folic acid has been researched along with Rheumatoid Arthritis in 239 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (13.39) | 18.7374 |
| 1990's | 44 (18.41) | 18.2507 |
| 2000's | 70 (29.29) | 29.6817 |
| 2010's | 60 (25.10) | 24.3611 |
| 2020's | 33 (13.81) | 2.80 |
| Authors | Studies |
|---|---|
| Abdelmoula, L; Ben Ahmed, H; Ben Tekaya, A; Bouden, S; Bouzid, K; Mahmoud, I; Rouached, L; Saidane, O; Tekaya, R | 1 |
| Ravaei, A; Rubini, M | 2 |
| Chhabra, M; Kumar, S; Rashid, M; Venkataraman, R; Zuber, M | 1 |
| Cao, X; Deng, X; Huang, D; Peng, W; Tu, H; Wang, R; Wang, X; Wu, M; Zhang, Z; Zhou, X; Zhu, H; Zhu, L | 1 |
| Du, Y; Ismail, M; Ling, L; Shan, Q; Song, Y; Zhang, L; Zhao, J; Zhu, Y | 1 |
| Geng, HX; Guo, RB; Kong, L; Li, XT; Liu, Y; Wang, YJ; Wu, YN; Yan, DK; Yu, YJ; Zhang, XY | 1 |
| Li, C; Li, X; Su, H; Wang, H; Zou, X | 1 |
| Beaino, W; Ezdoglian, A; Jansen, G; Khodadust, F; Low, PS; Molthoff, CFM; Srinivasarao, M; Steinz, MM; Tas, SW; van der Laken, CJ; Windhorst, AD; Yaqub, M; Zwezerijnen, GJC | 1 |
| Di, Y; Jiang, B; Wang, X; Xu, A; Yang, R; Zhang, M; Zhou, L; Zhou, Z | 1 |
| Jia, M; Li, C; Liu, Y; Lu, J; Mei, Z; Pan, H; Wang, C; Wang, Y; Zheng, X; Zhou, Y | 1 |
| Branco, JC; Santos, FP; Torres, RP | 1 |
| Oberhofer, E | 1 |
| Tanaka, Y | 1 |
| Li, G; Li, X; Li, Y; Lu, X; Sun, F; Teng, L; Yang, B; Zhang, M; Zhang, S | 1 |
| Han, Y; Huang, J; Li, C; Luo, X; Qian, C; Su, H; Yi, X | 1 |
| Krüger, K | 1 |
| Hu, Y; Liu, R; Liu, X; Yan, Q | 1 |
| Cui, G; Han, S; Li, J; Li, Z; Man, Y; Teng, L; Xue, B; Zhang, H | 1 |
| Lyu, H; Solomon, DH; Vanni, KMM | 1 |
| Dagnaes-Hansen, F; Jakobsen, M; Kjems, J; Nielsen, NC; Song, P; Vinding, MS; Vu-Quang, H | 1 |
| Damnjanovic, T; Jekic, B; Maksimovic, N | 1 |
| Bedoui, Y; Gasque, P; Giry, C; Guillot, X; Guiraud, P; Jaffar-Bandjee, MC; Ralandison, S; Sélambarom, J | 1 |
| Bruijnen, STG; Chen, Q; Hoekstra, OS; Jansen, G; Lammertsma, AA; Low, PS; Pieplenbosch, S; Ter Wee, MM; van der Laken, CJ; Verweij, NJF; Voskuyl, AE; Windhorst, AD; Yaqub, M | 1 |
| Aguilar, D; Chan, W; Deshmukh, AA; Sonawane, K; Suarez-Almazor, ME; Zhu, Y | 1 |
| Chikamori, A; Egashira, N; Hashimoto, M; Horiuchi, T; Kimoto, Y; Masuguchi, K; Murakami, T; Oryoji, D; Sasaki, K; Tsuji, T; Watanabe, H; Yanagihara, Y | 1 |
| Alqarni, AM; Zeidler, MP | 1 |
| Kaul, A; Kumar, V; Leekha, A; Mishra, AK; Verma, AK | 1 |
| Li, F; Li, J; Shi, L; Shu, J; Sun, X; Tang, J | 1 |
| Cai, L; Chen, X; Feng, Y; Li, C; Li, H; Mei, Z; Wang, Y; Yan, F; Zhong, Z | 1 |
| Mitsuboshi, S | 1 |
| Gniazdowska, E; Halik, PK; Koźmiński, P | 1 |
| Zewail, M | 1 |
| Bramley, D | 1 |
| Ahmed, EM; Al-Rahim, AM; Al-Saffar, AZ; Albukhaty, S; AlChalabi, R; Belali, T; Khalil, KAA; Sulaiman, GM | 1 |
| Hou, Y; Li, G; Li, X; Li, Y; Meng, X; Qi, Y; Sun, F; Teng, L; Xu, F; Zhang, S; Zhang, X | 1 |
| Chandrupatla, DMSH; Chen, Q; Jansen, G; Lammertsma, AA; Low, PS; Molthoff, CFM; van der Laken, CJ; Verlaan, M; Vos, R; Windhorst, AD | 1 |
| Alfredsson, L; Lourdudoss, C; Nise, L; Vollenhoven, RV; Wolk, A | 1 |
| Balanescu, A; Cen, L; Cohen, SB; Gomez-Reino, J; Kivitz, A; Scheinberg, M; Shisha, T; Smolen, JS; Tony, HP; Zhu, P | 1 |
| Cheng, X; Lee, RJ; Li, Y; Liu, J; Sun, F; Teng, L; Yu, C; Zhang, X; Zhao, J; Zhao, M | 1 |
| Ayala-López, W; Chelvam, V; Kelderhouse, LE; Low, PS; Poh, S; Putt, KS; Vaitilingam, B | 1 |
| Aceves, MA; Dávalos, IP; Dávalos, NO; Gallegos-Arreola, MP; Gámez-Nava, JI; González-López, L; González-Mercado, A; González-Mercado, MG; Macías-Chumacera, A; Medina-Coss Y León, R; Morán-Moguel, MC; Muñoz-Valle, JF; Rivas, F; Salazar-Páramo, M | 1 |
| Singh, D; Singh, MR; Srivastava, S | 1 |
| Cline, A; Jorizzo, JL | 1 |
| Chu, X; Fu, L; Hua, H; Li, N; Xu, C; Zeng, X; Zhang, N; Zhang, S; Zhao, Y | 1 |
| Akrout, R; Ayedi, F; Bahloul, Z; Ben Hamad, M; Chaabane, S; Keskes, L; Maalej, A; Marzouk, S; Messedi, M; Rebai, A; Turki, M | 1 |
| Lee, RJ; Li, Y; Sun, F; Sun, X; Teng, L; Yu, C; Zhang, X; Zhao, J; Zhao, M; Zhou, Y | 1 |
| Guan, W; He, Y; Hu, W; Li, T; Liu, L; Liu, S; Liu, X; Lu, J; Wang, C; Wang, P; Xuan, Y; Zhang, L; Zhang, Y | 1 |
| Barclay, M; Chapman, PT; Drake, J; Frampton, C; OʼDonnell, JL; Stamp, LK; Zhang, M | 1 |
| Ahmad, S; Bhatnagar, A; Dhawan, V; Dhir, V; Kaur, J; Sandhu, A | 1 |
| Bodakçi, E; Cansu, DÜ; Korkmaz, C; Teke, HÜ | 1 |
| Duan, W; Li, H | 1 |
| Chhatwal, J; Deshmukh, AA; Sonawane, K | 1 |
| Chandrupatla, DMSH; Jansen, G; Lammertsma, AA; Molthoff, CFM; van der Laken, CJ | 1 |
| Bulatović Ćalasan, M; de Jong, PHP; de Jonge, R; de Rotte, MCFJ; Hazes, JMW; Lindemans, J; Pluijm, SMF; Weel, AEAM; Wulffraat, NM | 1 |
| Baggott, JE; Morgan, SL | 3 |
| Dong, S; Lee, RJ; Li, X; Li, Y; Sun, F; Sun, X; Teng, L; Yu, K | 1 |
| Agrawal, GP; Jain, A; Jain, SK; Panda, PK; Saraf, S; Tiwari, A; Verma, A | 1 |
| Huang, Z; Wu, H; Wu, S; Xi, L; Zhu, Y; Zhu, Z | 1 |
| Berndt, R; Gassling, V; Kriegelstein, S; Troeltzsch, M; von Blohn, G; Woodlock, T | 1 |
| Bombardier, C; Katchamart, W; Ortiz, Z; Rader, T; Shea, B; Swinden, MV; Tanjong Ghogomu, E; Tugwell, P; Wells, GA | 1 |
| Masuko, K; Matsui, T; Tohma, S | 1 |
| Assaraf, YG; Blits, M; Jansen, G; Lems, WF; Nurmohamed, MT; van de Wiel, MA; van Schaardenburg, D; Verweij, CL; Voskuyl, AE; Vosslamber, S; Wolbink, GJ | 1 |
| Killock, D | 1 |
| Singh, JA | 1 |
| Bilthariya, U; Jain, AK; Jain, N; Rajoriya, V | 1 |
| Barendregt, PJ; Calasan, MB; de Jong, PH; de Jonge, R; de Rotte, MC; de Sonnaville, PB; Hazes, JM; Lindemans, J; Pluijm, SM; van der Lubbe, PA; van Zeben, D | 1 |
| Shea, B | 1 |
| Azevedo, R; Bernardes, M; Costa, L; Lima, A; Medeiros, R; Seabra, V; Sousa, H; Ventura, F | 1 |
| Nash, P; Nicholls, D | 1 |
| Bombardier, C; Ghogomu, ET; Katchamart, W; Ortiz, Z; Rader, T; Shea, B; Swinden, MV; Tugwell, P; Wells, GA | 1 |
| Bernardes, M; Canhão, H; Fonseca, JE; Lima, A; Romão, VC | 1 |
| Dhir, V; Gupta, N; Kaur, J; Kaur, P; Kumar, P; Pinto, B; Sandhu, A; Sharma, A; Sharma, S; Sood, A | 1 |
| Bosello, SL; Di Gregorio, F; Di Molfetta, V; Ferraccioli, G; Gremese, E; Mirone, L; Peluso, G; Pirronti, T | 1 |
| Cross, VA; Gehrke, MA; Hahn, SJ; Klein, PJ; Kleindl, PJ; Leamon, CP; Low, PS; Lu, Y; Parker, N; Santhapuram, HK; Stinnette, TW; Vaughn, JF; Vlahov, IR; Wang, K; Westrick, E; Wollak, K; You, F | 1 |
| Almeida, CR; Bernardes, GJ; Bismuth, G; Burnet, M; Carmo, AM; Cavaco-Paulo, A; Charvet, C; Freitas, J; Gomes, AC; Lager, F; Le Roux, D; Loureiro, A; Machacek, C; Moreira, A; Nogueira, E; Nogueira, P; Ohradanova-Repic, A; Preto, A; Renault, G; Stockinger, H | 1 |
| Chopra, A; Ghodke-Puranik, Y; Joshi, K; Lamba, J; Niewold, TB; Patwardhan, B; Puranik, AS; Shintre, P | 1 |
| Cavaco-Paulo, A; Gomes, AC; Nogueira, E; Preto, A | 1 |
| Hidaka, M; Hidaka, T; Kawakita, T; Migita, K; Mori, S; Tsuda, H; Ueki, Y; Yoshitama, T | 1 |
| Low, PS; Paulos, C; Varghese, B | 1 |
| Hauge, EM; Jensen-Fangel, S; Krogh, TP; Mortensen, KL | 1 |
| Cheah, CK; Gun, SC; Hong, HC; Koh, KT; Ling, GR; Teh, CL; Yong, MC | 1 |
| Anandasadagopan, SK; Manickavasagam, K; Periyathambi, P; Sastry, TP | 1 |
| Boscardin, WJ; Daikh, DI; Gannon, J; Miao, Y; Schmajuk, G; Steinman, MA; Tonner, C; Yazdany, J | 1 |
| Li, Y; Shao, W; Yuan, Y | 1 |
| Bohanec Grabar, P; Dolzan, V; Lestan, B; Logar, D | 1 |
| Eidner, T; Gundermann, C; Hartmann, M; Hein, G; Richter, A | 1 |
| Paul, C; Prey, S | 1 |
| Cheng, JX; Hilgenbrink, AR; Lockwood, MB; Low, PS; Matteson, EL; Xia, W | 1 |
| Akioka, T; Hanafusa, T; Hara, S; Hirata, Y; Kobayashi, K; Miyoshi, T; Nakayama, S; Takubo, T; Tsuji, M; Yokote, T | 1 |
| Fukushi, J; Iwamoto, Y; Nakashima, Y | 1 |
| Erov, NK; Sergiets, NA | 1 |
| Dijkmans, BA; Horikx, A; van den Bemt, BJ; van der Waal, RI; Verduijn, MM | 1 |
| Dervieux, T; Guchelaar, HJ; Kremer, JM; Moore, JH; Penrod, N; van der Straaten, T; Wessels, JA | 1 |
| Barclay, ML; Chapman, PT; Frampton, C; James, J; O'Donnell, JL; Stamp, LK; Zhang, M | 1 |
| BORDEN, AL; STEPHENS, CA | 1 |
