fomepizole has been researched along with Disease Models, Animal in 14 studies
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Liver fibrosis was induced by intraperitoneal injections of carbon tetrachloride (CCl4) or bile duct ligation (BDL) for two weeks." | 1.42 | Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice. ( Choi, HS; Eun, HS; Jeong, WI; Jung, JY; Lee, YS; Park, KG; Park, SH; Suh, JM; Yi, HS, 2015) |
| "Malondialdehyde (MDA) levels were determined in order to assess lipid peroxidation, and caspase-3 activity was determined by immunostaining of liver tissues to evaluate apoptosis." | 1.36 | Effect of lycopene on caspase-3 enzyme activation in liver of methanol-intoxicated rats: comparison with fomepizole. ( Aksoy, N; Atessahin, A; Baba, F; Koksal, M; Kurcer, MA; Kurcer, Z; Ocak, AR; Sahna, E, 2010) |
| "Diazepam was used as a positive control." | 1.35 | Acamprosate attenuates the handling induced convulsions during alcohol withdrawal in Swiss Webster mice. ( Barron, S; Farook, JM; Krazem, A; Lewis, B; Littleton, JM; Morrell, DJ, 2008) |
| "Pretreatment with cyanamide, an inhibitor of aldehyde dehydrogenase, did not attenuate the ethanol-induced decrease in phosphorylation S6k1(Thr(389)), but partially prevented the ethanol-induced lowering of 4EBP1 phosphorylation." | 1.35 | Differential phosphorylation of translation initiation regulators 4EBP1, S6k1, and Erk 1/2 following inhibition of alcohol metabolism in mouse heart. ( Lang, CH; Vary, TC, 2008) |
| "Methanol was administered orally at a dose of 3." | 1.33 | The total antioxidant status in the brain after ethanol or 4-methylpyrazole administration to rats intoxicated with methanol. ( Dudka, J, 2006) |
| " However, ethanol is frequently co-ingested by those who ingest these more toxic alcohols." | 1.32 | Effects of 4-methylpyrazole on ethanol neurobehavioral toxicity in CD-1 mice. ( Maher, T; Páez, AM; Quang, L; Shannon, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (50.00) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Solinski, HJ | 1 |
| Dranchak, P | 1 |
| Oliphant, E | 1 |
| Gu, X | 1 |
| Earnest, TW | 1 |
| Braisted, J | 1 |
| Inglese, J | 1 |
| Hoon, MA | 1 |
| Abrams, RPM | 1 |
| Yasgar, A | 1 |
| Teramoto, T | 1 |
| Lee, MH | 1 |
| Dorjsuren, D | 1 |
| Eastman, RT | 1 |
| Malik, N | 1 |
| Zakharov, AV | 1 |
| Li, W | 1 |
| Bachani, M | 1 |
| Brimacombe, K | 1 |
| Steiner, JP | 1 |
| Hall, MD | 1 |
| Balasubramanian, A | 1 |
| Jadhav, A | 1 |
| Padmanabhan, R | 1 |
| Simeonov, A | 1 |
| Nath, A | 1 |
| Huang, W | 1 |
| Booth, DM | 1 |
| Cane, MC | 1 |
| Chvanov, M | 1 |
| Javed, MA | 1 |
| Elliott, VL | 1 |
| Armstrong, JA | 1 |
| Dingsdale, H | 1 |
| Cash, N | 1 |
| Li, Y | 1 |
| Greenhalf, W | 1 |
| Mukherjee, R | 1 |
| Kaphalia, BS | 1 |
| Jaffar, M | 1 |
| Petersen, OH | 1 |
| Tepikin, AV | 1 |
| Sutton, R | 1 |
| Criddle, DN | 1 |
| Yi, HS | 1 |
| Eun, HS | 1 |
| Lee, YS | 1 |
| Jung, JY | 1 |
| Park, SH | 1 |
| Park, KG | 1 |
| Choi, HS | 1 |
| Suh, JM | 1 |
| Jeong, WI | 1 |
| Farook, JM | 1 |
| Krazem, A | 1 |
| Lewis, B | 1 |
| Morrell, DJ | 1 |
| Littleton, JM | 1 |
| Barron, S | 1 |
| Kurcer, MA | 1 |
| Kurcer, Z | 1 |
| Koksal, M | 1 |
| Baba, F | 1 |
| Ocak, AR | 1 |
| Aksoy, N | 1 |
| Atessahin, A | 1 |
| Sahna, E | 1 |
| Páez, AM | 1 |
| Shannon, M | 1 |
| Maher, T | 1 |
| Quang, L | 1 |
| Sivilotti, ML | 1 |
| Juurlink, DN | 1 |
| Burns, MJ | 1 |
| Ginsburg, BY | 1 |
| Anana, M | 1 |
| Mayorga, O | 1 |
| Hoffman, RS | 1 |
| Dudka, J | 1 |
| Seth, D | 1 |
| Hogg, PJ | 1 |
| Gorrell, MD | 1 |
| McCaughan, GW | 1 |
| Haber, PS | 1 |
| Vary, TC | 1 |
| Lang, CH | 1 |
| Blomstrand, R | 1 |
| Ingemansson, SO | 1 |
| Waller, MB | 1 |
| McBride, WJ | 1 |
| Lumeng, L | 1 |
| Li, TK | 1 |
14 other studies available for fomepizole and Disease Models, Animal
| Article | Year |
|---|---|
Inhibition of natriuretic peptide receptor 1 reduces itch in mice.
