fomepizole has been researched along with Acute Liver Injury, Drug-Induced in 22 studies
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fomepizole has been linked to few adverse effects." | 2.82 | Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review. ( Mehrpour, O; Nakhaee, S; Pourbagher-Shahri, AM; Schimmel, J; Shirazi, FM, 2022) |
| " The standard oral or intravenous dosing regimen of NAC is highly effective for patients with moderate overdoses who present within 8 h of APAP ingestion." | 2.82 | Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. ( Akakpo, JY; Curry, SC; Jaeschke, H; Ramachandran, A; Rumack, BH, 2022) |
| "Fomepizole (4-methylpyrazole) is safe and has shown efficacy in preclinical models, human hepatocytes and in volunteers against APAP overdose." | 2.66 | Novel strategies for the treatment of acetaminophen hepatotoxicity. ( Akakpo, JY; Jaeschke, H; Ramachandran, A, 2020) |
| "Fomepizole is a promising new treatment for preventing liver injury following paracetamol (acetaminophen) overdose." | 1.91 | Fomepizole should not be used more liberally in paracetamol overdose. ( Dear, JW, 2023) |
| "Fomepizole has proven safety in methanol and ethylene glycol poisoning and is a potent CYP2E1 and c-Jun-N-terminal Kinase (JNK) inhibitor that is effective even in the metabolic phase." | 1.72 | Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series. ( Link, SL; Osmon, S; Rampon, G; Rumack, BH; Scalzo, AJ, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (9.09) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 9 (40.91) | 24.3611 |
| 2020's | 10 (45.45) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Liu, Z | 1 |
| Shi, Q | 1 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Fang, H | 1 |
| Tong, W | 2 |
| Chen, M | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Link, SL | 1 |
| Rampon, G | 1 |
| Osmon, S | 1 |
| Scalzo, AJ | 1 |
| Rumack, BH | 6 |
| Pourbagher-Shahri, AM | 1 |
| Schimmel, J | 1 |
| Shirazi, FM | 1 |
| Nakhaee, S | 1 |
| Mehrpour, O | 1 |
| Akakpo, JY | 7 |
| Ramachandran, A | 7 |
| Curry, SC | 3 |
| Jaeschke, H | 7 |
| Filip, AB | 1 |
| Berg, SE | 1 |
| Mullins, ME | 1 |
| Schwarz, ES | 1 |
| Jaeschke, MW | 3 |
| Etemadi, Y | 1 |
| Artigues, A | 1 |
| Toerber, S | 1 |
| Olivos, H | 1 |
| Shrestha, B | 1 |
| Midey, A | 1 |
| Dear, JW | 2 |
| Shah, KR | 1 |
| Beuhler, MC | 1 |
| Orhan, H | 1 |
| Kandel, SE | 1 |
| Ni, HM | 1 |
| Kumer, SC | 1 |
| Nanagas, K | 1 |
| Avera, R | 1 |
| Purpura, A | 1 |
| Murphy, J | 1 |
| Kao, L | 1 |
| Duan, L | 1 |
| Schaich, MA | 1 |
| Freudenthal, BD | 1 |
| Ding, WX | 1 |
| Holownia, A | 1 |
| Mroz, RM | 1 |
| Wielgat, P | 1 |
| Jakubow, P | 1 |
| Jablonski, J | 1 |
| Sulek, J | 1 |
| Braszko, JJ | 1 |
| Lee, YS | 1 |
| Yi, HS | 1 |
| Suh, YG | 1 |
| Byun, JS | 1 |
| Eun, HS | 1 |
| Kim, SY | 1 |
| Seo, W | 1 |
| Jeong, JM | 1 |
| Choi, WM | 1 |
| Kim, MH | 1 |
| Kim, JH | 1 |
| Park, KG | 1 |
| Jeong, WI | 1 |
| Yip, L | 1 |
| Heard, K | 1 |
| Wu, D | 1 |
| Cederbaum, AI | 1 |
| Karas, M | 1 |
| Chakrabarti, SK | 1 |
| Burk, RF | 1 |
| Hill, KE | 1 |
| Hunt, RW | 1 |
| Martin, AE | 1 |
4 reviews available for fomepizole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Use of fomepizole (4-methylpyrazole) for acetaminophen poisoning: A scoping review.
Topics: Acetaminophen; Antidotes; Chemical and Drug Induced Liver Injury; Fomepizole; Humans | 2022 |
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Animals; Antidotes; Chemical and Drug Induc | 2022 |
Novel strategies for the treatment of acetaminophen hepatotoxicity.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Over | 2020 |
18 other studies available for fomepizole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Fomepizole as an adjunct in acetylcysteine treated acetaminophen overdose patients: a case series.
Topics: Acetaminophen; Acetylcysteine; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Fom | 2022 |
Fomepizole as an adjunctive therapy for acetaminophen poisoning: cases reported to the toxicology investigators consortium (ToxIC) database 2015-2020.
Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Databases, Factual; Fomepizol | 2022 |
Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Humans; Liver; Mice; Mic | 2022 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole should not be used more liberally in paracetamol overdose.
Topics: Acetaminophen; Acetylcysteine; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Injury; COV | 2023 |
Fomepizole as an Adjunctive Treatment in Severe Acetaminophen Toxicity.
Topics: Acetaminophen; Acetylcysteine; Adult; Analgesics, Non-Narcotic; Chemical and Drug Induced Liver Inju | 2020 |
4-methylpyrazole protects against acetaminophen-induced acute kidney injury.
Topics: Acetaminophen; Acute Kidney Injury; Adolescent; Adult; Aged; Animals; Chemical and Drug Induced Live | 2020 |
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole.
Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Cell Proliferation; Chemical and Drug Induced Liv | 2021 |
4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes.
Topics: Acetaminophen; Animals; Cells, Cultured; Chemical and Drug Induced Liver Injury; Fomepizole; Glutath | 2018 |
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Topics: Alcohol Withdrawal Delirium; Antidotes; Carbon Monoxide Poisoning; Chemical and Drug Induced Liver I | 2018 |
Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; JNK Mitogen-Activated Pr | 2019 |
Histone acetylation and arachidonic acid cytotoxicity in HepG2 cells overexpressing CYP2E1.
Topics: Acetates; Acetylation; Antioxidants; Arachidonic Acid; Chemical and Drug Induced Liver Injury; Cytoc | 2014 |
Blockade of Retinol Metabolism Protects T Cell-Induced Hepatitis by Increasing Migration of Regulatory T Cells.
Topics: Alcohol Dehydrogenase; Animals; Cell Differentiation; Cell Movement; Cell Survival; Chemical and Dru | 2015 |
Potential adjunct treatment for high-risk acetaminophen overdose.
Topics: Acetaminophen; Benzoquinones; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibi | 2016 |
Combined effects of streptozotocin-induced diabetes plus 4-methylpyrazole treatment on rat liver cytochrome P4502E1.
Topics: Animals; Carbon Tetrachloride; Catalysis; Chemical and Drug Induced Liver Injury; Cytochrome P-450 C | 1993 |
Influence of caffeine on allyl alcohol-induced hepatotoxicity in rats. I. In vivo study.
Topics: Acrolein; Alanine Transaminase; Alcohol Dehydrogenase; Animals; Caffeine; Chemical and Drug Induced | 2001 |
Isoniazid potentiation of acetaminophen hepatotoxicity in the rat and 4-methylpyrazole inhibition of it.
Topics: Acetaminophen; Alanine Transaminase; Animals; Chemical and Drug Induced Liver Injury; Fomepizole; Gl | 1990 |