Page last updated: 2024-08-17

folic acid and Intellectual Disability

folic acid has been researched along with Intellectual Disability in 86 studies

Research

Studies (86)

Timeframe	Studies, this research(%)	All Research%
pre-1990	61 (70.93)	18.7374
1990's	9 (10.47)	18.2507
2000's	10 (11.63)	29.6817
2010's	6 (6.98)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Ao, M; Fukuwatari, T; Kitagawa, M; Kumode, M; Kuwabara, A; Makino, S; Miyawaki, T; Nagae, A; Tanaka, K	1
Dalman, C; DeVilbiss, EA; Gardner, RM; Lee, BK; Lyall, K; Magnusson, C; Newschaffer, CJ; Rai, D	1
Benoist, JF; Lubetzki, C; Masingue, M; Moussa, F; Nadjar, Y; Roze, E; Sedel, F	1
Cauli, O; González-Guevara, L; Guevara-Campos, J	1
Baumgartner, MR; Burda, P; Chinnery, PF; Demirkol, M; Dionisi-Vici, C; Dobbelaere, D; Fowler, B; Froese, DS; Gökcay, G; Häberle, J; Huemer, M; Lossos, A; Mengel, E; Morris, AA; Mulder-Bleile, R; Niezen-Koning, KE; Parini, R; Plecko, B; Rokicki, D; Schiff, M; Schimmel, M; Sewell, AC; Sperl, W; Spiekerkoetter, U; Steinmann, B; Suormala, T; Taddeucci, G; Trefz, F; Trejo-Gabriel-Galán, JM; Tsuji, M; Vilaseca, MA; von Kleist-Retzow, JC; Walker, V; Zeev, BB; Zeman, J	1
Artuch, R; Espinós, C; Lupo, V; Martínez-Rubio, D; Ormazabal, A; Palau, F; Pineda, M; Spaapen, LJ; Vilaseca, MA	1
Chatterjee, A; Dutta, S; Mukhopadhyay, K; Sarkar, K; Shaw, J; Sinha, S; Usha, R	1
Artigas-Pallarés, J; Brun-Gasca, C	1
Blau, N; Bonafé, L; Häusler, M; Kierat, L; Krägeloh-Mann, I; Ramaekers, V; Thöny, B	1
ALBUM, MM	1
Bacino, CA; Blau, N; Bottiglieri, T; Curry, S; del Gaudio, D; Finnell, RH; Hyland, K; Miller, G; Moretti, P; Neul, JL; Peters, S; Ramaekers, VT; Roa, B; Sahoo, T; Scaglia, F; Zhu, H	1
Butron, M; Castro del Río, M; Navarro, C; Puig, M; Ribes, A; Seijo-Martínez, M; Vila, O	1
Ecer, S; Katar, S; Nuri Ozbek, M; Yaramiş, A	1
Cole, PD; Kamen, BA	1
Finnell, RH; Harris, JA; Jelliffe-Pawlowski, L; Nelson, V; Shaw, GM; Zhu, H	1
Bacino, CA; Bottiglieri, T; Del Gaudio, D; Goldman, D; Hopkin, RJ; Hyland, K; Min, SH; Moretti, P; Peach, E; Peters, SU; Roa, B; Sahoo, T; Scaglia, F	1
Komrower, GM	1
Hecht, F; Jacky, PB; Sutherland, GR	1
Nielsen, KB; Tommerup, N	1
Auger, M; Giraud, F; Mattei, JF; Mattei, MG	1
Sutherland, GR	2
Shojania, AM	1
Glover, TW	1
Boué, J; Gilgenkrantz, S; Grégoire, MJ; Tejada, I	1
Alliende, MA; Curotto, B; De Andraca, I; Lacassie, Y; Zavala, A	1
Morizon, G; Santos, M	1
Erbe, RW; Wang, JC	1
Beck, B; Brandt, NJ; Christensen, E; Pedersen, M	1
