fomepizole has been researched along with Pregnancy in 11 studies
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The management of methanol poisoning includes early antidote therapy to inhibit the metabolism of methanol to formate." | 7.74 | Methanol poisoning: the duality between 'fast and cheap' and 'slow and expensive'. ( Anseeuw, K; Legrand, A; Sabbe, MB, 2008) |
| "The management of methanol poisoning includes early antidote therapy to inhibit the metabolism of methanol to formate." | 3.74 | Methanol poisoning: the duality between 'fast and cheap' and 'slow and expensive'. ( Anseeuw, K; Legrand, A; Sabbe, MB, 2008) |
| "Fomepizole has been utilized with remarkable success for ethylene glycol and methanol poisonings in children and adults." | 1.38 | Kinetics of fomepizole in pregnant rats. ( Gracia, R; Latimer, B; McMartin, KE, 2012) |
| "Pyrazole or MP did not increase P4502E1 mRNA levels over values for the saline controls." | 1.29 | Induction of liver cytochrome P4502E1 by pyrazole and 4-methylpyrazole in neonatal rats. ( Cederbaum, AI; Wu, D, 1993) |
| "Mouse embryos develop exencephaly when dams are exposed by inhalation to high concentrations (> or = 10,000 ppm) of methanol on gestational day 8 (GD8; copulation plug = GD0)." | 1.29 | Role of formate in methanol-induced exencephaly in CD-1 mice. ( Bolon, B; Dorman, DC; Elswick, B; LaPerle, KM; Struve, MF; Welsch, F; Wong, BA, 1995) |
| "The proximate teratogen of the fetal alcohol syndrome is unknown." | 1.27 | Determination of the proximate teratogen of the mouse fetal alcohol syndrome. 1. Teratogenicity of ethanol and acetaldehyde. ( Blakley, PM; Scott, WJ, 1984) |
| "Acetaldehyde was detectable in maternal blood following all treatments and in maternal liver and embryos following treatment with 7 g/kg ethanol." | 1.27 | Determination of the proximate teratogen of the mouse fetal alcohol syndrome. 2. Pharmacokinetics of the placental transfer of ethanol and acetaldehyde. ( Blakley, PM; Scott, WJ, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gracia, R | 1 |
| Latimer, B | 1 |
| McMartin, KE | 1 |
| Velez, LI | 1 |
| Kulstad, E | 1 |
| Shepherd, G | 1 |
| Roth, B | 1 |
| Anseeuw, K | 1 |
| Sabbe, MB | 1 |
| Legrand, A | 1 |
| Blakley, PM | 2 |
| Scott, WJ | 2 |
| Wu, D | 1 |
| Cederbaum, AI | 1 |
| Dorman, DC | 1 |
| Bolon, B | 1 |
| Struve, MF | 1 |
| LaPerle, KM | 1 |
| Wong, BA | 1 |
| Elswick, B | 1 |
| Welsch, F | 1 |
| Blanchon, L | 1 |
| Sauvant, P | 1 |
| Bavik, C | 1 |
| Gallot, D | 1 |
| Charbonne, F | 1 |
| Alexandre-Gouabau, MC | 1 |
| Lemery, D | 1 |
| Jacquetin, B | 1 |
| Dastugue, B | 1 |
| Ward, S | 1 |
| Sapin, V | 1 |
| Collins, MD | 1 |
| Eckhoff, C | 1 |
| Chahoud, I | 1 |
| Bochert, G | 1 |
| Nau, H | 1 |
| Lau, CF | 1 |
| Vogel, R | 1 |
| Obe, G | 1 |
| Spielmann, H | 1 |
| Simm, B | 1 |
| Murdoch, RN | 1 |
11 other studies available for fomepizole and Pregnancy
| Article | Year |
|---|---|
Kinetics of fomepizole in pregnant rats.
Topics: Animals; Antidotes; Chromatography, High Pressure Liquid; Female; Fetus; Fomepizole; Injections, Int | 2012 |
Inhalational methanol toxicity in pregnancy treated twice with fomepizole.
Topics: Administration, Inhalation; Adult; Antidotes; Diagnosis, Differential; Emergency Treatment; Female; | 2003 |
Methanol poisoning: the duality between 'fast and cheap' and 'slow and expensive'.
Topics: Adult; Antidotes; Belgium; Ethanol; Female; Fomepizole; Hospital Costs; Humans; Inactivation, Metabo | 2008 |
Determination of the proximate teratogen of the mouse fetal alcohol syndrome. 1. Teratogenicity of ethanol and acetaldehyde.
Topics: Abnormalities, Drug-Induced; Acetaldehyde; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; | 1984 |
Determination of the proximate teratogen of the mouse fetal alcohol syndrome. 2. Pharmacokinetics of the placental transfer of ethanol and acetaldehyde.
Topics: Acetaldehyde; Animals; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Fetal Blood; Fomepizole; K | 1984 |
Induction of liver cytochrome P4502E1 by pyrazole and 4-methylpyrazole in neonatal rats.
Topics: Animals; Animals, Newborn; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme System; Dimethylnitrosam | 1993 |
Role of formate in methanol-induced exencephaly in CD-1 mice.
Topics: Animals; Decidua; Embryonic and Fetal Development; Erythrocyte Count; Female; Fomepizole; Formates; | 1995 |
Human choriocarcinoma cell line JEG-3 produces and secretes active retinoids from retinol.
Topics: Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Chloramphenicol O-Acetyltransferase; Choriocarcinoma; | 2002 |
4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse.
Topics: Abnormalities, Drug-Induced; Alcohol Dehydrogenase; Animals; Chromatography, High Pressure Liquid; D | 1992 |
Embryologic and cytogenetic effects of ethanol on preimplantation mouse embryos in vitro.
Topics: Alcohol Dehydrogenase; Animals; Blastocyst; Chromosome Aberrations; Embryo, Mammalian; Embryonic Dev | 1991 |
The role of acetate in alcohol-induced alterations of uterine glucose metabolism in the mouse during pregnancy.
Topics: Acetates; Alcohol Dehydrogenase; Animals; Blood Glucose; Citrates; Ethanol; Female; Fomepizole; Fruc | 1990 |