Page last updated: 2024-10-27

fomepizole and Acidosis

fomepizole has been researched along with Acidosis in 46 studies

Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.

Acidosis: A pathologic condition of acid accumulation or depletion of base in the body. The two main types are RESPIRATORY ACIDOSIS and metabolic acidosis, due to metabolic acid build up.

Research Excerpts

ExcerptRelevanceReference
"Ethylene glycol is metabolized to toxic metabolites that cause acute kidney injury, metabolic acidemia, and death."9.22Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review. ( Beaulieu, J; Ghannoum, M; Gosselin, S; Hoffman, RS; Hovda, KE; Lavergne, V; Lung, D; Megarbane, B; Roberts, DM; Thanacoody, R, 2022)
"Fomepizole appears to be safe and effective in the treatment of methanol poisoning."9.09Fomepizole for the treatment of methanol poisoning. ( Aaron, C; Brent, J; Kulig, K; McMartin, K; Phillips, S, 2001)
"Fomepizole is now the antidote of choice in methanol poisoning."8.84Expert opinion: fomepizole may ameliorate the need for hemodialysis in methanol poisoning. ( Hovda, KE; Jacobsen, D, 2008)
"Ingestion of ethylene glycol may be an important contributor in patients with metabolic acidosis of unknown cause and subsequent renal failure."8.81Treatment of ethylene glycol poisoning. ( Archie, TE; Ferguson, DR; Piccaro, JC; Scalley, RD; Smart, ML, 2002)
"Ethylene glycol (EG) toxicity is an important cause of toxic alcohol poisoning in the USA with over 5,000 exposures reported annually."8.31Mass Poisoning From Ethylene Glycol at a U.S. Military Base. ( Banda, M; Forster, BM; Khayat, M; King, JD; Munoz, J; Owshalimpur, D; Petteys, SK; Shah, N; Sullivan, SB; Watson, M; White, WC, 2023)
"We present an unusual case of a coingestion of ethanol and 150-250 mL of pure 2BE, which resulted in rapid obtundation, severe airway edema, hypotension, and prolonged acidosis despite the coingestion of ethanol and the administration of a loading dose of fomepizole."7.76Fomepizole fails to prevent progression of acidosis in 2-butoxyethanol and ethanol coingestion. ( Dewitt, CR; Holmes, DT; Hung, T; Martz, W; Schreiber, W, 2010)
"Fomepizole may precipitate bradycardia and/or hypotension during hemodialysis."7.74Bradycardia and hypotension associated with fomepizole infusion during hemodialysis. ( Brignall, JL; Brubacher, JR; DeWitt, CR; Erhardt, GD; Kennedy, JR; Lam, GS; Lawson, EJ; Lepik, KJ; Purssell, RA, 2008)
"Ethylene glycol is a toxic alcohol which may induce significant toxicity when ingested accidentally or intentionally."6.72The three biological gaps and hyperoxaluria in ethylene glycol poisoning: case presentation and review. ( Ahmad, Y; Chiche, JD; Kissling, S; Liaudet, L; Ltaief, Z; Torrent, C, 2021)
"Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste."6.45Diethylene glycol poisoning. ( Beasley, DM; Schep, LJ; Slaughter, RJ; Temple, WA, 2009)
"Ethylene glycol intoxication is a rare but dangerous type of poisoning."6.40Diagnosis and treatment of an unusual cause of metabolic acidosis: ethylene glycol poisoning. ( Lejeune, P; Piagnerelli, M; Vanhaeverbeek, M, 1999)
"Methanol intoxication was suspected due to high anion gap metabolic acidosis (pH, 6."5.43A Rare Cause of Metabolic Acidosis: Fatal Transdermal Methanol Intoxication in an Infant. ( Aksu, N; Anil, AB; Anil, M; Bal, A; Can, FK; Gokalp, G; Sahbudak Bal, Z; Yavascan, O, 2016)
"Ethylene glycol is metabolized to toxic metabolites that cause acute kidney injury, metabolic acidemia, and death."5.22Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review. ( Beaulieu, J; Ghannoum, M; Gosselin, S; Hoffman, RS; Hovda, KE; Lavergne, V; Lung, D; Megarbane, B; Roberts, DM; Thanacoody, R, 2022)
