidant activities of the crude ethanolic extract and alkaloid fraction of Waltheria viscosissima A. St. - Hil. (Malvaceae).
Topics: Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carrageenan; Dexamethasone; | 2022 |
Antinociceptive Actions of Botulinum Toxin A1 on Immunogenic Hypersensitivity in Temporomandibular Joint of Rats.
Topics: Analgesics; Animals; Botulinum Toxins, Type A; Formaldehyde; Pain; Rats; Temporomandibular Joint | 2022 |
Effects of Intra-BLA Administration of PPAR Antagonists on Formalin-Evoked Nociceptive Behaviour, Fear-Conditioned Analgesia, and Conditioned Fear in the Presence or Absence of Nociceptive Tone in Rats.
Topics: Analgesia; Animals; Basolateral Nuclear Complex; Conditioning, Psychological; Fear; Formaldehyde; Ma | 2022 |
Pain Modulation from the Locus Coeruleus in a Model of Hydrocephalus: Searching for Oxidative Stress-Induced Noradrenergic Neuroprotection.
Topics: Animals; Dopamine beta-Hydroxylase; Formaldehyde; Hydrocephalus; Locus Coeruleus; Neuroprotection; N | 2022 |
Adolescent nicotine exposure increases nociceptive behaviors in rat model of formalin test: Involvement of ventrolateral periaqueductal gray neurons.
Topics: Analgesics; Animals; Formaldehyde; Male; Morphine; Neurons; Nicotine; Nociception; Pain; Pain Measur | 2022 |
Emodin Reduces Inflammatory and Nociceptive Responses in Different Pain-and Inflammation-Induced Mouse Models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; E | 2023 |
Antinociceptive Effects and Interaction Mechanisms of Intrathecal Pentazocine and Neostigmine in Two Different Pain Models in Rats.
Topics: Analgesics; Animals; Atropine Derivatives; Clonidine; Formaldehyde; Humans; Hyperalgesia; Naloxone; | 2022 |
Enhancement of behavioral nociceptive responses but not itching responses by viewing mirror images in adult mice.
Topics: Animals; Behavior, Animal; Formaldehyde; Mice; Nociception; Pain; Pruritus | 2022 |
Analgesic effect of gastrin-releasing peptide in the dorsal horn.
Topics: Analgesics; Formaldehyde; Gastrin-Releasing Peptide; Humans; Nerve Fibers, Unmyelinated; Pain; Poste | 2022 |
Modelling migraine-related features in the nitroglycerin animal model: Trigeminal hyperalgesia is associated with affective status and motor behavior.
Topics: Animals; Disease Models, Animal; Formaldehyde; Hyperalgesia; Male; Migraine Disorders; Nitroglycerin | 2022 |
The modulatory role of dopamine receptors within the hippocampal cornu ammonis area 1 in stress-induced analgesia in an animal model of persistent inflammatory pain.
Topics: Analgesia; Animals; Benzazepines; Dimethyl Sulfoxide; Disease Models, Animal; Dopamine Antagonists; | 2022 |
Long-term follow-up of intracerebroventricular injection of streptozotocin-inducing pain sensitization.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Follow-Up Studies; Formaldehyde; Pain; Rats; Str | 2022 |
Systemic administration of dorsomorphin relieves inflammatory nociception in the mouse formalin test.
Topics: Analgesics; Animals; Cytokines; Formaldehyde; Mice; Nociception; Pain; Pain Measurement | 2022 |
Chemical characterization, anti-nociceptive and anti-inflammatory activities of Plukenetia conophora seed oil in experimental rodent models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Edema; Formaldehyde; Pain; Pl | 2023 |
Chemical characterization, anti-nociceptive and anti-inflammatory activities of Plukenetia conophora seed oil in experimental rodent models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Edema; Formaldehyde; Pain; Pl | 2023 |
Chemical characterization, anti-nociceptive and anti-inflammatory activities of Plukenetia conophora seed oil in experimental rodent models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Edema; Formaldehyde; Pain; Pl | 2023 |
Chemical characterization, anti-nociceptive and anti-inflammatory activities of Plukenetia conophora seed oil in experimental rodent models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Edema; Formaldehyde; Pain; Pl | 2023 |
Antinociceptive effect and identification of berberine alkaloid in Berberis ruscifolia extracts.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Berberine; Berberis; Edema; Ethanol; Formaldehyde; Mice | 2023 |
Antinociceptive effects of nortriptyline and desipramine hydrochloride in Speke's hinge-back tortoise (Kinixys Spekii).
Topics: Analgesics; Animals; Capsaicin; Desipramine; Formaldehyde; Nortriptyline; Pain; Turtles | 2023 |
Pramipexole inhibits formalin-induce acute and long-lasting mechanical hypersensitivity via NF-kB pathway in rats.
Topics: Animals; Formaldehyde; Hyperalgesia; NF-kappa B; Pain; Pramipexole; Quality of Life; Rats; Rats, Wis | 2023 |
The stress-induced antinociceptive responses to the persistent inflammatory pain involve the orexin receptors in the nucleus accumbens.
Topics: Analgesics; Animals; Formaldehyde; Male; Nucleus Accumbens; Orexin Receptor Antagonists; Orexin Rece | 2023 |
Restraint stress induced the antinociceptive responses via the dopamine receptors within the hippocampal CA1 area in animal model of persistent inflammatory pain.
Topics: Analgesics; Animals; Benzazepines; Formaldehyde; Hippocampus; Male; Models, Animal; Pain; Rats; Rats | 2023 |
Epidural Administration of Curcumin-Loaded Polycaprolactone/Gelatin Electrospun Nanofibers for Extended Analgesia After Laminectomy in Rats.
Topics: Analgesia; Analgesics; Animals; Curcumin; Delayed-Action Preparations; Formaldehyde; Gelatin; Lamine | 2023 |
Histamine and its H 1 receptors in the ventral pallidum mediate formalin-induced pain-related behaviors through this region and spinal cord opioid receptors.
Topics: Animals; Basal Forebrain; Formaldehyde; Histamine; Histamine Agonists; Naloxone; Pain; Receptors, Op | 2023 |
UHPLC-MS and GC-MS phytochemical profiling, amelioration of pain and inflammation with chloroform extract of Funaria hygrometrica Hedw. via modulation of inflammatory biomarkers.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Chloroform; Chromatography, High Pressur | 2023 |
The role of the male rat infralimbic cortex in distraction analgesia.
Topics: Analgesia; Animals; Formaldehyde; Male; Pain; Pain Management; Pain Measurement; Rats | 2023 |
Curcuma latifolia Roscoe extract reverses inflammatory pain in mice and offers a favorable CNS safety profile.
Topics: Analgesics; Animals; Central Nervous System; Curcuma; Female; Formaldehyde; Mice; Pain; Plant Extrac | 2024 |
Development and evaluation of a Chinese herbal gel for analgesic and anti-inflammatory effects.
Topics: Analgesics; Animals; Arthritis, Rheumatoid; Formaldehyde; Gels; Pain; Rats | 2023 |
Dehydroepiandrosterone Sulfate (DHEAS) Is an Endogenous Kv7 Channel Modulator That Reduces Kv7/M-Current Suppression and Inflammatory Pain.
Topics: Animals; Dehydroepiandrosterone Sulfate; Female; Formaldehyde; KCNQ2 Potassium Channel; KCNQ3 Potass | 2023 |
Cold pressed Pinus halepensis Mill. seed oil for potential health applications: Analgesic, anti-inflammatory effects, and assessment of inflammatory mediators by RT-qPCR in skin wound healing.
Topics: Analgesics; Anti-Inflammatory Agents; Carrageenan; Edema; Formaldehyde; Inflammation Mediators; Pain | 2024 |
Exploring the therapeutic potential of Prinsepia utilis Royle seed oil: A comprehensive study on chemical composition, physicochemical properties, anti-inflammatory, and analgesic activities.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Formaldehyde; Gas Chromatography- | 2024 |
Topics: Analgesics; Animals; Disease Models, Animal; Ethanol; Fallopia japonica; Formaldehyde; Inflammation; | 2023 |
Design, synthesis and molecular docking of benzophenone conjugated with oxadiazole sulphur bridge pyrazole pharmacophores as anti inflammatory and analgesic agents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Cyclooxyge | 2019 |
Involvement of serotonergic and opioidergic systems in the antinociceptive effect of ketamine-magnesium sulphate combination in formalin test in rats.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Therapy, Combination; Formaldehyde; Keta | 2019 |
Chemical composition and evaluation of the antinociceptive, antioxidant and antimicrobial effects of essential oil from Hymenaea cangaceira (Pinto, Mansano & Azevedo) native to Brazil: A natural medicine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Bacterial Agents; Antioxidants; Brazil; Disease Models, Anima | 2020 |
New Amine and Aromatic Substituted Analogues of Phencyclidine: Synthesis and Determination of Acute and Chronic Pain Activities.
Topics: Amines; Animals; Formaldehyde; High-Throughput Screening Assays; Male; Mice; Mice, Inbred Strains; M | 2019 |
Zinc oxide nanoparticles synthesized from Fraxinus rhynchophylla extract by green route method attenuates the chemical and heat induced neurogenic and inflammatory pain models in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Fraxinus; Green Chemistry Technology; Hot | 2020 |
Analgesic Effect of Intrathecal Melissa officinalis in the Rat Model of Hot-Water and Formalin-Induced Pain.
Topics: Analgesics; Animals; Formaldehyde; Humans; Injections, Spinal; Male; Melissa; Pain; Pain Management; | 2020 |
Pharmacological evaluation underlying the antinociceptive activity of two new hybrids NSAIDs tetrahydropyran derivatives.
Topics: Adenosine Triphosphate; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Stero | 2020 |
Anti-Nociceptive and Anti-Inflammation Effect Mechanisms of Mutants of Syb-prII, a Recombinant Neurotoxic Polypeptide.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Edema; Female; Formaldehyde; Ganglia, Spinal; Mice; M | 2019 |
NADPH oxidase1 inhibition leads to regression of central sensitization during formalin induced acute nociception via attenuation of ERK1/2-NFκB signaling and glial activation.
Topics: Animals; Astrocytes; Central Nervous System Sensitization; Formaldehyde; Male; Mice; NADP; NADPH Oxi | 2020 |
Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Female; Formaldehyde; gamma-Aminobutyric Acid | 2020 |
Effect of spinal angiotensin-converting enzyme 2 activation on the formalin-induced nociceptive response in mice.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Diminazene; Disease Models, | 2020 |
Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Formaldehyde; Humans; Inda | 2020 |
Pharmacological characterization of a novel, potent, selective, and orally active fatty acid amide hydrolase inhibitor, PKM-833 [(R)-N-(pyridazin-3-yl)-4-(7-(trifluoromethyl)chroman-4-yl)piperazine-1-carboxamide] in rats: Potential for the treatment of in
Topics: Administration, Oral; Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents; Brain; Cell Li | 2020 |
Ethenzamide Exerts Analgesic Effect at the Spinal Cord via Multiple Mechanisms of Action Including the 5HT
Topics: Analgesics; Animals; CHO Cells; Cricetulus; Formaldehyde; HEK293 Cells; HeLa Cells; Humans; Male; Pa | 2020 |
Design, synthesis, and biological activity of new endomorphin analogs with multi-site modifications.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Design; Formaldehyde; Male; Mice | 2020 |
Mechanical allodynia in mice with tenascin-X deficiency associated with Ehlers-Danlos syndrome.
Topics: Analgesics; Animals; Ehlers-Danlos Syndrome; Formaldehyde; Hyperalgesia; Male; Mice, Inbred C57BL; P | 2020 |
Vitamin D (VD3) antioxidative and anti-inflammatory activities: Peripheral and central effects.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Brain; Carrageenan; Cyclooxygenase 2; Edema; Formal | 2020 |
Antinociceptive effects of ceftriaxone in formalin-induced nociception.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Ceftriaxone; Drug Administration Schedule; Female; Forma | 2020 |
Spinal administration of the multi-functional opioid/neuropeptide FF agonist BN-9 produced potent antinociception without development of tolerance and opioid-induced hyperalgesia.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Drug Tolerance; Fascia; Formaldehyde; Hot Temperature; Hyp | 2020 |
Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord.
Topics: Animals; Formaldehyde; Glutamic Acid; Male; Nefopam; Norepinephrine; Pain; Serotonin; Serotonin Anta | 2020 |
Analgesic action of Rubimaillin in vitro and in vivo.
Topics: Acetic Acid; Analgesics; Animals; Cyclic AMP; Cyclooxygenase 2; Dinoprostone; Formaldehyde; Lipopoly | 2020 |
Antinociceptive Effects of VV-Hemorphin-5 Peptide Analogues Containing Amino phosphonate Moiety in Mouse Formalin Model of Pain.
Topics: Analgesics; Animals; Formaldehyde; Hemoglobins; Male; Mice; Mice, Inbred ICR; Pain; Peptide Fragment | 2021 |
Evaluation of anti-inflammatory and analgesic activities of aqueous methanolic extract of Ranunculus muricatus in albino mice.
Topics: Acetic Acid; Albumins; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, A | 2020 |
The modulatory role of β‑amyloid in the regulation of nociception in mice.
Topics: Amyloid beta-Peptides; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Injections, | 2020 |
The anti-inflammatory and analgesic activities of the ethyl acetate extract of Viburnum taitoense Hayata.
Topics: Acetates; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; China; Cytok | 2021 |
Active components of Bupleurum chinense and Angelica biserrata showed analgesic effects in formalin induced pain by acting on Nav1.7.
Topics: Analgesics; Angelica; Animals; Bupleurum; CHO Cells; Cricetulus; Disease Models, Animal; Drugs, Chin | 2021 |
Design, Synthesis and Biological Activity of New Amides Derived from 3-Benzhydryl and 3-sec-Butyl-2,5-dioxo-pyrrolidin-1-yl-acetic Acid.
Topics: Acetic Acid; Amides; Analgesics; Antineoplastic Agents; Cell Proliferation; Dose-Response Relationsh | 2021 |
Bupleurum falcatum L. alleviates nociceptive and neuropathic pain: Potential mechanisms of action.
Topics: Animals; Arginine; Bupleurum; Cyclic GMP; Formaldehyde; Hyperalgesia; Iran; Male; Medicine, Traditio | 2021 |
Comparison of analgesic activities of aconitine in different mice pain models.
Topics: Acetic Acid; Aconitine; Analgesics; Animals; Aspirin; Disease Models, Animal; Edema; Female; Formald | 2021 |
NFAT5 Deficiency Alleviates Formalin-Induced Inflammatory Pain Through mTOR.
Topics: Animals; Cell Line, Tumor; Formaldehyde; Inflammation; Male; Mice; Mice, Inbred C57BL; Neurons; Pain | 2021 |
Effects of Spirulina platensis on pain and inflammation in long Evans rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Diclofenac; Disease Models, Animal; Female; Formaldeh | 2020 |
Analgesic effect of voluntary exercise in a rat model of persistent pain via suppression of microglial activation in the spinal cord.
Topics: Analgesics; Animals; Brain-Derived Neurotrophic Factor; Cell Proliferation; Chronic Pain; Disease Mo | 2021 |
Pharmacological studies on aqueous extract of Launaea arborescens from southwest Algeria.
Topics: Algeria; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Behavior, Animal; Capsaicin; Ede | 2021 |
The effective interplay of (non-) selective NSAIDs with neostigmine in animal models of analgesia and inflammation.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Dic | 2021 |
Central and peripheral pain intervention by Ophiorrhizarugosa leaves: Potential underlying mechanisms and insight into the role of pain modulators.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Central N | 2021 |
Cannabidiol microinjection into the nucleus accumbens attenuated nociceptive behaviors in an animal model of tonic pain.
Topics: Animals; Cannabidiol; Disease Models, Animal; Formaldehyde; Male; Microinjections; Nociception; Nucl | 2021 |
Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels.
Topics: Analgesics; Animals; Berberine Alkaloids; CHO Cells; Corydalis; Cricetulus; Disease Models, Animal; | 2021 |
Allium macrostemon Bunge. exerts analgesic activity by inhibiting NaV1.7 channel.
Topics: Acetic Acid; Analgesics; Animals; Cell Survival; Chive; Formaldehyde; Ganglia, Spinal; HEK293 Cells; | 2021 |
A role for the locus coeruleus in the analgesic efficacy of N-acetylaspartylglutamate peptidase (GCPII) inhibitors ZJ43 and 2-PMPA.
Topics: Analgesics; Animals; Disease Models, Animal; Dopamine beta-Hydroxylase; Excitatory Amino Acid Agents | 2017 |
The Effects of Different Intensities of Exercise on Behavioral and Molecular Pain-Related Reactions in Rats: Implications for Medication Development.
Topics: Animals; Behavior, Animal; Female; Formaldehyde; Immunohistochemistry; Pain; Physical Conditioning, | 2017 |
A Novel Brucine Gel Transdermal Delivery System Designed for Anti-Inflammatory and Analgesic Activities.
Topics: Administration, Cutaneous; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; C | 2017 |
Mapping of pain circuitry in early post-natal development using manganese-enhanced MRI in rats.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Brain Mapping; Chlorides; Disease Models, Animal; Fem | 2017 |
Long-term anti-itch effect of botulinum neurotoxin A is associated with downregulation of TRPV1 and TRPA1 in the dorsal root ganglia in mice.
Topics: Acetone; Animals; Botulinum Toxins, Type A; Chloroquine; Chronic Disease; Disease Models, Animal; Do | 2017 |
Systemic and local anti-nociceptive effects of simvastatin in the rat formalin assay: Role of peroxisome proliferator-activated receptor γ and nitric oxide.
Topics: Animals; Formaldehyde; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Irritants; Male; Nitric Oxide | 2017 |
Variations of isovaline structure related to activity in the formalin foot assay in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Female; Formaldehyde; Mice; Pain; Valine | 2017 |
Dexmedetomidine relieves formaldehyde-induced pain in rats through both α2 adrenoceptor and imidazoline receptor.
Topics: Animals; Dexmedetomidine; Formaldehyde; Imidazoline Receptors; Male; Nitric Oxide Synthase Type I; P | 2017 |
Hydro-ethanolic leaf extract of Ziziphus abyssinica Hochst Ex A. Rich (Rhamnaceae) exhibits anti-nociceptive effects in murine models.
Topics: Acetic Acid; Africa; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; D | 2017 |
Benzoxazolinone aryl sulfonamides as potent, selective Na
Topics: Administration, Oral; Analgesics; Animals; Benzoxazoles; Biological Availability; Disease Models, An | 2017 |
The Analgesic Effects of Celecoxib on the Formalin-induced Short- and Long-term Inflammatory Pain.
Topics: Analgesics; Animals; Celecoxib; Dose-Response Relationship, Drug; Formaldehyde; Hyperalgesia; Male; | 2017 |
Report: Analgesic and anti-inflammatory activity of aqueous-methanolic extract of Aerva javanica.
Topics: Acetic Acid; Amaranthaceae; Analgesics; Animals; Anti-Inflammatory Agents; Chondrus; Disease Models, | 2017 |
Sinomenine produces peripheral analgesic effects via inhibition of voltage-gated sodium currents.
Topics: Animals; Antirheumatic Agents; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, | 2017 |
Activation of P2X3 receptors in the cerebrospinal fluid-contacting nucleus neurons reduces formalin-induced pain behavior via PAG in a rat model.
Topics: Adenosine Triphosphate; Animals; Cerebrospinal Fluid; Cholera Toxin; Disease Models, Animal; Disinfe | 2017 |
Additive and antagonistic antinociceptive interactions between magnesium sulfate and ketamine in the rat formalin test.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Ketamine; Magnesium Sulfate; Ma | 2017 |
Experiencing early life maternal separation increases pain sensitivity in adult offspring.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Female; | 2017 |
Discovery of orally bioavailable cyclohexanol-based NR2B-selective NMDA receptor antagonists with analgesic activity utilizing a scaffold hopping approach.
Topics: Administration, Oral; Analgesics; Animals; Brain; Cyclohexanols; Dose-Response Relationship, Drug; D | 2017 |
[Spinal analgesic mechanism of minocycline in formalin-induced inflammatory pain].
Topics: Analgesics; Animals; Formaldehyde; Male; Minocycline; Pain; Patch-Clamp Techniques; Rats; Rats, Spra | 2017 |
Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.
Topics: Adrenergic Antagonists; Animals; Calcitonin Gene-Related Peptide; Calcitonin Receptor-Like Protein; | 2017 |
Enhanced Activities of δ Subunit-containing GABA
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; GABA-A Receptor Agonists; Isoxazoles; Long- | 2018 |
Antinociception of the spirocyclopiperazinium salt compound LXM-15 via activating α7 nAChR and M4 mAChR and inhibiting CaMKIIα/cAMP/CREB/CGRP signalling pathway in mice.
Topics: Acetic Acid; alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Calcitonin Gene-Related P | 2018 |
Antinociceptive profiles and mechanisms of centrally administered oxyntomodulin in various mouse pain models.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cytokines; Disease Models, Animal; Formaldehyde; | 2018 |
Antinociceptive effects of novel epibatidine analogs through activation of α4β2 nicotinic receptors.
Topics: Analgesics, Non-Narcotic; Animals; Binding, Competitive; Bridged Bicyclo Compounds, Heterocyclic; Co | 2018 |
Sex differences in antinociceptive response to Δ-9-tetrahydrocannabinol and CP 55,940 in the mouse formalin test.
Topics: Analgesics; Analysis of Variance; Animals; Cyclohexanols; Disease Models, Animal; Dose-Response Rela | 2018 |
The efficacy of a lectin from Abelmoschus Esculentus depends on central opioid receptor activation to reduce temporomandibular joint hypernociception in rats.
Topics: Abelmoschus; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Formaldehyde; Inflam | 2018 |
A Neural Circuit for the Suppression of Pain by a Competing Need State.
Topics: Agouti-Related Protein; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavi | 2018 |
Saline extract of Pilosocereus gounellei stem has antinociceptive effect in mice without showing acute toxicity and altering motor coordination.
Topics: Acetic Acid; Analgesics; Animals; Artemia; Cactaceae; Cholesterol; Female; Formaldehyde; Hot Tempera | 2018 |
Inhibition of Neuroinflammation by AIBP: Spinal Effects upon Facilitated Pain States.
Topics: Animals; Carrier Proteins; Cholesterol; Cisplatin; Cytokines; Formaldehyde; Hyperalgesia; Inflammati | 2018 |
New
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Coffee; Disease Models, Animal; Female; Formaldehy | 2018 |
Effects of isopulegol in acute nociception in mice: Possible involvement of muscarinic receptors, opioid system and l-arginine/NO/cGMP pathway.
Topics: Acute Disease; Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Capsaicin; Cyc | 2018 |
Involvement of glutamate receptors of the paragigantocellularis lateralis nucleus in the pain modulatory effect of 17β-estradiol in male rats.
Topics: Animals; Estradiol; Formaldehyde; Irritants; Male; Medulla Oblongata; Pain; Pain Measurement; Rats; | 2020 |
Anti-inflammatory and antinociceptive activities of the leaf methanol extract of Miconia minutiflora (Bonpl.) DC. and characterization of compounds by UPLC-DAD-QTOF-MS/MS.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Chr | 2019 |
[Minocycline inhibits formalin-induced inflammatory pain and the underlying mechanism].
Topics: Animals; Anti-Bacterial Agents; Formaldehyde; Inflammation; Inhibitory Postsynaptic Potentials; Male | 2018 |
Sida tuberculata extract reduces the nociceptive response by chemical noxious stimuli in mice: Implications for mechanism of action, relation to chemical composition and molecular docking.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Brazil; Formaldehyde; Male; Malvaceae; Methanol; | 2019 |
Eslicarbazepine acetate reduces trigeminal nociception: Possible role of adrenergic, cholinergic and opioid receptors.
Topics: Adrenergic Antagonists; Analgesics; Animals; Atropine; Cholinergic Antagonists; Dibenzazepines; Form | 2018 |
Effects of glial glutamate transporter activator in formalin-induced pain behaviour in mice.
Topics: Animals; Astrocytes; Behavior, Animal; Excitatory Amino Acid Transporter 2; Extracellular Signal-Reg | 2019 |
The novel small-molecule antagonist of PAC1 receptor attenuates formalin-induced inflammatory pain behaviors in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Formaldehyde; Injections, Spinal; M | 2019 |
Analgesic and anti-edemic properties of etifoxine in models of inflammatory sensitization.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Edema; Formaldeh | 2019 |
Comparison of antinociceptive effects of plain lidocaine versus lidocaine complexed with hydroxypropyl-β-cyclodextrin in animal models of acute and persistent orofacial pain.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Analgesics; Animals; Capsaicin; Carrageenan; Disease Models, Anim | 2019 |
Conditioned pain modulation in rodents can feature hyperalgesia or hypoalgesia depending on test stimulus intensity.
Topics: Acetic Acid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Facial Pain; Formald | 2019 |
Acute Administration of Desformylflustrabromine Relieves Chemically Induced Pain in CD-1 Mice.
Topics: Acetic Acid; Allosteric Regulation; Analgesics; Animals; Formaldehyde; Hydrocarbons, Brominated; Ind | 2019 |
Evidence for antinociceptive effects of combined administration of vitamin E and celecoxib in tail-flick and formalin test in male rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Formaldehyde; Indomethacin; | 2019 |
Anti-inflammatory and antinociceptive effects of active ingredients in the essential oils from Gynura procumbens, a traditional medicine and a new and popular food material.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Cell Movement; Edema; Food; Formaldehyde; | 2019 |
Opioid-sparing effects of cannabinoids on morphine analgesia: participation of CB
Topics: Analgesics, Opioid; Animals; Cannabinoids; Carrageenan; Dose-Response Relationship, Drug; Formaldehy | 2019 |
Chemical Synthesis, Proper Folding, Na
Topics: Amino Acid Sequence; Analgesics; Animals; CHO Cells; Cricetulus; Female; Formaldehyde; Mice, Inbred | 2019 |
Long-term imaging of dorsal root ganglia in awake behaving mice.
Topics: Animals; Behavior Observation Techniques; Behavior, Animal; Calcium; Female; Formaldehyde; Ganglia, | 2019 |
Antipyretic and anti-nociceptive effects of methanol extract of leaves of Fimbristylis miliacea in mice model.
Topics: Acetic Acid; Analgesics; Animals; Antipyretics; Cyperaceae; Disease Models, Animal; Female; Fever; F | 2019 |
Role of DLC2 and RhoA/ROCK pathway in formalin induced inflammatory pain in mice.
Topics: Amides; Animals; Formaldehyde; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Kno | 2019 |
Genetic mapping in Diversity Outbred mice identifies a Trpa1 variant influencing late-phase formalin response.
Topics: Alleles; Animals; Collaborative Cross Mice; Female; Formaldehyde; Genetic Variation; Genotype; Male; | 2019 |
Discovery of Novel Biased Opioid Receptor Ligands through Structure-Based Pharmacophore Virtual Screening and Experiment.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Prec | 2019 |
Impaired behavioural pain responses in hph-1 mice with inherited deficiency in GTP cyclohydrolase 1 in models of inflammatory pain.
Topics: Animals; Behavior, Animal; Biopterins; Biosynthetic Pathways; Capsaicin; Chromatography, High Pressu | 2013 |
The Yin and Yang of pain: variability in formalin test nociception and morphine analgesia produced by the Yin Yang 1 transcription factor gene.
Topics: Analgesia; Analgesics, Opioid; Animals; Cells, Cultured; Formaldehyde; Ganglia, Spinal; Mice; Mice, | 2013 |
The antinociceptive effect of SNAP5114, a gamma-aminobutyric acid transporter-3 inhibitor, in rat experimental pain models.
Topics: Acute Pain; Analgesics; Animals; Anisoles; Behavior, Animal; Chronic Pain; Constriction, Pathologic; | 2013 |
Lysine-specific demethylase 1 in breast cancer cells contributes to the production of endogenous formaldehyde in the metastatic bone cancer pain model of rats.
Topics: Animals; Behavior, Animal; Bone Neoplasms; Breast Neoplasms; Cell Line, Tumor; Disease Models, Anima | 2013 |
Interleukin-33 mediates formalin-induced inflammatory pain in mice.
Topics: Animals; Behavior, Animal; Formaldehyde; Inflammation; Interleukin-1 Receptor-Like 1 Protein; Interl | 2013 |
Antinociceptive, neurobehavioral and antioxidant effects of Eupatorium triplinerve Vahl on rats.
Topics: Analgesics; Animals; Anti-Anxiety Agents; Antidepressive Agents; Antioxidants; Behavior, Animal; Eup | 2013 |
Activity of nicorandil, a nicotinamide derivative with a nitrate group, in the experimental model of pain induced by formaldehyde in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Glyburi | 2013 |
Anti-nociceptive and anti-allodynic activity of aliskiren in various pain models.
Topics: Acetic Acid; Amides; Analgesics; Animals; Behavior, Animal; Capsaicin; Female; Formaldehyde; Fumarat | 2013 |
Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats.
Topics: Action Potentials; Affective Symptoms; Analysis of Variance; Aniline Compounds; Animals; Arginine; C | 2013 |
Systemic synergism between codeine and morphine in three pain models in mice.
Topics: Acetic Acid; Acute Pain; Analgesics, Opioid; Animals; Behavior, Animal; Codeine; Disease Models, Ani | 2013 |
Anti-inflammatory and analgesic activities of Melanthera scandens.
Topics: Acetic Acid; Albumins; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Carrageenan; Edema | 2012 |
Valproic acid: an anticonvulsant drug with potent antinociceptive and anti-inflammatory properties.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anticonvulsants; Butyric Acid; Carrageenan; Drug Syne | 2013 |
Antihyperalgesic activity of a novel synthesized analogue of lidocaine in diabetic rats.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Diabetes Complications; | 2013 |
Histamine produces opposing effects to serotonin in the knee joint of rats.
Topics: Analysis of Variance; Animals; Cetirizine; Edema; Evans Blue; Formaldehyde; Histamine; Histamine H1 | 2013 |
[The role of HO/CO in the spinal nociception transmission and hyperalgesia of rats induced by formalin].
Topics: Animals; Carbon Monoxide; Formaldehyde; Heme Oxygenase (Decyclizing); Hemin; Hyperalgesia; Male; Noc | 2013 |
Antinociceptive activity of Rhoifoline A from the ethanol extract of Zanthoxylum nitidum in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Benzophenanthridines; Depression; Ethanol; Explo | 2013 |
Antinociceptive profiles and mechanisms of orally administered coumarin in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Coumarins; Formaldehyde; G | 2013 |
Topical anti-inflammatory and analgesic activities of standardized pomegranate rind extract in comparison with its marker compound ellagic acid in vivo.
Topics: Administration, Topical; Analgesics; Animals; Ankle Joint; Anti-Inflammatory Agents; Arthritis; Carr | 2013 |
Different peripheral tissue injury induces differential phenotypic changes of spinal activated microglia.
Topics: Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Calcium-Binding Proteins; CD11b An | 2013 |
Diphenyl diselenide reduces mechanical and thermal nociceptive behavioral responses after unilateral intrastriatal administration of 6-hydroxydopamine in rats.
Topics: Administration, Oral; Animals; Benzene Derivatives; Corpus Striatum; Formaldehyde; Hot Temperature; | 2013 |
Anti-inflammatory and antinociceptive effects of hydroalcoholic extract from Pseudobombax marginatum inner bark from caatinga potiguar.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Ethanol; Formaldehyd | 2013 |
Bioassay-guided evaluation of Dioscorea villosa - an acute and subchronic toxicity, antinociceptive and anti-inflammatory approach.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Biological Assay; | 2013 |
Synergistic interactions between the antinociceptive effect of Rhodiola rosea extract and B vitamins in the mouse formalin test.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Female; Fo | 2013 |
Reversible inhibition of the glycine transporter GlyT2 circumvents acute toxicity while preserving efficacy in the treatment of pain.
Topics: Analgesics; Animals; Benzamides; Blood-Brain Barrier; Brain; Capillary Permeability; Cell Line; Dise | 2013 |
Analgesic and antipyretic activities of Drymaria cordata (Linn.) Willd (Caryophyllaceae) extract.
Topics: 2,4-Dinitrophenol; Acetic Acid; Analgesics; Animals; Antipyretics; Body Temperature; Caryophyllaceae | 2012 |
Anti-inflammatory and anti-ulcerogenic activities of Chantaleela recipe.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Antipyretics; Carrageenan; Dinopro | 2012 |
Fucomannogalactan and glucan from mushroom Amanita muscaria: structure and inflammatory pain inhibition.
Topics: Amanita; Animals; Female; Formaldehyde; Fruiting Bodies, Fungal; Galactans; Glucans; Inflammation; M | 2013 |
Bioguided isolation of myricetin-3-O-β-galactopyranoside with antinociceptive activity from the aerial part of Davilla elliptica St.-Hil.
Topics: Analgesics; Animals; Dilleniaceae; Flavonoids; Formaldehyde; Galactosides; Male; Mice; Pain; Phytoth | 2013 |
Antinociceptive activity of cyclopeptide alkaloids isolated from Ziziphus oxyphylla Edgew (Rhamnaceae).
Topics: Abdomen; Acetic Acid; Alkaloids; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Form | 2013 |
Anti-inflammatory and antinociceptive activity of chitin-binding lectin from Canna limbata seeds.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Chitin; Formaldehyde; Hemagglutination; Humans; Infla | 2013 |
Antinociceptive effect of intracerebroventricular administration of D-serine on formalin-induced pain.
Topics: Analgesics; Animals; Formaldehyde; Infusions, Intraventricular; Male; Pain; Pain Measurement; Quinol | 2014 |
Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antiviral Agents; Chlorocebus aethiops; | 2013 |
Antinociceptive effects of ethanolic extract from the flowers of Acmella oleracea (L.) R.K. Jansen in mice.
Topics: Acrolein; Analgesics; Animals; Asteraceae; Capsaicin; Ethanol; Flowers; Formaldehyde; Hot Temperatur | 2013 |
Comparison of active constituents, acute toxicity, anti-nociceptive and anti-inflammatory activities of Porana sinensis Hemsl., Erycibe obtusifolia Benth. and Erycibe schmidtii Craib.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Convolvulaceae; Ear; Edema; | 2013 |
Semi-mechanistic modelling of the analgesic effect of gabapentin in the formalin-induced rat model of experimental pain.
Topics: Amines; Analgesics; Animals; Computer Simulation; Cyclohexanecarboxylic Acids; Dose-Response Relatio | 2014 |
Different role of spinal 5-HT(hydroxytryptamine)7 receptors and descending serotonergic modulation in inflammatory pain induced in formalin and carrageenan rat models.
Topics: Animals; Carrageenan; Disease Models, Animal; Formaldehyde; Hyperalgesia; Inflammation; Male; Pain; | 2014 |
Evaluation of the antinociceptive and anti-inflammatory effect of Caralluma dalzielii.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Apocynaceae; Formaldehyde; Hot Temperatu | 2013 |
Evaluation of anti-inflammatory and antinociceptive activity of Triphala recipe.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Carrageenan; Chronic Disease; Ear; | 2013 |
Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin.