Topics: Animals; Behavior, Animal; Cell-Free System; Dermatitis, Contact; Disease Models, Animal; Ganglia, S | 2019 |
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Topics: Animals; Antiviral Agents; Artificial Intelligence; Chlorocebus aethiops; Disease Models, Animal; Dr | 2020 |
Fatty acid ethyl ester synthase inhibition ameliorates ethanol-induced Ca2+-dependent mitochondrial dysfunction and acute pancreatitis.
Topics: Acinar Cells; Acyltransferases; Animals; Apoptosis; Calcium; Calcium Signaling; Carboxylesterase; Ce | 2014 |
Treatment with 4-methylpyrazole modulated stellate cells and natural killer cells and ameliorated liver fibrosis in mice.
Topics: Alcohol Dehydrogenase; Animals; Apoptosis; Bile Ducts; Carbon Tetrachloride; Disease Models, Animal; | 2015 |
Acamprosate attenuates the handling induced convulsions during alcohol withdrawal in Swiss Webster mice.
Topics: Acamprosate; Alcohol Deterrents; Alcohol Withdrawal Seizures; Alcohols; Analysis of Variance; Animal | 2008 |
Effect of lycopene on caspase-3 enzyme activation in liver of methanol-intoxicated rats: comparison with fomepizole.
Topics: Animals; Carotenoids; Caspase 3; Disease Models, Animal; Enzyme Activation; Female; Fomepizole; Huma | 2010 |
Effects of 4-methylpyrazole on ethanol neurobehavioral toxicity in CD-1 mice.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Antidotes; Disease Models, Animal; Dose-Response | 2004 |
Withholding 4-methylpyrazole pretreatment in suspected toxic alcohol ingestions.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Antidotes; Disease Models, Animal; Drug Interact | 2005 |
Withholding 4-methylpyrazole pretreatment in suspected toxic alcohol ingestions.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Antidotes; Disease Models, Animal; Drug Interact | 2005 |
The total antioxidant status in the brain after ethanol or 4-methylpyrazole administration to rats intoxicated with methanol.
Topics: Administration, Inhalation; Administration, Oral; Animals; Antioxidants; Brain; Disease Models, Anim | 2006 |
Direct effects of alcohol on hepatic fibrinolytic balance: implications for alcoholic liver disease.
Topics: Animals; Annexin A2; Antidotes; Biopsy; Cell Line; Central Nervous System Depressants; Disease Model | 2008 |
Differential phosphorylation of translation initiation regulators 4EBP1, S6k1, and Erk 1/2 following inhibition of alcohol metabolism in mouse heart.
Topics: Adaptor Proteins, Signal Transducing; Alcohol Dehydrogenase; Animals; Carrier Proteins; Cell Cycle P | 2008 |
Studies on the effect of 4-methylpyrazole on methanol poisoning using the monkey as an animal model: with particular reference to the ocular toxicity.
Topics: Alcohol Oxidoreductases; Animals; Disease Models, Animal; Disease Susceptibility; Eye; Fomepizole; M | 1984 |
Effects of intravenous ethanol and of 4-methylpyrazole on alcohol drinking in alcohol-preferring rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Disease Models, Animal; Ethanol; Fomepizole; Humans; Male; Py | 1982 |