| Barclay, ML; Chapman, PT; Frampton, C; James, J; Kennedy, MA; O'Donnell, JL; Roberts, RL; Stamp, LK; Zhang, M | 1 |
| Baggott, JE; Tamura, T | 1 |
| Böttcher, A; Guder, E; Just, T | 1 |
| Dimic, A; Liu, Y; Mease, P; Raskina, T; Shalamberidze, L; Smith, J; Strand, V; Xu, LA | 1 |
| Combe, B; Dougados, M; Gaujoux-Viala, C; Paternotte, S | 1 |
| Bergstrom, A; Bird, HA | 1 |
| Alarcón, GS; Baggott, JE; Koopman, WJ; Morgan, SL | 1 |
| Chaoui, R; Huch, A; Krähenmann, F; Stallmach, T; ØStensen, M | 1 |
| Christensen, PB; Ekelund, S; Hansen, H; Jensen, OK; Mollerup, F; Rasmussen, C; Thulstrup, AM | 1 |
| Slot, O | 2 |
| De Abreu, RA; Laan, RF; Stegeman, AB; van de Putte, LB; van Ede, AE | 1 |
| Houtman, PM; Jansen, TL; Spoorenberg, A; van Roon, EN | 1 |
| Suzuki, Y | 2 |
| Hughes, J; Jebb, SA; Lang, R; Rennie, KL | 1 |
| Haagsma, CJ; Hoekstra, M; Huizinga, TW; Kruijsen, MW; Laan, RF; van de Laar, MA; van Ede, AE | 1 |
| Aarden, LA; de Groot, ER; de Lathouder, S; Dijkmans, BA; Gerards, AH | 1 |
| Almog, S; Bar-Meir, S; Chowers, Y; Fishbein, E; Halkin, H; Kurnik, D; Loebstein, R | 1 |
| Lalukotta, K; Saravana, S | 1 |
| GOUGH, KR; MCCARTHY, C; MOLLIN, DL; READ, AE; WATERS, AH | 1 |
| CHALMERS, TM; MCCARTHY, DD | 1 |
| MACGIBBON, BH; MOLLIN, DL | 1 |
| Bernelot Moens, HJ; Haagsma, CJ; Hoekstra, M; Kruijsen, MW; van de Laar, MA | 1 |
| Hughes, RA; Whittle, SL | 1 |
| Breur, GJ; Low, PS; Paulos, CM; Turk, MJ | 1 |
| Hartman, M; Laan, RF; Severens, JL; van de Putte, L; van der Wilt, GJ; van Ede, A | 1 |
| Assaraf, YG; Dijkmans, BA; Ifergan, I; Jansen, G; Lems, WF; Oerlemans, R; Scheper, RJ; van der Heijden, J | 1 |
| Bamji, A | 1 |
| Ahn, MJ; Bae, SC; Choi, BR; Jun, JB; Kim, TH; Lee, WS | 1 |
| Kent, PD; Luthra, HS; Michet, C | 1 |
| Aamar, S; Abou Atta, I; Ben-Yehuda, A; Berkun, Y; Friedman, G; Grenader, T; Levartovsky, D; Mevorach, D; Orbach, H; Rubinow, A | 1 |
| Fransen, J; Huizinga, TW; Laan, RF; Van Der Laar, MA; Van Riel, PL | 1 |
| Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL; Oster, RA | 1 |
| Ellingsen, T; Hornung, N; Poulsen, JH; Stengaard-Pedersen, K | 1 |
| Doelman, CJ; Haagsma, CJ; Hoekstra, M; van de Laar, MA | 1 |
| Barut, Y; Direskeneli, H; Inanc, N; Ozdemir, A; Sahinoglu, S; Tarcin, O; Tiftikci, A; Uras, F; Yavuz, S | 1 |
| Cammarota, G; Diaco, M; Gasbarrini, G; Manna, R; Montalto, M; Verrecchia, E | 1 |
| Fasihi, T; Kirsner, RS; Ma, F; Pezon, C; Prodanovich, S; Prodanowich, S; Taylor, JR | 1 |
| Jackson, K; Suzuki, Y; Wakabayashi, T | 1 |
| Cronstein, BN | 1 |
| Clare, G; Colley, S; Elston, JS; Kennett, R | 1 |
| Cohen, SB; Dorrier, C; Elashoff, D; Emery, P; Furst, DE; Khanna, D; Park, GS; Paulus, HE; Simpson, KM | 1 |
| Chandrashekara, S; Patil, R; Shobha, A; Vadiraja, HS | 1 |
| Kim, YI | 1 |
| Caldwell, JR; Dervieux, T; Furst, DE; Kremer, JM; Park, GS; Smith, KM; Wallace, DJ; Weisman, MH | 1 |
| Alarcón, GS; Baggott, JE; Morgan, SL | 1 |
| Osone, Y | 1 |
| Aggarwal, A; Aggarwal, P; Mishra, KP; Misra, R; Naik, S | 1 |
| Goldsmith, P; Roach, A | 1 |
| Arabelovic, S; Dallal, GE; Jacques, PF; Rosenberg, IH; Roubenoff, R; Sam, G; Selhub, J | 1 |
| Drozdzik, M; Herczynska, M; Kurzawski, M; Pawlik, A; Safranow, K | 1 |
| Guchelaar, HJ; Huizinga, TW; Wessels, JA | 1 |
| Manore, MM; Woolf, K | 1 |
| Cleland, LG; Gillis, D; Hissaria, P; James, HM; Lester, S; Proudman, SM; Somogyi, AA | 1 |
| Arvai, I; Csák, E; Gömör, B; Jósfay, L; Megyeri, A; Revicky, A; Rinhelhann, B | 1 |
| Podell, RN | 1 |
| Cooper, BA | 1 |
| Kavanaugh, A; Kavanaugh, D | 1 |
| Shiroky, JB | 1 |
| Clark, D; Hunter, M; Hurst, NP; Jobanputra, P; Lambert, CM | 1 |
| Fogari, RA; Hoch, S | 1 |
| Cannon, JG; Dinarello, CA; Freeman, LM; Nadeau, MR; Rosenberg, IH; Roubenoff, R; Roubenoff, RA; Selhub, J | 1 |
| Alarcón, GS; Austin, JS; Baggott, JE; Koopman, WJ; Krumdieck, CL; Lee, JY; Morgan, SL; Vaughn, WH; Veitch, TA | 1 |
| Alarcón, GS; Baggott, JE; Koopman, WJ; Krumdieck, CL; Morgan, SL | 2 |
| Alarcón, GS; Krumdieck, CL; Morgan, Sl | 1 |
| al-Awadhi, A; Dale, P; McKendry, RJ | 1 |
| Dijkmans, BA | 1 |
| Beyeler, C | 1 |
| Kim, YI; Logan, JW; Mason, JB; Roubenoff, R | 1 |
| Ekelund, S; Krogh Jensen, M; Svendsen, L | 1 |
| Laroche, F; Menkès, CJ; Perrot, S | 1 |
| Tett, SE; Triggs, EJ | 1 |
| Kremer, JM | 1 |
| Berthelot, JM; Maugars, Y; Prost, A | 1 |
| Alarcón, GS; Morgan, SL | 1 |
| Andersen, LS; Hansen, EL; Hansen, GV; Hansen, TM; Knudsen, JB; Wester, JU | 1 |
| Moher, D; Ortiz, Z; Shea, B; Suarez-Almazor, ME; Tugwell, P; Wells, GA | 1 |
| Alarcón, GS; Baggott, JE; Lee, JY; Morgan, SL | 1 |
| Blom, HJ; De Abreu, RA; Laan, RF; van de Putte, LB; van Ede, AE | 1 |
| Doube, A | 1 |
| De Miguel, E; Hernanz, A; Martín-Mola, E; Plaza, A | 1 |
| Endresen, GK; Husby, G | 2 |
| Blom, HJ; Giesendorf, BA; Haagsma, CJ; van de Putte, LB; van Oppenraaij-Emmerzaal, D; van Riel, PL; van't Hof, MA | 1 |
| Homma, T; Matsuda, T; Matsuyama, T; Nakamura, T; Nakashima-Matsushita, N; Ratnam, M; Sunahara, N; Tsukano, M; Yu, S | 1 |
| Ichikawa, Y; Ide, M; Mizushima, Y; Noguchi, A; Suzuki, Y; Tajima, C; Uehara, R | 1 |
| Coleiro, B; Mallia, C | 1 |
| Schiff, MH | 1 |
| Moher, D; Ortiz, Z; Shea, B; Suarez Almazor, M; Tugwell, P; Wells, G | 1 |
| Bressolle, F; Combe, B; Kinowski, JM; Morel, J; Pouly, B; Sany, J | 1 |
| Clarke, S; Dawes, PT; Fisher, J; Griffith, SM; Hassell, AB; Hay, EM; Hothersall, TE; Jones, PW; Montgomery, B; Saklatvala, J; Shadforth, MF | 1 |
| Alarcón, GS; Baggott, JE; Morgan, SL; Strand, V | 1 |
| Capell, HA; Hamilton, J; Hunter, JA; Madhok, R; McInnes, IB; Porter, D; Thomson, EA | 1 |
| Harten, P | 1 |
| Erb, N; Kitas, GD | 1 |
| Breedveld, FC; de Boo, TM; de Rooij, DJ; Dijkmans, BA; Hartman, M; Huizinga, TW; Jacobs, MJ; Krabbe, PF; Laan, RF; Romme, TC; Rood, MJ; Severens, JL; van de Laar, MA; van de Putte, LB; van Denderen, CJ; van der Wilt, GJ; van Ede, AE; Westgeest, TA | 1 |
| Blom, HJ; de Boo, TM; Giesendorf, BA; Haagsma, CJ; Huizinga, TW; Laan, RF; van de Putte, LB; van Ede, AE | 1 |
| Eichholzer, M; Gutzwiller, F; Lüthy, J; Moser, U; Stähelin, HB | 1 |
| Benamouzig, R; Chaussade, S | 1 |
| Blom, HJ; Boers, GH; De Boo, TM; Haagsma, CJ; Laan, RF; Thomas, CM; van de Putte, LB; van Ede, AE | 1 |
| Blair, JA; Cooke, WT; Leeming, RJ; Melikian, V; Thien, KR | 1 |
| Bayliss, CE; Davis, RE; Sanderson, CR | 1 |
| Bruyn, GA; Houtman, PM; Stenger, AA | 1 |
| Alarcón, GS; Castañeda, O; Ferrándiz, M; Koopman, WJ; Krumdieck, CL | 1 |
| Baggott, JE; Ha, T; Hine, RJ; Morgan, SL; Vaughn, WH | 1 |
| Olsen, NJ; Peters, LJ | 1 |
| Baggott, JE; Morgan, SL; Refsum, H; Ueland, PM | 1 |
| Jaffe, IA | 1 |
| Clough, JD; Perhala, RS; Segal, AM; Wilke, WS | 1 |
| Clough, JD; Mackenzie, AH; Stewart, KA; Wilke, WS | 1 |
| Alarcòn, GS; Baggott, JE; Everson, MP; Hardin, JM; Hine, RJ; Koopman, WJ; Krumdieck, CL; Morgan, SL | 1 |
| Segal, R; Tartakovsky, B; Yaron, M | 1 |
| Miller, A | 1 |
| Alarcón, GS; Austin, JV; Baggott, JE; Krumdieck, CL; Morgan, SL; Vaughn, WH; Young, PK | 1 |
| Galivan, J; Kamen, B; Kremer, JM; Streckfuss, A | 1 |
| Davis, RE | 1 |
| Altz-Smith, M; Baggott, JE; Morgan, SL | 1 |
| Christensen, ML; Evans, WE | 1 |
| Mowat, A | 1 |
| Mikolajew, M; Plachecka-Gutowska, M; Wartanowicz, M | 1 |
| Fanelli, V | 1 |
| Mowat, AG; Omer, A | 2 |
| Mowat, AG | 1 |
| Beavon, JR; Blair, JA; Dransfield, E; Leeming, RJ; Ratanasthien, K; Staff, FJ | 1 |
| Innes, EH | 1 |
| Cervini, C | 1 |
| Jordan, PH; Kao, YS; Laughter, AH; Lidsky, MD; Twomey, JJ; Villanueva, ND | 1 |
| Chanarin, I; England, JM | 1 |
| Dyer, NH; Hawkins, CF; Kendall, MJ | 1 |
| Griffiths, HJ; Nicholson, WJ; O'Gorman, P | 1 |
| Einhorn, J; Elman, A; Ohlagen, B; Reizenstein, P | 1 |
| Thomas, JH | 1 |
| Alter, HJ; Rath, CE; Zvaifler, NJ | 1 |
| Cohen, C | 1 |
| Deller, DJ; Horwood, J; Ibbotson, RN; Milazzo, S; Robson, HN; Urban, E | 1 |
| Kajander, A; Markkanen, T | 1 |
51 review(s) available for folic acid and Rheumatoid Arthritis
| Article | Year |
|---|---|
Methotrexate related cutaneous adverse drug reactions: a systematic literature review.