Topics: Action Potentials; Amino Acid Sequence; Animals; Arvicolinae; Food Chain; Formaldehyde; Mice; Molecu | 2013 |
Effects of Papaver rhoeas (L.) extract on formalin-induced pain and inflammation in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Corticosterone; Disease Models, Animal; Dose-Response | 2012 |
The dominant/subordinate relationship between mice modifies the approach behavior toward a cage mate experiencing pain.
Topics: Animals; Behavior, Animal; Competitive Behavior; Dominance-Subordination; Feeding Behavior; Formalde | 2014 |
Involvement of dopamine receptors within the dorsal hippocampus in suppression of the formalin-induced orofacial pain.
Topics: Animals; CA1 Region, Hippocampal; Formaldehyde; Male; Mouth; Pain; Rats; Rats, Wistar; Receptors, Do | 2013 |
Antinociceptive effects of analgesic-antitumor peptide (AGAP), a neurotoxin from the scorpion Buthus martensii Karsch, on formalin-induced inflammatory pain through a mitogen-activated protein kinases-dependent mechanism in mice.
Topics: Analgesics; Animals; Antineoplastic Agents; Arthropod Proteins; Disinfectants; Dose-Response Relatio | 2013 |
Effects of dominant/subordinate social status on formalin-induced pain and changes in serum proinflammatory cytokine concentrations in mice.
Topics: Animals; Body Weight; Corticosterone; Disease Models, Animal; Dominance-Subordination; Formaldehyde; | 2013 |
Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain.
Topics: Animals; Formaldehyde; Freund's Adjuvant; Hindlimb; Hyperalgesia; Inflammation; Lumbosacral Region; | 2014 |
A role for PPARα in the medial prefrontal cortex in formalin-evoked nociceptive responding in rats.
Topics: Animals; Formaldehyde; Male; Pain; PPAR alpha; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Revers | 2014 |
Possible mechanism involved in the antinociceptive activity of dimer of paederosidic acid and paederosidic acid methyl ester in mice.
Topics: Analgesics; Analysis of Variance; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2014 |
Association of antinociceptive action of botulinum toxin type A with GABA-A receptor.
Topics: Animals; Bicuculline; Botulinum Toxins, Type A; Disease Models, Animal; Drug Administration Routes; | 2014 |
Anti-inflammatory and antinociceptive effects of Sterculia striata A. St.-Hil. & Naudin (Malvaceae) in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Dextrans; Edema; | 2014 |
Antinociceptive and anti-inflammatory effects of flavonoids PMT1 and PMT2 isolated from Piper montealegreanum Yuncker (Piperaceae) in mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Disease Models, Animal; Edema; Flavonoids; | 2014 |
Antinociceptive esters of N-methylanthranilic acid: Mechanism of action in heat-mediated pain.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dose-Response Relationship | 2014 |
Antinociceptive effect of certain dimethoxy flavones in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationsh | 2014 |
ERK MAP kinase activation in spinal cord regulates phosphorylation of Cdk5 at serine 159 and contributes to peripheral inflammation induced pain/hypersensitivity.
Topics: Animals; Butadienes; Cyclin-Dependent Kinase 5; Enzyme Activation; Fixatives; Formaldehyde; Hyperalg | 2014 |
Hydroalcoholic extract of Rosemary (Rosmarinus officinalis L.) and its constituent carnosol inhibit formalin-induced pain and inflammation in mice.
Topics: Abietanes; Alcohols; Analgesics; Animals; Anti-Inflammatory Agents; Corticosterone; Cyclooxygenase 1 | 2013 |
The antinociceptive effect of dexmedetomidine modulates spleen cell immunity in mice.
Topics: Analgesics; Animals; Dexmedetomidine; Formaldehyde; Immunity; Interleukin-10; Killer Cells, Natural; | 2014 |
Study on analgesic and anti-inflammatory properties of Cordia myxa fruit hydro-alcoholic extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Cordia; Disease Models | 2013 |
From peripheral to central: the role of ERK signaling pathway in acupuncture analgesia.
Topics: Acupuncture Analgesia; Animals; Blotting, Western; Butadienes; Disease Models, Animal; Enzyme Inhibi | 2014 |
Contribution of anterior cingulate cortex and descending pain inhibitory system to analgesic effect of lemon odor in mice.
Topics: Administration, Inhalation; Affect; Animals; Aromatherapy; Benzazepines; Disease Models, Animal; Dop | 2014 |
Activation of peripheral KCNQ channels attenuates inflammatory pain.
Topics: Animals; Anthracenes; Anticonvulsants; Benzamides; Carbamates; Disease Models, Animal; Electric Stim | 2014 |
Sulfated polysaccharides isolated from the green seaweed Caulerpa racemosa plays antinociceptive and anti-inflammatory activities in a way dependent on HO-1 pathway activation.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Caulerpa; Dextrans; Edema; | 2014 |
Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica.
Topics: Acetic Acid; Anacardiaceae; Analgesics; Animals; Cyclic GMP; Ethanol; Female; Formaldehyde; Glutamic | 2014 |
Chemical composition and antinociceptive effect of aqueous extract from Rourea induta Planch. leaves in acute and chronic pain models.
Topics: Analgesics; Animals; Connaraceae; Female; Formaldehyde; Freund's Adjuvant; Interleukin-1beta; Male; | 2014 |
Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1.
Topics: Animals; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; HEK293 Cells; Humans; Membrane Glyco | 2014 |
Inactivation of the prelimbic rather than infralimbic cortex impairs acquisition and expression of formalin-induced conditioned place avoidance.
Topics: Animals; Avoidance Learning; Conditioning, Classical; Formaldehyde; GABA-A Receptor Agonists; Male; | 2014 |
Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants.
Topics: Animals; Azetidines; Benzylamines; Bradykinin; Cell Line; Female; Foot; Formaldehyde; Inflammation; | 2014 |
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
Topics: Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Form | 2014 |
Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dioxoles; Edema; Formaldehy | 2014 |
Peripheral synergism between tramadol and ibuprofen in the formalin test.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Combinations; Drug Synergism; Formaldehy | 2014 |
The methanol extract of Euonymus laxiflorus, Rubia lanceolata and Gardenia jasminoides inhibits xanthine oxidase and reduce serum uric acid level in rats.
Topics: Animals; Disease Models, Animal; Euonymus; Formaldehyde; Gardenia; Gout; Hyperuricemia; Nociception; | 2014 |
Syntaxin 8 modulates the post-synthetic trafficking of the TrkA receptor and inflammatory pain transmission.
Topics: Animals; Fixatives; Formaldehyde; Ganglia, Spinal; Gene Knockdown Techniques; HEK293 Cells; Humans; | 2014 |
Inhibition of peripheral anion exchanger 3 decreases formalin-induced pain.
Topics: Animals; Chloride-Bicarbonate Antiporters; Female; Formaldehyde; Ganglia, Spinal; Gene Expression Re | 2014 |
Altered formalin-induced pain and Fos induction in the periaqueductal grey of preadolescent rats following neonatal LPS exposure.
Topics: Analgesia; Animals; Animals, Newborn; Female; Formaldehyde; Hyperalgesia; Lipopolysaccharides; Pain; | 2014 |
Hemokinin-1 mediates pruriceptive processing in the rat spinal cord.
Topics: Animals; Disease Models, Animal; Formaldehyde; Histamine; Immunohistochemistry; Male; Nociception; P | 2014 |
Antinociceptive effect of some extracts from Ajuga chamaecistus Ging. ssp. tomentella (Boiss.) Rech. f. aerial parts.
Topics: Ajuga; Analgesics; Animals; Ether; Formaldehyde; Hexanes; Male; Methanol; Mice; Pain; Phytotherapy; | 2014 |
Intra-periaqueductal gray infusion of zeta inhibitory peptide attenuates pain-conditioned place avoidance in rats.
Topics: Analgesics; Animals; Avoidance Learning; Cell-Penetrating Peptides; Conditioning, Psychological; Dis | 2014 |
Role of the cerebrospinal fluid-contacting nucleus in the descending inhibition of spinal pain transmission.
Topics: Animals; Brain Stem; Cerebrospinal Fluid; Cholera Toxin; Disease Models, Animal; Formaldehyde; Heart | 2014 |
Increased sensitivity to inflammatory pain induced by subcutaneous formalin injection in serine racemase knock-out mice.
Topics: Animals; Blotting, Western; Formaldehyde; Immunohistochemistry; Inflammation; Injections, Subcutaneo | 2014 |
Isolation of a dihydrobenzofuran lignan, icariside E4, with an antinociceptive effect from Tabebuia roseo-alba (Ridley) Sandwith (Bignoniaceae) bark.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; | 2015 |
The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating β-endorphin release from spinal microglia.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; beta-Endorphin; Carrageenan; Cells, Cultured; Cyclobu | 2015 |
Effects of COX inhibition and LPS on formalin induced pain in the infant rat.
Topics: Animals; Animals, Newborn; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Formaldehyde; Lip | 2015 |
Sustained pain-related depression of behavior: effects of intraplantar formalin and complete freund's adjuvant on intracranial self-stimulation (ICSS) and endogenous kappa opioid biomarkers in rats.
Topics: Analgesics, Opioid; Animals; Body Weight; Conditioning, Operant; Disease Models, Animal; Formaldehyd | 2014 |
In vivo evaluation of analgesic, anti-inflammatory, and neuropharmacological activities of the chemical constituent from Nepeta clarkei.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Behavior, Animal | 2015 |
TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor.
Topics: Animals; Butadienes; Cells, Cultured; Disease Models, Animal; Enzyme Inhibitors; Extracellular Signa | 2014 |
Epidural dexamethasone decreased inflammatory hyperalgesia and spinal cPLA₂ expression in a rat formalin test.
Topics: Animals; Anti-Inflammatory Agents; Dexamethasone; Formaldehyde; Group IV Phospholipases A2; Hyperalg | 2014 |
Central nervous system activity of the ethanol leaf extract of Sida acuta in rats.
Topics: Acetic Acid; Analgesics; Animals; Antidepressive Agents; Apomorphine; Behavior, Animal; Ethanol; For | 2014 |
The activation of supraspinal GPR40/FFA1 receptor signalling regulates the descending pain control system.
Topics: Animals; Fenclonine; Formaldehyde; Male; Methylamines; Mice; Mice, Inbred Strains; Pain; Pain Measur | 2015 |
Intrathecal administration of clonidine or yohimbine decreases the nociceptive behavior caused by formalin injection in the marsh terrapin (Pelomedusa subrufa).
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; | 2014 |
Epidural administration of neostigmine-loaded nanofibers provides extended analgesia in rats.
Topics: Analgesics; Animals; Behavior, Animal; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Delayed | 2014 |
Synergistic effect of the interaction between curcumin and diclofenac on the formalin test in rats.
Topics: Analgesics; Animals; Curcumin; Diclofenac; Drug Synergism; Female; Formaldehyde; Pain; Pain Measurem | 2014 |
Central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test.
Topics: Adenosine; Animals; Formaldehyde; Male; Mice; Neuropeptides; Nociception; Pain; Pain Measurement; Re | 2015 |
Programming of formalin-induced nociception by neonatal LPS exposure: Maintenance by peripheral and central neuroimmune activity.
Topics: Animals; Animals, Newborn; Cell Count; Cell Degranulation; Encephalitis; Female; Formaldehyde; Hippo | 2015 |
Structure of an arabinogalactan from the edible tropical fruit tamarillo (Solanum betaceum) and its antinociceptive activity.
Topics: Acetic Acid; Analgesics; Animals; Female; Formaldehyde; Fruit; Galactans; Methylation; Mice; Molecul | 2015 |
Neurochemical properties of BDNF-containing neurons projecting to rostral ventromedial medulla in the ventrolateral periaqueductal gray.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related Peptide; Disease Mod | 2014 |
Physicochemical characterization and analgesic effect of inclusion complexes of essential oil from Hyptis pectinata L. Poit leaves with β-cyclodextrin.
Topics: Analgesics; Animals; beta-Cyclodextrins; Calorimetry, Differential Scanning; Female; Formaldehyde; G | 2015 |
Evaluation of antinociceptive effect of ethanol extract of Hedyotis corymbosa Linn. whole plant in mice.
Topics: Acetic Acid; Analgesics; Animals; Ethanol; Female; Formaldehyde; Glutamic Acid; Hedyotis; Hot Temper | 2015 |
Antinociceptive and anti-inflammatory activities of Geranium bellum and its isolated compounds.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Ellagic Acid; Female | 2014 |
Utilization of spray drying technique for improvement of dissolution and anti-inflammatory effect of Meloxicam.
Topics: Aerosols; Animals; Anti-Inflammatory Agents, Non-Steroidal; Buffers; Calorimetry, Differential Scann | 2015 |
Antinociceptive and anti-inflammatory activity of the siaresinolic acid, a triterpene isolated from the leaves of Sabicea grisea Cham. & Schltdl. var. grisea.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Disease Models, Animal; Formaldehyde; In | 2015 |
Analgesic principle from Curcuma amada.
Topics: Acetic Acid; Analgesics; Animals; Curcuma; Female; Formaldehyde; Male; Mice; Pain; Plant Extracts; R | 2015 |
Estrogen alters baseline and inflammatory-induced cytokine levels independent from hypothalamic-pituitary-adrenal axis activity.
Topics: Adrenalectomy; Animals; Cytokines; Estradiol; Estrogens; Formaldehyde; Ganglia, Spinal; Hypothalamo- | 2015 |
Anti-nociceptive, anti-inflammatory and toxicological evaluation of Fang-Ji-Huang-Qi-Tang in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aristolochia; Aristolochic Acids; Astrag | 2015 |
Activities of 2-phthalimidethyl nitrate and 2-phthalimidethanol in the models of nociceptive response and edema induced by formaldehyde in mice and preliminary investigation of the underlying mechanisms.
Topics: Analgesics; Animals; Edema; Formaldehyde; Male; Mice; Mice, Inbred C57BL; Narcotic Antagonists; Noci | 2015 |
The major histocompatibility complex genes impact pain response in DA and DA.1U rats.
Topics: Animals; Animals, Congenic; Disease Models, Animal; Disinfectants; Female; Formaldehyde; Gene Expres | 2015 |
Formalin evokes calcium transients from the endoplasmatic reticulum.
Topics: Animals; Calcium; Calcium Signaling; Endoplasmic Reticulum; Formaldehyde; Ganglia, Spinal; Gene Expr | 2015 |
Exploring new pharmacology and toxicological screening and safety evaluation of one widely used formulation of Nidrakar Bati from South Asia region.
Topics: Acetic Acid; Analgesics; Animals; Anti-Anxiety Agents; Anti-Inflammatory Agents; Asia; Behavior, Ani | 2015 |
Antinociceptive effect of methanol extract of leaves of Persicaria hydropiper in mice.
Topics: Acetic Acid; Acrolein; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Bangladesh | 2015 |
The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Formaldehyde; Inflammation; Mice; Mice, Knocko | 2015 |
GABAA-benzodiazepine receptors in the dorsomedial (Dm) telencephalon modulate restraint-induced antinociception in the fish Leporinus macrocephalus.
Topics: Analysis of Variance; Animals; Fishes; Flumazenil; Formaldehyde; GABA Modulators; Locomotion; Microi | 2015 |
[Effects of intra-periaqueductal gray injection of zeta pseudosubstrate inhibitory peptide on sensory and affective components of pain].
Topics: Animals; Formaldehyde; Pain; Pain Measurement; Peptides; Periaqueductal Gray; Rats | 2015 |
GABA acting on GABAB receptors located in a medullary pain facilitatory area enhances nociceptive behaviors evoked by intraplantar formalin injection.
Topics: Animals; Baclofen; Disease Models, Animal; Formaldehyde; GABA-B Receptor Agonists; GABA-B Receptor A | 2015 |
Effects of microinjection of histamine into the anterior cingulate cortex on pain-related behaviors induced by formalin in rats.
Topics: Animals; Formaldehyde; Gyrus Cinguli; Histamine; Male; Microinjections; Pain; Pain Measurement; Rats | 2015 |
Antinociceptive and anti-inflammatory activities of Schefflera octophylla extracts.
Topics: Acetic Acid; Analgesics; Animals; Ankle Joint; Anti-Inflammatory Agents; Araliaceae; Arthritis, Expe | 2015 |
Antinociceptive and Anti-Inflammatory Activities of Telfairia occidentalis Hydroethanolic Leaf Extract (Cucurbitaceae).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cucurbitaceae; Edema; Femal | 2015 |
Targeting cells of the myeloid lineage attenuates pain and disease progression in a prostate model of bone cancer.
Topics: Aminopyridines; Analgesics; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Bone a | 2015 |
Anti-nociceptive activity of the crude extract of Myrianthus arboreus P. Beauv (Cecropiaceae) in mice.
Topics: Acetic Acid; Analgesics; Animals; Complex Mixtures; Formaldehyde; Hot Temperature; Lethal Dose 50; M | 2015 |
Changes in Activity of the Same Thalamic Neurons to Repeated Nociception in Behaving Mice.
Topics: Animals; Behavior, Animal; Formaldehyde; Male; Mice; Neurons; Nociception; Pain; Synaptic Transmissi | 2015 |
Analgesic and anti-inflammatory activities of the ethanol extract of Taxillus tsaii Chiu in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cytokines; Edema; Ethanol; | 2015 |
Effects of acute and sustained pain manipulations on performance in a visual-signal detection task of attention in rats.
Topics: Animals; Attention; Behavior, Animal; Edema; Formaldehyde; Freund's Adjuvant; Hyperalgesia; Lactic A | 2015 |
Antiedematogenic Evaluation of Copaifera langsdorffii Leaves Hydroethanolic Extract and Its Major Compounds.
Topics: Animals; Carrageenan; Cell Movement; Dextrans; Edema; Fabaceae; Formaldehyde; Humans; Interleukin-6; | 2015 |
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Carrageenan; Cycloox | 2015 |
Perinatal 17α-ethinylestradiol exposure affects formalin-induced responses in middle-aged male (but not female) rats.
Topics: Animals; Animals, Suckling; Behavior, Animal; Brain; Ethinyl Estradiol; Female; Formaldehyde; Groomi | 2015 |
Antinociceptive and anti-inflammatory effects of Brazilian red propolis extract and formononetin in rodents.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Brazil; Carrageenan; Cell Movement; Edem | 2015 |
Microinjection of orexin-A into the rat locus coeruleus nucleus induces analgesia via cannabinoid type-1 receptors.
Topics: Analgesics; Analysis of Variance; Animals; Benzoxazoles; Carrier Proteins; Dose-Response Relationshi | 2015 |
Acidosis and Formaldehyde Secretion as a Possible Pathway of Cancer Pain and Options for Improved Cancer Pain Control.
Topics: Acidosis; Aldehyde Dehydrogenase; Dichloroacetic Acid; Formaldehyde; Glutathione; Humans; Hydrogen-I | 2015 |
Inhibition of Inactive States of Tetrodotoxin-Sensitive Sodium Channels Reduces Spontaneous Firing of C-Fiber Nociceptors and Produces Analgesia in Formalin and Complete Freund's Adjuvant Models of Pain.
Topics: Action Potentials; Analgesia; Analgesics; Animals; Formaldehyde; Freund's Adjuvant; Male; NAV1.7 Vol | 2015 |
Differential effects of general anesthetics on anxiety-like behavior in formalin-induced pain: involvement of ERK activation in the anterior cingulate cortex.
Topics: Anesthetics, Inhalation; Animals; Anxiety; Behavior, Animal; Extracellular Signal-Regulated MAP Kina | 2015 |
Pharmacological evidence favouring the traditional use of the root bark of Condalia buxifolia Reissek in the relief of pain and inflammation in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Edema; Female; Formald | 2015 |
GABAergic neurons of the medial septum play a nodal role in facilitation of nociception-induced affect.
Topics: Animals; Behavior, Animal; Bicuculline; Formaldehyde; GABAergic Neurons; Gyrus Cinguli; Hippocampus; | 2015 |
Honokiol for the Treatment of Neonatal Pain and Prevention of Consequent Neurobehavioral Disorders.
Topics: Analgesics; Animals; Biphenyl Compounds; Formaldehyde; Lignans; Magnolia; Male; Molecular Structure; | 2015 |
Evaluation of anticonvulsant and antinociceptive properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and 3-methylpyrrolidine-2,5-dione.
Topics: Analgesics; Animals; Anticonvulsants; Calcium Channels, L-Type; Formaldehyde; Hot Temperature; Male; | 2016 |
Anti-nociceptive activity of a few structurally related trimethoxy flavones and possible mechanisms involved.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Flavones; Formaldehyde; Male | 2016 |
Analgesic Effects of Danggui-Shaoyao-San on Various "Phenotypes" of Nociception and Inflammation in a Formalin Pain Model.
Topics: Analgesics; Animals; Behavior, Animal; Cyclooxygenase 2; Dextran Sulfate; Disease Models, Animal; Dr | 2016 |
Sodium butyrate and its synthetic amide derivative modulate nociceptive behaviors in mice.
Topics: Acetic Acid; Amides; Analgesics; Anilides; Animals; Butyric Acid; Formaldehyde; Hot Temperature; Hyp | 2016 |
Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae).
Topics: Acetic Acid; Analgesics; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents; Cell Line, Tu | 2016 |
Effects of intrathecal amylin on formalin-induced nociception and on cAMP accumulation in the rat embryonic spinal cells.
Topics: Amylin Receptor Agonists; Analgesics; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; | 2016 |
The antinociceptive effect and mechanism of action of SY0916.
Topics: Analgesics; Animals; Brain Stem; Cell Line; Dinoprostone; Female; Formaldehyde; Hot Temperature; Ket | 2016 |
Antinociceptive and anti-inflammatory effects of a Geissospermum vellosii stem bark fraction.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Apocynaceae; Carrageenan; Disease Models, Animal; Ede | 2016 |
Liver X Receptor β Is Involved in Formalin-Induced Spontaneous Pain.
Topics: Animals; Formaldehyde; Liver X Receptors; Male; Mice; Mice, Knockout; Pain; Pain Measurement | 2017 |
Analgesic, anti-inflammatory and anti-platelet activities of Buddleja crispa.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Blood Platelets; Carra | 2016 |
Hydroxymethylation of microRNA-365-3p Regulates Nociceptive Behaviors via Kcnh2.
Topics: 5-Methylcytosine; Animals; Cytosine; Dioxygenases; Disease Models, Animal; DNA Methylation; DNA-Bind | 2016 |
Involvement of opioid receptors in the systemic and peripheral antinociceptive actions of montelukast in the animal models of pain.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Behavior, Animal; Cyclopropanes; Disease Models, Animal; | 2016 |
Cycloartanes from Oxyanthus pallidus and derivatives with analgesic activities.
Topics: Analgesics; Animals; Antioxidants; Female; Formaldehyde; Hyperalgesia; Inflammation; Liver; Male; Ma | 2016 |
Involvement of NIPSNAP1, a neuropeptide nocistatin-interacting protein, in inflammatory pain.
Topics: Animals; Cyclooxygenase Inhibitors; Dinoprostone; Formaldehyde; Ganglia, Spinal; Inflammation; Inter | 2016 |
Evaluation of antinociceptive activity of methanolic extract of leaves of Stephania japonica Linn.
Topics: Acetic Acid; Analgesics; Animals; Formaldehyde; Glutamic Acid; Hot Temperature; Male; Mice; Naloxone | 2016 |
Chalcone Derivatives Activate and Desensitize the Transient Receptor Potential Ankyrin 1 Cation Channel, Subfamily A, Member 1 TRPA1 Ion Channel: Structure-Activity Relationships in vitro and Anti-Nociceptive and Anti-inflammatory Activity in vivo.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Calcium; Chalcones; Disease Models, Animal; Dose-Resp | 2016 |
Antinociceptive and anti-inflammatory effects of Memora nodosa and allantoin in mice.
Topics: Acetic Acid; Allantoin; Analgesics; Animals; Anti-Inflammatory Agents; Bignoniaceae; Carrageenan; Ed | 2016 |
Antinociceptive effects of the aqueous and methanol extracts of the leaves of Pittosporum mannii Hook. F. (Pittosporaceae) in mice.
Topics: Acetic Acid; Analgesics; Animals; Artemia; Capsaicin; Female; Formaldehyde; Glutamic Acid; Hot Tempe | 2016 |
A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase.
Topics: Acrylamides; Amidohydrolases; Analgesia; Animals; Arachidonic Acid; Bridged Bicyclo Compounds, Heter | 2016 |
The leguminous lectin of Lonchocarpus araripensis promotes antinociception via mechanisms that include neuronal inhibition of Na(+) currents.
Topics: Analgesics; Animals; Capsaicin; Fabaceae; Formaldehyde; Ganglia, Spinal; Hot Temperature; Lectins; M | 2016 |
Amylin modulates the formalin-induced tonic pain behaviours in rats.
Topics: Amylin Receptor Agonists; Animals; Brain; Disease Models, Animal; Formaldehyde; Injections, Spinal; | 2016 |
D1- and D2-like dopamine receptors within the nucleus accumbens contribute to stress-induced analgesia in formalin-related pain behaviours in rats.
Topics: Analgesia; Animals; Benzazepines; Dopamine; Dopamine Antagonists; Formaldehyde; Male; Nucleus Accumb | 2016 |
Antinociceptive effects of dehydrocorydaline in mouse models of inflammatory pain involve the opioid receptor and inflammatory cytokines.
Topics: Acetates; Alkaloids; Analgesics; Animals; Anti-Inflammatory Agents; Cytokines; Disease Models, Anima | 2016 |
Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.
Topics: Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Injecti | 2016 |
Effects of neonatal pain, stress and their interrelation on pain sensitivity in later life in male rats.
Topics: Age Factors; Animals; Animals, Newborn; Female; Formaldehyde; Male; Maternal Behavior; Maternal Depr | 2016 |
The potential role of serotonergic mechanisms in the spinal oxytocin-induced antinociception.
Topics: Animals; Electric Stimulation; Formaldehyde; Hyperalgesia; Male; Methiothepin; Nociception; Oxytocin | 2016 |
Activational action of testosterone on androgen receptors protects males preventing temporomandibular joint pain.
Topics: 5-alpha Reductase Inhibitors; Androgen Antagonists; Animals; Dutasteride; Estradiol; Estrogen Recept | 2017 |
Analgesic and anti-inflammatory actions on bradykinin route of a polysulfated fraction from alga Ulva lactuca.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Bradykinin; Carrageenan; Chemical Fracti | 2016 |
Hormonal and molecular effects of restraint stress on formalin-induced pain-like behavior in male and female mice.
Topics: Analysis of Variance; Animals; Corticosterone; Disease Models, Animal; Female; Fixatives; Formaldehy | 2016 |
Inoculation of Lewis lung carcinoma cells enhances formalin-induced pain behavior and spinal Fos expression in mice.
Topics: Analgesics, Non-Narcotic; Animals; Cancer Pain; Carcinoma, Lewis Lung; Formaldehyde; Ibuprofen; Male | 2017 |
N-palmitoylethanolamide in the anterior cingulate cortex attenuates inflammatory pain behaviour indirectly via a CB1 receptor-mediated mechanism.
Topics: Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cannabinoid Receptor Antagonists; Cohort S | 2016 |
Anti-oxidant, anti-inflammatory, analgesic and antipyretic activities of grapevine leaf extract (Vitis vinifera) in mice and identification of its active constituents by LC-MS/MS analyses.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Antipyretics; Behavior, An | 2016 |
Long-Term Effects of Neonatal Pain and Stress on Reactivity of the Nociceptive System.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Female; Formaldehyde; Inflammation; Male; | 2016 |
CaMKIIα underlies spontaneous and evoked pain behaviors in Berkeley sickle cell transgenic mice.
Topics: Anemia, Sickle Cell; Anesthetics, Local; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein | 2016 |
Modulation of formalin-induced pain-related behaviour by clonidine and yohimbine in the Speke's hinged tortoise (Kiniskys spekii).
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Formaldehyde; Pain; Turtles; Yohimbine | 2017 |
Concurrent bullatine A enhances morphine antinociception and inhibits morphine antinociceptive tolerance by indirect activation of spinal κ-opioid receptors.
Topics: Alkaloids; Analgesics; Animals; Behavior, Animal; Diterpenes; Dose-Response Relationship, Drug; Drug | 2017 |
Dissociation of morphine analgesic effects in the sensory and affective components of formalin-induced spontaneous pain in male and female rats.
Topics: Affect; Analgesics, Opioid; Animals; Avoidance Learning; Conditioning, Psychological; Dose-Response | 2017 |
Antinociceptive effect of methanol extract of Dalbergia sissoo leaves in mice.
Topics: Acetic Acid; Analgesics; Animals; Cyclic GMP; Dalbergia; Disease Models, Animal; Drug Evaluation, Pr | 2017 |
Lentiviral vector-encoded microRNA-based shRNA-mediated gene knockdown of
Topics: Animals; Formaldehyde; Freund's Adjuvant; Gene Knockdown Techniques; Genetic Vectors; Lentivirus; Ma | 2017 |
Evaluation of acute toxicity, sedative and analgesic effects of Taverniera glabra methanolic extract on mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Central Nervous System; Disease Models, Animal; | 2016 |
Mild Social Stress in Mice Produces Opioid-Mediated Analgesia in Visceral but Not Somatic Pain States.
Topics: Acetic Acid; Animals; Capsaicin; Corticosterone; Cues; Disease Models, Animal; Formaldehyde; Male; M | 2017 |
Seed and peel essential oils obtained from Campomanesia adamantium fruit inhibit inflammatory and pain parameters in rodents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Chemotaxis, Leukocyte; Cold Temperature; | 2017 |
Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain.
Topics: Animals; Biomarkers; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Gene Expression; Gene Kn | 2017 |
Analgesic Effect of Xenon in Rat Model of Inflammatory Pain.
Topics: Administration, Inhalation; Analgesics; Animals; Behavior, Animal; Formaldehyde; Hot Temperature; In | 2017 |
Effect of Low Dose Lead (Pb) Administration on Tail Immersion Test and Formalin-induced Pain in Wistar Rats: Possible Modulatory Role of Cobalt (II) Chloride.
Topics: Animals; Behavior, Animal; Cobalt; Disease Models, Animal; Female; Formaldehyde; Male; Organometalli | 2017 |
Effects of luteolin and luteolin-morphine co-administration on acute and chronic pain and sciatic nerve ligated-induced neuropathy in mice.
Topics: Acute Disease; Analgesics; Animals; Chronic Pain; Disease Models, Animal; Drug Therapy, Combination; | 2017 |
Activation of the NMDA receptor-neuronal nitric oxide synthase pathway within the ventral bed nucleus of the stria terminalis mediates the negative affective component of pain.
Topics: Animals; Conditioning, Operant; Cyclic N-Oxides; Disease Models, Animal; Excitatory Postsynaptic Pot | 2017 |
New insights of dimethyl sulphoxide effects (DMSO) on experimental in vivo models of nociception and inflammation.
Topics: Administration, Oral; Animals; Anti-Infective Agents, Local; Dimethyl Sulfoxide; Edema; Formaldehyde | 2008 |
[Effect of intrathecal pumping tramadol on the immune function in rats with formalin pain].
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Injections, Spinal; Kil | 2008 |
Zonisamide suppresses pain symptoms of formalin-induced inflammatory and streptozotocin-induced diabetic neuropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Formaldehyde; Inflammation; Isoxazo | 2008 |
Quercetin: further investigation of its antinociceptive properties and mechanisms of action.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cholinergic Agents; Disease Models, | 2008 |
Minodronic acid, a third-generation bisphosphonate, antagonizes purinergic P2X(2/3) receptor function and exerts an analgesic effect in pain models.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics, Non-Narcotic; Animals; Bone Density Conservation Ag | 2008 |
Antinociceptive action of GLYX-13: an N-methyl-D-aspartate receptor glycine site partial agonist.
Topics: Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Disease Models, Animal; | 2008 |
Interaction between morphine and norketamine enantiomers in rodent models of nociception.
Topics: Analgesics, Opioid; Animals; Constriction, Pathologic; Dose-Response Relationship, Drug; Drug Combin | 2008 |
Effects of norketamine enantiomers in rodent models of persistent pain.
Topics: Animals; Behavior, Animal; Chronic Disease; Constriction, Pathologic; Dose-Response Relationship, Dr | 2008 |
[Periaqueductal gray administration of HSV-I amplicon vector-mediated HPPE gene therapy of nocicepion in rats with formalin-induced pain].
Topics: Animals; Enkephalins; Formaldehyde; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Herp | 2008 |
Differential modulation of inflammatory pain by a selective estrogen receptor beta agonist.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chronic Disease; Estro | 2008 |
Antinociceptive effect of amygdalin isolated from Prunus armeniaca on formalin-induced pain in rats.
Topics: Amygdalin; Analgesics; Animals; Behavior, Animal; Formaldehyde; Gene Expression; Genes, fos; Immunoh | 2008 |
Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Ficus; For | 2008 |
Brain nociceptive imaging in rats using (18)f-fluorodeoxyglucose small-animal positron emission tomography.
Topics: Analgesics; Analysis of Variance; Animals; Brain; Fluorodeoxyglucose F18; Formaldehyde; Functional L | 2008 |
Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Blood-Brain Barrier; Carrageenan; Drug Evaluation, P | 2008 |
Role of central dopaminergic circuitry in pain processing and nitroglycerin-induced hyperalgesia.
Topics: Adrenergic Agents; Animals; Basal Ganglia; Denervation; Dopamine; Formaldehyde; Hyperalgesia; Image | 2008 |
Differential expression of phosphorylated Ca2+/calmodulin-dependent protein kinase II and phosphorylated extracellular signal-regulated protein in the mouse hippocampus induced by various nociceptive stimuli.
Topics: Acetic Acid; Analysis of Variance; Animals; Behavior, Animal; Benzylamines; Calcium-Calmodulin-Depen | 2008 |
Anti-inflammatory and analgesic properties in a rodent model of a (1-->3),(1-->6)-linked beta-glucan isolated from Pleurotus pulmonarius.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillary Permeability | 2008 |
Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test.
Topics: Acid Sensing Ion Channels; Animals; Behavior, Animal; Formaldehyde; Freund's Adjuvant; Hot Temperatu | 2009 |
TRPA1-mediated nociception.
Topics: Animals; Formaldehyde; Histamine; Mice; Nociceptors; Pain; Transient Receptor Potential Channels; TR | 2008 |
TRPA1-mediated nociception: response to letter by Fischer et al.
Topics: Animals; Formaldehyde; Mice; Nociceptors; Pain; Transient Receptor Potential Channels; TRPA1 Cation | 2008 |
Intracerebroventricular fluvoxamine administration inhibited pain behavior but increased Fos expression in affective pain pathways.
Topics: Affect; Animals; Antidepressive Agents, Second-Generation; Behavior, Animal; Fluvoxamine; Formaldehy | 2009 |
Stress- and non-stress-mediated mechanisms are involved in pain-induced apoptosis in hippocampus and dorsal lumbar spinal cord in rats.
