folic acid has been researched along with Leukemia L 1210 in 204 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 136 (66.67) | 18.7374 |
| 1990's | 57 (27.94) | 18.2507 |
| 2000's | 9 (4.41) | 29.6817 |
| 2010's | 2 (0.98) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harvison, PJ; Kalman, TI | 1 |
| Forsch, RA; Moran, RG; Rosowsky, A | 2 |
| Beardsley, GP; Grindey, GB; Hamby, JM; Moran, RG; Rinzel, SM; Shih, C; Taylor, EC | 1 |
| Gaumont, Y; Ghazala, M; Kalman, TI; Kisliuk, RL; Nair, MG; Toghiyani, TR | 1 |
| Beardsley, GP; Fletcher, SR; Harrington, PJ; Moran, RG; Taylor, EC | 1 |
| Lee, RJ; Li, H; Wu, J; Xiong, S; Yu, B | 2 |
| Goldman, ID; Wang, Y; Zhao, R | 1 |
| Gao, F; Goldman, ID; Wang, Y; Zhao, R | 1 |
| BIEDLER, JL; GREENBERG, NH; HUTCHISON, DJ; ROBINSON, DL; SCHRECKER, AW; VENDITTI, JM | 1 |
| ADAMSON, RH; MISRA, DK | 1 |
| MISRA, DK | 1 |
| ANDERSON, EP; BROCKMAN, RW | 1 |
| HUENNEKENS, FM; SCHRECKER, AW | 1 |
| BRINDLE, SD; HIRSCHBERG, E; SEMENTE, G | 1 |
| GREENBERG, NH; MEAD, JA; SCHRECKER, AW; SEEGER, DR; TOMCUFCIK, AS | 1 |
| Leamon, CP; Low, PS; Paulos, CM; Reddy, JA; Turk, MJ | 1 |
| Bavetsias, V; Forster, MD; Gibbs, DD; Green, M; Henderson, E; Jackman, AL; Mitchell, F; Raynaud, F; Theti, DS; Valenti, M; Wood, N | 1 |
| Bertino, JR; Fernandes, DJ | 1 |
| Bertino, JR; Fernandes, DJ; Moroson, BA | 1 |
| Besserer, JA; Boritzki, TJ; Elslager, EF; Fry, DW; Jackson, RC; Leopold, WR; Sloan, BJ | 1 |
| Fujii, K; Huennekens, FM; Nagasaki, T; Vitols, KS | 1 |
| Dembo, M; Sirotnak, FM; Yang, CH | 3 |
| Calvert, AH; Harrap, KR; Jackman, AL; Taylor, GA | 2 |
| Besserer, JA; Boritzki, TJ; Fry, DW | 1 |
| Ahmed, T; DeGraw, JI; Moccio, DM; Piper, JR; Samuels, LL; Sirotnak, FM; Yagoda, A | 1 |
| Calvert, AH; Harrap, KR; Hart, LI; Jackman, AL | 1 |
| Belousova, AK; Gerasimova, GK; Greshilov, MM; Vorontsov, IN | 2 |
| Chen, SY; Gaumont, Y; Kisliuk, RL; Nair, MG; Strumpf, D | 1 |
| Bertino, JR; Cashmore, AR; Dreyer, RN; Moroson, BA; Scanlon, KJ | 1 |
| Fujii, K; Huennekens, FM; Nagasaki, T | 2 |
| Benkovic, SJ | 1 |
| Bertino, JR; Kamen, BA | 1 |
| Banerjee, CK; Bennett, LL; Brockman, RW; Sani, BP; Temple, C | 1 |
| Gaumont, Y; Kisliuk, RL; McCaleb, GS; Montgomery, JA; Piper, JR; Sirotnak, FM | 2 |
| Henderson, GB; Huennekens, FM; Suresh, MR; Vitols, KS | 2 |
| Brown, SJ; Calvert, AH; Harrap, KR; Jackman, AL; Jones, M; Jones, TR | 1 |
| Calvert, AH; Dady, PJ; Grzelakowska-Sztabert, B; Harrap, KR; Jones, TR; Paine, RM; Taylor, GA | 1 |
| Boyle, FT; Brown, M; Brunton, L; Jackman, AL; Kimbell, R | 1 |
| Aherne, GW; Boyle, FT; Brown, M; Gibson, W; Hardcastle, A; Jackman, AL; Kelland, LR; Kimbell, R | 1 |
| Boyle, FT; Forsch, RA; Hynes, JB; Jackman, AL; Kathmann, I; Peters, GJ; Pinedo, HM; Rosowsky, A; Schornagel, JH; Westerhof, GR | 1 |
| Brigle, KE; Kranz, DM; Patrick, TA; Roy, EJ; Spinella, MJ | 1 |
| Andis, SL; Gates, SB; Grindey, GB; Mendelsohn, LG; Ratnam, M; Schultz, RM; Shackelford, KA; Shih, C | 1 |
| Christopherson, RI; Schoettle, SL | 1 |
| Barker, AJ; Boyle, FT; Calvert, AH; Hughes, LR; Jackman, AL; Kimbell, R; Marsham, PR; O'Connor, BM; Pegg, SJ; Wardleworth, JM | 1 |
| Chong, LK; Tattersall, MH | 1 |
| Brigle, KE; Goldman, ID; Sierra, EE; Spinella, MJ | 1 |
| Schlemmer, SR; Sirotnak, FM | 1 |
| Bunni, MA; Otter, GM; Priest, DG; Sirotnak, FM | 1 |
| Bavetsias, V; Bisset, GM; Calvert, AH; Hughes, LR; Jackman, AL; Pawelczak, K; Thornton, TJ | 1 |
| Bisset, GM; Boyle, FT; Gibson, W; Jackman, AL; Jodrell, DI; Judson, IR | 1 |
| Bavetsias, V; Bisset, GM; Calvert, AH; Gibson, W; Harrap, KR; Jackman, AL; Jodrell, DI; Kimbell, R; Smith, MN; Stephens, TC | 1 |
| Boyle, FT; Brown, M; Hughes, LR; Jackman, AL; Kimbell, R; Matusiak, ZS; Slater, AM; Smith, MN; Stephens, TC | 1 |
| Bavetsias, V; Bisset, GM; Boyle, FT; Jackman, AL; Pawelczak, K; Thornton, TJ | 1 |
| Aherne, W; Boyle, FT; Hardcastle, A; Jackman, AL; Kimbell, R | 1 |
| Bavetsias, V; Bisset, GM; Boyle, FT; Gibson, W; Jackman, AL; Kimbell, R | 1 |
| Cowan, KH; Dyer, DL; Nguyen, TT; Rubin, SA; Said, HM | 1 |
| Kalman, TI; Mao, Z; Pan, J | 1 |
| Fan, J; Huennekens, FM; Kureshy, N; Vitols, KS | 1 |
| Bavetsias, V; Bisset, GM; Boyle, FT; Gibson, W; Jackman, AL; Kimbell, R; Marriott, JH | 1 |
| Fan, J; Huennekens, FM | 1 |
| Brigle, KE; Goldman, ID; Seither, R; Sharina, IG; Wang, PJ; Zhao, R | 1 |
| Assaraf, YG; Goldman, ID; Zhao, R | 1 |
| Brigle, K; Moran, RG; Taylor, SM; Tse, A | 1 |
| Moran, RG; Tse, A | 1 |
| Goldman, ID; Sierra, EE | 1 |
| Brunton, LA; Jackman, AL; Kimbell, R; Ormerod, MG; Skelton, LA; Titley, J | 1 |
| Bowman, KJ; Calvert, AH; Curtin, NJ; Golding, BT; Griffin, RJ; Huang, B; Loughlin, PJ; Newell, DR; Turner, RN | 1 |
| Gao, F; Goldman, ID; Wang, PJ; Zhao, R | 1 |
| Assaraf, YG; Drori, S; Goldman, ID; Jansen, G; Shemer, G; Sprecher, H | 1 |
| Chiao, JH; Kühnel, JM; Sirotnak, FM | 1 |
| Babani, S; Gao, F; Goldman, ID; Liu, L; Zhao, R | 1 |
| Gao, F; Goldman, ID; Zhao, R | 1 |
| Henderson, GB; Huennekens, FM; Suresh, MR | 1 |
| Chaykovsky, M; Gaumont, Y; Kisliuk, RL; Martinelli, JE | 1 |
| Bertino, JR; Hynes, JB; Moroson, BA; Scanlon, KJ | 1 |
| Lee, M; Martin, DW; Santi, DV; Ullman, B | 1 |
| Henderson, GB; Russell, A; Singh, P; Whiteley, JM; Zevely, EM | 1 |
| DeGraw, JI; Dorick, DM; Moccio, DM; Sirotnak, FM | 1 |
| Chello, PL; Peterson, RH; Sirotnak, FM; Yang, CH | 1 |
| Harrap, KR | 1 |
| Crawford, EJ; Friedkin, M; Plante, LT | 2 |
| Arons, E; Costa, MD; Fischer, C; Iqbal, MP; Rothenberg, SP | 1 |
| Colvin, PL; Eason, DE; Garrett, CM; Hynes, JB | 1 |
| Hynes, JB; Oatis, JE | 1 |
| Moran, RG; Werkheiser, WC; Zakrzewski, SF | 1 |
| Bertino, JR; Cashmore, A; Chello, P; Coward, JK; Horvath, CG; Panichajakul, S; Stout, RW | 1 |
| Harrap, KR; Jackson, RC; Taylor, GA | 1 |
| Bruckner, HW; Schreiber, C; Waxman, S | 1 |
| Garrett, CM; Hynes, JB | 1 |
| Fan, J; Huennekens, FM; Pope, LE; Vitols, KS | 2 |
| Bader, H; Beardsley, GP; DeYarman, MT; Freisheim, JH; Galivan, J; Kerwar, SS; Moroson, BA; O'Connor, BM; Rosowsky, A; Russello, O | 1 |
| Fan, J; Huennekens, FM; Vitols, KS | 2 |
| Goldman, ID; Rape, TJ; Seither, RL | 2 |
| Barker, AJ; Bishop, JA; Burrows, KD; Hughes, LR; Jackman, AL; O'Connor, BM; Roberts, N; Warner, P | 1 |
| Fuhry, MA; Janson, CA; Jordan, SR; Matthews, DA; Nguyen, D; Pino, MJ; Reich, SH; Smith, WW; Webber, S; Welsh, KM | 1 |
| Kwok, JB; Tattersall, MH | 2 |
| Jackman, AL; Jansen, G; Kathmann, I; Rijksen, G; Schornagel, JH; van Emmerik, N; Westerhof, GR | 1 |
| Galivan, J; Malik, ND; Piper, JR; Rhee, MS; Sirotnak, FM | 1 |
| Goldman, ID; Seither, RL; Trent, DF | 2 |
| Brown, M; Calvert, AH; Gibson, W; Hughes, LR; Jackman, AL; Judson, IR; Kimbell, R; Taylor, GA | 1 |
| Calvert, AH; Flinn, A; Jackman, AL; Jones, TR; O'Connor, BM; Thornton, TJ; Warner, P | 1 |
| Czajkowski, CA; Matherly, LH; Muench, SP; Psiakis, JT | 1 |
| Keyomarsi, K; Moran, RG | 2 |
| Bishop, JA; Burrows, KD; Calvert, AH; Hughes, LR; Jackman, AL; Jones, TR; Marsham, PR; O'Connor, BM; Oldfield, J; Smith, RC | 1 |
| Bishop, JA; Calvert, AH; Hughes, LR; Jackman, AL; Jones, TR; Marsham, PR; O'Connor, BM; Thornton, TJ | 1 |
| Henderson, GB; Tsuji, JM | 1 |
| Henderson, GB; Strauss, BP | 2 |
| Bishop, JA; Calvert, AH; Jackman, AL; Moran, RG; O'Connor, BM; Taylor, GA | 1 |
| Arbuck, SG; Creaven, PJ; Herrera, L; Mittelman, A; Petrelli, N; Rustum, YM; Trave, F; Zakrzewski, SF | 1 |
| Calvert, AH; Jackman, AL; Jones, TR; Newell, DR; Sikora, E; Simmonds, AJ | 1 |
| Calvert, AH; Jackman, AL; Newell, DR; Sikora, E | 1 |
| Balińska, M | 1 |
| Iseki, T; Iwasa, S; Kanazawa, S; Kondo, H; Ohto, M; Okuda, K | 1 |
