Page last updated: 2024-08-17

folic acid and Leukemia

folic acid has been researched along with Leukemia in 194 studies

Research

Studies (194)

Timeframe	Studies, this research(%)	All Research%
pre-1990	157 (80.93)	18.7374
1990's	10 (5.15)	18.2507
2000's	13 (6.70)	29.6817
2010's	12 (6.19)	24.3611
2020's	2 (1.03)	2.80

Authors

Authors	Studies
Beardsley, GP; Fletcher, SR; Harrington, PJ; Moran, RG; Taylor, EC	1
Cui, B; Hou, X; Liu, N; Qiu, A; Zhuang, S	1
Kanarek, N; Petrova, B	1
Chen, Y; Geng, R; Hu, X; Huang, T; Kang, Y; Liu, X; Ma, Y; Qi, X; Sun, J; Wan, Q; Wu, YZ; Xu, X; Zeng, X; Zhang, G; Zhao, X	1
Chen, YC; Kataoka, K; Kempter, S; Kessel, E; Lee, DJ; Lehto, T; Liu, X; Padari, K; Pooga, M; Rädler, JO; Sheu, MT; Uchida, S; Wagner, E; Yoshinaga, N	1
Bradner, JE; Ferrando, AA; Kitara, S; Kung, AL; Qi, J; Roti, G; Sanchez-Martin, M; Saur Conway, A; Stegmaier, K; Su, A; Varca, AC; Wu, L	1
Chen, J; Davoudi, Z; Li, D; Liao, J; Wang, Q; Wei, X; Xiong, J; Xiong, X; Yin, Y; Yu, X; Zheng, H	1
Abdeen, S; Alexander, P; Bhagat, M; Chavali, M; Praseetha, PK; Rose, PA	1
Chen, X; Chen, Y; Li, S; Ping, Q; Shi, Y; Su, Z; Sun, M; Xiao, Y; Zong, L	1
Holman, CD; Jin, J; Liu, P; Zhang, M	1
Holman, CD; Jin, J; Liu, P; Xie, X; Zhang, M	1
Cachia, D; Chi, L; Cykowski, MD; Dabaja, BS; Daver, N; Dinardo, C; Fuller, G; Garg, N; Jabbour, EJ; Jain, N; Kadia, TM; Kamiya-Matsuoka, C; Kantarjian, HM; Konopleva, M; Milgrom, SA; Ohanian, M; Pemmaraju, N; Pinnix, CC; Smith, GL; Woodman, K	1
HEINLE, RW; WELCH, AD	1
Biswal, BK; Verma, RS	1
Eden, T	1
Carson, WE; Kondadasula, SV; Lee, RJ; Li, H; Lu, Y; Piao, L; Wu, J; Yang, X	1
Cabelof, DC; Patterson, D	1
Bugaj, M; Dzik, JM; Gołos, B; Kusakiewicz-Dawid, A; Pawełczak, K; Rode, W; Rzeszotarska, B; Wińska, P	1
Gifford, AJ; Haber, M; Matherly, LH; Norris, MD; Taub, JW; Whetstine, JR; Witt, TL	1
Assaraf, YG; Bunni, MA; Jansen, G; Liani, E; Rothem, L; Smith, CA	1
Aronheim, A; Assaraf, YG; Rothem, L	1
PAOLINO, W	1
MALLARME, J	1
RITCHIE, GM	1
BROQUIST, HP	1
BAUMANN, CA	1
KIELER, J	1
SPRAY, GH; WITTS, LJ	1
GALARDESCHI, O; SPIGLIATI, P	3
GOLDIN, A; GREENHOUSE, SW; HUMPHREYS, SR; MANTEL, N; VENDITTI, JM	1
JIMENEZ DE ASUA, F	1
BRAHIN, C; KRIM, M; MEYER, LM; RITZ, N	1
BURCHENAL, JH; ELLISON, RR; KARNOFSKY, DA; MURPHY, ML	1
BURCHENAL, JH	2
CONSOLI, G	1
DENNIS, D; GOLDIN, A; HUMPHREYS, SR; MANTEL, N; VENDITTI, JM	1
RAUSCH, F	1
HAEHNER, E; LOZANO, R; LUDES, H	1
FISCHER, GA; WELCH, AD	1
GOLDIN, A; HUMPHREYS, ST; MANTEL, N; VENDITTI, JM	1
JOSKE, RA; MACKINNON, NL; PITNEY, WR	1
BEARD, D; BEARD, JW; BEAUDREAU, GS; BECKER, C; CASTLE, W; GIBSON, BW	1
LYNCH, TJ; MOLONEY, WC	1
BRODY, JI; MCKENZIE, D	1
SLAVIK, K; SOCHMAN, J; SOUCEK, J	1
WILMANNS, W	4
FELDMAN, BH; SCHULANER, FA	1
BERLIN, NI; FREIREICH, EJ; HERTZ, R; LIPSETT, MB; MEAD, JA; RALL, D; VANSCOTT, E	1
JAENICKE, L; WILMANNS, W	2
SHARP, AA	1
MISRA, DK	1
GIRDWOOD, RH; KERSHAW, PW	1
CHALMERS, TM; MCCARTHY, DD	1
MOTYCKA, K; SLAVIK, K; SOUCEK, J	1
DUPREE, LT; SANFORD, KK	1
JIRASEK, A; JIRASEK, J; MOTYCKA, K; SLAVIK, K; SOUCEK, J	1
HOGAN, JA; MANIATIS, A; MOLONEY, WC	1
MACGIBBON, BH; MOLLIN, DL	1
COX, RP; FRIEND, C; HADDAD, JR; SILBER, R	1
ROSE, DP	1
EINHORN, J; LAGERLOEF, B; RAO, PB; REIZENSTEIN, PG	1
CRAWFORD, EJ; FRIEDKIN, M; GOLDIN, A; HUMPHREYS, SR; KASHKET, ER	1
ACEVEDO, G; MAUER, AM	1
O'BRIEN, JS; WALSH, JR	1
MOORE, AE; POGO, BG	1
BRIGGS, GM; POTTER, M	1
BELL, M; CHAPMAN, JB; SKIPPER, HE	1
BOCK, G; MEYER, LM; MILLER, FR; ROWEN, MJ; RUTZKY, J	1
HANLON, DG; MASON, HL; STICKNEY, JM	1
BIEDLER, JL; BURCHENAL, JH; MEIGS, GM; WEBBER, LF	1
LAW, LW	1
JOHNSON, EP	1
BASERGA, A	1
MEYER, LM; RUTZKY, J	1
BETHELL, FH; BIRD, OD; SWENDSEID, ME	1
EARLE, AM; LAWSON, WG; REILLY, WA	1
BARTA, I	1
BETHELL, FH; MILLER, S; SWANSON, AL; SWENDSEID, ME	1
BETHELL, FH; MEYERS, MC; SWANSON, AL; SWENDSEID, ME	1
BOCK, G; BRAHIN, CM; JACOBSON, J; KRIM, M; MEYER, LM; RITZ, ND; SAWITSKY, A; SCHWARTZ, SO	1
Lightfoot, TJ; Roman, E	1
CARROLL, GJ; HUNTER, OB	1
BURCHENAL, JH; ROBINSON, E	1
HEINLE, RW; KARPINSKI, FE; WEBER, EJ	1
BRADFORD, GT; SACKS, MS; SCHOENBACH, EB	1
HAGEDORN, AB; MILLS, SD; STICKNEY, JM	1
FARBER, S	2
NOLAN, CW; RISER, WH; SKIPPER, HE	1
SOTO, AR	1
WILSON, SJ	1
SILVERMAN, FN	2
SHAFIK ABBASY, A	1
McCALL, FC; SCHERER, JH	1
BELL, WR; SMITH, CH	1
DACIE, JV; DRESNER, E; MOLLIN, DL; WHITE, JC	1
DUBOIS-FERRIERE, H	1
McNEIL, DL	1
CASSIDY, JE; CROWELL, WM; JUDGE, DF; LEYVA, FR; RICE, EC; TROENDLE, FJ; VADEN, EB	1
MARMONT, A	1
BOYLE, PJ; LAW, LW	1
Gao, XN; Tang, SQ	1
Cowan, KH; Dixon, KH; Eng, SC; Trepel, JB	1
Barragan, E; Bolufer, P; Cervera, J; Collado, M; López, JA; Sanz, MA	1
Barale, R; Buda, G; Galimberti, S; Maggini, V; Petrini, M; Rossi, AM	1
HOLT, C; JACOBSON, W; LEVIN, WC	1
ALT, H; PIERCE, M	1
AXELROD, AR; BERMAN, L	2
DAMESHEK, W	1
BURCHENAL, JH; BURCHENAL, JR	1
FINK, H; MEYER, LM	1
BURCHENAL, JH; JOHNSTON, SF	1
BURCHENAL, JH; KUSHIDA, MN	1
MILLS, SD; STICKNEY, JM	1
DUNN, TB; LAW, LW	1
BOSSI, C; COXSEY, L; WILSON, SJ	1
Hall, TC; Roberts, D	1
Ahmed, T; DeGraw, JI; Moccio, DM; Piper, JR; Samuels, LL; Sirotnak, FM; Yagoda, A	1
Spivak, JL; Vogelsang, GB	1
Boyle, FT; Forsch, RA; Hynes, JB; Jackman, AL; Kathmann, I; Peters, GJ; Pinedo, HM; Rosowsky, A; Schornagel, JH; Westerhof, GR	1
Ando, Y; Miyachi, H; Takemura, Y	1
Ando, K; Ando, Y; Kobayashi, H; Miyachi, H; Takemura, Y	1
Ando, Y; Kobayashi, H; Miyachi, H; Takemura, Y	1
Assaraf, YG; Bunni, M; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Schornagel, JH; Sprecher, H	1
Assaraf, YG; Drori, S; Goldman, ID; Jansen, G; Shemer, G; Sprecher, H	1
Assaraf, YG; Drori, S; Jansen, G; Mauritz, R; Peters, GJ	1
Spiers, AS	1
Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH	1
Danenberg, PV; Lockshin, A	1
Blair, JA; Cooke, WT; Leeming, RJ; Melikian, V; Thien, KR	1
Henderson, GB; Russell, A; Singh, P; Whiteley, JM; Zevely, EM	1
Ambrosetti, A; Bambara, LM; Corrocher, R; De Sandre, G; Hoffbrand, AV; Pachor, ML	1
Girdwood, RH	1
Bambara, LM; Corrocher, R; De Sandre, G; Pachor, ML; Perona, G; Pizzolo, G	1
Blair, JA; Leeming, RJ; Melikian, V; O'Gorman, DJ	1
Bernard, J; Brière, J; Brière, JF; Castro-Malaspina, H	1
Hoffbrand, AV; Lavoie, A; Parsa, K; Tripp, E	1
Magnus, EM	2
Aspnes, GT; Kalavsky, SM; Kammerer, BL; Klatskin, EH; McIntosh, S; O'Brien, RT; Pearson, HA; Snead, C	1
Carter, SK; Kershner, LM	1
Freisheim, JH; Jansen, G; McAlinden, TP; Prasad, KM; Ratnam, M; Schornagel, JH; Westerhof, GR; Williams, FE	1
Ando, Y; Miyachi, H; Scanlon, KJ; Takemura, Y	1
Fuhry, MA; Janson, CA; Jordan, SR; Matthews, DA; Nguyen, D; Pino, MJ; Reich, SH; Smith, WW; Webber, S; Welsh, KM	1
Jackman, AL; Jansen, G; Newell, DR; Rijksen, G; Schornagel, JH; Westerhof, GR	1
Duch, DS; Edelstein, MP; Ferone, R; Gaumont, Y; Kisliuk, RL; Murthy, BR; Nair, MG; Patil, SD; Thorndike, J	1
Jansen, G; Rijksen, G; Schornagel, JH; van der Veer, LJ; Westerhof, GR	1
Jansen, G; Rijksen, G; Schornagel, JH; Westerhof, GR	1
Keyomarsi, K; Moran, RG	1
Chen, AT; Green, RJ; Phillips, DL; Ragab, AH; Reidy, JA	1
Abels, J; Ermens, AA; Kroes, AC; Lindemans, J; Schoester, M; van Lom, K	1
Vives Corrons, JL; Vives Mañé, J	1
Arakawa, T; Chiba, R; Chida, N; Hayashi, T; Kakizaki, R; Konno, T; Wada, Y	1
Israëls, MC; Noeypatimanond, S; Watson-Williams, EJ	1
Jaenicke, L; Sauer, H; Wilmanns, W; Wilms, K	1
Valencia, R	1
Blair, JA; Cooke, WT; Leeming, RJ; Melikian, V; Ratanasthien, K	1
Konrad, PN; Paglia, DE; Valentine, WN	1
Gupta, OP	1
Beavon, JR; Blair, JA; Dransfield, E; Leeming, RJ; Ratanasthien, K; Staff, FJ	1
Harris, RF; Innes, EM; Kay, HE; Knapton, PJ; O'Sullivan, JP; Schwartz, FC; Stuart, J; Thompson, EN; Wells, DG	1
Bloom, AL; Jacobs, A	1
Bart, JB	1
Friedkin, M	1
Banerjee, DK; Basu, AK; Maitra, A	1
Rothenberg, SP	1
Bertino, JR; Hillcoat, BL	1
Reizenstein, P	1
Katayama, N; Kawakita, Y; Yamazaki, T	1
Baker, H; Gilbert, HS; Hoogstraten, B	1
Jondorf, WR	1
Bertino, JR; Hryniuk, WM	1
Nicholson, HO	1
Catovsky, D; Dacie, JV; Hoffbrand, AV; Shaw, MT	1
Gabriel, FD; Rosner, F	1
Hoagland, HC; Linman, JW; Pierre, RV	1
Benso, L; Bonenti, G; Nigro, N	1
Yoshino, T	2
Karlin, R	1
Schmidt, CG	1
Begemann, H	1
Grignani, F; Larizza, P	1

Reviews

13 review(s) available for folic acid and Leukemia

Article	Year
Potential Benefits and Pitfalls of Histidine Supplementation for Cancer Therapy Enhancement. The Journal of nutrition, 2020, 10-01, Volume: 150, Issue:Suppl 1 Topics: Animals; Dietary Supplements; Folic Acid; Formiminoglutamic Acid; Histidine; Humans; Leukemia; Methotrexate; Neoplasms	2020
Aetiology of childhood leukaemia. Cancer treatment reviews, 2010, Volume: 36, Issue:4 Topics: Alcohol Drinking; Background Radiation; Child; Electromagnetic Fields; Folic Acid; Genetic Predisposition to Disease; Humans; Incidence; Leukemia; Seasons; Smoking	2010
Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging. Mechanisms of ageing and development, 2012, Volume: 133, Issue:4 Topics: Aging; Animals; DNA Polymerase beta; DNA Repair; Down Syndrome; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Genomic Instability; Haploinsufficiency; Humans; Leukemia; MicroRNAs; Oxidative Stress; Phenotype	2012