"Fomepizole appears to be safe and effective in the treatment of methanol poisoning."5.09Fomepizole for the treatment of methanol poisoning. ( Aaron, C; Brent, J; Kulig, K; McMartin, K; Phillips, S, 2001)
"I searched MEDLINE for articles published between 1969 and 2014 using the terms: toxic alcohols, serum osmolality, serum osmol gap, serum anion gap, metabolic acidosis, methanol, ethylene glycol, diethylene glycol, propylene glycol, and fomepizole."4.91Diagnosis of toxic alcohols: limitations of present methods. ( Kraut, JA, 2015)
" In many cases of pediatric ethylene glycol poisoning treated with fomepizole, hemodialysis may not be necessary despite high concentrations and the presence of metabolic acidosis."4.86Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings. ( Brent, J, 2010)
"Fomepizole is now the antidote of choice in methanol poisoning."4.84Expert opinion: fomepizole may ameliorate the need for hemodialysis in methanol poisoning. ( Hovda, KE; Jacobsen, D, 2008)
"Acute methanol poisoning is mainly the consequence of voluntary or accidental ingestion."4.83[Acute methanol intoxication: physiopathology, prognosis and treatment]. ( Hantson, PE, 2006)
"Ingestion of ethylene glycol may be an important contributor in patients with metabolic acidosis of unknown cause and subsequent renal failure."4.81Treatment of ethylene glycol poisoning. ( Archie, TE; Ferguson, DR; Piccaro, JC; Scalley, RD; Smart, ML, 2002)
"Ethylene glycol (EG) toxicity is an important cause of toxic alcohol poisoning in the USA with over 5,000 exposures reported annually."4.31Mass Poisoning From Ethylene Glycol at a U.S. Military Base. ( Banda, M; Forster, BM; Khayat, M; King, JD; Munoz, J; Owshalimpur, D; Petteys, SK; Shah, N; Sullivan, SB; Watson, M; White, WC, 2023)
"Ethylene glycol toxicity is a known cause of anion gap metabolic acidosis, with the presence of an osmolar gap and the right clinical context suggesting to the diagnosis."3.88Lactate gap as a tool in identifying ethylene glycol poisoning. ( Jimenez, CA; Mckelvy, BJ; Sagar, AS, 2018)
"02; (2) 2 Na-dependent acid extruders and a Cl-dependent acid loading carrier exist and are functional; (3) alcohol functions in a concentration-dependent manner to reduce pHi and increase NHE activity, but it does not affect CHE activity; and (4) fomepizole, a specific alcohol dehydrogenase inhibitor, does not change the intracellular acidosis and NHE activity-induced by alcohol, whereas 3-amino-1, 2,4-trizole, a specific catalase inhibitor, entirely abolishes these effects."3.77Functional characterization of transmembrane intracellular pH regulators and mechanism of alcohol-induced intracellular acidosis in human umbilical cord blood stem cell-like cells. ( Chen, MH; Chen, WH; Lee, CY; Liu, JY; Loh, SH; Ou, CC; Tsai, CS; Tsai, YT, 2011)
"We present an unusual case of a coingestion of ethanol and 150-250 mL of pure 2BE, which resulted in rapid obtundation, severe airway edema, hypotension, and prolonged acidosis despite the coingestion of ethanol and the administration of a loading dose of fomepizole."3.76Fomepizole fails to prevent progression of acidosis in 2-butoxyethanol and ethanol coingestion. ( Dewitt, CR; Holmes, DT; Hung, T; Martz, W; Schreiber, W, 2010)
"Fomepizole may precipitate bradycardia and/or hypotension during hemodialysis."3.74Bradycardia and hypotension associated with fomepizole infusion during hemodialysis. ( Brignall, JL; Brubacher, JR; DeWitt, CR; Erhardt, GD; Kennedy, JR; Lam, GS; Lawson, EJ; Lepik, KJ; Purssell, RA, 2008)