Topics: Adrenalectomy; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Corticosterone; Formaldehy | 2008 |
A BOLD-fMRI study of cerebral activation induced by injection of algesic chemical substances into the anesthetized rat forepaw.
Topics: Animals; Capsaicin; Dose-Response Relationship, Drug; Forelimb; Formaldehyde; Isoflurane; Magnetic R | 2008 |
Dexmedetomidine and ST-91 analgesia in the formalin model is mediated by alpha2A-adrenoceptors: a mechanism of action distinct from morphine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Analgesics; Animals; Clonidine; Dex | 2008 |
Intra-hippocampal tonic inhibition influences formalin pain-induced pyramidal cell suppression, but not excitation in dorsal field CA1 of rat.
Topics: Analysis of Variance; Animals; Bicuculline; Dendrites; Electric Stimulation; Electroencephalography; | 2008 |
Activation of micro, delta or kappa opioid receptors by DAMGO, DPDPE, U-50488 or U-69593 respectively causes antinociception in the formalin test in the naked mole-rat (Heterocephalus glaber).
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2009 |
Comparison of nociceptive behavior in prostaglandin E, F, D, prostacyclin and thromboxane receptor knockout mice.
Topics: Animals; Cyclooxygenase 1; Cyclooxygenase 2; Female; Fluorescent Antibody Technique; Formaldehyde; H | 2009 |
Effects of maternal corticosterone and stress on behavioral and hormonal indices of formalin pain in male and female offspring of different ages.
Topics: Adrenalectomy; Aging; Animals; Behavior, Animal; Corticosterone; Female; Formaldehyde; Male; Multiva | 2009 |
Mechanisms involved in the antinociceptive effect caused by diphenyl diselenide in the formalin test.
Topics: Administration, Oral; Analgesics; Animals; Benzene Derivatives; Calcium; Cyclic GMP; Disease Models, | 2008 |
Evaluation for the interaction between intrathecal melatonin and clonidine or neostigmine on formalin-induced nociception.
Topics: Analgesics, Non-Narcotic; Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Drug | 2008 |
Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex.
Topics: Animals; Behavior, Animal; Formaldehyde; Gene Products, tat; Inflammation; Learning; Mice; Nervous S | 2008 |
Warm needle acupuncture at Pungsi (GB31) has an enhanced analgesic effect on formalin-induced pain in rats.
Topics: Acupuncture Analgesia; Acupuncture Points; Analysis of Variance; Animals; Behavior, Animal; Formalde | 2009 |
Acid increases inflammatory pain in rats: effect of local peripheral ASICs inhibitors.
Topics: Acid Sensing Ion Channels; Amiloride; Analgesics; Animals; Capsaicin; Female; Formaldehyde; Hydrogen | 2009 |
Studies on the analgesic, anti-inflammatory and antipyretic effects of Parquetina nigrescens leaf extract.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Apocynaceae; Carrageenan; E | 2009 |
Additive antinociception between intrathecal sildenafil and morphine in the rat formalin test.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Sy | 2008 |
Effects of NO-modulating agents on the development of acute painful reaction in rats.
Topics: Agmatine; Animals; Arginine; Behavior, Animal; Formaldehyde; Inflammation; Injections, Intraperitone | 2008 |
Synergism between NSAIDs in the orofacial formalin test in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Drug Synergism; Face; Female; Formaldehyde; Male; | 2009 |
Pharmacological assessment of the rat formalin test utilizing the clinically used analgesic drugs gabapentin, lamotrigine, morphine, duloxetine, tramadol and ibuprofen: influence of low and high formalin concentrations.
Topics: Analgesics; Animals; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Form | 2009 |
Antinociceptive effects of hydroalcoholic extract of Thymus vulgaris.
Topics: Analgesics; Animals; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Formal | 2009 |
siRNA-mediated knockdown of the NR1 subunit gene of the NMDA receptor attenuates formalin-induced pain behaviors in adult rats.
Topics: Animals; Blotting, Western; Formaldehyde; Gene Knockdown Techniques; Genetic Vectors; Immunohistoche | 2009 |
Involvement of activated astrocyte and microglia of locus coeruleus in cardiac pain processing after acute cardiac injury.
Topics: Acute Disease; Animals; Astrocytes; CD11b Antigen; Disease Models, Animal; Formaldehyde; Glial Fibri | 2009 |
[Effect of a simple morphine system injection in some aminoacids in the anterior cingulate cortex during acute pain].
Topics: Acute Disease; Amino Acids; Analgesics, Opioid; Animals; Arginine; Aspartic Acid; Cerebral Cortex; D | 2008 |
Effects of mepyramine and famotidine on the physostigmine-induced antinociception in the formalin test in rats.
Topics: Analgesics; Animals; Atropine; Drug Interactions; Famotidine; Formaldehyde; Histamine H1 Antagonists | 2008 |
Acute inflammation induces segmental, bilateral, supraspinally mediated opioid release in the rat spinal cord, as measured by mu-opioid receptor internalization.
Topics: Acute Disease; Anesthesia; Animals; Formaldehyde; Freund's Adjuvant; Inflammation; Injections, Spina | 2009 |
Antinociceptive effect of the cannabinoid agonist, WIN 55,212-2, in the orofacial and temporomandibular formalin tests.
Topics: Analgesics; Analgesics, Opioid; Anesthetics, Dissociative; Animals; Anti-Inflammatory Agents, Non-St | 2010 |
Intrathecal gabapentin does not act as a hyperpolarization-activated cyclic nucleotide-gated channel activator in the rat formalin test.
Topics: Amines; Analgesics; Animals; Cardiotonic Agents; Cyclic Nucleotide-Gated Cation Channels; Cyclohexan | 2009 |
Activation of NMDA receptor is associated with up-regulation of COX-2 expression in the spinal dorsal horn during nociceptive inputs in rats.
Topics: Animals; Blotting, Western; Cyclooxygenase 2; Dizocilpine Maleate; Dose-Response Relationship, Drug; | 2009 |
Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Cinnamates; Depsides; Dose-Response Relationsh | 2009 |
Activation of ERK in the locus coeruleus following acute noxious stimulation.
Topics: Analysis of Variance; Animals; Cell Count; Extracellular Signal-Regulated MAP Kinases; Formaldehyde; | 2009 |
Discovery of inducible nitric oxide synthase (iNOS) inhibitor development candidate KD7332, part 1: Identification of a novel, potent, and selective series of quinolinone iNOS dimerization inhibitors that are orally active in rodent pain models.
Topics: Administration, Oral; Animals; Cell Line; Constriction, Pathologic; Disease Models, Animal; Drug Dis | 2009 |
Gamma-aminobutyric acid amides of nortriptyline and fluoxetine display improved pain suppressing activity.
Topics: Analgesics; Animals; Antidepressive Agents; Anxiety; Behavior, Animal; Fluoxetine; Formaldehyde; gam | 2009 |
Effects of intrathecal injection of nicotine on the analgesic effects of isoflurane in a model of inflammatory pain.
Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Isoflurane; Mice; Nicotine; Pain; Pain Thresh | 2009 |
Analgesic activity of myricetin isolated from Myrica rubra Sieb. et Zucc. leaves.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase Inhibitors; Din | 2009 |
Role of peripheral and spinal 5-HT6 receptors according to the rat formalin test.
Topics: Animals; Female; Formaldehyde; Hindlimb; Inflammation; Injections; Nerve Endings; Pain; Pain Measure | 2009 |
MKK3, an upstream activator of p38, contributes to formalin phase 2 and late allodynia in mice.
Topics: Acute Disease; Animals; Astrocytes; Chronic Disease; Enzyme Activation; Formaldehyde; MAP Kinase Kin | 2009 |
Roles of endothelin ETA and ETB receptors in nociception and chemical, thermal and mechanical hyperalgesia induced by endothelin-1 in the rat hindpaw.
Topics: Animals; Dose-Response Relationship, Drug; Endothelin-1; Formaldehyde; Hindlimb; Hyperalgesia; Male; | 2009 |
Antinociceptive activity of Amaranthus spinosus in experimental animals.
Topics: Acetic Acid; Amaranthus; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carr | 2009 |
Effects of systemic bicuculline or morphine on formalin-evoked pain-related behaviour and c-Fos expression in trigeminal nuclei after formalin injection into the lip or tongue in rats.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Bicuculline; Formaldehyde; GABA Antagonis | 2009 |
Formalin-induced increase in P2X(3) receptor expression in dorsal root ganglia: implications for nociception.
Topics: Action Potentials; Animals; Blotting, Western; Female; Formaldehyde; Ganglia, Spinal; Immunohistoche | 2009 |
Formalin-induced behavioural hypersensitivity and neuronal hyperexcitability are mediated by rapid protein synthesis at the spinal level.
Topics: Animals; Behavior, Animal; Electrophysiology; Formaldehyde; Male; Neuronal Plasticity; Pain; Protein | 2009 |
The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Brain; Calibration; Chromatography, High Pressu | 2009 |
Intracerebroventricular administration of 26RFa produces an analgesic effect in the rat formalin test.
Topics: Analgesics, Non-Narcotic; Animals; Anti-Anxiety Agents; Arginine; Formaldehyde; Hot Temperature; Inj | 2009 |
Opposing actions of neuronal nitric oxide synthase isoforms in formalin-induced pain in mice.
Topics: Analysis of Variance; Animals; Arginine; Drug Tolerance; Formaldehyde; Hyperalgesia; Injections, Spi | 2009 |
Inhibitory effect of lidocaine on pain and itch using formalin-induced nociception and 5'-guanidinonaltrindole-induced scratching models in mice: behavioral and neuroanatomical evidence.
Topics: Animals; Behavior, Animal; Formaldehyde; Gene Expression Regulation; Guanidines; Lidocaine; Male; Mi | 2009 |
Antinociceptive effects of (O-methyl)-N-benzoyl tyramine (riparin I) from Aniba riparia (Nees) Mez (Lauraceae) in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Arginine; Behavior, Anim | 2009 |
Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum.
Topics: Acetic Acid; Analgesics; Anaphylaxis; Animals; Behavior, Animal; Chromobacterium; Dose-Response Rela | 2010 |
Evidence for a role of NTS2 receptors in the modulation of tonic pain sensitivity.
Topics: Animals; Formaldehyde; Histamine H1 Antagonists, Non-Sedating; Inflammation; Male; Neurotensin; Pain | 2009 |
Antinociceptive activity of a new benzofuranone derived from a chalcone.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Benzofurans; Capsaicin; Chalc | 2009 |
The Rac GTPase-activating bacterial protein toxin CNF1 induces analgesia up-regulating mu-opioid receptors.
Topics: Analgesics; Animals; Bacterial Toxins; Cell Line, Tumor; Cerebellum; Disease Models, Animal; Dose-Re | 2009 |
Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies.
Topics: Animals; Body Weight; Chronic Disease; Cold Temperature; Disease Models, Animal; Formaldehyde; Hot T | 2009 |
[Effect of preemptive intrathecal lornoxicam on foot swelling of formalin test in rats].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Edema; Foot Diseases; Formaldehyde; Injections, Sp | 2009 |
Formalin-induced differential activation of nucleus cuneiformis neurons in the rat: an electrophysiological study.
Topics: Action Potentials; Analgesics, Opioid; Animals; Behavior, Animal; Central Nervous System Agents; For | 2010 |
Antinociceptive activity of the essential oil of Zingiber zerumbet.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; | 2010 |
Activation of peripheral kappa/delta opioid receptors mediates 15-deoxy-(Delta12,14)-prostaglandin J2 induced-antinociception in rat temporomandibular joint.
Topics: Analgesics; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Formaldehyde; Inflammation; KATP | 2009 |
Peripheral estradiol induces temporomandibular joint antinociception in rats by activating the nitric oxide/cyclic guanosine monophosphate signaling pathway.
Topics: Analgesics; Animals; Cyclic GMP; Diestrus; Estradiol; Female; Formaldehyde; Guanylate Cyclase; Male; | 2009 |
Role of opioid receptors in the reduction of formalin-induced secondary allodynia and hyperalgesia in rats.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2009 |
NMDA NR2A and NR2B receptors in the rostral anterior cingulate cortex contribute to pain-related aversion in male rats.
Topics: Animals; Avoidance Learning; Blotting, Western; Cerebral Cortex; Electrophysiology; Fear; Formaldehy | 2009 |
Antinociceptive and anti-inflammatory activities of iridoid glycosides extract of Lamiophlomis rotata (Benth.) Kudo.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillary Permeability | 2010 |
Roles of corticosterone in formalin-induced conditioned place aversion in rats.
Topics: Adrenal Cortex; Animals; Avoidance Learning; Conditioning, Psychological; Corticosterone; Formaldehy | 2009 |
Analgesic and anti-inflammatory activities of a water extract of Trachelospermum jasminoides (Apocynaceae).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Apocynaceae; Behavior, Ani | 2009 |
NADPH-d/NOS reactivity in the lumbar dorsal horn of congenitally hypothyroid pups before and after formalin pain induction.
Topics: Animals; Animals, Newborn; Formaldehyde; Hypothyroidism; Lumbosacral Region; NADPH Dehydrogenase; Ni | 2009 |
Evaluation of anti-inflammatory and analgesic activity of a novel rigid 3, 4-dihydroxy chalcone in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Aspirin; Chalcone; Dose-Response | 2009 |
Anti-inflammatory and analgesic properties of cis-mulberroside A from Ramulus mori.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Disaccharides; D | 2010 |
Licking decreases phosphorylation of extracellular signal-regulated kinase in the dorsal horn of the spinal cord after a formalin test.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Down-Regulation; Extracellular Signal-Regulated M | 2009 |
Iron-deficiency sensitizes mice to acute pain stimuli and formalin-induced nociception.
Topics: Aging; Animals; Animals, Newborn; Biotinylation; Diet; Formaldehyde; Genes, fos; Hot Temperature; Im | 2009 |
Intrathecal injection of GluR6 antisense oligodeoxynucleotides alleviates acute inflammatory pain of rectum in rats.
Topics: Analgesics; Animals; Formaldehyde; GluK2 Kainate Receptor; Immunoblotting; Injections, Spinal; Male; | 2009 |
Effects of intra-basolateral amygdala administration of rimonabant on nociceptive behaviour and neuronal activity in the presence or absence of contextual fear.
Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Cathete | 2010 |
Suppression of formalin-induced nociception by cilnidipine, a voltage-dependent calcium channel blocker.
Topics: Administration, Oral; Amines; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, N-Typ | 2009 |
Contribution of endogenous opioids to gonadal hormones-induced temporomandibular joint antinociception.
Topics: Analgesia; Analysis of Variance; Androgens; Animals; Dose-Response Relationship, Drug; Estradiol; Es | 2009 |
Visualizing acute pain-morphine interaction in descending monoamine nuclei with Fos.
Topics: Analgesics, Opioid; Animals; Brain Stem; Cell Count; Formaldehyde; Immunohistochemistry; Male; Micro | 2010 |
The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats.
Topics: Animals; Dose-Response Relationship, Drug; Female; Formaldehyde; Functional Laterality; Hindlimb; Pa | 2010 |
Exaggerated response of a vasopressin-enhanced green fluorescent protein transgene to nociceptive stimulation in the rat.
Topics: Afferent Pathways; Animals; Corticotropin-Releasing Hormone; Formaldehyde; Gene Expression Regulatio | 2009 |
Mediating roles of the vanilloid receptor TRPV1 in activation of rat primary afferent nociceptive neurons by formaldehyde.
Topics: Acetanilides; Action Potentials; Animals; Capsaicin; Formaldehyde; Ganglia, Spinal; Nociceptors; Pai | 2009 |
Contralateral paw sensitization following injection of endothelin-1: effects of local anesthetics differentiate peripheral and central processes.
Topics: Anesthetics, Local; Animals; Brain; Endothelin-1; Foot; Formaldehyde; Functional Laterality; Hindlim | 2010 |
Comparison of milnacipran, duloxetine and pregabalin in the formalin pain test and in a model of stress-induced ultrasonic vocalizations in rats.
Topics: Adrenergic Uptake Inhibitors; Analgesics; Analysis of Variance; Animals; Cyclopropanes; Dose-Respons | 2010 |
Role of nitric oxide in the rat hippocampal CA1 in morphine antinociception.
Topics: Analgesics, Opioid; Animals; Arginine; CA1 Region, Hippocampal; Central Nervous System Agents; Dose- | 2010 |
Intra-periaqueductal grey microinjections of an imidazo[1,2-b]pyridazine derivative, DM2, affects rostral ventromedial medulla cell activity and shows antinociceptive effect.
Topics: Action Potentials; Analgesics; Animals; Anticonvulsants; Blood Pressure; Dose-Response Relationship, | 2010 |
In vitro and in vivo pharmacological characterization of two novel selective cannabinoid CB(2) receptor inverse agonists.
Topics: Analgesics; Animals; CHO Cells; Cricetinae; Cricetulus; Cyclohexanols; Drug Inverse Agonism; Formald | 2010 |
The cAMP response element-binding protein in the bed nucleus of the stria terminalis modulates the formalin-induced pain behavior in the female rat.
Topics: Animals; Behavior, Animal; Cyclic AMP Response Element-Binding Protein; Estradiol; Estrogens; Female | 2009 |
Formalin-induced short- and long-term modulation of Cav currents expressed in Xenopus oocytes: an in vitro cellular model for formalin-induced pain.
Topics: Animals; Calcium Channels; Cell Death; Disease Models, Animal; Female; Formaldehyde; Oocytes; Pain; | 2010 |
Interrelationship between measures of pain reactions in inflammation and levels of depression in prenatally stressed rat pups.
Topics: Analysis of Variance; Animals; Depression; Female; Formaldehyde; Inflammation; Male; Neuropsychologi | 2010 |
Acupuncture manipulation enhances anti-nociceptive effect on formalin-induced pain in rats.
Topics: Acupuncture Therapy; Animals; Formaldehyde; Gene Expression; Male; Needles; Pain; Pain Management; P | 2010 |
The antinociceptive and anti-inflammatory activities of Piptadenia stipulacea Benth. (Fabaceae).
Topics: Acetates; Acetic Acid; Animals; Anti-Inflammatory Agents; Brazil; Fabaceae; Flavonoids; Formaldehyde | 2010 |
The antinociceptive and anti-inflammatory activities of caulerpin, a bisindole alkaloid isolated from seaweeds of the genus Caulerpa.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capsaicin; Carrageenan; Caulerpa; Dose-Response Relat | 2009 |
Pharmacological evaluation of analgesic effects of the cholecystokinin2 receptor antagonist Z-360 in mouse models of formalin- and cancer-induced pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzodiazepinones; Cell Line, Tumor; Disease Model | 2010 |
Synergism between COX-3 inhibitors in two animal models of pain.
Topics: Acetaminophen; Animals; Cyclooxygenase Inhibitors; Dipyrone; Disease Models, Animal; Drug Synergism; | 2010 |
Expression genetics identifies spinal mechanisms supporting formalin late phase behaviors.
Topics: Animals; Anthracenes; Behavior, Animal; Enzyme Inhibitors; Fixatives; Formaldehyde; Gene Expression | 2010 |
Formalin-induced nociceptive behavior and c-Fos expression in middle-aged female rats.
Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Cell Count; Estradiol; Estrous Cycle; Female | 2010 |
Preliminary studies on the antinociceptive activity of Vaccinium ashei berry in experimental animal models.
Topics: Acetic Acid; Analgesics; Animals; Anthocyanins; Blueberry Plants; Diclofenac; Disease Models, Animal | 2010 |
Antinociceptive activity of aqueous extract of Bowdichia virgilioides in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Fabaceae; Formaldehyde; Male; Mice; Naloxone; Na | 2010 |
N-antipyrine-3, 4-dichloromaleimide, an effective cyclic imide for the treatment of chronic pain: the role of the glutamatergic system.
Topics: Administration, Oral; Analgesics; Animals; Antipyrine; Behavior, Animal; Carrageenan; Chronic Diseas | 2010 |
Systemic minocycline differentially influences changes in spinal microglial markers following formalin-induced nociception.
Topics: Animals; Antigens, CD1; Disease Models, Animal; Formaldehyde; Histocompatibility Antigens Class I; M | 2010 |
Blockade of tachykinin NK1/NK2 receptors in the brain attenuates the activation of corticotrophin-releasing hormone neurones in the hypothalamic paraventricular nucleus and the sympathoadrenal and pituitary-adrenal responses to formalin-induced pain in th
Topics: Animals; Blood Pressure; Brain; Corticotropin-Releasing Hormone; Formaldehyde; Heart Rate; Neurons; | 2010 |
Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress.
Topics: Animals; Avoidance Learning; Behavior, Animal; Foot; Formaldehyde; Ibotenic Acid; Male; Medulla Oblo | 2010 |
DNIC-mediated analgesia produced by a supramaximal electrical or a high-dose formalin conditioning stimulus: roles of opioid and alpha2-adrenergic receptors.
Topics: Adrenergic alpha-Antagonists; Afferent Pathways; Analgesia; Analysis of Variance; Animals; Area Unde | 2010 |
Antinociceptive effect of Zanthoxylum rhoifolium Lam. (Rutaceae) in models of acute pain in rodents.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Dizocilpine Maleate; Ethan | 2010 |
Analgesic properties of the novel amino acid, isovaline.
Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; beta-Alanine; Chronic Disease; Cisterna Magna; Fem | 2010 |
Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Diclofenac; Dose-Respons | 2010 |
Spinal antinociception of synthetic omega-conotoxin SO-3, a selective N-type neuronal voltage-sensitive calcium channel blocker, and its effects on morphine analgesia in chemical stimulus tests in rodent.
Topics: Acetic Acid; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Drug Interacti | 2010 |
Maternal separation stress leads to enhanced emotional responses to noxious stimuli in adult rats.
Topics: Aging; Analysis of Variance; Animals; Animals, Newborn; Arabidopsis Proteins; Emotions; Formaldehyde | 2010 |
The effects of acute restraint stress on nociceptive responses evoked by the injection of formalin into the temporomandibular joint of female rats.
Topics: Acute Disease; Animals; Behavior, Animal; Estrus; Female; Formaldehyde; Naltrexone; Narcotic Antagon | 2010 |
A diminished response to formalin stimulation reveals a role for the glutamate transporters in the altered pain sensitivity of mice with experimental autoimmune encephalomyelitis (EAE).
Topics: Amino Acid Sequence; Animals; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; F | 2010 |
Tumor tissue-derived formaldehyde and acidic microenvironment synergistically induce bone cancer pain.
Topics: Acids; Animals; Bone Neoplasms; Breast Neoplasms; CHO Cells; Cricetinae; Cricetulus; Female; Formald | 2010 |
Antinociceptive and anti-inflammatory activities of lectin from marine red alga Pterocladiella capillacea.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2010 |
Gene knockdown of the N-methyl-D-aspartate receptor NR1 subunit with subcutaneous small interfering RNA reduces inflammation-induced nociception in rats.
Topics: Animals; Formaldehyde; Freund's Adjuvant; Gene Knockdown Techniques; Inflammation Mediators; Injecti | 2010 |
[Formalin-induced pain stimulation induced expression of GABA in the distal cerebrospinal fluid contacting neurons].
Topics: Animals; Brain; Cerebrospinal Fluid; Formaldehyde; gamma-Aminobutyric Acid; Inflammation; Male; Neur | 2010 |
Effects of multiple intrathecal administration of L-arginine with different doses on formalin-induced nociceptive behavioral responses in rats.
Topics: Animals; Arginine; Behavior, Animal; Cell Count; Central Nervous System Agents; Dose-Response Relati | 2010 |
The analgesic effect and mechanism of the combination of sodium ferulate and oxymatrine.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Anti-Arrhythmia Agents; Anti-Inflammatory Agents, Non-S | 2010 |
Endogenous gonadal hormones regulate females' behavioral responses to formalin through prostaglandin E2 release.
Topics: Animals; Blotting, Western; Corticosterone; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Estrad | 2010 |
Antinociceptive effects of docosahexaenoic acid against various pain stimuli in mice.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Docosahexaenoic Acids; Dose-Response Relationshi | 2010 |
Antinociceptive and antiinflammatory activities of Adiantum latifolium Lam.: evidence for a role of IL-1β inhibition.
Topics: Acetic Acid; Adiantum; Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Behavior, An | 2011 |
Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior.
Topics: Amygdala; Analysis of Variance; Animals; Butadienes; Enzyme Inhibitors; Excitatory Amino Acid Antago | 2010 |
Dependency of nociception facilitation or inhibition after periaqueductal gray matter stimulation on the context.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Formaldehyde; | 2010 |
P2X4 receptors mediate PGE2 release by tissue-resident macrophages and initiate inflammatory pain.
Topics: Adoptive Transfer; Animals; Arachidonic Acid; Behavior, Animal; Carrageenan; Dinoprostone; Fixatives | 2010 |
The effect of intra-locus coeruleus injection of 17beta-estradiol on inflammatory pain modulation in male rat.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Bicuculline; Disease Models, Animal; Estradiol; Estro | 2010 |
Analgesic and antipyretic effects of Sansevieria trifasciata leaves.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Female; Fever; Form | 2009 |
Antinociceptive effect of butyl (2-phenylethynyl) selenide on formalin test in mice: Evidences for the involvement of serotonergic and adenosinergic systems.
Topics: Administration, Oral; Analgesics; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; | 2010 |
Remarkably long-lasting tachyphylaxis of pain responses to ET-1: evidence against central nervous system involvement.
Topics: Anesthetics; Animals; Central Nervous System; Endothelin A Receptor Antagonists; Endothelin-1; Foot; | 2010 |
Analgesic effects of the ethanolic extract from Magnolia ovata (Magnoliaceae) trunk bark and of N-acetylxylopine, a semi-synthetic analogue of xylopine.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Aporphines; Carrageenan; Disease Models, | 2011 |
A comparative chemical and pharmacological study of standardized extracts and vanillic acid from wild and cultivated Amburana cearensis A.C. Smith.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Capillary Permeability; Carrageenan; Dextrans; Edema; | 2011 |
Antinociceptive effect of vinpocetine--a comprehensive survey.
Topics: Acid Phosphatase; Analgesics; Animals; Calcitonin Gene-Related Peptide; Densitometry; Formaldehyde; | 2010 |
Involvement of kappa opioid receptors in the formalin-induced inhibition of analgesic tolerance to morphine via suppression of conventional protein kinase C activation.
Topics: Analgesics, Opioid; Animals; Brain; Chronic Disease; Disease Models, Animal; Down-Regulation; Drug T | 2010 |
Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability.
Topics: Action Potentials; Acyclic Monoterpenes; Aldehydes; Analgesics; Animals; Capsaicin; Facial Pain; For | 2010 |
Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Benzazepines; Dose-Response Relationshi | 2010 |
Antinociceptive and anti-inflammatory effects of Costus spicatus in experimental animals.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Costus; Disease Models, Ani | 2010 |
Tuberoinfundibular peptide of 39 residues (TIP39) signaling modulates acute and tonic nociception.
Topics: Amidohydrolases; Animals; Cannabinoid Receptor Modulators; Formaldehyde; In Situ Hybridization; Inje | 2010 |
Differential distribution of activated spinal neurons containing glycine and/or GABA and expressing c-fos in acute and chronic pain models.
Topics: Animals; Capsaicin; Cell Count; Disease Models, Animal; Formaldehyde; gamma-Aminobutyric Acid; Gene | 2010 |
Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors.
Topics: Animals; Behavior, Animal; Caspases; Disease Models, Animal; Dose-Response Relationship, Drug; Forma | 2010 |
Bioassay-guided evaluation of antioxidant and antinociceptive activities of carvacrol.
Topics: Analgesics; Animals; Antioxidants; Capsaicin; Cymenes; Drug Evaluation; Formaldehyde; Male; Mice; Mo | 2010 |
Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Carragee | 2010 |
Endogenous N-acetylaspartylglutamate (NAAG) inhibits synaptic plasticity/transmission in the amygdala in a mouse inflammatory pain model.
Topics: Amygdala; Animals; Behavior, Animal; Dipeptides; Disease Models, Animal; Excitatory Postsynaptic Pot | 2010 |
Antiinflammatory, analgesic and antipyretic activities of ethanolic root extract of Croton zambesicus.
Topics: Acetic Acid; Amphetamine; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal | 2010 |
A series of D-amino acid oxidase inhibitors specifically prevents and reverses formalin-induced tonic pain in rats.
Topics: Animals; Benzoic Acid; D-Amino-Acid Oxidase; Enzyme Inhibitors; Formaldehyde; Isoxazoles; Male; Pain | 2011 |
Antinociceptive activity of Hypericum grandifolium Choisy in mice.
Topics: Acetic Acid; Analgesics; Animals; Benzophenones; Chromatography, High Pressure Liquid; Female; Flavo | 2011 |
Bioassay-guided evaluation of antinociceptive effect of N-salicyloyltryptamine: a behavioral and electrophysiological approach.
Topics: Acetic Acid; Action Potentials; Analgesics; Animals; Behavior, Animal; Biological Assay; Diazepam; E | 2010 |
Aromatase and 5-alpha reductase gene expression: modulation by pain and morphine treatment in male rats.
Topics: Animals; Aromatase; Behavior, Animal; Brain; Cholestenone 5 alpha-Reductase; Formaldehyde; Gene Expr | 2010 |
Inter-strain differences of serotonergic inhibitory pain control in inbred mice.
Topics: Animals; Chronic Disease; Disease Models, Animal; Formaldehyde; Ganglia, Spinal; Hyperalgesia; Infla | 2010 |
Morphine exposure in early life increases nociceptive behavior in a rat formalin tonic pain model in adult life.
Topics: Age Factors; Analgesics, Opioid; Analysis of Variance; Anesthetics, Dissociative; Animals; Animals, | 2011 |
Antinociceptive and anti-inflammatory activities of ethyl acetate fraction from Zanthoxylum armatum in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Dose-Response Relation | 2011 |
The effect of depression on the thermal nociceptive thresholds in rats with spontaneous pain.
Topics: Animals; Body Weight; Depression; Disease Models, Animal; Escape Reaction; Formaldehyde; Hindlimb; H | 2010 |
Estradiol-induced antinociceptive responses on formalin-induced nociception are independent of COX and HPA activation.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Estradiol; Female; Formaldehyde; Hypothalamo-Hypophys | 2011 |
VGLUT2 expression in primary afferent neurons is essential for normal acute pain and injury-induced heat hypersensitivity.
Topics: Animals; Behavior, Animal; Capsaicin; Cold Temperature; Fixatives; Formaldehyde; Ganglia, Spinal; Ge | 2010 |
[Intrathecal injection of MK-801 inhibited the NOS activity and NO content of hippocampus in rat during the process of formalin-induced inflammatory pain].
Topics: Animals; Dizocilpine Maleate; Formaldehyde; Hippocampus; Inflammation; Injections, Spinal; Male; Nit | 2009 |
Anti-inflammatory and analgesic activity of different extracts of Commiphora myrrha.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Commiphora; Dinoprosto | 2011 |
[Formalin-induced pain enhanced nitric oxide synthase expression and nitric oxide production in the rat hippocampus].
Topics: Animals; Formaldehyde; Hippocampus; Inflammation; Male; Nitric Oxide; Nitric Oxide Synthase; Pain; P | 2007 |
Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Anti-Inflammatory Agents; Cyclooxygenase Inhibitors; Dose- | 2011 |
Increase in formalin-induced tonic pain by 5alpha-reductase and aromatase inhibition in female rats.
Topics: 5-alpha Reductase Inhibitors; Analgesics, Opioid; Animals; Aromatase Inhibitors; Drug Synergism; Fem | 2011 |
Antinociceptive effect of extract of Emilia sonchifolia in mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Asteraceae; Behavior, Animal; Brazil; Disease Models, Anim | 2011 |
Increases in mRNA and DREAM protein expression in the rat spinal cord after formalin induced pain.
Topics: Animals; Enkephalins; Formaldehyde; Humans; Immunohistochemistry; Kv Channel-Interacting Proteins; M | 2011 |
[Formalin inflammatory pain induced hippocampal neuronal apoptosis of rats].
Topics: Animals; Apoptosis; Formaldehyde; Hippocampus; Inflammation; Male; Neurons; Pain; Random Allocation; | 2009 |
[Activation of periphery group III metabotropic glutamate receptors inhibits formalin-induced activation of spinal p38-MAPK in rats].
Topics: Animals; Formaldehyde; Male; Nociception; p38 Mitogen-Activated Protein Kinases; Pain; Phosphoserine | 2009 |
[The effect of formalin-induced pain on CCK in rat spinal cord neurons].
Topics: Animals; Cholecystokinin; Female; Formaldehyde; Male; Neurons; Pain; Random Allocation; Rats; Rats, | 2009 |
[Effect of CGRP receptor antagonist CGRP8-37 on nociceptive response, NOS expression and NO content in the dorsal horn of spinal cord during formalin-induced inflammatory pain in rats].
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Form | 2004 |
[Changes of COX-2 expression in the dorsal horn of the spinal cord during formalin-induced inflammatory pain and hyperalgesia in rats].
Topics: Animals; Cyclooxygenase 2; Formaldehyde; Pain; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Spi | 2004 |
Long-term gender behavioral vulnerability after nociceptive neonatal formalin stimulation in rats.
Topics: Age Factors; Animals; Animals, Newborn; Anxiety; Exploratory Behavior; Female; Formaldehyde; Male; M | 2011 |
Ventrolateral periaqueductal gray lesion attenuates nociception but does not change anxiety-like indices or fear-induced antinociception in mice.
Topics: Animals; Anxiety; Behavior, Animal; Excitatory Amino Acid Agonists; Fear; Formaldehyde; Male; Maze L | 2011 |
RNA interference-mediated gene silence of the NR1 subunit of the NMDA receptor by subcutaneous injection of vector-encoding short hairpin RNA reduces formalin-induced nociception in the rat.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spinal; Ge | 2011 |
Effect of inhibition of spinal cord glutamate transporters on inflammatory pain induced by formalin and complete Freund's adjuvant.
Topics: Amino Acid Transport System X-AG; Animals; Aspartic Acid; Blotting, Western; Disease Models, Animal; | 2011 |
Central CRH administration changes formalin pain responses in male and female rats.
Topics: Animals; Brain; Corticotropin-Releasing Hormone; Female; Formaldehyde; Injections, Intraventricular; | 2011 |
Psychopharmacological properties of an aqueous extract of Tetracarpidium conophorum Hutch. & Dalziel in mice.
Topics: Acetic Acid; Alkaloids; Amphetamine; Animals; Antidepressive Agents; Euphorbiaceae; Female; Formalde | 2011 |
Effects induced by Apis mellifera venom and its components in experimental models of nociceptive and inflammatory pain.
Topics: Analysis of Variance; Animals; Bee Venoms; Formaldehyde; Inflammation; Male; Melitten; Mice; Motor A | 2011 |
Anti-inflammatory properties of doxycycline and minocycline in experimental models: an in vivo and in vitro comparative study.
Topics: alpha-Tocopherol; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Biphenyl Compounds | 2011 |
Analgesic and anti-inflammatory effects of the amphibian neurotoxin, anntoxin.
