folic acid has been researched along with Leukemia in 194 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 157 (80.93) | 18.7374 |
1990's | 10 (5.15) | 18.2507 |
2000's | 13 (6.70) | 29.6817 |
2010's | 12 (6.19) | 24.3611 |
2020's | 2 (1.03) | 2.80 |
Authors | Studies |
---|---|
Beardsley, GP; Fletcher, SR; Harrington, PJ; Moran, RG; Taylor, EC | 1 |
Cui, B; Hou, X; Liu, N; Qiu, A; Zhuang, S | 1 |
Kanarek, N; Petrova, B | 1 |
Chen, Y; Geng, R; Hu, X; Huang, T; Kang, Y; Liu, X; Ma, Y; Qi, X; Sun, J; Wan, Q; Wu, YZ; Xu, X; Zeng, X; Zhang, G; Zhao, X | 1 |
Chen, YC; Kataoka, K; Kempter, S; Kessel, E; Lee, DJ; Lehto, T; Liu, X; Padari, K; Pooga, M; Rädler, JO; Sheu, MT; Uchida, S; Wagner, E; Yoshinaga, N | 1 |
Bradner, JE; Ferrando, AA; Kitara, S; Kung, AL; Qi, J; Roti, G; Sanchez-Martin, M; Saur Conway, A; Stegmaier, K; Su, A; Varca, AC; Wu, L | 1 |
Chen, J; Davoudi, Z; Li, D; Liao, J; Wang, Q; Wei, X; Xiong, J; Xiong, X; Yin, Y; Yu, X; Zheng, H | 1 |
Abdeen, S; Alexander, P; Bhagat, M; Chavali, M; Praseetha, PK; Rose, PA | 1 |
Chen, X; Chen, Y; Li, S; Ping, Q; Shi, Y; Su, Z; Sun, M; Xiao, Y; Zong, L | 1 |
Holman, CD; Jin, J; Liu, P; Zhang, M | 1 |
Holman, CD; Jin, J; Liu, P; Xie, X; Zhang, M | 1 |
Cachia, D; Chi, L; Cykowski, MD; Dabaja, BS; Daver, N; Dinardo, C; Fuller, G; Garg, N; Jabbour, EJ; Jain, N; Kadia, TM; Kamiya-Matsuoka, C; Kantarjian, HM; Konopleva, M; Milgrom, SA; Ohanian, M; Pemmaraju, N; Pinnix, CC; Smith, GL; Woodman, K | 1 |
HEINLE, RW; WELCH, AD | 1 |
Biswal, BK; Verma, RS | 1 |
Eden, T | 1 |
Carson, WE; Kondadasula, SV; Lee, RJ; Li, H; Lu, Y; Piao, L; Wu, J; Yang, X | 1 |
Cabelof, DC; Patterson, D | 1 |
Bugaj, M; Dzik, JM; Gołos, B; Kusakiewicz-Dawid, A; Pawełczak, K; Rode, W; Rzeszotarska, B; Wińska, P | 1 |
Gifford, AJ; Haber, M; Matherly, LH; Norris, MD; Taub, JW; Whetstine, JR; Witt, TL | 1 |
Assaraf, YG; Bunni, MA; Jansen, G; Liani, E; Rothem, L; Smith, CA | 1 |
Aronheim, A; Assaraf, YG; Rothem, L | 1 |
PAOLINO, W | 1 |
MALLARME, J | 1 |
RITCHIE, GM | 1 |
BROQUIST, HP | 1 |
BAUMANN, CA | 1 |
KIELER, J | 1 |
SPRAY, GH; WITTS, LJ | 1 |
GALARDESCHI, O; SPIGLIATI, P | 3 |
GOLDIN, A; GREENHOUSE, SW; HUMPHREYS, SR; MANTEL, N; VENDITTI, JM | 1 |
JIMENEZ DE ASUA, F | 1 |
BRAHIN, C; KRIM, M; MEYER, LM; RITZ, N | 1 |
BURCHENAL, JH; ELLISON, RR; KARNOFSKY, DA; MURPHY, ML | 1 |
BURCHENAL, JH | 2 |
CONSOLI, G | 1 |
DENNIS, D; GOLDIN, A; HUMPHREYS, SR; MANTEL, N; VENDITTI, JM | 1 |
RAUSCH, F | 1 |
HAEHNER, E; LOZANO, R; LUDES, H | 1 |
FISCHER, GA; WELCH, AD | 1 |
GOLDIN, A; HUMPHREYS, ST; MANTEL, N; VENDITTI, JM | 1 |
JOSKE, RA; MACKINNON, NL; PITNEY, WR | 1 |
BEARD, D; BEARD, JW; BEAUDREAU, GS; BECKER, C; CASTLE, W; GIBSON, BW | 1 |
LYNCH, TJ; MOLONEY, WC | 1 |
BRODY, JI; MCKENZIE, D | 1 |
SLAVIK, K; SOCHMAN, J; SOUCEK, J | 1 |
WILMANNS, W | 4 |
FELDMAN, BH; SCHULANER, FA | 1 |
BERLIN, NI; FREIREICH, EJ; HERTZ, R; LIPSETT, MB; MEAD, JA; RALL, D; VANSCOTT, E | 1 |
JAENICKE, L; WILMANNS, W | 2 |
SHARP, AA | 1 |
MISRA, DK | 1 |
GIRDWOOD, RH; KERSHAW, PW | 1 |
CHALMERS, TM; MCCARTHY, DD | 1 |
MOTYCKA, K; SLAVIK, K; SOUCEK, J | 1 |
DUPREE, LT; SANFORD, KK | 1 |
JIRASEK, A; JIRASEK, J; MOTYCKA, K; SLAVIK, K; SOUCEK, J | 1 |
HOGAN, JA; MANIATIS, A; MOLONEY, WC | 1 |
MACGIBBON, BH; MOLLIN, DL | 1 |
COX, RP; FRIEND, C; HADDAD, JR; SILBER, R | 1 |
ROSE, DP | 1 |
EINHORN, J; LAGERLOEF, B; RAO, PB; REIZENSTEIN, PG | 1 |
CRAWFORD, EJ; FRIEDKIN, M; GOLDIN, A; HUMPHREYS, SR; KASHKET, ER | 1 |
ACEVEDO, G; MAUER, AM | 1 |
O'BRIEN, JS; WALSH, JR | 1 |
MOORE, AE; POGO, BG | 1 |
BRIGGS, GM; POTTER, M | 1 |
BELL, M; CHAPMAN, JB; SKIPPER, HE | 1 |
BOCK, G; MEYER, LM; MILLER, FR; ROWEN, MJ; RUTZKY, J | 1 |
HANLON, DG; MASON, HL; STICKNEY, JM | 1 |
BIEDLER, JL; BURCHENAL, JH; MEIGS, GM; WEBBER, LF | 1 |
LAW, LW | 1 |
JOHNSON, EP | 1 |
BASERGA, A | 1 |
MEYER, LM; RUTZKY, J | 1 |
BETHELL, FH; BIRD, OD; SWENDSEID, ME | 1 |
EARLE, AM; LAWSON, WG; REILLY, WA | 1 |
BARTA, I | 1 |
BETHELL, FH; MILLER, S; SWANSON, AL; SWENDSEID, ME | 1 |
BETHELL, FH; MEYERS, MC; SWANSON, AL; SWENDSEID, ME | 1 |
BOCK, G; BRAHIN, CM; JACOBSON, J; KRIM, M; MEYER, LM; RITZ, ND; SAWITSKY, A; SCHWARTZ, SO | 1 |
Lightfoot, TJ; Roman, E | 1 |
CARROLL, GJ; HUNTER, OB | 1 |
BURCHENAL, JH; ROBINSON, E | 1 |
HEINLE, RW; KARPINSKI, FE; WEBER, EJ | 1 |
BRADFORD, GT; SACKS, MS; SCHOENBACH, EB | 1 |
HAGEDORN, AB; MILLS, SD; STICKNEY, JM | 1 |
FARBER, S | 2 |
NOLAN, CW; RISER, WH; SKIPPER, HE | 1 |
SOTO, AR | 1 |
WILSON, SJ | 1 |
SILVERMAN, FN | 2 |
SHAFIK ABBASY, A | 1 |
McCALL, FC; SCHERER, JH | 1 |
BELL, WR; SMITH, CH | 1 |
DACIE, JV; DRESNER, E; MOLLIN, DL; WHITE, JC | 1 |
DUBOIS-FERRIERE, H | 1 |
McNEIL, DL | 1 |
CASSIDY, JE; CROWELL, WM; JUDGE, DF; LEYVA, FR; RICE, EC; TROENDLE, FJ; VADEN, EB | 1 |
MARMONT, A | 1 |
BOYLE, PJ; LAW, LW | 1 |
Gao, XN; Tang, SQ | 1 |
Cowan, KH; Dixon, KH; Eng, SC; Trepel, JB | 1 |
Barragan, E; Bolufer, P; Cervera, J; Collado, M; López, JA; Sanz, MA | 1 |
Barale, R; Buda, G; Galimberti, S; Maggini, V; Petrini, M; Rossi, AM | 1 |
HOLT, C; JACOBSON, W; LEVIN, WC | 1 |
ALT, H; PIERCE, M | 1 |
AXELROD, AR; BERMAN, L | 2 |
DAMESHEK, W | 1 |
BURCHENAL, JH; BURCHENAL, JR | 1 |
FINK, H; MEYER, LM | 1 |
BURCHENAL, JH; JOHNSTON, SF | 1 |
BURCHENAL, JH; KUSHIDA, MN | 1 |
MILLS, SD; STICKNEY, JM | 1 |
DUNN, TB; LAW, LW | 1 |
BOSSI, C; COXSEY, L; WILSON, SJ | 1 |
Hall, TC; Roberts, D | 1 |
Ahmed, T; DeGraw, JI; Moccio, DM; Piper, JR; Samuels, LL; Sirotnak, FM; Yagoda, A | 1 |
