fomepizole has been researched along with Abnormalities, Drug-Induced in 4 studies
Fomepizole: A pyrazole and competitive inhibitor of ALCOHOL DEHYDROGENASE that is used for the treatment of poisoning by ETHYLENE GLYCOL or METHANOL.
fomepizole : A member of the class of pyrazoles that is 1H-pyrazole substituted by a methyl group at position 4.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The proximate teratogen of the fetal alcohol syndrome is unknown." | 1.27 | Determination of the proximate teratogen of the mouse fetal alcohol syndrome. 1. Teratogenicity of ethanol and acetaldehyde. ( Blakley, PM; Scott, WJ, 1984) |
| "3 mmol/kg, single dose concomitant with ME or additional ethanol 5 and 10 hr later) reduced the incidence of malformations 60-100%, depending on the dosing regimen." | 1.27 | The relationship of embryotoxicity to disposition of 2-methoxyethanol in mice. ( Greene, JA; Sleet, RB; Welsch, F, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Blakley, PM | 1 |
| Scott, WJ | 1 |
| Eisses, KT | 1 |
| Collins, MD | 1 |
| Eckhoff, C | 1 |
| Chahoud, I | 1 |
| Bochert, G | 1 |
| Nau, H | 1 |
| Sleet, RB | 1 |
| Greene, JA | 1 |
| Welsch, F | 1 |
4 other studies available for fomepizole and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Determination of the proximate teratogen of the mouse fetal alcohol syndrome. 1. Teratogenicity of ethanol and acetaldehyde.
Topics: Abnormalities, Drug-Induced; Acetaldehyde; Alcohol Dehydrogenase; Alcohol Oxidoreductases; Animals; | 1984 |
Differences in teratogenic and toxic properties of alcohol dehydrogenase inhibitors pyrazole and 4-methylpyrazole in Drosophila melanogaster: II. Adh allozymes in an isogenic background.
Topics: Abnormalities, Drug-Induced; Alcohol Dehydrogenase; Animals; Chromosome Mapping; Drosophila melanoga | 1994 |
4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse.
Topics: Abnormalities, Drug-Induced; Alcohol Dehydrogenase; Animals; Chromatography, High Pressure Liquid; D | 1992 |
The relationship of embryotoxicity to disposition of 2-methoxyethanol in mice.
Topics: Abnormalities, Drug-Induced; Acetates; Aldehyde Dehydrogenase; Animals; Carbon Radioisotopes; Embryo | 1988 |