| Duch, DS; Edelstein, MP; Ferone, R; Gaumont, Y; Kisliuk, RL; Murthy, BR; Nair, MG; Patil, SD; Thorndike, J | 1 |
| Chang, CM; Fan, J; Huennekens, FM; Minskoff, SA; Pope, LE; Vitols, KS | 1 |
| Gaumont, Y; Kisliuk, RL; Murthy, BR; Nair, MG; Piper, JR; Sirotnak, FM; Thorndike, J | 1 |
| Bertino, JR; Chou, TC; Romanini, A; Sherwood, RF; Sobrero, AF | 1 |
| Goldman, ID; Mikulecky, DC; Rape, TJ; Seither, RL; Trent, DF | 1 |
| Henderson, GB | 1 |
| Balmanno, K; Calvert, AH; Hughes, LR; Jackman, AL; Taylor, GA | 1 |
| Braakhuis, BJ; Jansen, G; Kathmann, I; Rademaker, BC; Rijksen, G; Schornagel, JH; Westerhof, GR | 1 |
| Calvert, AH; Flinn, A; Jackman, AL; Jones, TR; Newell, DR; Thornton, TJ | 1 |
| Cole, A; Freisheim, JH; Hagan, RL; Hynes, JB; Kohler, W; Patil, SA | 1 |
| Bunni, M; Priest, DG; Sirotnak, FM | 1 |
| FitzGerald, GB; Wick, MM | 1 |
| Mines, LS; Sirotnak, FM; Yang, CH | 1 |
| Alison, DL; Calvert, AH; Harrap, KR; Jackman, AL | 1 |
| Barlowe, CK; Goldman, ID; Matherly, LH; Phillips, VM | 1 |
| Henderson, GB; Huennekens, FM | 1 |
| Delcamp, TJ; Freisheim, JH; Kumar, AA; Price, EM; Smith, PL; Susten, SS | 1 |
| Gaumont, Y; Hsiao, MC; Kalman, TI; Kisliuk, RL; Nair, IG; Nair, MG; Nanavati, NT | 1 |
| Chang, CM; Huennekens, FM; Minskoff, SA; Pope, LE; Vitols, KS | 1 |
| Brown, VH; Colwell, WT; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Sato, M; Sirotnak, FM; Thorndike, J | 1 |
| Bunni, M; Doig, MT; Donato, H; Kesavan, V; Priest, DG | 1 |
| Henderson, GB; Kumar, HP; Tsuji, JM | 1 |
| Karasawa, M; Maekawa, T; Omine, M; Yatabe, H | 1 |
| Barrueco, JR; Poser, RE; Sirotnak, FM | 1 |
| Crossley, PH; Imam, AM; Jackman, AL; Little, PF | 1 |
| Barrueco, JR; Gaumont, Y; Goutas, LJ; Jacobsen, DM; Kisliuk, RL; Mines, LS; Sirotnak, FM | 1 |
| Burchenal, JH; Fox, JJ; Huang, JT; Su, TL; Watanabe, KA | 1 |
| Boritzki, TJ; Fry, DW; Hook, KE; Jackson, RC; Leopold, WR; Roberts, BJ | 1 |
| Goutas, LJ; Mines, LS; Sirotnak, FM | 1 |
| Goldin, A | 1 |
| Sirotnak, FM | 1 |
| Cheng, YC; Dutschman, GE; Fisher, MH; Nair, MG; Nanavathi, NT; Starnes, MC | 1 |
| Doig, MT; Kesavan, V; Priest, DG; Scanlon, KJ; Sur, P | 1 |
| Moccio, DM; Samuels, LL; Sirotnak, FM | 1 |
| DiGirolamo, PM; Fujii, K; Henderson, GB; Huennekens, FM; Jacobsen, DW; Neef, VG; Rader, JI | 1 |
| Roberts, EC; Shealy, YF | 3 |
| Elliott, RD; Montgomery, JA; Temple, C | 1 |
| Harrap, KR; Jackson, RC | 1 |
| Bertino, JR; Perkins, JP | 1 |
| Bertino, JR; Hillcoat, BL; Perkins, JP | 1 |
| Bertino, JR; Cashmore, AR; Hillcoat, BL | 1 |
| Gauldie, J; Hillcoat, BL | 1 |
| Bertino, JR; McCullough, JL | 1 |
| Huennekens, FM; Niethammer, D; Rader, JI | 1 |
| Clark, BR; Halpern, BC; Halpern, RM; Hardy, DN; Smith, RA | 1 |
| Bertino, JR; Cashmore, AR; Coward, JK; Parameswaran, KN | 1 |
| Harrap, KR; Jackson, RC; Jackson, ST; Tattersall, MH | 1 |
| Drais, JH; Huennekens, FM; Jackson, RC; Mell, GP; Whiteley, JM | 1 |
| Hillcoat, BL; Kawai, M | 1 |
| Donsbach, RC; Sirotnak, FM | 1 |
| Crawford, EJ; Friedkin, M; Livingston, D | 1 |
| Crawford, EJ; Friedkin, M; Goldin, A; Kisliuk, RL; Kwok, G; Mead, JA; Plante, L | 1 |
| Mead, JA; Mishra, LC | 2 |
| Bertino, JR; Nahas, A; Nixon, PF | 1 |
| Bobzien, WF; Goldman, ID | 1 |
| Friedkin, M; Nahas, A | 1 |
| Bertino, JR; Chabner, BA; Chello, PL | 1 |
| Calman, N; Eng, B; Slater, LM; Wallerstein, H | 1 |
| Goldman, ID | 2 |
| Mead, JA; Mishra, LC; Parmar, AS | 2 |
| Furness, ME; Harrap, KR; Hart, LI; Hill, BT | 1 |
| Goldman, ID; Lichtenstein, NS; Oliverio, VT | 2 |
| Bertino, JR; McCullough, JL; O'Brien, P | 1 |
| Bertino, JR; Nixon, PF | 1 |
| Goldman, ID; Lichtenstein, NS | 1 |
| Albrecht, AM; Biedler, JL; Hoshino, A; Hutchison, DJ | 1 |
| Bjerregaard, MR; Hutchison, DJ; Ittensohn, OL | 1 |
| Roberts, D | 1 |
8 review(s) available for folic acid and Leukemia L 1210
| Article | Year |
|---|---|
BIOCHEMISTRY OF CANCER (METABOLIC ASPECTS).
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Azaguanine; Azaserine; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Floxuridine; Fluorouracil; Folic Acid; Glutamine; Leukemia L1210; Mercaptopurine; Methotrexate; Mitomycin; Neoplasms; Neoplasms, Experimental; Pharmacology; Purines; Puromycin; Pyrimidines; Research; RNA; RNA, Neoplasm; Thioguanine; Thiouracil | 1963 |
On the mechanism of action of folate- and biopterin-requiring enzymes.
Topics: Animals; Bacteria; Biopterins; Folic Acid; Formaldehyde; Formates; Glycine Hydroxymethyltransferase; Leukemia L1210; Liver; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Mixed Function Oxygenases; Molecular Conformation; Oxidation-Reduction; Pteridines; Tetrahydrofolate Dehydrogenase | 1980 |
Folate and anti-folate transport in mammalian cells.
Topics: Animals; Biological Transport; Cell Line; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Leukemia L5178; Liver Neoplasms, Experimental; Methotrexate; Neoplasms, Experimental | 1980 |
Anti-folate toxicity and its reversal.
Topics: Animals; Bone Marrow; Cell Line; DNA Replication; Folic Acid; Folic Acid Antagonists; Glycine Hydroxymethyltransferase; Intestinal Mucosa; Intestines; Kinetics; Leukemia L1210; Methotrexate; Mice | 1976 |
Membrane transport of folate compounds.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Division; Cell Membrane; Folic Acid; Humans; Leukemia L1210; Tumor Cells, Cultured | 1992 |
Visualization of folate transport proteins by covalent labeling with fluorescein methotrexate.
Topics: Animals; Carrier Proteins; Fluorescent Dyes; Folate Receptors, GPI-Anchored; Folic Acid; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface | 1990 |
Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer.
Topics: Animals; Biological Transport; Cell Division; Cell Transformation, Neoplastic; Extraembryonic Membranes; Female; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Neoplasms; Oncogenes; Pregnancy | 1985 |
Folic acid and vitamin B12: transport and conversion to coenzyme forms.
Topics: Animals; Biological Transport, Active; Cell Line; Cell Membrane; Coenzymes; Folic Acid; Kinetics; Lacticaseibacillus casei; Leukemia L1210; Methotrexate; Models, Biological; Mutation; NADP; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Vitamin B 12 | 1974 |
196 other study(ies) available for folic acid and Leukemia L 1210
| Article | Year |
|---|---|
Synthesis and biological activity of novel folic acid analogues: pteroyl-S-alkylhomocysteine sulfoximines.
Topics: Animals; Antineoplastic Agents; Cell Division; Folic Acid; Homocysteine; Leukemia L1210; Methionine Sulfoximine; Mice; Molecular Structure; Pterins; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1992 |
Folic acid analogues lacking the 2-carbon are substrates for folylpolyglutamate synthetase and inhibit cell growth.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Indicators and Reagents; Kinetics; Leukemia L1210; Mice; Molecular Structure; Peptide Synthases; Structure-Activity Relationship; Substrate Specificity | 1991 |
Synthesis and antitumor activity of 5-deaza-5,6,7,8-tetrahydrofolic acid and its N10-substituted analogues.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Humans; Leukemia L1210; Mice; Nitrogen; Purines; Tetrahydrofolates; Tumor Cells, Cultured | 1989 |
Folate analogues. 25. Synthesis and biological evaluation of N10-propargylfolic acid and its reduced derivatives.
Topics: Animals; Folic Acid; Indicators and Reagents; Lacticaseibacillus casei; Leukemia L1210; Mice; Microbial Sensitivity Tests; Streptococcus; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1986 |
Synthesis of the antileukemic agents 5,10-dideazaaminopterin and 5,10-dideaza-5,6,7,8-tetrahydroaminopterin.
