fomepizole has been researched along with Alcoholism in 14 studies
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Alcoholism: A primary, chronic disease with genetic, psychosocial, and environmental factors influencing its development and manifestations. The disease is often progressive and fatal. It is characterized by impaired control over drinking, preoccupation with the drug alcohol, use of alcohol despite adverse consequences, and distortions in thinking, most notably denial. Each of these symptoms may be continuous or periodic. (Morse & Flavin for the Joint Commission of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism: in JAMA 1992;268:1012-4)
| Excerpt | Relevance | Reference |
|---|---|---|
| "During an outbreak of mass methanol poisoning in the Czech Republic in 2012-2014, we compared the total hospital costs and one-year medical costs in the patients treated with different antidotes (fomepizole versus ethanol) and modalities of hemodialysis (intermittent hemodialysis, IHD, versus continuous renal replacement therapy, CRRT)." | 7.85 | Cost-effectiveness of hospital treatment and outcomes of acute methanol poisoning during the Czech Republic mass poisoning outbreak. ( Balik, M; Belohlavek, J; Pelclova, D; Polak, F; Rulisek, J; Waldauf, P; Zakharov, S, 2017) |
| " In many cases of pediatric ethylene glycol poisoning treated with fomepizole, hemodialysis may not be necessary despite high concentrations and the presence of metabolic acidosis." | 4.86 | Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings. ( Brent, J, 2010) |
| "During an outbreak of mass methanol poisoning in the Czech Republic in 2012-2014, we compared the total hospital costs and one-year medical costs in the patients treated with different antidotes (fomepizole versus ethanol) and modalities of hemodialysis (intermittent hemodialysis, IHD, versus continuous renal replacement therapy, CRRT)." | 3.85 | Cost-effectiveness of hospital treatment and outcomes of acute methanol poisoning during the Czech Republic mass poisoning outbreak. ( Balik, M; Belohlavek, J; Pelclova, D; Polak, F; Rulisek, J; Waldauf, P; Zakharov, S, 2017) |
| "The information on burden of alcohol abuse in Iran is scarce." | 2.53 | A Brief Review on Toxic Alcohols: Management Strategies. ( Hassanian-Moghaddam, H; Zamani, N, 2016) |
| "Chronic alcohol abuse inhibits alcohol dehydrogenase (ADH) and facilitates nonoxidative metabolism of ethanol to fatty acid ethyl esters (FAEEs) in the pancreas frequently damaged during chronic ethanol abuse." | 1.40 | Alcohol oxidizing enzymes and ethanol-induced cytotoxicity in rat pancreatic acinar AR42J cells. ( Ansari, GA; Bhopale, KK; Falzon, M; Kaphalia, BS, 2014) |
| " She received fomepizole at dosing corrected for hemodialysis(HD), and bicarbonate via multiple boluses and continuous infusion." | 1.35 | Head CT in patient with metabolic acidosis. ( Babu, KM; Boyer, EW; Rosenbaum, CD, 2008) |
| "Pyrazole treatment produced an identical 3- to 4-fold increase in content and catalytic activity of P450 2E1 in the two lines." | 1.28 | The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats. ( Cederbaum, AI; Winters, DK, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (21.43) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beauchamp, GA | 1 |
| Valento, M | 1 |
| Kim, J | 1 |
| Kettritz, R | 1 |
| Ritter, T | 1 |
| Rudolph, B | 1 |
| Luft, FC | 1 |
| Bhopale, KK | 1 |
| Falzon, M | 1 |
| Ansari, GA | 1 |
| Kaphalia, BS | 1 |
| Meng, X | 1 |
| Paul, S | 1 |
| Federman, DJ | 1 |
| Himmel, ME | 1 |
| Lam, K | 1 |
| Fralick, M | 1 |
| Hassanian-Moghaddam, H | 1 |
| Zamani, N | 1 |
| Rulisek, J | 1 |
| Balik, M | 1 |
| Polak, F | 1 |
| Waldauf, P | 1 |
| Pelclova, D | 1 |
| Belohlavek, J | 1 |
| Zakharov, S | 1 |
| Babu, KM | 1 |
| Rosenbaum, CD | 1 |
| Boyer, EW | 1 |
| Brent, J | 1 |
| Tuohy, KA | 1 |
| Nicholson, WJ | 1 |
| Schiffman, F | 1 |
| Van Thiel, DH | 1 |
| Waller, MB | 1 |
| McBride, WJ | 1 |
| Lumeng, L | 1 |
| Li, TK | 1 |
| Lindros, KO | 1 |
| Stowell, A | 1 |
| Pikkarainen, P | 1 |
| Salaspuro, M | 1 |
| Winters, DK | 1 |
| Cederbaum, AI | 1 |
3 reviews available for fomepizole and Alcoholism
| Article | Year |
|---|---|
Toxic alcohol ingestion: prompt recognition and management in the emergency department [digest].