Topics: Adolescent; Adult; Aged; Arthritis, Rheumatoid; Child; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Psoriasis; Spondylitis, Ankylosing; Young Adult | 2022 |
Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis.
Topics: Animals; Arthritis, Rheumatoid; Folate Receptor 2; Folic Acid; Folic Acid Antagonists; Humans; Macrophages; Positron-Emission Tomography | 2022 |
Methotrexate: Implications of pharmacogenetics in the treatment of patients with Rheumatoid Arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Humans; Methotrexate; Pharmacogenetics; Polymorphism, Single Nucleotide | 2022 |
Subcutaneous injection of methotrexate: Advantages in the treatment of rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Humans; Injections, Subcutaneous; Methotrexate; Treatment Outcome | 2023 |
Cytopenias among patients with rheumatic diseases using methotrexate: a meta-analysis of randomized controlled clinical trials.
Topics: Anemia; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Humans; Leucovorin; Leukopenia; Methotrexate; Neutropenia; Pancytopenia; Randomized Controlled Trials as Topic; Rheumatic Diseases; Severity of Illness Index; Thrombocytopenia; Vitamin B Complex | 2020 |
Methotrexate pharmacogenetics in the treatment of rheumatoid arthritis.
Topics: Adenosine; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Humans; Methotrexate; Middle Aged; Pharmacogenetics; Polymorphism, Genetic | 2019 |
Methotrexate an Old Drug with New Tricks.
Topics: Adenosine; Alarmins; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis; Arthritis, Rheumatoid; Cytokines; Folic Acid; HMGB1 Protein; Humans; Immunity, Innate; Inflammation; Matrix Metalloproteinases; Methotrexate; NF-kappa B; Polyamines; Prostaglandins; Reactive Oxygen Species | 2019 |
How does methotrexate work?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Autoimmune Diseases; Cell Line; Crohn Disease; Folic Acid; Humans; Inflammation; Janus Kinases; MAP Kinase Signaling System; Methotrexate; Psoriasis; Signal Transduction; STAT Transcription Factors | 2020 |
What dose of folic acid to use with methotrexate in rheumatoid arthritis?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Combinations; Folic Acid; Humans; Methotrexate; Vitamin B Complex | 2021 |
Folate Supplementation for Methotrexate Therapy in Patients With Rheumatoid Arthritis: A Systematic Review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Humans; Leucovorin; Methotrexate | 2019 |
The folate receptor β as a macrophage-mediated imaging and therapeutic target in rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Folate Receptor 2; Folic Acid; Folic Acid Antagonists; Humans; Macrophages; Positron-Emission Tomography | 2019 |
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Topics: Abdominal Pain; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Folic Acid Antagonists; Gastrointestinal Diseases; Hematologic Diseases; Humans; Leucovorin; Methotrexate; Nausea; Vomiting | 2013 |
Potential food-drug interactions in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Calcineurin; Calcineurin Inhibitors; Citrus paradisi; Enzyme Inhibitors; Folic Acid; Food-Drug Interactions; Fruit; Humans; Isoniazid; Methotrexate; Risk Factors; Seafood | 2013 |
Folic acid or folinic acid for reducing side effects of methotrexate for people with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Evidence-Based Medicine; Folic Acid; Humans; Immunosuppressive Agents; Leucovorin; Methotrexate; Review Literature as Topic | 2013 |
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Humans; Leucovorin; Male; Methotrexate | 2014 |
Three decades of low-dose methotrexate in rheumatoid arthritis: can we predict toxicity?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Carrier Proteins; Dietary Supplements; Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Methotrexate; Pharmacogenetics; Prognosis; Signal Transduction | 2014 |
Folate-targeted nanoparticles for rheumatoid arthritis therapy.
Topics: Arthritis, Rheumatoid; Drug Delivery Systems; Folate Receptor 2; Folic Acid; Gene Expression Regulation; Humans; Macrophage Activation; Macrophages; Nanoparticles; Synovial Membrane | 2016 |
Association Between MTHFR C677T Polymorphism and Methotrexate Treatment Outcome in Rheumatoid Arthritis Patients: A Systematic Review and Meta-Analysis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Female; Folic Acid; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Treatment Outcome; White People | 2017 |
Effect of folic or folinic acid supplementation on methotrexate-associated safety and efficacy in inflammatory disease: a systematic review.
Topics: Arthritis, Rheumatoid; Chemical and Drug Induced Liver Injury; Drug Eruptions; Folic Acid; Gastrointestinal Diseases; Hematologic Diseases; Humans; Immunosuppressive Agents; Leucovorin; Liver Diseases; Methotrexate; Psoriasis; Randomized Controlled Trials as Topic | 2009 |
Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase.
Topics: Administration, Oral; Animals; Arthritis, Rheumatoid; Carbon; Cytochromes c; Folic Acid; Humans; Kinetics; Methotrexate; Mitochondria; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Purines; Recombinant Proteins; Substrate Specificity | 2010 |
[Methotrexate for the treatment of rheumatoid arthritis in Japan--much more still remains to be resolved].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid; Humans; Methotrexate | 2002 |
Nutritional management of rheumatoid arthritis: a review of the evidence.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Arthritis, Rheumatoid; Calcium, Dietary; Dietary Supplements; Fatty Acids, Monounsaturated; Fatty Acids, Omega-3; Folic Acid; Humans; Nutritional Physiological Phenomena; Nutritional Status; Vitamin B Complex; Vitamin D | 2003 |
Folate supplementation and methotrexate treatment in rheumatoid arthritis: a review.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate | 2004 |
Folate receptor-mediated targeting of therapeutic and imaging agents to activated macrophages in rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Carrier Proteins; Drug Delivery Systems; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Macrophage Activation; Macrophages; Radioisotopes; Radionuclide Imaging; Receptors, Cell Surface | 2004 |
Methotrexate reduces incidence of vascular diseases in veterans with psoriasis or rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; Cohort Studies; Comorbidity; Databases, Factual; Drug Synergism; Drug Therapy, Combination; Female; Florida; Folic Acid; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Incidence; Male; Medical Records Systems, Computerized; Methotrexate; Middle Aged; Psoriasis; Retrospective Studies; Risk; Vascular Diseases; Veterans | 2005 |
[Methotrexate for therapy of rheumatoid arthritis].
Topics: Antibodies, Monoclonal; Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Therapy, Combination; Etanercept; Evidence-Based Medicine; Folic Acid; Humans; Immunoglobulin G; Infliximab; Lung Diseases, Interstitial; Methotrexate; Receptors, Tumor Necrosis Factor | 2005 |
[Methotrexate].
Topics: Activities of Daily Living; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Monitoring; Folic Acid; Humans; Immunosuppressive Agents; Methotrexate; Prognosis | 2005 |
5,10-Methylenetetrahydrofolate reductase polymorphisms and pharmacogenetics: a new role of single nucleotide polymorphisms in the folate metabolic pathway in human health and disease.
Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Arthritis, Rheumatoid; Folic Acid; Humans; Neoplasms; Pharmacogenetics; Polymorphism, Genetic; Polymorphism, Single Nucleotide | 2005 |
[Methotrexate therapy for rheumatism and collagen diseases].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Collagen Diseases; Folic Acid; Humans; Methotrexate | 2002 |
Recent insights in the pharmacological actions of methotrexate in the treatment of rheumatoid arthritis.
Topics: Adenosine; Animals; Apoptosis; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Clinical Trials as Topic; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Folic Acid; Humans; Immunity, Cellular; Immunosuppression Therapy; Male; Methotrexate; Reactive Oxygen Species; Sensitivity and Specificity; Treatment Outcome | 2008 |
The 'tomato effect' in clinical nutrition. New treatments languishing on the vine?
Topics: Adult; Arthritis, Rheumatoid; Aspirin; Attitude to Health; Cardiovascular Diseases; Child; Colchicine; Coronary Disease; Diet; Drug Evaluation; Eczema; Female; Fish Oils; Folic Acid; Food Hypersensitivity; Gold; Gout; Humans; Hypoglycemia; Magnesium; Sleep; Tryptophan; Uterine Cervical Dysplasia | 1984 |
Folate supplementation and methotrexate.
Topics: Antidotes; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Hematinics; Humans; Leucovorin; Methotrexate | 1995 |
[Methotrexate treatment of rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Protocols; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate | 1996 |
Methotrexate update.
Topics: Antidotes; Antirheumatic Agents; Arthritis, Rheumatoid; Dermatologic Agents; Drug Therapy, Combination; Folic Acid; Hematinics; Humans; Kidney; Leucovorin; Liver; Lung; Methotrexate; Psoriasis | 1996 |
Pancytopenia secondary to methotrexate therapy in rheumatoid arthritis: comment on the article by Gutierrez-Ureña et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Bone Marrow; Folic Acid; Humans; Methotrexate; Pancytopenia | 1997 |
The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A metaanalysis of randomized controlled trials.
Topics: Adult; Antidotes; Antimetabolites, Antineoplastic; Arthritis, Rheumatoid; Drug Interactions; Folic Acid; Hematinics; Humans; Leucovorin; Methotrexate; Randomized Controlled Trials as Topic | 1998 |
Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate | 1998 |
[Methotrexate and folates in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Randomized Controlled Trials as Topic | 1999 |
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Folic Acid Antagonists; Gastrointestinal Diseases; Hematologic Diseases; Humans; Leucovorin; Methotrexate | 2000 |
Folate supplementation during methotrexate treatment of patients with rheumatoid arthritis. An update and proposals for guidelines.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Humans; Methotrexate; Practice Guidelines as Topic | 2001 |
[Safety aspects of folic acid for the general population].
Topics: Adult; Animals; Anticonvulsants; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Child; Cohort Studies; Double-Blind Method; Drug Hypersensitivity; Drug Interactions; Epilepsy; Female; Folic Acid; Folic Acid Antagonists; Humans; Infant, Newborn; Male; Methotrexate; Middle Aged; Multicenter Studies as Topic; Placebos; Pregnancy; Randomized Controlled Trials as Topic; Risk Factors; Time Factors; Vitamin B 12 Deficiency; Zinc | 2002 |
[Chemoprevention of colorectal cancer].
Topics: Adenomatous Polyposis Coli; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Arthritis, Rheumatoid; Aspirin; Calcium, Dietary; Case-Control Studies; Cohort Studies; Colorectal Neoplasms; Controlled Clinical Trials as Topic; Cyclooxygenase Inhibitors; Dietary Supplements; Eflornithine; Enzyme Inhibitors; Female; Folic Acid; Hormone Replacement Therapy; Humans; Male; Mice; Mice, Knockout; Middle Aged; Risk Factors; Sulindac; Time Factors; Vitamins | 2002 |
Does folate supplementation make sense in patients with rheumatoid arthritis treated with methotrexate?