Harpey, JP	1
Lejeune, J	2
de Bree, PK; Duran, M; Ketting, D; Penders, TJ; van Sprang, FJ; Wadman, SK; Wilms, RH	1
Lejeune, J; Peeters, MA; Rethore, MO	1
Deb, S	1
Chudley, AE; Evans, JA; Samadder, P	1
Cuckle, H; Hewison, J; Murray, J; Taylor, G	1
Bassan, H; Fattal-Valevski, A; Gutman, A; Harel, S; Korman, SH; Lerman-Sagie, T	1
Johnson, I; Rose, M	1
Siva Sankar, DV	1
McBride, G	1
Turner, G; Wilcken, B	1
Reynolds, EH	2
Fricke, NL; Springer, NS	1
Cameron, JD; Eastham, RD; Jancar, J	1
Hall, CA	1
Jordan, BR	1
Beaver, WT; Bottomley, WK; Brown, RS; Di Stanislao, PT	1
Evans, JL; Howell, RT; McDermott, A	1
Cheang, M; Chudley, AE; Evans, JA; Ray, M	1
Bénézech, M; Bonnaure, C; Moulin, B; Noël, B; Nougier, B; Quack, B; Suerinck-Neoussikhin, E	1
Airaksinen, E; Alitalo, T; Kähkönen, M; Kaski, M; Matilainen, R; Tengström, C	1
Bäckman, N; Blomquist, HK; Hänström, L; Heijbel, J; Holm, AK; Säfström, G	1
Colantuoni, M; de Tollis, G; Della Monica, M; Fiore, M; Gentile, G; Lonardo, F; Perone, L; Sirone, P; Stabile, M; Ventruto, V	1
Curry, CJ; Froster-Iskenius, U; Hall, JG	1
Chodirker, BN; Chudley, AE; Ray, M; Riordan, DL; Wickstrom, DE	1
Fryns, JP; Petit, P	1
Cowie, VA; Deb, S; Richens, A	1
Andermann, E; Duschenes, EA; Golick, MS; Hellstrom, FV; Rosenblatt, DS; Vekemans, MJ; Zeesman, SF	1
de la Cruz, FF	1
Fryns, JP; Hecht, F; Petit, P; van den Berghe, H	1
Corbeel, L; Eeckels, R; Jaeken, J; Van den Berghe, G; Van Tornout, J	1
Ahmed, I; Akinyanju, O; Goddell, JC	1
Sviatkina, OB; Vel'tishchev, IuE	1
Arakawa, T; Honda, Y; Yoshida, T	1
Kanfer, JN; McCluer, R; Miller, JD	1
Arakawa, T; Hirono, H; Honda, Y; Narisawa, K; Yoshida, T	1
Germano, G; Scholer, Y	1
Bezan, AI; Erlandson, ME; Lanzkowsky, P	1
Moe, PJ; Wefring, KW	1
Hommes, OR; Houben, PF; Knaven, PJ	1
Arakawa, T; Hirooka, Y; Narisawa, K; Ono, T; Tanno, K	1
Arakawa, T	1
Neubauer, C	1
Lommen, EJ; Schretlen, ED; Trijbels, JM; van der Zee, SP	1
Kane, FJ; Lipton, M	1
Kariks, J; Perry, SW	1
Dergachev, VV; Khamaganova, TG; Krasnushkina, NA; Pivovarova, GN; Shaginian, EV	1
Newcombe, DS	1
Sinclair, S; Verma, IC	1
Couvreur, J; De Montis, G; Gaultier, C; Gerbeaux, J; Steinschneider, R; Tournier, G; Vialas, M	1
Herbert, V	1
Arakawa, T; Chiba, R; Hayashi, T; Mizuno, T; Ogasawara, J; Ohara, K; Okamura, T; Tada, K; Takahashi, Y; Wada, Y; Yoshida, T	1
Arakawa, T; Fujii, M; Hirono, H; Karahashi, M; Kobayashi, M; Ohara, K; Watanabe, S	1
Carey, M; Fennelly, JJ; FitzGerald, O	1