Topics: Amide Synthases; Aminopterin; Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Leukemia; Leukemia L1210; Ligases; Male; Methotrexate; Tetrahydrofolates; Thymidylate Synthase | 1985 |
Triggering liposomal drug release with a lysosomotropic agent.
Topics: Animals; Antibiotics, Antineoplastic; Arylsulfonates; Cell Line, Tumor; Chloroquine; Daunorubicin; Female; Folic Acid; Humans; Hydrogen-Ion Concentration; Leukemia L1210; Liposomes; Lysosomes; Mice; Mice, Inbred DBA; Microscopy, Confocal; Neoplasms | 2010 |
Preparation, therapeutic efficacy and intratumoral localization of targeted daunorubicin liposomes conjugating folate-PEG-CHEMS.
Topics: Animals; Cholesterol; Cholesterol Esters; Daunorubicin; Female; Folic Acid; Leukemia L1210; Liposomes; Mice; Mice, Inbred DBA; Polyethylene Glycols | 2011 |
Decreased expression of the reduced folate carrier and folypolyglutamate synthetase is the basis for acquired resistance to the pemetrexed antifolate (LY231514) in an L1210 murine leukemia cell line.
Topics: Animals; Biological Transport; Carrier Proteins; Down-Regulation; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Gene Silencing; Glutamates; Guanine; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Membrane Transport Proteins; Mice; Pemetrexed; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Reduced Folate Carrier Protein; Tumor Cells, Cultured | 2003 |
Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility.
Topics: Amino Acid Substitution; Animals; Binding Sites; Biological Transport; Carrier Proteins; DNA Primers; Folic Acid; Kinetics; Leukemia L1210; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Recombinant Proteins; Reduced Folate Carrier Protein; Transfection; Tumor Cells, Cultured | 2003 |
ASSOCIATION OF INCREASED DIHYDROFOLATE REDUCTASE LEVELS AND CHROMOSOME ALTERATION IN AMETHOPTERIN-RESISTANT SUBLINES OF LEUKEMIA L1210.
Topics: Animals; Azaserine; Chromosomes; Fluorouracil; Folic Acid; Genetics; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Oxidoreductases; Research; Tetrahydrofolate Dehydrogenase | 1963 |
EFFECT OF AMINES ON DIHYDROFOLATE REDUCTASE.
Topics: Amines; Animals; Cadaver; Ethylenediamines; Folic Acid; Leukemia L1210; Liver; Mice; Oxidoreductases; Proteins; Research; Spermine; Tetrahydrofolate Dehydrogenase | 1963 |
A DIRECT ASSAY FOR DIHYDROFOLATE REDUCTASE IN HUMAN LEUKOCYTES.
Topics: Animals; Chemistry Techniques, Analytical; Folic Acid; Folic Acid Antagonists; Humans; Leukemia; Leukemia L1210; Leukemia, Myeloid; Leukocytes; Methotrexate; Mice; Microchemistry; NADP; Neoplasms; Oxidoreductases; Research; Spectrophotometry; Tetrahydrofolate Dehydrogenase | 1964 |
FURTHER OBSERVATIONS OF THE BINDING AND INHIBITION OF DIHYDROFOLIC REDUCTASE BY FOLIC ACID ANTAGONISTS.
Topics: Aminopterin; Animals; Chromatography; Dialysis; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Hot Temperature; Leukemia L1210; Liver; Methotrexate; Mice; Oxidoreductases; Pharmacology; Potassium; Poultry; Renal Dialysis; Research; Tritium; Urea | 1964 |
DEVELOPMENT AND PROPERTIES OF MOUSE LEUKEMIA L1210 RESISTANT TO MIRACIL D.
Topics: Adenine; Animals; Azaguanine; Cyclophosphamide; Enzyme Inhibitors; Folic Acid; Glutamates; Guanine; Leucovorin; Leukemia L1210; Lucanthone; Mercaptopurine; Methotrexate; Mice; Pharmacology; Proadifen; Pyridoxine; Research; Thioguanine | 1964 |
THE PHARMACOLOGICAL AND BIOCHEMICAL ACTIVITY OF 4-AMINO-4-DEOXY-10-METHYLPTEROYLASPARTIC ACID.
Topics: Adenine; Amino Acids; Animals; Aspartic Acid; Enzyme Inhibitors; Folic Acid; Formates; Kinetics; Leukemia L1210; Liver; Methotrexate; Mice; Oxidoreductases; Pharmacology; Research | 1965 |
Ligand binding and kinetics of folate receptor recycling in vivo: impact on receptor-mediated drug delivery.
Topics: Animals; Carrier Proteins; Disease Models, Animal; Endocytosis; Folate Receptors, GPI-Anchored; Folic Acid; HeLa Cells; Humans; KB Cells; Leukemia L1210; Ligands; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Pentetic Acid; Protein Binding; Receptors, Cell Surface | 2004 |
BGC 945, a novel tumor-selective thymidylate synthase inhibitor targeted to alpha-folate receptor-overexpressing tumors.
Topics: Animals; Apoptosis; Biological Transport; Carrier Proteins; Cell Proliferation; Choriocarcinoma; Enzyme Inhibitors; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Idoxuridine; Iodine Radioisotopes; Leukemia L1210; Lung Neoplasms; Membrane Transport Proteins; Mice; Mice, Nude; Ovarian Neoplasms; Quinazolines; Receptors, Cell Surface; Reduced Folate Carrier Protein; Thymidylate Synthase; Tissue Distribution; Transplantation, Heterologous; Tumor Cells, Cultured | 2005 |
5-fluorouracil-methotrexate synergy: enhancement of 5-fluorodeoxyridylate binding to thymidylate synthase by dihydropteroylpolyglutamates.
Topics: Animals; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Leukemia L1210; Methotrexate; Methyltransferases; Polyglutamic Acid; Protein Binding; Pteroylpolyglutamic Acids; Thymidylate Synthase | 1980 |
The role of methotrexate and dihydrofolate polyglutamates in the enhancement of fluorouracil action by methotrexate.
Topics: Animals; Cell Line; Cell Survival; Drug Administration Schedule; Drug Therapy, Combination; Fluorodeoxyuridylate; Fluorouracil; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Polyglutamic Acid; Pteroylpolyglutamic Acids; Thymidylate Synthase | 1981 |
Biochemical pharmacology of the lipophilic antifolate, trimetrexate.
Topics: Animals; Cell Line; Culture Techniques; Deoxyuridine; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leucovorin; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Mice, Inbred Strains; Quinazolines; Ribonucleotides; Thymidine; Trimetrexate | 1984 |
Polyglutamylation as a factor in the trapping of 5-methyltetrahydrofolate by cobalamin-deficient L1210 cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Cell Division; Escherichia coli; Folic Acid; gamma-Glutamyl Hydrolase; Kinetics; Leucovorin; Leukemia L1210; Mice; Vitamin B 12 Deficiency | 1983 |
Interaction between anions and the reduced folate/methotrexate transport system in L1210 cell plasma membrane vesicles: directional symmetry and anion specificity for differential mobility of loaded and unloaded carrier.
Topics: Animals; Anions; Biological Transport; Cell Fractionation; Cell Membrane; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Oxidation-Reduction | 1984 |
Modulation of anti-metabolite effects. Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB3717.
Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Deoxyuridine; Folic Acid; Leukemia L1210; Male; Methyltransferases; Mice; Mice, Inbred DBA; Quinazolines; Thymidine; Thymidylate Synthase | 1984 |
Transport of the antitumor antibiotic Cl-920 into L1210 leukemia cells by the reduced folate carrier system.
Topics: Alkenes; Animals; Biological Transport; Drug Resistance; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Polyenes; Pyrones; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1984 |
Similar specificity of membrane transport for folate analogues and their metabolites by murine and human tumor cells: a clinically directed laboratory study.
Topics: Animals; Biological Transport; Breast Neoplasms; Cell Line; Cell Membrane; Female; Folic Acid; Humans; Kinetics; Leukemia; Leukemia L1210; Neoplasms; Sarcoma 180; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1984 |
Inhibition of thymidylate synthetase by the new quinazoline antifolate, CB 3717; enzyme purification and kinetics.
Topics: Animals; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methyltransferases; Mice; Quinazolines; Thymidylate Synthase | 1984 |
Plasma nucleoside and base levels following treatment with the new thymidylate synthetase inhibitor CB 3717.
Topics: Animals; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methyltransferases; Mice; Mice, Inbred Strains; Nucleosides; Purines; Pyrimidines; Quinazolines; Thymidylate Synthase | 1984 |
[Evaluation of biochemical criteria for sensitivity of tumor cells to methotrexate by means of mathematic simulation].
Topics: Animals; Carcinoma, Ehrlich Tumor; Folic Acid; Kinetics; Leukemia L1210; Mathematics; Methionine; Methotrexate; Models, Biological; Purines; Serine; Tetrahydrofolate Dehydrogenase; Thymidine Monophosphate | 1980 |
Folate analogues altered in the C9-N10 bridge region. 16. Synthesis and antifolate activity of 11-thiohomoaminopterin.
Topics: Animals; Antineoplastic Agents; Folic Acid; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Mice; Streptococcus; Thymidylate Synthase | 1980 |
[Mathematical description and study of the folic acid cycle reactions].
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Folic Acid; Humans; Kinetics; Leukemia L1210; Mathematics; Methionine; Methotrexate; Mice; Purines; Rats; Serine; Tetrahydrofolate Dehydrogenase; Thymidine Monophosphate | 1980 |
Inhibition of serine metabolism by tetrahydrohomofolate in L1210 mouse leukemia cells.
Topics: Animals; Cell Division; Cells, Cultured; Folic Acid; Glycine Hydroxymethyltransferase; Leukemia L1210; Methionine; Mice; Serine | 1981 |
Relationships between carrier-mediated transport of folate compounds by L1210 leukemia cells: evidence for multiplicity of entry routes with different kinetic properties expressed in plasma membrane vesicles.
Topics: Animals; Biological Transport; Cell Membrane; Cytoplasmic Granules; Diffusion; Drug Resistance; Folic Acid; Formyltetrahydrofolates; Kinetics; Leukemia L1210; Methotrexate; Mice; Structure-Activity Relationship; Tetrahydrofolates | 1983 |
Vitamin B12-dependent replication of L1210 mouse leukemia cells. A model system for cobalamin-folate inter-relationships.
Topics: Animals; Cell Division; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Methionine; Mice; Structure-Activity Relationship; Vitamin B 12 | 1981 |
Two-compartment behavior during transport of folate compounds in L1210 cell plasma membrane vesicles.
Topics: Animals; Biological Transport; Cell Membrane; Cell Membrane Permeability; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Mathematics; Methotrexate; Mice; Models, Biological; Tritium | 1982 |
Accumulation of 5-methyltetrahydrofolate in cobalamin-deficient L1210 mouse leukemia cells.
Topics: Animals; Folic Acid; Leukemia L1210; Mice; Structure-Activity Relationship; Tetrahydrofolates; Vitamin B 12 Deficiency | 1982 |
A convenient procedure for purification of thymidylate synthase from L1210 cells.
Topics: Animals; Folic Acid; Leukemia L1210; Ligands; Methyltransferases; Mice; Thymidylate Synthase | 1982 |
10-Propargylaminopterin and alkyl homologues of methotrexate as inhibitors of folate metabolism.