[FOLIC ACID METABOLISM AND ONE-CARBON UNITS]. Klinische Wochenschrift, 1963, Nov-01, Volume: 41 Topics: Avitaminosis; Biochemical Phenomena; Carbon; Coenzymes; Escherichia coli; Folic Acid; Folic Acid Antagonists; Hematology; Humans; Leukemia; Metabolism; Neoplasms	1963
Causes of childhood leukaemia and lymphoma. Toxicology and applied pharmacology, 2004, Sep-01, Volume: 199, Issue:2 Topics: Animals; Carcinogens; Child; Diet; Environmental Exposure; Fertility; Folic Acid; Humans; Infant; Infant Food; Leukemia; Leukemia, Radiation-Induced; Life Style; Lymphoma	2004
[Folate receptor and its application in the selective receptor-mediated targeting therapy of tumor cells--review]. Zhongguo shi yan xue ye xue za zhi, 2005, Volume: 13, Issue:5 Topics: Antineoplastic Agents; Carrier Proteins; Drug Delivery Systems; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Leukemia; Receptors, Cell Surface; Tretinoin; Tumor Cells, Cultured	2005
Influence of genetic polymorphisms on the risk of developing leukemia and on disease progression. Leukemia research, 2006, Volume: 30, Issue:12 Topics: Animals; Disease Progression; DNA Repair; Enzymes; Folic Acid; Genetic Variation; Humans; Leukemia; Polymorphism, Genetic; Risk Factors	2006
Drug-induced anaemias. Drugs, 1976, Volume: 11, Issue:5 Topics: Anemia; Anemia, Aplastic; Anemia, Megaloblastic; Anemia, Sideroblastic; Anticonvulsants; Bone Marrow; Chloramphenicol; Chromosomes; Contraceptives, Oral; Drug Hypersensitivity; Erythrocytes; Folic Acid; Folic Acid Antagonists; Hemorrhage; Humans; Leukemia; Trimethoprim	1976
[Control of cellular division by vitamin B 12 and folates]. Journal de physiologie, 1974, Volume: 69, Issue:1 Topics: Anemia, Macrocytic; Anemia, Pernicious; Animals; Cell Division; Euglena gracilis; Folic Acid; Folic Acid Deficiency; Humans; Leukemia; Methylation; Nucleic Acids; Nucleotides; Vitamin B 12; Vitamin B 12 Deficiency	1974
Advances in the treatment of blood disorders. The Practitioner, 1972, Volume: 209, Issue:252 Topics: Anemia, Aplastic; Anemia, Hypochromic; Anemia, Macrocytic; Antibodies, Anti-Idiotypic; Antineoplastic Agents; Blood Transfusion; Child; Disseminated Intravascular Coagulation; Erythroblastosis, Fetal; Female; Folic Acid; Hematologic Diseases; Humans; Hydroxocobalamin; Infant; Infant, Newborn; Iron; Leukemia; Multiple Myeloma; Polycythemia Vera; Pregnancy; Purpura, Thrombocytopenic; Thrombosis	1972
Regulation of dihydrofolate reductase and other folate-requiring enzymes. Advances in enzyme regulation, 1968, Volume: 6 Topics: Alcohol Oxidoreductases; Animals; Enzyme Induction; Erythrocytes; Escherichia coli; Folic Acid; Folic Acid Antagonists; Formates; Guinea Pigs; Homocysteine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leukemia; Leukocytes; Ligases; Methotrexate; Oxidoreductases; Rats; Salmonella typhimurium; Serine; Streptococcus; Tetrahydrofolate Dehydrogenase	1968
[Leukemia and nutrition--pathologic metabolism and distribution of protein, fat, folic acid, and iron]. Nordisk medicin, 1970, Jan-15, Volume: 83, Issue:3 Topics: Aged; Amino Acids; Asparagine; Fats; Folic Acid; Humans; Iron; Leukemia; Lymphoma; Middle Aged	1970
[Recent progress in hematology]. Naika. Internal medicine, 1971, Volume: 27, Issue:1 Topics: Anemia, Macrocytic; Complement System Proteins; Erythropoietin; Folic Acid; Humans; Leukemia; Vitamin B 12	1971

Other Studies

181 other study(ies) available for folic acid and Leukemia

Article	Year
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin. Journal of medicinal chemistry, 1985, Volume: 28, Issue:7 Topics: Amide Synthases; Aminopterin; Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia L1210; Ligases; Male; Methotrexate; Tetrahydrofolates; Thymidylate Synthase	1985
Pharmacological inhibition of the mixed lineage leukemia 1-menin interaction aggravates acute kidney injury induced by folic acid and ischemia-reperfusion in mice. American journal of physiology. Renal physiology, 2023, 11-01, Volume: 325, Issue:5 Topics: Acute Kidney Injury; Animals; Creatinine; ErbB Receptors; Folic Acid; Histones; Ischemia; Leukemia; Lysine; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein; Reperfusion; Reperfusion Injury; Transcription Factors	2023
Multicolor bioimaging with biosynthetic zinc nanoparticles and their application in tumor detection. Scientific reports, 2017, 03-27, Volume: 7 Topics: Animals; Cell Line, Tumor; Cell Membrane; Coloring Agents; Fluorescence; Folic Acid; Humans; Leukemia; Mice; Mice, Nude; Nanoparticles; Sulfides; Zinc	2017
Systemic Delivery of Folate-PEG siRNA Lipopolyplexes with Enhanced Intracellular Stability for In Vivo Gene Silencing in Leukemia. Bioconjugate chemistry, 2017, 09-20, Volume: 28, Issue:9 Topics: Animals; Cell Line, Tumor; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Kinesins; Leukemia; Mice, Nude; Polyethylene Glycols; RNA Interference; RNA Stability; RNA, Small Interfering; RNAi Therapeutics	2017
Leukemia-specific delivery of mutant NOTCH1 targeted therapy. The Journal of experimental medicine, 2018, 01-02, Volume: 215, Issue:1 Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Line, Tumor; Disease Models, Animal; Drug Delivery Systems; Endocytosis; Folate Receptor 2; Folic Acid; Gene Expression; Humans; Leukemia; Mice; Mutation; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Protein Binding; Receptor, Notch1; Signal Transduction; Thapsigargin; Xenograft Model Antitumor Assays	2018
Folate Receptor-Targeted and GSH-Responsive Carboxymethyl Chitosan Nanoparticles Containing Covalently Entrapped 6-Mercaptopurine for Enhanced Intracellular Drug Delivery in Leukemia. Marine drugs, 2018, Nov-08, Volume: 16, Issue:11 Topics: Animals; Antimetabolites, Antineoplastic; Chemoradiotherapy; Drug Carriers; Drug Liberation; Drug Screening Assays, Antitumor; Drug Stability; Fibroblasts; Folate Receptors, GPI-Anchored; Folic Acid; Glutathione; HL-60 Cells; Humans; Leukemia; Mercaptopurine; Mice; Microscopy, Electron, Transmission; Nanoparticles	2018
Drug embedded PVP coated magnetic nanoparticles for targeted killing of breast cancer cells. Technology in cancer research & treatment, 2013, Volume: 12, Issue:5 Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Cell Line, Tumor; Chemistry, Pharmaceutical; Coated Materials, Biocompatible; Drug Delivery Systems; Epirubicin; Female; Folic Acid; Humans; Leukemia; Lung Neoplasms; Magnetite Nanoparticles; Male; Pharmaceutic Aids; Povidone; Prostatic Neoplasms; Spectroscopy, Fourier Transform Infrared	2013
Multistep targeted nano drug delivery system aiming at leukemic stem cells and minimal residual disease. Molecular pharmaceutics, 2013, Jun-03, Volume: 10, Issue:6 Topics: Animals; Antineoplastic Agents; Bone Marrow; Cell Line, Tumor; Drug Delivery Systems; Durapatite; Folic Acid; Humans; Leukemia; Leukocytes; Mice; Mitoxantrone; Neoplasm, Residual; Neoplastic Stem Cells; Polyethylene Glycols; Rats	2013
Diet and risk of adult leukemia: a multicenter case-control study in China. Cancer causes & control : CCC, 2015, Volume: 26, Issue:8 Topics: Adult; Aged; Animals; Ascorbic Acid; Carotenoids; Case-Control Studies; China; Diet; Dietary Fiber; Feeding Behavior; Female; Folic Acid; Food; Humans; Leukemia; Logistic Models; Male; Middle Aged; Niacin; Odds Ratio; Riboflavin; Risk Factors; Surveys and Questionnaires; Thiamine; Vitamins	2015
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase, dietary folate intake, and the risk of leukemia in adults. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:3 Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Diet; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leukemia; Leukemia, Myeloid; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Sex Factors; Surveys and Questionnaires; Thymidylate Synthase; Young Adult	2016
Dorsal column myelopathy after intrathecal chemotherapy for leukemia. American journal of hematology, 2017, Volume: 92, Issue:2 Topics: Antimetabolites, Antineoplastic; Diagnosis, Differential; Electronic Health Records; Female; Folic Acid; Homocysteine; Humans; Injections, Spinal; Leukemia; Magnetic Resonance Imaging; Male; Methotrexate; Spinal Cord Diseases; Subacute Combined Degeneration	2017
Experiments with pteroylglutamic acid and pteroylglutamic acid deficiency in human leukemia. The Journal of clinical investigation, 1948, Volume: 27, Issue:4 Topics: Folic Acid; Leukemia	1948
Differential usage of the transport systems for folic acid and methotrexate in normal human T-lymphocytes and leukemic cells. Journal of biochemistry, 2009, Volume: 146, Issue:5 Topics: Antibodies; Biological Transport; Buffers; Carrier Proteins; Cell Line, Tumor; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression Regulation; Humans; Hydrogen-Ion Concentration; Immunohistochemistry; Ions; Leukemia; Membrane Transport Proteins; Methotrexate; Mitomycin; Phosphates; Receptors, Cell Surface; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; Sulfasalazine; Sulfates; T-Lymphocytes; Time Factors; Verapamil	2009