Topics: Acetic Acid; Amphibian Proteins; Animals; Behavior, Animal; Carrageenan; Cyclooxygenase 2; Cyclooxyg | 2011 |
Antinociceptive effects of methyl jasmonate in experimental animals.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Cyclopentanes; Female; Formaldehyde; Male; Mice; Oxylipi | 2011 |
Receptors involved in the antinociception of intrathecal melatonin in formalin test of rats.
Topics: Animals; Central Nervous System Depressants; Formaldehyde; Injections, Spinal; Irritants; Male; Mela | 2011 |
[Effect of intrathecal ketamine injection on protein kinase C expression in the spinal dorsal horn of rats with formalin-induced pain].
Topics: Animals; Formaldehyde; Injections, Spinal; Ketamine; Male; Pain; Pain Measurement; Posterior Horn Ce | 2011 |
Synthesis and determination of acute and chronic pain activities of 1-[1-(4-methylphenyl) (cyclohexyl)] morpholine as a new phencyclidine derivative in rats.
Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; Chronic Disease; Excitatory Amino Acid Antagonists | 2011 |
Synergistic interaction between intrathecal ginsenosides and morphine on formalin-induced nociception in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, | 2011 |
Analgesic and anti-inflammatory property of the methanol extract from Ligustrum morrisonense leaves in rodents.
Topics: Abdomen; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillary Permeability; Ca | 2011 |
Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Biomarkers; Blood Glucose; Body W | 2011 |
The endocannabinoid system in the rat dorsolateral periaqueductal grey mediates fear-conditioned analgesia and controls fear expression in the presence of nociceptive tone.
Topics: Analgesia; Animals; Cannabinoid Receptor Modulators; Conditioning, Psychological; Endocannabinoids; | 2012 |
Antinociceptive effect of cyclic phosphatidic acid and its derivative on animal models of acute and chronic pain.
Topics: Acute Disease; Anesthesia; Animals; Behavior, Animal; Chronic Disease; Cyclic P-Oxides; Disease Mode | 2011 |
Chemical study and anti-inflammatory, analgesic and antioxidant activities of the leaves of Aristotelia chilensis (Mol.) Stuntz, Elaeocarpaceae.
Topics: Administration, Topical; Alkaloids; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents; Antiox | 2011 |
Activation of metabotropic glutamate receptor 7 in spinal cord inhibits pain and hyperalgesia in a novel formalin model in sheep.
Topics: Aminobutyrates; Animals; Behavior, Animal; Benzhydryl Compounds; Disease Models, Animal; Dose-Respon | 2011 |
Preemptive analgesic effects of midazolam and diclofenac in rat model.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Diclofenac; Disease Models, Animal; Fo | 2011 |
Inhibition of TRPA1 channel activity in sensory neurons by the glial cell line-derived neurotrophic factor family member, artemin.
Topics: Animals; Ankyrins; Behavior, Animal; Calcium Channels; Formaldehyde; Ganglia, Spinal; Glial Cell Lin | 2011 |
Identification of a potent, state-dependent inhibitor of Nav1.7 with oral efficacy in the formalin model of persistent pain.
Topics: Acetamides; Administration, Oral; Analgesics; Animals; Binding Sites; Cell Line; ERG1 Potassium Chan | 2011 |
Triterpenes involved in the anti-inflammatory effect of ethanolic extract of Pterodon emarginatus Vogel stem bark.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Chemical Fractionation; Croton Oil; Dise | 2012 |
Ameliorative effect of caffeic acid against inflammatory pain in rodents.
Topics: Acetates; Animals; Behavior, Animal; Caffeic Acids; Carrageenan; Formaldehyde; Inflammation; Lipopol | 2011 |
Antinociceptive activity of discretamine isolated from Duguetia moricandiana.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Annonaceae; Berberine Alkaloids; Chromatogra | 2011 |
Interaction of histamine and calcitonin gene-related peptide in the formalin induced pain perception in rats.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antag | 2011 |
Molecular and electrophysiological changes in the prefrontal cortex-amygdala-dorsal periaqueductal grey pathway during persistent pain state and fear-conditioned analgesia.
Topics: Amygdala; Animals; Biophysics; Conditioning, Psychological; Disease Models, Animal; Electric Stimula | 2011 |
Analgesic effects and anti-inflammatory properties of the crude methanolic extract of Schwenckia americana Linn (Solanaceae).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Disease Models, Animal; Dose-Response Re | 2011 |
Analgesic effects and mechanisms of anti-inflammation of taraxeren-3-one from Diospyros maritima in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Catalase; Diospyros; Edema; | 2011 |
Intracellular pH in primary somatosensory neurons.
Topics: Animals; Female; Formaldehyde; Pain; Sodium-Hydrogen Exchangers; Spinal Cord | 2011 |
Role of the spinal Na+/H+ exchanger in formalin-induced nociception.
Topics: Amiloride; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Guanid | 2011 |
Poincaré plot descriptors of heart rate variability as markers of persistent pain expression in freely moving rats.
Topics: Algorithms; Animals; Body Temperature; Carrageenan; Disease Models, Animal; Formaldehyde; Heart Rate | 2011 |
Erythropoietin reduces neuronal cell death and hyperalgesia induced by peripheral inflammatory pain in neonatal rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain; Cell Death; Cerebrovascular Circula | 2011 |
Anti-inflammatory and analgesic activity of Alkanna bracteosa and Alkanna tricophila.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Boraginaceae; Carrageenan; Drug Evaluation, Preclinic | 2012 |
Topical anti-inflammatory and analgesic activity of kirenol isolated from Siegesbeckia orientalis.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Ast | 2011 |
Antioxidant, analgesic, and anti-inflammatory activities of the ethanolic extracts of Taxillus liquidambaricola.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Benzothiazoles; Biphenyl C | 2011 |
Antinociceptive and hypnotic properties of Celastrus orbiculatus.
Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; F | 2011 |
Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin.
Topics: Aconitine; Adjuvants, Anesthesia; Analgesics; Animals; Antihypertensive Agents; Atropine; Cobra Neur | 2011 |
Analgesic and anti-inflammatory activities of salicylaldehyde 2-chlorobenzoyl hydrazone (H(2)LASSBio-466), salicylaldehyde 4-chlorobenzoyl hydrazone (H(2)LASSBio-1064) and their zinc(II) complexes.
Topics: Acetic Acid; Aldehydes; Analgesics; Animals; Anti-Inflammatory Agents; Coordination Complexes; Cryst | 2011 |
Anterior cingulate cortex is crucial for contra- but not ipsi-lateral electro-acupuncture in the formalin-induced inflammatory pain model of rats.
Topics: Analgesics; Animals; Disease Models, Animal; Electroacupuncture; Formaldehyde; Gyrus Cinguli; Inflam | 2011 |
Anti-inflammatory and antinociceptive effects of the stem bark of Byrsonima intermedia A. Juss.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Chromatography, High P | 2011 |
Environmentally induced antinociception and hyperalgesia in rats and mice.
Topics: Analysis of Variance; Animals; Environment; Female; Formaldehyde; Hyperalgesia; Male; Maze Learning; | 2011 |
Chemical stimulation of the ST36 acupoint reduces both formalin-induced nociceptive behaviors and spinal astrocyte activation via spinal alpha-2 adrenoceptors.
Topics: Acupuncture Points; Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Astrocytes; Bee Ve | 2011 |
Group II/III metabotropic glutamate receptors exert endogenous activity-dependent modulation of TRPV1 receptors on peripheral nociceptors.
Topics: Amino Acids; Animals; Calcium; Capsaicin; Cells, Cultured; Cytosol; Excitatory Amino Acid Agonists; | 2011 |
Analgesic effects of cannabinoid receptor agonist WIN55,212-2 in the nucleus cuneiformis in animal models of acute and inflammatory pain in rats.
Topics: Analgesics; Analysis of Variance; Animals; Area Under Curve; Benzoxazines; Cannabinoid Receptor Agon | 2011 |
Activation of spinal mu- and delta-opioid receptors potently inhibits substance P release induced by peripheral noxious stimuli.
Topics: Animals; Capsaicin; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Formaldehyde; Injections, Spinal; Male; Mic | 2011 |
Post-conditioning experience with acute or chronic inflammatory pain reduces contextual fear conditioning in the rat.
Topics: Acoustic Stimulation; Animals; Conditioning, Classical; Cues; Disease Models, Animal; Fear; Formalde | 2012 |
Fear-induced suppression of nociceptive behaviour and activation of Akt signalling in the rat periaqueductal grey: role of fatty acid amide hydrolase.
Topics: Amidohydrolases; Analgesia; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Cannabinoid Re | 2012 |
D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain.
Topics: Analgesics; Animals; Behavior, Animal; D-Amino-Acid Oxidase; Formaldehyde; Hydrogen Peroxide; Hypera | 2012 |
Suppressive effects of glycyrrhetinic acid derivatives on tachykinin receptor activation and hyperalgesia.
Topics: Analgesics; Animals; Calcium; Capsaicin; CHO Cells; Cricetinae; Disease Models, Animal; Formaldehyde | 2011 |
Nociceptive stimuli enhance anesthetic-induced neuroapoptosis in the rat developing brain.
Topics: Anesthetics, Inhalation; Animals; Animals, Newborn; Apoptosis; Behavior, Animal; Blotting, Western; | 2012 |
[Effects of nitric oxide on spontaneous pain reaction and neuronal apoptosis in the spinal cord of rats induced by formalin inflammatory pain].
Topics: Animals; Apoptosis; Formaldehyde; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric | 2011 |
Subacute arsenic exposure through drinking water reduces the pharmacodynamic effects of ketoprofen in male rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arsenites; Carrageenan; Cycl | 2012 |
Analgesic, anti-inflammatory, and CNS depressant activities of new constituents of Nepeta clarkei.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Behavior, Animal; | 2012 |
Influence of memantine on nociceptive responses of the trigeminocervical complex after formalin injection.
Topics: Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Immunohistochemistry; Irritants; Male; Mem | 2012 |
Pain threshold variations in female rats as a function of the estrus cycle.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Estrous Cycle; Female; Formaldehyde; Hot Temperat | 2011 |
Anti-nociceptive and anti-inflammatory properties of the ethanolic extract of Lagenaria breviflora whole fruit in rat and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cucurbitaceae; Disease Mode | 2011 |
Pharmacological and pharmacokinetic studies with agaricoglycerides, extracted from Grifola frondosa, in animal models of pain and inflammation.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Formaldehyde; Grifola; Inflammation | 2012 |
Influence of susceptibility to hydrolysis and hydrophobicity of arylsemicarbazones on their anti-nociceptive and anti-inflammatory activities.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Formaldehyde; Hydrolysis; Hydroph | 2012 |
The combined predictive capacity of rat models of algogen-induced and neuropathic hypersensitivity to clinically used analgesics varies with nociceptive endpoint and consideration of locomotor function.
Topics: Amines; Analgesics; Animals; Capsaicin; Cyclohexanecarboxylic Acids; Disease Models, Animal; Duloxet | 2012 |
Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents.
Topics: Acetic Acid; Administration, Oral; Alkaloids; Analgesics; Analgesics, Opioid; Animals; Asteraceae; B | 2012 |
Synthesis and study the analgesic effects of new analogues of ketamine on female wistar rats.
Topics: Analgesics; Animals; Female; Formaldehyde; Ketamine; Molecular Structure; Pain; Rats; Rats, Wistar | 2012 |
Reduction of inflammatory pain in female rats after NR2B NMDA cortical antagonism.
Topics: Animals; Drug Evaluation, Preclinical; Estrous Cycle; Excitatory Amino Acid Antagonists; Female; For | 2012 |
The involvement of the spinal release of glutamate and nitric oxide in peripheral noxious stimulation-induced pain-related behaviors--study in mouse spinal microdialysis.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Glutamic Acid; Male; Mice; Microdialysis; Nitric | 2012 |
The activation of urocortin immunoreactive neurons in the Einger-Westphal nucleus following stress in rats.
Topics: Acute Disease; Animals; Disease Models, Animal; Fluorescent Antibody Technique; Formaldehyde; Immuno | 2001 |
Acute effect of essential oil of Eugenia caryophyllata on cognition and pain in mice.
Topics: Analgesics; Animals; Cognition; Formaldehyde; Male; Maze Learning; Memory Disorders; Mice; Neuroprot | 2012 |
Inhibition of morphine tolerance is mediated by painful stimuli via central mechanisms.
Topics: Analgesics, Opioid; Animals; Corticosterone; Disease Models, Animal; Dose-Response Relationship, Dru | 2012 |
Effect of spinally administered simvastatin on the formalin-induced nociceptive response in mice.
Topics: Analgesics; Animals; Formaldehyde; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Injections, Spina | 2012 |
Down-regulation of spinal D-amino acid oxidase expression blocks formalin-induced tonic pain.
Topics: Analgesia; Animals; Astrocytes; D-Amino-Acid Oxidase; Down-Regulation; Epithelial Cells; Formaldehyd | 2012 |
Adult-age inflammatory pain experience enhances long-term pain vigilance in rats.
Topics: Animals; Anticipation, Psychological; Behavior, Animal; Chronic Disease; Conditioning, Psychological | 2012 |
Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
Topics: Acetic Acid; Administration, Oral; Animals; Asteraceae; Carbazoles; Cyclic GMP-Dependent Protein Kin | 2012 |
Evaluation of the antinociceptive, anti-inflammatory and gastric antiulcer activities of the essential oil from Piper aleyreanum C.DC in rodents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Carrageenan; Ethanol; Formaldehyde | 2012 |
Antinociceptive activity of aqueous extract and isolated compounds of Lithrea molleoides.
Topics: Acetic Acid; Adrenergic alpha-2 Receptor Antagonists; Anacardiaceae; Analgesics; Animals; Behavior, | 2012 |
Anti-nociceptive and anti-inflammatory effects of Croton crassifolius ethanol extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Capillaries; Carrageen | 2012 |
Antinociceptive activity of methanol extract of flowers of Impatiens balsamina.
Topics: Acetic Acid; Analgesics; Animals; Flavonoids; Flowers; Formaldehyde; Hot Temperature; Impatiens; Met | 2012 |
Antinociceptive effects of intrathecal landiolol injection in a rat formalin pain model.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Injections, Spinal; Male; Morpholines; Pa | 2012 |
[Effect of formalin inflammatory pain on expression of HO-1 in spinal cord of rats].
Topics: Animals; Formaldehyde; Heme Oxygenase (Decyclizing); Male; Pain; Pain Measurement; Rats; Rats, Sprag | 2012 |
Analgesic and anti-inflammatory activities of the methanol extract of Elaeagnus oldhamii Maxim. in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Behavior, Animal; Carragee | 2012 |
Role of metabotropic glutamate receptor 1 in the basolateral amygdala-driven prefrontal cortical deactivation in inflammatory pain in the rat.
Topics: Action Potentials; Amygdala; Animals; Bicuculline; Carrageenan; Chromones; Disease Models, Animal; E | 2013 |
Isofraxidin exhibited anti-inflammatory effects in vivo and inhibited TNF-α production in LPS-induced mouse peritoneal macrophages in vitro via the MAPK pathway.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cells, Cultured; Coumarins; Edema; Fo | 2012 |
Nitric oxide modulated the expression of DREAM/calsenilin/KChIP3 in inflammatory pain of rats.
Topics: Animals; Formaldehyde; Inflammation; Injections, Spinal; Kv Channel-Interacting Proteins; Male; Morp | 2012 |
Antinociceptive effects of a chloroform extract and the alkaloid dicentrine isolated from fruits of Ocotea puberula.
Topics: Acetic Acid; Alkaloids; Analgesics, Opioid; Animals; Aporphines; Chloroform; Dose-Response Relations | 2012 |
Over-expression of endothelin-1 in astrocytes, but not endothelial cells, ameliorates inflammatory pain response after formalin injection.
Topics: Adrenomedullin; Animals; Astrocytes; Behavior, Animal; Calcitonin Gene-Related Peptide; Calcitonin R | 2012 |
Acute effect of Aloe vera gel extract on experimental models of pain.
Topics: Aloe; Animals; Cyclooxygenase 2 Inhibitors; Emollients; Formaldehyde; Gels; Inflammation; Mice; Mode | 2012 |
[Long-term effects of stress in critical periods of development on reactivity of adult female rats].
Topics: Animals; Behavior, Animal; Corticosterone; Female; Formaldehyde; Immobilization; Pain; Pain Measurem | 2012 |
Anti-inflammatory and analgesic properties of the ethanolic extract of Cnidoscolus aconitifolius in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Disease M | 2011 |
Analgesic effects of a standardized bioflavonoid composition from Scutellaria baicalensis and Acacia catechu.
Topics: Acacia; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Catechin; Edema; Flavonoids; For | 2012 |
Geopropolis from Melipona scutellaris decreases the mechanical inflammatory hypernociception by inhibiting the production of IL-1β and TNF-α.
Topics: Acetic Acid; Analgesics; Animals; Bees; Behavior, Animal; Brazil; Carrageenan; Complex Mixtures; For | 2012 |
Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection.
Topics: Animals; Anti-Inflammatory Agents; Diterpenes, Clerodane; Formaldehyde; Hyperalgesia; Male; Mice; Mi | 2012 |
Venom's antinociceptive property in the primitive ant Dinoponera quadriceps.
Topics: Acetic Acid; Analgesics; Animals; Ants; Behavior, Animal; Carrageenan; Formaldehyde; Hot Temperature | 2012 |
Semi-mechanistic modeling of the interaction between the central and peripheral effects in the antinociceptive response to lumiracoxib in rats.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Female; | 2012 |
Evaluation of formalin-induced pain behavior and glutamate release in the spinal dorsal horn using in vivo microdialysis in conscious rats.
Topics: Animals; Formaldehyde; Glutamic Acid; Male; Microdialysis; Pain; Rats; Rats, Wistar; Spinal Cord | 2012 |
Anti-inflammatory and anti-nociceptive properties of Prunus padus.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Edema; Formaldehyde; H | 2012 |
Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: correlation with desensitization of α4β2* receptors.
Topics: Analgesics; Animals; Binding, Competitive; Cell Line; Cell Line, Tumor; Formaldehyde; HEK293 Cells; | 2012 |
Effects of repetitive exposure to pain and morphine treatment on the neonatal rat brain.
Topics: Age Factors; Animals; Animals, Newborn; Brain; Disease Models, Animal; Doublecortin Protein; Formald | 2013 |
Effect of lesions of A5 or A7 noradrenergic cell group or surgical transection of brainstem catecholamine pathways on plasma catecholamine levels in rats injected subcutaneously by formalin.
Topics: Adrenergic Neurons; Animals; Brain Stem; Epinephrine; Formaldehyde; Injections, Subcutaneous; Male; | 2012 |
Antinociceptive effects of radon inhalation on formalin-induced inflammatory pain in mice.
Topics: Administration, Inhalation; Air Pollutants, Radioactive; Analgesics; Animals; Behavior, Animal; Cell | 2013 |
Anti-nociceptive activity of Pereskia bleo Kunth. (Cactaceae) leaves extracts.
Topics: Acetic Acid; Analgesics; Animals; Apigenin; Behavior, Animal; Cactaceae; Formaldehyde; Male; Mice; P | 2012 |
Anti-inflammatory and antinociceptive activities of the ethanolic extract of Bougainvillea xbuttiana.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Carrageenan; Cytokines | 2012 |
The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Analgesics; Animals; Butadienes; Cholinergic Agents; Dose-R | 2013 |
Antinociceptive activity of carvacrol (5-isopropyl-2-methylphenol) in mice.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Arginine; Behavior, Animal; Cymenes; Disease Model | 2012 |
Agaricus bisporus fucogalactan: structural characterization and pharmacological approaches.
Topics: Agaricus; Animals; Anti-Inflammatory Agents; Cyclooxygenase 2; Formaldehyde; Fungal Polysaccharides; | 2013 |
Low formalin concentrations induce fine-tuned responses that are sex and age-dependent: a developmental study.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Female; | 2013 |
Anti-inflammatory activity of ethanol extract and fractions from Couroupita guianensis Aublet leaves.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Cell Migration Assays, Leukocyte; Cell Su | 2013 |
Modulation of central nervous system-specific microRNA-124a alters the inflammatory response in the formalin test in mice.
Topics: Animals; Brain-Derived Neurotrophic Factor; Formaldehyde; Gene Expression Regulation; Gene Knockdown | 2013 |
Anti-inflammatory, analgesic, and antioxidant activities of Pisonia aculeata: folk medicinal use to scientific approach.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Carr | 2013 |
Studies on new cyclic imides obtained from aminophenazone with analgesic properties. Potent effects of a 3,4-dichloromaleimide derivative.
Topics: Acetic Acid; Aminopyrine; Analgesics, Non-Narcotic; Animals; Capsaicin; Formaldehyde; Imides; Indica | 2002 |
Group II mGluR receptor agonists are effective in persistent and neuropathic pain models in rats.
Topics: Animals; Ataxia; Chronic Disease; Excitatory Amino Acid Agonists; Formaldehyde; Injections, Intraper | 2002 |
Differential effects of NMDA and AMPA/KA receptor antagonists on c-Fos or Zif/268 expression in the rat spinal dorsal horn induced by noxious thermal or mechanical stimulation, or formalin injection.
Topics: 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; DNA-Binding Proteins; Dr | 2002 |
Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dantrolene; | 2002 |
Comparison of antiepileptic drugs tiagabine, lamotrigine, and gabapentin in mouse models of acute, prolonged, and chronic nociception.
Topics: Acetates; Acute Disease; Adrenergic alpha-Agonists; Amines; Analgesics, Non-Narcotic; Analgesics, Op | 2002 |
Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine.
Topics: Animals; Behavior, Animal; Dextromethorphan; Dose-Response Relationship, Drug; Edema; Excitatory Ami | 2002 |
Platelet-activating factor antagonists decrease the inflammatory nociceptive response in rats.
Topics: Animals; Azepines; Diterpenes; Dose-Response Relationship, Drug; Formaldehyde; Ginkgolides; Inflamma | 2002 |
Increase in testosterone metabolism in the rat central nervous system by formalin-induced tonic pain.
Topics: Animals; Brain; Central Nervous System; Enzyme Inhibitors; Finasteride; Formaldehyde; Male; Orchiect | 2002 |
Effects of the essential oil from citrus lemon in male and female rats exposed to a persistent painful stimulation.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Behavior, Animal; Chronic Disease; Citrus; Corticosterone; | 2002 |
Increased CNS uptake and enhanced antinociception of morphine-6-glucuronide in rats after inhibition of P-glycoprotein.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Behavior, Animal; Blotting, Wester | 2002 |
Effects of prenatal stress on formalin-induced acute and persistent pain in adult male rats.
Topics: Animals; Behavior, Animal; Female; Fetus; Formaldehyde; Male; Maternal Exposure; Pain; Pain Measurem | 2002 |
Endomorphin-2 is not released from rat spinal dorsal horn in response to intraplantar formalin.
Topics: Animals; Female; Formaldehyde; Genes, fos; Hindlimb; Male; Oligopeptides; Pain; Posterior Horn Cells | 2002 |
Participation of peripheral and spinal phosphodiesterases 4 and 5 in inflammatory pain.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic Nucleotide | 2002 |
Formalin-induced pain and mu-opioid receptor density in brain and spinal cord are modulated by A1 and A2a adenosine agonists in mice.
Topics: Adenosine; Animals; Autoradiography; Central Nervous System; Fixatives; Formaldehyde; Male; Mice; Mo | 2002 |
Antinociceptive and gastroprotective effects of diterpenes from the flower buds of Egletes viscosa.
Topics: Acetic Acid; Analgesics; Animals; Anti-Ulcer Agents; Asteraceae; Diterpenes; Dose-Response Relations | 2002 |
The role of contextual cues on counterirritation in the development process of analgesic tolerance to morphine.
Topics: Analgesics, Opioid; Animals; Conditioning, Operant; Cues; Dose-Response Relationship, Drug; Drug Tol | 2002 |
Effects of intracisternal injection of interleukin-6 on nociceptive jaw opening reflex and orofacial formalin test in freely moving rats.
Topics: Animals; Behavior, Animal; Electromyography; Formaldehyde; Hyperalgesia; Interleukin 1 Receptor Anta | 2003 |
Mechanisms involved in the antinociception caused by compound MV8612 isolated from Mandevilla velutina in mice.
Topics: Analgesics; Animals; Apamin; Bradykinin; Capsaicin; Charybdotoxin; Formaldehyde; Glyburide; Glycosid | 2003 |
Formalin- or adjuvant-induced peripheral inflammation increases neurokinin-1 receptor gene expression in the mouse.
Topics: Animals; Behavior, Animal; Formaldehyde; Freund's Adjuvant; Gene Expression; Hindlimb; Inflammation; | 2003 |
Maternal stress differently alters nociceptive behaviors in the formalin test in adult female and male rats.
Topics: Animals; Behavior, Animal; Female; Formaldehyde; Male; Pain; Pregnancy; Pregnancy Complications; Pre | 2003 |
Modulation of spinal nociceptive processing through the glutamate transporter GLT-1.
Topics: Analgesics, Opioid; Animals; Blotting, Western; Cell Culture Techniques; Dicarboxylic Acids; Excitat | 2003 |
Effects of morphine on formalin-induced nociception in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hindl | 2003 |
Functional magnetic resonance imaging of tonic pain and vasopressor effects in rats.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Brain Mapping; Cerebral Cortex; Cerebrovascular Circula | 2002 |
[MK-801 suppresses dynorphin A (1-17)-induced facilitation of nociceptive responses to formalin in rats].
Topics: Animals; Dizocilpine Maleate; Dynorphins; Formaldehyde; Injections, Spinal; Naloxone; Nociceptors; P | 2003 |
Antinociceptive effect in mice of intraperitoneal N-methyl-D-aspartate receptor antagonists in the formalin test.
Topics: Animals; Behavior, Animal; Dextromethorphan; Dizocilpine Maleate; Dose-Response Relationship, Drug; | 2003 |
Acute antinociceptive responses in single and combinatorial opioid receptor knockout mice: distinct mu, delta and kappa tones.
Topics: Animals; Disease Models, Animal; Female; Formaldehyde; Gene Deletion; Male; Mice; Mice, Inbred C57BL | 2003 |
Nitroglycerin induces hyperalgesia in rats--a time-course study.
Topics: Animals; Behavior, Animal; Formaldehyde; Hyperalgesia; Male; Nitroglycerin; Pain; Pain Measurement; | 2003 |
Anti-allodynic effect of NW-1029, a novel Na(+) channel blocker, in experimental animal models of inflammatory and neuropathic pain.
Topics: Amides; Animals; Ataxia; Behavior, Animal; Chronic Disease; Disease Models, Animal; Dose-Response Re | 2003 |
Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dextromethorphan; Dose-Response | 2003 |
Anti-inflammatory and antinociceptive activities of Loasa speciosa in rats and mice.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cornaceae; Dose-Response Relationship, D | 2003 |
The analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-St | 2003 |
Long-term ovariectomy changes formalin-induced licking in female rats: the role of estrogens.
Topics: Animals; Brain; Corticosterone; Estradiol; Estrogens; Female; Formaldehyde; Hindlimb; Hyperalgesia; | 2003 |
Antinociception with intrathecal alpha-methyl-5-hydroxytryptamine, a 5-hydroxytryptamine 2A/2C receptor agonist, in two rat models of sustained pain.
Topics: Animals; Behavior, Animal; Chronic Disease; Dose-Response Relationship, Drug; Formaldehyde; GABA-A R | 2003 |
Anti-inflammatory and antinociceptive activity of diphenyl diselenide.
Topics: Abdominal Muscles; Acetic Acid; Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Ste | 2003 |
Acupoint stimulation using bee venom attenuates formalin-induced pain behavior and spinal cord fos expression in rats.
Topics: Acupuncture Points; Animals; Bee Venoms; Dose-Response Relationship, Drug; Formaldehyde; Gene Expres | 2003 |
Lactoferrin enhances opioid-mediated analgesia via nitric oxide in the rat spinal cord.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Formaldehyde; Lactoferrin; Ma | 2003 |
Midazolam can potentiate the analgesic effects of intrathecal bupivacaine on thermal- or inflammatory-induced pain.
Topics: Anesthetics, Intravenous; Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Dose-Response | 2003 |
Supraspinal contribution to development of both tonic nociception and referred mirror hyperalgesia: a comparative study between formalin test and bee venom test in the rat.
Topics: Animals; Bee Venoms; Brain; Formaldehyde; Functional Laterality; Hindlimb; Hyperalgesia; Ibotenic Ac | 2003 |
Fos expression in tyrosine hydroxylase-containing neurons in rat brainstem after visceral noxious stimulation: an immunohistochemical study.
Topics: Animals; Brain Stem; Formaldehyde; Immunohistochemistry; Male; Neurons; Nociceptors; Pain; Proto-Onc | 2003 |
The algogenic-induced nociceptive flexion test in mice: studies on sensitivity of the test and stress on animals.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Bites and Stings; Bradykinin; Corticosterone; Dis | 2003 |
Fasting is a physiological stimulus of vagus-mediated enhancement of nociception in the female rat.
Topics: Adrenal Medulla; Adrenalectomy; Animals; Behavior, Animal; Estradiol; Fasting; Female; Formaldehyde; | 2003 |
Unaltered pain-related behavior in mice lacking NMDA receptor GluRepsilon 1 subunit.
Topics: Animals; Axotomy; Behavior, Animal; Blotting, Western; Formaldehyde; Freund's Adjuvant; Hindlimb; Ir | 2003 |
[Effect of essential oil of Radix Angelicae Dahuricae on beta-endorphin, ACTH, NO and proopiomelanocortin of pain model rats].
Topics: Adrenocorticotropic Hormone; Analgesics; Angelica; Animals; beta-Endorphin; Drugs, Chinese Herbal; F | 2002 |
Effects of TNF-alpha injected intracisternally on the nociceptive jaw-opening reflex and orofacial formalin test in freely moving rats.
Topics: Animals; Antineoplastic Agents; Cisterna Magna; Disease Models, Animal; Fixatives; Formaldehyde; Jaw | 2003 |
Differential patterns of c-fos mRNA expression in the amygdaloid nuclei induced by chemical somatic and visceral noxious stimuli in rats.
Topics: Acetic Acid; Amygdala; Animals; Formaldehyde; In Situ Hybridization; Inflammation; Male; Pain; Pain | 2003 |
A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain.
Topics: Animals; Binding Sites; Dependovirus; Excitatory Postsynaptic Potentials; Female; Formaldehyde; Gene | 2003 |
Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.
Topics: Amino Acid Sequence; Analgesics; Animals; Enkephalin, Methionine; Formaldehyde; Glycopeptides; Kidne | 2003 |
Antinociception induced by stimulation of ventrolateral periaqueductal gray at the freezing threshold is regulated by opioid and 5-HT2A receptors as assessed by the tail-flick and formalin tests.
Topics: Algorithms; Animals; Electric Stimulation; Formaldehyde; Ketanserin; Male; Microinjections; Naltrexo | 2003 |
A chronic-constriction injury of the sciatic nerve reduces bilaterally the responsiveness to formalin in rats: a behavioral and hormonal evaluation.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Cold Temperature; Corticosterone; Formaldehy | 2003 |
The effects of pyrilamine and cimetidine on mRNA C-fos expression and nociceptive flinching behavior in rats.
Topics: Animals; Behavior, Animal; Blotting, Northern; Cimetidine; Dose-Response Relationship, Drug; Formald | 2003 |
A role for peripheral somatostatin receptors in counter-irritation-induced analgesia.
Topics: Analgesia; Animals; Behavior, Animal; Capsaicin; Cell Count; Drug Administration Routes; Drug Intera | 2003 |
[Effect of Fos expression induced by spinal nitric oxide on the nociception of formalin in rats].
Topics: Animals; Behavior, Animal; Formaldehyde; Male; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pai | 2003 |
Analgesic and anti-inflammatory activity of the leaf essential oil of Laurus nobilis Linn.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dose-Response Relationship, Drug; Edem | 2003 |
The rodent amygdala contributes to the production of cannabinoid-induced antinociception.
Topics: Amygdala; Analgesics; Animals; Benzoxazines; Cannabinoids; Cell Count; Dose-Response Relationship, D | 2003 |
Antinociceptive effects of methysergide in various pain models.
Topics: Analgesia; Animals; Behavior, Animal; Formaldehyde; Injections, Intraperitoneal; Injections, Spinal; | 2003 |
Effects of direct periaqueductal grey administration of a cannabinoid receptor agonist on nociceptive and aversive responses in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cannabinoid Receptor Agonists; Disinfectants; Dose- | 2003 |
Antinociceptive profiles of crude extract from roots of Angelica gigas NAKAI in various pain models.
Topics: Administration, Oral; Analgesics; Angelica; Animals; Capsaicin; Cytokines; Excitatory Amino Acids; F | 2003 |
Role of thalamic phospholipase C[beta]4 mediated by metabotropic glutamate receptor type 1 in inflammatory pain.
Topics: Action Potentials; Animals; Behavior, Animal; Drug Administration Routes; Enzyme Inhibitors; Female; | 2003 |
[Thermoanalgesic properties of cortisone and ACTH; modification of pain reaction by histamine bichlorhydrate, cooling and formol].
Topics: Adrenocorticotropic Hormone; Body Temperature; Cold Temperature; Cortisone; Formaldehyde; Histamine; | 1952 |
Control of pain in rectal carcinoma; the use of intravenous polyvinylpyrrolidone and formaldehyde sulfoxylate therapy.
Topics: Administration, Intravenous; Formaldehyde; Humans; Pain; Povidone; Rectal Neoplasms; Rectum | 1957 |
Effects of intravenous Injections Paederiae and Stauntonia on spontaneous pain, hyperalgesia and inflammation induced by cutaneous chemical tissue injury in the rat.
Topics: Analgesics; Animals; Bee Venoms; Drugs, Chinese Herbal; Female; Formaldehyde; Hyperalgesia; Inflamma | 2003 |
Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: a behavioural and microdialysis study in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Synergism; Enzyme Inhibitors; Extracellular Flui | 2003 |
Involvement of NMDA receptors in Zif/268 expression in the trigeminal nucleus caudalis following formalin injection into the rat whisker pad.
Topics: Animals; Cell Count; Disease Models, Animal; Dizocilpine Maleate; DNA-Binding Proteins; Early Growth | 2003 |
Antinociceptive profile of (-)-spectaline: a piperidine alkaloid from Cassia leptophylla.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Capsaicin; Cassia; Dipyrone; Dose-Response Relationship | 2003 |
Nitrous oxide suppresses tonic and phasic nociceptive behaviors but not formalin-induced c-Fos expression in the rat spinal cord dorsal horn.
Topics: Anesthetics, Inhalation; Animals; Formaldehyde; Halothane; Immunohistochemistry; Nitrous Oxide; Pain | 2003 |
A new chloroquinolinyl chalcone derivative as inhibitor of inflammatory and immune response in mice and rats.
Topics: Abdominal Injuries; Administration, Oral; Animals; Arthritis, Experimental; Blood Platelets; Cell Li | 2003 |
NOS inhibitors exhibit antinociceptive properties in the rat formalin test.