"Based on our data, methanol-poisoned patients with moderate metabolic acidosis and methanol levels up to 19 mmol/L (60 mg/L) may safely be treated with bicarbonate and fomepizole only, without dialysis."3.73Methanol and formate kinetics during treatment with fomepizole. ( Andersson, KS; Hovda, KE; Jacobsen, D; Urdal, P, 2005)
"Ethylene glycol is a toxic alcohol which may induce significant toxicity when ingested accidentally or intentionally."2.72The three biological gaps and hyperoxaluria in ethylene glycol poisoning: case presentation and review. ( Ahmad, Y; Chiche, JD; Kissling, S; Liaudet, L; Ltaief, Z; Torrent, C, 2021)
"The information on burden of alcohol abuse in Iran is scarce."2.53A Brief Review on Toxic Alcohols: Management Strategies. ( Hassanian-Moghaddam, H; Zamani, N, 2016)
"Fomepizole has few side effects and is easy to use in practice and it may obviate the need for haemodialysis in some, but not all, patients."2.53Antidotes for poisoning by alcohols that form toxic metabolites. ( Hovda, KE; Jacobsen, D; McMartin, K, 2016)
"Diethylene glycol (DEG) is a clear, colorless, practically odorless, viscous, hygroscopic liquid with a sweetish taste."2.45Diethylene glycol poisoning. ( Beasley, DM; Schep, LJ; Slaughter, RJ; Temple, WA, 2009)
"Ethylene glycol intoxication is a rare but dangerous type of poisoning."2.40Diagnosis and treatment of an unusual cause of metabolic acidosis: ethylene glycol poisoning. ( Lejeune, P; Piagnerelli, M; Vanhaeverbeek, M, 1999)
"Diethylene glycol (DEG) is an industrial solvent with many uses, including brake fluids."1.72Symptomatic Diethylene Glycol Ingestion Successfully Treated with Fomepizole Monotherapy. ( Clark, RF; Corbett, B; Lasoff, DR; Seltzer, JA, 2022)
"Methanol intoxication was suspected due to high anion gap metabolic acidosis (pH, 6."1.43A Rare Cause of Metabolic Acidosis: Fatal Transdermal Methanol Intoxication in an Infant. ( Aksu, N; Anil, AB; Anil, M; Bal, A; Can, FK; Gokalp, G; Sahbudak Bal, Z; Yavascan, O, 2016)
" Although these studies suggest that either metabolite may be involved in producing kidney toxicity, the unexpected renal accumulation of DGA at toxic doses of DEG suggests that it must also be considered a possible toxic metabolite of DEG."1.37Role of tissue metabolite accumulation in the renal toxicity of diethylene glycol. ( Bartels, M; Besenhofer, LM; Filary, MJ; Latimer, B; McLaren, MC; McMartin, KE; Perala, AW, 2011)
"Methanol poisoning is a hazardous intoxication characterized by visual impairment and formic acidemia."1.36Ranitidine as an alcohol dehydrogenase inhibitor in acute methanol toxicity in rats. ( Attalla, SM; El-Bakary, AA; El-Dakrory, SA; Hasanein, NA; Malek, HA, 2010)
" She received fomepizole at dosing corrected for hemodialysis(HD), and bicarbonate via multiple boluses and continuous infusion."1.35Head CT in patient with metabolic acidosis. ( Babu, KM; Boyer, EW; Rosenbaum, CD, 2008)
"Treatment of methanol poisoning includes administration of buffer, antidote and hemodialysis."1.33Fomepizole may change indication for hemodialysis in methanol poisoning: prospective study in seven cases. ( Froyshov, S; Gudmundsdottir, H; Hovda, KE; Jacobsen, D; Rudberg, N, 2005)
"Ethylene glycol is an inexpensive, readily available substance that may be associated with accidental or intentional toxicity."1.32Ethylene glycol toxicity. ( Cox, RD; Phillips, WJ, 2004)
"The fomepizole treatment protocol (10 mg/kg by i."1.30Fomepizole (4-methylpyrazole) in fatal methanol poisoning with early CT scan cerebral lesions. ( Bonmarchand, G; Callonnec, F; Droy, JM; Girault, C; Leroy, J; Moritz, F; Tamion, F, 1999)