Topics: Aminopterin; Animals; Antineoplastic Agents; Bacteria; Cells, Cultured; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Membranes; Methotrexate; Mice; Neoplasms, Experimental; Sarcoma 180 | 1982 |
Transport of folate compounds, pterins and adenine in L1210 mouse leukemia cells.
Topics: Adenine; Animals; Biological Transport; Energy Metabolism; Folic Acid; Leukemia L1210; Membranes; Methotrexate; Mice; Neoplasms; Pterins; Tetrahydrofolate Dehydrogenase | 1982 |
A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice.
Topics: Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methyltransferases; Mice; Mice, Inbred C57BL; Quinazolines; Thymidylate Synthase | 1981 |
Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance.
Topics: Animals; Cell Survival; Female; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Quinazolines; Thymidylate Synthase | 1980 |
Quinazoline thymidylate synthase inhibitors: methods for assessing the contribution of polyglutamation to their in vitro activity.
Topics: Animals; Biological Transport; Cell Division; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Folic Acid; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Methotrexate; Peptide Synthases; Polyglutamic Acid; Pteroylpolyglutamic Acids; Quinazolines; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase | 1995 |
Mechanisms of acquired resistance to the quinazoline thymidylate synthase inhibitor ZD1694 (Tomudex) in one mouse and three human cell lines.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Deoxyuracil Nucleotides; Drug Resistance; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Leukemia L1210; Lymphocytes; Methotrexate; Mice; Neoplasm Proteins; Ovarian Neoplasms; Peptide Synthases; Polyglutamic Acid; Proteins; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1995 |
Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity.
Topics: Acyltransferases; Animals; Biological Transport, Active; Carrier Proteins; Cell Division; Enzyme Inhibitors; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Hydroxymethyl and Formyl Transferases; Leucovorin; Leukemia; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Mice; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Receptors, Cell Surface; Reduced Folate Carrier Protein; Structure-Activity Relationship; Substrate Specificity; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Conjugates of folate and anti-T-cell-receptor antibodies specifically target folate-receptor-positive tumor cells for lysis.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Carrier Proteins; Cell Line; Cytotoxicity, Immunologic; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Immunoconjugates; Kinetics; Leukemia L1210; Leukemia, Experimental; Mice; Mice, Inbred DBA; Receptors, Antigen, T-Cell; Receptors, Cell Surface; T-Lymphocytes, Cytotoxic; Tumor Cells, Cultured | 1995 |
Role of membrane-associated folate binding protein in the cytotoxicity of antifolates in KB, IGROV1, and L1210A cells.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Drug Interactions; Drug Screening Assays, Antitumor; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; KB Cells; Leucovorin; Leukemia L1210; Membrane Proteins; Mice; Ovarian Neoplasms; Receptors, Cell Surface; Tumor Cells, Cultured | 1995 |
Inhibition of murine amido phosphoribosyltransferase by folate derivatives.
Topics: Amidophosphoribosyltransferase; Animals; Centrifugation, Density Gradient; Folic Acid; Leukemia L1210; Macromolecular Substances; Mice; Tumor Cells, Cultured | 1994 |
Quinazoline antifolate thymidylate synthase inhibitors: replacement of glutamic acid in the C2-methyl series.
Topics: Animals; Antineoplastic Agents; Folic Acid; Folic Acid Antagonists; Glutamic Acid; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase.
Topics: Animals; Cell Survival; Deoxyadenine Nucleotides; Drug Interactions; Floxuridine; Folic Acid; Hypoxanthine; Hypoxanthines; Leukemia L1210; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1995 |
Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells.
Topics: Alkenes; Animals; Biological Transport; Carrier Proteins; Energy Metabolism; Folate Receptors, GPI-Anchored; Folic Acid; Hydrogen-Ion Concentration; Ions; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Polyenes; Probenecid; Pyrones; Receptors, Cell Surface; Reduced Folate Carrier Protein; Sulfobromophthalein; Temperature; Transfection; Tumor Cells, Cultured | 1995 |
Structural preferences among folate compounds and their analogues for ATPase-mediated efflux by inside-out plasma membrane vesicles derived from L1210 cells.
Topics: Adenosine Triphosphatases; Animals; Cell Line; Cell Membrane; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice | 1995 |
Disposition of leucovorin and its metabolites in the plasma, intestinal epithelium, and intraperitoneal L1210 cells of methotrexate-pretreated mice.
Topics: Animals; Epithelium; Female; Folic Acid; Intestinal Mucosa; Leucovorin; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Peritoneum; Tumor Cells, Cultured | 1994 |
The synthesis and thymidylate synthase inhibitory activity of L-gamma-L-linked dipeptide and L-gamma-amide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Topics: 2-Aminoadipic Acid; Animals; Binding Sites; Cell Division; Dipeptides; Drug Stability; Folic Acid; Glutamic Acid; Hydrolases; Hydrolysis; Leukemia L1210; Mice; Structure-Activity Relationship; Thymidylate Synthase | 1994 |
The in vivo metabolic stability of dipeptide analogues of the quinazoline antifolate, ICI 198583, in mice.
Topics: Animals; Dipeptides; Drug Stability; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Stereoisomerism; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Gamma-linked dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8- dideazafolate as antitumour agents.
Topics: Animals; Antineoplastic Agents; Dipeptides; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase | 1993 |
Substituted-2-desamino-2-methyl-quinazolinones. A series of novel antitumour agents.
Topics: Animals; Antineoplastic Agents; Cell Division; Drug Screening Assays, Antitumor; Folic Acid; Leukemia L1210; Mice; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
Quinazoline antifolates inhibiting thymidylate synthase: synthesis of gamma-linked peptide and amide analogues of 2-desamino-2-methyl-N10-propargyl- 5,8-dideazafolic acid (ICI 198583).
Topics: Animals; Cell Division; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Molecular Structure; Peptides; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 1993 |
The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.
Topics: Animals; Antineoplastic Agents; Cell Division; Deoxyuracil Nucleotides; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thiophenes; Thymidylate Synthase; Thymine Nucleotides | 1993 |
Quinazoline antifolate thymidylate synthase inhibitors: gamma-linked L-D, D-D, and D-L dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Topics: Animals; Antineoplastic Agents; Cell Division; Dipeptides; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; Quinazolines; Stereoisomerism; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 1996 |
Intestinal folate transport: identification of a cDNA involved in folate transport and the functional expression and distribution of its mRNA.
Topics: Animals; Base Sequence; Carrier Proteins; Cell Line; DNA, Complementary; Female; Folate Receptors, GPI-Anchored; Folic Acid; Gene Expression; Humans; Intestinal Absorption; Leukemia L1210; Mice; Molecular Sequence Data; Oocytes; Rats; Receptors, Cell Surface; RNA, Messenger; Sequence Analysis, DNA; Xenopus laevis | 1996 |
Design and synthesis of histidine analogues of folic acid and methotrexate as potential folylpolyglutamate synthetase inhibitors.
Topics: Animals; Cell Division; Folic Acid; Folic Acid Antagonists; Histidine; Humans; Hydrogen-Ion Concentration; Leukemia L1210; Methotrexate; Mice; Peptide Synthases | 1996 |
Novel substrate analogs delineate an endocytotic mechanism for uptake of folate via the high-affinity, glycosylphosphatidylinositol-linked transport protein in L1210 mouse leukemia cells.
Topics: Animals; Bacterial Proteins; Biological Transport; Biotin; Carrier Proteins; Cell Membrane; Endocytosis; Fluoresceins; Folate Receptors, GPI-Anchored; Folic Acid; Glycosylphosphatidylinositols; Gold; Leukemia L1210; Mice; Receptors, Cell Surface; Tritium | 1995 |
Folate-based inhibitors of thymidylate synthase: synthesis and antitumor activity of gamma-linked sterically hindered dipeptide analogues of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583).
Topics: Animals; Antineoplastic Agents; Cell Division; Dipeptides; Enzyme Inhibitors; Folic Acid; Leukemia L1210; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Thymidylate Synthase | 1997 |
Biotin derivatives of folate compounds: synthesis and utilization for visualization and affinity purification of folate transport proteins.
Topics: Animals; Bacterial Proteins; Biological Transport; Biotin; Carrier Proteins; Chromatography, Affinity; Electrophoresis, Polyacrylamide Gel; Fluorescein; Fluoresceins; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Microscopy; Molecular Structure; Receptors, Cell Surface; Sepharose; Tumor Cells, Cultured | 1997 |
Impact of overexpression of the reduced folate carrier (RFC1), an anion exchanger, on concentrative transport in murine L1210 leukemia cells.
Topics: Animals; Anions; Biological Transport; Carrier Proteins; Folic Acid; Formyltetrahydrofolates; Leukemia L1210; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Polyglutamic Acid | 1997 |
A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.
Topics: Amino Acid Substitution; Animals; Anions; Binding Sites; Biological Transport, Active; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Glutamic Acid; Kinetics; Leukemia L1210; Lysine; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis, Site-Directed; Protein Structure, Secondary; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Mutations in the reduced folate carrier gene which confer dominant resistance to 5,10-dideazatetrahydrofolate.
Topics: Animals; Biological Transport; Carrier Proteins; Cell Division; DNA Mutational Analysis; Drug Resistance; Folate Receptors, GPI-Anchored; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Methotrexate; Mice; Phenotype; Point Mutation; Pteroylpolyglutamic Acids; Receptors, Cell Surface; RNA, Messenger; Tetrahydrofolates; Transcription, Genetic; Transfection; Tumor Cells, Cultured | 1998 |
Cellular folates prevent polyglutamation of 5, 10-dideazatetrahydrofolate. A novel mechanism of resistance to folate antimetabolites.
Topics: Animals; Biological Transport; Cell Division; Drug Resistance; Feedback; Folic Acid; Hydroxymethyl and Formyl Transferases; Kinetics; Leukemia L1210; Mice; Peptide Synthases; Phenotype; Phosphoribosylglycinamide Formyltransferase; Pteroylpolyglutamic Acids; RNA, Messenger; Tetrahydrofolates; Tumor Cells, Cultured | 1998 |
Characterization of folate transport mediated by a low pH route in mouse L1210 leukemia cells with defective reduced folate carrier function.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; Ammonium Chloride; Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Kinetics; Leukemia L1210; Methotrexate; Mice; Monensin; Nigericin; Receptors, Cell Surface; Tumor Cells, Cultured; Valinomycin | 1998 |
A novel class of lipophilic quinazoline-based folic acid analogues: cytotoxic agents with a folate-independent locus.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Division; Cell Survival; Chemical Precipitation; Colony-Forming Units Assay; Cytoprotection; DNA, Neoplasm; Folic Acid; Humans; Leukemia L1210; Lipid Metabolism; Mice; Quinazolines; Solubility; Tumor Cells, Cultured | 1999 |
Potentiation of the cytotoxicity of thymidylate synthase (TS) inhibitors by dipyridamole analogues with reduced alpha1-acid glycoprotein binding.
Topics: Animals; Antineoplastic Agents; Biological Transport; Cell Division; Cell Survival; Dipyridamole; Drug Synergism; Enzyme Inhibitors; Folic Acid; Leukemia L1210; Mice; Molecular Structure; Orosomucoid; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured | 1999 |
Role of the amino acid 45 residue in reduced folate carrier function and ion-dependent transport as characterized by site-directed mutagenesis.