Spivak, JL; Vogelsang, GB | 1 |
Boyle, FT; Forsch, RA; Hynes, JB; Jackman, AL; Kathmann, I; Peters, GJ; Pinedo, HM; Rosowsky, A; Schornagel, JH; Westerhof, GR | 1 |
Ando, Y; Miyachi, H; Takemura, Y | 1 |
Ando, K; Ando, Y; Kobayashi, H; Miyachi, H; Takemura, Y | 1 |
Ando, Y; Kobayashi, H; Miyachi, H; Takemura, Y | 1 |
Assaraf, YG; Bunni, M; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Schornagel, JH; Sprecher, H | 1 |
Assaraf, YG; Drori, S; Goldman, ID; Jansen, G; Shemer, G; Sprecher, H | 1 |
Assaraf, YG; Drori, S; Jansen, G; Mauritz, R; Peters, GJ | 1 |
Spiers, AS | 1 |
Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH | 1 |
Danenberg, PV; Lockshin, A | 1 |
Blair, JA; Cooke, WT; Leeming, RJ; Melikian, V; Thien, KR | 1 |
Henderson, GB; Russell, A; Singh, P; Whiteley, JM; Zevely, EM | 1 |
Ambrosetti, A; Bambara, LM; Corrocher, R; De Sandre, G; Hoffbrand, AV; Pachor, ML | 1 |
Girdwood, RH | 1 |
Bambara, LM; Corrocher, R; De Sandre, G; Pachor, ML; Perona, G; Pizzolo, G | 1 |
Blair, JA; Leeming, RJ; Melikian, V; O'Gorman, DJ | 1 |
Bernard, J; Brière, J; Brière, JF; Castro-Malaspina, H | 1 |
Hoffbrand, AV; Lavoie, A; Parsa, K; Tripp, E | 1 |
Magnus, EM | 2 |
Aspnes, GT; Kalavsky, SM; Kammerer, BL; Klatskin, EH; McIntosh, S; O'Brien, RT; Pearson, HA; Snead, C | 1 |
Carter, SK; Kershner, LM | 1 |
Freisheim, JH; Jansen, G; McAlinden, TP; Prasad, KM; Ratnam, M; Schornagel, JH; Westerhof, GR; Williams, FE | 1 |
Ando, Y; Miyachi, H; Scanlon, KJ; Takemura, Y | 1 |
Fuhry, MA; Janson, CA; Jordan, SR; Matthews, DA; Nguyen, D; Pino, MJ; Reich, SH; Smith, WW; Webber, S; Welsh, KM | 1 |
Jackman, AL; Jansen, G; Newell, DR; Rijksen, G; Schornagel, JH; Westerhof, GR | 1 |
Duch, DS; Edelstein, MP; Ferone, R; Gaumont, Y; Kisliuk, RL; Murthy, BR; Nair, MG; Patil, SD; Thorndike, J | 1 |
Jansen, G; Rijksen, G; Schornagel, JH; van der Veer, LJ; Westerhof, GR | 1 |
Jansen, G; Rijksen, G; Schornagel, JH; Westerhof, GR | 1 |
Keyomarsi, K; Moran, RG | 1 |
Chen, AT; Green, RJ; Phillips, DL; Ragab, AH; Reidy, JA | 1 |
Abels, J; Ermens, AA; Kroes, AC; Lindemans, J; Schoester, M; van Lom, K | 1 |
Vives Corrons, JL; Vives Mañé, J | 1 |
Arakawa, T; Chiba, R; Chida, N; Hayashi, T; Kakizaki, R; Konno, T; Wada, Y | 1 |
Israëls, MC; Noeypatimanond, S; Watson-Williams, EJ | 1 |
Jaenicke, L; Sauer, H; Wilmanns, W; Wilms, K | 1 |
Valencia, R | 1 |
Blair, JA; Cooke, WT; Leeming, RJ; Melikian, V; Ratanasthien, K | 1 |
Konrad, PN; Paglia, DE; Valentine, WN | 1 |
Gupta, OP | 1 |
Beavon, JR; Blair, JA; Dransfield, E; Leeming, RJ; Ratanasthien, K; Staff, FJ | 1 |
Harris, RF; Innes, EM; Kay, HE; Knapton, PJ; O'Sullivan, JP; Schwartz, FC; Stuart, J; Thompson, EN; Wells, DG | 1 |
Bloom, AL; Jacobs, A | 1 |
Bart, JB | 1 |
Friedkin, M | 1 |
Banerjee, DK; Basu, AK; Maitra, A | 1 |
Rothenberg, SP | 1 |
Bertino, JR; Hillcoat, BL | 1 |
Reizenstein, P | 1 |
Katayama, N; Kawakita, Y; Yamazaki, T | 1 |
Baker, H; Gilbert, HS; Hoogstraten, B | 1 |
Jondorf, WR | 1 |
Bertino, JR; Hryniuk, WM | 1 |
Nicholson, HO | 1 |
Catovsky, D; Dacie, JV; Hoffbrand, AV; Shaw, MT | 1 |
Gabriel, FD; Rosner, F | 1 |
Hoagland, HC; Linman, JW; Pierre, RV | 1 |
Benso, L; Bonenti, G; Nigro, N | 1 |
Yoshino, T | 2 |
Karlin, R | 1 |
Schmidt, CG | 1 |
Begemann, H | 1 |
Grignani, F; Larizza, P | 1 |
13 review(s) available for folic acid and Leukemia
Article | Year |
---|---|
Potential Benefits and Pitfalls of Histidine Supplementation for Cancer Therapy Enhancement.
Topics: Animals; Dietary Supplements; Folic Acid; Formiminoglutamic Acid; Histidine; Humans; Leukemia; Methotrexate; Neoplasms | 2020 |
Aetiology of childhood leukaemia.
Topics: Alcohol Drinking; Background Radiation; Child; Electromagnetic Fields; Folic Acid; Genetic Predisposition to Disease; Humans; Incidence; Leukemia; Seasons; Smoking | 2010 |
Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging.
Topics: Aging; Animals; DNA Polymerase beta; DNA Repair; Down Syndrome; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Genomic Instability; Haploinsufficiency; Humans; Leukemia; MicroRNAs; Oxidative Stress; Phenotype | 2012 |
[FOLIC ACID METABOLISM AND ONE-CARBON UNITS].
Topics: Avitaminosis; Biochemical Phenomena; Carbon; Coenzymes; Escherichia coli; Folic Acid; Folic Acid Antagonists; Hematology; Humans; Leukemia; Metabolism; Neoplasms | 1963 |
Causes of childhood leukaemia and lymphoma.
Topics: Animals; Carcinogens; Child; Diet; Environmental Exposure; Fertility; Folic Acid; Humans; Infant; Infant Food; Leukemia; Leukemia, Radiation-Induced; Life Style; Lymphoma | 2004 |
[Folate receptor and its application in the selective receptor-mediated targeting therapy of tumor cells--review].
Topics: Antineoplastic Agents; Carrier Proteins; Drug Delivery Systems; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Leukemia; Receptors, Cell Surface; Tretinoin; Tumor Cells, Cultured | 2005 |
Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression.
Topics: Animals; Disease Progression; DNA Repair; Enzymes; Folic Acid; Genetic Variation; Humans; Leukemia; Polymorphism, Genetic; Risk Factors | 2006 |
Drug-induced anaemias.
Topics: Anemia; Anemia, Aplastic; Anemia, Megaloblastic; Anemia, Sideroblastic; Anticonvulsants; Bone Marrow; Chloramphenicol; Chromosomes; Contraceptives, Oral; Drug Hypersensitivity; Erythrocytes; Folic Acid; Folic Acid Antagonists; Hemorrhage; Humans; Leukemia; Trimethoprim | 1976 |
[Control of cellular division by vitamin B 12 and folates].