Folate-immunoglobulin G as an anticancer therapeutic antibody. Bioconjugate chemistry, 2010, May-19, Volume: 21, Issue:5 Topics: Animals; Carrier Proteins; Cell Line, Tumor; Cell Survival; Cytokines; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Immunoglobulin G; Leukemia; Liposomes; Mice; Mice, Inbred DBA; Receptors, Cell Surface	2010
Synthesis and biological activity of N(alpha)-[4-[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N-propargylamino]phenylacetyl]-L-glutamic acid. Acta biochimica Polonica, 2002, Volume: 49, Issue:1 Topics: Animals; Folic Acid; Glutamic Acid; Leukemia; Mice; Rats	2002
Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells. Leukemia, 2002, Volume: 16, Issue:12 Topics: Amino Acid Substitution; Antimetabolites, Antineoplastic; Bone Marrow Cells; Carrier Proteins; Child; Drug Resistance, Neoplasm; Folic Acid; Humans; Kinetics; Leukemia; Membrane Transport Proteins; Methotrexate; Point Mutation; Protein Structure, Tertiary; Reduced Folate Carrier Protein; Transfection; Tumor Cells, Cultured	2002
Loss of folylpoly-gamma-glutamate synthetase activity is a dominant mechanism of resistance to polyglutamylation-dependent novel antifolates in multiple human leukemia sublines. International journal of cancer, 2003, Feb-20, Volume: 103, Issue:5 Topics: Base Sequence; Binding Sites; Biological Transport; Blotting, Northern; Blotting, Western; Cell Division; DNA Primers; Down-Regulation; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Genes, Dominant; Humans; Leukemia; Mutation; Peptide Synthases; Polyglutamic Acid; Polymorphism, Single-Stranded Conformational; Protein Conformation; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured	2003
Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells. The Journal of biological chemistry, 2003, Mar-14, Volume: 278, Issue:11 Topics: Alleles; Biological Transport; Blotting, Western; Carrier Proteins; Cell Division; Cell Nucleus; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; Folic Acid; Folic Acid Antagonists; Gene Silencing; Genes, Reporter; Genetic Vectors; Humans; Leukemia; Leukemia, T-Cell; Luciferases; Membrane Transport Proteins; Oligonucleotides; Promoter Regions, Genetic; Protein Binding; Protein Isoforms; Reduced Folate Carrier Protein; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sp1 Transcription Factor; Sp3 Transcription Factor; Transcription Factors; Transcription, Genetic; Transfection; Tumor Cells, Cultured	2003
[Folic acid antagonists in therapy of leukemia and tumors; problem of resistance and relations with the citrovorum factor]. Minerva medica, 1952, Jun-14, Volume: 43, Issue:48 Topics: Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Leukemia; Neoplasms	1952
[Aminopterin in the treatment of malignant leukemia and its antidote--folic acid]. Le Sang, 1952, Volume: 23, Issue:7 Topics: Aminopterin; Antidotes; Folic Acid; Folic Acid Antagonists; Leukemia	1952
Extensive myeloid response during folic acid therapy in megaloblastic anaemia of pregnancy. Journal of clinical pathology, 1952, Volume: 5, Issue:4 Topics: Anemia; Anemia, Macrocytic; Anemia, Megaloblastic; Female; Folic Acid; Humans; Leukemia; Pregnancy	1952
Role of folic acid and citrovorum factor in metabolic processes and their relation to cancer. Texas reports on biology and medicine, 1952, Volume: 10, Issue:4 Topics: Antimetabolites; Biochemical Phenomena; Folic Acid; Leucovorin; Leukemia; Neoplasms	1952
Citrovorum factor; nutritional aspects, associations with leukemia and anemia. Journal of the American Dietetic Association, 1953, Volume: 29, Issue:6 Topics: Anemia; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Leukemia	1953
Combination therapy of chloroleukemia in mice with aminopterin and citrovorum factor. Acta haematologica, 1953, Volume: 10, Issue:3 Topics: Aminopterin; Animals; Combined Modality Therapy; Folic Acid; Leucovorin; Leukemia; Mice; Sarcoma, Myeloid	1953
The utilisation of folic acid in anaemia and leukaemia. Clinical science, 1953, Volume: 12, Issue:4 Topics: Anemia; Folic Acid; Humans; Leukemia	1953
[Therapeutic experimentation with citrovorum factor in acute leukemia; folic acid deficiency as the etiopathogenic factor essential in transformation of chronic stage of leukemia into acute]. Rivista critica di clinica medica, 1953, Jun-30, Volume: 52, Issue:3 Topics: Acute Disease; Antimetabolites; Folic Acid; Folic Acid Deficiency; Leucovorin; Leukemia; Leukemia, Myeloid	1953
[Studies on interference of aminopterin and folic acid with process of maturation of leukemic cell]. Rivista critica di clinica medica, 1953, Volume: 52, Issue:4 Topics: Aminopterin; Folic Acid; Humans; Leukemia	1953
Estimation of the antileukemic potency of the antimetabolite aminopterin, administered alone and in combination with citrovorum factor or folic acid. Cancer research, 1953, Volume: 13, Issue:12 Topics: Aminopterin; Antimetabolites; Folic Acid; Leucovorin; Leukemia; Leukemia, Lymphoid; Lymphatic Vessels	1953
[Considerations on the treatment of acute leukemias with special reference to the action of citrovorum factor, leukovorine]. Le Sang, 1953, Volume: 24, Issue:7 Topics: Acute Disease; Antimetabolites; Folic Acid; Leucovorin; Leukemia	1953
Remission in chronic myelocytic leukemia during folic acid therapy. New York state journal of medicine, 1954, May-01, Volume: 54, Issue:9 Topics: Folic Acid; Humans; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid	1954
Clinical effects of the dichloro and monochlorophenyl analogues of diamino pyrimidine: antagonists of folic acid. The Journal of clinical investigation, 1954, Volume: 33, Issue:10 Topics: Folic Acid; Humans; Leukemia; Pyrimidines	1954
Clinical effects of analogs of folic acid, purines, pyrimidines, and amino acids. Federation proceedings, 1954, Volume: 13, Issue:3 Topics: Amino Acids; Folic Acid; Folic Acid Antagonists; Humans; Inorganic Chemicals; Leukemia; Purines; Pyrimidines	1954
[Associated citrovorum factor-aminopterin treatment in acute leukemia]. Le Sang, 1955, Volume: 26, Issue:4 Topics: Acute Disease; Aminopterin; Antimetabolites; Folic Acid; Leucovorin; Leukemia	1955
Studies on the management of mouse leukemia (L1210) with antagonists of folic acid. Cancer research, 1955, Volume: 15, Issue:11 Topics: Animals; Disease Management; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Experimental	1955
[Anaphylactic shock after folic acid therapy]. Therapie der Gegenwart, 1956, Volume: 95, Issue:2 Topics: Anaphylaxis; Folic Acid; Humans; Hypersensitivity; Immune System Diseases; Leukemia; Leukemia, Lymphoid	1956
[Peroral folic acid loading test in leukemia and Hodgkin's disease]. Munchener medizinische Wochenschrift (1950), 1956, Apr-06, Volume: 98, Issue:14 Topics: Blood Gas Analysis; Folic Acid; Hodgkin Disease; Humans; Leukemia	1956
[Recurrence of acute phase in leukemia; functional recuperation of normal granulopoiesis with therapeutic use of citrovorum factor]. Rivista critica di clinica medica, 1955, Volume: 55, Issue:1-6 Topics: Folic Acid; Leucovorin; Leukemia; Neoplasms; Recurrence	1955
Effect of citrovorum factor and peptones on mouse leukemia cells L-5178 in tissue culture. Science (New York, N.Y.), 1957, Nov-15, Volume: 126, Issue:3281 Topics: Animals; Folic Acid; Leucovorin; Leukemia; Neoplasms, Experimental; Peptones; Research Design; Tissue Culture Techniques	1957
Comparison of the relative effectiveness of folic acid congeners against advanced leukemia in mice. Journal of the National Cancer Institute, 1957, Volume: 19, Issue:6 Topics: Animals; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Mice	1957
Folic acid and other absorption tests in lymphosarcoma, chronic lymphocytic leukaemia, and some related conditions. Journal of clinical pathology, 1960, Volume: 13 Topics: Animals; Folic Acid; Hodgkin Disease; Humans; Intestines; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Lymphocytes; Lymphoma; Lymphoma, Non-Hodgkin	1960
Virus of avian myeloblastosis. XXII. Influence of folic acid and other factors on growth of myeloblasts and virus synthesis in tissue culture. Journal of the National Cancer Institute, 1962, Volume: 29 Topics: Folic Acid; Granulocyte Precursor Cells; Humans; Leukemia; Research Design; Viruses	1962
Observations on serum B-12 and folate activity in normal and leukemic rats. Blood, 1963, Volume: 21 Topics: Animals; Folic Acid; Hematinics; Leukemia; Leukemia, Experimental; Rats; Vitamin B 12; Vitamin B Complex	1963
Synergistic toxicity of triethylene thiophosphoramide and folic acid in the IRC-741 leukemia. Cancer research, 1963, Volume: 23 Topics: Folic Acid; Leukemia; Leukemia, Experimental; Thiotepa	1963