Topics: Analgesics; Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Formaldehyde; Guanidines; Heart Ra | 2003 |
[Study on the mechanism of antinociception of intrathecal neostigmine in the formalin test in rats].
Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Male; Neostigmine; Nitric Oxide; Nociceptors; | 2003 |
Differential contributions of the basolateral and central nuclei of the amygdala in the negative affective component of chemical somatic and visceral pains in rats.
Topics: Acetic Acid; Affect; Amygdala; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psycholo | 2003 |
Beneficial actions of neurotrophin treatment on diabetes-induced hypoalgesia in mice.
Topics: Animals; Behavior, Animal; Blood Glucose; Body Weight; Cold Temperature; Diabetes Mellitus, Experime | 2003 |
Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat.
Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dinoprostone; Dose-Respons | 2004 |
The effects of exposure to repeated minor pain during the neonatal period on formalin pain behaviour and thermal withdrawal latencies.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Behavior, Animal; Disease Models, Anim | 2003 |
Reduction in [D-Ala2, NMePhe4, Gly-ol5]enkephalin-induced peripheral antinociception in diabetic rats: the role of the L-arginine/nitric oxide/cyclic guanosine monophosphate pathway.
Topics: Analgesics, Opioid; Animals; Arginine; Blood Glucose; Cyclic GMP; Diabetes Mellitus, Experimental; D | 2004 |
Adrenalectomy affects pain behavior of rats after formalin injection.
Topics: Adrenalectomy; Animals; Behavior, Animal; beta-Endorphin; Corticosterone; Formaldehyde; Injections, | 2004 |
Cholinergic modulation of nociceptive responses in vivo and neuropeptide release in vitro at the level of the primary sensory neuron.
Topics: Acetylcholine; Analysis of Variance; Animals; Arecoline; Atropine; Behavior, Animal; Bungarotoxins; | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain.
Topics: Analysis of Variance; Animals; Botulinum Toxins, Type A; Disease Models, Animal; Dose-Response Relat | 2004 |
Involvement of adenosine A1 receptors in forced walking stress-induced analgesia in mice.
Topics: Adenosine A1 Receptor Antagonists; Analgesia; Animals; Behavior, Animal; Formaldehyde; Male; Mice; M | 2003 |
Protein associated with Myc (PAM) is involved in spinal nociceptive processing.
Topics: Adaptor Proteins, Signal Transducing; Adenylyl Cyclases; Adrenergic beta-Agonists; Animals; Animals, | 2004 |
[Effect of prenatal stress upon parameters of the behavioral response induced by a tonic pain focus in male and female rats during postnatal ontogenesis].
Topics: Animals; Behavior, Animal; Female; Formaldehyde; Male; Pain; Pain Measurement; Pregnancy; Pregnancy | 2003 |
Protein kinase C epsilon and gamma: involvement in formalin-induced nociception in neonatal rats.
Topics: Animals; Animals, Newborn; Enzyme Inhibitors; Female; Formaldehyde; Gene Expression Regulation, Deve | 2004 |
Role of micro-opioid receptors in formalin-induced pain behavior in mice.
Topics: Animals; Behavior, Animal; Formaldehyde; Immunohistochemistry; Male; Mice; Mice, Knockout; Naloxone; | 2003 |
Ventricular arrhythmias triggered by alerting stimuli in conscious rabbits pre-treated with dofetilide.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adrenergic beta-Antagonists; Animals; Anti-Arr | 2004 |
Reduced inflammatory hyperalgesia with preservation of acute thermal nociception in mice lacking cGMP-dependent protein kinase I.
Topics: Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Disease Models, Animal; Formaldehyde; Hot | 2004 |
Selective amino acids changes in the medial and lateral preoptic area in the formalin test in rats.
Topics: Amino Acids; Analysis of Variance; Animals; Behavior, Animal; Brain Chemistry; Calcium; Electrophore | 2004 |
Effects of coadministration of cannabinoids and morphine on nociceptive behaviour, brain monoamines and HPA axis activity in a rat model of persistent pain.
Topics: Animals; Behavior, Animal; Biogenic Monoamines; Body Temperature; Brain; Brain Chemistry; Cannabidio | 2004 |
Antinociceptive effects of hydroalcoholic extract and essential oil of Zataria multiflora.
Topics: Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Injection | 2004 |
Nociception-driven decreased induction of Fos protein in ventral hippocampus field CA1 of the rat.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Gene Expression Regulation; Hippocampus; Ma | 2004 |
Intrathecal clonidine and bupivacaine have synergistic analgesia for acute thermally or inflammatory-induced pain in rats.
Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Clonidine; Do | 2004 |
Evaluation of the role of melatonin in formalin-induced pain response in mice.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Melatonin; Mice; Pain; Receptors, Adr | 2004 |
Effects of ketamine anesthesia on central nociceptive processing in the rat: a 2-deoxyglucose study.
Topics: Analysis of Variance; Anesthesia; Anesthetics, Dissociative; Animals; Behavior, Animal; Blood Glucos | 2004 |
Stimulus-dependent specificity for annexin 1 inhibition of the inflammatory nociceptive response: the involvement of the receptor for formylated peptides.
Topics: Animals; Annexin A1; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; | 2004 |
Formalin assay parameters differ in confirming the antinociceptive mechanism of domperidone in mice.
Topics: Analgesics; Animals; Disinfectants; Domperidone; Dopamine Antagonists; Drug Combinations; Formaldehy | 2004 |
Expression of c-Fos and NADPH-d after peripheral noxious stimulation in the pedunculopontine tegmental nucleus.
Topics: Animals; Formaldehyde; Genes, fos; Immunohistochemistry; Male; Mesencephalon; NADPH Dehydrogenase; N | 2004 |
Involvement of spinal lipoxygenase metabolites in hyperalgesia and opioid tolerance.
Topics: Analgesics, Opioid; Animals; Benzoquinones; Dose-Response Relationship, Drug; Drug Tolerance; Flavan | 2004 |
Pharmacological profile of parecoxib: a novel, potent injectable selective cyclooxygenase-2 inhibitor.
Topics: Acetic Acid; Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inh | 2004 |
Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Car | 2004 |
Analgesic and antiinflammatory activities of Erigeron floribundus.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Carrageenan; Dose-Response R | 2004 |
Analgesic properties of the aqueous and ethanol extracts of the leaves of Kalanchoe crenata (Crassulaceae).
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Formaldehyde; Hot Temper | 2004 |
[Characteristics of pain reaction and sensitivity in species of different genetic groups].
Topics: Animals; Behavior, Animal; Electric Stimulation; Formaldehyde; Genotype; Male; Mice; Mice, Inbred C5 | 2004 |
[Evaluation of analgesia evoked by microwaves of low intensity in the point of acupuncture in mice with different genotypes].
Topics: Acupuncture Points; Analgesia; Animals; Behavior, Animal; Formaldehyde; Genotype; Male; Mice; Mice, | 2004 |
Interaction of inducible nitric oxide synthase and cyclooxygenase-2 inhibitors in formalin-induced nociception in mice.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Rel | 2004 |
Metabotropic glutamate receptor 5 and dorsal raphe serotonin release in inflammatory pain in rat.
Topics: Animals; Carrageenan; Formaldehyde; Hindlimb; Inflammation; Male; Microdialysis; Pain; Pain Measurem | 2004 |
Analgesic and anti-inflammatory activities of a fraction rich in oncocalyxone A isolated from Auxemma oncocalyx.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anthraquinones; Anti-Inflammatory Agents; Boraginace | 2004 |
Corticothalamic modulation on formalin-induced change of VPM thalamic activities.
Topics: Animals; Bicuculline; Formaldehyde; GABA Agonists; GABA Antagonists; Male; Muscimol; Neural Pathways | 2004 |
Glutamate-evoked release of adenosine and regulation of peripheral nociception.
Topics: Adenosine; Adenosine A1 Receptor Agonists; Adenosine A1 Receptor Antagonists; alpha-Amino-3-hydroxy- | 2004 |
Effects of low-affinity NMDA receptor channel blockers in two rat models of chronic pain.
Topics: Animals; Chronic Disease; Dizocilpine Maleate; Electrophysiology; Excitatory Amino Acid Antagonists; | 2004 |
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats.
Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cycl | 2004 |
Direct evidence for the involvement of the mesolimbic kappa-opioid system in the morphine-induced rewarding effect under an inflammatory pain-like state.
Topics: Animals; Brain Chemistry; Conditioning, Operant; Dopamine; Dynorphins; Edema; Foot; Formaldehyde; In | 2005 |
Acute cardiac injury induces glial cell response and activates extracellular signaling-regulated kinase-1 and -2 in the spinal cord of Wistar rats.
Topics: Acute Disease; Animals; Enzyme Activation; Extracellular Fluid; Formaldehyde; Heart Diseases; Immuno | 2004 |
Diurnal changes of tonic nociceptive responses in mice: evidence for a proalgesic role of melatonin.
Topics: Animals; Autoradiography; Behavior, Animal; Binding Sites; Circadian Rhythm; Formaldehyde; Grooming; | 2004 |
Contributions of the anterior cingulate cortex and amygdala to pain- and fear-conditioned place avoidance in rats.
Topics: Amygdala; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psychological; Dose-Response | 2004 |
Acute and chronic ethanol exacerbates formalin pain in neonatal rats.
Topics: Age Factors; Animals; Animals, Newborn; Behavior, Animal; Central Nervous System Depressants; Drug A | 2004 |
Inhibitory effect of pranidipine on N-type voltage-dependent Ca2+ channels in mice.
Topics: Animals; Animals, Newborn; Behavior, Animal; Calcium; Calcium Channel Blockers; Calcium Channels, N- | 2004 |
Protein kinase C is partly involved in c-fos protein expression of nocuously-activated neurons but may not in concomitant modulatory action through opioid receptors at the spinal level in rats.
Topics: Animals; Formaldehyde; Immunohistochemistry; Male; Naloxone; Narcotic Antagonists; Nociceptors; Pain | 2004 |
Analgesic effect of TT-232, a heptapeptide somatostatin analogue, in acute pain models of the rat and the mouse and in streptozotocin-induced diabetic mechanical allodynia.
Topics: Acute Disease; Analgesics; Animals; Behavior, Animal; Benzoquinones; Diabetes Mellitus, Experimental | 2004 |
Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice.
Topics: Adaptation, Physiological; Animals; Dose-Response Relationship, Drug; Environment, Controlled; Forma | 2004 |
Amitriptyline produces multiple influences on the peripheral enhancement of nociception by P2X receptors.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Amitriptyline; Analgesics, Non-Narcotic; Anima | 2004 |
The analgesic and anti-inflammatory effects of subcutaneous bupivacaine, morphine and tramadol in rats.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Bupivacaine; Formaldehyde; Inflammation; Injections | 2004 |
Peripheral versus central antinociceptive actions of 6-amino acid-substituted derivatives of 14-O-methyloxymorphone in acute and inflammatory pain in the rat.
Topics: Acute Disease; Analgesics; Animals; Central Nervous System; Dose-Response Relationship, Drug; Fentan | 2005 |
NMDA-R1 antisense oligodeoxynucleotides modify formalin-induced nociception and spinal c-Fos expression in rat spinal cord.
Topics: Animals; Formaldehyde; Genes, fos; Immunohistochemistry; Male; Mutation, Missense; Oligodeoxyribonuc | 2004 |
An antisense oligonucleotide to the N-methyl-D-aspartate (NMDA) subunit NMDAR1 attenuates NMDA-induced nociception, hyperalgesia, and morphine tolerance.
Topics: Analgesics, Opioid; Animals; Autoradiography; Behavior, Animal; Dose-Response Relationship, Drug; Dr | 2005 |
Alterations in spinal cord gene expression after hindpaw formalin injection.
Topics: Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Functional La | 2004 |
Grafts of immortalized chromaffin cells bio-engineered to improve met-enkephalin release also reduce formalin-evoked c-fos expression in rat spinal cord.
Topics: Analysis of Variance; Animals; Cell Count; Cell Line, Transformed; Chromaffin Cells; Enkephalin, Met | 2004 |
Intrathecal propofol has analgesic effects on inflammation-induced pain in rats.
Topics: Analgesics; Animals; Disease Models, Animal; Formaldehyde; Hot Temperature; Inflammation; Injections | 2004 |
Effects of intrathecal BAM22 on noxious stimulus-evoked c-fos expression in the rat spinal dorsal horn.
Topics: Animals; Cattle; Cell Count; Drug Interactions; Enkephalin, Methionine; Enkephalins; Formaldehyde; G | 2004 |
Analgesic and anti-inflammatory activities of [6]-gingerol.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Catechols; Edema; Fatty Alc | 2005 |
Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities.
Topics: Acetic Acid; Animals; Carrageenan; Central Nervous System; Constriction, Pathologic; Edema; Formalde | 2004 |
The dorsal raphe nucleus as a site of action of the antinociceptive and behavioral effects of the alpha4 nicotinic receptor agonist epibatidine.
Topics: Analgesics; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocyclic; Dose-Response Relati | 2005 |
[Effect of tianyuan ketong recipe on the pain behavior, c-fos expression and P substance contents in dorsal horn of spinal cord in formalin induced pain model rats].
Topics: Analgesics, Non-Narcotic; Animals; Drugs, Chinese Herbal; Female; Formaldehyde; Immunohistochemistry | 2004 |
Peripheral effect of a kappa opioid receptor antagonist on nociception evoked by formalin injected in TMJ of pregnant rats.
Topics: Animals; Female; Formaldehyde; Naltrexone; Pain; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar; R | 2005 |
Antinociceptive properties of mixture of alpha-amyrin and beta-amyrin triterpenes: evidence for participation of protein kinase C and protein kinase A pathways.
Topics: Acetic Acid; Analgesics; Animals; Bradykinin; Cyclic AMP-Dependent Protein Kinases; Diterpenes; Dose | 2005 |
Effects of nociceptive stimuli on the pulmonary circulation in the ovine fetus.
Topics: Analgesics, Opioid; Animals; Blood Pressure; Fetus; Formaldehyde; Pain; Pulmonary Circulation; Sheep | 2005 |
Pre-versus post-formalin effects of intrathecal ketamine on spinal Fos-like immunoreactivity in rats.
Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Ketamine; Male; Neurons; Pain; Pain Measureme | 2004 |
Analgesic and antipyretic activities of the aqueous extract of Urtica macrorrhiza in experimental animals.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Animals; Dose-Response Rela | 2005 |
Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice.
Topics: Amygdala; Animals; Auditory Cortex; Behavior, Animal; Capsaicin; Conditioning, Classical; Excitatory | 2005 |
Antinociceptive effect of Teucrium polium leaf extract in the diabetic rat formalin test.
Topics: Analgesics; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Formaldehyde; Male | 2005 |
Intrathecal edaravone, a free radical scavenger, is effective on inflammatory-induced pain in rats.
Topics: Animals; Antipyrine; Behavior, Animal; Disease Models, Animal; Disinfectants; Dose-Response Relation | 2005 |
Preemptive effect of intravenous ketamine in the rat: concordance between pain behavior and spinal fos-like immunoreactivity.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Disease Models, Animal; Disinfectants; | 2005 |
Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae).
Topics: Acetic Acid; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non- | 2005 |
Formalin-induced pain is reduced in sigma(1) receptor knockout mice.
Topics: Animals; Behavior, Animal; Female; Formaldehyde; Genotype; Hindlimb; Injections, Subcutaneous; Male; | 2005 |
Functional magnetic resonance imaging studies of opioid receptor-mediated modulation of noxious-evoked BOLD contrast in rats.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Brain; Brain Mapping; Drug Interactions; Formalde | 2005 |
Antinociceptive action of aqueous extract of the leaves of Ixora coccinea.
Topics: Alanine Transaminase; Analgesics; Animals; Antioxidants; Aspartate Aminotransferases; Cell Membrane; | 2005 |
A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel transient receptor potential type V1 receptor antagonist, relieves pathophysiological pain associated with inflammation and tissue injury in rats.
Topics: Acute Disease; Analgesics; Animals; Capsaicin; Carrageenan; Chronic Disease; Dose-Response Relations | 2005 |
Inhibitory effects of a selective endothelin-A receptor antagonist YM598 on endothelin-1-induced potentiation of nociception in formalin-induced and prostate cancer-induced pain models in mice.
Topics: Administration, Oral; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Cell Line, Tumor; Disease | 2004 |
Analysis of the mechanism underlying the peripheral antinociceptive action of sildenafil in the formalin test.
Topics: Analgesics; Animals; Apamin; Charybdotoxin; Cyclic GMP-Dependent Protein Kinases; Dose-Response Rela | 2005 |
In vivo measurement of noradrenaline in the locus coeruleus of rats during the formalin test: a microdialysis study.
Topics: Animals; Formaldehyde; Locus Coeruleus; Male; Methoxyhydroxyphenylglycol; Microdialysis; Norepinephr | 2005 |
Endomorphin 1[psi] and endomorphin 2[psi], endomorphins analogues containing a reduced (CH2NH) amide bond between Tyr1 and Pro2, display partial agonist potency but significant antinociception.
Topics: Amides; Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Guinea Pigs; In | 2005 |
Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib.
Topics: Analgesics; Animals; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship | 2005 |
[Effect of intrathecal pumping morphine on immunological function in rats with formalin pain].
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Formaldehyde; Immunosuppressive Agent | 2005 |
Analgesic activity of the roots and leaves extracts of Calliandra portoricensis.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Fabaceae; | 2005 |
Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Atropine; Behavior, Animal; Capsaicin; Cat's Claw; Dose- | 2005 |
Effects of the high-efficacy 5-HT1A receptor agonist, F 13640 in the formalin pain model: a c-Fos study.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; Male; Morphine; | 2005 |
Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat.
Topics: Analysis of Variance; Animals; Baclofen; Cyclohexanols; Dose-Response Relationship, Drug; Drug Inter | 2005 |
Lacosamide displays potent antinociceptive effects in animal models for inflammatory pain.
Topics: Acetamides; Animals; Arthritis; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Dru | 2006 |
Hippocampal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression is decreased in rat models of pain and stress.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Disease Models, | 2005 |
Pharmacological evidence for the activation of Ca2+-activated K+ channels by meloxicam in the formalin test.
Topics: 4-Aminopyridine; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Apamin; Behavior, Animal; | 2005 |
Neuropeptide B-deficient mice demonstrate hyperalgesia in response to inflammatory pain.
Topics: Analysis of Variance; Animals; Body Weight; Formaldehyde; Hyperalgesia; In Situ Hybridization; Infla | 2005 |
Specificity of female and male sex hormones on excitatory and inhibitory phases of formalin-induced nociceptive responses.
Topics: Analysis of Variance; Animals; Castration; Female; Formaldehyde; Gonadal Steroid Hormones; Hormone R | 2005 |
Antinociceptive effects of the essential oil of Alpinia zerumbet on mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Dose-Response Relationsh | 2005 |
Endogenous opioid mechanisms partially mediate P2X3/P2X2/3-related antinociception in rat models of inflammatory and chemogenic pain but not neuropathic pain.
Topics: Analgesia; Animals; Arthritis, Experimental; Dose-Response Relationship, Drug; Endorphins; Formaldeh | 2005 |
c-Fos antisense oligodeoxynucleotide offsets behavioral nociceptive responses and both up-regulations of c-Fos protein and dynorphin a (1-8) in dorsal horn: a study using the formalin test in rats.
Topics: Animals; Behavior, Animal; Dynorphins; Female; Formaldehyde; Injections, Spinal; Male; Oligodeoxyrib | 2005 |
Antinociceptive effects of haloperidol and its metabolites in the formalin test in mice.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug | 2005 |
Antipyretic and analgesic activities of Caesalpinia bonducella seed kernel extract.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Animals; Body Temperature; | 2005 |
Peripheral participation of the phosphodiesterase 3 on formalin-evoked nociception.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Res | 2005 |
Lack of the nitric oxide-cyclic GMP-potassium channel pathway for the antinociceptive effect of intrathecal zaprinast in a rat formalin test.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Analgesics; Animals; Cyclic GMP; Formaldehyde; Glyburide; Injec | 2005 |
Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice.
Topics: Animals; Behavior, Animal; Carrageenan; Cisplatin; Disease Models, Animal; Formaldehyde; Hyperalgesi | 2005 |
GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cell Count; Formaldehyde; Gangliosides; Hot Tempera | 2005 |
Evaluation of interaction between intrathecal adenosine and MK801 or NBQX in a rat formalin pain model.
Topics: Adenosine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Disease Models, Animal | 2005 |
Intrathecal grafting of porcine chromaffin cells reduces formalin-evoked c-Fos expression in the rat spinal cord.
Topics: Animals; Behavior, Animal; Cattle; Chromaffin Cells; Fixatives; Formaldehyde; Male; Pain; Pain Manag | 2005 |
Ambroxol, a Nav1.8-preferring Na(+) channel blocker, effectively suppresses pain symptoms in animal models of chronic, neuropathic and inflammatory pain.
Topics: Ambroxol; Amines; Analgesics; Animals; Behavior, Animal; Constriction, Pathologic; Cyclohexanecarbox | 2005 |
Evaluation of the analgesic effect of Echium amoenum Fisch & C.A. Mey. extract in mice: possible mechanism involved.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Echium; Flowers; Formaldehyde; Hot Temperatur | 2006 |
Involvement of N-methyl-D-aspartate-type glutamate receptor epsilon1 and epsilon4 subunits in tonic inflammatory pain and neuropathic pain.
Topics: Animals; Formaldehyde; Inflammation; Ligation; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain; Pain | 2005 |
Intrathecally-administered histamine facilitates nociception through tachykinin NK1 and histamine H1 receptors: a study in histidine decarboxylase gene knockout mice.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Behavior, Animal; Capsaicin; Excitatory Amino Acid | 2005 |
Analgesic properties of the novel compound M43068 in rat models of acute and neuropathic pain.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Baclofen; Behavior, Animal; Disease Models, Anima | 2005 |
[Analgesic actions after local peripheral administration of Lornoxicam in a model of formalin test in the rat].
Topics: Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Formaldehyde; Male; Noci | 2005 |
Estradiol and progesterone differentially regulate formalin-induced nociception in ovariectomized female rats.
Topics: Analgesia; Analysis of Variance; Animals; Estradiol; Estrogen Antagonists; Female; Formaldehyde; Ova | 2006 |
Antinociceptive action of the extract and the flavonoid quercitrin isolated from Bauhinia microstachya leaves.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Animals; Bauhinia; Carrageenan; Constriction, Pathologic | 2005 |
Nitric oxide and c-Jun N-terminal kinase are involved in the development of dark neurons induced by inflammatory pain.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Immunohistochemistry; Inflammation; Irritan | 2006 |
Analgesic effects of morphine and loperamide in the rat formalin test: interactions with NMDA receptor antagonists.
Topics: Analgesics, Opioid; Animals; Excitatory Amino Acid Antagonists; Formaldehyde; Hot Temperature; Loper | 2005 |
Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats.
Topics: Analgesia; Animals; Blood Glucose; Body Weight; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Di | 2005 |
Structure-activity relationship study of 1,4-dihydropyridine derivatives blocking N-type calcium channels.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Dihydropyridines; Formaldehyde; Molecul | 2006 |
Visceral, inflammatory and neuropathic pain in glycine receptor alpha 3-deficient mice.
Topics: Acetic Acid; Animals; Formaldehyde; Inflammation; Irritants; Mice; Mice, Mutant Strains; Neuralgia; | 2005 |
Stellate ganglion block inhibits formalin-induced nociceptive responses: mechanism of action.
Topics: Analgesia; Anesthetics, Local; Animals; Autonomic Nerve Block; Behavior, Animal; Bupivacaine; Formal | 2005 |
[Change in pain reaction by combined action of nitric oxide modulators and low intensity electromagnetic field].
Topics: Animals; Animals, Outbred Strains; Combined Modality Therapy; Electromagnetic Fields; Enzyme Inhibit | 2005 |
An investigation of the analgesic and anti-inflammatory effects of Nigella sativa seed polyphenols.
Topics: Acetic Acid; Analgesia; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Croton Oil; Ear; | 2005 |
Synergistic antinociception between zaprinast and morphine in the spinal cord of rats on the formalin test.
Topics: Analgesics, Opioid; Animals; Dose-Response Relationship, Drug; Drug Synergism; Formaldehyde; Injecti | 2006 |
Impaired inflammatory pain and thermal hyperalgesia in mice expressing neuron-specific dominant negative mitogen activated protein kinase kinase (MEK).
Topics: Animals; Behavior, Animal; Butadienes; Enzyme Activation; Formaldehyde; Genes, Dominant; Hot Tempera | 2006 |
Sex differences in the responses of spinal wide-dynamic range neurons to subcutaneous formalin and in the effects of different frequencies of conditioning electrical stimulation.
Topics: Afferent Pathways; Animals; Conditioning, Psychological; Dose-Response Relationship, Drug; Electric | 2006 |
Systemic administration of minocycline inhibits formalin-induced inflammatory pain in rat.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Edema; Electrophysiology; Formaldehyde; G | 2006 |
Effects of ketamine on acute somatic nociception in wild-type and N-methyl-D-aspartate (NMDA) receptor epsilon1 subunit knockout mice.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Aci | 2006 |
Analgesic effects of intrathecally administered celecoxib, a cyclooxygenase-2 inhibitor, in the tail flick test and the formalin test in rats.
Topics: Analgesia; Analysis of Variance; Animals; Behavior, Animal; Celecoxib; Cyclooxygenase 2 Inhibitors; | 2006 |
Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons.
Topics: Action Potentials; Animals; Formaldehyde; Male; Pain; Physical Stimulation; Posterior Horn Cells; Ra | 2006 |
Antinociceptive properties of the ethanolic extract and of the triterpene 3beta,6beta,16beta-trihidroxilup-20(29)-ene obtained from the flowers of Combretum leprosum in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Capsaicin; Combretum; Endorphins; Flowers; Formaldehyde; | 2006 |
Formalin injection into knee joints of rats: pharmacologic characterization of a deep somatic nociceptive model.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde; GABA Agents; Histamine | 2006 |
Hippocampal theta state in relation to formalin nociception.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroencephalography; Fixatives; Form | 2006 |
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid An | 2006 |
Suppression of pain by exposure of acupuncture points to polarized light.
Topics: Acupuncture Points; Animals; Behavior, Animal; Foot; Formaldehyde; Male; Mice; Pain; Pain Threshold; | 2006 |
Antinociceptive and free radical scavenging activities of alkaloids isolated from Lindera angustifolia Chen.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Biphenyl Compounds; Dose-Response Relationship, Drug; F | 2006 |
Acute and chronic morphine alters formalin pain in neonatal rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration S | 2006 |
Botulinum neurotoxins and formalin-induced pain: central vs. peripheral effects in mice.
Topics: Analysis of Variance; Animals; Behavior, Animal; Botulinum Toxins; Disinfectants; Dose-Response Rela | 2006 |
Antinociceptive, antiedematogenic and antiangiogenic effects of benzaldehyde semicarbazone.
Topics: Animals; Benzaldehydes; Carrageenan; Edema; Formaldehyde; Hyperalgesia; Male; Mice; Neovascularizati | 2006 |
Anti-inflammatory and anti-nociceptive activities of Pluchea quitoc (DC.) ethanolic extract.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Anti-Inflammatory Agents; Asteraceae; Carrag | 2006 |
Sex differences in the effects of amiloride on formalin test nociception in mice.
Topics: Amiloride; Animals; Dose-Response Relationship, Drug; Estrogens; Female; Formaldehyde; Gonads; Hormo | 2006 |
Potent analgesic effects of a putative sodium channel blocker M58373 on formalin-induced and neuropathic pain in rats.
Topics: Analgesics; Animals; Cells, Cultured; Dose-Response Relationship, Drug; Formaldehyde; Ganglia, Spina | 2006 |
Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity.
Topics: Administration, Oral; Animals; Behavior, Animal; Calcium Channel Blockers; Calcium Channels, N-Type; | 2006 |
Analgesic activity of a non-peptide imidazolidinedione somatostatin agonist: in vitro and in vivo studies in rat.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Action Potentials; Analgesics; Analysis of Variance; Animals | 2006 |
Antinociceptive effects of tetrodotoxin (TTX) in rodents.
Topics: Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relation | 2006 |
Endogenous nociceptin/orphanin FQ signalling produces opposite spinal antinociceptive and supraspinal pronociceptive effects in the mouse formalin test: pharmacological and genetic evidences.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Benzimidazoles; Drug Interactions; Form | 2006 |
Enhancement of morphine antinociception with the peptide N-methyl-D-aspartate receptor antagonist [Ser1]-histogranin in the rat formalin test.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Dru | 2006 |
Role of kappa- and delta-opioid receptors in the antinociceptive effect of oxytocin in formalin-induced pain response in mice.
Topics: Analgesics; Animals; Behavior; Calcium Channel Blockers; Dose-Response Relationship, Drug; Formaldeh | 2006 |
Study on the antinociceptive effects of Thymus broussonetii Boiss extracts in mice and rats.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Naloxo | 2006 |
Anti-inflammatory and analgesic activity of the topical preparation of Verbena officinalis L.
Topics: Administration, Topical; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response R | 2006 |
Interferential therapy produces antinociception during application in various models of inflammatory pain.
Topics: Animals; Carrageenan; Disease Models, Animal; Edema; Fixatives; Formaldehyde; Hyperalgesia; Inflamma | 2006 |
Inhibitory role of supraspinal P2X3/P2X2/3 subtypes on nociception in rats.
Topics: Acetic Acid; Adenosine Triphosphate; Analgesics; Animals; Dose-Response Relationship, Drug; Formalde | 2006 |
The glutamate transporter GLAST is involved in spinal nociceptive processing.
Topics: Amino Acid Transport System X-AG; Animals; Formaldehyde; Glutamic Acid; Hyperalgesia; Male; Neurons; | 2006 |
Increased formalin-induced pain and expression of fos neurons in the lumbar spinal cord of prenatally stressed infant rats.
Topics: Animals; Animals, Newborn; Female; Formaldehyde; Lumbosacral Region; Neurons; Pain; Pain Measurement | 2006 |
Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test.
Topics: Analgesics; Analysis of Variance; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug | 2006 |
Animal behavior. Signs of empathy seen in mice.
Topics: Altruism; Animals; Behavior, Animal; Empathy; Formaldehyde; Mice; Motivation; Pain; Social Behavior | 2006 |
Social modulation of pain as evidence for empathy in mice.
Topics: Altruism; Animals; Behavior, Animal; Cues; Empathy; Female; Formaldehyde; Hot Temperature; Male; Mic | 2006 |
Analgesic activity of the methanolic extract and total alkaloids of Glaucium paucilobum.
Topics: Acetic Acid; Alkaloids; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; Hot Tem | 2006 |
Screening for pain phenotypes: analysis of three congenic mouse strains on a battery of nine nociceptive assays.
Topics: Animals; Artifacts; Chromosome Mapping; Female; Formaldehyde; Genotype; Hot Temperature; Male; Mice; | 2006 |
Spinal prostaglandin E receptors of the EP2 subtype and the glycine receptor alpha3 subunit, which mediate central inflammatory hyperalgesia, do not contribute to pain after peripheral nerve injury or formalin injection.
Topics: Animals; Formaldehyde; Hyperalgesia; Inflammation; Injections; Mice; Mice, Knockout; Neuralgia; Pain | 2006 |
Pharmacological correlation between the formalin test and the neuropathic pain behavior in different species with chronic constriction injury.
Topics: Animals; Behavior, Animal; Cold Temperature; Dose-Response Relationship, Drug; Formaldehyde; Gerbill | 2006 |
On the mechanism of carbamazepine-induced antinociception in the formalin test.
Topics: Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Behavior, Ani | 2006 |
Is protein kinase C (PKC) involved in nociception?
Topics: Alkaloids; Animals; Behavior, Animal; Benzophenanthridines; Enzyme Inhibitors; Formaldehyde; Functio | 2006 |
Propofol's effects on nociceptive behavior and spinal c-fos expression after intraplantar formalin injection in mice with a mutation in the gamma-aminobutyric acid-type(A) receptor beta3 subunit.
Topics: Animals; Formaldehyde; Immunohistochemistry; Mice; Pain; Propofol; Protein Subunits; Proto-Oncogene | 2006 |
Lack of reciprocity between opioid and 5-HT3 receptors for antinociception in rat spinal cord.
Topics: Analgesia; Analgesics, Opioid; Animals; Biguanides; Dose-Response Relationship, Drug; Formaldehyde; | 2006 |
Antinociceptive effects of heterotopic electroacupuncture in formalin-induced pain.
Topics: Acupuncture Analgesia; Analysis of Variance; Animals; Behavior, Animal; Electric Stimulation; Electr | 2006 |
Persistent pain produces stress-like alterations in hippocampal neurogenesis and gene expression.
Topics: Animals; Antimetabolites; Behavior, Animal; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Ch | 2006 |
Biphasic effect of apomorphine on rat nociception and effect of dopamine D2 receptor antagonists.
Topics: Analgesics; Animals; Apomorphine; Domperidone; Dopamine Agonists; Dopamine Antagonists; Dopamine D2 | 2006 |
Expression and colocalization of NADPH-diaphorase and Fos in the subnuclei of the parabrachial nucleus in rats following visceral noxious stimulation.
Topics: Analysis of Variance; Animals; Formaldehyde; Gene Expression; Immunohistochemistry; Male; Medulla Ob | 2006 |
Antioxidants attenuate multiple phases of formalin-induced nociceptive response in mice.
Topics: Acetylcysteine; Animals; Antioxidants; Behavior, Animal; Cyclic N-Oxides; Female; Formaldehyde; Inje | 2006 |
Antinociceptive and anti-inflammatory effects of Thespesia populnea bark extract.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; | 2007 |
Peripheral formalin injection induces long-lasting increases in cyclooxygenase 1 expression by microglia in the spinal cord.
Topics: Animals; Blotting, Western; Cyclooxygenase 1; Cyclooxygenase 2; Formaldehyde; Hindlimb; Immunohistoc | 2007 |
Characterization of the antinociceptive and anti-inflammatory activities of riboflavin in different experimental models.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Body Temperature; Carrageenan; Dose | 2006 |
Expression changes of cation chloride cotransporters in the rat spinal cord following intraplantar formalin.
Topics: Animals; Behavior, Animal; Foot; Formaldehyde; Hyperalgesia; Immunoblotting; Immunohistochemistry; I | 2006 |
Further studies on the antinociceptive action of aqueous seed extract of Aframomum melegueta.
Topics: Analgesics, Non-Narcotic; Animals; Female; Formaldehyde; Hot Temperature; Male; Medicine, African Tr | 2007 |
Antinociceptive activity of the pyranocoumarin seselin in mice.
Topics: Acetic Acid; Analgesics; Animals; Coumarins; Dose-Response Relationship, Drug; Formaldehyde; Hot Tem | 2006 |
[Intrathecal administration of HSV-I amplicon vector-mediated HPPE gene therapy of nocicepion in rats with formalin pain].