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Humans; Leucovorin; Methotrexate | 1992 |
Mechanisms of action of methotrexate.
Topics: Arthritis, Rheumatoid; Endothelium; Fibroblasts; Folic Acid; Humans; Immunosuppression Therapy; Inflammation; Methotrexate | 1991 |
Modern management of rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Methotrexate | 1991 |
Methotrexate: mechanism of action in rheumatoid arthritis.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antibody Formation; Arthritis, Rheumatoid; Cell Division; Collagen; Cytokines; Endopeptidases; Folic Acid; Humans; Immunity, Cellular; Methotrexate; Monocytes | 1990 |
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biological Assay; Biological Transport; Bone Marrow; Carrier Proteins; Chemical Phenomena; Chemistry; Contraceptives, Oral; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Food Analysis; Formiminoglutamic Acid; Glutamate Formimidoyltransferase; Humans; Hydroxymethyl and Formyl Transferases; Infant; Infant Nutritional Physiological Phenomena; Infant, Newborn; Infections; Kidney Failure, Chronic; Malabsorption Syndromes; Malaria; Methotrexate; Neoplasms; Nervous System Diseases; Nutritional Requirements; Parenteral Nutrition, Total; Pregnancy; Pyrimethamine; Receptors, Cell Surface; Terminology as Topic; Thalassemia; Transferases; Trimethoprim | 1986 |
Drug interactions with methotrexate.
Topics: Absorption; Anti-Bacterial Agents; Arthritis, Rheumatoid; Aspirin; Biological Transport; Cell Membrane; Cisplatin; Dose-Response Relationship, Drug; Drug Interactions; Folic Acid; Humans; Kidney Tubules; Methotrexate; Probenecid; Protein Binding; Salicylates; Serum Albumin; Sulfamethoxazole; Sulfonamides; Tissue Distribution | 1985 |
Connective tissue diseases.
Topics: Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Megaloblastic; Arthritis, Juvenile; Arthritis, Rheumatoid; Blood Volume; Collagen Diseases; Dermatomyositis; Felty Syndrome; Folic Acid; Hemolysis; Humans; Hyperplasia; Iron; Lupus Erythematosus, Systemic; Myositis; Polyarteritis Nodosa; Polymyalgia Rheumatica; Scleroderma, Systemic; Vitamin B 12 | 1972 |
Hematologic abnormalities in rheumatoid arthritis.
Topics: Adrenocorticotropic Hormone; Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Sideroblastic; Arthritis, Rheumatoid; Felty Syndrome; Folic Acid; Folic Acid Deficiency; Gastrointestinal Hemorrhage; Hemolysis; Humans; Hyperplasia; Intestinal Absorption; Iron; Mononuclear Phagocyte System; Plasma Volume; Vitamin B 12 Deficiency | 1972 |
[Anemia in rheumatoid arthritis: features of pathogenesis and therapy].
Topics: Anemia; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Sideroblastic; Arthritis, Rheumatoid; Bone Marrow; Cobalt; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Gastric Acidity Determination; Hemoglobinometry; Humans; Intestinal Absorption; Iron; Liver Extracts; Male; Mononuclear Phagocyte System; Plasma Volume; Potassium; Salicylates; Sex Factors; Steroids; Vitamin B 12 | 1970 |
30 trial(s) available for folic acid and Rheumatoid Arthritis
| Article | Year |
|---|---|
A randomised, double-blind trial to demonstrate bioequivalence of GP2013 and reference rituximab combined with methotrexate in patients with active rheumatoid arthritis.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; Biosimilar Pharmaceuticals; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Rituximab; Therapeutic Equivalency; Treatment Outcome; Vitamin B Complex; Young Adult | 2017 |
A Pilot Randomized Controlled Double-Blind Trial of High- Versus Low-Dose Weekly Folic Acid in People With Rheumatoid Arthritis Receiving Methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Monitoring; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Patient Acuity; Pilot Projects; Treatment Outcome; Vitamin B Complex | 2019 |
Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Drug Monitoring; Erythrocytes; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Predictive Value of Tests; Prospective Studies; Vitamin B 12; Vitamin B 6 | 2013 |
Comparison of two different folic acid doses with methotrexate--a randomized controlled trial (FOLVARI Study).
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged | 2015 |
A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages.
Topics: Aged; Animals; Antigens, CD; Arthritis, Rheumatoid; Carrier Proteins; Drug Delivery Systems; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Macrophage Activation; Macrophages, Peritoneal; Male; Mice; Oligopeptides; Radiography; Radionuclide Imaging; Radiopharmaceuticals; Reactive Oxygen Species; Receptors, Cell Surface; Tumor Necrosis Factor-alpha; Up-Regulation | 2009 |
[Combined basic therapy of rheumatoid arthritis with methotrexate and plaquenil].
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Folic Acid; Humans; Hydroxychloroquine; Immunosuppressive Agents; Male; Methotrexate; Middle Aged; Young Adult | 2009 |
Methotrexate polyglutamate concentrations are not associated with disease control in rheumatoid arthritis patients receiving long-term methotrexate therapy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Erythrocyte Count; Erythrocytes; Female; Folic Acid; Glutamic Acid; Humans; Joints; Male; Methotrexate; Middle Aged; Polyglutamic Acid; Young Adult | 2010 |
A phase II, double-blind, randomised, placebo-controlled study of BMS945429 (ALD518) in patients with rheumatoid arthritis with an inadequate response to methotrexate.
Topics: Analgesics; Antibodies, Monoclonal, Humanized; Antirheumatic Agents; Arthritis, Rheumatoid; Aspirin; Double-Blind Method; Drug Substitution; Drug Therapy, Combination; Female; Folic Acid; Health Status; Humans; Injections, Intravenous; Joints; Male; Methotrexate; Middle Aged; Prednisolone; Remission Induction; Severity of Illness Index; Treatment Failure; Treatment Outcome | 2012 |
Factors associated with toxicity, final dose, and efficacy of methotrexate in patients with rheumatoid arthritis.
Topics: Adult; Age Factors; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Body Mass Index; Chemical and Drug Induced Liver Injury; Creatinine; Digestive System; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Severity of Illness Index; Sex Factors; Treatment Outcome | 2003 |
Bioavailability of oral vs. subcutaneous low-dose methotrexate in patients with Crohn's disease.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Arthritis, Rheumatoid; Biological Availability; Crohn Disease; Cross-Over Studies; Drug Combinations; Female; Folic Acid; Half-Life; Humans; Male; Methotrexate; Middle Aged | 2003 |
Economic evaluation of folate supplementation during methotrexate treatment in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cost of Illness; Cost-Benefit Analysis; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Health Care Costs; Hematinics; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Patient Dropouts; Rheumatology; Time Factors | 2004 |
Influence of guideline adherence on outcome in a randomised controlled trial on the efficacy of methotrexate with folate supplementation in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Decision Making; Double-Blind Method; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Guideline Adherence; Humans; Male; Methotrexate; Middle Aged; Practice Guidelines as Topic; Survival Analysis; Treatment Outcome | 2004 |
The effect of folic acid and folinic acid supplements on purine metabolism in methotrexate-treated rheumatoid arthritis.
Topics: Adenosine; Aminoimidazole Carboxamide; Arthritis, Rheumatoid; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Purines; Pyridoxine; Ribonucleotides; Treatment Outcome; Vitamin B 12 | 2004 |
Reduction of the efficacy of methotrexate by the use of folic acid: post hoc analysis from two randomized controlled studies.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Female; Folic Acid; Hematinics; Humans; Immunosuppressive Agents; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; Treatment Outcome | 2005 |
The incidence of Proteus mirabilis infection increases in patients on treatment but does not trigger disease activity.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Bacterial; Antibody Specificity; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Follow-Up Studies; Humans; Hydroxychloroquine; Immunoglobulins; Male; Methotrexate; Middle Aged; Proteus Infections; Proteus mirabilis; Remission Induction; Serologic Tests; Steroids | 2006 |
677C>T and 1298A>C MTHFR polymorphisms affect methotrexate treatment outcome in rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; DNA; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Folic Acid; Gene Frequency; Genotype; Humans; Logistic Models; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Methylprednisolone; Middle Aged; Polymorphism, Restriction Fragment Length; Treatment Outcome | 2007 |
Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial.
Topics: Adult; Aged; Arthritis, Rheumatoid; Diet; Double-Blind Method; Drug Therapy, Combination; Erythrocytes; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Patient Dropouts; Treatment Outcome; Vitamin B 12 | 1994 |
Prospectively measured red cell folate levels in methotrexate treated patients with rheumatoid arthritis: relation to withdrawal and side effects.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Lactoglobulins; Male; Methotrexate; Middle Aged; Prospective Studies; Radioligand Assay; Substance Withdrawal Syndrome | 1997 |
Folic acid supplementation prevents deficient blood folate levels and hyperhomocysteinemia during longterm, low dose methotrexate therapy for rheumatoid arthritis: implications for cardiovascular disease prevention.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Homocysteine; Humans; Male; Methotrexate; Middle Aged | 1998 |
Influence of sulphasalazine, methotrexate, and the combination of both on plasma homocysteine concentrations in patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Digestive System; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Sulfasalazine; Vitamin B 12 | 1999 |
Leflunomide versus methotrexate: a comparison of the European and American experience.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Europe; Female; Folic Acid; Humans; Isoxazoles; Leflunomide; Male; Methotrexate; Middle Aged; United States | 1999 |
Folic acid alters methotrexate availability in patients with rheumatoid arthritis.
Topics: Adult; Aged; Arthritis, Rheumatoid; Drug Interactions; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged | 2000 |
Do patients with rheumatoid arthritis established on methotrexate and folic acid 5 mg daily need to continue folic acid supplements long term?
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Drug Administration Schedule; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Prospective Studies; Treatment Outcome | 2000 |
Comparative study of intramuscular gold and methotrexate in a rheumatoid arthritis population from a socially deprived area.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Glucocorticoids; Gold Sodium Thiomalate; Health Status Indicators; Humans; Male; Methotrexate; Middle Aged; Pain Measurement; Poverty Areas; Treatment Outcome | 2001 |
Effect of folic or folinic acid supplementation on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a forty-eight week, multicenter, randomized, double-blind, placebo-controlled study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Folic Acid; Hematinics; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Placebos; Prospective Studies; Treatment Outcome | 2001 |
The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients.
Topics: Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Hematinics; Humans; Liver; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Severity of Illness Index; Treatment Outcome | 2001 |
Homocysteine and folate status in methotrexate-treated patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Daunorubicin; Female; Folic Acid; Genotype; Homocysteine; Humans; Leucovorin; Linear Models; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation | 2002 |
Efficacy and safety of 10-deazaaminopterin in the treatment of rheumatoid arthritis. A one-year continuation, double-blind study.
Topics: Adult; Alkaline Phosphatase; Aminopterin; Arthritis, Rheumatoid; Aspartate Aminotransferases; Double-Blind Method; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged | 1992 |
Homocysteine levels in patients with rheumatoid arthritis treated with low-dose methotrexate.
Topics: Arthritis, Rheumatoid; Cysteine; Double-Blind Method; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate | 1991 |
The effect of folic acid supplementation on the toxicity of low-dose methotrexate in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Folic Acid; Humans; Methotrexate; Patient Dropouts | 1990 |
158 other study(ies) available for folic acid and Rheumatoid Arthritis
| Article | Year |
|---|---|
Variation of homocysteine levels in rheumatoid arthritis patients: relationship to inflammation, cardiovascular risk factors, and methotrexate.
Topics: Adult; Arthritis, Rheumatoid; Cardiovascular Diseases; Creatine; Cross-Sectional Studies; Folic Acid; Heart Disease Risk Factors; Homocysteine; Humans; Inflammation; Male; Methotrexate; Middle Aged; Risk Factors; Vitamin B 12 | 2023 |
Rescuing effect of folates on methotrexate cytotoxicity in human trophoblast cells.