Activity changes of some enzyme systems interferring into the metabolism of folic acid in the livers of mice in the course of LaHVUFB leucaemia. Neoplasma, 1963, Volume: 10 Topics: Animals; Folic Acid; Folic Acid Antagonists; Fructose-Bisphosphate Aldolase; Leukemia; Leukemia, Experimental; Liver; Mice; Oxidoreductases; Transferrin	1963
[On the mechanism of action of folic acid and purine antagonists in the treatment of acute leukemias]. Folia haematologica; internationales Magazin fur Blutforschung, 1963, Volume: 7 Topics: Antimetabolites; Folic Acid; Leukemia; Purines	1963
[Determination, properties and significance of dihydrofolic acid reductase in the white blood cells in leukemia]. Klinische Wochenschrift, 1962, May-15, Volume: 40 Topics: Folic Acid; Humans; Leukemia; Leukocyte Count; Leukocytes; Oxidoreductases	1962
INTUSSUSCEPTION AS A CAUSE OF DEATH IN ACUTE LEUKEMIA; REPORT OF A CASE. The Journal of pediatrics, 1963, Volume: 63 Topics: Cause of Death; Child; Death, Sudden; Folic Acid; Humans; Intussusception; Leukemia; Leukemia, Lymphoid; Lymphocytes; Lymphoma, Non-Hodgkin; Mercaptopurine; Steroids	1963
FOLIC ACID ANTAGONIST. EFFECTS ON THE CELL AND THE PATIENT. COMBINED CLINICAL STAFF CONFERENCE AT THE NATIONAL INSTITUTES OF HEALTH. Annals of internal medicine, 1963, Volume: 59 Topics: Biochemical Phenomena; Biochemistry; Bone Marrow; Child; Choriocarcinoma; Epithelium; Female; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Metabolism; National Institutes of Health (U.S.); Pathology; Pharmacology; Pregnancy; Toxicology; Trophoblastic Neoplasms; United States	1963
[THE SIGNIFICANCE OF THE FOLIC ACID METABOLISM FOR THE NORMAL AND PATHOLOGICAL MATURATION OF BLOOD CELLS]. Klinische Wochenschrift, 1963, Nov-15, Volume: 41 Topics: Blood Cells; Folic Acid; Humans; Isomerases; Leucovorin; Leukemia; Mercaptopurine; Metabolism; Methotrexate; Oxidoreductases	1963
MACROCYTIC ANAEMIA, LEUKAEMIA AND HAEMOGLOBINOPATHIES. Transactions of the ophthalmological societies of the United Kingdom, 1963, Volume: 83 Topics: Anemia, Macrocytic; Avitaminosis; Eye Manifestations; Folic Acid; Hemoglobinopathies; Hemoglobins; Hemoglobins, Abnormal; Leukemia; Thalassemia; Vitamin B 12 Deficiency	1963
A DIRECT ASSAY FOR DIHYDROFOLATE REDUCTASE IN HUMAN LEUKOCYTES. Blood, 1964, Volume: 23 Topics: Animals; Chemistry Techniques, Analytical; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Leukemia, Myeloid; Leukocytes; Methotrexate; Mice; Microchemistry; NADP; Neoplasms; Oxidoreductases; Research; Spectrophotometry; Tetrahydrofolate Dehydrogenase	1964
SOME INVESTIGATIONS OF FOLIC-ACID DEFICIENCY. Scottish medical journal, 1964, Volume: 9 Topics: Anemia; Anemia, Hemolytic; Anemia, Macrocytic; Anticonvulsants; Biomedical Research; Blood Chemical Analysis; Female; Folic Acid; Folic Acid Deficiency; Geriatrics; Glutamates; Histidine; Leukemia; Liver Diseases; Metabolism; Neoplasms; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Urine; Vitamin B 12 Deficiency	1964
HEMATOLOGICAL COMPLICATIONS OF PHENYLBUTAZONE THERAPY: REVIEW OF THE LITERATURE AND REPORT OF TWO CASES. Canadian Medical Association journal, 1964, May-02, Volume: 90 Topics: Adrenocorticotropic Hormone; Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Arthritis; Arthritis, Rheumatoid; Blood Platelet Disorders; Blood Transfusion; Folic Acid; Hematology; Humans; Leukemia; Leukocyte Count; Leukopenia; Phenylbutazone; Prednisolone; Thrombocytopenia; Toxicology	1964
ACTIVITY CHANGES OF SOME ENZYME SYSTEMS INTERFERING IN FOLIC ACID METABOLISM IN THE COURSE OF MOUSE LEUKAEMIA OF AKR-STRAIN. Neoplasma, 1964, Volume: 11 Topics: Aldehyde-Lyases; Animals; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Experimental; Liver; Metabolism; Mice; Mice, Inbred AKR; Oxidoreductases; Research; Transferases	1964
ACTIVITY OF VITAMIN B12 IN MAMMALIAN CELLS IN TISSUE CULTURE. Annals of the New York Academy of Sciences, 1964, Apr-24, Volume: 112 Topics: Animals; Chick Embryo; Cricetinae; Culture Media; Folic Acid; Haplorhini; Kidney; Leukemia; Leukemia, Lymphoid; Lymphocytes; Mice; Parotid Gland; Pharmacology; Research; Research Design; Skin; Tissue Culture Techniques; Vitamin B 12	1964
THE TREATMENT OF EXPERIMENTAL MOUSE HEMOBLASTOSIS. I. THE EFFECT OF SOME NEW FOLIC ACID ANTIMETABOLITES ON CELL TRANSPLANTED LEUKEMIA IN MICE OF THE AKR STRAIN. Neoplasma, 1964, Volume: 11 Topics: Aminopterin; Animals; Antimetabolites; Antineoplastic Agents; Folic Acid; Leukemia; Leukemia, Experimental; Leukocyte Count; Methotrexate; Mice; Mice, Inbred AKR; Pharmacology; Research; Toxicology	1964
THE SERUM LACTOBACILLUS CASEI FOLATE CLEARANCE TEST IN VARIOUS HEMATOLOGIC DISORDERS. Blood, 1964, Volume: 24 Topics: Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Macrocytic; Blood Chemical Analysis; Folic Acid; Folic Acid Deficiency; Hematologic Diseases; Humans; Lacticaseibacillus casei; Lactobacillus; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Metabolism; Myeloproliferative Disorders; Polycythemia Vera; Primary Myelofibrosis	1964
SIDEROBLASTIC ANAEMIA IN MAN: OBSERVATIONS ON SEVENTY CASES. British journal of haematology, 1965, Volume: 11 Topics: Anemia; Anemia, Hemolytic; Anemia, Hypochromic; Anemia, Sideroblastic; Arthritis; Arthritis, Rheumatoid; Bone Marrow Examination; Diagnosis, Differential; Drug Therapy; Elliptocytosis, Hereditary; Folic Acid; Folic Acid Deficiency; Humans; Leukemia; Malabsorption Syndromes; Pathology; Polycythemia Vera; Spherocytosis, Hereditary; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency	1965
ENZYME STUDIES IN VIRUS-INDUCED NEOPLASMS. I. THE EFFECT OF A MURINE LEUKEMIA ON ENZYMES OF ONE-CARBON METABOLISM AND ON PHOSPHOMONOESTERASES. Cancer research, 1964, Volume: 24 Topics: Alkaline Phosphatase; Animals; Carbon; Esterases; Folic Acid; Histocytochemistry; Leukemia; Leukemia Virus, Murine; Leukemia, Experimental; Ligases; Liver; Metabolism; Mice; Oxidoreductases; Phosphoric Monoester Hydrolases; Research; Spleen; Splenectomy; Thymidine	1964
VALUE OF DETECTION OF FORMIMINOGLUTAMIC ACID IN URINE FOR THE DIAGNOSIS OF MALABSORPTION STATES. British medical journal, 1965, Apr-17, Volume: 1, Issue:5441 Topics: Bile Duct Neoplasms; Carbohydrate Metabolism; Celiac Disease; Crohn Disease; Diagnosis; Electrophoresis; Enteritis; Fatty Acids; FIGLU Test; Fluids and Secretions; Folic Acid; Formiminoglutamic Acid; Histidine; Humans; Leukemia; Leukemia, Lymphoid; Lymphoma; Lymphoma, Non-Hodgkin; Malabsorption Syndromes; Sprue, Tropical; Urine; Vitamin B 12; Xylose	1965
FOLIC ACID ACTIVITY IN LEUKEMIA AND CANCER. Cancer research, 1965, Volume: 25 Topics: Animals; Avian Leukosis Virus; Biological Assay; Blood; Blood Cell Count; Blood Sedimentation; Folic Acid; Geriatrics; Hemoglobins; Hodgkin Disease; Humans; Lactobacillus; Leukemia; Neoplasm Metastasis; Neoplasms; Plasma; Poultry	1965
ON THE SIMILARITY OF DIHYDROFOLATE REDUCTASES FROM AMETHOPTERIN-SENSITIVE AND AMETHOPTERIN-RESISTANT MOUSE LEUKEMIA (L1210) CELLS. Biochemistry, 1964, Volume: 3 Topics: Animals; Benzoates; Enzyme Inhibitors; Folic Acid; Leukemia; Leukemia, Experimental; Methotrexate; Mice; NADP; Oxidoreductases; Pharmacology; Research; Sodium Chloride; Tetrahydrofolate Dehydrogenase	1964
THE EFFECT OF LARGE INTRAVENOUS DOSES OF METHOTREXATE ON URINARY FORMIMINOGLUTAMIC ACID EXCRETION. The Journal of pediatrics, 1965, Volume: 66 Topics: Child; Drug Therapy; FIGLU Test; Folic Acid; Formiminoglutamic Acid; Glutamates; Humans; Injections, Intravenous; Leukemia; Metabolism; Methotrexate; Urine	1965
Folinic acid activity in leucocytes. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1962, Volume: 109 Topics: Folic Acid; Hematologic Tests; Humans; Leucovorin; Leukemia; Leukocytes	1962
Effect of folic acid on in vitro uptake of labeled thymidine by leukemic cells. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1961, Volume: 108 Topics: Biochemical Phenomena; Folic Acid; In Vitro Techniques; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Nucleosides; Nucleotides; Thymidine	1961
Inhibition of growth of amethopterinsensitive and amethopterin-resistant pairs of lymphocytic neoplasms by dietary folic-acid deficiency in mice. Journal of the National Cancer Institute, 1962, Volume: 28 Topics: Animals; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Leukemia; Leukemia, Lymphoid; Lymphocytes; Lymphoma; Methotrexate; Mice; Neoplasms, Experimental	1962
Studies on the role of folic acid in the leukemic process. Cancer, 1950, Volume: 3, Issue:5 Topics: Folic Acid; Folic Acid Antagonists; Humans; Leukemia	1950
Treatment of acute leukemia with amethopterin (4-amino, 10-methyl pteroyl glutamic acid). Acta haematologica, 1950, Volume: 4, Issue:3 Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Glutamates; Leukemia; Methotrexate	1950