Topics: Animals; Enkephalins; Formaldehyde; Gene Transfer Techniques; Genetic Therapy; Genetic Vectors; Herp | 2006 |
[Effect of intrathecal katemine on the expression of nNOS in spinal dorsal horn in rats with formalin pain].
Topics: Analgesics; Animals; Formaldehyde; Injections, Spinal; Ketamine; Male; Nitric Oxide Synthase Type I; | 2006 |
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid.
Topics: Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-S | 2006 |
Identification of the alpha2-delta-1 subunit of voltage-dependent calcium channels as a molecular target for pain mediating the analgesic actions of pregabalin.
Topics: Amino Acid Sequence; Analgesics; Animals; Arginine; Autoradiography; Base Sequence; Calcium Channels | 2006 |
Involvement of the bed nucleus of the stria terminalis in the negative affective component of visceral and somatic pain in rats.
Topics: Acetic Acid; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Conditioning, Psyc | 2007 |
Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice.
Topics: Analysis of Variance; Animals; Benzhydryl Compounds; Benzoates; Carrageenan; Dinucleoside Phosphates | 2007 |
Descending serotonergic facilitation of spinal ERK activation and pain behavior.
Topics: Animals; Enzyme Activation; Foot; Formaldehyde; Hyperalgesia; Male; Mitogen-Activated Protein Kinase | 2006 |
Antiinflammatory activity of the aqueous leaf extract of Byrsocarpus coccineus.
Topics: Administration, Oral; Albumins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Conna | 2007 |
Effects of neonatal testosterone treatment on sex differences in formalin-induced nociceptive behavior in rats.
Topics: Analysis of Variance; Androgens; Animals; Animals, Newborn; Behavior, Animal; Castration; Female; Fo | 2007 |
Antiinflammatory and antiulcer properties of tannins from Myracrodruon urundeuva Allemão (Anacardiaceae) in rodents.
Topics: Administration, Oral; Anacardiaceae; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Ag | 2007 |
Antinociceptive effects of the aqueous extract of Brugmansia suaveolens flowers in mice.
Topics: Acetic Acid; Analgesics; Analysis of Variance; Animals; Diclofenac; Disease Models, Animal; Drug Eva | 2007 |
Impaired acute and inflammatory nociception in mice lacking the p50 subunit of NF-kappaB.
Topics: Animals; Cyclooxygenase 2; Formaldehyde; Hot Temperature; Inflammation; Mice; Mice, Knockout; NF-kap | 2007 |
Antinociceptive and antiinflammatory activities of pine (Pinus densiflora) pollen extract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arachidonic Acid; Carrageenan; Edema; Formaldehyde; M | 2007 |
Synthesis, pharmacological evaluation and electrochemical studies of novel 6-nitro-3,4-methylenedioxyphenyl-N-acylhydrazone derivatives: Discovery of LASSBio-881, a new ligand of cannabinoid receptors.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Arachidonic Acid; Arachidonic Acids; Bi | 2007 |
Activation of the extracellular signal-regulated kinase in the amygdala modulates pain perception.
Topics: Amygdala; Analysis of Variance; Animals; Behavior, Animal; Blotting, Western; Butadienes; Enzyme Act | 2007 |
The function neutralizing anti-TrkA antibody MNAC13 reduces inflammatory and neuropathic pain.
Topics: 3T3 Cells; Analgesics, Opioid; Animals; Antibodies, Monoclonal; Binding Sites, Antibody; Disease Mod | 2007 |
Sex differences in opioid-mediated pain inhibitory mechanisms during the interphase in the formalin test.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Castration; Dose-Response Relat | 2007 |
Analgesic and anti-inflammatory activities of a fraction rich in gaultherin isolated from Gaultheria yunnanensis (FRANCH.) REHDER.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carrageenan; Croton | 2007 |
Intrathecal landiolol inhibits nociception and spinal c-Fos expression in the mouse formalin test.
Topics: Adrenergic beta-Antagonists; Anesthesia, Spinal; Animals; Formaldehyde; Injections, Spinal; Male; Mi | 2007 |
Ligustilide attenuates pain behavior induced by acetic acid or formalin.
Topics: 4-Butyrolactone; Acetic Acid; Analgesics; Animals; Drugs, Chinese Herbal; Female; Formaldehyde; Medi | 2007 |
The protective role of testosterone in the development of temporomandibular joint pain.
Topics: Analysis of Variance; Androgens; Animals; Castration; Disease Models, Animal; Dose-Response Relation | 2007 |
Antinociceptive effect of intra-hippocampal CA1 and dentate gyrus injection of MK801 and AP5 in the formalin test in adult male rats.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dentate Gyrus; Dizocilpine Maleate; Excitatory Ami | 2007 |
The mechanisms of pain-induced pulmonary vasoconstriction: an experimental study in fetal lambs.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Catecholamines; Disease Models, Animal; Fetal | 2007 |
Altered response to formalin by L5 spinal nerve ligation in rats: a behavioral and molecular study.
Topics: Acute Disease; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Calcitonin Gene-Related | 2007 |
Transgenic glial nuclear factor-kappa B inhibition decreases formalin pain in mice.
Topics: Animals; Formaldehyde; Glial Fibrillary Acidic Protein; I-kappa B Proteins; Immunohistochemistry; In | 2007 |
Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647.
Topics: Analgesics; Animals; Arachidonic Acids; Behavior, Animal; Butyrates; Cannabinoid Receptor Agonists; | 2007 |
Antinociception of heterotopic electro-acupuncture mediated by the dorsolateral funiculus.
Topics: Acupuncture Points; Animals; Behavior, Animal; Electroacupuncture; Formaldehyde; Injections, Subcuta | 2007 |
Lonchocarpus sericeus lectin decreases leukocyte migration and mechanical hypernociception by inhibiting cytokine and chemokines production.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Cell Adhesion; Cell Movement; Cytokines; | 2007 |
Antinociceptive, anti-inflammatory and antipyretic properties of Melastoma malabathricum leaves aqueous extract in experimental animals.
Topics: Acetic Acid; Analgesics; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents; Carrageenan; C | 2006 |
Analgesic and antipyretic effects of Capparis zeylanica leaves.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Capparis; Dose-Response Relationship, Drug; Female; F | 2007 |
Alteration of cingulate long-term plasticity and behavioral sensitization to inflammation by environmental enrichment.
Topics: Animals; Behavior, Animal; Early Growth Response Protein 1; Environment; Excitatory Postsynaptic Pot | 2007 |
Highly activated c-fos expression in specific brain regions (ependyma, circumventricular organs, choroid plexus) of histidine decarboxylase deficient mice in response to formalin-induced acute pain.
Topics: Animals; Behavior, Animal; Brain; Cerebral Ventricles; Choroid Plexus; Ependyma; Formaldehyde; Gene | 2007 |
Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition.
Topics: Adjuvants, Immunologic; Animals; Behavior, Animal; Cognition; Drug Interactions; Fear; Formaldehyde; | 2007 |
Prolactin response to formalin is related to the acute nociceptive response and it is attenuated by combined application of different stressors.
Topics: Acute Disease; Animals; Corticosterone; Formaldehyde; Handling, Psychological; Hypoglycemia; Hypogly | 2007 |
The effects of pharmacological blockade of the 5-HT(6) receptor on formalin-evoked nociceptive behaviour, locomotor activity and hypothalamo-pituitary-adrenal axis activity in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Corticosterone; Defecation; Dose-Response Relations | 2007 |
Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Fabaceae; Formaldehy | 2007 |
Analgesia induced by morphine microinjected into the nucleus raphe magnus: effects on tonic pain.
Topics: Analgesia; Analgesics, Opioid; Animals; Disease Models, Animal; Formaldehyde; Male; Microinjections; | 2007 |
Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor.
Topics: Animals; Behavior, Animal; Capsaicin; Cell Count; Enzyme Inhibitors; Excitatory Postsynaptic Potenti | 2007 |
Antinociceptive effect from Davilla elliptica hydroalcoholic extract.
Topics: Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Brazil; Cyclooxygenase Inhibi | 2007 |
Synergistic interaction between meloxicam and aminoguanidine in formalin-induced nociception in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2 Inhibitors; Drug Evaluation, Prec | 2008 |
Pharmacological comparison of anticonvulsant drugs in animal models of persistent pain and anxiety.
Topics: Analgesics; Animals; Anticonvulsants; Anxiety; Chronic Disease; Conditioning, Operant; Electroshock; | 2007 |
Characterization of the antinociceptive and anti-inflammatory activities of doxycycline and minocycline in different experimental models.
Topics: Analgesics; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Carrageenan; Doxycycline; Edem | 2007 |
Involvement of kappa opioid receptors in formalin-induced inhibition of analgesic tolerance to morphine in mice.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 2007 |
Effects of honokiol and magnolol on acute and inflammatory pain models in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biphenyl Compounds; Central Nervous System Depress | 2007 |
Mice overexpressing chemokine ligand 2 (CCL2) in astrocytes display enhanced nociceptive responses.
Topics: Animals; Astrocytes; Chemokine CCL2; Chemokines; Enzyme-Linked Immunosorbent Assay; Formaldehyde; Fr | 2007 |
A novel automated method for measuring the effect of analgesics on formalin-evoked licking behavior in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electronic Data Processing; Formaldehyd | 2008 |
Extended swimming exercise reduces inflammatory and peripheral neuropathic pain in rodents.
Topics: Analysis of Variance; Animals; Cold Temperature; Disease Models, Animal; Formaldehyde; Hyperalgesia; | 2007 |
Influence of nicotinic receptor modulators on CB2 cannabinoid receptor agonist (JWH133)-induced antinociception in mice.
Topics: Animals; Cannabinoids; Dose-Response Relationship, Drug; Formaldehyde; Male; Mecamylamine; Mice; Mot | 2007 |
Dissociation of spinal microglia morphological activation and peripheral inflammation in inflammatory pain models.
Topics: Animals; Behavior, Animal; CD11b Antigen; Cell Count; Cyclooxygenase 1; Cyclooxygenase 2; Disease Mo | 2007 |
Melatonin reduces formalin-induced nociception and tactile allodynia in diabetic rats.
Topics: Analgesics; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Female; Formaldehyde; Guanid | 2007 |
Intrathecal administration of proteinase-activated receptor-2 agonists produces hyperalgesia by exciting the cell bodies of primary sensory neurons.
Topics: Animals; Formaldehyde; Ganglia, Spinal; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; Mem | 2008 |
15d-prostaglandin J2 inhibits inflammatory hypernociception: involvement of peripheral opioid receptor.
Topics: Analgesics; Animals; Carrageenan; Cytokines; Formaldehyde; Hyperalgesia; Inflammation; Macrophages; | 2008 |
Antinociceptive activity of petroleum ether fraction from the MeOH extracts of Paederia scandens in mice.
Topics: Acetic Acid; Alkanes; Analgesics; Animals; Capsaicin; Formaldehyde; Hot Temperature; Methanol; Mice; | 2008 |
Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Acetic Acid; Analgesics; Animals; Benzene Derivatives; Capsa | 2008 |
Role of nitric oxide/cyclic GMP/K(+) channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol.
Topics: Analgesics; Animals; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Formaldehyde; G | 2007 |
The novel compound (+/-)-1-[10-((E)-3-Phenyl-allyl)-3,10-diaza-bicyclo[4.3.1]dec-3-yl]-propan-1-one (NS7051) attenuates nociceptive transmission in animal models of experimental pain; a pharmacological comparison with the combined mu-opioid receptor agoni
Topics: Analgesics, Opioid; Animals; Azabicyclo Compounds; Behavior, Animal; Brain; Dose-Response Relationsh | 2008 |
Alterations in attentional mechanisms in response to acute inflammatory pain and morphine administration.
Topics: Analgesics, Opioid; Animals; Attention; Data Interpretation, Statistical; Formaldehyde; Inflammation | 2008 |
Effect of stimulation and lesion of the thalamic nucleus submedius on formalin-evoked nociceptive behavior in rats.
Topics: Animals; Electric Stimulation; Formaldehyde; Nociception; Pain; Pain Measurement; Rats; Thalamic Nuc | 2007 |
Spinal NTS1 receptors regulate nociceptive signaling in a rat formalin tonic pain model.
Topics: Animals; Disease Models, Animal; Formaldehyde; Male; Neurotensin; Pain; Pain Measurement; Rats; Rats | 2008 |
Role of calcitonin gene-related peptide and substance P in different models of pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Central Nervous System; Formaldehyde; Hyperalgesia; Immuno | 2008 |
Reversal of pathological pain through specific spinal GABAA receptor subtypes.
Topics: Analgesics; Animals; Brain; Capsaicin; Chronic Disease; Diazepam; Disease Models, Animal; Fluorobenz | 2008 |
A nociceptive-intensity-dependent role for hydrogen sulphide in the formalin model of persistent inflammatory pain.
Topics: Alkynes; Animals; Enzyme Inhibitors; Formaldehyde; Glycine; Hydrogen Sulfide; Inflammation; Irritant | 2008 |
Modulation of NMDA receptors by intrathecal administration of the sensory neuron-specific receptor agonist BAM8-22.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Intera | 2008 |
The effects of intrathecal cyclooxygenase-1, cyclooxygenase-2, or nonselective inhibitors on pain behavior and spinal Fos-like immunoreactivity.
Topics: Animals; Behavior, Animal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2008 |
The interaction between inhibitors of nitric oxide synthase and cyclooxygenase in formalin-induced pain in mice: an isobolographic study.
Topics: Animals; Behavior, Animal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxy | 2008 |
Nefopam and ketoprofen synergy in rodent models of antinociception.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, A | 2008 |
Characterization of the hypothalamic proopiomelanocortin gene and beta-endorphin expression in the hypothalamic arcuate nucleus of mice elicited by inflammatory pain.
Topics: Analysis of Variance; Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Calcium-Calmodulin-D | 2008 |
Inorganic arsenic exposure affects pain behavior and inflammatory response in rat.
Topics: Animals; Arsenites; Behavior, Animal; Carrageenan; Dinoprostone; Disease Models, Animal; Drug Admini | 2008 |
The differential effect of morphine and beta-endorphin administered intracerebroventricularly on pERK and pCaMK-II expression induced by various nociceptive stimuli in mice brains.
Topics: Analgesics, Opioid; Animals; beta-Endorphin; Blotting, Western; Brain Chemistry; Calcium-Calmodulin- | 2008 |
[Effects of preemptively injected intrathecal lornoxicam on behavior and c-fos protein expression of rat with formalin hurting].
Topics: Analgesics; Animals; Formaldehyde; Male; Pain; Pain Measurement; Piroxicam; Proto-Oncogene Proteins | 2008 |
Phosphatidylinositol 3-kinase is a key mediator of central sensitization in painful inflammatory conditions.
Topics: Animals; Chromones; Formaldehyde; Inflammation; Inflammation Mediators; Male; Morpholines; Pain; Pai | 2008 |
The influence of sex and ovarian hormones on temporomandibular joint nociception in rats.
Topics: Animals; Behavior, Animal; Diestrus; Estradiol; Female; Formaldehyde; Glutamic Acid; Humans; Injecti | 2008 |
The effect of formalin pretreatment on nicotine-induced antinociceptive effect: the role of mu-opioid receptor in the hippocampus.
Topics: Acetic Acid; Analgesics; Animals; Benzoxazines; Blotting, Western; Brain; Coloring Agents; Drug Tole | 2008 |
Dopamine D2-like receptor in the nucleus accumbens is involved in the antinociceptive effect of nitrous oxide.
Topics: Analgesics; Animals; Behavior, Animal; Disease Models, Animal; Dopamine Antagonists; Formaldehyde; M | 2008 |
Anti-inflammatory and antinociceptive activity of Thymus pubescens extract.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationshi | 2008 |
Objective evaluation of analgesic effect of drugs in laboratory animals by a new methodological approach.
Topics: Analgesia; Analgesics; Animals; Behavior, Animal; Bradykinin; Disease Models, Animal; Dogs; Drug Eva | 1982 |
Tonic analgesic effects of delta 9-tetrahydrocannabinol as measured with the formalin test.
Topics: Analgesics; Animals; Body Temperature; Dronabinol; Female; Formaldehyde; Male; Pain; Rats; Time Fact | 1980 |
Effects of peripheral antisympathetic treatments in the tail-flick, formalin and autotomy tests.
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Formaldehyde; Guanethidine; Hot Tempe | 1984 |
The formalin test: a tonic pain model in the primate.
Topics: Animals; Behavior, Animal; Chronic Disease; Disease Models, Animal; Female; Formaldehyde; Hand; Maca | 1984 |
[Formalin-induced minor tremor response as an indicator of pain].
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Carrageenan; Disease Models, Animal; Dose-Response Relati | 1984 |
Single nerve capsaicin: effects on pain and morphine analgesia in the formalin and foot-flick tests.
Topics: Analgesia; Animals; Capsaicin; Formaldehyde; Male; Morphine; Pain; Peripheral Nerves; Rats; Sciatic | 1984 |
Effects of cholinergic and dopaminergic agents on pain and morphine analgesia measured by three pain tests.
Topics: Animals; Drug Synergism; Formaldehyde; Male; Morphine; Pain; Parasympathomimetics; Rats; Rats, Inbre | 1983 |
Effects of single doses of capsaicin on nociceptive thresholds in the rodent.
Topics: Acetylcholine; Animals; Capsaicin; Fatty Acids, Unsaturated; Formaldehyde; Hot Temperature; Male; Mi | 1981 |
Apparent lack of tolerance in the formalin test suggests different mechanisms for morphine analgesia in different types of pain.
Topics: Animals; Behavior, Animal; Drug Tolerance; Formaldehyde; Grooming; Morphine; Pain; Rats | 1981 |
Persistent cardiovascular and behavioral nociceptive responses to subcutaneous formalin require peripheral nerve input.
Topics: Anesthesia; Anesthetics, Local; Animals; Behavior, Animal; Blood Pressure; Dose-Response Relationshi | 1995 |
Dextromethorphan suppresses both formalin-induced nociceptive behavior and the formalin-induced increase in spinal cord c-fos mRNA.
Topics: Animals; Behavior, Animal; Depression, Chemical; Dextromethorphan; Formaldehyde; Male; Mice; Mice, I | 1995 |
Changes of spinal substance P, calcitonin gene-related peptide, somatostatin, Met-enkephalin and neurotensin in rats in response to formalin-induced pain.
Topics: Animals; Calcitonin Gene-Related Peptide; Enkephalin, Methionine; Female; Formaldehyde; Image Proces | 1994 |
Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation.
Topics: Administration, Topical; Amino Acid Oxidoreductases; Animals; Arginine; Behavior, Animal; Dose-Respo | 1994 |
Inflammation of the colonic wall induced by formalin as a model of acute visceral pain.
Topics: Acute Disease; Animals; Colitis; Disease Models, Animal; Female; Formaldehyde; Morphine; Naloxone; P | 1994 |
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; F | 1994 |
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Topics: Animals; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Male; Morphine; Naltrexone; Neur | 1995 |
Scratching behavior induced by pruritogenic but not algesiogenic agents in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Formaldehyde; Histamine; Male; Mice; p-Methoxy-N-methylpheneth | 1995 |
The neurokinin-1 receptor antagonist, sendide, exhibits antinociceptive activity in the formalin test.
Topics: Animals; Behavior, Animal; Formaldehyde; Injections, Spinal; Male; Mice; Mice, Inbred Strains; Neuro | 1995 |
Analgesia induced by morphine microinjection into the lateral hypothalamus of the rat.
Topics: Analgesia; Animals; Electric Stimulation; Formaldehyde; Hypothalamus; Male; Microinjections; Morphin | 1995 |
Hypophysectomy produces analgesia and paraventricular lesions have no effect on formalin-induced pain.
Topics: Analgesia; Animals; Formaldehyde; Hypophysectomy; Male; Pain; Pain Measurement; Palliative Care; Par | 1995 |
Role of GABAergic systems in the development of morphine tolerance in formalin-treated mice.
Topics: Analgesics, Opioid; Animals; Baclofen; Bicuculline; Diazepam; Drug Tolerance; Flumazenil; Formaldehy | 1995 |
Antinociceptive activity of filenadol on inflammatory pain.
Topics: Analgesics; Animals; Benzoquinones; Codeine; Formaldehyde; Hyperalgesia; Indomethacin; Inflammation; | 1995 |
Effects of formalin-induced pain on ACTH, beta-endorphin, corticosterone and interleukin-6 plasma levels in rats.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; beta-Endorphin; Corticosterone; Formaldehyde | 1995 |
The induction of Fos-like immunoreactivity by noxious thermal, mechanical and chemical stimuli in the lumbar spinal cord of infant rats.
Topics: Animals; Animals, Newborn; Formaldehyde; Histocytochemistry; Hot Temperature; Lumbosacral Region; Pa | 1995 |
Peripheral opioid modulation of pain and inflammation in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1995 |
Caffeine antinociception in the rat hot-plate and formalin tests and locomotor stimulation: involvement of noradrenergic mechanisms.
Topics: Adrenergic alpha-Antagonists; Animals; Caffeine; Dioxanes; Drug Synergism; Formaldehyde; Hot Tempera | 1995 |
Antinociceptive profiles of non-peptidergic neurokinin1 and neurokinin2 receptor antagonists: a comparison to other classes of antinociceptive agent.
Topics: Amino Acid Sequence; Analgesics; Analysis of Variance; Animals; Formaldehyde; Male; Mice; Mice, Inbr | 1995 |
CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Formaldehyde; Heart Rate; Hot Temperature; Injections, | 1993 |
L-NG-nitro arginine p-nitroanilide (L-NAPNA) is anti-nociceptive in the mouse.
Topics: Amino Acid Oxidoreductases; Analgesics; Anilides; Animals; Aorta, Thoracic; Arginine; Blood Pressure | 1993 |
Antinociception induced by CP 96,345, a non-peptide NK-1 receptor antagonist, in the mouse formalin and capsaicin tests.
Topics: Analgesics; Animals; Biphenyl Compounds; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; | 1993 |
Effects of mexiletine on formalin-induced nociceptive responses in mice.
Topics: Animals; Diabetes Mellitus, Experimental; Formaldehyde; Injections, Intraperitoneal; Injections, Spi | 1993 |
Further evidence that substance P is a mediator of both neurogenic inflammation and pain: two phenomena inhibited either by postsynaptic blockade of NK1 receptors or by presynaptic action of opioid receptor agonists.
Topics: Analgesics; Animals; Anticonvulsants; Electric Stimulation; Formaldehyde; Indoles; Inflammation; Iso | 1993 |
Nitric oxide synthase inhibitor blocks spinal sensitization induced by formalin injection into the rat paw.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Dose-Response Relationship, Drug; Formaldehyde; Infla | 1993 |
Antinociceptive effects in the formalin and capsaicin tests after intrathecal administration of substance P analogues in mice.
Topics: Analgesics; Animals; Capsaicin; Drug Interactions; Formaldehyde; Injections, Spinal; Male; Mice; Nal | 1993 |
The analgesia induced by intrathecal injection of ruthenium red.
Topics: Analgesics; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Injections, Spinal; Male; Mice; Mice | 1993 |
The formalin test: scoring properties of the first and second phases of the pain response in rats.
Topics: Amphetamine; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Morphi | 1995 |
Cyclooxygenase inhibition and the spinal release of prostaglandin E2 and amino acids evoked by paw formalin injection: a microdialysis study in unanesthetized rats.
Topics: Amino Acids; Analysis of Variance; Animals; Aspartic Acid; Dinoprostone; Formaldehyde; Glutamic Acid | 1995 |
Effects of partial decortication on opioid analgesia in the formalin test.
Topics: Amygdala; Analgesia; Animals; Behavior, Animal; Brain Injuries; Formaldehyde; Morphine; Motor Activi | 1995 |
Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C.
Topics: Alkaloids; Analysis of Variance; Animals; Benzophenanthridines; Formaldehyde; Functional Laterality; | 1995 |
Antinociceptive effect of morphine microinjections into the spinal trigeminal subnucleus oralis.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Microinjections; Morphine; Naloxone; | 1995 |
Effects of subcutaneous formalin on the activity of trigeminal brain stem nociceptive neurones in the rat.
Topics: Animals; Brain Stem; Formaldehyde; Injections, Subcutaneous; Male; Neural Inhibition; Neurons; Nocic | 1995 |
Chemically-diverse ligands at the glycine B site coupled to N-methyl-D-aspartate (NMDA) receptors selectively block the late phase of formalin-induced pain in mice.
Topics: 2-Amino-5-phosphonovalerate; Acetates; Acetic Acid; Animals; Anticonvulsants; Cycloserine; Dizocilpi | 1994 |
'Mirror pain' and indications of bilateral dorsal horn activation in response to unilateral nociception.
Topics: Animals; Cats; Deoxyglucose; Formaldehyde; Pain; Pain Measurement; Rats; Spinal Cord | 1994 |
Inhibition of nociception-induced spinal sensitization by anesthetic agents.
Topics: Analgesia; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Drug Interactions; Formaldehy | 1995 |
Analgesic effects of callus culture extracts from selected species of Phyllanthus in mice.
Topics: Abdominal Muscles; Acetates; Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Fem | 1994 |
Tolrestat treatment prevents modification of the formalin test model of prolonged pain in hyperglycemic rats.
Topics: Aldehyde Reductase; Animals; Behavior, Animal; Body Weight; Diabetes Mellitus, Experimental; Female; | 1994 |
Sex differences in the behavioural response to persistent pain in rats.
Topics: Animals; Behavior, Animal; Female; Formaldehyde; Male; Pain; Pain Measurement; Rats; Rats, Wistar; S | 1994 |
Changes in hypothalamic met-enkephalin levels of rats induced by painful stimulation and morphine treatment.
Topics: Animals; Enkephalin, Methionine; Formaldehyde; Hypothalamus; Male; Morphine; Naloxone; Pain; Rats; R | 1993 |
Morphine dependence with or without tolerance in formalin-treated mice: further evidence for the dissociation.
Topics: Analgesia; Animals; Anxiety; Disease Models, Animal; Drug Tolerance; Formaldehyde; Injections, Intra | 1994 |
Antinociceptive effect of intrathecally administered P2-purinoceptor antagonists in rats.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Formaldehyde; Injections, Spinal; Male; Nocicepto | 1994 |
Dissociation of the alpha 2-adrenergic antinociception from sedation following microinjection of medetomidine into the locus coeruleus in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Decerebrate State; Formaldehyde; Hypnotics and Sedatives; Imi | 1994 |
Analysis of the role of endothelin-A and endothelin-B receptors on nociceptive information transmission in the spinal cord with FR139317, an endothelin-A receptor antagonist, and sarafotoxin S6c, an endothelin-B receptor agonist.
Topics: Animals; Arginine; Azepines; Behavior, Animal; Endothelin Receptor Antagonists; Endothelins; Formald | 1994 |
Involvement of pain associated anxiety in the development of morphine tolerance in formalin treated mice.
Topics: Animals; Anxiety; Aspirin; Diazepam; Drug Tolerance; Flumazenil; Formaldehyde; Indomethacin; Inflamm | 1994 |
Differential effects of morphine on noxious stimulus-evoked fos-like immunoreactivity in subpopulations of spinoparabrachial neurons.
Topics: Animals; Behavior, Animal; Fluorescent Dyes; Formaldehyde; Immunohistochemistry; Male; Mesencephalon | 1994 |
Systemic opioids do not suppress spinal sensitization after subcutaneous formalin in rats.
Topics: Alfentanil; Animals; Drug Administration Schedule; Formaldehyde; Hot Temperature; Hyperalgesia; Inje | 1994 |
Pentobarbitone, but not propofol, produces pre-emptive analgesia in the rat formalin model.
Topics: Analgesics; Anesthesia, Intravenous; Animals; Behavior, Animal; Disease Models, Animal; Formaldehyde | 1994 |
Antinociception induced by 3-((+-)-2-carboxypiperazin-4-yl)-propyl-1- phosphonic acid (CPP), an N-methyl-D-aspartate (NMDA) competitive antagonist, plus 6,7-dinitroquinoxaline-2,3-dione (DNQX), a non-NMDA antagonist, differs from that induced by MK-801 pl
Topics: Animals; Dizocilpine Maleate; Formaldehyde; Injections, Spinal; Male; Mice; Pain; Pain Measurement; | 1994 |
Antinociceptive effects of intrathecal administration of alpha-adrenoceptor antagonists and clonidine in the formalin test in the mouse.
Topics: Adrenergic alpha-Antagonists; Analgesics; Animals; Body Temperature; Clonidine; Formaldehyde; Inject | 1993 |
Taurine modulates chemical nociception in mice.
Topics: Acetates; Animals; Formaldehyde; Male; Mice; Naloxone; Nociceptors; Pain; Pain Measurement; Reaction | 1993 |
Effects of descending inhibitory systems on the c-Fos expression in the rat spinal cord during formalin-induced noxious stimulation.
Topics: Afferent Pathways; Animals; Female; Formaldehyde; Gene Expression; Genes, fos; Immunohistochemistry; | 1994 |
Morphine, clonidine coadministration in subanalgesic doses: effective control of tonic pain.
Topics: Animals; Clonidine; Dose-Response Relationship, Drug; Drug Synergism; Female; Formaldehyde; Injectio | 1994 |
Expression of Krev-1 and c-H-ras proto-oncogenes in the rat spinal cord and the effects of noxious stimulation.
Topics: Aging; Animals; Animals, Newborn; Blotting, Northern; Brain; Formaldehyde; Genes, ras; GTP-Binding P | 1993 |
The effect of intrathecal administration of RP67580, a potent neurokinin 1 antagonist on nociceptive transmission in the rat spinal cord.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Ma | 1993 |
Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats.
Topics: Analgesics; Animals; Arginine; Behavior, Animal; Formaldehyde; Hot Temperature; Injections, Spinal; | 1993 |
Anti-nociceptive effects of the GM1 ganglioside derivative AGF 44 on the formalin test in normal and streptozotocin-diabetic rats.
Topics: Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Escape Reaction; Female; Formaldehyde; G | 1993 |
Effects of intrathecal FK888, a novel dipeptide NK1 receptor antagonist, on the formalin test in the rat.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Dipeptides; Escape Reaction; Formaldehyde; Indoles; I | 1993 |
Development of tolerance to morphine antinociception in mice treated with nociceptive stimulants.
Topics: Acetates; Acetic Acid; Animals; Drug Tolerance; Formaldehyde; Freund's Adjuvant; Hindlimb; Male; Mic | 1993 |
Formalin-induced pain antagonizes the development of opiate dependence in the rat.
Topics: Animals; Behavior, Animal; Blepharoptosis; Diarrhea; Formaldehyde; Male; Morphine Dependence; Naloxo | 1993 |
GABA B mediated analgesia in tonic pain in monkeys.
Topics: Analgesics; Animals; Baclofen; Dose-Response Relationship, Drug; Formaldehyde; Macaca mulatta; Male; | 1993 |
Decrease of hippocampal choline acetyltransferase activity induced by formalin pain.
Topics: Analysis of Variance; Animals; Choline O-Acetyltransferase; Formaldehyde; Functional Laterality; Hip | 1993 |
Morphine fails to produce tolerance when administered in the presence of formalin pain in rats.
Topics: Animals; Drug Tolerance; Formaldehyde; Male; Morphine; Pain; Pain Measurement; Rats; Rats, Sprague-D | 1993 |
NK-1 and NK-3 type tachykinin receptor mRNA expression in the rat spinal cord dorsal horn is increased during adjuvant or formalin-induced nociception.
Topics: Animals; Base Sequence; DNA Primers; Exons; Formaldehyde; Freund's Adjuvant; Ganglia, Spinal; Gene E | 1994 |
Streptozocin-induced diabetic rats: behavioural evidence for a model of chronic pain.
Topics: Animals; Behavior, Animal; Blood Glucose; Chronic Disease; Diabetes Mellitus, Experimental; Disease | 1993 |
Naloxone causes apparent antinociception and pronociception simultaneously in the rat paw formalin test.
Topics: Animals; Behavior, Animal; Buprenorphine; Dose-Response Relationship, Drug; Formaldehyde; Injections | 1993 |
More about the formalin test.
Topics: Animals; Formaldehyde; Pain; Rats | 1993 |
Effects of formalin-induced pain on exploratory behaviour in rabbits.
Topics: Animals; Corticosterone; Exploratory Behavior; Formaldehyde; Male; Pain; Rabbits; Testosterone | 1993 |
NMDA receptor antagonists, MK-801 and ACEA-1011, prevent the development of tonic pain following subcutaneous formalin.
Topics: Analgesics; Animals; Behavior, Animal; Dizocilpine Maleate; Foot; Formaldehyde; Injections, Subcutan | 1993 |
(+)-HA 966, a partial agonist at the glycine site coupled to NMDA receptors, blocks formalin-induced pain in mice.
Topics: Animals; Formaldehyde; Glycine; Hindlimb; Male; Mice; Pain; Pyrrolidinones; Receptors, N-Methyl-D-As | 1993 |
The formalin test in the naked mole-rat (Heterocephalus glaber): analgesic effects of morphine, nefopam and paracetamol.
Topics: Acetaminophen; Analgesics; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Formalde | 1993 |
The role of previous nociceptive input in development of autotomy following cordotomy.
Topics: Animals; Arthritis, Experimental; Burns; Denervation; Formaldehyde; Nociceptors; Pain; Rats; Rats, S | 1993 |
Effects of codeine, naproxen and dexamethasone on formalin-induced pain in the naked mole-rat.
Topics: Animals; Behavior, Animal; Codeine; Dexamethasone; Dose-Response Relationship, Drug; Formaldehyde; I | 1993 |
Habenula lesions attenuate lateral hypothalamic analgesia in the formalin test.
Topics: Analgesia; Animals; Caudate Nucleus; Electric Stimulation; Female; Formaldehyde; Hypothalamic Area, | 1993 |
Amygdalar involvement in pain.
Topics: Amygdala; Animals; Electric Stimulation; Emotions; Formaldehyde; Male; Pain; Pain Measurement; Pain | 1995 |
Opioid antagonists and antisera to endogenous opioids increase the nociceptive response to formalin: demonstration of an opioid kappa and delta inhibitory tone.
Topics: Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Formaldehyde; Immune Sera; Male; Naloxone | 1996 |
The development of opioid tolerance in the formalin test in the rat.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Implants; Drug Tolerance; Formaldehyde; Hindlimb | 1995 |
Delayed nociceptive response following cold-water swim in the formalin test: possible mechanisms of action.
Topics: Animals; Cold Temperature; Dizocilpine Maleate; Formaldehyde; Male; Neuronal Plasticity; Nociceptors | 1996 |
Restraint reduces formalin-test pain but the effect is not influenced by lesions of the hypothalamic paraventricular nucleus.
Topics: Analgesia; Animals; Behavior, Animal; Formaldehyde; Male; Pain; Paraventricular Hypothalamic Nucleus | 1996 |
Effects of morphine, pentobarbital and amphetamine on formalin-induced behaviours in infant rats: sedation versus specific suppression of pain.