Topics: Arthritis, Rheumatoid; Female; Folic Acid; Humans; Leucovorin; Methotrexate; Trophoblasts | 2022 |
Targeted therapy of rheumatoid arthritis via macrophage repolarization.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Chemistry, Pharmaceutical; Cytokines; Diterpenes; Drug Carriers; Drug Liberation; Epoxy Compounds; Folic Acid; Inflammation Mediators; Lipopolysaccharides; Liposomes; Macrophages; Male; Mice; Phenanthrenes; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells | 2021 |
ROS-mediated liposomal dexamethasone: a new FA-targeted nanoformulation to combat rheumatoid arthritis
Topics: Animals; Arthritis, Rheumatoid; Carrier Proteins; Dexamethasone; Folic Acid; Liposomes; Mice; Reactive Oxygen Species; Tumor Necrosis Factor-alpha | 2021 |
Folate-modified triptolide liposomes target activated macrophages for safe rheumatoid arthritis therapy.
Topics: Arthritis, Rheumatoid; Diterpenes; Epoxy Compounds; Folic Acid; Humans; Liposomes; Macrophages; Phenanthrenes | 2022 |
Methotrexate-loaded folic acid of solid-phase synthesis conjugated gold nanoparticles targeted treatment for rheumatoid arthritis.
Topics: Animals; Arthritis, Rheumatoid; Folic Acid; Gold; Metal Nanoparticles; Methotrexate; Mice; Nanoparticles; Rats; Solid-Phase Synthesis Techniques; Tissue Distribution | 2022 |
Macrophage targeted triptolide micelles capable of cGAS-STING pathway inhibition for rheumatoid arthritis treatment.
Topics: Anti-Inflammatory Agents; Arthritis, Rheumatoid; Cytokines; Dextrans; Diterpenes; Epoxy Compounds; Folic Acid; Humans; Immunosuppressive Agents; Interleukin-6; Macrophages; Micelles; Nucleotidyltransferases; Phenanthrenes; Tumor Necrosis Factor-alpha | 2022 |
Microvesicle-camouflaged biomimetic nanoparticles encapsulating a metal-organic framework for targeted rheumatoid arthritis therapy.
Topics: Arthritis, Rheumatoid; Biomimetics; Folic Acid; Humans; Metal-Organic Frameworks; Methotrexate; Nanoparticles; Tissue Distribution | 2022 |
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Methotrexate; Rheumatic Diseases | 2022 |
Folate in maternal rheumatoid arthritis-filial autism spectrum disorder continuum.
Topics: Arthritis, Rheumatoid; Autism Spectrum Disorder; Child; Female; Folic Acid; Humans; Male; Mothers; Pregnancy; Risk Factors | 2023 |
A Multifunctional Nano-Delivery System Against Rheumatoid Arthritis by Combined Phototherapy, Hypoxia-Activated Chemotherapy, and RNA Interference.
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Hypoxia; Myeloid Cell Leukemia Sequence 1 Protein; Nanoparticle Drug Delivery System; Nanoparticles; Phototherapy; RNA Interference; RNA, Small Interfering; Tirapazamine | 2022 |
Folate receptor-mediated targeted therapy for rheumatoid arthritis by methotrexate-phospholipid complex nano-emulsions.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Macrophages; Methotrexate; Mice; Phospholipids | 2023 |
[Must folic acid and folinic acid be substituted in methotrexate treatment? If yes, how much?]
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Humans; Leucovorin; Methotrexate | 2023 |
Calcium Folate for Reducing the Side Effects of Low-dose Methotrexate in Rheumatoid Arthritis: A Case Report.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Calcium; Folic Acid; Humans; Leucovorin; Male; Methotrexate | 2024 |
Oral liposomes encapsulating ginsenoside compound K for rheumatoid arthritis therapy.
Topics: Animals; Arthritis, Rheumatoid; Drug Delivery Systems; Folic Acid; Ginsenosides; Liposomes; Rats | 2023 |
Imaging Rheumatoid Arthritis in Mice Using Combined Near Infrared and
Topics: Animals; Arthritis, Rheumatoid; Disease Models, Animal; Fluorine-19 Magnetic Resonance Imaging; Folic Acid; Mice; Nanoparticles; RAW 264.7 Cells; Spectroscopy, Near-Infrared | 2019 |
First in man study of [
Topics: Aged; Arthritis, Rheumatoid; Early Diagnosis; Female; Fluorine Radioisotopes; Folate Receptor 2; Folic Acid; Humans; Macrophages; Male; Middle Aged; Molecular Imaging; Polyethylene Glycols; Positron-Emission Tomography; Synovial Membrane | 2020 |
Association of Serum Folate Levels With Cardiovascular Mortality Among Adults With Rheumatoid Arthritis.
Topics: Arthritis, Rheumatoid; Cardiovascular Diseases; Causality; Female; Folic Acid; Homocysteine; Humans; Male; Middle Aged; Proportional Hazards Models; Risk Assessment; United States | 2020 |
Usefulness of daily folic acid supplementation during methotrexate treatment of Japanese patients with rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Dose-Response Relationship, Drug; Drug Monitoring; Female; Folic Acid; Hematinics; Humans; Japan; Male; Methotrexate; Treatment Outcome | 2021 |
Role of folate-conjugated glycol-chitosan nanoparticles in modulating the activated macrophages to ameliorate inflammatory arthritis: in vitro and in vivo activities.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Survival; Chitosan; Drug Liberation; Female; Folic Acid; HEK293 Cells; Humans; MCF-7 Cells; Membrane Potential, Mitochondrial; Methotrexate; Mice; Nanoparticles; Rats, Wistar; RAW 264.7 Cells | 2020 |
Serum homocysteine levels and their association with clinical characteristics of inflammatory arthritis.
Topics: Arthritis, Rheumatoid; Folic Acid; Homocysteine; Humans; Methotrexate; Spondylitis, Ankylosing | 2020 |
Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Biomimetic Materials; Cholesterol; Dexamethasone; Exosomes; Folic Acid; Joints; Male; Mice; Nanoparticles; Polyethylene Glycols; RAW 264.7 Cells | 2020 |
Risk of haematological events and preventive effect of folic acid in methotrexate users with chronic kidney disease and rheumatoid arthritis: Analysis of the Japanese Adverse Drug Event Report database.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug-Related Side Effects and Adverse Reactions; Folic Acid; Humans; Japan; Methotrexate; Renal Insufficiency, Chronic | 2021 |
Perspectives of Methotrexate-Based Radioagents for Application in Nuclear Medicine.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Methotrexate; Nuclear Medicine; Radiopharmaceuticals | 2021 |
Folic acid decorated chitosan-coated solid lipid nanoparticles for the oral treatment of rheumatoid arthritis.
Topics: Administration, Oral; Animals; Arthritis, Rheumatoid; Chitosan; Drug Carriers; Folic Acid; Lipids; Nanoparticles; Rats | 2021 |
Folate-methotrexate loaded bovine serum albumin nanoparticles preparation: an
Topics: Animals; Arthritis, Rheumatoid; Cytokines; Drug Delivery Systems; Folic Acid; Methotrexate; Nanoparticles; Serum Albumin, Bovine | 2023 |
Folate receptor-targeting semiconducting polymer dots hybrid mesoporous silica nanoparticles against rheumatoid arthritis through synergistic photothermal therapy, photodynamic therapy, and chemotherapy.
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Hyperthermia, Induced; Nanoparticles; Photochemotherapy; Phototherapy; Photothermal Therapy; Polymers; Silicon Dioxide | 2021 |
In-vivo monitoring of anti-folate therapy in arthritic rats using [
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Fluorine Radioisotopes; Folic Acid; Male; Methotrexate; Polyethylene Glycols; Positron-Emission Tomography; Rats; Rats, Wistar | 2017 |
Are dietary vitamin D, omega-3 fatty acids and folate associated with treatment results in patients with early rheumatoid arthritis? Data from a Swedish population-based prospective study.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Fatty Acids, Omega-3; Female; Folic Acid; Humans; Male; Middle Aged; Prospective Studies; Sweden; Vitamin D; Vitamins | 2017 |
Multifunctional folate receptor-targeting and pH-responsive nanocarriers loaded with methotrexate for treatment of rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Disease Models, Animal; Drug Carriers; Folate Receptors, GPI-Anchored; Folic Acid; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Male; Methotrexate; Molecular Targeted Therapy; Nanoparticles; Polyesters; Polyethylene Glycols; Polymers; Rats, Sprague-Dawley | 2017 |
Folate-conjugated liposomes target and deliver therapeutics to immune cells in a rat model of rheumatoid arthritis.
Topics: Adjuvants, Immunologic; Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Liberation; Female; Fluorescent Dyes; Folic Acid; Folic Acid Transporters; Inflammation; Liposomes; Macrophages; Molecular Targeted Therapy; Optical Imaging; Particle Size; Rats; Rats, Inbred Lew; Surface Properties | 2017 |
MTRR A66G, RFC1 G80A, and MTHFR C677T and A1298C Polymorphisms and Disease Activity in Mexicans with Rheumatoid Arthritis Treated with Methotrexate.
Topics: Adult; Aged; Alleles; Arthritis, Rheumatoid; Ethnicity; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genotype; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Replication Protein C | 2017 |
Folate-Conjugated Superoxide Dismutase Adsorbed Over Antioxidant Mimicking Nanomatrix Frameworks for Treatment of Rheumatoid Arthritis.
Topics: Adsorption; Animals; Antioxidants; Arthritis, Rheumatoid; Biomimetic Materials; Catalase; Cattle; Delayed-Action Preparations; Drug Delivery Systems; Drug Liberation; Enzyme Stability; Folic Acid; Mice; Nanostructures; Oxidative Stress; RAW 264.7 Cells; Sulfides; Superoxide Dismutase | 2018 |
Does daily folic acid supplementation reduce methotrexate efficacy?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Biological Availability; Dermatologic Agents; Drug Antagonism; Folic Acid; Humans; Methotrexate; Psoriasis | 2017 |
Folate receptor-targeted mixed polysialic acid micelles for combating rheumatoid arthritis: in vitro and in vivo evaluation.
Topics: Animals; Arthritis, Rheumatoid; Biological Availability; Cell Line; Dexamethasone; Drug Carriers; Drug Delivery Systems; Folate Receptors, GPI-Anchored; Folic Acid; Interleukin-6; Male; Mice; Micelles; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Sialic Acids; Tissue Distribution; Tumor Necrosis Factor-alpha | 2018 |
Association of hyperhomocysteinemia with genetic variants in key enzymes of homocysteine metabolism and methotrexate toxicity in rheumatoid arthritis patients.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Thymidylate Synthase; Tunisia; Vitamin B 12 | 2018 |
Dual-functional lipid polymeric hybrid pH-responsive nanoparticles decorated with cell penetrating peptide and folate for therapy against rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arginine; Arthritis, Experimental; Arthritis, Rheumatoid; Cell-Penetrating Peptides; Drug Carriers; Folic Acid; Hydrogen-Ion Concentration; Lactic Acid; Lipids; Male; Methotrexate; Mice; Nanoparticles; Particle Size; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Polymers; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Stearic Acids | 2018 |
Do SNPs in folate pharmacokinetic pathway alter levels of intracellular methotrexate polyglutamates and affect response? A prospective study in Indian patients.
Topics: Adult; Alleles; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Female; Folic Acid; gamma-Glutamyl Hydrolase; Genotype; Humans; India; Logistic Models; Male; Methotrexate; Middle Aged; Odds Ratio; Peptide Synthases; Polyglutamic Acid; Polymorphism, Single Nucleotide; Prospective Studies; Replication Protein C | 2018 |
How should we manage low-dose methotrexate-induced pancytopenia in patients with rheumatoid arthritis?
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disease Management; Female; Folic Acid; Granulocyte Colony-Stimulating Factor; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Pancytopenia; Retrospective Studies; Rheumatology | 2018 |
Combination of NF-kB targeted siRNA and methotrexate in a hybrid nanocarrier towards the effective treatment in rheumatoid arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Calcium Phosphates; Drug Liberation; Folate Receptor 2; Folic Acid; Genetic Therapy; Humans; Liposomes; Methotrexate; Mice; Molecular Targeted Therapy; Nanoparticles; NF-kappa B; Particle Size; Rats; RAW 264.7 Cells; RNA, Small Interfering | 2018 |
Folic Acid-Containing Dietary Supplement Consumption and Risk of Cardiovascular Diseases in Rheumatoid Arthritis Patients: NHANES 1999-2014.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Incidence; Male; Middle Aged; Nutrition Surveys; Retrospective Studies; Risk Assessment; Risk Factors; Survival Rate; United States; Vitamin B Complex | 2019 |
Development and validation of a prognostic multivariable model to predict insufficient clinical response to methotrexate in rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Area Under Curve; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; Cohort Studies; Female; Folic Acid; Humans; Logistic Models; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Proteins; Polymorphism, Single Nucleotide; Predictive Value of Tests; Prognosis; Risk Factors; ROC Curve; Treatment Outcome | 2018 |
The importance of inhibition of a catabolic pathway of methotrexate metabolism in its efficacy for rheumatoid arthritis.