The urinary excretion of 17-ketosteroids and corticosteroids in leukemia; the effects of aminopterin (4-amino-pteroylglutamic acid) on the excretion of corticosteroids in acute leukemia. The Journal of laboratory and clinical medicine, 1950, Volume: 36, Issue:6 Topics: 17-Ketosteroids; Adrenal Cortex Hormones; Aminopterin; Androgens; Dermatologic Agents; Folic Acid; Folic Acid Antagonists; Glucocorticoids; Leukemia	1950
A comparison of the effects of 4-amino-N10-methyl-pteroylglutamic acid and 2,6-diaminopurine upon sensitive and resistant sublines of a strain of mouse leukemia. Blood, 1951, Volume: 6, Issue:4 Topics: 2-Aminopurine; Amino Acids; Animals; Folic Acid; Leukemia; Mice	1951
FOLACIN antagonists in the treatment of acute leukemia. Nutrition reviews, 1951, Volume: 9, Issue:5 Topics: Folic Acid; Folic Acid Antagonists; Humans; Leukemia	1951
Response of a resistant variant of leukemic cells to an antagonist of pteroylglutamic acid. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1951, Volume: 77, Issue:2 Topics: Folic Acid; Folic Acid Antagonists; Leukemia; Musculoskeletal Physiological Phenomena	1951
The effect of 4-aminopteroylglutamic acid (aminopterin), a folic acid antagonist on experimentally produced avian leukosis. Veterinary medicine, 1951, Volume: 46, Issue:8 Topics: Aminopterin; Animals; Avian Leukosis; Bird Diseases; Birds; Folic Acid; Folic Acid Antagonists; Leukemia; Meat; Poultry	1951
[Investigation of folic acid antagonist therapy in cancer of hemopoietic organs and leukemia]. Der Krebsarzt, 1951, Aug-01, Volume: 6, Issue:7-8 Topics: Folic Acid; Folic Acid Antagonists; Hematopoietic System; Leukemia; Neoplasms	1951
An unusual case of acute plasma-cell leukemia treated with a folic acid antagonist and urethane. Cancer, 1951, Volume: 4, Issue:5 Topics: Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Plasma Cell; Urethane	1951
The concentration of folic acid in leukocytes; observations on normal subjects and persons with leukemia. Cancer research, 1951, Volume: 11, Issue:11 Topics: Folic Acid; Leukemia; Leukocytes	1951
Citrovorum factor in leucemia; two cases with autopsy findings. The Journal of pediatrics, 1951, Volume: 39, Issue:5 Topics: Autopsy; Folic Acid; Leucovorin; Leukemia	1951
[New data on the therapy and pathogenesis of pernicious anemia and leukemia]. Orvosi hetilap, 1951, Dec-30, Volume: 92, Issue:52 Topics: Anemia; Anemia, Pernicious; Folic Acid; Hematinics; Leukemia; Vitamin B 12	1951
The metabolic displacement of folic acid by aminopterin; studies in leukemia patients. Blood, 1952, Volume: 7, Issue:3 Topics: Aminopterin; Body Fluids; Folic Acid; Folic Acid Antagonists; Leukemia	1952
The nutritional status of folic acid in persons with leukemia and its possible relation to effects of aminopterin therapy. Blood, 1952, Volume: 7, Issue:3 Topics: Aminopterin; Body Fluids; Folic Acid; Humans; Leukemia; Nutritional Status	1952
Treatment of acute leukemia with anti-folic acid compounds (aninopterin and aminoanfol). Cancer, 1952, Volume: 5, Issue:2 Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Leukemia	1952
Aminopterin (4-amino-pteroyl-glutamic acid) therapy in leukemias. Annals of western medicine and surgery, 1949, Volume: 3, Issue:11 Topics: Aminopterin; Folic Acid; Glutamates; Leukemia	1949
The induction of resistance to 4-amino-N10-methylpteroylglutamic acid in a strain of transmitted mouse leukemia. Science (New York, N.Y.), 1950, Volume: 111, Issue:2875 Topics: Amino Acids; Biochemical Phenomena; Folic Acid; Leukemia	1950
The treatment of acute leukemias of childhood with folic acid antagonists. The Journal of pediatrics, 1950, Volume: 36, Issue:1 Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Leukemia	1950
The response of acute leukemia to the administration of the folic acid antagonists, aminopterin and a-methopterin; report of 14 cases. Annals of internal medicine, 1950, Volume: 32, Issue:1 Topics: Acute Disease; Aminopterin; Folic Acid; Folic Acid Antagonists; Leukemia; Pterins	1950
Observations on acute leukemia in children treated with 4-aminopteroylglutamic acid. Pediatrics, 1950, Volume: 5, Issue:1 Topics: Acute Disease; Folic Acid; Leukemia	1950
Chemotherapeutic studies of tumors, including leukemia, in children. American journal of diseases of children (1911), 1950, Volume: 79, Issue:5 Topics: Folic Acid; Humans; Leukemia; Neoplasms	1950
The specificity of 4-aminopteroylglutamic acid (aminopterin) for leukemic hematopoietic tissue. Blood, 1950, Volume: 5, Issue:4 Topics: Aminopterin; Folic Acid; Leukemia; Sensitivity and Specificity	1950
[Acute leukemia and aminopterin]. Boletin medico del Hospital Infantil de Mexico, 1950, Volume: 7, Issue:1 Topics: Acute Disease; Aminopterin; Folic Acid; Leukemia	1950
Platelet regeneration during therapy of acute leukemia with folic acid antagonists. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1950, Volume: 73, Issue:4 Topics: Acute Disease; Blood; Blood Platelets; Folic Acid; Folic Acid Antagonists; Leukemia; Regeneration	1950
Treatment of leukemia and allied disorders with folic acid antagonists, effect of aminopterin on skeletal lesions. Radiology, 1950, Volume: 54, Issue:5 Topics: Aminopterin; Arylsulfonates; Folic Acid; Folic Acid Antagonists; Leukemia	1950
Aminopterin in leukemia. Archives of pediatrics, 1950, Volume: 67, Issue:3 Topics: Aminopterin; Folic Acid; Leukemia	1950
The treatment of acute leukemia with the folic acid antagonist, aminopterin. Virginia medical monthly, 1950, Volume: 77, Issue:6 Topics: Acute Disease; Aminopterin; Blood; Folic Acid; Folic Acid Antagonists; Leukemia	1950
Aminopterin in treatment of leukemia in children; serial aspirations of bone marrow as a guide to management and appraisal of treatment. American journal of diseases of children (1911), 1950, Volume: 79, Issue:6 Topics: Aminopterin; Bone Marrow; Disease Management; Folic Acid; Leukemia	1950
Roentgenographic changes in long bones of leukemic children treated with "aminopterin.". American journal of diseases of children (1911), 1950, Volume: 79, Issue:6 Topics: Aminopterin; Bone and Bones; Folic Acid; Leukemia	1950
Aminopterin in the treatment of acute leukaemia. British medical journal, 1950, Jun-24, Volume: 1, Issue:4668 Topics: Acute Disease; Aminopterin; Folic Acid; Leukemia	1950
[Acute leukemia and folic acid antagonists]. Le Sang, 1950, Volume: 21, Issue:4 Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Leukemia	1950
Acute leukaemia with a folic acid antagonist. Canadian Medical Association journal, 1950, Volume: 63, Issue:3 Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Leukemia	1950
Treatment of leukemia in children with folic acid antagonists. Clinical proceedings - Children's Hospital of the District of Columbia, 1950, Volume: 6, Issue:9 Topics: Folic Acid; Folic Acid Antagonists; Leukemia	1950
Studies on the mechanism of resistance to the 4-amino antagonists of pteroylglutamic acid in leukemia. The Journal of clinical investigation, 1950, Volume: 29, Issue:6 Topics: Folic Acid; Leukemia	1950
[First results of treatment with aminopterin of acute leukemia; preliminary communication]. Minerva pediatrica, 1950, Volume: 2, Issue:6 Topics: Acute Disease; Aminopterin; Communication; Folic Acid; Leukemia	1950
Development of resistance to folic acid antagonists in a transplantable lymphoid leukemia. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1950, Volume: 74, Issue:3 Topics: Biochemical Phenomena; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Lymphoid; Transplants	1950
Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line. Cancer communications, 1991, Volume: 3, Issue:12 Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Breast Neoplasms; Carrier Proteins; Drug Resistance, Neoplasm; Flow Cytometry; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Leucovorin; Leukemia; Methotrexate; Mice; Receptors, Cell Surface; Receptors, Estrogen; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured; Vitamin B Complex	1991
Folate levels and methylation of CDKI proteins. Leukemia research, 2007, Volume: 31, Issue:4 Topics: Cyclin-Dependent Kinase Inhibitor Proteins; DNA Methylation; Folic Acid; Humans; Leukemia	2007
Observations on the treatment of acute leucemias with analogues of folic acid. The Journal of laboratory and clinical medicine, 1948, Volume: 33, Issue:12 Topics: Acute Disease; Folic Acid; Inorganic Chemicals; Leukemia; Organic Chemicals	1948
Treatment of acute leucemia with aminopterin (4-amino-pteroylglutamic acid). The Journal of laboratory and clinical medicine, 1948, Volume: 33, Issue:12 Topics: Acute Disease; Amino Acids; Aminopterin; Folic Acid; Leukemia	1948
Treatment of chronic leucemia with a folic acid antagonist. The Journal of laboratory and clinical medicine, 1948, Volume: 33, Issue:12 Topics: Chronic Disease; Folic Acid; Folic Acid Antagonists; Humans; Leukemia	1948