Research

Studies (46)

TimeframeStudies, this research(%)All Research%
pre-19901 (2.17)18.7374
1990's2 (4.35)18.2507
2000's18 (39.13)29.6817
2010's18 (39.13)24.3611
2020's7 (15.22)2.80

Authors

AuthorsStudies
Ahmad, Y1
Kissling, S1
Torrent, C1
Chiche, JD1
Liaudet, L1
Ltaief, Z1
Beaulieu, J1
Roberts, DM1
Gosselin, S1
Hoffman, RS1
Lavergne, V1
Hovda, KE6
Megarbane, B1
Lung, D1
Thanacoody, R1
Ghannoum, M1
Seltzer, JA1
Corbett, B1
Lasoff, DR1
Clark, RF1
Shah, N1
Khayat, M1
Owshalimpur, D1
Banda, M1
Munoz, J1
White, WC1
Forster, BM1
Petteys, SK1
Sullivan, SB1
Watson, M1
King, JD1
Inman, B1
Maddry, JK1
Ng, PC1
Koyfman, A1
Long, B1
Cervantes, CE1
Chu, A1
Heller, D1
Lemont, M1
Mullins, ME1
Yeager, LH1
Freeman, WE1
Kettritz, R1
Ritter, T1
Rudolph, B1
Luft, FC1
Sagar, AS1
Jimenez, CA1
Mckelvy, BJ1
Zakharov, S1
Pelclova, D1
Urban, P1
Navratil, T1
Diblik, P1
Kuthan, P1
Hubacek, JA1
Miovsky, M1
Klempir, J1
Vaneckova, M1
Seidl, Z1
Pilin, A1
Fenclova, Z1
Petrik, V1
Kotikova, K1
Nurieva, O1
Ridzon, P1
Rulisek, J1
Komarc, M1
Meng, X1
Paul, S1
Federman, DJ1
Kraut, JA2
Sahbudak Bal, Z1
Can, FK1
Anil, AB1
Bal, A1
Anil, M1
Gokalp, G1
Yavascan, O1
Aksu, N1
McMartin, K2
Jacobsen, D4
Schoen, JC1
Cain, MR1
Robinson, JA1
Schiltz, BM1
Mannenbach, MS1
Himmel, ME1
Lam, K1
Fralick, M1
Maiti, A1
Das, A1
Hassanian-Moghaddam, H1
Zamani, N1
Collister, D1
Duff, G1
Palatnick, W1
Komenda, P1
Tangri, N1
Hingwala, J1
Lepik, KJ1
Brubacher, JR1
DeWitt, CR2
Lam, GS1
Lawson, EJ1
Erhardt, GD1
Purssell, RA1
Kennedy, JR1
Brignall, JL1
Rastogi, A1
Itagaki, B1
Bajwa, M1
Wallace, EA1
Green, AS1
Babu, KM1
Rosenbaum, CD1
Boyer, EW1
Brent, J3
Schep, LJ1
Slaughter, RJ1
Temple, WA1
Beasley, DM1
El-Bakary, AA1
El-Dakrory, SA1
Attalla, SM1
Hasanein, NA1
Malek, HA1
Hung, T1
Martz, W1
Schreiber, W1
Holmes, DT1
Besenhofer, LM1
McLaren, MC1
Latimer, B1
Bartels, M1
Filary, MJ1
Perala, AW1
McMartin, KE1
Tsai, YT1
Liu, JY1
Lee, CY1
Tsai, CS1
Chen, MH1
Ou, CC1
Chen, WH1
Loh, SH1
Lapatto-Reiniluoto, O1
Ikäheimo, R1
Scalley, RD1
Ferguson, DR1
Piccaro, JC1
Smart, ML1
Archie, TE1
Osterhoudt, KC1
Kostic, MA1
Dart, RC1
Caravati, EM1
Heileson, HL1
Jones, M1
Cox, RD1
Phillips, WJ1
LoVecchio, F1
Sawyers, B1
Thole, D1
Beuler, MC1
Winchell, J1
Curry, SC1
Andersson, KS1
Urdal, P1
Froyshov, S1
Gudmundsdottir, H1
Rudberg, N1
Hantson, PE1
Tiamfook-Morgan, TO1
Brown, DF1
Nadel, ES1
Girault, C1
Tamion, F1
Moritz, F1
Callonnec, F1
Droy, JM1
Bonmarchand, G1
Leroy, J1
Piagnerelli, M1
Lejeune, P1
Vanhaeverbeek, M1
Phillips, S1
Aaron, C1
Kulig, K1
Jeganathan, PS1
Namasivayam, A1

