fomepizole has been researched along with Retinal Diseases in 3 studies
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Retinal Diseases: Diseases involving the RETINA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methanol poisoning is a hazardous intoxication characterized by visual impairment and formic acidemia." | 1.36 | Ranitidine as an alcohol dehydrogenase inhibitor in acute methanol toxicity in rats. ( Attalla, SM; El-Bakary, AA; El-Dakrory, SA; Hasanein, NA; Malek, HA, 2010) |
| "Methanol metabolism was effectively blocked by fomepizole even after ethanol had been eliminated, and the patient recovered 20/20 vision by day 14 with normal fundoscopy." | 1.31 | Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole. ( Aaron, CK; Brent, J; Burns, MJ; McMartin, KE; Sivilotti, ML, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| El-Bakary, AA | 1 |
| El-Dakrory, SA | 1 |
| Attalla, SM | 1 |
| Hasanein, NA | 1 |
| Malek, HA | 1 |
| Jurgensmeier, C | 1 |
| Bhosale, P | 1 |
| Bernstein, PS | 1 |
| Sivilotti, ML | 1 |
| Burns, MJ | 1 |
| Aaron, CK | 1 |
| McMartin, KE | 1 |
| Brent, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Clinical Interventions Against Stargardt Macular Dystrophy: Phase 1 Pilot Study of 4-MP as an Inhibitor of Dark Adaptation[NCT00346853] | Phase 1 | 10 participants (Actual) | Interventional | 2005-11-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for fomepizole and Retinal Diseases
| Article | Year |
|---|---|
Evaluation of 4-methylpyrazole as a potential therapeutic dark adaptation inhibitor.
Topics: Dark Adaptation; Double-Blind Method; Drug Administration Schedule; Female; Fomepizole; Genes, Reces | 2007 |
2 other studies available for fomepizole and Retinal Diseases
| Article | Year |
|---|---|
Ranitidine as an alcohol dehydrogenase inhibitor in acute methanol toxicity in rats.
Topics: Acidosis; Alcohol Dehydrogenase; Animals; Antidotes; Enzyme Inhibitors; Ethanol; Fomepizole; Formate | 2010 |
Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole.
Topics: Adult; Antidotes; Buffers; Central Nervous System Depressants; Ethanol; Fomepizole; Humans; Male; Me | 2001 |