Reviews

11 review(s) available for folic acid and Intellectual Disability

Article	Year
Delayed neurotoxicity associated with therapy for children with acute lymphoblastic leukemia. Mental retardation and developmental disabilities research reviews, 2006, Volume: 12, Issue:3 Topics: Antineoplastic Agents; Brain; Child; Cranial Irradiation; Demyelinating Diseases; Developmental Disabilities; Folic Acid; Humans; Intellectual Disability; Neuropsychological Tests; Neurotoxicity Syndromes; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Radiation Injuries; Risk Factors	2006
The fragile X chromosome: current methods. American journal of medical genetics, 1982, Volume: 11, Issue:4 Topics: Cells, Cultured; Chromosome Fragility; Chromosome Mapping; Female; Fibroblasts; Floxuridine; Folic Acid; Genetic Carrier Screening; Humans; Intellectual Disability; Lymphocytes; Male; Pregnancy; Prenatal Diagnosis; Sex Chromosome Aberrations; Sex Chromosomes; X Chromosome	1982
[Mental retardation linked to fragility of chromosome X: current knowledge]. Journal de genetique humaine, 1984, Volume: 32, Issue:3 Topics: Bromodeoxyuridine; Child; Chromosome Banding; Ear, External; Face; Floxuridine; Folic Acid; Fragile X Syndrome; Gene Frequency; Genetic Linkage; Glucosephosphate Dehydrogenase; Humans; Intellectual Disability; Lymphocytes; Male; Pedigree; Prenatal Diagnosis; Sex Chromosome Aberrations	1984
The fragile X chromosome. International review of cytology, 1983, Volume: 81 Topics: Adolescent; Birth Weight; Bone Marrow; Child; Child, Preschool; Chromosome Banding; Culture Techniques; Dosage Compensation, Genetic; Female; Fibroblasts; Folic Acid; Fragile X Syndrome; Genetic Carrier Screening; Genetic Counseling; Genetic Linkage; Humans; Intellectual Disability; Karyotyping; Lymphocytes; Male; Middle Aged; Phenotype; Sex Chromosome Aberrations	1983
Folic acid and vitamin B12 deficiency in pregnancy and in the neonatal period. Clinics in perinatology, 1984, Volume: 11, Issue:2 Topics: Abortion, Spontaneous; Anemia; Congenital Abnormalities; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant, Newborn; Infant, Premature; Intellectual Disability; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy Complications, Hematologic; Vitamin B 12; Vitamin B 12 Deficiency	1984
Screening for fragile X syndrome: information needs for health planners. Journal of medical screening, 1997, Volume: 4, Issue:2 Topics: Adolescent; Adult; Blotting, Southern; Child; Child, Preschool; Female; Folic Acid; Fragile X Syndrome; Genetics, Population; Humans; Infant; Infant, Newborn; Intellectual Disability; Male; Mass Screening; Mosaicism; Mutation; Neonatal Screening; Polymerase Chain Reaction; Pregnancy; Prenatal Diagnosis; Prevalence	1997
Neurological aspects of folate and vitamin B12 metabolism. Clinics in haematology, 1976, Volume: 5, Issue:3 Topics: Adult; Aged; Anemia, Megaloblastic; Anticonvulsants; Blood-Brain Barrier; Brain; Brain Diseases; Child; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Formiminoglutamic Acid; Humans; Intellectual Disability; Male; Mental Disorders; Metabolism, Inborn Errors; Methotrexate; Middle Aged; Nervous System Diseases; Vitamin B 12; Vitamin B 12 Deficiency	1976
Nutrition and drug therapy for persons with developmental disabilities. American journal of mental deficiency, 1975, Volume: 80, Issue:3 Topics: Anticonvulsants; Antidepressive Agents; Appetite; Dextroamphetamine; Drug-Related Side Effects and Adverse Reactions; Folic Acid; Growth; Humans; Hyperkinesis; Intellectual Disability; Metabolism, Inborn Errors; Methylphenidate; Nutritional Physiological Phenomena; Pyridoxine; Tranquilizing Agents; Vitamin B 12; Vitamin D; Vitamins	1975
Fragile X-linked mental retardation and the difficulties of reverse genetics. BioEssays : news and reviews in molecular, cellular and developmental biology, 1991, Volume: 13, Issue:5 Topics: Animals; Cells, Cultured; Chromosome Mapping; Cricetinae; Crossing Over, Genetic; DNA; DNA Mutational Analysis; Female; Folic Acid; Fragile X Syndrome; Genes, Recessive; Genetic Markers; Genetic Vectors; Heterozygote; Humans; Hybrid Cells; Intellectual Disability; Male; Models, Genetic; Pedigree; Phenotype; Polymorphism, Restriction Fragment Length; Saccharomyces cerevisiae; X Chromosome	1991
Fragile X syndrome. American journal of mental deficiency, 1985, Volume: 90, Issue:2 Topics: Adolescent; Child; Female; Folic Acid; Fragile X Syndrome; Genetic Counseling; Genetic Markers; Heterozygote; Humans; Infant; Intellectual Disability; Male; Phenotype; Prenatal Diagnosis; Sex Chromosome Aberrations; Testis	1985
[Hereditary anomalies of methionine metabolism in children]. Pediatriia, 1972, Volume: 51, Issue:4 Topics: Age Factors; Child; Flatfoot; Folic Acid; Homocysteine; Homocystine; Homocystinuria; Humans; Intellectual Disability; Kyphosis; Marfan Syndrome; Metabolism, Inborn Errors; Methionine; Scoliosis	1972