Topics: Anemia, Macrocytic; Anemia, Pernicious; Animals; Cell Division; Euglena gracilis; Folic Acid; Folic Acid Deficiency; Humans; Leukemia; Methylation; Nucleic Acids; Nucleotides; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
Advances in the treatment of blood disorders.
Topics: Anemia, Aplastic; Anemia, Hypochromic; Anemia, Macrocytic; Antibodies, Anti-Idiotypic; Antineoplastic Agents; Blood Transfusion; Child; Disseminated Intravascular Coagulation; Erythroblastosis, Fetal; Female; Folic Acid; Hematologic Diseases; Humans; Hydroxocobalamin; Infant; Infant, Newborn; Iron; Leukemia; Multiple Myeloma; Polycythemia Vera; Pregnancy; Purpura, Thrombocytopenic; Thrombosis | 1972 |
Regulation of dihydrofolate reductase and other folate-requiring enzymes.
Topics: Alcohol Oxidoreductases; Animals; Enzyme Induction; Erythrocytes; Escherichia coli; Folic Acid; Folic Acid Antagonists; Formates; Guinea Pigs; Homocysteine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukemia; Leukocytes; Ligases; Methotrexate; Oxidoreductases; Rats; Salmonella typhimurium; Serine; Streptococcus; Tetrahydrofolate Dehydrogenase | 1968 |
[Leukemia and nutrition--pathologic metabolism and distribution of protein, fat, folic acid, and iron].
Topics: Aged; Amino Acids; Asparagine; Fats; Folic Acid; Humans; Iron; Leukemia; Lymphoma; Middle Aged | 1970 |
[Recent progress in hematology].
Topics: Anemia, Macrocytic; Complement System Proteins; Erythropoietin; Folic Acid; Humans; Leukemia; Vitamin B 12 | 1971 |
181 other study(ies) available for folic acid and Leukemia
Article | Year |
---|---|
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.
Topics: Amide Synthases; Aminopterin; Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia L1210; Ligases; Male; Methotrexate; Tetrahydrofolates; Thymidylate Synthase | 1985 |
Pharmacological inhibition of the mixed lineage leukemia 1-menin interaction aggravates acute kidney injury induced by folic acid and ischemia-reperfusion in mice.
Topics: Acute Kidney Injury; Animals; Creatinine; ErbB Receptors; Folic Acid; Histones; Ischemia; Leukemia; Lysine; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein; Reperfusion; Reperfusion Injury; Transcription Factors | 2023 |
Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection.
Topics: Animals; Cell Line, Tumor; Cell Membrane; Coloring Agents; Fluorescence; Folic Acid; Humans; Leukemia; Mice; Mice, Nude; Nanoparticles; Sulfides; Zinc | 2017 |
Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia.
Topics: Animals; Cell Line, Tumor; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Kinesins; Leukemia; Mice, Nude; Polyethylene Glycols; RNA Interference; RNA Stability; RNA, Small Interfering; RNAi Therapeutics | 2017 |
Leukemia-specific delivery of mutant NOTCH1 targeted therapy.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Endocytosis; Folate Receptor 2; Folic Acid; Gene Expression; Humans; Leukemia; Mice; Mutation; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Receptor, Notch1; Signal Transduction; Thapsigargin; Xenograft Model Antitumor Assays | 2018 |
Folate Receptor-Targeted and GSH-Responsive Carboxymethyl Chitosan Nanoparticles Containing Covalently Entrapped 6-Mercaptopurine for Enhanced Intracellular Drug Delivery in Leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Chemoradiotherapy; Drug Carriers; Drug Liberation; Drug Screening Assays, Antitumor; Drug Stability; Fibroblasts; Folate Receptors, GPI-Anchored; Folic Acid; Glutathione; HL-60 Cells; Humans; Leukemia; Mercaptopurine; Mice; Microscopy, Electron, Transmission; Nanoparticles | 2018 |
Drug embedded PVP coated magnetic nanoparticles for targeted killing of breast cancer cells.
Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Chemistry, Pharmaceutical; Coated Materials, Biocompatible; Drug Delivery Systems; Epirubicin; Female; Folic Acid; Humans; Leukemia; Lung Neoplasms; Magnetite Nanoparticles; Male; Pharmaceutic Aids; Povidone; Prostatic Neoplasms; Spectroscopy, Fourier Transform Infrared | 2013 |
Multistep targeted nano drug delivery system aiming at leukemic stem cells and minimal residual disease.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Line, Tumor; Drug Delivery Systems; Durapatite; Folic Acid; Humans; Leukemia; Leukocytes; Mice; Mitoxantrone; Neoplasm, Residual; Neoplastic Stem Cells; Polyethylene Glycols; Rats | 2013 |
Diet and risk of adult leukemia: a multicenter case-control study in China.
Topics: Adult; Aged; Animals; Ascorbic Acid; Carotenoids; Case-Control Studies; China; Diet; Dietary Fiber; Feeding Behavior; Female; Folic Acid; Food; Humans; Leukemia; Logistic Models; Male; Middle Aged; Niacin; Odds Ratio; Riboflavin; Risk Factors; Surveys and Questionnaires; Thiamine; Vitamins | 2015 |
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase, dietary folate intake, and the risk of leukemia in adults.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Diet; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leukemia; Leukemia, Myeloid; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Sex Factors; Surveys and Questionnaires; Thymidylate Synthase; Young Adult | 2016 |
Dorsal column myelopathy after intrathecal chemotherapy for leukemia.
Topics: Antimetabolites, Antineoplastic; Diagnosis, Differential; Electronic Health Records; Female; Folic Acid; Homocysteine; Humans; Injections, Spinal; Leukemia; Magnetic Resonance Imaging; Male; Methotrexate; Spinal Cord Diseases; Subacute Combined Degeneration | 2017 |
Experiments with pteroylglutamic acid and pteroylglutamic acid deficiency in human leukemia.
Topics: Folic Acid; Leukemia | 1948 |
Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells.
Topics: Antibodies; Biological Transport; Buffers; Carrier Proteins; Cell Line, Tumor; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Ions; Leukemia; Membrane Transport Proteins; Methotrexate; Mitomycin; Phosphates; Receptors, Cell Surface; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; Sulfasalazine; Sulfates; T-Lymphocytes; Time Factors; Verapamil | 2009 |
Folate-immunoglobulin G as an anticancer therapeutic antibody.
Topics: Animals; Carrier Proteins; Cell Line, Tumor; Cell Survival; Cytokines; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Immunoglobulin G; Leukemia; Liposomes; Mice; Mice, Inbred DBA; Receptors, Cell Surface | 2010 |
Synthesis and biological activity of N(alpha)-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid.
Topics: Animals; Folic Acid; Glutamic Acid; Leukemia; Mice; Rats | 2002 |
Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells.
Topics: Amino Acid Substitution; Antimetabolites, Antineoplastic; Bone Marrow Cells; Carrier Proteins; Child; Drug Resistance, Neoplasm; Folic Acid; Humans; Kinetics; Leukemia; Membrane Transport Proteins; Methotrexate; Point Mutation; Protein Structure, Tertiary; Reduced Folate Carrier Protein; Transfection; Tumor Cells, Cultured | 2002 |
Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines.
Topics: Base Sequence; Binding Sites; Biological Transport; Blotting, Northern; Blotting, Western; Cell Division; DNA Primers; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Genes, Dominant; Humans; Leukemia; Mutation; Peptide Synthases; Polyglutamic Acid; Polymorphism, Single-Stranded Conformational; Protein Conformation; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured | 2003 |
Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells.
Topics: Alleles; Biological Transport; Blotting, Western; Carrier Proteins; Cell Division; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Folic Acid; Folic Acid Antagonists; Gene Silencing; Genes, Reporter; Genetic Vectors; Humans; Leukemia; Leukemia, T-Cell; Luciferases; Membrane Transport Proteins; Oligonucleotides; Promoter Regions, Genetic; Protein Binding; Protein Isoforms; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sp1 Transcription Factor; Sp3 Transcription Factor; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 2003 |
[Folic acid antagonists in therapy of leukemia and tumors; problem of resistance and relations with the citrovorum factor].
Topics: Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Leukemia; Neoplasms | 1952 |
[Aminopterin in the treatment of malignant leukemia and its antidote--folic acid].
Topics: Aminopterin; Antidotes; Folic Acid; Folic Acid Antagonists; Leukemia | 1952 |
Extensive myeloid response during folic acid therapy in megaloblastic anaemia of pregnancy.
Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Folic Acid; Humans; Leukemia; Pregnancy | 1952 |
Role of folic acid and citrovorum factor in metabolic processes and their relation to cancer.