Reviews

16 reviews available for fomepizole and Acidosis

ArticleYear
The three biological gaps and hyperoxaluria in ethylene glycol poisoning: case presentation and review.
    European review for medical and pharmacological sciences, 2021, Volume: 25, Issue:20

    Topics: Acidosis; Antidotes; Delayed Diagnosis; Ethylene Glycol; Female; Fomepizole; Humans; Hyperoxaluria;

2021
Treating ethylene glycol poisoning with alcohol dehydrogenase inhibition, but without extracorporeal treatments: a systematic review.
    Clinical toxicology (Philadelphia, Pa.), 2022, Volume: 60, Issue:7

    Topics: Acidosis; Acute Kidney Injury; Alcohol Dehydrogenase; Antidotes; Ethanol; Ethylene Glycol; Fomepizol

2022
High risk and low prevalence diseases: Toxic alcohol ingestion.
    The American journal of emergency medicine, 2023, Volume: 67

    Topics: Acidosis; Eating; Ethanol; Fomepizole; Humans; Methanol; Prevalence

2023
Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review.
    Clinical toxicology (Philadelphia, Pa.), 2020, Volume: 58, Issue:12

    Topics: Acetaminophen; Acetylcysteine; Acidosis; Animals; Antidotes; Cimetidine; Drug Overdose; Edetic Acid;

2020
Diagnosis of toxic alcohols: limitations of present methods.
    Clinical toxicology (Philadelphia, Pa.), 2015, Volume: 53, Issue:7

    Topics: Acid-Base Equilibrium; Acidosis; Alcohols; Ethylene Glycol; Ethylene Glycols; Fomepizole; Humans; Me

2015
Antidotes for poisoning by alcohols that form toxic metabolites.
    British journal of clinical pharmacology, 2016, Volume: 81, Issue:3

    Topics: Acidosis; Antidotes; Ethanol; Ethylene Glycol; Ethylene Glycols; Fomepizole; Humans; Methanol; Pyraz

2016
A Brief Review on Toxic Alcohols: Management Strategies.
    Iranian journal of kidney diseases, 2016, Volume: 10, Issue:6

    Topics: 2-Propanol; Acidosis; Alcoholism; Antidotes; Ethanol; Ethylene Glycol; Fomepizole; Humans; Iran; Met

2016
Expert opinion: fomepizole may ameliorate the need for hemodialysis in methanol poisoning.
    Human & experimental toxicology, 2008, Volume: 27, Issue:7

    Topics: Acidosis; Antidotes; Bicarbonates; Drug Therapy, Combination; Fomepizole; Humans; Methanol; Poisonin

2008
Fomepizole for ethylene glycol and methanol poisoning.
    The New England journal of medicine, 2009, May-21, Volume: 360, Issue:21