Trials

4 trial(s) available for folic acid and Intellectual Disability

Article	Year
[Metabolism of monocarbons and the fragile X syndrome]. Bulletin de l'Academie nationale de medecine, 1981, Volume: 165, Issue:9 Topics: Adolescent; Adult; Child; Child, Preschool; Chromosome Fragility; Clinical Trials as Topic; Deanol; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Hydroxocobalamin; Intellectual Disability; Leucovorin; Male; Mental Disorders	1981
The administration of folic acid to institutionalized epileptic adults with phenytoin-induced gingival hyperplasia. A double-blind, randomized, placebo-controlled, parallel study. Oral surgery, oral medicine, and oral pathology, 1991, Volume: 71, Issue:5 Topics: Adult; Dental Care for Disabled; Dental Plaque Index; Double-Blind Method; Epilepsy; Female; Folic Acid; Gingival Hyperplasia; Humans; Intellectual Disability; Male; Periodontal Index; Phenytoin	1991
Folate treatment of diphenylhydantoin-induced gingival hyperplasia. Scandinavian journal of dental research, 1989, Volume: 97, Issue:3 Topics: Adolescent; Child; Epilepsy; Female; Folic Acid; Gingival Hyperplasia; Humans; Intellectual Disability; Male; Phenytoin; Random Allocation	1989
Folic acid blinded trial in identical twins with fragile X syndrome. American journal of human genetics, 1985, Volume: 37, Issue:3 Topics: Adolescent; Clinical Trials as Topic; Diseases in Twins; Female; Folic Acid; Fragile X Syndrome; Humans; Intellectual Disability; Intelligence Tests; Learning; Male; Perception; Pregnancy; Psychometrics; Sex Chromosome Aberrations; Twins; Twins, Monozygotic	1985