Topics: Animals; Antirheumatic Agents; Arthritis, Rheumatoid; Biological Products; Drug Therapy, Combination; Female; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Male; Methotrexate; Osteoporosis; Purines; Raloxifene Hydrochloride; Rats; Rats, Inbred Lew; Treatment Outcome | 2019 |
Delivery of siRNA using folate receptor-targeted pH-sensitive polymeric nanoparticles for rheumatoid arthritis therapy.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Death; Cytokines; Drug Liberation; Folic Acid; Gene Transfer Techniques; Hemolysis; Hydrogen-Ion Concentration; Joints; Mice; Nanoparticles; Polymers; Rats; RAW 264.7 Cells; RNA, Small Interfering; Tissue Distribution | 2019 |
Folate Conjugated Double Liposomes Bearing Prednisolone and Methotrexate for Targeting Rheumatoid Arthritis.
Topics: Animals; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Drug Compounding; Drug Liberation; Drug Therapy, Combination; Folic Acid; Humans; Liposomes; Male; Methotrexate; Particle Size; Phosphatidylethanolamines; Polyethylene Glycols; Prednisolone; Rats; Surface Properties; Tissue Distribution | 2019 |
Determination of methotrexate and folic acid by ion chromatography with electrochemical detection on a functionalized multi-wall carbon nanotube modified electrode.
Topics: Arthritis, Rheumatoid; Chromatography, Ion Exchange; Electrochemical Techniques; Electrodes; Folic Acid; Humans; Limit of Detection; Linear Models; Methotrexate; Nanotubes, Carbon; Reproducibility of Results | 2013 |
Oral mucositis in patients receiving low-dose methotrexate therapy for rheumatoid arthritis: report of 2 cases and literature review.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Diagnosis, Differential; Drug Overdose; Female; Folic Acid; Follow-Up Studies; Gingivitis, Necrotizing Ulcerative; Hospitalization; Humans; Lip Diseases; Methotrexate; Oral Ulcer; Skin Ulcer; Stomatitis; Stomatitis, Herpetic; Tongue Diseases | 2013 |
Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Enzymes; Female; Folate Receptor 1; Folate Receptor 2; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Multidrug Resistance-Associated Protein 2; Proton-Coupled Folate Transporter; Reduced Folate Carrier Protein; Transcriptome; Up-Regulation | 2013 |
Drug therapy. Methotrexate normalizes folate pathway genes in RA.
Topics: Arthritis, Rheumatoid; Female; Folic Acid; Humans; Male; Methotrexate; Transcriptome | 2013 |
Folic acid supplementation for rheumatoid arthritis patients on methotrexate: the good gets better.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Methotrexate | 2013 |
Folate-conjugated albumin nanoparticles for rheumatoid arthritis-targeted delivery of etoricoxib.
Topics: Animals; Arthritis, Rheumatoid; Cattle; Drug Delivery Systems; Etoricoxib; Folic Acid; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Pyridines; Serum Albumin, Bovine; Sulfones | 2015 |
SLC19A1 80G allele as a biomarker of methotrexate-related gastrointestinal toxicity in Portuguese rheumatoid arthritis patients.
Topics: Adult; Aged; Aged, 80 and over; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Biomarkers; Female; Folic Acid; Gastrointestinal Tract; Genotype; Humans; Male; Methotrexate; Middle Aged; Portugal; Reduced Folate Carrier Protein; Retrospective Studies | 2014 |
Perceptions of methotrexate use in rheumatoid arthritis by rheumatologists and their patients: an Australian survey study.
Topics: Aged; Alcohol Drinking; Antirheumatic Agents; Arthritis, Rheumatoid; Attitude of Health Personnel; Australia; Biological Products; Drug Therapy, Combination; Female; Folic Acid; Health Care Surveys; Health Knowledge, Attitudes, Practice; Humans; Male; Methotrexate; Middle Aged; Patient Preference; Patients; Perception; Physicians; Rheumatology; Surveys and Questionnaires; Treatment Outcome | 2013 |
Detection of bone erosions in early rheumatoid arthritis: 3D ultrasonography versus computed tomography.
Topics: Adult; Arthritis, Rheumatoid; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Hand; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Male; Methotrexate; Middle Aged; Predictive Value of Tests; Prospective Studies; Sensitivity and Specificity; Synovitis; Tomography, X-Ray Computed; Ultrasonography; Wrist Joint | 2015 |
Antiinflammatory Activity of a Novel Folic Acid Targeted Conjugate of the mTOR Inhibitor Everolimus.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Proliferation; Everolimus; Folate Receptor 2; Folic Acid; Humans; Inflammation; Rats; Signal Transduction; TOR Serine-Threonine Kinases | 2015 |
Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice.
Topics: Animals; Arthritis, Rheumatoid; Cell Line; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation; Humans; Liposomes; Macrophages; Male; Methotrexate; Mice | 2015 |
Folate metabolic pathway single nucleotide polymorphisms: a predictive pharmacogenetic marker of methotrexate response in Indian (Asian) patients with rheumatoid arthritis.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Asian People; Cross-Sectional Studies; Female; Folic Acid; Genotype; Humans; Male; Metabolic Networks and Pathways; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Risk | 2015 |
Factors Associated with Myelosuppression Related to Low-Dose Methotrexate Therapy for Inflammatory Rheumatic Diseases.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Case-Control Studies; Female; Folic Acid; Hematologic Diseases; Humans; Hypoalbuminemia; Male; Methotrexate; Middle Aged; Neutropenia; Pancytopenia; Retrospective Studies; Rheumatic Diseases; Risk Factors; Serum Albumin | 2016 |
Optimization of Folate-Targeted Immunotherapy for the Treatment of Experimental Arthritis.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Folic Acid; Haptens; Immunoconjugates; Immunotherapy; Macrophages; Molecular Targeted Therapy; Receptors, Cell Surface | 2016 |
Severe acute pancytopaenia in a patient with rheumatoid arthritis complicated by fatal invasive pulmonary aspergillosis.
Topics: Acute Disease; Adrenal Cortex Hormones; Arthritis, Rheumatoid; Fatal Outcome; Female; Folic Acid; Humans; Immunosuppressive Agents; Invasive Pulmonary Aspergillosis; Methotrexate; Middle Aged; Pancytopenia; Severity of Illness Index; Vitamin B Complex | 2017 |
Real-world experiences of folic acid supplementation (5 versus 30 mg/week) with methotrexate in rheumatoid arthritis patients: a comparison study.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Cross-Sectional Studies; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Folic Acid; Humans; Malaysia; Male; Methotrexate; Middle Aged; Surveys and Questionnaires; Treatment Outcome; Vitamin B Complex | 2016 |
Macrophages mediated diagnosis of rheumatoid arthritis using fibrin based magnetic nanoparticles as MRI contrast agents.
Topics: Animals; Arthritis, Rheumatoid; Contrast Media; Endocytosis; Fibrin; Folic Acid; Goats; Hydrodynamics; Liver; Macrophages; Magnetic Resonance Imaging; Magnetite Nanoparticles; Male; Mice; Powders; Rats, Wistar; RAW 264.7 Cells; Spectrophotometry, Ultraviolet; Spectroscopy, Fourier Transform Infrared; Staining and Labeling; Static Electricity; X-Ray Diffraction | 2017 |
Folic Acid Supplementation Is Suboptimal in a National Cohort of Older Veterans Receiving Low Dose Oral Methotrexate.
Topics: Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Administration Schedule; Female; Folic Acid; Humans; Male; Methotrexate; Retrospective Studies; Veterans | 2016 |
Genetic determinants of methotrexate toxicity in rheumatoid arthritis patients: a study of polymorphisms affecting methotrexate transport and folate metabolism.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Female; Ferredoxin-NADP Reductase; Folic Acid; Humans; Male; Membrane Transport Proteins; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Thymidylate Synthase | 2008 |
Folic acid supplements are good (not bad) for rheumatoid arthritis patients treated with low-dose methotrexate.
Topics: Arthritis, Rheumatoid; Drug Interactions; Folic Acid; Food, Fortified; Humans; Methotrexate; Treatment Outcome | 2008 |
[Is the guideline, "Management of early rheumatoid arthritis," being followed in a rheumatism center?].
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Rheumatoid; Calcium; Drug Therapy, Combination; Folic Acid; Germany; Glucocorticoids; Guideline Adherence; Hospitals, Special; Humans; Methotrexate; Rheumatology; Vitamin B Complex; Vitamin D; Vitamins | 2008 |
[Megaloblastic anemia associated with salazosulfapyridine treatment for rheumatoid arthritis].
Topics: Aged; Anemia, Megaloblastic; Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Folic Acid Deficiency; Humans; Male; Prednisolone; Sulfasalazine; Treatment Outcome | 2008 |
Gynecomastia associated with low-dose methotrexate therapy for rheumatoid arthritis ameliorated by folate supplement.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Dose-Response Relationship, Drug; Folic Acid; Gynecomastia; Humans; Male; Mammography; Methotrexate; Middle Aged; Tomography, X-Ray Computed; Treatment Outcome; Vitamin B Complex | 2010 |
Methotrexate catabolism to 7-hydroxymethotrexate in rheumatoid arthritis alters drug efficacy and retention and is reduced by folic acid supplementation.
Topics: Aldehyde Oxidase; Arthritis, Rheumatoid; Chromatography, High Pressure Liquid; Folic Acid; Health Status; Humans; Joints; Leucovorin; Methotrexate; Pain; Tandem Mass Spectrometry; Treatment Outcome | 2009 |
[Correct use of methotrexate].
Topics: Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Psoriasis; Treatment Outcome | 2009 |
Gene-gene interactions in folate and adenosine biosynthesis pathways affect methotrexate efficacy and tolerability in rheumatoid arthritis.
Topics: Adenosine; Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Biosynthetic Pathways; Epistasis, Genetic; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide | 2009 |
The use of folic acid in the treatment of anemia of rheumatoid arthritis: a preliminary report.
Topics: Anemia; Aortic Aneurysm; Arthritis; Arthritis, Rheumatoid; Folic Acid; Humans | 1947 |
Polymorphisms within the folate pathway predict folate concentrations but are not associated with disease activity in rheumatoid arthritis patients on methotrexate.
Topics: AMP Deaminase; Arthritis, Rheumatoid; Erythrocytes; Ferredoxin-NADP Reductase; Folic Acid; Genome-Wide Association Study; Glycine Hydroxymethyltransferase; Humans; Longitudinal Studies; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Multidrug Resistance-Associated Protein 2; Polyglutamic Acid; Polymorphism, Genetic | 2010 |
[Unilateral odynophagia in rheumatoid arthritis].
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cooperative Behavior; Deglutition Disorders; Diagnosis, Differential; Diclofenac; Drug Therapy, Combination; Dysphonia; Endoscopy; Female; Folic Acid; Humans; Interdisciplinary Communication; Lymphopenia; Methotrexate; Middle Aged; Misoprostol; Opportunistic Infections; Oral Ulcer; Pain; Pharyngitis; Prednisolone | 2011 |
Evidence of the symptomatic and structural efficacy of methotrexate in daily practice as the first disease-modifying drug in rheumatoid arthritis despite its suboptimal use: results from the ESPOIR early synovitis cohort.
Topics: Adolescent; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Disease Progression; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Folic Acid; Health Status; Humans; Male; Methotrexate; Middle Aged; Outcome Assessment, Health Care; Severity of Illness Index; Synovitis; Treatment Outcome; Young Adult | 2012 |
A dancer with rheumatoid arthritis: a role for biologics.
Topics: Arthritis, Rheumatoid; Biological Products; Dancing; Drug Therapy, Combination; Female; Folic Acid; Humans; Hydroxychloroquine; Methotrexate; Treatment Outcome; Young Adult | 2013 |
Folic acid and folinic acid supplementation during low-dose methotrexate therapy for rheumatoid arthritis: comment on the article by van Ede et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Hematinics; Humans; Leucovorin; Methotrexate | 2002 |
In utero first trimester exposure to low-dose methotrexate with increased fetal nuchal translucency and associated malformations.