Topics: Amphetamine; Animals; Animals, Newborn; Behavior, Animal; Female; Formaldehyde; Hypnotics and Sedati | 1995 |
Nitrous oxide or halothane, or both, fail to suppress c-fos expression in rat spinal cord dorsal horn neurones after subcutaneous formalin.
Topics: Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Behavior, Animal; Cell Count; Fentanyl; | 1996 |
Stimulation of glucose utilization in the rat claustrum by pain.
Topics: Animals; Basal Ganglia; Deoxyglucose; Formaldehyde; Glucose; Injections, Subcutaneous; Pain; Rats; R | 1995 |
Time-related roles of excitatory amino acid receptors during persistent noxiously evoked responses of rat dorsal horn neurones.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Excitatory Amino Acid Antagonists; | 1995 |
Subnuclear localization of FOS-like immunoreactivity in the rat parabrachial nucleus after nociceptive stimulation.
Topics: Animals; Brachial Plexus; Formaldehyde; Immunohistochemistry; Male; Neurons; Nociceptors; Pain; Phys | 1996 |
The effect of pituitary adenylate cyclase activating peptide (PACAP) on the nociceptive formalin test.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Neuropeptides; Neurotransmitter Agent | 1996 |
Effect of picrotoxin on antinociception in the formalin test.
Topics: Animals; Formaldehyde; GABA Antagonists; Male; Mice; Pain; Pain Measurement; Pain Threshold; Picroto | 1996 |
Effects of local anaesthesia on formalin-induced Fos expression in the rat dorsal horn.
Topics: Anesthesia, Local; Anesthetics, Local; Animals; Felypressin; Formaldehyde; Ganglia, Spinal; Hemostat | 1995 |
Contribution of peripheral alpha 1A-adrenoceptors to pain induced by formalin or by alpha-methyl-5-hydroxytryptamine plus noradrenaline.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Agon | 1996 |
Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw.
Topics: Animals; Enzyme Induction; Foot; Formaldehyde; Injections; Male; NG-Nitroarginine Methyl Ester; Nitr | 1996 |
The effect of lesions of the dorsolateral funiculus on formalin pain and morphine analgesia: a dose-response analysis.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Hot T | 1996 |
Dual effect of serotonin on formalin-induced nociception in the rat spinal cord.
Topics: 5,7-Dihydroxytryptamine; Animals; Dose-Response Relationship, Drug; Formaldehyde; Granisetron; Injec | 1996 |
Expression of B1 kinin receptors mediating paw edema and formalin-induced nociception. Modulation by glucocorticoids.
Topics: Animals; Bradykinin Receptor Antagonists; Dexamethasone; Dose-Response Relationship, Drug; Edema; Fo | 1995 |
Central noradrenergic and cholinergic modulation of formaldehyde-induced pedal inflammation and nociception in rats.
Topics: Acetylcholine; Adrenergic Agents; Animals; Cholinergic Agents; Foot; Formaldehyde; Inflammation; Inj | 1996 |
Medial frontal cortex lesions selectively attenuate the hot plate response: possible nocifensive apraxia in the rat.
Topics: Animals; Apraxias; Defense Mechanisms; Formaldehyde; Frontal Lobe; Hot Temperature; Male; Pain; Pain | 1996 |
The formalin test in rat: validation of an automated system.
Topics: Animals; Behavior, Animal; Biphenyl Compounds; Dose-Response Relationship, Drug; Evaluation Studies | 1996 |
A new nitric oxide donor, NOC-18, exhibits a nociceptive effect in the rat formalin model.
Topics: Animals; Antidotes; Behavior, Animal; Formaldehyde; Injections, Intraventricular; Injections, Subcut | 1996 |
The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Biphenyl Compounds; Carrageenan; | 1996 |
Formalin- and carrageenan-induced inflammation attenuates place preferences produced by morphine, methamphetamine and cocaine.
Topics: Animals; Behavior, Animal; Carrageenan; Cocaine; Conditioning, Operant; Formaldehyde; Indomethacin; | 1996 |
Effects of morphine microinjections into the trigeminal sensory complex on the formalin test in the rat.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Formaldehyde; Lip; Male; Microinjections; Morphine; N | 1996 |
Selective N-type neuronal voltage-sensitive calcium channel blocker, SNX-111, produces spinal antinociception in rat models of acute, persistent and neuropathic pain.
Topics: Analgesics; Animals; Calcium Channel Blockers; Disease Models, Animal; Formaldehyde; Ion Channel Gat | 1996 |
Is pentobarbital analgesic in the rat formalin test?
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Hypnotics and Sedatives; Pain; Pentobarbita | 1997 |
LY303870, a centrally active neurokinin-1 antagonist with a long duration of action.
Topics: Animals; Drug Synergism; Electroshock; Formaldehyde; Guinea Pigs; Humans; Indoles; Injections, Spina | 1997 |
Efficacy of spinal NMDA receptor antagonism in formalin hyperalgesia and nerve injury evoked allodynia in the rat.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dextromethorphan; Dextrorphan; Dizocilpine Maleate | 1997 |
Early nociceptive events influence the temporal profile, but not the magnitude, of the tonic response to subcutaneous formalin: effects with remifentanil.
Topics: Analgesics, Opioid; Analysis of Variance; Anesthesia, Inhalation; Animals; Blood Pressure; Formaldeh | 1997 |
Naloxone-reversible antinociception by paracetamol in the rat.
Topics: Acetaminophen; Animals; Cerebral Cortex; Formaldehyde; Hot Temperature; Ketanserin; Kinetics; Male; | 1997 |
Influence of low and high doses of naloxone on tonic pain and motor activity in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Motor Activity; Nal | 1996 |
Medullary catecholaminergic neurons projecting to lateral hypothalamic area and expressing Fos after chemical stimulation of the stomach in the rat.
Topics: Animals; Axonal Transport; Brain Mapping; Formaldehyde; Horseradish Peroxidase; Hypothalamic Area, L | 1997 |
Differential contribution of the two phases of the formalin test to the pattern of c-fos expression in the rat spinal cord: studies with remifentanil and lidocaine.
Topics: Analgesics, Opioid; Anesthetics, Local; Animals; Bupivacaine; Formaldehyde; Immunohistochemistry; Li | 1997 |
The effects of mexiletine, desipramine and fluoxetine in rat models involving central sensitization.
Topics: Animals; Anti-Arrhythmia Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tr | 1997 |
Continuous intravenous infusion of naloxone does not change behavioral, cardiovascular, or inflammatory responses to subcutaneous formalin in the rat.
Topics: Animals; Behavior, Animal; Blood Pressure; Formaldehyde; Heart Rate; Hemodynamics; Inflammation; Inf | 1997 |
Central serotonergic and histaminergic modulation of peripheral inflammation and nociception in rats.
Topics: Animals; Foot; Formaldehyde; Histamine; Histamine Agonists; Histamine Antagonists; Inflammation; Inj | 1996 |
Comparison of the effects of nucleus tractus solitarius and ventral medial medulla lesions on illness-induced and subcutaneous formalin-induced hyperalgesias.
Topics: Animals; Formaldehyde; Hyperalgesia; Injections, Intraperitoneal; Injections, Subcutaneous; Lipopoly | 1997 |
Dorsal hippocampus field CA1 pyramidal cell responses to a persistent versus an acute nociceptive stimulus and their septal modulation.
Topics: Animals; Brain Mapping; Electroencephalography; Formaldehyde; Functional Laterality; Hindlimb; Hippo | 1997 |
Inhalation anesthetics suppress the expression of c-Fos protein evoked by noxious somatic stimulation in the deeper layer of the spinal cord in the rat.
Topics: Analgesia; Anesthetics, Inhalation; Animals; Formaldehyde; Halothane; Hindlimb; Male; Naloxone; Narc | 1997 |
Noxious stimulation enhances release of cytokine-induced neutrophil chemoattractant from hypothalamic neurosecretory cells.
Topics: Animals; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Colchicine; Formaldehyde; Growth Sub | 1997 |
Optimal scoring strategies and weights for the formalin test in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bradykinin; Dose-Response Relationship, Drug; Formald | 1997 |
The contribution of metabotropic glutamate receptors (mGluRs) to formalin-induced nociception.
Topics: Aminobutyrates; Analysis of Variance; Animals; Benzoates; Cycloleucine; Cyclopropanes; Excitatory Am | 1996 |
Peripheral NMDA and non-NMDA glutamate receptors contribute to nociceptive behaviors in the rat formalin test.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Axons; Dizocilpine Maleate; Excitatory Amino Acid Ant | 1997 |
Signal changes in the spinal cord of the rat after injection of formalin into the hindpaw: characterization using functional magnetic resonance imaging.
Topics: Animals; Formaldehyde; Hindlimb; Magnetic Resonance Imaging; Male; Pain; Rats; Rats, Sprague-Dawley; | 1997 |
Coincident induction of K rev-1/rap 1A, rap 1B and H-ras mRNAs in the rat spinal cord by noxious stimulation.
Topics: Amino Acid Sequence; Animals; Base Sequence; DNA Primers; DNA, Complementary; Formaldehyde; Genes, r | 1997 |
Attenuation of formalin pain responses in the rat by adrenal medullary transplants in the spinal subarachnoid space.
Topics: Adrenal Medulla; Adrenergic alpha-Antagonists; Animals; Foot; Formaldehyde; Injections; Male; Naloxo | 1997 |
Repeated cold water swim produces delayed nociceptive responses, but not analgesia, for tonic pain in the rat.
Topics: Analgesia; Animals; Body Temperature; Cold Temperature; Formaldehyde; Hypothalamo-Hypophyseal System | 1997 |
[Changes in opioid receptor binding nature in rat brain and spinal cord following formalin or carrageenan-induced nociception].
Topics: Animals; Brain; Carrageenan; Formaldehyde; Male; Pain; Rats; Rats, Sprague-Dawley; Receptors, Opioid | 1997 |
Effects of the bradykinin B1 receptor antagonist des-Arg9[Leu8]bradykinin and genetic disruption of the B2 receptor on nociception in rats and mice.
Topics: Animals; Bradykinin; Bradykinin Receptor Antagonists; Carrageenan; Edema; Female; Formaldehyde; Freu | 1997 |
Association of serotonin-like immunoreactive axons with nociceptive projection neurons in the caudal spinal trigeminal nucleus of the rat.
Topics: Animals; Antibody Specificity; Axons; Coloring Agents; Fluorescent Antibody Technique; Formaldehyde; | 1997 |
Neonatal capsaicin treatment abolishes formalin-induced spinal PGE2 release.
Topics: Amino Acids; Animals; Animals, Newborn; Capsaicin; Dinoprostone; Formaldehyde; Pain; Rats; Rats, Spr | 1997 |
Role of spinal gamma-aminobutyric acidA receptors in formalin-induced nociception in the rat.
Topics: Animals; Bicuculline; Formaldehyde; GABA-A Receptor Agonists; GABA-A Receptor Antagonists; Injection | 1997 |
Inhibition of nitric oxide synthase enhances antinociception mediated by mu, delta and kappa opioid receptors in acute and prolonged pain in the rat spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; E | 1997 |
Formalin-induced nociceptive behavior and edema: involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes.
Topics: Animals; Edema; Formaldehyde; Indoles; Inflammation; Ketanserin; Male; Pain; Propranolol; Rats; Rats | 1997 |
Analgesic effect of intrathecally administered nociceptin, an opioid receptor-like1 receptor agonist, in the rat formalin test.
Topics: Analgesia; Animals; Behavior, Animal; Formaldehyde; Hot Temperature; Injections, Spinal; Male; Nocic | 1997 |
Further evidence for the involvement of tachykinin receptor subtypes in formalin and capsaicin models of pain in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Disease Models, Animal; Drug Interactions; Formaldehyde; Injec | 1997 |
The role of corticosterone in the blockade of tolerance to morphine analgesia by formalin-induced pain in the rat.
Topics: Animals; Corticosterone; Drug Tolerance; Formaldehyde; Male; Metyrapone; Morphine; Narcotics; Pain; | 1997 |
Sex-dependent effects of formalin and restraint on c-Fos expression in the septum and hippocampus of the rat.
Topics: Animals; Brain Chemistry; Female; Formaldehyde; Hippocampus; Immunohistochemistry; Male; Pain; Pain | 1997 |
Microinjections of muscimol into lateral superior colliculus disrupt orienting and oral movements in the formalin model of pain.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Functional Latera | 1997 |
Formalin-evoked Fos expression in spinal cord is enhanced in morphine-tolerant rats.
Topics: Animals; Drug Tolerance; Formaldehyde; Hindlimb; Hyperalgesia; Male; Morphine; Narcotics; Pain; Plac | 1997 |
[Increase of mu opioid receptor density in rat central nervous system following formalin nociception and its enhancement by electroacupuncture].
Topics: Acupuncture Analgesia; Animals; Autoradiography; Brain; Electroacupuncture; Formaldehyde; Male; Noci | 1996 |
Orphanin FQ potentiates formalin-induced pain behavior and antagonizes morphine analgesia in rats.
Topics: Analgesia; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Morphine | 1997 |
Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intrader | 1997 |
A role of periaqueductal grey NMDA receptors in mediating formalin-induced pain in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Formaldehyde; Hot Temperature; Injections; Male; Pain; Periaqu | 1997 |
Differential expression of the AP-1/CRE-binding proteins FOS and CREB in preproenkephalin mRNA-expressing neurons of the rat parabrachial nucleus after nociceptive stimulation.
Topics: Animals; Brain Stem; Cyclic AMP Response Element-Binding Protein; Enkephalins; Formaldehyde; Gene Ex | 1997 |
Comparison of the effects of treatment with intrathecal lidocaine given before and after formalin on both nociception and Fos expression in the spinal cord dorsal horn.
Topics: Anesthetics, Local; Animals; Formaldehyde; Lidocaine; Male; Pain; Proto-Oncogene Proteins c-fos; Rat | 1998 |
Spinal neurokinin NK1 receptor down-regulation and antinociception: effects of spinal NK1 receptor antisense oligonucleotides and NK1 receptor occupancy.
Topics: Animals; Down-Regulation; Formaldehyde; Indoles; Injections, Spinal; Isoindoles; Male; N-Methylaspar | 1998 |
The interaction of FK409, a novel nitric oxide releaser, and peripherally administered morphine during experimental inflammation.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Formaldehyde; Inflamma | 1998 |
Persisting sensitization of the behavioural response to formalin-induced injury in the rat through activation of serotonin2A receptors.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Dinoprostone; Foot; Formaldehyde | 1997 |
The effect of a selective alpha2-adrenoceptor antagonist on pain behavior of the rat varies, depending on experimental parameters.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Anta | 1998 |
Hypoalgesia in mice with a targeted deletion of the tachykinin 1 gene.
Topics: Acetic Acid; Alleles; Animals; Biomarkers; Calcitonin Gene-Related Peptide; Formaldehyde; Ganglia, S | 1998 |
[Preemptive analgesia].
Topics: Animals; Bicuculline; Dose-Response Relationship, Drug; Formaldehyde; GABA Antagonists; gamma-Aminob | 1997 |
Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors.
Topics: Animals; Dextrorphan; Foot; Formaldehyde; Injections, Intradermal; Ketamine; Male; Memantine; Motor | 1998 |
Is there a correlation between scores of nociceptive behavioral responses to formalin injections given at different body sites in the rat?
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Extremities; Formaldehyde; Injections, Subcu | 1998 |
Altered nociception, analgesia and aggression in mice lacking the receptor for substance P.
Topics: Aggression; Analgesia; Analgesics, Opioid; Animals; Electric Stimulation; Electromyography; Female; | 1998 |
Differential activation of spinal dorsal horn units by subcutaneous formalin injection in the cat: an electrophysiological study.
Topics: Animals; Cats; Evoked Potentials; Female; Formaldehyde; Injections, Subcutaneous; Male; Neurons; Pai | 1998 |
Pituitary-adrenocortical responses to persistent noxious stimuli in the awake rat: endogenous corticosterone does not reduce nociception in the formalin test.
Topics: Adrenal Cortex; Adrenalectomy; Adrenocorticotropic Hormone; Animals; Behavior, Animal; Blood Pressur | 1998 |
Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action.
Topics: Analgesics, Non-Narcotic; Animals; Capsaicin; Dipyrone; Enzyme Inhibitors; Formaldehyde; Glutamic Ac | 1998 |
Ginsenoside Rf, a trace component of ginseng root, produces antinociception in mice.
Topics: Abdominal Muscles; Analgesics; Animals; Behavior, Animal; Body Temperature; Calcium Channel Blockers | 1998 |
Ginsenosides induce differential antinociception and inhibit substance P induced-nociceptive response in mice.
Topics: Analgesia; Animals; Central Nervous System Agents; Female; Formaldehyde; Ginsenosides; Mice; Nocicep | 1998 |
Nociceptive stimulus induces release of endogenous beta-endorphin in the rat brain.
Topics: Animals; Arcuate Nucleus of Hypothalamus; beta-Endorphin; Formaldehyde; Male; Microdialysis; Nocicep | 1998 |
Sevoflurane suppresses behavioral response in the rat formalin test: combination with intrathecal lidocaine produced profound suppression of the response.
Topics: Anesthetics, Inhalation; Anesthetics, Local; Animals; Behavior, Animal; Drug Synergism; Formaldehyde | 1998 |
Differential effect of selective cyclooxygenase-2 (COX-2) inhibitor NS 398 and diclofenac on formalin-induced nociception in the rat.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dose- | 1998 |
Spinal serotonergic receptors mediate facilitation of a nociceptive reflex by subcutaneous formalin injection into the hindpaw in rats.
Topics: Animals; Formaldehyde; Hindlimb; Hot Temperature; Hyperalgesia; Injections, Subcutaneous; Male; Noci | 1998 |
The effects of prior chronic stress on cardiovascular responses to acute restraint and formalin injection.
Topics: Adrenocorticotropic Hormone; Animals; Behavior, Animal; Blood Pressure; Cardiovascular Physiological | 1998 |
Control of pain initiation by endogenous cannabinoids.
Topics: Amides; Analgesics; Animals; Arachidonic Acids; Cannabinoids; Drug Synergism; Endocannabinoids; Etha | 1998 |
The effect of genotype on sensitivity to inflammatory nociception: characterization of resistant (A/J) and sensitive (C57BL/6J) inbred mouse strains.
Topics: Animals; Formaldehyde; Genotype; Inflammation; Mice; Mice, Inbred A; Mice, Inbred C57BL; Pain; Pain | 1998 |
The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain.
Topics: Amides; Analgesics; Animals; Arachidonic Acids; Cannabinoids; Capillary Permeability; Cystitis; Elec | 1998 |
Attenuation of formalin-induced nociceptive behaviors following local peripheral injection of gabapentin.
Topics: Acetates; Amines; Analgesics; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Dose-Response | 1998 |
Involvement of nitric oxide in peripheral antinociception mediated by kappa- and delta-opioid receptors.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesics | 1998 |
The formalin test: a dose-response analysis at three developmental stages.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; | 1998 |
Antinociceptive effect of meloxicam, in neurogenic and inflammatory nociceptive models in mice.
Topics: Abdominal Muscles; Acetic Acid; Analgesics; Analgesics, Opioid; Animals; Capsaicin; Cyclooxygenase I | 1998 |
Induction of long-term potentiation at spinal synapses by noxious stimulation or nerve injury.
Topics: Animals; Denervation; Electric Stimulation; Evoked Potentials; Formaldehyde; Hot Temperature; Long-T | 1998 |
Heterogeneous neurochemical responses to different stressors: a test of Selye's doctrine of nonspecificity.
Topics: Adrenocorticotropic Hormone; Animals; Cold Temperature; Epinephrine; Formaldehyde; Handling, Psychol | 1998 |
A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala.
Topics: Afferent Pathways; Amygdala; Animals; Behavior, Animal; Disinfectants; Dose-Response Relationship, D | 1998 |
Formalin-induced nociception activates a monoaminergic descending inhibitory system.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Biogenic Monoamines; Formaldehyde; Male; Me | 1998 |
Systemic treatment with Mycobacterium bovis bacillus Calmette-Guérin (BCG) potentiates kinin B1 receptor agonist-induced nociception and oedema formation in the formalin test in mice.
Topics: Animals; Bradykinin; Dexamethasone; Dose-Response Relationship, Drug; Drug Synergism; Edema; Formald | 1998 |
Effects of novelty and pain on behavior and hippocampal extracellular ACh levels in male and female rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Exploratory Behavior; Extracellular Space; Female; For | 1999 |
Sympathectomy decreases formalin-induced nociceptive responses independent of changes in peripheral blood flow.
Topics: Animals; Behavior, Animal; Formaldehyde; Hindlimb; Injections, Intradermal; Male; Nociceptors; Pain; | 1999 |
The medullary dorsal reticular nucleus facilitates pain behaviour induced by formalin in the rat.
Topics: Animals; Autonomic Nervous System; Disinfectants; Formaldehyde; Male; Medulla Oblongata; Nociceptors | 1999 |
Temporal changes of preproenkephalin mRNA and leu-enkephalin-like immunoreactivity in the neurons of the caudal spinal trigeminal nucleus and upper cervical cord after noxious stimuli.
Topics: Animals; Enkephalin, Leucine; Enkephalins; Formaldehyde; Immunohistochemistry; In Situ Hybridization | 1998 |
Role of the kappa-opioid system in the attenuation of the morphine-induced place preference under chronic pain.
Topics: Animals; Chronic Disease; Conditioning, Psychological; Formaldehyde; Hindlimb; Inflammation; Male; M | 1999 |
Morphine reversed formalin-induced CA1 pyramidal cell suppression via an effect on septohippocampal neural processing.
Topics: Action Potentials; Animals; Disinfectants; Formaldehyde; Hippocampus; Male; Morphine; Naloxone; Narc | 1999 |
Intrathecal oxotremorine affects formalin-induced behavior and spinal nitric oxide synthase immunoreactivity in rats.
Topics: Animals; Behavior, Animal; Formaldehyde; Immunohistochemistry; Injections, Spinal; Male; Muscarinic | 1999 |
Effects of CCK antagonists on GABA mechanism-induced antinociception in the formalin test.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Baclofen; Dose-Response Relationship, Drug; F | 1999 |
Characterization of socio-psychological stress-induced antinociception in the formalin test in mice.
Topics: Analgesia; Animals; Electroshock; Formaldehyde; Male; Mice; Pain; Physical Stimulation; Social Envir | 1999 |
Distinct effect of intracerebroventricular and intrathecal injections of nociceptin/orphanin FQ in the rat formalin test.
Topics: Amino Acid Sequence; Analgesia; Animals; Formaldehyde; Injections, Intraventricular; Injections, Spi | 1999 |
CNS pattern of metabolic activity during tonic pain: evidence for modulation by beta-endorphin.
Topics: Animals; Antibodies; Antimetabolites; Behavior, Animal; beta-Endorphin; Blood Glucose; Central Nervo | 1999 |
Microglial reactions after subcutaneous formalin injection into the rat hind paw.
Topics: Animals; Antibodies, Monoclonal; Brain Stem; Complement C3b; Disinfectants; Formaldehyde; Hindlimb; | 1999 |
Effect of nocistatin and its interaction with nociceptin/orphanin FQ on the rat formalin test.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Formaldehyde; Hot Temperature; Inje | 1999 |
Algogenic mediator-induced nociceptive response in diabetic mice.
Topics: Animals; Benzylidene Compounds; Bradykinin; Diabetes Mellitus, Experimental; Dinoprost; Dose-Respons | 1999 |
Preprodynorphin-like immunoreactivity in medullary dorsal horn neurons projecting to the thalamic regions in the rat.
Topics: Animals; Dynorphins; Formaldehyde; Injections, Subcutaneous; Lip; Male; Neurons; Nociceptors; Pain; | 1999 |
A murine model for Down syndrome shows reduced responsiveness to pain.
Topics: Animals; Behavior, Animal; Disease Models, Animal; Down Syndrome; Escape Reaction; Formaldehyde; Hot | 1999 |
Antinociceptive effects of the ORL1 receptor agonist nociceptin/orphanin FQ in diabetic mice.
Topics: Animals; Capsaicin; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Formaldehyde; | 1999 |
Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine.
Topics: Administration, Oral; Animals; Behavior, Animal; Binding, Competitive; Central Nervous System; Forma | 1999 |
Alendronate induces antinociception in mice, not related with its effects in bone.
Topics: Acetic Acid; Alendronate; Analgesics; Animals; Bone Density; Dose-Response Relationship, Drug; Forma | 1999 |
Pre- versus postformalin effects of ketamine or large-dose alfentanil in the rat: discordance between pain behavior and spinal Fos-like immunoreactivity.
Topics: Alfentanil; Analgesics, Opioid; Animals; Formaldehyde; Ketamine; Male; Naloxone; Pain; Proto-Oncogen | 1999 |
Ginsenosides that produce differential antinociception in mice.
Topics: Acetic Acid; Analgesics; Animals; Body Temperature; Central Nervous System Agents; Dose-Response Rel | 1999 |
Facilitation of spinal sciatic neuron responses to hindpaw thermal stimulation after formalin injection in rat tail.
Topics: Animals; Formaldehyde; Hindlimb; Hot Temperature; Male; Neurons; Pain; Physical Stimulation; Rats; R | 1999 |
NMDA receptors mediating Fos expression in rat spinal cord induced by subcutaneous injection of formalin.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Neurons; | 1998 |
The effect of intrathecal gabapentin on pain behavior and hemodynamics on the formalin test in the rat.
Topics: Acetates; Amines; Animals; Behavior, Animal; Cyclohexanecarboxylic Acids; Dose-Response Relationship | 1999 |
Effect of tetrahydropalmatine analogs on Fos expression induced by formalin-pain.
Topics: Analgesics, Non-Narcotic; Animals; Berberine; Berberine Alkaloids; Brain; Dopamine Agonists; Dopamin | 1999 |
Spinal substance P receptor expression and internalization in acute, short-term, and long-term inflammatory pain states.
Topics: Acute Disease; Afferent Pathways; Animals; Carrageenan; Chronic Disease; Formaldehyde; Freund's Adju | 1999 |
Opioidergic and adrenergic modulation of formalin-evoked spinal c-fos mRNA expression and nocifensive behavior in the rat.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Animals; Formaldehyde; Inflammation; Inflammati | 1999 |
Antinociception produced by systemic, spinal and supraspinal administration of amiloride in mice.
Topics: Acetic Acid; Amiloride; Animals; Animals, Newborn; Behavior, Animal; Capsaicin; Disease Models, Anim | 1999 |
Primary hyperalgesia to mechanical and heat stimuli following subcutaneous bee venom injection into the plantar surface of hindpaw in the conscious rat: a comparative study with the formalin test.
Topics: Animals; Bee Venoms; Disease Models, Animal; Formaldehyde; Hindlimb; Hot Temperature; Hyperalgesia; | 1999 |
Pain modulation by release of the endogenous cannabinoid anandamide.
Topics: Analgesia; Animals; Arachidonic Acids; Calcium Channel Blockers; Cannabinoids; Electrophysiology; En | 1999 |
Lesions of the dorsolateral funiculus block supraspinal opioid delta receptor mediated antinociception in the rat.
Topics: Animals; Brain Mapping; Cerebral Ventricles; Formaldehyde; Injections, Intraventricular; Male; Medul | 1999 |
Oral antinociception and oedema inhibition produced by NPC 18884, a non-peptidic bradykinin B2 receptor antagonist.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Behavior, Animal; Bradykinin; Bradykinin Rec | 1999 |
Effects of forced walking stress on formalin-induced paw licking in mice.
Topics: Analgesia; Animals; Behavior, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitat | 1999 |
Changes in beta-endorphin and stress-induced analgesia in mice after exposure to forced walking stress.
Topics: Analgesia; Animals; Behavior, Animal; beta-Endorphin; Brain; Formaldehyde; Humans; Male; Mice; Pain; | 1999 |
Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity.
Topics: Animals; Capsaicin; Enzyme Activation; Formaldehyde; Hindlimb; In Vitro Techniques; Male; MAP Kinase | 1999 |
Nociceptive regulation of GABA(B) receptor gene expression in rat spinal cord.
Topics: Animals; Fixatives; Formaldehyde; Ganglia, Spinal; Gene Expression; Male; Nociceptors; Pain; Rats; R | 1999 |
The systemically administered competitive AMPA receptor antagonist, YM872, has analgesic effects on thermal or formalin-induced pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; Behavior, Animal; Binding, Competitive; Formaldehyde; Hot Tempera | 1999 |
Effects of formalin pain on hippocampal c-Fos expression in male and female rats.
Topics: Analysis of Variance; Animals; Dentate Gyrus; Estrus; Female; Formaldehyde; Hippocampus; Immunohisto | 1999 |
Evidence for the involvement of spinal endogenous ATP and P2X receptors in nociceptive responses caused by formalin and capsaicin in mice.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Capsaicin; Formaldehyde; Male; Mice; Motor Activi | 1999 |
Antinociceptive effects of the tubercles of Anredera leptostachys.
Topics: Acetic Acid; Analgesics; Animals; Behavior, Animal; Caribbean Region; Diazepam; Dose-Response Relati | 1999 |
Expression and action of cyclic GMP-dependent protein kinase Ialpha in inflammatory hyperalgesia in rat spinal cord.
Topics: Animals; Antibodies; Behavior, Animal; Cyclic GMP; Cyclic GMP-Dependent Protein Kinase Type I; Cycli | 2000 |
Role of gonadal hormones in formalin-induced pain responses of male rats: modulation by estradiol and naloxone administration.
Topics: Animals; Behavior, Animal; Corticosterone; Disinfectants; Estradiol; Formaldehyde; Hypothalamo-Hypop | 2000 |
Interactions of intrathecally administered ziconotide, a selective blocker of neuronal N-type voltage-sensitive calcium channels, with morphine on nociception in rats.
Topics: Analgesics, Opioid; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Drug Administration | 2000 |
Tachykinin receptor inhibition and c-Fos expression in the rat brain following formalin-induced pain.
Topics: Analgesics; Animals; Behavior, Animal; Benzamides; Brain; Formaldehyde; Grooming; Indoles; Injection | 2000 |
The involvement of dopamine in nociception: the role of D(1) and D(2) receptors in the dorsolateral striatum.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Corpus Striatum; Dopamine; Dopa | 2000 |
Elevated substance-P-like immunoreactivity levels in spinal dialysates during the formalin test in normal and diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Formaldehyde; Hindlimb; Hot Tempera | 2000 |
The bee venom test: comparisons with the formalin test with injection of different venoms.
Topics: Animals; Bee Venoms; Formaldehyde; Mice; Pain; Pain Measurement; Wasp Venoms | 2000 |
Knock down of spinal NMDA receptors reduces NMDA and formalin evoked behaviors in rat.
Topics: Animals; Behavior, Animal; Blotting, Western; Dose-Response Relationship, Drug; Excitatory Amino Aci | 2000 |
Gonadectomy and persistent pain differently affect hippocampal c-Fos expression in male and female rats.
Topics: Analysis of Variance; Animals; Castration; Dentate Gyrus; Female; Formaldehyde; Gene Expression Regu | 2000 |
Effects of the I(1) imidazoline/alpha(2)-adrenergic receptor agonist moxonidine in comparison with clonidine in the formalin test in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agon | 2000 |
Periaqueductal gray matter metabotropic glutamate receptors modulate formalin-induced nociception.
Topics: Animals; Behavior, Animal; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Formal | 2000 |
Involvement of M3 muscarinic receptors of the spinal cord in formalin-induced nociception in mice.
Topics: Acetylcholine; Animals; Atropine; Cholinergic Agents; Cholinesterase Inhibitors; Formaldehyde; Hemic | 2000 |
Role of histamine H(1) receptor in pain perception: a study of the receptor gene knockout mice.
Topics: Animals; Behavior, Animal; Capsaicin; Chlorpheniramine; Formaldehyde; Histamine H1 Antagonists; Hot | 2000 |
The effect of neonatal capsaicin on the c-Fos-like immunoreactivity induced in subnucleus oralis neurons by noxious intraoral stimulation.
Topics: Animals; Animals, Newborn; Calcitonin Gene-Related Peptide; Capsaicin; Dental Pulp; Electric Stimula | 2000 |
Phosphorylated cAMP response element binding protein increases in neurokinin-1 receptor-immunoreactive neurons in rat spinal cord in response to formalin-induced nociception.
Topics: Animals; Cyclic AMP Response Element-Binding Protein; Fluorescent Antibody Technique; Formaldehyde; | 2000 |
Formalin-induced central sensitization in the rat: somatosensory evoked potential data.
Topics: Animals; Cerebral Cortex; Electric Stimulation; Evoked Potentials, Somatosensory; Formaldehyde; Hype | 2000 |
The role of formalin-induced pain in morphine tolerance, withdrawal, and reward.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Drug Tolerance; For | 2000 |
Activity of p44/42 MAP kinase in the caudal subnucleus of trigeminal spinal nucleus is increased following perioral noxious stimulation in the mouse.
Topics: Animals; Fixatives; Formaldehyde; Male; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinase | 2000 |
Heme oxygenase type 2 plays a role in formalin-induced nociception.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Heme Oxygenase (Decyclizi | 2000 |
Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive action of meloxicam in the formalin test.
Topics: Analgesics, Non-Narcotic; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; | 2000 |
Yohimbine produces antinociception in the formalin test in rats: involvement of serotonin(1A) receptors.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adrenergic alpha-Antagonists; Animals; Benzofurans; Bridged | 2000 |
Altered pain responses in mice lacking alpha 1E subunit of the voltage-dependent Ca2+ channel.
Topics: Acetic Acid; Animals; Anxiety; Calcium; Calcium Channels, R-Type; Exploratory Behavior; Fear; Formal | 2000 |
Interaction between intrathecal morphine and glutamate receptor antagonists in formalin test.
Topics: 2-Amino-5-phosphonovalerate; Analgesics, Opioid; Animals; Behavior, Animal; Dose-Response Relationsh | 2000 |
The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats.
Topics: Animals; Dinoprostone; Dizocilpine Maleate; Excitatory Amino Acids; Formaldehyde; Hyperalgesia; Indo | 2000 |
Analysis of the antinociceptive properties of marrubiin isolated from Marrubium vulgare.
Topics: Abdominal Pain; Acetic Acid; Analgesics; Animals; Brazil; Capsaicin; Diterpenes; Female; Formaldehyd | 2000 |
Complications following formalin installation in the treatment of radiation induced proctitis.
Topics: Aged; Aged, 80 and over; Fecal Incontinence; Female; Formaldehyde; Gastrointestinal Hemorrhage; Huma | 2000 |
Phenacetin, acetaminophen and dipyrone: analgesic and rewarding effects.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Dipyrone; Disinfectants; Dose-Re | 2000 |
Toward a new anti-inflammatory and analgesic agent.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Bradykinin Receptor Antagonists; Capsaicin; Cyclooxyg | 2000 |
Studies on the anti-inflammatory, antipyretic and analgesic properties of Alstonia boonei stem bark.
Topics: Acetic Acid; Africa; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Art | 2000 |
kappa -opioid receptor agonists modulate visceral nociception at a novel, peripheral site of action.