Topics: Amino Acid Substitution; Animals; Anions; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Folic Acid; Glutamic Acid; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis, Site-Directed; Reduced Folate Carrier Protein; Tetrahydrofolates; Transfection; Tumor Cells, Cultured | 2000 |
Characterization of a human alternatively spliced truncated reduced folate carrier increasing folate accumulation in parental leukemia cells.
Topics: 3' Untranslated Regions; Alternative Splicing; Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cell Division; DNA Primers; DNA, Complementary; DNA, Neoplasm; Folic Acid; Humans; Leukemia; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Models, Molecular; Molecular Sequence Data; Reduced Folate Carrier Protein; RNA, Messenger; RNA, Neoplasm; Transfection; Tumor Cells, Cultured | 2000 |
Contrasting effects of oncogene expression on two carrier-mediated systems internalizing folate compounds in Fisher rat 3T3 cells.
Topics: Animals; Base Sequence; Biological Transport, Active; Carrier Proteins; Cell Line; DNA Primers; Folic Acid; Gene Expression; Genes, myc; Genes, ras; Hydrogen-Ion Concentration; Kinetics; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Rats; Reduced Folate Carrier Protein; Transfection | 2000 |
The mechanism of transport of the multitargeted antifolate (MTA) and its cross-resistance pattern in cells with markedly impaired transport of methotrexate.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Carrier Proteins; Cell Division; Drug Resistance, Neoplasm; Folic Acid; Folic Acid Antagonists; Glutamates; Guanine; Leucovorin; Leukemia L1210; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Prostaglandins A | 2000 |
Marked suppression of the activity of some, but not all, antifolate compounds by augmentation of folate cofactor pools within tumor cells.
Topics: Animals; Biological Transport; Cell Division; Folic Acid; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Mice; Polyglutamic Acid; Tumor Cells, Cultured | 2001 |
Folate uptake in L1210 cells: mediation by an adenine transport system.
Topics: 1-Methyl-3-isobutylxanthine; Adenine; Animals; Biological Transport, Active; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice | 1979 |
Synthesis of aza homologues of folic acid.
Topics: Animals; Antineoplastic Agents; Folic Acid; Humans; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Leukemia, Lymphoid; Male; Mice; Pediococcus; Streptococcus; Thymidylate Synthase | 1979 |
Quinazoline analogues of folic acid as inhibitors of thymidylate synthetase from bacterial and mammalian sources.
Topics: Animals; Cell Division; Folic Acid; In Vitro Techniques; Lacticaseibacillus casei; Leukemia L1210; Methyltransferases; Mice; Neoplasms, Experimental; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1979 |
Cytotoxicity of 5-fluoro-2'-deoxyuridine: requirement for reduced folate cofactors and antagonism by methotrexate.
Topics: Animals; Cells, Cultured; Floxuridine; Folic Acid; Leukemia L1210; Methotrexate | 1978 |
The isolation of dihydrofolate reductases by affinity chromatography on folate-sepharose.
Topics: Animals; Cell Line; Chromatography, Affinity; Folic Acid; Humans; Lacticaseibacillus casei; Leukemia; Leukemia L1210; Leukocytes; Methotrexate; Mice; Sepharose; Tetrahydrofolate Dehydrogenase | 1977 |
Antitumor properties of a new folate analog, 10-deaza-aminopterin, in mice.
Topics: Aminopterin; Animals; Carcinoma, Ehrlich Tumor; Drug Evaluation, Preclinical; Female; Folic Acid; Leukemia L1210; Liver Neoplasms; Male; Methotrexate; Mice; Neoplasms, Experimental; Plasmacytoma; Sarcoma 180 | 1978 |
Folate analog transport by plasma membrane vesicles isolated from L1210 leukemia cells.
Topics: Aminopterin; Animals; Biological Transport; Cell Membrane; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Structure-Activity Relationship | 1979 |
Polyglutamyl and polylysyl derivatives of the lysine analogues of folic acid and homofolic acid.
Topics: Animals; Escherichia coli; Folic Acid; In Vitro Techniques; Leukemia L1210; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1976 |
A direct ligand-binding radioassay for the measurement of methotrexate in tissues and biological fluids.
Topics: Animals; Binding Sites; Dose-Response Relationship, Drug; Folic Acid; Humans; Leukemia L1210; Mercaptoethanol; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; NADPH-Ferrihemoprotein Reductase; Radioligand Assay; Stimulation, Chemical; Tetrahydrofolate Dehydrogenase | 1975 |
Quinazolines as inhibitors of dihydrofolate reductase. 4. Classical analogues of folic and isofolic acids.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Liver; Mice; Quinazolines; Rats; Streptococcus; Structure-Activity Relationship | 1977 |
Sycnthesis of quinazoline analogues of folic acid modified at postion 10.
Topics: Animals; Antineoplastic Agents; Folic Acid; Leukemia L1210; Mice; Quinazolines | 1977 |
Folate metabolism in mammalian cells in culture. I Partial characterization of the folate derivatives present in L1210 mouse leukemia cells.
Topics: Animals; Carboxypeptidases; Cell Division; Cells, Cultured; Folic Acid; Kidney; Kinetics; Leukemia L1210; Oxidation-Reduction; Swine; Time Factors | 1976 |
Polyglutamate forms of folate: natural occurrence and role as substrates in mammalian cells.
Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Animals; Brain; Cattle; Erythrocytes; Folic Acid; Glutamates; Humans; Kinetics; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Mice; Oligopeptides; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1976 |
Aspects of the biochemical pharmacology of cytembena.
Topics: Acrylates; Animals; Cell Division; DNA Nucleotidyltransferases; DNA, Neoplasm; Dose-Response Relationship, Drug; Folic Acid; Formate-Tetrahydrofolate Ligase; Glycine Hydroxymethyltransferase; Humans; In Vitro Techniques; Leucine; Leucovorin; Leukemia L1210; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Rats; Sarcoma, Yoshida; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidine; Thymidine Kinase; Thymidylate Synthase; Uridine | 1975 |
Interaction of chemotherapeutic agents with methotrexate and 5-fluorouracil and its effect on de novo DNA synthesis.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Cephalosporins; Dexamethasone; DNA; DNA, Neoplasm; Fluorouracil; Folic Acid; Glucocorticoids; Humans; Hydrocortisone; Idoxuridine; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Mice, Inbred DBA; Prednisolone; Prednisone; Vincristine | 1975 |
Synthesis of quinazoline analogs of isofolic acid.
Topics: Animals; Folic Acid; Folic Acid Antagonists; In Vitro Techniques; Leukemia L1210; Liver; Mice; Quinazolines; Rats; Structure-Activity Relationship | 1975 |
Biochemical and biological studies on 2-desamino-2-methylaminopterin, an antifolate the polyglutamates of which are more potent than the monoglutamate against three key enzymes of folate metabolism.
Topics: Acyltransferases; Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Hepatocellular; Cell Division; Drug Administration Schedule; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Male; Methotrexate; Mice; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Quinazolines; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Multiple folate transport systems in L1210 cells.
Topics: Animals; Biotin; Carrier Proteins; Chromatography, Affinity; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface; Tumor Cells, Cultured | 1992 |
Interconversion of tetrahydrofolate cofactors to dihydrofolate induced by trimetrexate after suppression of thymidylate synthase by fluorodeoxyuridine in L1210 leukemia cells.
Topics: Animals; Computer Simulation; Deoxyuridine; DNA; Enzyme Reactivators; Floxuridine; Folic Acid; Folic Acid Antagonists; Leucovorin; Leukemia L1210; Mice; Purines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Time Factors; Trimetrexate; Tumor Cells, Cultured | 1992 |
Quinoline antifolate thymidylate synthase inhibitors: variation of the C2- and C4-substituents.
Topics: Animals; Cell Survival; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Binding Sites; Cell Division; Crystallization; Drug Design; Escherichia coli; Folic Acid; Humans; Imidazoles; Leukemia; Leukemia L1210; Mice; Molecular Structure; Quinolines; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
DNA fragmentation, dATP pool elevation and potentiation of antifolate cytotoxicity in L1210 cells by hypoxanthine.
Topics: Animals; Deoxyadenine Nucleotides; DNA Damage; Drug Synergism; Folic Acid; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Leukemia L1210; Methotrexate; Mice; Tumor Cells, Cultured | 1992 |
N-[4-[[(3,4-dihydro-4-oxo-1,2,3-benzotriazin-6- yl)methyl]amino]benzoyl]-L-glutamic acid, a novel A-ring analogue of 2-desamino-5,8-dideazafolic acid.
Topics: Acyltransferases; Animals; Antineoplastic Agents; Folic Acid; Hydroxymethyl and Formyl Transferases; Leukemia L1210; Liver; Mice; Peptide Synthases; Phosphoribosylglycinamide Formyltransferase; Recombinant Proteins; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Membrane transport of natural folates and antifolate compounds in murine L1210 leukemia cells: role of carrier- and receptor-mediated transport systems.
Topics: Animals; Carrier Proteins; Cell Membrane; Folate Receptors, GPI-Anchored; Folic Acid; Formyltetrahydrofolates; Leukemia L1210; Methotrexate; Receptors, Cell Surface; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1991 |
Synthesis and antifolate evaluation of the 10-propargyl derivatives of 5-deazafolic acid, 5-deazaaminopterin, and 5-methyl-5-deazaaminopterin.
Topics: Aminopterin; Animals; Cell Division; Folic Acid; Folic Acid Antagonists; Humans; Leukemia L1210; Mammary Neoplasms, Experimental; Mice; Quinazolines; Thymidylate Synthase; Tumor Cells, Cultured | 1992 |
Rate and extent of interconversion of tetrahydrofolate cofactors to dihydrofolate after cessation of dihydrofolate reductase activity in stationary versus log phase L1210 leukemia cells.
Topics: Animals; Cell Cycle; DNA, Neoplasm; Flow Cytometry; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Quinazolines; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thermodynamics; Trimetrexate; Tumor Cells, Cultured | 1991 |
Compartmentation of intracellular folates. Failure to interconvert tetrahydrofolate cofactors to dihydrofolate in mitochondria of L1210 leukemia cells treated with trimetrexate.
Topics: Animals; Cell Compartmentation; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Mitochondria; Quinazolines; Tetrahydrofolates; Trimetrexate; Tumor Cells, Cultured | 1991 |
Inhibition of 2-desamino-2-methyl-10-propagyl-5,8-dideazafolic acid cytotoxicity by 5,10-dideazatetrahydrofolate in L1210 cells with decrease in DNA fragmentation and deoxyadenosine triphosphate pools.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Cell Survival; Deoxyadenine Nucleotides; DNA, Neoplasm; Drug Antagonism; Folic Acid; Folic Acid Antagonists; Hypoxanthine; Hypoxanthines; Leukemia L1210; Mice; Tetrahydrofolates; Thymine Nucleotides; Tumor Cells, Cultured | 1991 |
Biotin derivatives of methotrexate and folate. Synthesis and utilization for affinity purification of two membrane-associated folate transporters from L1210 cells.