Topics: Abnormalities, Drug-Induced; Adult; Arthritis, Rheumatoid; Female; Folic Acid; Gestational Age; Heart Septal Defects; Hernia, Diaphragmatic; Humans; Methotrexate; Neck; Pregnancy; Pregnancy Complications; Ultrasonography, Prenatal | 2002 |
Hyperhomocysteinemia in rheumatoid arthritis: influence of methotrexate treatment and folic acid supplementation.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Disability Evaluation; Drug Therapy, Combination; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Health Status; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methotrexate; Middle Aged; Surveys and Questionnaires; Treatment Outcome | 2002 |
Methotrexate treatment and mortality in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Drug Therapy, Combination; Folic Acid; Humans; Methotrexate; Research Design; Survival Analysis | 2002 |
Purine enzymes in patients with rheumatoid arthritis treated with methotrexate.
Topics: Adenosine Deaminase; Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Blood Sedimentation; Female; Folic Acid; Humans; Hypoxanthine Phosphoribosyltransferase; Leucovorin; Male; Methotrexate; Middle Aged; Nucleotidases; Purine-Nucleoside Phosphorylase; Purines; Regression Analysis | 2002 |
[The effect of comedication with folic or folinic acid on the toxicity and efficacy of methotrexate in rheumatoid arthritis: a randomized, double blind, placebo controlled study of 48 weeks].
Topics: Alcohol Drinking; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Humans; Leucovorin; Methotrexate | 2002 |
Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Cells, Cultured; Cytokines; Dose-Response Relationship, Immunologic; Folic Acid; Humans; Immunosuppressive Agents; Lymphocyte Activation; Methotrexate; Monocytes; T-Lymphocytes | 2003 |
Myelotoxicity due to methotrexate - an iatrogenic cause.
Topics: Aged; Anti-Infective Agents, Urinary; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Female; Folic Acid; Humans; Iatrogenic Disease; Methotrexate; Middle Aged; Trimethoprim | 2003 |
FOLIC-ACID DEFICIENCY IN RHEUMATOID ARTHRITIS.
Topics: Anemia; Anemia, Macrocytic; Arthritis, Rheumatoid; Folic Acid; Folic Acid Deficiency; Humans; Vitamin B Deficiency | 1964 |
HEMATOLOGICAL COMPLICATIONS OF PHENYLBUTAZONE THERAPY: REVIEW OF THE LITERATURE AND REPORT OF TWO CASES.
Topics: Adrenocorticotropic Hormone; Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Arthritis; Arthritis, Rheumatoid; Blood Platelet Disorders; Blood Transfusion; Folic Acid; Hematology; Humans; Leukemia; Leukocyte Count; Leukopenia; Phenylbutazone; Prednisolone; Thrombocytopenia; Toxicology | 1964 |
SIDEROBLASTIC ANAEMIA IN MAN: OBSERVATIONS ON SEVENTY CASES.
Topics: Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Sideroblastic; Arthritis; Arthritis, Rheumatoid; Bone Marrow Examination; Diagnosis, Differential; Drug Therapy; Elliptocytosis, Hereditary; Folic Acid; Folic Acid Deficiency; Humans; Leukemia; Malabsorption Syndromes; Pathology; Polycythemia Vera; Spherocytosis, Hereditary; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 1965 |
Longterm observational study of methotrexate use in a Dutch cohort of 1022 patients with rheumatoid arthritis.
Topics: Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Cohort Studies; Drug Therapy, Combination; Female; Folic Acid; Humans; Life Tables; Longitudinal Studies; Male; Methotrexate; Middle Aged; Multivariate Analysis; Physicians; Prednisolone; Proportional Hazards Models; Retrospective Studies; Rheumatology; Sulfasalazine; Survival Analysis | 2003 |
Sulfasalazine is a potent inhibitor of the reduced folate carrier: implications for combination therapies with methotrexate in rheumatoid arthritis.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cell Line; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Drug Therapy, Combination; Folic Acid; Humans; Leucovorin; Membrane Transport Modulators; Membrane Transport Proteins; Methotrexate; Reduced Folate Carrier Protein; Sulfasalazine | 2004 |
Methotrexate and folic acid: what is the optimal combination?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Folic Acid; Humans; Methotrexate | 2004 |
Acute erythroleukemia in a rheumatoid arthritis patient during low-dose methotrexate therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Folic Acid; Humans; Hydroxychloroquine; Leukemia, Erythroblastic, Acute; Methotrexate; Treatment Outcome | 2005 |
Risk factors for methotrexate-induced abnormal laboratory monitoring results in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Cohort Studies; Female; Folic Acid; Humans; Hyperlipidemias; Incidence; Liver Cirrhosis; Male; Methotrexate; Middle Aged; Retrospective Studies; Risk Factors | 2004 |
Methotrexate related adverse effects in patients with rheumatoid arthritis are associated with the A1298C polymorphism of the MTHFR gene.
Topics: Adult; Aged; Alleles; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Female; Folic Acid; Genotype; Homocysteine; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic | 2004 |
Folate, homocysteine, and cobalamin status in patients with rheumatoid arthritis treated with methotrexate, and the effect of low dose folic acid supplement.
Topics: Arthritis, Rheumatoid; Biomarkers; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Follow-Up Studies; Homocysteine; Humans; Male; Methotrexate; Probability; Prospective Studies; Risk Assessment; Sensitivity and Specificity; Severity of Illness Index; Single-Blind Method; Treatment Outcome; Vitamin B 12 | 2004 |
Intermittent rises in plasma homocysteine in patients with rheumatoid arthritis treated with higher dose methotrexate.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Middle Aged | 2005 |
Influence of serum folic acid levels on plasma homocysteine concentrations in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Immunosuppressive Agents; Methotrexate; Middle Aged; Statistics, Nonparametric; Vitamin B 12; Vitamin B Complex | 2006 |
Folic acid supplementation during methotrexate treatment: nonsense?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Administration Schedule; Folic Acid; Gastritis, Atrophic; Humans; Methotrexate | 2005 |
Folic acid and folinic acid supplements and methotrexate therapy: comment on the article by Morgan et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Drug Antagonism; Folic Acid; Folic Acid Deficiency; Humans; Leucovorin; Methotrexate; Purines | 2005 |
Reversible optic neuropathy associated with low-dose methotrexate therapy.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Color Vision Defects; Evoked Potentials, Visual; Female; Folic Acid; Humans; Methotrexate; Optic Nerve Diseases; Scotoma; Visual Fields | 2005 |
Risk genotypes in folate-dependent enzymes and their association with methotrexate-related side effects in rheumatoid arthritis.
Topics: Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Cross-Sectional Studies; Enzymes; Female; Folic Acid; Genetic Markers; Genotype; Glycine Hydroxymethyltransferase; Humans; Hydroxymethyl and Formyl Transferases; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multienzyme Complexes; Nucleotide Deaminases; Odds Ratio; Thymidylate Synthase | 2006 |
I've taken methotrexate for several months to control my rheumatoid arthritis, but the bouts of upset stomach have become too much. I read that folic acid can counteract the side effects of methotrexate. Can you tell me more about it?
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Folic Acid; Humans; Methotrexate; Stomach Diseases | 2006 |
Effect of folic acid supplementation on the efficacy of methotrexate treatment in rheumatoid arthritis: comment on the article by Khanna et al.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Folic Acid; Hematinics; Humans; Methotrexate | 2006 |
Correlation between methotrexate efficacy & toxicity with C677T polymorphism of the methylenetetrahydrofolate gene in rheumatoid arthritis patients on folate supplementation.
Topics: Adult; Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid; Humans; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic | 2006 |
Methods to enhance the safety of methotrexate prescribing.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Drug Labeling; Drug Packaging; Drug Therapy, Combination; Folic Acid; Humans; Medication Errors; Methotrexate; Polymyositis; Practice Patterns, Physicians'; Vitamin B Complex | 2007 |
Preliminary evidence shows that folic acid fortification of the food supply is associated with higher methotrexate dosing in patients with rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Dose-Response Relationship, Drug; Drug Interactions; Female; Folic Acid; Food Supply; Food, Fortified; Humans; Male; Methotrexate; Middle Aged; Retrospective Studies | 2007 |
Elevated plasma homocysteine and low vitamin B-6 status in nonsupplementing older women with rheumatoid arthritis.
Topics: Aged; Arthritis, Rheumatoid; C-Reactive Protein; Cardiovascular Diseases; Case-Control Studies; Cross-Sectional Studies; Diet Records; Erythrocytes; Female; Folic Acid; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Middle Aged; Nutritional Status; Pyridoxal Phosphate; Risk Factors; Transcobalamins; Vitamin B 12; Vitamin B 6; Vitamin B 6 Deficiency; Vitamin B Complex | 2008 |
Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Folic Acid; Gene Frequency; Genotype; Haplotypes; Health Status; Humans; Hydroxychloroquine; Male; Methotrexate; Middle Aged; Polymorphism, Single Nucleotide; Predictive Value of Tests; Severity of Illness Index; Sulfasalazine; Tetrahydrofolate Dehydrogenase | 2008 |
Radioisotope binding capacity of serum in folic acid, vitamin B12 and ferritin in haematologic and rheumatologic patients.
Topics: Adult; Aged; Anemia, Hypochromic; Arthritis, Rheumatoid; Female; Ferritins; Folic Acid; Hematologic Tests; Humans; Male; Middle Aged; Radioisotopes; Spondylitis, Ankylosing; Vitamin B 12 | 1980 |
Folic acid and methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Drug Tolerance; Folic Acid; Humans; Methotrexate; Treatment Outcome | 1996 |
Folic acid and methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Tolerance; Erythrocyte Indices; Folic Acid; Humans; Methotrexate | 1996 |
Folic acid and methotrexate in rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Drug Tolerance; Folic Acid; Humans; Methotrexate; Treatment Outcome | 1996 |
An audit of methotrexate and folic acid for rheumatoid arthritis. Experience from a teaching centre.
Topics: Adult; Aged; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Monitoring; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Medical Audit; Methotrexate; Middle Aged; Patient Satisfaction; Prospective Studies; Severity of Illness Index; Treatment Outcome | 1995 |
Methotrexate for chronic diseases in adults.
Topics: Adult; Arthritis, Rheumatoid; Chronic Disease; Folic Acid; Humans; Methotrexate; Vitamin B 12 Deficiency | 1995 |
Abnormal vitamin B6 status in rheumatoid cachexia. Association with spontaneous tumor necrosis factor alpha production and markers of inflammation.
Topics: Adult; Aged; Arthritis, Rheumatoid; Cachexia; Cross-Sectional Studies; Diet; Endotoxins; Female; Folic Acid; Humans; Male; Middle Aged; Pyridoxal Phosphate; Pyridoxine; Tumor Necrosis Factor-alpha; Vitamin B 12 | 1995 |
Leucovorin versus folic acid in the treatment of methotrexate toxicity: comment on the article by Shiroky et al.
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Leucovorin; Methotrexate | 1994 |
Folic acid supplementation during methotrexate therapy: it makes sense.
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Humans; Leucovorin; Methotrexate | 1993 |
Pancytopenia associated with low dose methotrexate therapy. A regional survey.
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Arthritis, Psoriatic; Arthritis, Rheumatoid; Blood Urea Nitrogen; Canada; Creatinine; Dose-Response Relationship, Drug; Female; Folic Acid; Health Surveys; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Pancytopenia; Psoriasis; Risk Factors; Surveys and Questionnaires; Trimethoprim, Sulfamethoxazole Drug Combination | 1993 |
Folate supplementation and methotrexate.
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Immune Tolerance; Methotrexate | 1993 |
DNA hypomethylation in inflammatory arthritis: reversal with methotrexate.
Topics: Adult; Antirheumatic Agents; Arthritis, Psoriatic; Arthritis, Rheumatoid; DNA Methylation; Female; Folic Acid; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Vitamin B 12 | 1996 |
Folate and homocysteine status and haemolysis in patients treated with sulphasalazine for arthritis.
Topics: Adolescent; Adult; Aged; Arthritis; Arthritis, Rheumatoid; Colitis, Ulcerative; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Hemolysis; Homocysteine; Humans; Male; Spondylitis, Ankylosing; Sulfasalazine | 1996 |
[Pancytopenia in rheumatoid arthritis treated with methotrexate].