Topics: Antimetabolites; Biochemical Phenomena; Folic Acid; Leucovorin; Leukemia; Neoplasms | 1952 |
Citrovorum factor; nutritional aspects, associations with leukemia and anemia.
Topics: Anemia; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Leukemia | 1953 |
Combination therapy of chloroleukemia in mice with aminopterin and citrovorum factor.
Topics: Aminopterin; Animals; Combined Modality Therapy; Folic Acid; Leucovorin; Leukemia; Mice; Sarcoma, Myeloid | 1953 |
The utilisation of folic acid in anaemia and leukaemia.
Topics: Anemia; Folic Acid; Humans; Leukemia | 1953 |
[Therapeutic experimentation with citrovorum factor in acute leukemia; folic acid deficiency as the etiopathogenic factor essential in transformation of chronic stage of leukemia into acute].
Topics: Acute Disease; Antimetabolites; Folic Acid; Folic Acid Deficiency; Leucovorin; Leukemia; Leukemia, Myeloid | 1953 |
[Studies on interference of aminopterin and folic acid with process of maturation of leukemic cell].
Topics: Aminopterin; Folic Acid; Humans; Leukemia | 1953 |
Estimation of the antileukemic potency of the antimetabolite aminopterin, administered alone and in combination with citrovorum factor or folic acid.
Topics: Aminopterin; Antimetabolites; Folic Acid; Leucovorin; Leukemia; Leukemia, Lymphoid; Lymphatic Vessels | 1953 |
[Considerations on the treatment of acute leukemias with special reference to the action of citrovorum factor, leukovorine].
Topics: Acute Disease; Antimetabolites; Folic Acid; Leucovorin; Leukemia | 1953 |
Remission in chronic myelocytic leukemia during folic acid therapy.
Topics: Folic Acid; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid | 1954 |
Clinical effects of the dichloro and monochlorophenyl analogues of diamino pyrimidine: antagonists of folic acid.
Topics: Folic Acid; Humans; Leukemia; Pyrimidines | 1954 |
Clinical effects of analogs of folic acid, purines, pyrimidines, and amino acids.
Topics: Amino Acids; Folic Acid; Folic Acid Antagonists; Humans; Inorganic Chemicals; Leukemia; Purines; Pyrimidines | 1954 |
[Associated citrovorum factor-aminopterin treatment in acute leukemia].
Topics: Acute Disease; Aminopterin; Antimetabolites; Folic Acid; Leucovorin; Leukemia | 1955 |
Studies on the management of mouse leukemia (L1210) with antagonists of folic acid.
Topics: Animals; Disease Management; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Experimental | 1955 |
[Anaphylactic shock after folic acid therapy].
Topics: Anaphylaxis; Folic Acid; Humans; Hypersensitivity; Immune System Diseases; Leukemia; Leukemia, Lymphoid | 1956 |
[Peroral folic acid loading test in leukemia and Hodgkin's disease].
Topics: Blood Gas Analysis; Folic Acid; Hodgkin Disease; Humans; Leukemia | 1956 |
[Recurrence of acute phase in leukemia; functional recuperation of normal granulopoiesis with therapeutic use of citrovorum factor].
Topics: Folic Acid; Leucovorin; Leukemia; Neoplasms; Recurrence | 1955 |
Effect of citrovorum factor and peptones on mouse leukemia cells L-5178 in tissue culture.
Topics: Animals; Folic Acid; Leucovorin; Leukemia; Neoplasms, Experimental; Peptones; Research Design; Tissue Culture Techniques | 1957 |
Comparison of the relative effectiveness of folic acid congeners against advanced leukemia in mice.
Topics: Animals; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Mice | 1957 |
Folic acid and other absorption tests in lymphosarcoma, chronic lymphocytic leukaemia, and some related conditions.
Topics: Animals; Folic Acid; Hodgkin Disease; Humans; Intestines; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphocytes; Lymphoma; Lymphoma, Non-Hodgkin | 1960 |
Virus of avian myeloblastosis. XXII. Influence of folic acid and other factors on growth of myeloblasts and virus synthesis in tissue culture.
Topics: Folic Acid; Granulocyte Precursor Cells; Humans; Leukemia; Research Design; Viruses | 1962 |
Observations on serum B-12 and folate activity in normal and leukemic rats.
Topics: Animals; Folic Acid; Hematinics; Leukemia; Leukemia, Experimental; Rats; Vitamin B 12; Vitamin B Complex | 1963 |
Synergistic toxicity of triethylene thiophosphoramide and folic acid in the IRC-741 leukemia.
Topics: Folic Acid; Leukemia; Leukemia, Experimental; Thiotepa | 1963 |
Activity changes of some enzyme systems interferring into the metabolism of folic acid in the livers of mice in the course of LaHVUFB leucaemia.
Topics: Animals; Folic Acid; Folic Acid Antagonists; Fructose-Bisphosphate Aldolase; Leukemia; Leukemia, Experimental; Liver; Mice; Oxidoreductases; Transferrin | 1963 |
[On the mechanism of action of folic acid and purine antagonists in the treatment of acute leukemias].
Topics: Antimetabolites; Folic Acid; Leukemia; Purines | 1963 |
[Determination, properties and significance of dihydrofolic acid reductase in the white blood cells in leukemia].
Topics: Folic Acid; Humans; Leukemia; Leukocyte Count; Leukocytes; Oxidoreductases | 1962 |
INTUSSUSCEPTION AS A CAUSE OF DEATH IN ACUTE LEUKEMIA; REPORT OF A CASE.
Topics: Cause of Death; Child; Death, Sudden; Folic Acid; Humans; Intussusception; Leukemia; Leukemia, Lymphoid; Lymphocytes; Lymphoma, Non-Hodgkin; Mercaptopurine; Steroids | 1963 |
FOLIC ACID ANTAGONIST. EFFECTS ON THE CELL AND THE PATIENT. COMBINED CLINICAL STAFF CONFERENCE AT THE NATIONAL INSTITUTES OF HEALTH.
Topics: Biochemical Phenomena; Biochemistry; Bone Marrow; Child; Choriocarcinoma; Epithelium; Female; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Metabolism; National Institutes of Health (U.S.); Pathology; Pharmacology; Pregnancy; Toxicology; Trophoblastic Neoplasms; United States | 1963 |
[THE SIGNIFICANCE OF THE FOLIC ACID METABOLISM FOR THE NORMAL AND PATHOLOGICAL MATURATION OF BLOOD CELLS].
Topics: Blood Cells; Folic Acid; Humans; Isomerases; Leucovorin; Leukemia; Mercaptopurine; Metabolism; Methotrexate; Oxidoreductases | 1963 |
MACROCYTIC ANAEMIA, LEUKAEMIA AND HAEMOGLOBINOPATHIES.
Topics: Anemia, Macrocytic; Avitaminosis; Eye Manifestations; Folic Acid; Hemoglobinopathies; Hemoglobins; Hemoglobins, Abnormal; Leukemia; Thalassemia; Vitamin B 12 Deficiency | 1963 |
A DIRECT ASSAY FOR DIHYDROFOLATE REDUCTASE IN HUMAN LEUKOCYTES.
Topics: Animals; Chemistry Techniques, Analytical; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Leukemia, Myeloid; Leukocytes; Methotrexate; Mice; Microchemistry; NADP; Neoplasms; Oxidoreductases; Research; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1964 |
SOME INVESTIGATIONS OF FOLIC-ACID DEFICIENCY.
Topics: Anemia; Anemia, Hemolytic; Anemia, Macrocytic; Anticonvulsants; Biomedical Research; Blood Chemical Analysis; Female; Folic Acid; Folic Acid Deficiency; Geriatrics; Glutamates; Histidine; Leukemia; Liver Diseases; Metabolism; Neoplasms; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Urine; Vitamin B 12 Deficiency | 1964 |
HEMATOLOGICAL COMPLICATIONS OF PHENYLBUTAZONE THERAPY: REVIEW OF THE LITERATURE AND REPORT OF TWO CASES.
Topics: Adrenocorticotropic Hormone; Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Arthritis; Arthritis, Rheumatoid; Blood Platelet Disorders; Blood Transfusion; Folic Acid; Hematology; Humans; Leukemia; Leukocyte Count; Leukopenia; Phenylbutazone; Prednisolone; Thrombocytopenia; Toxicology | 1964 |
ACTIVITY CHANGES OF SOME ENZYME SYSTEMS INTERFERING IN FOLIC ACID METABOLISM IN THE COURSE OF MOUSE LEUKAEMIA OF AKR-STRAIN.
Topics: Aldehyde-Lyases; Animals; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Liver; Metabolism; Mice; Mice, Inbred AKR; Oxidoreductases; Research; Transferases | 1964 |
ACTIVITY OF VITAMIN B12 IN MAMMALIAN CELLS IN TISSUE CULTURE.