    Topics: Acidosis; Adult; Antidotes; Blood Chemical Analysis; Ethylene Glycol; Fomepizole; Humans; Male; Meth

2009
Diethylene glycol poisoning.
    Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:6

    Topics: Acidosis; Animals; Antidotes; Drug Contamination; Environmental Exposure; Ethanol; Ethylene Glycols;

2009
Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings.
    Clinical toxicology (Philadelphia, Pa.), 2010, Volume: 48, Issue:5

    Topics: Acidosis; Adult; Alcoholism; Antidotes; Bicarbonates; Child; Disease Progression; Ethanol; Ethylene

2010
[Surrogate alcohol poisonings].
    Duodecim; laaketieteellinen aikakauskirja, 2012, Volume: 128, Issue:20

    Topics: Acidosis; Antidotes; Ethylene Glycol; Finland; Fomepizole; Humans; Methanol; Poisoning; Pyrazoles; R

2012
Treatment of ethylene glycol poisoning.
    American family physician, 2002, Sep-01, Volume: 66, Issue:5

    Topics: Acidosis; Acute Kidney Injury; Adult; Antidotes; Ethylene Glycol; Fomepizole; Humans; Male; Osmolar

2002
Rethinking the toxic methanol level.
    Journal of toxicology. Clinical toxicology, 2003, Volume: 41, Issue:6

    Topics: Acidosis; Adolescent; Adult; Antidotes; Bicarbonates; Child, Preschool; Dose-Response Relationship,

2003
[Acute methanol intoxication: physiopathology, prognosis and treatment].
    Bulletin et memoires de l'Academie royale de medecine de Belgique, 2006, Volume: 161, Issue:6

    Topics: Acidosis; Acute Disease; Antidotes; Central Nervous System; Fomepizole; Formaldehyde; Humans; Liver;

2006
Diagnosis and treatment of an unusual cause of metabolic acidosis: ethylene glycol poisoning.
    Acta clinica Belgica, 1999, Volume: 54, Issue:6

    Topics: Acid-Base Imbalance; Acidosis; Alcohol Dehydrogenase; Antidotes; Bone Marrow Diseases; Enzyme Inhibi

1999

Trials

1 trial available for fomepizole and Acidosis

ArticleYear
Fomepizole for the treatment of methanol poisoning.
    The New England journal of medicine, 2001, Feb-08, Volume: 344, Issue:6

    Topics: Acidosis; Adolescent; Adult; Alcohol Dehydrogenase; Antidotes; Enzyme Inhibitors; Female; Fomepizole

2001

Other Studies

29 other studies available for fomepizole and Acidosis

ArticleYear
Symptomatic Diethylene Glycol Ingestion Successfully Treated with Fomepizole Monotherapy.
    The Journal of emergency medicine, 2022, Volume: 63, Issue:1

    Topics: Acidosis; Adult; Alcohol Dehydrogenase; Aldehyde Dehydrogenase; Antidotes; Eating; Ethylene Glycol;

2022
Mass Poisoning From Ethylene Glycol at a U.S. Military Base.
    Military medicine, 2023, 08-29, Volume: 188, Issue:9-10

    Topics: Acidosis; Ethylene Glycol; Fomepizole; Humans; Military Facilities; Poisoning; Renal Dialysis

2023
Early dialysis in a rare case of combined toxic alcohols ingestion.
    CEN case reports, 2020, Volume: 9, Issue:1

    Topics: Acidosis; Adult; Alcohols; Antidotes; Bicarbonates; Buffers; Combined Modality Therapy; Eating; Ethy

2020
The Case | Acid-base diagnoses in the 21st century.
    Kidney international, 2017, Volume: 92, Issue:5

    Topics: Acidosis; Acute Kidney Injury; Alcoholic Intoxication; Alcoholism; Antidotes; Creatinine; Ethylene G

2017
Lactate gap as a tool in identifying ethylene glycol poisoning.
    BMJ case reports, 2018, Mar-09, Volume: 2018

    Topics: Acidosis; Antidotes; Diagnosis, Differential; Dialysis; Ethylene Glycol; Fomepizole; Humans; Lactic