Topics: Aged; Arthritis, Rheumatoid; Female; Folic Acid; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; Pancytopenia; Retrospective Studies; Risk Factors | 1996 |
Use of methotrexate in older patients. A risk-benefit assessment.
Topics: Aged; Aging; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions; Drug Monitoring; Drug Therapy, Combination; Folic Acid; Humans; Methotrexate; Risk Assessment | 1996 |
Guidelines for folate supplementation in rheumatoid arthritis patients treated with methotrexate: comment on the guidelines for monitoring drug therapy.
Topics: Arthritis, Rheumatoid; Folic Acid; Food, Fortified; Humans; Practice Guidelines as Topic | 1997 |
Folic acid supplementation prevents deficient blood.
Topics: Arthritis, Rheumatoid; Dietary Supplements; Folic Acid; Folic Acid Deficiency; Hematinics; Humans | 1998 |
Increased plasma levels of homocysteine and other thiol compounds in rheumatoid arthritis women.
Topics: Adult; Amino Acids; Arthritis, Rheumatoid; Cysteine; Female; Folic Acid; Glutathione; Glycine; Homocysteine; Humans; Middle Aged; Vitamin B 12 | 1999 |
Selective expression of folate receptor beta and its possible role in methotrexate transport in synovial macrophages from patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Lipopolysaccharide Receptors; Methotrexate; Monocytes; Receptors, Cell Surface; RNA; Synovial Membrane | 1999 |
Elevation of serum hepatic aminotransferases during treatment of rheumatoid arthritis with low-dose methotrexate. Risk factors and response to folic acid.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Aspartate Aminotransferases; Female; Folic Acid; Histamine H2 Antagonists; Humans; Liver; Male; Medical Records; Methotrexate; Middle Aged; Retrospective Studies | 1999 |
Toxicity profile of methotrexate in rheumatoid arthritis. A preliminary survey.
Topics: Adult; Aged; Anemia, Macrocytic; Antirheumatic Agents; Arthritis, Rheumatoid; Exanthema; Female; Folic Acid; Gastrointestinal Diseases; Health Care Surveys; Humans; Liver; Liver Function Tests; Male; Methotrexate; Middle Aged; Pancytopenia; Patient Education as Topic; Patient Selection; Risk Factors | 1999 |
Folic acid supplementation and methotrexate efficacy: comment on articles by Schiff, Emery et al, and others.
Topics: Arthritis, Rheumatoid; Dietary Supplements; Folic Acid; Humans; Methotrexate; Therapeutic Equivalency | 2000 |
[Methotrexate].
Topics: Arthritis, Rheumatoid; Drug Therapy, Combination; Folic Acid; Humans; Leucovorin; Methotrexate | 2001 |
Homocysteine modulation as a reason for continuous folic acid supplementation in methotrexate-treated rheumatoid arthritis patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Dietary Supplements; Folic Acid; Homocysteine; Humans; Methotrexate; Myocardial Ischemia | 2001 |
Changes in plasma homocysteine in arthritis patients starting treatment with low-dose methotrexate subsequently supplemented with folic acid.
Topics: Adult; Aged; Aged, 80 and over; Antirheumatic Agents; Arthritis, Rheumatoid; Cardiovascular Diseases; Drug Therapy, Combination; Female; Folic Acid; Hematinics; Homocysteine; Humans; Male; Methotrexate; Middle Aged; Risk Factors | 2001 |
Serum folates in man.
Topics: Anemia, Pernicious; Arthritis, Rheumatoid; Biological Assay; Celiac Disease; Enterococcus faecalis; Folic Acid; Formyltetrahydrofolates; Humans; Lacticaseibacillus casei; Leukemia; Pediococcus; Schizophrenia; Tetrahydrofolates | 1977 |
Serum pyridoxal in patients with rheumatoid arthritis.
Topics: Adolescent; Adult; Age Factors; Aged; Arthritis, Rheumatoid; Female; Folic Acid; Humans; Male; Middle Aged; Osteoarthritis; Pyridoxal; Sex Factors | 1976 |
Inhibition of folate-dependent enzymes by non-steroidal anti-inflammatory drugs.
Topics: Acyltransferases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Rheumatoid; Cattle; Cells, Cultured; Folic Acid; Folic Acid Antagonists; Formates; Humans; Hydroxymethyl and Formyl Transferases; Kinetics; Liver; Molecular Structure; Monocytes; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Structure-Activity Relationship | 1992 |
Local infectious complications following large joint replacement in rheumatoid arthritis patients treated with methotrexate versus those not treated with methotrexate.
Topics: Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Folic Acid; Humans; Incidence; Knee Prosthesis; Male; Methotrexate; Middle Aged; Prednisone; Reoperation; Retrospective Studies; Surgical Wound Dehiscence; Surgical Wound Infection | 1991 |
Folate supplementation in methotrexate-treated rheumatoid arthritis patients.
Topics: Arthritis, Rheumatoid; Blood Cell Count; Creatinine; Drug Therapy, Combination; Folic Acid; Gastrointestinal Diseases; Humans; Methotrexate | 1991 |
Methotrexate therapy in rheumatoid arthritis patients diminishes lectin-induced mononuclear cell proliferation.
Topics: Arthritis, Rheumatoid; Cell Division; Cells, Cultured; Culture Media; Deoxyuridine; DNA; Female; Folic Acid; Humans; Lectins; Leukocytes, Mononuclear; Male; Methotrexate; Middle Aged; Phytohemagglutinins; Thymidine; Tritium | 1990 |
Comment on the article by Morgan et al.
Topics: Arthritis, Rheumatoid; Folic Acid; Humans; Methotrexate | 1990 |
Methotrexate metabolism analysis in blood and liver of rheumatoid arthritis patients. Association with hepatic folate deficiency and formation of polyglutamates.
Topics: Arthritis, Rheumatoid; Biopsy; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Liver; Methotrexate; Osmolar Concentration; Peptide Biosynthesis; Polyglutamic Acid | 1986 |
Folic acid treatment in methotrexate-treated rheumatoid arthritis patients: comment on the article by Furst and Kremer.
Topics: Adult; Arthritis, Rheumatoid; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Methotrexate; Middle Aged | 1989 |
Folate status of rheumatoid arthritis patients receiving long-term, low-dose methotrexate therapy.
Topics: Adult; Arthritis, Rheumatoid; Diet; Erythrocytes; Female; Folic Acid; Humans; In Vitro Techniques; Leucovorin; Lymphocytes; Male; Methotrexate; Middle Aged; Serine; Vitamins | 1987 |
Serum folic acid in patients with rheumatoid arthritis.
Topics: Arthritis, Rheumatoid; Erythrocyte Count; Female; Folic Acid; gamma-Globulins; Humans; Male; Spondylitis, Ankylosing | 1969 |
[Clinical observations on a new preparation with hepatoprotective action].
Topics: Adult; Aged; Amino Acids; Arthritis, Rheumatoid; Biliary Dyskinesia; Dyspepsia; Female; Folic Acid; Gallbladder Diseases; Gastritis; Humans; Liver Diseases; Male; Middle Aged; Niacinamide; Vitamin B 12 | 1967 |
Nature of anaemia in rheumatoid arthritis. IX. Folate metabolism in patients with rheumatoid arthritis.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Anemia, Macrocytic; Arthritis, Rheumatoid; Bone Marrow Diseases; Erythrocytes; Female; FIGLU Test; Folic Acid; Folic Acid Deficiency; Histidine; Humans; Male; Middle Aged | 1968 |
Proceedings: Pharmacokinetics of folates in the rat and man.
Topics: Animals; Arthritis, Rheumatoid; Brain Chemistry; Celiac Disease; Crohn Disease; Folic Acid; Humans; Intestines; Kidney; Kinetics; Leukemia; Liver; Rats; Tetrahydrofolates | 1974 |
Rheumatoid arthritis with anaemia and thrombocytopenia.
Topics: Adult; Anemia, Macrocytic; Arthritis, Rheumatoid; Blood Transfusion; Folic Acid; Humans; Male; Thrombocytopenia; Vitamin B 12 | 1972 |
Gastric secretory and serologic studies on patients with neoplastic and immunologic disorders.
Topics: Adult; Anemia, Pernicious; Antibody Formation; Arthritis, Rheumatoid; Autoantibodies; Female; Fluorescent Antibody Technique; Folic Acid; Gastric Juice; Hemagglutination Tests; Hodgkin Disease; Humans; Immunodiffusion; Intrinsic Factor; Leukemia, Lymphoid; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Male; Middle Aged; Multiple Myeloma; Pyrazoles; Radioimmunoassay; Vitamin B 12 | 1971 |
Toxicity of trimethoprim-sulphamethoxazole in patients with megaloblastic haemopoiesis.
Topics: Adult; Aged; Agranulocytosis; Anemia, Macrocytic; Anemia, Pernicious; Anti-Infective Agents; Arthritis, Rheumatoid; Blood Platelets; Erythrocyte Count; Female; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Humans; Middle Aged; Pyrimidines; Reticulocytes; Sulfamethoxazole; Tetrahydrofolate Dehydrogenase; Trimethoprim; Vitamin B 12; Vitamin B 12 Deficiency | 1972 |
Malabsorption in rheumatoid disease.
Topics: Alanine Transaminase; Alkaline Phosphatase; Arthritis, Rheumatoid; Aspartate Aminotransferases; Celiac Disease; Cholesterol; Fats; Feces; Folic Acid; Humans; Kidney Diseases; Liver Function Tests; Malabsorption Syndromes; Nucleotidases; Rheumatic Diseases; Serum Albumin; Sulfobromophthalein; Vitamin B 12; Xylose | 1971 |
A haematological study of 500 elderly females.
Topics: Age Factors; Aged; Anemia; Anemia, Hypochromic; Arthritis, Rheumatoid; Blood Chemical Analysis; Blood Proteins; Blood Sedimentation; Bronchitis; England; Feces; Female; Folic Acid; Folic Acid Deficiency; Health Surveys; Hematologic Diseases; Hemoglobins; Hospitalization; Humans; Iron; Middle Aged; Neoplasms; Sex Factors; Vitamin B 12; Vitamin B 12 Deficiency | 1970 |
Metabolic studies of folic acid in non-malignant diseases.
Topics: Acute Disease; Adult; Aged; Arthritis, Rheumatoid; Cholesterol; Chronic Disease; Cooking; Folic Acid; Food; Fractures, Bone; Humans; Hyperthyroidism; Iron; Middle Aged; Myocardial Infarction; Tuberculosis, Pulmonary | 1970 |
Values of serum iron in patients over sixty.
Topics: Aged; Anemia, Hypochromic; Anemia, Pernicious; Arthritis, Rheumatoid; Circadian Rhythm; Dementia; Female; Femoral Fractures; Folic Acid; Hemoglobins; Humans; Iron; Male; Urea; Vitamin B 12; Wales | 1971 |
Interrelationship of rheumatoid arthritis, folic acid, and aspirin.
Topics: Absorption; Arthritis, Rheumatoid; Aspirin; Dialysis; Erythrocytes; FIGLU Test; Folic Acid; Folic Acid Deficiency; Humans; Intestinal Absorption; Lactobacillus; Protein Binding; Tritium | 1971 |
Nature of anaemia in rheumatoid arthritis. X. Folate-releasing properties of plasma in health and disease, with special reference to rheumatoid arthritis.
Topics: Anemia, Macrocytic; Arthritis, Rheumatoid; Erythrocytes; Folic Acid; Folic Acid Deficiency; Humans; Plasma; Vitamin B 12 Deficiency | 1969 |
Fatal dislocation of cervical spine in rheumatoid disease.
Topics: Aged; Arthritis, Rheumatoid; Cervical Vertebrae; Female; Folic Acid; Humans; Joint Dislocations; Osteoporosis; Radiography | 1969 |
Folic-acid deficiency in rheumatoid arthritis: relation of levels of serum folic-acid activity to treatment with phenylbutazone.
Topics: Anemia, Macrocytic; Arthritis, Rheumatoid; Blood; Female; Folic Acid; Folic Acid Deficiency; Humans; Male; Oxyphenbutazone; Phenylbutazone; Vitamin B 12 | 1966 |
Folic acid activity of serum in rheumatoid arthritis.
Topics: Adolescent; Adult; Arthritis, Rheumatoid; Blood; Female; Folic Acid; Humans; In Vitro Techniques; Male; Middle Aged | 1966 |