Topics: Animals; Biological Transport; Biotin; Carrier Proteins; Chromatography, Affinity; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Mice; Receptors, Cell Surface; Tumor Cells, Cultured | 1991 |
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study.
Topics: Animals; Carrier Proteins; Cell Division; Drug Screening Assays, Antitumor; Folate Receptors, GPI-Anchored; Folic Acid; Glutamates; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred DBA; Quinazolines; Receptors, Cell Surface; Thiophenes; Thymidylate Synthase | 1991 |
Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues.
Topics: Animals; Cell Division; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 1991 |
Role for cytosolic folate-binding proteins in the compartmentation of endogenous tetrahydrofolates and the 5-formyl tetrahydrofolate-mediated enhancement of 5-fluoro-2'-deoxyuridine antitumor activity in vitro.
Topics: Adenocarcinoma; Animals; Carrier Proteins; Cell Division; Chromatography, Gel; Colonic Neoplasms; Floxuridine; Folic Acid; Humans; Leucovorin; Leukemia L1210; Tetrahydrofolates | 1990 |
Quinazoline folate analogs inhibit the catalytic activity of thymidylate synthase but allow binding of 5-fluorodeoxyuridylate.
Topics: Animals; Binding Sites; Cytidine Monophosphate; Floxuridine; Fluorodeoxyuridylate; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Mice; Models, Structural; Protein Binding; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1990 |
Quinazoline antifolate thymidylate synthase inhibitors: alkyl, substituted alkyl, and aryl substituents in the C2 position.
Topics: Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Chemistry, Physical; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Liver; Mice; Molecular Structure; Quinazolines; Rats; Structure-Activity Relationship; Thymidylate Synthase | 1990 |
Quinazoline antifolate thymidylate synthase inhibitors: 2'-fluoro-N10-propargyl-5,8-dideazafolic acid and derivatives with modifications in the C2 position.
Topics: Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Drug Resistance; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Molecular Structure; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1990 |
Identification of cholate as a shared substrate for the unidirectional efflux systems for methotrexate in L1210 mouse cells.
Topics: Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cholic Acids; Cytochalasin B; Folic Acid; Glucose; Leukemia L1210; Methotrexate; Mice; Probenecid; Substrate Specificity; Sulfobromophthalein; Temperature; Tumor Cells, Cultured; Uric Acid; Vincristine | 1990 |
Characteristics of a novel transport system for folate compounds in wild-type and methotrexate-resistant L1210 cells.
Topics: Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone; Cell Division; Drug Resistance; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Mice; Tumor Cells, Cultured | 1990 |
Growth inhibition by homofolate in tumor cells utilizing a high-affinity folate binding protein as a means for folate internalization.
Topics: Animals; Antineoplastic Agents; Carrier Proteins; Cell Division; Folic Acid; Growth Inhibitors; Kinetics; Leukemia L1210; Methotrexate; Mice; Tumor Cells, Cultured | 1990 |
Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Drug Resistance; Folic Acid; Humans; Kinetics; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Structure-Activity Relationship; Thymidylate Synthase; Tumor Cells, Cultured | 1990 |
Syntheses and antifolate activity of 5-methyl-5-deaza analogues of aminopterin, methotrexate, folic acid, and N10-methylfolic acid.
Topics: Aminopterin; Animals; Bacteria; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Leukemia P388; Methotrexate; Mice; Polyglutamic Acid; Structure-Activity Relationship | 1986 |
Biochemical and pharmacologic basis for potentiation of 5-fluorouracil action by leucovorin.
Topics: Animals; Biotransformation; Cell Division; Colonic Neoplasms; DNA; Drug Synergism; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia L1210; Mice; RNA; Stomach Neoplasms; Thymidine; Thymidylate Synthase | 1987 |
Development of an assay for the estimation of N10-propargyl-5,8-dideazafolic acid polyglutamates in tumor cells.
Topics: Animals; Chromatography, High Pressure Liquid; Folic Acid; Leukemia L1210; Mice; Neoplasms; Peptides; Polyglutamic Acid; Quinazolines; Thymidylate Synthase | 1988 |
Formation and retention and biological activity of N10-propargyl-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro.
Topics: Animals; Biotransformation; Chromatography, High Pressure Liquid; Folic Acid; Leukemia L1210; Mice; Peptides; Polyglutamic Acid; Quinazolines; Thymidylate Synthase; Time Factors | 1988 |
Further studies on the pharmacologic effects of the 7-hydroxy catabolite of methotrexate in the L1210 murine leukemia cell.
Topics: Animals; Deoxyuridine; Folic Acid; Folic Acid Antagonists; Formates; Leucovorin; Leukemia L1210; Methotrexate; Mice; Polyglutamic Acid; Tumor Cells, Cultured | 1989 |
Rescue effect of exogenous reduced folates on methotrexate polyglutamylation and dihydrofolate reductase activity in L1210 cells.
Topics: Animals; Folic Acid; Formyltetrahydrofolates; Leukemia L1210; Methotrexate; Mice; Peptides; Polyglutamic Acid; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Tumor Cells, Cultured | 1988 |
Cobalamin-dependent replication of L1210 leukemia cells and effects of cobalamin analogues.
Topics: Animals; Ascorbic Acid; Cell Division; Cobalt Radioisotopes; Cobamides; Culture Media; Folic Acid; Growth Inhibitors; Hydroxocobalamin; Leukemia L1210; Mice; Serum Albumin, Bovine; Vitamin B 12; Vitamin B 12 Deficiency | 1989 |
Folate analogues. 31. Synthesis of the reduced derivatives of 11-deazahomofolic acid, 10-methyl-11-deazahomofolic acid, and their evaluation as inhibitors of glycinamide ribonucleotide formyltransferase.
Topics: Acyltransferases; Animals; Antineoplastic Agents; Cell Division; Chemical Phenomena; Chemistry; Folic Acid; Humans; Hydroxymethyl and Formyl Transferases; Lacticaseibacillus casei; Leukemia; Leukemia L1210; Mice; Molecular Structure; Phosphoribosylglycinamide Formyltransferase; Purines; Stereoisomerism; Streptococcus; Structure-Activity Relationship; Tumor Cells, Cultured | 1989 |
Visualization of membrane-associated folate transport proteins.
Topics: Animals; Carrier Proteins; Cell Membrane; Folate Receptors, GPI-Anchored; Folic Acid; Immunohistochemistry; Lacticaseibacillus casei; Leukemia L1210; Mice; Microscopy, Electron; Receptors, Cell Surface | 1989 |
Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts.
Topics: Acyltransferases; Animals; Folic Acid; Humans; Hydroxymethyl and Formyl Transferases; Kinetics; Leukemia L1210; Lymphoma; Mice; Molecular Conformation; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Pteroylpolyglutamic Acids; Quinazolines; Structure-Activity Relationship; Trimetrexate | 1989 |
Enhancement of trimetrexate cytotoxicity in vitro and in vivo by carboxypeptidase G2.
Topics: Animals; Cell Line; Cell Survival; Clone Cells; Cysteine Endopeptidases; Drug Resistance; Drug Synergism; Folic Acid; gamma-Glutamyl Hydrolase; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Quinazolines; Trimetrexate; Tumor Stem Cell Assay | 1989 |
Folate-pool interconversions and inhibition of biosynthetic processes after exposure of L1210 leukemia cells to antifolates. Experimental and network thermodynamic analyses of the role of dihydrofolate polyglutamylates in antifolate action in cells.
Topics: Animals; Computer Simulation; Deoxyuridine; Floxuridine; Folic Acid; Folic Acid Antagonists; Formates; Leukemia L1210; Methotrexate; Mice; Purines; Pyrimidines; Quinazolines; Tetrahydrofolates; Thermodynamics; Thymidylate Synthase; Trimetrexate | 1989 |
Mediation of cellular anion detoxification in leukemic cells by unidirectional efflux pumps.
Topics: Animals; Anions; Biological Transport; Cholic Acids; Cyclic AMP; Drug Resistance; Folic Acid; Leukemia L1210; Methotrexate; Tumor Cells, Cultured; Uric Acid | 1989 |
Estimation of the in vitro and in vivo inhibitory effects of antifolates upon thymidylate synthase (TS) in whole cells.
Topics: Animals; Dose-Response Relationship, Drug; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Mice; Mice, Inbred DBA; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase; Time Factors; Tumor Cells, Cultured | 1989 |
Expression of a folate binding protein in L1210 cells grown in low folate medium.
Topics: Animals; Biological Transport; Carrier Proteins; Culture Media; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Methotrexate; Receptors, Cell Surface; Tumor Cells, Cultured | 1989 |
Quinazoline antifolates inhibiting thymidylate synthase: 2-desamino derivatives with enhanced solubility and potency.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Hydrogen Bonding; Leukemia L1210; Liver; Quinazolines; Rats; Solubility; Structure-Activity Relationship; Thymidylate Synthase | 1989 |
Comparison of the biological effects of selected 5,8-dideazafolate analogues with their 2-desamino counterparts.
Topics: Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Quinazolines; Structure-Activity Relationship; Thymidylate Synthase | 1989 |
Relationship of reduced folate changes to inhibition of DNA synthesis induced by methotrexate in L1210 cells in vivo.
Topics: Animals; DNA, Neoplasm; Female; Folic Acid; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA | 1989 |
A comparison of dihydrofolate reductase activity in intact leukemia cells and squamous cell carcinoma.
Topics: Animals; Biological Transport; Carcinoma, Squamous Cell; Cell Count; DNA, Neoplasm; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Oxidation-Reduction; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tumor Cells, Cultured | 1989 |
Further studies on a novel class of genetic variants of the L1210 cell with increased folate analogue transport inward. Transport properties of a new variant, evidence for increased levels of a specific transport protein, and its partial characterization
Topics: Affinity Labels; Aminopterin; Animals; Biological Transport; Carrier Proteins; Cell Division; Cell Membrane; Cholic Acids; Chromatography; Drug Resistance; Electrophoresis, Polyacrylamide Gel; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Variation; Kinetics; Leukemia L1210; Methotrexate; Molecular Weight; Pyrimethamine; Receptors, Cell Surface; Succinimides | 1988 |
Increased thymidylate synthase in L1210 cells possessing acquired resistance to N10-propargyl-5,8-dideazafolic acid (CB3717): development, characterization, and cross-resistance studies.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Deoxyuridine; Drug Resistance; Floxuridine; Fluorouracil; Folic Acid; Folic Acid Antagonists; Hypoxanthine; Hypoxanthines; Kinetics; Leukemia L1210; Mice; Quinazolines; Thymidylate Synthase; Tritium | 1986 |
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells.
Topics: Animals; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Floxuridine; Fluorouracil; Folic Acid; Humans; Leucovorin; Leukemia; Leukemia L1210; Mice | 1986 |
The effects on 4-aminoantifolates on 5-formyltetrahydrofolate metabolism in L1210 cells. A biochemical basis of the selectivity of leucovorin rescue.
Topics: Adenosine; Animals; Cell Division; Floxuridine; Folic Acid; Kinetics; Leucovorin; Leukemia L1210; Mice; Thymidine | 1987 |
Membrane-associated folate transport proteins.