Topics: Animals; Chick Embryo; Cricetinae; Culture Media; Folic Acid; Haplorhini; Kidney; Leukemia; Leukemia, Lymphoid; Lymphocytes; Mice; Parotid Gland; Pharmacology; Research; Research Design; Skin; Tissue Culture Techniques; Vitamin B 12 | 1964 |
THE TREATMENT OF EXPERIMENTAL MOUSE HEMOBLASTOSIS. I. THE EFFECT OF SOME NEW FOLIC ACID ANTIMETABOLITES ON CELL TRANSPLANTED LEUKEMIA IN MICE OF THE AKR STRAIN.
Topics: Aminopterin; Animals; Antimetabolites; Antineoplastic Agents; Folic Acid; Leukemia; Leukemia, Experimental; Leukocyte Count; Methotrexate; Mice; Mice, Inbred AKR; Pharmacology; Research; Toxicology | 1964 |
THE SERUM LACTOBACILLUS CASEI FOLATE CLEARANCE TEST IN VARIOUS HEMATOLOGIC DISORDERS.
Topics: Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Macrocytic; Blood Chemical Analysis; Folic Acid; Folic Acid Deficiency; Hematologic Diseases; Humans; Lacticaseibacillus casei; Lactobacillus; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Metabolism; Myeloproliferative Disorders; Polycythemia Vera; Primary Myelofibrosis | 1964 |
SIDEROBLASTIC ANAEMIA IN MAN: OBSERVATIONS ON SEVENTY CASES.
Topics: Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Sideroblastic; Arthritis; Arthritis, Rheumatoid; Bone Marrow Examination; Diagnosis, Differential; Drug Therapy; Elliptocytosis, Hereditary; Folic Acid; Folic Acid Deficiency; Humans; Leukemia; Malabsorption Syndromes; Pathology; Polycythemia Vera; Spherocytosis, Hereditary; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency | 1965 |
ENZYME STUDIES IN VIRUS-INDUCED NEOPLASMS. I. THE EFFECT OF A MURINE LEUKEMIA ON ENZYMES OF ONE-CARBON METABOLISM AND ON PHOSPHOMONOESTERASES.
Topics: Alkaline Phosphatase; Animals; Carbon; Esterases; Folic Acid; Histocytochemistry; Leukemia; Leukemia Virus, Murine; Leukemia, Experimental; Ligases; Liver; Metabolism; Mice; Oxidoreductases; Phosphoric Monoester Hydrolases; Research; Spleen; Splenectomy; Thymidine | 1964 |
VALUE OF DETECTION OF FORMIMINOGLUTAMIC ACID IN URINE FOR THE DIAGNOSIS OF MALABSORPTION STATES.
Topics: Bile Duct Neoplasms; Carbohydrate Metabolism; Celiac Disease; Crohn Disease; Diagnosis; Electrophoresis; Enteritis; Fatty Acids; FIGLU Test; Fluids and Secretions; Folic Acid; Formiminoglutamic Acid; Histidine; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Lymphoma, Non-Hodgkin; Malabsorption Syndromes; Sprue, Tropical; Urine; Vitamin B 12; Xylose | 1965 |
FOLIC ACID ACTIVITY IN LEUKEMIA AND CANCER.
Topics: Animals; Avian Leukosis Virus; Biological Assay; Blood; Blood Cell Count; Blood Sedimentation; Folic Acid; Geriatrics; Hemoglobins; Hodgkin Disease; Humans; Lactobacillus; Leukemia; Neoplasm Metastasis; Neoplasms; Plasma; Poultry | 1965 |
ON THE SIMILARITY OF DIHYDROFOLATE REDUCTASES FROM AMETHOPTERIN-SENSITIVE AND AMETHOPTERIN-RESISTANT MOUSE LEUKEMIA (L1210) CELLS.
Topics: Animals; Benzoates; Enzyme Inhibitors; Folic Acid; Leukemia; Leukemia, Experimental; Methotrexate; Mice; NADP; Oxidoreductases; Pharmacology; Research; Sodium Chloride; Tetrahydrofolate Dehydrogenase | 1964 |
THE EFFECT OF LARGE INTRAVENOUS DOSES OF METHOTREXATE ON URINARY FORMIMINOGLUTAMIC ACID EXCRETION.
Topics: Child; Drug Therapy; FIGLU Test; Folic Acid; Formiminoglutamic Acid; Glutamates; Humans; Injections, Intravenous; Leukemia; Metabolism; Methotrexate; Urine | 1965 |
Folinic acid activity in leucocytes.
Topics: Folic Acid; Hematologic Tests; Humans; Leucovorin; Leukemia; Leukocytes | 1962 |
Effect of folic acid on in vitro uptake of labeled thymidine by leukemic cells.
Topics: Biochemical Phenomena; Folic Acid; In Vitro Techniques; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Nucleosides; Nucleotides; Thymidine | 1961 |
Inhibition of growth of amethopterinsensitive and amethopterin-resistant pairs of lymphocytic neoplasms by dietary folic-acid deficiency in mice.
Topics: Animals; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Leukemia; Leukemia, Lymphoid; Lymphocytes; Lymphoma; Methotrexate; Mice; Neoplasms, Experimental | 1962 |
Studies on the role of folic acid in the leukemic process.
Topics: Folic Acid; Folic Acid Antagonists; Humans; Leukemia | 1950 |
Treatment of acute leukemia with amethopterin (4-amino, 10-methyl pteroyl glutamic acid).
Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Glutamates; Leukemia; Methotrexate | 1950 |
The urinary excretion of 17-ketosteroids and corticosteroids in leukemia; the effects of aminopterin (4-amino-pteroylglutamic acid) on the excretion of corticosteroids in acute leukemia.
Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aminopterin; Androgens; Dermatologic Agents; Folic Acid; Folic Acid Antagonists; Glucocorticoids; Leukemia | 1950 |
A comparison of the effects of 4-amino-N10-methyl-pteroylglutamic acid and 2,6-diaminopurine upon sensitive and resistant sublines of a strain of mouse leukemia.
Topics: 2-Aminopurine; Amino Acids; Animals; Folic Acid; Leukemia; Mice | 1951 |
FOLACIN antagonists in the treatment of acute leukemia.
Topics: Folic Acid; Folic Acid Antagonists; Humans; Leukemia | 1951 |
Response of a resistant variant of leukemic cells to an antagonist of pteroylglutamic acid.
Topics: Folic Acid; Folic Acid Antagonists; Leukemia; Musculoskeletal Physiological Phenomena | 1951 |
The effect of 4-aminopteroylglutamic acid (aminopterin), a folic acid antagonist on experimentally produced avian leukosis.
Topics: Aminopterin; Animals; Avian Leukosis; Bird Diseases; Birds; Folic Acid; Folic Acid Antagonists; Leukemia; Meat; Poultry | 1951 |
[Investigation of folic acid antagonist therapy in cancer of hemopoietic organs and leukemia].
Topics: Folic Acid; Folic Acid Antagonists; Hematopoietic System; Leukemia; Neoplasms | 1951 |
An unusual case of acute plasma-cell leukemia treated with a folic acid antagonist and urethane.
Topics: Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Plasma Cell; Urethane | 1951 |
The concentration of folic acid in leukocytes; observations on normal subjects and persons with leukemia.
Topics: Folic Acid; Leukemia; Leukocytes | 1951 |
Citrovorum factor in leucemia; two cases with autopsy findings.
Topics: Autopsy; Folic Acid; Leucovorin; Leukemia | 1951 |
[New data on the therapy and pathogenesis of pernicious anemia and leukemia].
Topics: Anemia; Anemia, Pernicious; Folic Acid; Hematinics; Leukemia; Vitamin B 12 | 1951 |
The metabolic displacement of folic acid by aminopterin; studies in leukemia patients.
Topics: Aminopterin; Body Fluids; Folic Acid; Folic Acid Antagonists; Leukemia | 1952 |
The nutritional status of folic acid in persons with leukemia and its possible relation to effects of aminopterin therapy.
Topics: Aminopterin; Body Fluids; Folic Acid; Humans; Leukemia; Nutritional Status | 1952 |
Treatment of acute leukemia with anti-folic acid compounds (aninopterin and aminoanfol).
Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Leukemia | 1952 |
Aminopterin (4-amino-pteroyl-glutamic acid) therapy in leukemias.
Topics: Aminopterin; Folic Acid; Glutamates; Leukemia | 1949 |
The induction of resistance to 4-amino-N10-methylpteroylglutamic acid in a strain of transmitted mouse leukemia.
Topics: Amino Acids; Biochemical Phenomena; Folic Acid; Leukemia | 1950 |
The treatment of acute leukemias of childhood with folic acid antagonists.
Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Leukemia | 1950 |
The response of acute leukemia to the administration of the folic acid antagonists, aminopterin and a-methopterin; report of 14 cases.
Topics: Acute Disease; Aminopterin; Folic Acid; Folic Acid Antagonists; Leukemia; Pterins | 1950 |
Observations on acute leukemia in children treated with 4-aminopteroylglutamic acid.
Topics: Acute Disease; Folic Acid; Leukemia | 1950 |
Chemotherapeutic studies of tumors, including leukemia, in children.
Topics: Folic Acid; Humans; Leukemia; Neoplasms | 1950 |
The specificity of 4-aminopteroylglutamic acid (aminopterin) for leukemic hematopoietic tissue.
Topics: Aminopterin; Folic Acid; Leukemia; Sensitivity and Specificity | 1950 |
[Acute leukemia and aminopterin].
Topics: Acute Disease; Aminopterin; Folic Acid; Leukemia | 1950 |
Platelet regeneration during therapy of acute leukemia with folic acid antagonists.
Topics: Acute Disease; Blood; Blood Platelets; Folic Acid; Folic Acid Antagonists; Leukemia; Regeneration | 1950 |
Treatment of leukemia and allied disorders with folic acid antagonists, effect of aminopterin on skeletal lesions.
Topics: Aminopterin; Arylsulfonates; Folic Acid; Folic Acid Antagonists; Leukemia | 1950 |
Aminopterin in leukemia.
Topics: Aminopterin; Folic Acid; Leukemia | 1950 |
The treatment of acute leukemia with the folic acid antagonist, aminopterin.
Topics: Acute Disease; Aminopterin; Blood; Folic Acid; Folic Acid Antagonists; Leukemia | 1950 |
Aminopterin in treatment of leukemia in children; serial aspirations of bone marrow as a guide to management and appraisal of treatment.
Topics: Aminopterin; Bone Marrow; Disease Management; Folic Acid; Leukemia | 1950 |
Roentgenographic changes in long bones of leukemic children treated with "aminopterin.".
Topics: Aminopterin; Bone and Bones; Folic Acid; Leukemia | 1950 |
Aminopterin in the treatment of acute leukaemia.
Topics: Acute Disease; Aminopterin; Folic Acid; Leukemia | 1950 |
[Acute leukemia and folic acid antagonists].
Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Leukemia | 1950 |
Acute leukaemia with a folic acid antagonist.
Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Leukemia | 1950 |
Treatment of leukemia in children with folic acid antagonists.
Topics: Folic Acid; Folic Acid Antagonists; Leukemia | 1950 |
Studies on the mechanism of resistance to the 4-amino antagonists of pteroylglutamic acid in leukemia.
Topics: Folic Acid; Leukemia | 1950 |
[First results of treatment with aminopterin of acute leukemia; preliminary communication].
Topics: Acute Disease; Aminopterin; Communication; Folic Acid; Leukemia | 1950 |
Development of resistance to folic acid antagonists in a transplantable lymphoid leukemia.
Topics: Biochemical Phenomena; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Lymphoid; Transplants | 1950 |
Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Breast Neoplasms; Carrier Proteins; Drug Resistance, Neoplasm; Flow Cytometry; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Leukemia; Methotrexate; Mice; Receptors, Cell Surface; Receptors, Estrogen; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured; Vitamin B Complex | 1991 |
Folate levels and methylation of CDKI proteins.
Topics: Cyclin-Dependent Kinase Inhibitor Proteins; DNA Methylation; Folic Acid; Humans; Leukemia | 2007 |
Observations on the treatment of acute leucemias with analogues of folic acid.
Topics: Acute Disease; Folic Acid; Inorganic Chemicals; Leukemia; Organic Chemicals | 1948 |
Treatment of acute leucemia with aminopterin (4-amino-pteroylglutamic acid).
Topics: Acute Disease; Amino Acids; Aminopterin; Folic Acid; Leukemia | 1948 |
Treatment of chronic leucemia with a folic acid antagonist.
Topics: Chronic Disease; Folic Acid; Folic Acid Antagonists; Humans; Leukemia | 1948 |
Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer.
Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Neoplasms; Vitamin B Complex; Vitamins | 1949 |
The use of folic acid antagonists in the treatment of acute and subacute leukemia.
Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Vitamin B Complex; Vitamins | 1949 |
Studies on the chemotherapy of leukemia; the effect of 4-amino-pteroylglutamic acid and 4-amino-N10-methyl-pteroylglutamic acid on transplanted mouse leukemia.
Topics: Folic Acid; Leukemia | 1949 |
Aminopterin, a folic acid antagonist, in the treatment of leukemia.
Topics: Amino Acids; Aminopterin; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Vitamin B Complex; Vitamins | 1949 |
Use of folic acid antagonist in chronic leukemia.
Topics: Chronic Disease; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Vitamin B Complex; Vitamins | 1949 |
Chemotherapy of leukemia; effect of folic acid derivatives on transplanted mouse leukemia.
Topics: Animals; Folic Acid; Humans; Leukemia; Leukemia, Experimental; Vitamin B Complex; Vitamins | 1949 |
Prevention of chemotherapeutic effects of 4-amino-N10-methyl-pteroylglutamic acid on mouse leukemia by pteroylglutamic acid.
Topics: Amino Acids; Animals; Biomedical Research; Folic Acid; Leukemia; Leukemia, Experimental | 1949 |
The treatment of acute leukemia with folic acid antagonists.
Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Leukemia | 1949 |
Observations on the effect of a folic-acid antagonist on transplantable lymphoid leukemias in mice.
Topics: Animals; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Lymphoid; Mice | 1949 |
Development of macrocytic erythrocytes in leukemic subjects receiving folic acid antagonist, 4-amino-pteroylglutamic acid.
Topics: Amino Acids; Erythrocytes, Abnormal; Folic Acid; Folic Acid Antagonists; Leukemia; Vitamin B Complex; Vitamins | 1949 |
The reduction of folate and of dihydrofolate by homogenates of leukocytes from patients with leukemia or with myeloid metaplasia.
Topics: Biological Assay; Clinical Enzyme Tests; Folic Acid; Humans; In Vitro Techniques; Leukemia; Leukocytes; Methotrexate; Oxidation-Reduction; Primary Myelofibrosis; Tetrahydrofolate Dehydrogenase | 1967 |
Similar specificity of membrane transport for folate analogues and their metabolites by murine and human tumor cells: a clinically directed laboratory study.
Topics: Animals; Biological Transport; Breast Neoplasms; Cell Line; Cell Membrane; Female; Folic Acid; Humans; Kinetics; Leukemia; Leukemia L1210; Neoplasms; Sarcoma 180; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1984 |
Unusual case of acute leukemia. Coexisting acute leukemia and pernicious anemia.
Topics: Acute Disease; Anemia, Pernicious; Bone Marrow; Cell Division; Cystadenocarcinoma; Female; Folic Acid; Hemoglobins; Humans; Leukemia; Melphalan; Middle Aged; Ovarian Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency | 1984 |
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
Topics: Acyltransferases; Animals; Biological Transport, Active; Carrier Proteins; Cell Division; Enzyme Inhibitors; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Leucovorin; Leukemia; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Mice; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Receptors, Cell Surface; Reduced Folate Carrier Protein; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
[Detection of alterations of dihydrofolate reductase gene in folate-resistant leukemia cells by in vitro enzymatic amplification].
Topics: Base Sequence; DNA Probes; Drug Resistance; Folic Acid; Humans; Leukemia; Molecular Sequence Data; Nucleic Acid Hybridization; Point Mutation; Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1993 |
Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues.
Topics: Antineoplastic Agents; Base Sequence; Blotting, Southern; DNA, Neoplasm; Drug Resistance; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Methotrexate; Molecular Sequence Data; Oligonucleotide Probes; Polymerase Chain Reaction; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured | 1993 |
Amplification of the thymidylate synthase gene in an N10-propargyl-5,8-dideazafolic-acid-resistant human leukemia, MOLT-3 cell line developed in pteroylglutamic acid, but not in leucovorin.
Topics: Biological Transport; Drug Resistance; Enzyme Inhibitors; Folic Acid; Gene Amplification; Genes; Humans; Leucovorin; Leukemia; Methotrexate; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
Topics: Affinity Labels; Biological Transport; Blotting, Northern; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Glutamates; Humans; Kinetics; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Pyrimethamine; Pyrimidines; Reduced Folate Carrier Protein; Structure-Activity Relationship; Tetrahydrofolates; Trimetrexate; Tumor Cells, Cultured | 1998 |
Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells.