2018
Czech mass methanol outbreak 2012: epidemiology, challenges and clinical features.
    Clinical toxicology (Philadelphia, Pa.), 2014, Volume: 52, Issue:10

    Topics: Acidosis; Adolescent; Adult; Aged; Antidotes; Biomarkers; Consciousness; Czech Republic; Disease Out

2014
Metabolic acidosis in a patient with isopropyl alcohol intoxication: a case report.
    Annals of internal medicine, 2015, Feb-17, Volume: 162, Issue:4

    Topics: 2-Propanol; Acidosis; Alcoholism; Antidotes; Female; Fomepizole; Humans; Middle Aged; Pyrazoles

2015
A Rare Cause of Metabolic Acidosis: Fatal Transdermal Methanol Intoxication in an Infant.
    Pediatric emergency care, 2016, Volume: 32, Issue:8

    Topics: Acidosis; Antidotes; Fatal Outcome; Female; Fomepizole; Humans; Infant; Methanol; Pyrazoles; Renal D

2016
Adolescent Presents With Altered Mental Status and Elevated Anion Gap After Suicide Attempt by Ethylene Glycol Ingestion.
    Pediatric emergency care, 2016, Volume: 32, Issue:10

    Topics: Acidosis; Adolescent; Depressive Disorder, Major; Diagnosis, Differential; Ethylene Glycol; Fomepizo

2016
Hemodialysis in a Healthy Patient--A Case of an Erroneous Laboratory Result: A Teachable Moment.
    JAMA internal medicine, 2016, Volume: 176, Issue:4

    Topics: Acidosis; Alcoholism; Antidotes; Diagnostic Errors; Female; Fomepizole; Humans; Medical Errors; Meth

2016
A man with altered mental status and metabolic acidosis.
    BMJ (Clinical research ed.), 2016, 04-28, Volume: 353

    Topics: Acid-Base Equilibrium; Acidosis; Antidotes; Confusion; Dyspnea; Ethylene Glycol; Fomepizole; Hematur

2016
A Methanol Intoxication Outbreak From Recreational Ingestion of Fracking Fluid.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2017, Volume: 69, Issue:5

    Topics: Acid-Base Equilibrium; Acidosis; Adult; Antidotes; Disease Outbreaks; Eating; Fomepizole; Humans; Hy

2017
Bradycardia and hypotension associated with fomepizole infusion during hemodialysis.
    Clinical toxicology (Philadelphia, Pa.), 2008, Volume: 46, Issue:6

    Topics: Acidosis; Antidotes; Blood Pressure; Bradycardia; Dose-Response Relationship, Drug; Ethylene Glycol;

2008
Spurious elevation in serum creatinine caused by ingestion of nitromethane: implication for the diagnosis and treatment of methanol intoxication.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2008, Volume: 52, Issue:1

    Topics: Acidosis; Acute Kidney Injury; Adult; Creatinine; Female; Follow-Up Studies; Fomepizole; Humans; Kid

2008
Methanol toxicity secondary to inhalant abuse in adult men.
    Clinical toxicology (Philadelphia, Pa.), 2009, Volume: 47, Issue:3

    Topics: Acidosis; Adult; Antidotes; Ethanol; Ethnicity; Fomepizole; Hispanic or Latino; Humans; Indians, Nor

2009
Head CT in patient with metabolic acidosis.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2008, Volume: 4, Issue:4

    Topics: Acid-Base Imbalance; Acidosis; Adult; Alcoholism; Anisocoria; Antidotes; Bicarbonates; Cerebral Hemo

2008
Ranitidine as an alcohol dehydrogenase inhibitor in acute methanol toxicity in rats.
    Human & experimental toxicology, 2010, Volume: 29, Issue:2

    Topics: Acidosis; Alcohol Dehydrogenase; Animals; Antidotes; Enzyme Inhibitors; Ethanol; Fomepizole; Formate