Topics: Animals; Carrier Proteins; Cell Membrane; Chromatography, DEAE-Cellulose; Chromatography, Gel; Folate Receptors, GPI-Anchored; Folic Acid; Indicators and Reagents; Lacticaseibacillus casei; Leukemia L1210; Mice; Radioisotope Dilution Technique; Receptors, Cell Surface; Tritium | 1986 |
Analogues of folate antagonists as affinity and fluorescent probes of dihydrofolate reductase structure and function.
Topics: Affinity Labels; Animals; Folic Acid; Leukemia L1210; Lysine; Methotrexate; Mice; Ornithine; Tetrahydrofolate Dehydrogenase; X-Ray Diffraction | 1986 |
Folate analogues. 26. Syntheses and antifolate activity of 10-substituted derivatives of 5,8-dideazafolic acid and of the poly-gamma-glutamyl metabolites of N10-propargyl-5,8-dideazafolic acid (PDDF).
Topics: Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Lacticaseibacillus casei; Leukemia L1210; Quinazolines; Streptococcus; Structure-Activity Relationship; Thymidylate Synthase | 1986 |
Antibody for detection and quantitation of membrane-associated folate-binding protein from Lactobacillus casei.
Topics: Animals; Antibodies; Biological Transport; Carrier Proteins; Cell Membrane; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Folate Receptors, GPI-Anchored; Folic Acid; Lacticaseibacillus casei; Leukemia L1210; Microscopy, Electron; Rabbits; Receptors, Cell Surface | 1987 |
Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative.
Topics: Acyltransferases; Animals; Anti-Bacterial Agents; Folic Acid; Folic Acid Antagonists; Hydroxymethyl and Formyl Transferases; Indicators and Reagents; Lacticaseibacillus casei; Leukemia L1210; Mice; Microbial Sensitivity Tests; Phosphoribosylaminoimidazolecarboxamide Formyltransferase; Phosphoribosylglycinamide Formyltransferase; Streptococcus; Structure-Activity Relationship; Tetrahydrofolates; Thymidylate Synthase | 1988 |
Role of methylenetetrahydrofolate depletion in methotrexate-mediated intracellular thymidylate synthesis inhibition in cultured L1210 cells.
Topics: Animals; Folic Acid; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolates; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1988 |
Mediated uptake of folate by a high-affinity binding protein in sublines of L1210 cells adapted to nanomolar concentrations of folate.
Topics: Adaptation, Physiological; Animals; Biological Transport, Active; Carrier Proteins; Cell Division; Cell Line; Folate Receptors, GPI-Anchored; Folic Acid; Leukemia L1210; Receptors, Cell Surface | 1988 |
Growth and DNA synthesis of folate- and methionine-depleted L1210 mouse leukemia cells in culture.
Topics: Animals; Cell Division; Cells, Cultured; Deoxyuridine; DNA; Folic Acid; Leucovorin; Leukemia L1210; Methionine; Mice | 1987 |
Enhancement of folate analogue transport inward in L1210 cells during methotrexate therapy of leukemic mice: evidence of the nature of the effect, possible host mediation, and pharmacokinetic significance.
Topics: Affinity Labels; Animals; Biological Transport; Cycloheximide; Dose-Response Relationship, Drug; Folic Acid; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Succinimides | 1987 |
Analysis of thymidylate synthase gene amplification and of mRNA levels in the cell cycle.
Topics: Animals; Cell Cycle; Cell Line; DNA; Folic Acid; Folic Acid Antagonists; Gene Amplification; Leukemia L1210; Mice; Nucleic Acid Hybridization; Quinazolines; RNA, Messenger; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase | 1987 |
Carrier-mediated transport of folate compounds in L1210 cells. Initial rate kinetics and extent of duality of entry routes for folic acid and diastereomers of 5-methyltetrahydrohomofolate in the presence of physiological anions.
Topics: Animals; Anions; Binding, Competitive; Biological Transport; Carrier Proteins; Cell Line; Folate Receptors, GPI-Anchored; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Receptors, Cell Surface; Stereoisomerism | 1987 |
Synthesis and biological activities of 5-deaza analogues of aminopterin and folic acid.
Topics: Aminopterin; Animals; Folic Acid; Leukemia L1210; Magnetic Resonance Spectroscopy; Mice; Spectrophotometry, Ultraviolet | 1986 |
The biochemical pharmacology of CI-920, a structurally novel antibiotic with antileukemic activity.
Topics: Alkenes; Animals; Antibiotics, Antineoplastic; Cell Line; Cell Survival; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerases; Flow Cytometry; Folic Acid; Leukemia L1210; Mice; Neoplasms, Experimental; Nucleotides; Polyenes; Pyrones; Structure-Activity Relationship | 1985 |
Extent of the requirement for folate transport by L1210 cells for growth and leukemogenesis in vivo.
Topics: Animals; Folic Acid; Leucovorin; Leukemia L1210; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation | 1985 |
Preclinical chemotherapy: historical aspects.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Folic Acid; History, 20th Century; Leucovorin; Leukemia L1210; Neoplasms, Experimental | 1985 |
Activity of the new antifolate N10-propargyl-5,8-dideazafolate and its polyglutamates against human dihydrofolate reductase, human thymidylate synthetase, and KB cells containing different levels of dihydrofolate reductase.
Topics: Animals; Cell Division; Drug Resistance; Folic Acid; Folic Acid Antagonists; Humans; KB Cells; Lacticaseibacillus casei; Leukemia L1210; Mathematics; Methotrexate; Methyltransferases; Pteroylpolyglutamic Acids; Quinazolines; Thymidylate Synthase | 1985 |
Effects of methotrexate on folates in Krebs ascites and L1210 murine leukemia cells.
Topics: Animals; Carcinoma, Krebs 2; Cells, Cultured; Folic Acid; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Mice, Inbred ICR; Tetrahydrofolates | 1986 |
Transport of folate compounds in L1210 cells: kinetic evidence that folate influx proceeds via the high-affinity transport system for 5-methyltetrahydrofolate and methotrexate.
Topics: Animals; Biological Transport; Cells, Cultured; Chromatography, Thin Layer; Drug Contamination; Folic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Tetrahydrofolates; Tritium | 1986 |
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
Topics: Aminopterin; Animals; Cells, Cultured; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasms; Pteroylpolyglutamic Acids; Tumor Stem Cell Assay | 1985 |
Folic acid analogs. Modifications in the benzene-ring region. 4. 3'-Ethyl- and 3'-isopropylfolic acids.
Topics: Animals; Columbidae; Enterococcus faecalis; Ethane; Folic Acid; In Vitro Techniques; Leukemia L1210; Mice; Microbial Sensitivity Tests; Propane; Protein Binding; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1974 |
Synthesis of 1-deaza-N10-methylfolic acid and related compounds.
Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Carcinoma; Cell Line; Columbidae; Enterococcus faecalis; Folic Acid; Folic Acid Antagonists; Humans; Lacticaseibacillus casei; Leukemia L1210; Liver; Mouth Neoplasms | 1974 |
Studies with a mathematical model of folate metabolism.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Floxuridine; Folic Acid; Formates; Glycine; Hydrolases; Kinetics; Leukemia L1210; Mathematics; Methotrexate; Models, Biological; Oxidoreductases; Pentosephosphates; Purines; Serine; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymidylate Synthase; Time Factors; Transferases | 1973 |
Dihydrofolate reductase from the L1210R murine lymphoma. Fluorometric measurements of the interaction of the enzyme with coenzymes, substrates, and inhibitors.
Topics: Animals; Chemical Phenomena; Chemistry; Enzymes; Fluorometry; Folic Acid; Leukemia L1210; Lymphoma; Methotrexate; Mice; NADP; Triamterene | 1966 |
Dihydrofolate reductase from the L1210 R murine lymphoma. Further studies on the binding of substrates and inhibitors to the enzyme.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry, Physical; Fluorometry; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Leukemia L1210; Methotrexate; Mice; NADP; Protein Binding; Pyrimidines; Tetrahydrofolate Dehydrogenase; Triamterene | 1967 |
"Induction" of dihydrofolate reductase: purification and properties of the "induced" human erythrocyte and leukocyte enzyme and normal bone marrow enzyme.
Topics: Animals; Bone Marrow; Bone Marrow Cells; Chromatography; Enzyme Activation; Enzyme Induction; Erythrocytes; Folic Acid; Humans; Hydrogen-Ion Concentration; Immune Sera; Leukemia L1210; Leukocytes; Methotrexate; Molecular Weight; NAD; NADP; Neoplasms; Protein Denaturation; Tetrahydrofolate Dehydrogenase | 1970 |
Purification of tetrahydrofolate dehydrogenase by affinity chromatography.
Topics: Alkylation; Ammonium Sulfate; Animals; Buffers; Cell Line; Chemical Precipitation; Chromatography, Affinity; Chromatography, Gel; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Leukemia L1210; Methods; Methotrexate; NADP; Osmolar Concentration; Polysaccharides; Protein Binding; Spectrophotometry; Tetrahydrofolate Dehydrogenase; Ultraviolet Rays | 1972 |
Dihydrofolate reductase from mouse liver and spleen. Purification, properties and inhibition by substituted 2,4-diaminopyrimidines and 4,6-diaminotriazines.
Topics: Animals; Antigen-Antibody Reactions; Cell Line; Chromatography; Chromatography, Gel; Enzyme Activation; Folic Acid; Folic Acid Antagonists; Guanidines; Hot Temperature; Hydrogen-Ion Concentration; Kinetics; Leukemia L1210; Liver; Lymphoma; Methotrexate; Mice; Mice, Inbred Strains; NADP; Potassium Chloride; Protein Denaturation; Pyrimidines; Spleen; Tetrahydrofolate Dehydrogenase; Triazines; Urea | 1971 |
Effects of sulfhydryl inhibitors upon transport of folate compounds into L1210 cells.
Topics: Animals; Benzenesulfonates; Cells, Cultured; Folic Acid; Folic Acid Antagonists; Iodoacetates; Kinetics; Leukemia L1210; Mercury; Methotrexate; Mice; Organometallic Compounds; Sulfhydryl Reagents; Tetrahydrofolates; Time Factors | 1974 |
The effect of replacement of methionine by homocystine on survival of malignant and normal adult mammalian cells in culture.
Topics: Animals; Breast; Carcinoma 256, Walker; Cell Division; Cell Line; Cell Survival; Cells, Cultured; Culture Media; Female; Fibroblasts; Folic Acid; Homocystine; Humans; Leukemia L1210; Leukemia, Experimental; Leukemia, Myeloid; Liver; Male; Methionine; Mice; Prostate; Rats; Vitamin B 12 | 1974 |
7,8-Dihydropteroyl oligo-gamma-L-glutamates: synthesis and kinetic studies with purified dihydrofolate reductase from mammalian sources.
Topics: Animals; Erythrocytes; Folic Acid; Humans; Kinetics; Leukemia L1210; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Methotrexate; Mice; Oxidation-Reduction; Polycythemia Vera; Spleen; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1974 |
Factors determining cell sensitivity to methotrexate: studies of folate and deoxyribonucleoside triphosphate pools in five mammalian cell lines.