Topics: 3' Untranslated Regions; Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Division; DNA Primers; DNA, Complementary; DNA, Neoplasm; Folic Acid; Humans; Leukemia; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Reduced Folate Carrier Protein; RNA, Messenger; RNA, Neoplasm; Transfection; Tumor Cells, Cultured | 2000 |
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Blotting, Northern; Blotting, Southern; Blotting, Western; Carrier Proteins; Cell Division; Cell Membrane; Chlorides; DNA Mutational Analysis; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Exons; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Kinetics; Leucovorin; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mutagenesis, Site-Directed; Mutation; Polymorphism, Single-Stranded Conformational; Protein Structure, Secondary; Protein Structure, Tertiary; Quinazolines; Recombinant Proteins; Reduced Folate Carrier Protein; Thymidylate Synthase; Time Factors; Transfection; Trimetrexate; Tumor Cells, Cultured | 2000 |
"Should we treat leuchaemia in children?".
Topics: Acute Disease; Child; Disease Progression; Folic Acid; Humans; Leukemia | 2001 |
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Thymidylate synthetase and 2'-deoxyuridylate form a tight complex in the presence of pteroyltriglutamate.
Topics: Cell Line; Deoxyuracil Nucleotides; Folic Acid; Humans; Kinetics; Lacticaseibacillus casei; Leukemia; Methyltransferases; Protein Binding; Pteroylpolyglutamic Acids; Thymidylate Synthase | 1979 |
Serum folates in man.
Topics: Anemia, Pernicious; Arthritis, Rheumatoid; Biological Assay; Celiac Disease; Enterococcus faecalis; Folic Acid; Formyltetrahydrofolates; Humans; Lacticaseibacillus casei; Leukemia; Pediococcus; Schizophrenia; Tetrahydrofolates | 1977 |
The isolation of dihydrofolate reductases by affinity chromatography on folate-sepharose.
Topics: Animals; Cell Line; Chromatography, Affinity; Folic Acid; Humans; Lacticaseibacillus casei; Leukemia; Leukemia L1210; Leukocytes; Methotrexate; Mice; Sepharose; Tetrahydrofolate Dehydrogenase | 1977 |
Symposium on obstetric hematology.
Topics: Blood; Blood Platelet Disorders; Disseminated Intravascular Coagulation; Female; Folic Acid; Humans; Iron; Leukemia; Lymphoma; Pregnancy; Pregnancy Complications, Hematologic; Reproduction; Thromboembolism | 1979 |
Specific and non-specific folate binding protein in normal and malignant human tissues.
Topics: Adolescent; Adult; Aged; Carrier Proteins; Female; Folic Acid; Gastrointestinal Neoplasms; Humans; Intestinal Mucosa; Leukemia; Leukocytes; Male; Middle Aged | 1978 |
Folate binding protein in myeloproliferative disorders.
Topics: Female; Folic Acid; Humans; Leukemia; Pregnancy; Protein Binding | 1976 |
Biopterin derivatives in human body fluids and tissues.
Topics: Adolescent; Adult; Biological Assay; Biopterins; Body Fluids; Brain Chemistry; Chemical Phenomena; Chemistry; Child; Chromatography, DEAE-Cellulose; Culture Media; Eukaryota; Female; Folic Acid; Humans; Leukemia; Liver; Male; Methotrexate; Middle Aged; Milk, Human; Psoriasis; Pteridines | 1976 |
[Acute or subacute myelofibrosis].
Topics: Acute Disease; Adult; Aged; Alkaline Phosphatase; Bone Marrow Examination; Cell Survival; Erythrocytes; Erythropoiesis; Female; Folic Acid; Humans; Leukemia; Leukocytes; Male; Middle Aged; Primary Myelofibrosis; Uric Acid; Vitamin B 12 | 1976 |
Polyglutamate forms of folate in resting and proliferating mammalian tissues.
Topics: Adolescent; Adult; Aged; Animals; Child; Chromatography, DEAE-Cellulose; Female; Folic Acid; Hepatectomy; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Liver; Liver Regeneration; Male; Middle Aged; Rats | 1975 |
Folate studies. Folate and vitamin B12 values in relation to bone marrow pattern.
Topics: Adolescent; Adult; Age Factors; Aged; Anemia; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Child; Child, Preschool; Erythrocytes; Erythropoiesis; Female; Folic Acid; Folic Acid Deficiency; Hemoglobins; Humans; Infant; Leukemia; Male; Megaloblasts; Middle Aged; Sex Factors; Transferrin; Vitamin B 12; Vitamin B 12 Deficiency | 1975 |
Chronic neurologic disturbance in childhood leukemia.
Topics: Adolescent; Antineoplastic Agents; Child; Cyclophosphamide; Cytarabine; Folic Acid; Humans; Learning Disabilities; Leukemia; Leukemia, Lymphoid; Methotrexate; Movement Disorders; Nervous System Diseases; Prospective Studies; Radiotherapy; Seizures; Time Factors | 1976 |
Cancer chemotherapy: What drugs are available.
Topics: Antibiotics, Antineoplastic; Doxorubicin; Folic Acid; History, 19th Century; Hodgkin Disease; Humans; Leukemia; Neoplasms; Nitrogen Mustard Compounds; Vinca Alkaloids | 1976 |
Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell lines.
Topics: Affinity Labels; Biological Transport, Active; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Leukemia; Methotrexate; Purines; Receptors, Cell Surface; Thymidine; Tumor Cells, Cultured | 1992 |
The role of folates in the development of methotrexate resistance in human leukemia cell line K562.
Topics: Cell Cycle; Drug Resistance; Folic Acid; Humans; Leucovorin; Leukemia; Methotrexate; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1992 |
Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Binding Sites; Cell Division; Crystallization; Drug Design; Escherichia coli; Folic Acid; Humans; Imidazoles; Leukemia; Leukemia L1210; Mice; Molecular Structure; Quinolines; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors.
Topics: Antineoplastic Agents; Biological Transport; Cell Division; Cells, Cultured; Drug Carriers; Folic Acid; Folic Acid Antagonists; Humans; In Vitro Techniques; Leukemia; Methotrexate; Quinazolines; Thymidylate Synthase | 1990 |
Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase.
Topics: Acyltransferases; Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Folic Acid; Humans; Hydroxymethyl and Formyl Transferases; Lacticaseibacillus casei; Leukemia; Leukemia L1210; Mice; Molecular Structure; Phosphoribosylglycinamide Formyltransferase; Purines; Stereoisomerism; Streptococcus; Structure-Activity Relationship; Tumor Cells, Cultured | 1989 |
Cytotoxicity of methotrexate and trimetrexate and its reversal by folinic acid in human leukemic CCRF-CEM cells with carrier-mediated and receptor-mediated folate uptake.
Topics: Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Humans; In Vitro Techniques; Leucovorin; Leukemia; Methotrexate; Quinazolines; Receptors, Cell Surface; Trimetrexate; Tumor Cells, Cultured | 1989 |
Interaction of N-hydroxy(sulfo) succinimide active esters with the reduced folate/methotrexate transport system from human leukemic CCRF-CEM cells.
Topics: Biological Transport; Cell Membrane; Cross-Linking Reagents; Dithiothreitol; Folic Acid; Humans; Leukemia; Methotrexate; Succinimides; Tumor Cells, Cultured | 1989 |
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia; Leukemia L1210; Mice | 1986 |
Effects of folate in culture medium on common fragile sites in lymphocyte chromosomes from normal and leukemic children.
Topics: Acute Disease; Adolescent; Cells, Cultured; Child; Child, Preschool; Chromosome Fragile Sites; Chromosome Fragility; Culture Media; Female; Folic Acid; Humans; Infant; Leukemia; Lymphocytes; Male | 1988 |
Effect of cobalamin inactivation on folate metabolism of leukemic cells.
Topics: Bone Marrow; Cell Line; Deoxyuridine; Female; Folic Acid; Humans; Leukemia; Male; Methotrexate; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12 | 1988 |
[Congenital megaloblastic anemia caused by a deficit of transcobalamin II. Effect of the prolonged administration of folic acid at high dosage].
Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Diagnosis, Differential; Female; Folic Acid; Humans; Infant; Leukemia; Leukemoid Reaction; Transcobalamins | 1987 |
Uracil-uric refractory anemia with peroxidase negative neutrophils.
Topics: Anemia, Hypochromic; Anemia, Macrocytic; Blood Cell Count; Bone Marrow; Child; Chromatography; Chromosomes; Female; Folic Acid; Humans; Leukemia; Neutrophils; Peroxidases; Porphyrins; Staining and Labeling; Succinate Dehydrogenase; Uracil; Uracil Nucleotides; Urine; Vitamin B 12 | 1965 |
Excretion of formiminoglutamic acid in reticulosis and carcinoma.
Topics: Anemia, Macrocytic; Blood Chemical Analysis; FIGLU Test; Folic Acid; Humans; Leukemia; Lymphatic Diseases; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neoplasms; Urine; Vitamin B 12 | 1966 |
[Activity of methionine synthetase (5-methyl-5,6,7,8-tetrahydrofolate: homocysteine methyltransferase) as a proliferation parameter in growing cells].
