fomepizole has been researched along with Drug Overdose in 15 studies
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The standard oral or intravenous dosing regimen of NAC is highly effective for patients with moderate overdoses who present within 8 h of APAP ingestion." | 2.82 | Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. ( Akakpo, JY; Curry, SC; Jaeschke, H; Ramachandran, A; Rumack, BH, 2022) |
| "Fomepizole (4-methylpyrazole) is safe and has shown efficacy in preclinical models, human hepatocytes and in volunteers against APAP overdose." | 2.66 | Novel strategies for the treatment of acetaminophen hepatotoxicity. ( Akakpo, JY; Jaeschke, H; Ramachandran, A, 2020) |
| "Fomepizole is a promising new treatment for preventing liver injury following paracetamol (acetaminophen) overdose." | 1.91 | Fomepizole should not be used more liberally in paracetamol overdose. ( Dear, JW, 2023) |
| "Fomepizole has proven safety in methanol and ethylene glycol poisoning and is a potent CYP2E1 and c-Jun-N-terminal Kinase (JNK) inhibitor that is effective even in the metabolic phase." | 1.72 | Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. ( Link, SL; Osmon, S; Rampon, G; Rumack, BH; Scalzo, AJ, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (6.67) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 12 (80.00) | 2.80 |
| Authors | Studies |
|---|---|
| Link, SL | 1 |
| Rampon, G | 1 |
| Osmon, S | 1 |
| Scalzo, AJ | 1 |
| Rumack, BH | 3 |
| Akakpo, JY | 3 |
| Ramachandran, A | 3 |
| Curry, SC | 2 |
| Jaeschke, H | 3 |
| Dear, JW | 3 |
| Filip, AB | 2 |
| Mullins, ME | 3 |
| Shah, KR | 3 |
| Beuhler, MC | 3 |
| Woolum, JA | 1 |
| Hays, WB | 1 |
| Patel, KH | 1 |
| Fox, C | 2 |
| Geib, AJ | 2 |
| Murphy, C | 2 |
| Kopec, K | 2 |
| Kerns Ii, W | 1 |
| Dulaney, A | 2 |
| Bateman, DN | 1 |
| Eddleston, M | 1 |
| Vale, JA | 1 |
| Yeager, LH | 1 |
| Freeman, WE | 1 |
| Kerns, W | 1 |
| Jaeschke, MW | 1 |
| Zakharov, S | 1 |
| Pelclova, D | 1 |
| Urban, P | 1 |
| Navratil, T | 1 |
| Diblik, P | 1 |
| Kuthan, P | 1 |
| Hubacek, JA | 1 |
| Miovsky, M | 1 |
| Klempir, J | 1 |
| Vaneckova, M | 1 |
| Seidl, Z | 1 |
| Pilin, A | 1 |
| Fenclova, Z | 1 |
| Petrik, V | 1 |
| Kotikova, K | 1 |
| Nurieva, O | 1 |
| Ridzon, P | 1 |
| Rulisek, J | 1 |
| Komarc, M | 1 |
| Hovda, KE | 1 |
| Yip, L | 1 |
| Heard, K | 1 |
| Tiamfook-Morgan, TO | 1 |
| Brown, DF | 1 |
| Nadel, ES | 1 |
3 reviews available for fomepizole and Drug Overdose
| Article | Year |
|---|---|
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induc | 2022 |
Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review.
Topics: Acetaminophen; Acetylcysteine; Acidosis; Animals; Antidotes; Cimetidine; Drug Overdose; Edetic Acid; | 2020 |
Novel strategies for the treatment of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Over | 2020 |
12 other studies available for fomepizole and Drug Overdose
| Article | Year |
|---|---|
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fom | 2022 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side | 2023 |
Fomepizole should be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side | 2023 |
Fomepizole should be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side | 2023 |
Fomepizole should be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug-Related Side | 2023 |
Fomepizole as an Adjunctive Treatment in Severe Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2020 |
Use of fomepizole, n-acetylcysteine, and hemodialysis for massive acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Fomepizole; Free | 2020 |
Fomepizole as an adjunctive treatment in severe acetaminophen ingestions: a case series.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Antidotes; Drug Overdose; Drug Thera | 2021 |
Comment on Fomepizole as an adjunctive treatment in severe acetaminophen ingestions.
Topics: Acetaminophen; Antidotes; Drug Overdose; Eating; Fomepizole; Humans | 2021 |
Authors' reply to Comment on Fomepizole as an adjunctive treatment in severe acetaminophen ingestions.
Topics: Acetaminophen; Antidotes; Drug Overdose; Eating; Fomepizole; Humans | 2021 |
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Cell Proliferation; Chemical and Drug Induced Liv | 2021 |
Czech mass methanol outbreak 2012: epidemiology, challenges and clinical features.
Topics: Acidosis; Adolescent; Adult; Aged; Antidotes; Biomarkers; Consciousness; Czech Republic; Disease Out | 2014 |
Potential adjunct treatment for high-risk acetaminophen overdose.
Topics: Acetaminophen; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibi | 2016 |
Change in mental status.
Topics: Acidosis; Adult; Antidotes; Confusion; Depression; Drug Overdose; Ethylene Glycol; Fomepizole; Human | 2007 |