Topics: 2-Propanol; Alcoholism; Antidotes; Diagnosis, Differential; Emergency Service, Hospital; Ethanol; Et | 2016 |
A Brief Review on Toxic Alcohols: Management Strategies.
Topics: 2-Propanol; Acidosis; Alcoholism; Antidotes; Ethanol; Ethylene Glycol; Fomepizole; Humans; Iran; Met | 2016 |
Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings.
Topics: Acidosis; Adult; Alcoholism; Antidotes; Bicarbonates; Child; Disease Progression; Ethanol; Ethylene | 2010 |
11 other studies available for fomepizole and Alcoholism
| Article | Year |
|---|---|
The Case | Acid-base diagnoses in the 21st century.
Topics: Acidosis; Acute Kidney Injury; Alcoholic Intoxication; Alcoholism; Antidotes; Creatinine; Ethylene G | 2017 |
Alcohol oxidizing enzymes and ethanol-induced cytotoxicity in rat pancreatic acinar AR42J cells.
Topics: Acinar Cells; Alcohol Dehydrogenase; Alcoholism; Animals; Apoptosis; Ethanol; Fatty Acids; Fomepizol | 2014 |
Metabolic acidosis in a patient with isopropyl alcohol intoxication: a case report.
Topics: 2-Propanol; Acidosis; Alcoholism; Antidotes; Female; Fomepizole; Humans; Middle Aged; Pyrazoles | 2015 |
Hemodialysis in a Healthy Patient--A Case of an Erroneous Laboratory Result: A Teachable Moment.
Topics: Acidosis; Alcoholism; Antidotes; Diagnostic Errors; Female; Fomepizole; Humans; Medical Errors; Meth | 2016 |
Cost-effectiveness of hospital treatment and outcomes of acute methanol poisoning during the Czech Republic mass poisoning outbreak.
Topics: Adult; Alcoholism; Antidotes; Cost-Benefit Analysis; Cross-Sectional Studies; Czech Republic; Diseas | 2017 |
Head CT in patient with metabolic acidosis.
Topics: Acid-Base Imbalance; Acidosis; Adult; Alcoholism; Anisocoria; Antidotes; Bicarbonates; Cerebral Hemo | 2008 |
Agitation by sedation.
Topics: Alcoholism; Antidotes; Chemistry, Pharmaceutical; Ethylene Glycol; Female; Fomepizole; Humans; Hypno | 2003 |
Ethanol: its adverse effects upon the hypothalamic-pituitary-gonadal axis.
Topics: Alcoholism; Animals; Cells, Cultured; Estradiol; Ethanol; Follicle Stimulating Hormone; Fomepizole; | 1983 |
Effects of intravenous ethanol and of 4-methylpyrazole on alcohol drinking in alcohol-preferring rats.
Topics: Alcohol Drinking; Alcoholism; Animals; Disease Models, Animal; Ethanol; Fomepizole; Humans; Male; Py | 1982 |
The disulfiram (Antabuse)-Alcohol reaction in male alcoholics: its efficient management by 4-methylpyrazole.
Topics: Adult; Alcohol Oxidoreductases; Alcoholism; Cyanamide; Disulfiram; Fomepizole; Humans; Male; Pyrazol | 1981 |
The content and activity of cytochrome P450 2E1 in liver microsomes from alcohol-preferring and non-preferring rats.
Topics: Alcoholism; Animals; Cytochrome P-450 Enzyme System; Enzyme Induction; Fomepizole; Immunoblotting; M | 1992 |