Topics: Acetamides; Analgesics, Opioid; Animals; Colon; Disinfectants; Electrophysiology; Enkephalin, Ala(2) | 2000 |
Noxious stimulation increases glutamate and arginine in the periaqueductal gray matter in rats: a microdialysis study.
Topics: Animals; Arginine; Fixatives; Formaldehyde; Glutamic Acid; Hindlimb; Male; Microdialysis; Pain; Pain | 2000 |
Differential involvement of opioid receptors in stress-induced antinociception caused by repeated exposure to forced walking stress in mice.
Topics: Animals; Formaldehyde; Male; Mice; Naloxone; Naltrexone; Narcotic Antagonists; Pain; Pain Measuremen | 2000 |
Interaction of pentazocine with calcium channel blocking drugs during chemical and thermal pain in mice.
Topics: Analgesics, Opioid; Animals; Benzomorphans; Calcium Channel Blockers; Drug Interactions; Drug Tolera | 2000 |
Pharmacological validation of an automated method of pain scoring in the formalin test in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Automation; Beh | 1999 |
Antinociceptive properties of extracts of new species of plants of the genus Phyllanthus (Euphorbiaceae).
Topics: Abdomen; Acetic Acid; Analgesics; Animals; Behavior, Animal; Brazil; Capsaicin; Euphorbiaceae; Forma | 2000 |
Fine topography of brain areas activated by cold stress. A fos immunohistochemical study in rats.
Topics: Animals; Brain; Brain Chemistry; Catecholamines; Cold Temperature; Formaldehyde; Genes, fos; Immunoh | 2000 |
Diurnal variations in tonic pain reactions in mice.
Topics: Animals; Circadian Rhythm; Female; Formaldehyde; Mice; Mice, Inbred CBA; Pain; Temperature | 2000 |
Brainstem noradrenergic control of nociception is abnormal in the spontaneously hypertensive rat.
Topics: Analysis of Variance; Animals; Antibodies, Monoclonal; Behavior, Animal; Blood Pressure; Brain Stem; | 2000 |
Effects of different concentrations and volumes of formalin on pain response in rats.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Male; Pain; Pain Measurement; Rats; Rats, S | 2000 |
Antinociceptive activity of a hydroalcoholic extract obtained from aerial parts of Sebastiania schottiana (Euphorbiaceae).
Topics: Acetates; Analgesics; Animals; Capsaicin; Euphorbiaceae; Formaldehyde; Mice; Pain; Pain Measurement; | 2000 |
Effect of imipramine on tolerance to morphine antinociception in the formalin test.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Disinfectants; | 2000 |
ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat.
Topics: Adenosine Kinase; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, | 2000 |
Relationship between nociceptor activity, peripheral edema, spinal microglial activation and long-term hyperalgesia induced by formalin.
Topics: Anesthetics, Local; Animals; Behavior, Animal; Bupivacaine; Chronic Disease; Dose-Response Relations | 2000 |
Modulation of BzATP and formalin induced nociception: attenuation by the P2X receptor antagonist, TNP-ATP and enhancement by the P2X(3) allosteric modulator, cibacron blue.
Topics: Adenosine Triphosphate; Animals; Dose-Response Relationship, Drug; Fluorescent Dyes; Formaldehyde; I | 2001 |
Genetic enhancement of inflammatory pain by forebrain NR2B overexpression.
Topics: Animals; Encephalitis; Formaldehyde; Freund's Adjuvant; Hindlimb; Injections; Male; Mice; Mice, Tran | 2001 |
Analgesic and anti-inflammatory effects of Mangifera indica L. extract (Vimang).
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Carrageenan; Dose-Response Relationship, | 2001 |
Antinociceptive properties of N-aryl-glutaramic acids and N-aryl-glutarimides.
Topics: Acetic Acid; Analgesics; Aspirin; Chromatography, Thin Layer; Formaldehyde; Glutamic Acid; Humans; I | 2000 |
Pharmacological activity and chemical composition of callus culture extracts from selected species of Phyllanthus.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Brazil; Cultur | 2000 |
Antinociceptive pattern of flavone and its mechanism as tested by formalin assay.
Topics: Analgesics; Animals; Flavones; Flavonoids; Formaldehyde; Glucose; Male; Mice; Opioid Peptides; Pain; | 2000 |
Antinociceptive effect of spinally injected L-NAME on the acute nociceptive response induced by low concentrations of formalin.
Topics: Analgesics; Animals; Enzyme Inhibitors; Formaldehyde; Injections, Spinal; Male; Mice; NG-Nitroargini | 2001 |
Antinociceptive interaction between spinal clonidine and lidocaine in the rat formalin test: an isobolographic analysis.
Topics: Adrenergic alpha-Agonists; Anesthetics, Local; Animals; Calcium Channels; Clonidine; Dose-Response R | 2001 |
The antinociceptive effect of intrathecal administration of epibatidine with clonidine or neostigmine in the formalin test in rats.
Topics: Analgesics; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Bridged Bicyclo Compounds, Heterocy | 2001 |
Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Carrageenan; F | 2001 |
Effect of VMH lesion on sucrose-fed analgesia in formalin pain.
Topics: Analgesia; Animals; Disinfectants; Formaldehyde; Hypothalamus; Male; Pain; Rats; Sucrose | 2001 |
Potent anti-inflammatory activities of hydroalcoholic extract from aerial parts of Stachys inflata on rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Dose-Response Relationship, Drug; Ede | 2001 |
Effects of paeoniflorin on the formalin-induced nociceptive behaviour in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoates; Bridged-Ring Compounds; Dose-Response R | 2001 |
Structure-antinociceptive activity studies of incarvillateine, a monoterpene alkaloid from Incarvillea sinensis.
Topics: Alkaloids; Analgesics; Animals; Azabicyclo Compounds; Coumaric Acids; Disease Models, Animal; Formal | 2001 |
Effects of rapid eye movement (REM) sleep deprivation on pain sensitivity in the rat.
Topics: Animals; Behavior, Animal; Electric Stimulation; Formaldehyde; Hot Temperature; Immersion; Male; Noc | 2001 |
Sildenafil increases diclofenac antinociception in the formalin test.
Topics: Analgesics; Animals; Cyclooxygenase Inhibitors; Diclofenac; Dose-Response Relationship, Drug; Drug S | 2001 |
Suppression of inflammatory and neuropathic pain symptoms in mice lacking the N-type Ca2+ channel.
Topics: Acetic Acid; Acoustic Stimulation; Animals; Anxiety; Behavior, Animal; Calcium Channel Blockers; Cal | 2001 |
[Effects of morphine on the formalin induced IL-2R beta mRNA expression of rat hippocampus].
Topics: Adrenocorticotropic Hormone; Animals; Formaldehyde; Gene Expression; Hippocampus; Morphine; Nocicept | 1998 |
Characterization of EP receptor subtypes responsible for prostaglandin E2-induced pain responses by use of EP1 and EP3 receptor knockout mice.
Topics: Animals; Arginine; Behavior, Animal; Dinoprostone; Formaldehyde; Gene Deletion; Hyperalgesia; Mice; | 2001 |
Effects of gonadal hormones and persistent pain on non-spatial working memory in male and female rats.
Topics: Animals; Behavior, Animal; Corticosterone; Feces; Female; Form Perception; Formaldehyde; Male; Maze | 2001 |
Antinociceptive effects of bee venom acupuncture (apipuncture) in rodent animal models: a comparative study of acupoint versus non-acupoint stimulation.
Topics: Acetic Acid; Acupuncture Points; Acupuncture Therapy; Analgesics; Animals; Bee Venoms; Dose-Response | 2001 |
Antinociceptive activity of Zizyphus spina-christi root bark extract.
Topics: Acetic Acid; Analgesics; Animals; Dose-Response Relationship, Drug; Female; Formaldehyde; Hot Temper | 2001 |
Differential roles of spinal cholera toxin- and pertussis toxin-sensitive G proteins in nociceptive responses caused by formalin, capsaicin, and substance P in mice.
Topics: Animals; Behavior, Animal; Capsaicin; Cholera Toxin; Dose-Response Relationship, Drug; Drug Interact | 2001 |
In the formalin model of tonic nociceptive pain, 8-OH-DPAT produces 5-HT1A receptor-mediated, behaviorally specific analgesia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Behavior, Animal; Dose-Response Relation | 2001 |
Interactions of inflammatory pain and morphine in infant rats: long-term behavioral effects.
Topics: Alcohol Drinking; Animals; Animals, Newborn; Arousal; Chronic Disease; Female; Formaldehyde; Inflamm | 2001 |
Antisera against endogenous opioids increase the nocifensive response to formalin: demonstration of inhibitory beta-endorphinergic control.
Topics: Animals; beta-Endorphin; Dynorphins; Enkephalin, Leucine; Enkephalin, Methionine; Formaldehyde; Immu | 2001 |
Antinociceptive action of amlodipine blocking N-type Ca2+ channels at the primary afferent neurons in mice.
Topics: Amlodipine; Analgesics; Animals; Calcium Channel Blockers; Dose-Response Relationship, Drug; Electro | 2001 |
Antinociceptive activity of the endogenous fatty acid amide, palmitylethanolamide.
Topics: Amides; Analgesics; Analysis of Variance; Animals; Arachidonic Acids; Calcium Channel Blockers; Camp | 2001 |
Evaluation of the anti-inflammatory and analgesic properties of Chasmanthera dependens leaf methanol extract.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capillary P | 2001 |
Effects of 5-HT2 and 5-HT3 receptors on the modulation of nociceptive transmission in rat spinal cord according to the formalin test.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Dose-Response Relationship, Drug; For | 2001 |
Synergistic effects between intrathecal clonidine and neostigmine in the formalin test.
Topics: Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Animals; Cholinesterase Inhibitors; Clonidine; | 2001 |
Structure-activity study and analgesic efficacy of amino acid derivatives as N-type calcium channel blockers.
Topics: Amino Acids; Analgesics; Animals; Calcium Channel Blockers; Calcium Channels, N-Type; Disease Models | 2001 |
B vitamins induce an antinociceptive effect in the acetic acid and formaldehyde models of nociception in mice.
Topics: Acetic Acid; Animals; Constriction; Disease Models, Animal; Dose-Response Relationship, Drug; Edema; | 2001 |
Identification of a new class of molecules, the arachidonyl amino acids, and characterization of one member that inhibits pain.
Topics: Alanine; Amidohydrolases; Amino Acids; Animals; Arachidonic Acid; Arachidonic Acids; Brain; Calcium; | 2001 |
Facilitation of enkephalins catabolism inhibitor-induced antinociception by drugs classically used in pain management.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experim | 2001 |
The synergistic interaction between midazolam and clonidine in spinally-mediated analgesia in two different pain models of rats.
Topics: Adrenergic alpha-Agonists; Analgesia; Anesthetics, Intravenous; Animals; Behavior, Animal; Clonidine | 2001 |
Effect of prenatal stress on tonic pain in rats.
Topics: Animals; Behavior, Animal; Female; Formaldehyde; Male; Maternal-Fetal Exchange; Pain; Pain Measureme | 2001 |
Blocking NMDA receptors in the hippocampal dentate gyrus with AP5 produces analgesia in the formalin pain test.
Topics: 2-Amino-5-phosphonovalerate; Analgesia; Animals; Behavior, Animal; Dentate Gyrus; Disease Models, An | 2001 |
Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E(2) release in the spinal cord.
Topics: Animals; Behavior, Animal; Celecoxib; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitor | 2001 |
In vivo evidence for a role of protein kinase C in peripheral nociceptive processing.
Topics: Alkaloids; Animals; Benzophenanthridines; Bradykinin; Dose-Response Relationship, Drug; Enzyme Inhib | 2002 |
Analgesic effect of B vitamins in formalin-induced inflammatory pain.
Topics: Animals; Behavior, Animal; Female; Formaldehyde; Inflammation; Naloxone; Narcotic Antagonists; Pain; | 2001 |
Participation of COX, IL-1 beta and TNF alpha in formalin-induced inflammatory pain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Blocking; Celecoxib; Cyclooxygenase In | 2001 |
Spinal substance P immunoreactivity is enhanced by acute chemical stimulation of the rat prostate.
Topics: Adrenergic alpha-Antagonists; Animals; Fixatives; Formaldehyde; Lumbar Vertebrae; Male; Pain; Prosta | 2002 |
Evaluation of Lewis and SHR rat strains as a genetic model for the study of anxiety and pain.
Topics: Animals; Anxiety; Blood Pressure; Disease Models, Animal; Female; Formaldehyde; Lighting; Male; Pain | 2002 |
Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord.
Topics: Amitriptyline; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Formaldehyde; Injections, Intrap | 2002 |
Effects of different concentrations of formalin on paw edema and pain behaviors in rats.
Topics: Animals; Behavior, Animal; Edema; Extremities; Formaldehyde; Male; Pain; Rats; Rats, Sprague-Dawley | 2002 |
Magnesium increases morphine analgesic effect in different experimental models of pain.
Topics: Analgesics, Opioid; Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Drug Synergism; | 2002 |
Responses of superficial dorsal horn neurons to intradermal serotonin and other irritants: comparison with scratching behavior.
Topics: Animals; Behavior, Animal; Capsaicin; Disinfectants; Electrophysiology; Formaldehyde; Histamine; Inj | 2002 |
Subcutaneous formalin and intraplantar carrageenan increase nitric oxide release as measured by in vivo voltammetry in the spinal cord.
Topics: Animals; Carrageenan; Excitatory Amino Acid Antagonists; Formaldehyde; Inflammation; Inflammation Me | 2002 |
Effect of alpha-adrenoceptor agonists and antagonists on imipramine-induced antinociception in the rat formalin test.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antidepressive Agents, Tricyclic; | 2002 |
Pharmacological evidence for the activation of K(+) channels by diclofenac.
Topics: 4-Aminopyridine; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; A | 2002 |
The role of cyclooxygenase-1 and -2 in the rat formalin test.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 1; | 2002 |
The interaction between gabapentin and amitriptyline in the rat formalin test after systemic administration.
Topics: Acetates; Amines; Amitriptyline; Analgesics; Analgesics, Non-Narcotic; Animals; Behavior, Animal; Cy | 2002 |
[Propofol depresses c -fos expression of NOS neurons in the spinal cord of rats with inflammatory pain].
Topics: Animals; Female; Formaldehyde; Male; Neurons; Nitric Oxide Synthase; Pain; Propofol; Proto-Oncogene | 2002 |
[Increased expression of formalin-induced Fos and NADPH-d positive neurons in the spinal cord of morphine-tolerant rats].
Topics: Animals; Drug Tolerance; Formaldehyde; Male; Morphine; NADPH Dehydrogenase; Neurons; Nitric Oxide Sy | 2000 |
[Effect of ACTH on the expression of somatostatin and c-fos in the spinal cord and formalin evoked pain response].
Topics: Adrenocorticotropic Hormone; Animals; Cyproheptadine; Female; Formaldehyde; Immunohistochemistry; Ma | 1999 |
Investigations on the antinociceptive activity of crude extracts from Croton cajucara leaves in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Animals; Dose-Response Relationship, Drug; Euphorbiac | 2002 |
Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test.
Topics: Analgesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, Animal; Celecoxib; Cyclooxyge | 2002 |
Effects of somatosensory cortical stimulation on expression of c-Fos in rat medullary dorsal horn in response to formalin-induced noxious stimulation.
Topics: Animals; Cerebral Cortex; Electric Stimulation; Fixatives; Formaldehyde; Gene Expression Regulation; | 2002 |
Isobolographic analysis of the analgesic interactions between ketamine and tramadol.
Topics: Analgesics; Animals; Behavior, Animal; Central Nervous System; Dose-Response Relationship, Drug; Dru | 2002 |
Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Anesthesia; Animals; Edema; Formaldehyde; Hot Temper | 2002 |
Exposure to the estrogenic pollutant bisphenol A affects pain behavior induced by subcutaneous formalin injection in male and female rats.
Topics: Animals; Benzhydryl Compounds; Corticosterone; Environmental Pollutants; Estradiol; Estrogens, Non-S | 2002 |
Elevated spinal cyclooxygenase and prostaglandin release during hyperalgesia in diabetic rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Body Weight; Cyclooxygenase 1; Cycl | 2002 |
Comparison of protection by L-ascorbic acid, L-cysteine, and adrenergic-blocking agents against acetaldehyde, acrolein, and formaldehyde toxicity: implications in smoking.
Topics: Acetaldehyde; Acrolein; Adrenergic beta-Antagonists; Aldehydes; Anesthesia; Animals; Ascorbic Acid; | 1979 |
Naloxone reversal of morphine analgesia but failure to alter reactivity to pain in the formalin test.
Topics: Analgesia; Animals; Formaldehyde; Male; Morphine; Naloxone; Pain; Rats; Reaction Time; Receptors, Op | 1978 |
The pituitary gland mediates acute and chronic pain responsiveness in stressed and non-stressed rats.
Topics: Adrenocorticotropic Hormone; Animals; Formaldehyde; Hypophysectomy; Male; Motor Activity; Pain; Pitu | 1979 |
A test for analgesics as an indicator of locomotor activity in writhing mice.
Topics: Acetates; Aminopyrine; Analgesics; Animals; Drug Interactions; Formaldehyde; Male; Mice; Morphine; M | 1979 |
[Experimental method for the quantitative assesment of the pain reaction occuring to the injection of drug preparations].
Topics: Animals; Dose-Response Relationship, Drug; Foot; Formaldehyde; Injections; Methods; Mice; Motor Acti | 1977 |
The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats.
Topics: Animals; Behavior, Animal; Brain Stem; Cats; Drug Evaluation; Forelimb; Formaldehyde; Injections, Su | 1977 |
Self-mutilation after dorsal rhizotomy in rats: effects of prior pain and pattern of root lesions.
Topics: Anesthesia; Animals; Behavior, Animal; Extremities; Formaldehyde; Humans; Motor Activity; Pain; Rats | 1979 |
Intrathecal co-administration of substance P and NMDA augments nociceptive responses in the formalin test.
Topics: Animals; Formaldehyde; Injections, Spinal; Male; Mice; N-Methylaspartate; Nociceptors; Pain; Pain Me | 1992 |
Stress-induced analgesia prevents the development of the tonic, late phase of pain produced by subcutaneous formalin.
Topics: Analgesia; Animals; Dizocilpine Maleate; Formaldehyde; Injections, Subcutaneous; Male; Mice; Naloxon | 1992 |
The non-peptide NK1 receptor antagonist, (+/-)-CP-96,345, produces antinociceptive and anti-oedema effects in the rat.
Topics: Analgesics; Animals; Behavior, Animal; Biphenyl Compounds; Carrageenan; Edema; Formaldehyde; Male; P | 1992 |
Systemic injections of alpha-1 adrenergic agonists produce antinociception in the formalin test.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Dose-Response Relation | 1992 |
The effects of sandostatin and somatostatin on nociceptive transmission in the dorsal horn of the rat spinal cord.
Topics: Animals; Electric Stimulation; Formaldehyde; Neurons; Octreotide; Pain; Rats; Rats, Sprague-Dawley; | 1992 |
NMDA receptor antagonist MK-801 blocks non-opioid stress-induced analgesia in the formalin test.
Topics: Analgesia; Animals; Dizocilpine Maleate; Formaldehyde; Male; Mice; Mice, Inbred Strains; Morphine; N | 1992 |
Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Behavior, Animal; Blood Pres | 1992 |
Intrathecal midazolam versus intrathecal morphine in orofacial nociception: an experimental study in rats.
Topics: Animals; Facial Pain; Formaldehyde; Injections, Spinal; Male; Midazolam; Morphine; Mouth; Nociceptor | 1992 |
Differential antinociceptive effects of morphine and methylmorphine in the formalin test.
Topics: Analgesics; Animals; Codeine; Dose-Response Relationship, Drug; Formaldehyde; Injections, Intraventr | 1992 |
The differential effects of lateral midbrain lesions on the two phases of formalin pain.
Topics: Animals; Female; Formaldehyde; Hindlimb; Mesencephalon; Pain; Rats; Rats, Wistar; Time Factors | 1992 |
Effect of subcutaneous administration of the chemical algogen formalin, on 5-HT metabolism in the nucleus raphe magnus and the medullary dorsal horn: a voltammetric study in freely moving rats.
Topics: Animals; Electrochemistry; Formaldehyde; Injections, Subcutaneous; Male; Movement; Pain; Raphe Nucle | 1992 |
The behavioral response to formalin in preweanling rats.
Topics: Animals; Animals, Suckling; Behavior, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde | 1992 |
Formalin pain is expressed in decerebrate rats but not attenuated by morphine.
Topics: Animals; Behavior, Animal; Brain Stem; Decerebrate State; Formaldehyde; Morphine; Muscle Tonus; Pain | 1992 |
Analgesic and aversive effects of naloxone in BALB/c mice.
Topics: Analgesia; Animals; Choice Behavior; Dose-Response Relationship, Drug; Formaldehyde; Mice; Mice, Inb | 1992 |
Infusions of 6-hydroxydopamine into the nucleus accumbens abolish the analgesic effect of amphetamine but not of morphine in the formalin test.
Topics: Analgesics; Animals; Dextroamphetamine; Dopamine; Formaldehyde; Hydroxydopamines; Infusions, Parente | 1992 |
Analgesia for tonic pain by self-administered lateral hypothalamic stimulation.
Topics: Analgesia; Animals; Electric Stimulation; Female; Formaldehyde; Hypothalamic Area, Lateral; Nocicept | 1992 |
Analgesia produced by lidocaine microinjection into the dentate gyrus.
Topics: Analgesics; Animals; Formaldehyde; Hippocampus; Injections, Subcutaneous; Lidocaine; Male; Microinje | 1992 |
Temporal processes of formalin pain: differential role of the cingulum bundle, fornix pathway and medial bulboreticular formation.
Topics: Animals; Efferent Pathways; Formaldehyde; Gyrus Cinguli; Hippocampus; Injections; Lidocaine; Male; P | 1992 |
Amitriptyline produces analgesia in the formalin pain test.
Topics: Amitriptyline; Analgesia; Analgesics; Analysis of Variance; Animals; Formaldehyde; Male; Pain; Rats; | 1992 |
Effects of calcium channel blockers on formalin-induced nociception and inflammation in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Calcium Channel Blockers; Diltiazem; F | 1992 |
The antinociceptive action of supraspinal opioids results from an increase in descending inhibitory control: correlation of nociceptive behavior and c-fos expression.
Topics: Amino Acid Sequence; Animals; Behavior, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Fo | 1991 |
Dopamine receptor subtypes and formalin test analgesia.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Analgesia; Animals; Apomorphine; Benzaze | 1991 |
Systemic morphine suppresses noxious stimulus-evoked Fos protein-like immunoreactivity in the rat spinal cord.
Topics: Animals; Dose-Response Relationship, Drug; Formaldehyde; Immunologic Techniques; Male; Morphine; Pai | 1990 |
Formalin nociception in the mouse does not lead to increased spinal serotonin turnover.
Topics: Animals; Disease Models, Animal; Formaldehyde; Hydroxyindoleacetic Acid; Male; Mice; Mice, Inbred IC | 1990 |
Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord.
Topics: Animals; Capsaicin; Cysteamine; Drug Interactions; Formaldehyde; Mice; Pain; Pain Measurement; Somat | 1990 |
Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model.
Topics: 2-Amino-5-phosphonovalerate; Analgesics; Animals; Dose-Response Relationship, Drug; Formaldehyde; In | 1991 |
Release of substance P into the superficial dorsal horn following nociceptive activation of the hindpaw of the rat.
Topics: Animals; Formaldehyde; Hindlimb; Kinetics; Pain; Rats; Spinal Cord; Substance P; Time Factors | 1991 |
Sequential expression of JUN B, JUN D and FOS B proteins in rat spinal neurons: cascade of transcriptional operations during nociception.
Topics: Animals; Formaldehyde; Gene Expression Regulation; Hot Temperature; Immunohistochemistry; Male; Neur | 1991 |
Systemic capsaicin and olvanil reduce the acute algogenic and the late inflammatory phase following formalin injection into rodent paw.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsaicin; Electrophysiology; Foot; Formaldehyde; | 1991 |
Analgesia for formalin-induced pain by lateral hypothalamic stimulation.
Topics: Analgesia; Animals; Electric Stimulation; Electrodes; Electroshock; Female; Formaldehyde; Hypothalam | 1991 |
Analgesic effects of S and R isomers of the novel 5-HT3 receptor antagonists ADR-851 and ADR-882 in rats.
Topics: Analgesics; Animals; Behavior, Animal; Benzofurans; Bridged Bicyclo Compounds; Bridged Bicyclo Compo | 1991 |
Hyperbaric exposure and morphine alter the pattern of behavior in the formalin test.
Topics: Air Pressure; Animals; Atmosphere Exposure Chambers; Behavior, Animal; Dose-Response Relationship, D | 1991 |
The effect of pain on pentylenetetrazol induced seizures.
Topics: Animals; Formaldehyde; Male; Pain; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1991 |
Responses of trigeminal subnucleus oralis nociceptive neurones to subcutaneous formalin in the rat.
Topics: Animals; Brain Stem; Evoked Potentials; Formaldehyde; Injections, Subcutaneous; Male; Membrane Poten | 1991 |
Standardization of the rat paw formalin test for the evaluation of analgesics.
Topics: Analgesics; Animals; Aspirin; Behavior, Animal; Decerebrate State; Foot; Formaldehyde; Male; Morphin | 1991 |
Conditional hypoalgesia is attenuated by naltrexone applied to the periaqueductal gray.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Electroshock; Female; Formaldehyde; Microinjection | 1990 |
beta-Funaltrexamine antagonizes the analgesic effects of mu and kappa agonists in the formalin test.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; D | 1990 |
Evidence for spinal N-methyl-D-aspartate receptor involvement in prolonged chemical nociception in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dibenzocycloheptenes; Dipeptides; Dizocilpine Maleate; Electri | 1990 |
Central beta-endorphin system involvement in the reaction to acute tonic pain.
Topics: Acute Disease; Animals; Behavior, Animal; beta-Endorphin; Brain; Formaldehyde; Grooming; Male; Motor | 1991 |
Morphine decreases cerebral glucose utilization in limbic and forebrain regions while pain has no effect.
Topics: Animals; Autoradiography; Blood Gas Analysis; Blood Pressure; Brain Chemistry; Deoxyglucose; Dose-Re | 1991 |
L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse.
Topics: Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Blood Pressure; Brain Chemist | 1991 |
The antinociceptive effects of anterior pretectal stimulation in tests using thermal, mechanical and chemical noxious stimuli.
Topics: Animals; Brain; Formaldehyde; Hot Temperature; Injections, Subcutaneous; Male; Morphine; Nociceptors | 1991 |
Morphine hyperalgesic effects on the formalin test in domestic fowl (Gallus gallus).
Topics: Animals; Behavior, Animal; Chickens; Conditioning, Operant; Formaldehyde; Male; Morphine; Naloxone; | 1991 |
6-Hydroxydopamine lesions of the ventral tegmentum abolish D-amphetamine and morphine analgesia in the formalin test but not in the tail flick test.
Topics: Analgesia; Animals; Corpus Striatum; Dextroamphetamine; Dopamine; Formaldehyde; Hydroxydopamines; Ma | 1990 |
Tonic nociception in neonatal rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; | 1990 |
Further studies of the effects of intranigral morphine on behavioral responses to noxious stimuli.
Topics: Animals; Formaldehyde; Male; Mesencephalon; Microinjections; Morphine; Pain; Periaqueductal Gray; Ps | 1990 |
Analgesia produced by intrathecal administration of the kappa opioid agonist, U-50,488H, on formalin-evoked cutaneous pain in the rat.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Analgesia; | 1990 |
The rat paw formalin test: comparison of noxious agents.
Topics: Acetates; Acetic Acid; Animals; Carrageenan; Formaldehyde; Male; Nociceptors; Pain; Rats; Rats, Inbr | 1990 |
Diazepam attenuates morphine antinociception test-dependently in mice.
Topics: Analgesics; Animals; Behavior, Animal; Diazepam; Dose-Response Relationship, Drug; Formaldehyde; Mal | 1990 |
Subcutaneous formalin induces a segmental release of Met-enkephalin-like material from the rat spinal cord.
Topics: Animals; Enkephalin, Methionine; Formaldehyde; Injections, Subcutaneous; Lumbosacral Region; Male; N | 1990 |
Regulatory mechanisms for substance P in the dorsal horn during a nociceptive stimulus: axoplasmic transport vs electrical activity.
Topics: Animals; Axonal Transport; Colchicine; Electrophysiology; Female; Formaldehyde; Nociceptors; Pain; R | 1986 |
Changes in nociception after acute and chronic administration of zimelidine: different effects in the formalin test and the substance P behavioural assay.
Topics: Animals; Behavior, Animal; Formaldehyde; Male; Mice; Pain; Substance P; Zimeldine | 1987 |
Increased reactivity to chemical but not to heat noxious stimuli in mice producing anti-idiotypic antibodies for substance P.
Topics: Animals; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal; Formaldehyde; Hot Temperature; Immunogl | 1988 |
Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situ.
Topics: Animals; Formaldehyde; Hot Temperature; Male; Pain; Physical Stimulation; Rabbits; Spinal Cord; Subs | 1989 |
Naloxone blocks the formalin-induced increase of substance P in the dorsal horn.
Topics: Animals; Female; Formaldehyde; Immunoenzyme Techniques; Morphine; Naloxone; Pain; Rats; Rats, Inbred | 1989 |
Modified formalin test: characteristic biphasic pain response.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bradykinin; Bromelains; Capsaicin; Dex | 1989 |
Comparison of PD 117302, a kappa agonist, and morphine on colonic transit and formalin-induced pain in rats.
Topics: Animals; Colon; Dose-Response Relationship, Drug; Formaldehyde; Gastrointestinal Transit; Male; Morp | 1989 |
Role of mu and kappa opioid receptors in conditional fear-induced analgesia: the antagonistic actions of nor-binaltorphimine and the cyclic somatostatin octapeptide, Cys2Tyr3Orn5Pen7-amide.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; B | 1989 |
Use of the formalin test in evaluating analgesics.
Topics: Analgesics, Opioid; Animals; Buprenorphine; Butorphanol; Dose-Response Relationship, Drug; Formaldeh | 1989 |
Endogenous GABA released into the fourth ventricle of the rat brain in vivo is enhanced by noxious stimuli.
Topics: Animals; Cerebral Ventricles; Formaldehyde; gamma-Aminobutyric Acid; Glutamates; Glutamic Acid; Male | 1988 |
Peripheral and central antinociceptive actions of ethylketocyclazocine in the formalin test.
Topics: Analgesics; Analgesics, Opioid; Animals; Behavior, Animal; Cyclazocine; Ethylketocyclazocine; Formal | 1988 |
Tonic pain time-dependently affects beta-endorphin-like immunoreactivity in the ventral periaqueductal gray matter of the rat brain.
Topics: Animals; beta-Endorphin; Formaldehyde; Male; Pain; Periaqueductal Gray; Rats; Rats, Inbred Strains; | 1988 |
A dose-ratio comparison of mu and kappa agonists in formalin and thermal pain.
Topics: Analgesia; Animals; Benzomorphans; Cyclazocine; Dose-Response Relationship, Drug; Ethylketocyclazoci | 1986 |
A noxious stimulus induces the preprotachykinin-A gene expression in the rat dorsal root ganglion: a quantitative study using in situ hybridization histochemistry.
Topics: Animals; DNA; Formaldehyde; Ganglia, Spinal; Gene Expression Regulation; Male; Nociceptors; Nucleic | 1988 |
Increase in extracellular potassium level in rat spinal dorsal horn induced by noxious stimulation and peripheral injury.
Topics: Animals; Burns; Burns, Chemical; Evoked Potentials; Female; Formaldehyde; Hot Temperature; Mustard P | 1988 |
Methodological refinements to the mouse paw formalin test. An animal model of tonic pain.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Morphin | 1988 |
Analgesia produced by injection of lidocaine into the lateral hypothalamus.
Topics: Animals; Formaldehyde; Hypothalamus; Injections; Lidocaine; Male; Pain; Pain Measurement; Rats | 1987 |
Involvement of medullary opioid-peptidergic and spinal noradrenergic systems in the regulation of formalin-induced persistent pain.
Topics: Animals; Endorphins; Formaldehyde; Injections, Spinal; Leucine; Male; Medulla Oblongata; Naloxone; N | 1986 |
Effect of neurotropin on hyperalgesia induced by prostaglandin E2, naloxone, melatonin and dark condition in mice.
Topics: Analgesics; Animals; Aspirin; Darkness; Dinoprostone; Formaldehyde; Male; Melatonin; Mice; Naloxone; | 1987 |
Effects of morphine on two types of nucleus raphe dorsalis neurons in awake cats.
Topics: Action Potentials; Animals; Cats; Formaldehyde; Morphine; Naloxone; Neurons; Pain; Raphe Nuclei; Wak | 1987 |
The formalin test in mice: dissociation between inflammatory and non-inflammatory pain.
Topics: Acetaminophen; Analgesics; Animals; Aspirin; Formaldehyde; Male; Mice; Mice, Inbred Strains; Morphin | 1987 |
[Studies of inflammatory pain response: related pain producing substance and endogenous opioid system].
Topics: Analgesics; Animals; Disease Models, Animal; Endorphins; Formaldehyde; Inflammation; Male; Mice; Mic | 1986 |
Prolonged discharge of wide-dynamic-range spinal neurons evoked by formaldehyde injected in their cutaneous receptive fields.
Topics: Animals; Cats; Formaldehyde; Mechanoreceptors; Neurons; Pain; Spinal Cord | 1986 |
The stress of a novel environment reduces formalin pain: possible role of serotonin.
Topics: Animals; Environment; Formaldehyde; Habituation, Psychophysiologic; Methysergide; Naloxone; Pain; Ra | 1986 |
Noncompetitive antagonism of morphine analgesia by diazepam in the formalin test.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Formaldehyde; Male; Morphine; Pain; Rats; React | 1986 |
The effects of some analgesics and neuroleptics upon the reflexive and affective components of the formaldehyde- and bradykinin-induced nociceptive reactions in rats.
Topics: Aminopyrine; Analgesics; Animals; Behavior, Animal; Bradykinin; Chlorpromazine; Dose-Response Relati | 1974 |
Reversal by narcotics and narcotic antagonists of pain-induced functional impairment.
Topics: Analgesics; Animals; Codeine; Dogs; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; | 1973 |
[Relief of pain in the course of endodontic treatment].
Topics: Anesthesia, Dental; Cresols; Dental Pulp Necrosis; Formaldehyde; Pain; Root Canal Therapy; Sulfathia | 1968 |
[On the effect of pain, body exertion, and cold on the neurosecretory system].
Topics: Animals; Cold Temperature; Formaldehyde; Neurosecretion; Pain; Physical Exertion; Rats; Sodium Chlor | 1967 |
Drug reversal of pain induced functional impairment.
Topics: Aminopyrine; Analgesics; Animals; Aspirin; Biological Assay; Codeine; Dextropropoxyphene; Dogs; Elec | 1968 |