Topics: Cell Division; Cells, Cultured; Cytarabine; DNA Nucleotidyltransferases; Folic Acid; Humans; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Methionine; Methyltransferases; Prednisolone; Tetrahydrofolates; Thioguanine; Thymidine Kinase; Vincristine | 1973 |
Folates in human serum.
Topics: Administration, Oral; Biological Assay; Celiac Disease; Chromatography, Thin Layer; Enterococcus faecalis; Folic Acid; Humans; Lactobacillus; Leukemia; Pseudomonas; Time Factors | 1974 |
Dyserythropoiesis, refractory anemia, and "preleukemia:" metabolic features of the erythrocytes.
Topics: Adolescent; Adult; Aged; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Child; Child, Preschool; Erythrocyte Count; Erythrocytes; Erythropoiesis; Female; Folic Acid; Glutathione; Hematocrit; Hematologic Diseases; Humans; Leukemia; Male; Middle Aged; Phosphofructokinase-1; Precancerous Conditions | 1973 |
[Biochemistry of normal and leukemic white blood cells].
Topics: Bone Marrow; Bone Marrow Cells; DNA, Neoplasm; Folic Acid; Glycolysis; Humans; Isomerases; Leukemia; Leukocytes; Ligases; Methotrexate; Nucleotides; Oxidoreductases; Phosphoric Monoester Hydrolases; Phosphotransferases; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Transaminases | 1967 |
Serum folate levels in malignant disorders.
Topics: Adolescent; Adult; Anemia; Child; Female; Folic Acid; Hemoglobins; Humans; Leukemia; Male; Middle Aged; Neoplasms | 1974 |
Proceedings: Pharmacokinetics of folates in the rat and man.
Topics: Animals; Arthritis, Rheumatoid; Brain Chemistry; Celiac Disease; Crohn Disease; Folic Acid; Humans; Intestines; Kidney; Kinetics; Leukemia; Liver; Rats; Tetrahydrofolates | 1974 |
Encephalopathy in acute leukaemia associated with methotrexate therapy.
Topics: Acute Disease; Adult; Ataxia; Brain Diseases; Child; Child, Preschool; Cognition Disorders; Electroencephalography; Epilepsy; Female; Folic Acid; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Male; Meninges; Methotrexate; Psychoses, Substance-Induced; Tremor | 1972 |
Megaloblastosis in hematologic malignancy.
Topics: Adult; Aged; Erythrocytes; Folic Acid; Histiocytes; Hodgkin Disease; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Large B-Cell, Diffuse; Middle Aged; Vitamin B 12 | 1973 |
The biochemist's outlook on cancer research.
Topics: Aerobiosis; Animals; Antineoplastic Agents; Biochemistry; Carbon Radioisotopes; Cell Transformation, Neoplastic; DNA Replication; England; Folic Acid; Folic Acid Antagonists; Glycolysis; History, 20th Century; Humans; Isotope Labeling; Lactates; Leukemia; Mice; Neoplasms; Research; Tetrahydrofolates; Thymidine; Thymidylate Synthase; Thymine; United States | 1973 |
Studies on serum folate activity in leukaemia and allied disorders.
Topics: Folic Acid; Humans; Leukemia | 1972 |
Rapid separation of methotrexate from folate reductase.
Topics: Folic Acid; Hematopoietic System; Ion Exchange Resins; Leukemia; Methotrexate; Tetrahydrofolate Dehydrogenase; Time Factors | 1973 |
[B12, folic acid and megaloblastic anemias].
Topics: Anemia, Hemolytic; Anemia, Macrocytic; Anemia, Pernicious; Erythrocytes, Abnormal; Folic Acid; Folic Acid Deficiency; Humans; Leukemia; Liver Cirrhosis; Vitamin B 12; Vitamin B 12 Deficiency | 1974 |
Serum folate and serum vitamin B12 in patients with malignant hematologie diseases.
Topics: Blood; Folic Acid; Hodgkin Disease; Humans; In Vitro Techniques; Leukemia; Leukemia, Myeloid; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Vitamin B 12 | 1965 |
[Formate activation and de novo synthesis of purine nucleotides in leukemia cells and its therapeutic modification by 6-mercaptopurine].
Topics: Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Chromatography, Paper; Folic Acid; Formates; Humans; Leukemia; Leukocytes; Ligases; Mercaptopurine; Nucleosides; Nucleotides; Oxidoreductases; Purines; Tetrahydrofolate Dehydrogenase | 1968 |
A possible unifying principle in the chemotherapy of certain protozoal diseases and of leukemia.
Topics: Amebiasis; Arsenicals; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Trypanosomiasis, African | 1969 |
Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Deoxyuridine; DNA, Neoplasm; Female; Folic Acid; Humans; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium | 1969 |
Leukaemia and pregnancy. A report of five cases and discussion of management.
Topics: Adult; Antineoplastic Agents; Female; Folic Acid; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Pregnancy; Pregnancy Complications, Hematologic; Prenatal Care; Puerperal Disorders | 1968 |
Sideroblastic anaemia and its association with leukaemia and myelomatosis: a report of five cases.
Topics: Aged; Anemia, Hypochromic; Anemia, Sideroblastic; Blood Platelets; Bone Marrow Cells; Erythrocyte Count; Female; Folic Acid; Hemoglobinometry; Humans; Iron; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Middle Aged; Multiple Myeloma; Reticulocytes; Vitamin B 12 | 1971 |
Leukocyte folate activity in patients with leukemia.
Topics: Adult; Aged; Child; Female; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Male; Middle Aged; Pregnancy | 1971 |
Microchromosomes in human preleukemia and leukemia.
Topics: Adult; Aged; Blood Cell Count; Bone Marrow Cells; Cell Division; Chromosome Aberrations; Chromosomes, Human, 1-3; Chromosomes, Human, 13-15; Chromosomes, Human, 16-18; Chromosomes, Human, 19-20; Chromosomes, Human, 21-22 and Y; Chromosomes, Human, 4-5; Chromosomes, Human, 6-12 and X; Clone Cells; Female; Folic Acid; Humans; Karyotyping; Leukemia; Leukocytes; Male; Middle Aged; Vitamin B 12 | 1971 |
[FIGLU (formimino-glutamic acid): urinary excretion in malignant neoplasms in childhood].
Topics: Adolescent; Anemia; Antineoplastic Agents; Child; Child, Preschool; Female; FIGLU Test; Folic Acid; Humans; Infant; Leukemia; Liver Diseases; Male; Neoplasms; Nutrition Disorders | 1967 |
The clinical and experimental studies on the metabolism of folic acid using tritiated folic acid. I. Absorption tests of tritiated folic acid in man.
Topics: Anemia; Chromatography; Cobalt Isotopes; Feces; Folic Acid; Gastrointestinal Diseases; Hematologic Diseases; Humans; Intestinal Diseases; Leukemia; Myelitis; Radiometry; Stomach Diseases; Tritium; Vitamin B 12 | 1968 |
The clinical and experimental studies on the metabolism of folic acid using tritiated folic acid. 3. Plasma clearance in man and organ distribution in rat following intravenous administration of tritiated folic acid.
Topics: Acute Disease; Animals; Body Weight; Bone Marrow; Carbon Tetrachloride; Chronic Disease; Folic Acid; Hematologic Diseases; Humans; Injections, Intravenous; Kidney; Leukemia; Liver; Liver Diseases; Methotrexate; Rats; Spleen; Tritium | 1968 |
[On the determination of folic acid activity of human blood in controls and in different pathological states].
Topics: Adolescent; Adult; Anemia, Hypochromic; Anemia, Pernicious; Bone Marrow Diseases; Diabetes Mellitus; Erythrocytes; Female; Folic Acid; Hematologic Diseases; Humans; Leukemia; Liver Cirrhosis; Lymphatic Diseases; Male; Methods; Middle Aged; Neoplasms; Polycythemia Vera; Vitamin B 12 Deficiency | 1969 |
[Low folic acid diet in malignant tumors].
Topics: Choriocarcinoma; Diet Therapy; Female; Folic Acid; Humans; Leukemia; Neoplasm Metastasis; Neoplasms; Pregnancy | 1969 |
[Does folic acid encourage tumor growth?].
Topics: Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Neoplasms | 1969 |
[Folic acid dependent enzymes and nucleotide synthesis in normal and leukemic leukocytes].
Topics: Antineoplastic Agents; Enzymes; Folic Acid; Hexokinase; Humans; Leukemia; Leukocytes; Ligases; Multiple Myeloma; Nucleotides; Oxidoreductases; Tetrahydrofolate Dehydrogenase | 1965 |