Some observations on the effect of folic acid antagonists on acute leukemia and other forms of incurable cancer. Blood, 1949, Volume: 4, Issue:2 Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Neoplasms; Vitamin B Complex; Vitamins	1949
The use of folic acid antagonists in the treatment of acute and subacute leukemia. Blood, 1949, Volume: 4, Issue:2 Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Vitamin B Complex; Vitamins	1949
Studies on the chemotherapy of leukemia; the effect of 4-amino-pteroylglutamic acid and 4-amino-N10-methyl-pteroylglutamic acid on transplanted mouse leukemia. Cancer, 1949, Volume: 2, Issue:1 Topics: Folic Acid; Leukemia	1949
Aminopterin, a folic acid antagonist, in the treatment of leukemia. American journal of clinical pathology, 1949, Volume: 19, Issue:2 Topics: Amino Acids; Aminopterin; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Vitamin B Complex; Vitamins	1949
Use of folic acid antagonist in chronic leukemia. American journal of clinical pathology, 1949, Volume: 19, Issue:2 Topics: Chronic Disease; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Vitamin B Complex; Vitamins	1949
Chemotherapy of leukemia; effect of folic acid derivatives on transplanted mouse leukemia. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1949, Volume: 71, Issue:3 Topics: Animals; Folic Acid; Humans; Leukemia; Leukemia, Experimental; Vitamin B Complex; Vitamins	1949
Prevention of chemotherapeutic effects of 4-amino-N10-methyl-pteroylglutamic acid on mouse leukemia by pteroylglutamic acid. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1949, Volume: 71, Issue:4 Topics: Amino Acids; Animals; Biomedical Research; Folic Acid; Leukemia; Leukemia, Experimental	1949
The treatment of acute leukemia with folic acid antagonists. Proceedings of the staff meetings. Mayo Clinic, 1949, Oct-12, Volume: 24, Issue:21 Topics: Acute Disease; Folic Acid; Folic Acid Antagonists; Leukemia	1949
Observations on the effect of a folic-acid antagonist on transplantable lymphoid leukemias in mice. Journal of the National Cancer Institute, 1949, Volume: 10, Issue:1 Topics: Animals; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia, Lymphoid; Mice	1949
Development of macrocytic erythrocytes in leukemic subjects receiving folic acid antagonist, 4-amino-pteroylglutamic acid. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1949, Volume: 71, Issue:1 Topics: Amino Acids; Erythrocytes, Abnormal; Folic Acid; Folic Acid Antagonists; Leukemia; Vitamin B Complex; Vitamins	1949
The reduction of folate and of dihydrofolate by homogenates of leukocytes from patients with leukemia or with myeloid metaplasia. Cancer research, 1967, Volume: 27, Issue:5 Topics: Biological Assay; Clinical Enzyme Tests; Folic Acid; Humans; In Vitro Techniques; Leukemia; Leukocytes; Methotrexate; Oxidation-Reduction; Primary Myelofibrosis; Tetrahydrofolate Dehydrogenase	1967
Similar specificity of membrane transport for folate analogues and their metabolites by murine and human tumor cells: a clinically directed laboratory study. Cancer research, 1984, Volume: 44, Issue:1 Topics: Animals; Biological Transport; Breast Neoplasms; Cell Line; Cell Membrane; Female; Folic Acid; Humans; Kinetics; Leukemia; Leukemia L1210; Neoplasms; Sarcoma 180; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase	1984
Unusual case of acute leukemia. Coexisting acute leukemia and pernicious anemia. The American journal of medicine, 1984, Volume: 76, Issue:6 Topics: Acute Disease; Anemia, Pernicious; Bone Marrow; Cell Division; Cystadenocarcinoma; Female; Folic Acid; Hemoglobins; Humans; Leukemia; Melphalan; Middle Aged; Ovarian Neoplasms; Vitamin B 12; Vitamin B 12 Deficiency	1984
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity. Molecular pharmacology, 1995, Volume: 48, Issue:3 Topics: Acyltransferases; Animals; Biological Transport, Active; Carrier Proteins; Cell Division; Enzyme Inhibitors; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Leucovorin; Leukemia; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Mice; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Receptors, Cell Surface; Reduced Folate Carrier Protein; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase; Tumor Cells, Cultured	1995
[Detection of alterations of dihydrofolate reductase gene in folate-resistant leukemia cells by in vitro enzymatic amplification]. Rinsho byori. The Japanese journal of clinical pathology, 1993, Volume: 41, Issue:7 Topics: Base Sequence; DNA Probes; Drug Resistance; Folic Acid; Humans; Leukemia; Molecular Sequence Data; Nucleic Acid Hybridization; Point Mutation; Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured	1993
Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues. Japanese journal of cancer research : Gann, 1993, Volume: 84, Issue:1 Topics: Antineoplastic Agents; Base Sequence; Blotting, Southern; DNA, Neoplasm; Drug Resistance; Folic Acid; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Leukemia; Methotrexate; Molecular Sequence Data; Oligonucleotide Probes; Polymerase Chain Reaction; Quinazolines; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured	1993
Amplification of the thymidylate synthase gene in an N10-propargyl-5,8-dideazafolic-acid-resistant human leukemia, MOLT-3 cell line developed in pteroylglutamic acid, but not in leucovorin. Journal of cancer research and clinical oncology, 1996, Volume: 122, Issue:11 Topics: Biological Transport; Drug Resistance; Enzyme Inhibitors; Folic Acid; Gene Amplification; Genes; Humans; Leucovorin; Leukemia; Methotrexate; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured	1996
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. The Journal of biological chemistry, 1998, Nov-13, Volume: 273, Issue:46 Topics: Affinity Labels; Biological Transport; Blotting, Northern; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Glutamates; Humans; Kinetics; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Pyrimethamine; Pyrimidines; Reduced Folate Carrier Protein; Structure-Activity Relationship; Tetrahydrofolates; Trimetrexate; Tumor Cells, Cultured	1998
Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells. European journal of biochemistry, 2000, Volume: 267, Issue:3 Topics: 3' Untranslated Regions; Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Division; DNA Primers; DNA, Complementary; DNA, Neoplasm; Folic Acid; Humans; Leukemia; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Reduced Folate Carrier Protein; RNA, Messenger; RNA, Neoplasm; Transfection; Tumor Cells, Cultured	2000
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake. The Journal of biological chemistry, 2000, Oct-06, Volume: 275, Issue:40 Topics: Antimetabolites, Antineoplastic; Biological Transport; Blotting, Northern; Blotting, Southern; Blotting, Western; Carrier Proteins; Cell Division; Cell Membrane; Chlorides; DNA Mutational Analysis; DNA, Complementary; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enzyme Inhibitors; Exons; Folic Acid; Folic Acid Antagonists; Humans; Indoles; Inhibitory Concentration 50; Isoindoles; Kinetics; Leucovorin; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mutagenesis, Site-Directed; Mutation; Polymorphism, Single-Stranded Conformational; Protein Structure, Secondary; Protein Structure, Tertiary; Quinazolines; Recombinant Proteins; Reduced Folate Carrier Protein; Thymidylate Synthase; Time Factors; Transfection; Trimetrexate; Tumor Cells, Cultured	2000
"Should we treat leuchaemia in children?". The Medical journal of Australia, 2001, Aug-06, Volume: 175, Issue:3 Topics: Acute Disease; Child; Disease Progression; Folic Acid; Humans; Leukemia	2001
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis. Biochemical pharmacology, 2002, Jan-15, Volume: 63, Issue:2 Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured	2002
Thymidylate synthetase and 2'-deoxyuridylate form a tight complex in the presence of pteroyltriglutamate. The Journal of biological chemistry, 1979, Dec-25, Volume: 254, Issue:24 Topics: Cell Line; Deoxyuracil Nucleotides; Folic Acid; Humans; Kinetics; Lacticaseibacillus casei; Leukemia; Methyltransferases; Protein Binding; Pteroylpolyglutamic Acids; Thymidylate Synthase	1979
Serum folates in man. Journal of clinical pathology, 1977, Volume: 30, Issue:5 Topics: Anemia, Pernicious; Arthritis, Rheumatoid; Biological Assay; Celiac Disease; Enterococcus faecalis; Folic Acid; Formyltetrahydrofolates; Humans; Lacticaseibacillus casei; Leukemia; Pediococcus; Schizophrenia; Tetrahydrofolates	1977
The isolation of dihydrofolate reductases by affinity chromatography on folate-sepharose. Analytical biochemistry, 1977, May-01, Volume: 79, Issue:1-2 Topics: Animals; Cell Line; Chromatography, Affinity; Folic Acid; Humans; Lacticaseibacillus casei; Leukemia; Leukemia L1210; Leukocytes; Methotrexate; Mice; Sepharose; Tetrahydrofolate Dehydrogenase	1977