Topics: Animals; Biological Assay; Cell Count; Cell Line; Cells, Cultured; Deoxyadenosines; Deoxyribonucleotides; Dose-Response Relationship, Drug; Folic Acid; Humans; L Cells; Leukemia L1210; Lymphoma; Methotrexate; Methylenetetrahydrofolate Dehydrogenase (NADP); Mice; Rats; Sarcoma, Yoshida; Thymidine; Thymidylate Synthase | 1974 |
Folate antagonists covalently linked to carbohydrates: synthesis, properties, and use in the purification of dihydrofolate reductases.
Topics: Aminopterin; Animals; Cell Line; Cellulose; Chemical Phenomena; Chemistry; Chickens; Chromatography, Affinity; Chromatography, Gel; Dextrans; Folic Acid; Folic Acid Antagonists; Hydrogen-Ion Concentration; Lacticaseibacillus casei; Leukemia L1210; Liver; Methotrexate; Mice; Molecular Weight; Polysaccharides; Protein Binding; Spectrophotometry; Starch; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays | 1972 |
Folic acid analogs. Modifications in the benzene-ring region. 2. Thiazole analogs.
Topics: Animals; Carcinoma; Cell Line; Chromatography, Thin Layer; Columbidae; Enterococcus faecalis; Folic Acid; Folic Acid Antagonists; Humans; Laryngeal Neoplasms; Leukemia L1210; Liver; Magnetic Resonance Spectroscopy; Malaria; Mice; Plasmodium berghei; Structure-Activity Relationship; Thiazoles | 1972 |
Folic acid analogs. Modifications in the benzene-ring region. 3. Neohomofolic and neobishomofolic acids. An improved synthesis of folic acid and its analogs.
Topics: Animals; Aza Compounds; Chemical Phenomena; Chemistry; Chromatography, DEAE-Cellulose; Columbidae; Folic Acid; Folic Acid Antagonists; Hydrolysis; Leukemia L1210; Liver; Methods; Mice; Neoplasm Transplantation; Transplantation, Homologous | 1973 |
Interaction of thymidylate synthetase and dihydrofolate reductase enzymes in vitro and in vivo.
Topics: Animals; Cells, Cultured; Deoxyuridine; DNA, Neoplasm; Drug Interactions; Folic Acid; Leukemia L1210; Methotrexate; Methyltransferases; Mice; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Tritium | 1974 |
Stereochemical characteristics of the folate-antifolate transport mechanism in L1210 Leukemia cells.
Topics: Aminopterin; Animals; Biological Transport, Active; Cells, Cultured; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Mice; Pyrimidines; Quinazolines | 1974 |
Studies with tetrahydrohomofolate and thymidylate synthetase from amethopterin-resistant mouse leukemia cells.
Topics: Animals; Carbon Isotopes; Chemical Precipitation; Chromatography, Gel; Deoxyuridine; Drug Stability; Escherichia coli; Folic Acid; Leukemia L1210; Ligases; Methotrexate; Mice; Nucleotides; Spleen; Splenic Neoplasms; Tetrahydrofolate Dehydrogenase | 1968 |
Pharmacologic aspects of homofolate derivatives in relation to amethopterin-resistant murine leukemia.
Topics: Animals; Antineoplastic Agents; Biological Assay; Enterococcus faecalis; Folic Acid; Leukemia L1210; Ligases; Male; Methotrexate; Mice; Nucleotides; Tetrahydrofolate Dehydrogenase | 1966 |
On the biochemical mechanism of action of tetrahydrohomofolic acid.
Topics: Animals; Carbon Isotopes; Cell Line; Deoxyuridine; Depression, Chemical; DNA; Drug Resistance; Folic Acid; Formates; Leukemia L1210; Male; Mice; Orotic Acid; Spleen; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Thymine; Tritium | 1972 |
Uptake and metabolism of N 5 -formyltetrahydrofolate by L1210 leukemia cells.
Topics: Animals; Carbon Isotopes; Chloromercuribenzoates; Chromatography, Gel; Coenzymes; Depression, Chemical; Fluorides; Folic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Iodoacetates; Leukemia L1210; Methotrexate; Mice; Ouabain; Tetrahydrofolates; Tritium | 1972 |
The mechanism of folate transport in rabbit reticulocytes.
Topics: Animals; Azides; Biological Transport, Active; Erythrocytes; Folic Acid; Iodoacetates; Kinetics; Leukemia L1210; Methotrexate; Rabbits; Reticulocytes; Tetrahydrofolates | 1972 |
Lack of intracellular conversion of dihydrohomofolate to tetrahydrohomofolate in leukemia cells with high levels of dihydrofolate reductase.
Topics: Animals; Cells, Cultured; Chromatography, DEAE-Cellulose; Folic Acid; Leukemia L1210; Male; Methotrexate; Mice; Mice, Inbred Strains; Oxidation-Reduction; Spectrum Analysis; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays | 1972 |
Antitumor activity of a folate-cleaving enzyme, carboxypeptidase G 1 .
Topics: Animals; Antineoplastic Agents; Carboxypeptidases; Carcinoma 256, Walker; Cell Division; Cell Line; Cells, Cultured; Clone Cells; Deoxyuridine; Depression, Chemical; DNA, Neoplasm; Female; Folic Acid; Folic Acid Deficiency; Humans; Injections, Intraperitoneal; Leukemia L1210; Liver; Lymphoma; Male; Mice; Mice, Inbred AKR; Mice, Inbred DBA; Mice, Inbred Strains; Neoplasms, Experimental; Rats; Sarcoma 180; Thymidine; Time Factors; Tritium | 1972 |
The return of antimetabolite sensitivity in methotrexate- and 6-mercaptopurine-resistant L1210 murine leukemia by the process of adaptive selection.
Topics: Animals; Cell Line; Cells, Cultured; Crosses, Genetic; Drug Resistance; Female; Folic Acid; Genetic Variation; Hypoxanthines; Leukemia L1210; Male; Mercaptopurine; Methotrexate; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Pentosyltransferases; Selection, Genetic; Tetrahydrofolate Dehydrogenase; Transplantation, Homologous | 1972 |
A model system for the study of heteroexchange diffusion: methotrexate-folate interactions in L1210 leukemia and Ehrlich ascites tumor cells.
Topics: Animals; Binding Sites; Biological Transport; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell Line; Cell Membrane; Cells, Cultured; Chromatography, DEAE-Cellulose; Diffusion; Folic Acid; Folic Acid Antagonists; Formates; Kinetics; Leukemia L1210; Methotrexate; Methylation; Mice; Models, Biological; Tritium | 1971 |
Effect of pretreatment with methotrexate on the reduction of dihydrohomofolic acid in mice.
Topics: Animals; Chromatography, DEAE-Cellulose; Folic Acid; Kidney; Leukemia L1210; Liver; Male; Methotrexate; Mice; Spleen; Stereoisomerism; Tetrahydrofolate Dehydrogenase | 1971 |
Effect of tetrahydrohomofolate on DNA biosynthesis in leukemic mice.
Topics: Animals; Carbon Isotopes; DNA; Folic Acid; Formates; Kidney; Leukemia L1210; Liver; Male; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Orotic Acid; Spleen | 1971 |
Sites of action of amethopterin: intrinsic and acquired drug resistance.
Topics: Animals; Binding Sites; Biological Transport; Cells, Cultured; DNA, Neoplasm; Drug Resistance; Female; Folic Acid; Kinetics; Leukemia L1210; Lymphoma; Methotrexate; Protein Binding; Rats; Sarcoma, Yoshida; Tetrahydrofolate Dehydrogenase; Time Factors; Tritium; Uridine | 1971 |
The characteristics of the membrane transport of amethopterin and the naturally occurring folates.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Aspirin; Azides; Biological Transport, Active; Carcinoma, Ehrlich Tumor; Cell Membrane; Cells, Cultured; Chlorides; Erythrocytes; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Nitrates; Organophosphorus Compounds; Phosphates; Rabbits; Sulfates; Time Factors | 1971 |
Carrier-mediated transport of the folic acid analogue, methotrexate, in the L1210 leukemia cell.
Topics: Animals; Biological Transport, Active; Cell Membrane Permeability; Culture Techniques; Depression, Chemical; Folic Acid; Folic Acid Antagonists; Kinetics; Leucovorin; Leukemia L1210; Membrane Potentials; Methotrexate; Mice; Temperature; Tetrahydrofolate Dehydrogenase | 1968 |
Inhibition of growth of leukemia cells by enzymic folate depletion.
Topics: Animals; Carboxypeptidases; Carcinoma 256, Walker; Cell Line; Culture Media; Depression, Chemical; Folic Acid; Humans; Hypoxanthines; In Vitro Techniques; Leucovorin; Leukemia L1210; Leukemia, Experimental; Methotrexate; Pseudomonas; Serine; Thymidine | 1971 |
Enzymic preparations of radiolabeded (+)-L-5-methyltetrahydrofolate and (+)-L-5-formyltetrahydrofolate.
Topics: Animals; Carbon Isotopes; Cell Line; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Clostridium; Folic Acid; Isotope Labeling; Leucovorin; Leukemia L1210; Methods; Methylation; Oxidation-Reduction; Oxidoreductases; Spectrophotometry; Stereoisomerism; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays | 1971 |
Enzyme studies with new analogues of folic acid and homofolic acid.
Topics: Amino Acids; Animals; Enzymes; Escherichia coli; Folic Acid; Glutamates; Kinetics; Leukemia L1210; Ligases; Models, Theoretical; Tetrahydrofolate Dehydrogenase | 1967 |
Characteristics of folic acid transport in the L1210 leukemia cell.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Culture Techniques; Folic Acid; Folic Acid Antagonists; Kinetics; Leukemia L1210; Methotrexate; Nitrogen; Oxygen; Time Factors; Tritium | 1969 |
Distribution studies of tetrahydrohomofolic acid (NSC 89473) in mice.
Topics: Animals; Bile; Brain Chemistry; Chromatography; Erythrocytes; Folic Acid; Intestines; Kidney; Leukemia L1210; Liver; Lung; Methotrexate; Mice; Muscles; Myocardium; Spectrophotometry; Spleen | 1970 |
Riboflavin-methotrexate interactions. Photochemical reaction and competition for transport in the L1210 mouse leukemia cell.
Topics: Animals; Biological Transport; Cell Line; Cell Membrane Permeability; Chromatography, DEAE-Cellulose; Ethanol; Flavins; Folic Acid; Kinetics; Leukemia L1210; Light; Methotrexate; Mice; Photochemistry; Protein Binding; Radiation Effects; Riboflavin; Spectrophotometry; Temperature; Tetrahydrofolate Dehydrogenase; Tritium; Ultraviolet Rays | 1970 |
Amethopterin resistance in clonal lines of L1210 mouse leukemia: some associated biologic and biochemical alterations.
Topics: Animals; Chromosomes; Folic Acid; Leukemia L1210; Methotrexate; Mice; Oxidoreductases | 1966 |
Growth of L1210 mouse leukemia cells in vitro.
Topics: Animals; Chromosomes; Culture Techniques; Fluorouracil; Folic Acid; Leukemia L1210; Mercaptopurine; Methotrexate; Mice; Microscopy | 1966 |
An isotopic assay for thymidylate synthetase.
Topics: Animals; Folic Acid; In Vitro Techniques; Leukemia L1210; Ligases; Mercaptoethanol; Mice; Tritium; Uracil Nucleotides | 1966 |