2010
Fomepizole fails to prevent progression of acidosis in 2-butoxyethanol and ethanol coingestion.
    Clinical toxicology (Philadelphia, Pa.), 2010, Volume: 48, Issue:6

    Topics: Acidosis; Alcohol Dehydrogenase; Antidotes; Disease Progression; Ethanol; Ethylene Glycols; Fomepizo

2010
Role of tissue metabolite accumulation in the renal toxicity of diethylene glycol.
    Toxicological sciences : an official journal of the Society of Toxicology, 2011, Volume: 123, Issue:2

    Topics: Acetates; Acidosis; Animals; Antidotes; Ethylene Glycols; Fomepizole; Kidney; Kidney Diseases; Male;

2011
Functional characterization of transmembrane intracellular pH regulators and mechanism of alcohol-induced intracellular acidosis in human umbilical cord blood stem cell-like cells.
    Journal of cardiovascular pharmacology, 2011, Volume: 58, Issue:6

    Topics: Acidosis; Amitrole; Antigens, CD34; Antiporters; Catalase; Cells, Cultured; Dose-Response Relationsh

2011
Fomepizole therapy for pediatric butoxyethanol intoxication.
    Journal of toxicology. Clinical toxicology, 2002, Volume: 40, Issue:7

    Topics: Acidosis; Adult; Antidotes; Ethylene Glycols; Female; Fomepizole; Humans; Pyrazoles; Solvents; Suici

2002
Treatment of severe pediatric ethylene glycol intoxication without hemodialysis.
    Journal of toxicology. Clinical toxicology, 2004, Volume: 42, Issue:3

    Topics: Acidosis; Adolescent; Antidotes; Bicarbonates; Child; Creatine; Disease Progression; Ethylene Glycol

2004
Ethylene glycol toxicity.
    Military medicine, 2004, Volume: 169, Issue:8

    Topics: Acidosis; Acute Kidney Injury; Adolescent; Critical Care; Emergency Treatment; Ethylene Glycol; Fema

2004
Outcomes following abuse of methanol-containing carburetor cleaners.
    Human & experimental toxicology, 2004, Volume: 23, Issue:10

    Topics: Acidosis; Adolescent; Adult; Antidotes; Ethanol; Female; Fluid Therapy; Fomepizole; Humans; Inhalati

2004
Methanol and formate kinetics during treatment with fomepizole.
    Clinical toxicology (Philadelphia, Pa.), 2005, Volume: 43, Issue:4

    Topics: Acidosis; Adult; Aged; Antidotes; Bicarbonates; Chromatography, Gas; Dialysis; Fomepizole; Formates;

2005
Fomepizole may change indication for hemodialysis in methanol poisoning: prospective study in seven cases.
    Clinical nephrology, 2005, Volume: 64, Issue:3

    Topics: Acidosis; Adult; Aged; Antidotes; Female; Follow-Up Studies; Fomepizole; Humans; Male; Methanol; Mid

2005
Change in mental status.
    The Journal of emergency medicine, 2007, Volume: 32, Issue:2

    Topics: Acidosis; Adult; Antidotes; Confusion; Depression; Drug Overdose; Ethylene Glycol; Fomepizole; Human

2007
Fomepizole (4-methylpyrazole) in fatal methanol poisoning with early CT scan cerebral lesions.
    Journal of toxicology. Clinical toxicology, 1999, Volume: 37, Issue:6

    Topics: Acidosis; Adult; Alcohol Dehydrogenase; Antidotes; Brain; Coma; Dialysis; Enzyme Inhibitors; Fatal O

1999
Role of acidosis in the changes of rat brain monoamines after methanol administration & effect of blocking methanol metabolism by 4-methyl pyrazole & 3-amino-1,2,4-triazole.
    The Indian journal of medical research, 1988, Volume: 88

    Topics: Acidosis; Amitrole; Animals; Brain Chemistry; Catecholamines; Fomepizole; Methanol; Pyrazoles; Rats;

1988