Symposium on obstetric hematology. Clinical obstetrics and gynecology, 1979, Volume: 22, Issue:4 Topics: Blood; Blood Platelet Disorders; Disseminated Intravascular Coagulation; Female; Folic Acid; Humans; Iron; Leukemia; Lymphoma; Pregnancy; Pregnancy Complications, Hematologic; Reproduction; Thromboembolism	1979
Specific and non-specific folate binding protein in normal and malignant human tissues. Journal of clinical pathology, 1978, Volume: 31, Issue:7 Topics: Adolescent; Adult; Aged; Carrier Proteins; Female; Folic Acid; Gastrointestinal Neoplasms; Humans; Intestinal Mucosa; Leukemia; Leukocytes; Male; Middle Aged	1978
Folate binding protein in myeloproliferative disorders. Haematologica, 1976, Volume: 61, Issue:3 Topics: Female; Folic Acid; Humans; Leukemia; Pregnancy; Protein Binding	1976
Biopterin derivatives in human body fluids and tissues. Journal of clinical pathology, 1976, Volume: 29, Issue:5 Topics: Adolescent; Adult; Biological Assay; Biopterins; Body Fluids; Brain Chemistry; Chemical Phenomena; Chemistry; Child; Chromatography, DEAE-Cellulose; Culture Media; Eukaryota; Female; Folic Acid; Humans; Leukemia; Liver; Male; Methotrexate; Middle Aged; Milk, Human; Psoriasis; Pteridines	1976
[Acute or subacute myelofibrosis]. Nouvelle revue francaise d'hematologie, 1976, Volume: 16, Issue:1 Topics: Acute Disease; Adult; Aged; Alkaline Phosphatase; Bone Marrow Examination; Cell Survival; Erythrocytes; Erythropoiesis; Female; Folic Acid; Humans; Leukemia; Leukocytes; Male; Middle Aged; Primary Myelofibrosis; Uric Acid; Vitamin B 12	1976
Polyglutamate forms of folate in resting and proliferating mammalian tissues. Clinical science and molecular medicine, 1975, Volume: 48, Issue:1 Topics: Adolescent; Adult; Aged; Animals; Child; Chromatography, DEAE-Cellulose; Female; Folic Acid; Hepatectomy; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Monocytic, Acute; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Liver; Liver Regeneration; Male; Middle Aged; Rats	1975
Folate studies. Folate and vitamin B12 values in relation to bone marrow pattern. Scandinavian journal of haematology. Supplementum, 1975, Volume: 24 Topics: Adolescent; Adult; Age Factors; Aged; Anemia; Bone Marrow; Bone Marrow Cells; Bone Marrow Examination; Child; Child, Preschool; Erythrocytes; Erythropoiesis; Female; Folic Acid; Folic Acid Deficiency; Hemoglobins; Humans; Infant; Leukemia; Male; Megaloblasts; Middle Aged; Sex Factors; Transferrin; Vitamin B 12; Vitamin B 12 Deficiency	1975
Chronic neurologic disturbance in childhood leukemia. Cancer, 1976, Volume: 37, Issue:2 Topics: Adolescent; Antineoplastic Agents; Child; Cyclophosphamide; Cytarabine; Folic Acid; Humans; Learning Disabilities; Leukemia; Leukemia, Lymphoid; Methotrexate; Movement Disorders; Nervous System Diseases; Prospective Studies; Radiotherapy; Seizures; Time Factors	1976
Cancer chemotherapy: What drugs are available. Medical times, 1976, Volume: 104, Issue:2 Topics: Antibiotics, Antineoplastic; Doxorubicin; Folic Acid; History, 19th Century; Hodgkin Disease; Humans; Leukemia; Neoplasms; Nitrogen Mustard Compounds; Vinca Alkaloids	1976
Molecular events in the membrane transport of methotrexate in human CCRF-CEM leukemia cell lines. Advances in enzyme regulation, 1992, Volume: 32 Topics: Affinity Labels; Biological Transport, Active; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Leukemia; Methotrexate; Purines; Receptors, Cell Surface; Thymidine; Tumor Cells, Cultured	1992
The role of folates in the development of methotrexate resistance in human leukemia cell line K562. Journal of cancer research and clinical oncology, 1992, Volume: 119, Issue:2 Topics: Cell Cycle; Drug Resistance; Folic Acid; Humans; Leucovorin; Leukemia; Methotrexate; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured	1992
Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis. Journal of medicinal chemistry, 1992, Mar-06, Volume: 35, Issue:5 Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Binding Sites; Cell Division; Crystallization; Drug Design; Escherichia coli; Folic Acid; Humans; Imidazoles; Leukemia; Leukemia L1210; Mice; Molecular Structure; Quinolines; Thymidylate Synthase; Tumor Cells, Cultured	1992
Multiple membrane transport systems for the uptake of folate-based thymidylate synthase inhibitors. Cancer research, 1990, Dec-01, Volume: 50, Issue:23 Topics: Antineoplastic Agents; Biological Transport; Cell Division; Cells, Cultured; Drug Carriers; Folic Acid; Folic Acid Antagonists; Humans; In Vitro Techniques; Leukemia; Methotrexate; Quinazolines; Thymidylate Synthase	1990
Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase. Journal of medicinal chemistry, 1989, Volume: 32, Issue:6 Topics: Acyltransferases; Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Folic Acid; Humans; Hydroxymethyl and Formyl Transferases; Lacticaseibacillus casei; Leukemia; Leukemia L1210; Mice; Molecular Structure; Phosphoribosylglycinamide Formyltransferase; Purines; Stereoisomerism; Streptococcus; Structure-Activity Relationship; Tumor Cells, Cultured	1989
Cytotoxicity of methotrexate and trimetrexate and its reversal by folinic acid in human leukemic CCRF-CEM cells with carrier-mediated and receptor-mediated folate uptake. Leukemia research, 1989, Volume: 13, Issue:11 Topics: Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Humans; In Vitro Techniques; Leucovorin; Leukemia; Methotrexate; Quinazolines; Receptors, Cell Surface; Trimetrexate; Tumor Cells, Cultured	1989
Interaction of N-hydroxy(sulfo) succinimide active esters with the reduced folate/methotrexate transport system from human leukemic CCRF-CEM cells. Biochimica et biophysica acta, 1989, Nov-03, Volume: 985, Issue:3 Topics: Biological Transport; Cell Membrane; Cross-Linking Reagents; Dithiothreitol; Folic Acid; Humans; Leukemia; Methotrexate; Succinimides; Tumor Cells, Cultured	1989
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. Cancer research, 1986, Volume: 46, Issue:10 Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia; Leukemia L1210; Mice	1986
Effects of folate in culture medium on common fragile sites in lymphocyte chromosomes from normal and leukemic children. Human genetics, 1988, Volume: 81, Issue:1 Topics: Acute Disease; Adolescent; Cells, Cultured; Child; Child, Preschool; Chromosome Fragile Sites; Chromosome Fragility; Culture Media; Female; Folic Acid; Humans; Infant; Leukemia; Lymphocytes; Male	1988
Effect of cobalamin inactivation on folate metabolism of leukemic cells. Leukemia research, 1988, Volume: 12, Issue:11-12 Topics: Bone Marrow; Cell Line; Deoxyuridine; Female; Folic Acid; Humans; Leukemia; Male; Methotrexate; Nitrous Oxide; Tumor Cells, Cultured; Vitamin B 12	1988
[Congenital megaloblastic anemia caused by a deficit of transcobalamin II. Effect of the prolonged administration of folic acid at high dosage]. Sangre, 1987, Volume: 32, Issue:6 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Diagnosis, Differential; Female; Folic Acid; Humans; Infant; Leukemia; Leukemoid Reaction; Transcobalamins	1987
Uracil-uric refractory anemia with peroxidase negative neutrophils. The Tohoku journal of experimental medicine, 1965, Oct-25, Volume: 87, Issue:1 Topics: Anemia, Hypochromic; Anemia, Macrocytic; Blood Cell Count; Bone Marrow; Child; Chromatography; Chromosomes; Female; Folic Acid; Humans; Leukemia; Neutrophils; Peroxidases; Porphyrins; Staining and Labeling; Succinate Dehydrogenase; Uracil; Uracil Nucleotides; Urine; Vitamin B 12	1965
Excretion of formiminoglutamic acid in reticulosis and carcinoma. Lancet (London, England), 1966, Feb-26, Volume: 1, Issue:7435 Topics: Anemia, Macrocytic; Blood Chemical Analysis; FIGLU Test; Folic Acid; Humans; Leukemia; Lymphatic Diseases; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neoplasms; Urine; Vitamin B 12	1966
[Activity of methionine synthetase (5-methyl-5,6,7,8-tetrahydrofolate: homocysteine methyltransferase) as a proliferation parameter in growing cells]. Acta haematologica, 1973, Volume: 49, Issue:4 Topics: Cell Division; Cells, Cultured; Cytarabine; DNA Nucleotidyltransferases; Folic Acid; Humans; In Vitro Techniques; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Methionine; Methyltransferases; Prednisolone; Tetrahydrofolates; Thioguanine; Thymidine Kinase; Vincristine	1973
Folates in human serum. Journal of clinical pathology, 1974, Volume: 27, Issue:11 Topics: Administration, Oral; Biological Assay; Celiac Disease; Chromatography, Thin Layer; Enterococcus faecalis; Folic Acid; Humans; Lactobacillus; Leukemia; Pseudomonas; Time Factors	1974
Dyserythropoiesis, refractory anemia, and "preleukemia:" metabolic features of the erythrocytes. Blood, 1973, Volume: 41, Issue:6 Topics: Adolescent; Adult; Aged; Anemia, Hemolytic; Anemia, Hemolytic, Autoimmune; Child; Child, Preschool; Erythrocyte Count; Erythrocytes; Erythropoiesis; Female; Folic Acid; Glutathione; Hematocrit; Hematologic Diseases; Humans; Leukemia; Male; Middle Aged; Phosphofructokinase-1; Precancerous Conditions	1973
[Biochemistry of normal and leukemic white blood cells]. Zeitschrift fur klinische Chemie und klinische Biochemie, 1967, Volume: 5, Issue:5 Topics: Bone Marrow; Bone Marrow Cells; DNA, Neoplasm; Folic Acid; Glycolysis; Humans; Isomerases; Leukemia; Leukocytes; Ligases; Methotrexate; Nucleotides; Oxidoreductases; Phosphoric Monoester Hydrolases; Phosphotransferases; Tetrahydrofolate Dehydrogenase; Thymidine Kinase; Transaminases	1967
Serum folate levels in malignant disorders. The Journal of the Association of Physicians of India, 1974, Volume: 22, Issue:5 Topics: Adolescent; Adult; Anemia; Child; Female; Folic Acid; Hemoglobins; Humans; Leukemia; Male; Middle Aged; Neoplasms	1974
Proceedings: Pharmacokinetics of folates in the rat and man. Clinical science and molecular medicine, 1974, Volume: 47, Issue:5 Topics: Animals; Arthritis, Rheumatoid; Brain Chemistry; Celiac Disease; Crohn Disease; Folic Acid; Humans; Intestines; Kidney; Kinetics; Leukemia; Liver; Rats; Tetrahydrofolates	1974
Encephalopathy in acute leukaemia associated with methotrexate therapy. Archives of disease in childhood, 1972, Volume: 47, Issue:253 Topics: Acute Disease; Adult; Ataxia; Brain Diseases; Child; Child, Preschool; Cognition Disorders; Electroencephalography; Epilepsy; Female; Folic Acid; Humans; Injections, Spinal; Leukemia; Leukemia, Lymphoid; Male; Meninges; Methotrexate; Psychoses, Substance-Induced; Tremor	1972
Megaloblastosis in hematologic malignancy. Southern medical journal, 1973, Volume: 66, Issue:9 Topics: Adult; Aged; Erythrocytes; Folic Acid; Histiocytes; Hodgkin Disease; Humans; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Lymphoma, Large B-Cell, Diffuse; Middle Aged; Vitamin B 12	1973
The biochemist's outlook on cancer research. Federation proceedings, 1973, Volume: 32, Issue:12 Topics: Aerobiosis; Animals; Antineoplastic Agents; Biochemistry; Carbon Radioisotopes; Cell Transformation, Neoplastic; DNA Replication; England; Folic Acid; Folic Acid Antagonists; Glycolysis; History, 20th Century; Humans; Isotope Labeling; Lactates; Leukemia; Mice; Neoplasms; Research; Tetrahydrofolates; Thymidine; Thymidylate Synthase; Thymine; United States	1973
Studies on serum folate activity in leukaemia and allied disorders. Bulletin of the Calcutta School of Tropical Medicine, 1972, Volume: 20, Issue:3 Topics: Folic Acid; Humans; Leukemia	1972
Rapid separation of methotrexate from folate reductase. Analytical biochemistry, 1973, Volume: 53, Issue:2 Topics: Folic Acid; Hematopoietic System; Ion Exchange Resins; Leukemia; Methotrexate; Tetrahydrofolate Dehydrogenase; Time Factors	1973
[B12, folic acid and megaloblastic anemias]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1974, Feb-20, Volume: 94, Issue:5 Topics: Anemia, Hemolytic; Anemia, Macrocytic; Anemia, Pernicious; Erythrocytes, Abnormal; Folic Acid; Folic Acid Deficiency; Humans; Leukemia; Liver Cirrhosis; Vitamin B 12; Vitamin B 12 Deficiency	1974
Serum folate and serum vitamin B12 in patients with malignant hematologie diseases. Cancer research, 1965, Volume: 25, Issue:11 Topics: Blood; Folic Acid; Hodgkin Disease; Humans; In Vitro Techniques; Leukemia; Leukemia, Myeloid; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Vitamin B 12	1965
[Formate activation and de novo synthesis of purine nucleotides in leukemia cells and its therapeutic modification by 6-mercaptopurine]. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimentelle Chirurgie, 1968, Volume: 147, Issue:2 Topics: Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Chromatography, Paper; Folic Acid; Formates; Humans; Leukemia; Leukocytes; Ligases; Mercaptopurine; Nucleosides; Nucleotides; Oxidoreductases; Purines; Tetrahydrofolate Dehydrogenase	1968
A possible unifying principle in the chemotherapy of certain protozoal diseases and of leukemia. The Medical annals of the District of Columbia, 1969, Volume: 38, Issue:2 Topics: Amebiasis; Arsenicals; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Trypanosomiasis, African	1969
Treatment of leukemia with large doses of methotrexate and folinic acid: clinical-biochemical correlates. The Journal of clinical investigation, 1969, Volume: 48, Issue:11 Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Deoxyuridine; DNA, Neoplasm; Female; Folic Acid; Humans; Leukemia; Leukemia, Lymphoid; Male; Methotrexate; Middle Aged; Tetrahydrofolate Dehydrogenase; Thymidine; Tritium	1969
Leukaemia and pregnancy. A report of five cases and discussion of management. The Journal of obstetrics and gynaecology of the British Commonwealth, 1968, Volume: 75, Issue:5 Topics: Adult; Antineoplastic Agents; Female; Folic Acid; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Pregnancy; Pregnancy Complications, Hematologic; Prenatal Care; Puerperal Disorders	1968
Sideroblastic anaemia and its association with leukaemia and myelomatosis: a report of five cases. British journal of haematology, 1971, Volume: 20, Issue:4 Topics: Aged; Anemia, Hypochromic; Anemia, Sideroblastic; Blood Platelets; Bone Marrow Cells; Erythrocyte Count; Female; Folic Acid; Hemoglobinometry; Humans; Iron; Leukemia; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocyte Count; Male; Middle Aged; Multiple Myeloma; Reticulocytes; Vitamin B 12	1971
Leukocyte folate activity in patients with leukemia. New York state journal of medicine, 1971, Volume: 71, Issue:19 Topics: Adult; Aged; Child; Female; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Leukemia, Lymphoid; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukocytes; Male; Middle Aged; Pregnancy	1971
Microchromosomes in human preleukemia and leukemia. Cancer, 1971, Volume: 27, Issue:1 Topics: Adult; Aged; Blood Cell Count; Bone Marrow Cells; Cell Division; Chromosome Aberrations; Chromosomes, Human, 1-3; Chromosomes, Human, 13-15; Chromosomes, Human, 16-18; Chromosomes, Human, 19-20; Chromosomes, Human, 21-22 and Y; Chromosomes, Human, 4-5; Chromosomes, Human, 6-12 and X; Clone Cells; Female; Folic Acid; Humans; Karyotyping; Leukemia; Leukocytes; Male; Middle Aged; Vitamin B 12	1971
[FIGLU (formimino-glutamic acid): urinary excretion in malignant neoplasms in childhood]. Minerva pediatrica, 1967, Dec-22, Volume: 19, Issue:51 Topics: Adolescent; Anemia; Antineoplastic Agents; Child; Child, Preschool; Female; FIGLU Test; Folic Acid; Humans; Infant; Leukemia; Liver Diseases; Male; Neoplasms; Nutrition Disorders	1967
The clinical and experimental studies on the metabolism of folic acid using tritiated folic acid. I. Absorption tests of tritiated folic acid in man. The Journal of vitaminology, 1968, Mar-10, Volume: 14, Issue:1 Topics: Anemia; Chromatography; Cobalt Isotopes; Feces; Folic Acid; Gastrointestinal Diseases; Hematologic Diseases; Humans; Intestinal Diseases; Leukemia; Myelitis; Radiometry; Stomach Diseases; Tritium; Vitamin B 12	1968
The clinical and experimental studies on the metabolism of folic acid using tritiated folic acid. 3. Plasma clearance in man and organ distribution in rat following intravenous administration of tritiated folic acid. The Journal of vitaminology, 1968, Mar-10, Volume: 14, Issue:1 Topics: Acute Disease; Animals; Body Weight; Bone Marrow; Carbon Tetrachloride; Chronic Disease; Folic Acid; Hematologic Diseases; Humans; Injections, Intravenous; Kidney; Leukemia; Liver; Liver Diseases; Methotrexate; Rats; Spleen; Tritium	1968
[On the determination of folic acid activity of human blood in controls and in different pathological states]. Internationale Zeitschrift fur Vitaminforschung. International journal of vitamin research. Journal international de vitaminologie, 1969, Volume: 39, Issue:1 Topics: Adolescent; Adult; Anemia, Hypochromic; Anemia, Pernicious; Bone Marrow Diseases; Diabetes Mellitus; Erythrocytes; Female; Folic Acid; Hematologic Diseases; Humans; Leukemia; Liver Cirrhosis; Lymphatic Diseases; Male; Methods; Middle Aged; Neoplasms; Polycythemia Vera; Vitamin B 12 Deficiency	1969
[Low folic acid diet in malignant tumors]. Deutsche medizinische Wochenschrift (1946), 1969, Jun-20, Volume: 94, Issue:25 Topics: Choriocarcinoma; Diet Therapy; Female; Folic Acid; Humans; Leukemia; Neoplasm Metastasis; Neoplasms; Pregnancy	1969
[Does folic acid encourage tumor growth?]. Munchener medizinische Wochenschrift (1950), 1969, Jan-03, Volume: 111, Issue:1 Topics: Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Neoplasms	1969
[Folic acid dependent enzymes and nucleotide synthesis in normal and leukemic leukocytes]. Acta vitaminologica, 1965, Volume: 19, Issue:5 Topics: Antineoplastic Agents; Enzymes; Folic Acid; Hexokinase; Humans; Leukemia; Leukocytes; Ligases; Multiple Myeloma; Nucleotides; Oxidoreductases; Tetrahydrofolate Dehydrogenase	1965