Other Studies

71 other study(ies) available for folic acid and Intellectual Disability

Article	Year
Gastric and Jejunal Enteral Feeding Differently Affect Vitamin B Journal of nutritional science and vitaminology, 2019, Volume: 65, Issue:6 Topics: Adult; Cross-Sectional Studies; Enteral Nutrition; Female; Folic Acid; Humans; Intellectual Disability; Jejunum; Male; Middle Aged; Motor Disorders; Stomach; Vitamin B 12; Vitamin B 6	2019
Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study. BMJ (Clinical research ed.), 2017, Oct-04, Volume: 359 Topics: Adolescent; Autism Spectrum Disorder; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Humans; Intellectual Disability; Iron; Male; Nutritional Support; Outcome Assessment, Health Care; Pregnancy; Pregnancy Outcome; Prenatal Nutritional Physiological Phenomena; Prevalence; Statistics as Topic; Sweden; Vitamins	2017
Cerebral folate deficiency in adults: A heterogeneous potentially treatable condition. Journal of the neurological sciences, 2019, 01-15, Volume: 396 Topics: Adolescent; Adult; Aged; Calcinosis; Cerebellar Diseases; Child; Child, Preschool; Female; Folic Acid; Folic Acid Deficiency; Follow-Up Studies; Humans; Infant; Infant, Newborn; Intellectual Disability; Magnetic Resonance Imaging; Male; Middle Aged; Mitochondrial Diseases; Mutation; Proteins; Retrospective Studies; Tetrahydrofolates; White Matter; Young Adult	2019
Autism and intellectual disability associated with mitochondrial disease and hyperlactacidemia. International journal of molecular sciences, 2015, Feb-11, Volume: 16, Issue:2 Topics: Carnitine; Child Development Disorders, Pervasive; Child, Preschool; Female; Folic Acid; Humans; Hyperlactatemia; Infant; Intellectual Disability; Male; Mitochondrial Diseases; Ubiquinone; Vitamins	2015
Clinical pattern, mutations and in vitro residual activity in 33 patients with severe 5, 10 methylenetetrahydrofolate reductase (MTHFR) deficiency. Journal of inherited metabolic disease, 2016, Volume: 39, Issue:1 Topics: Ataxia; Betaine; Child; Female; Folic Acid; Genetic Association Studies; Homocystinuria; Humans; Intellectual Disability; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Mutation; Phenotype; Psychotic Disorders; Retrospective Studies; Spinal Cord Diseases; Vitamin B 12	2016
Mutations in the urocanase gene UROC1 are associated with urocanic aciduria. Journal of medical genetics, 2009, Volume: 46, Issue:6 Topics: Amino Acid Metabolism, Inborn Errors; Amino Acid Sequence; Ataxia; Biomarkers; Child; Computer Simulation; Female; Folic Acid; Histidine; Humans; Intellectual Disability; Models, Molecular; Molecular Sequence Data; Mutation; Sequence Alignment; Urocanate Hydratase; Urocanic Acid	2009
Importance of gene variants and co-factors of folate metabolic pathway in the etiology of idiopathic intellectual disability. Nutritional neuroscience, 2011, Volume: 14, Issue:5 Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Epistasis, Genetic; Family Health; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Variation; Humans; Intellectual Disability; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Restriction Fragment Length; Tetrahydrofolate Dehydrogenase; Vitamin B 6; Young Adult	2011
[Medical treatment of fragile X syndrome]. Revista de neurologia, 2001, Volume: 33 Suppl 1 Topics: Adrenergic alpha-Agonists; Anticonvulsants; Antipsychotic Agents; Attention Deficit and Disruptive Behavior Disorders; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Child; Clonidine; Epilepsy; Folic Acid; Fragile X Syndrome; Humans; Intellectual Disability; Selective Serotonin Reuptake Inhibitors	2001
Cerebrospinal fluid pterins and folates in Aicardi-Goutières syndrome: a new phenotype. Neurology, 2003, Sep-09, Volume: 61, Issue:5 Topics: Basal Ganglia; Brain Diseases; Decalcification, Pathologic; DNA Mutational Analysis; Dyskinesias; Female; Fibroblasts; Folic Acid; Humans; Infant; Infant, Newborn; Intellectual Disability; Intracellular Signaling Peptides and Proteins; Leucovorin; Male; Microcephaly; Muscle Hypertonia; Phenotype; Proteins; Psychomotor Disorders; Pterins; Seizures; Syndrome; Tomography, X-Ray Computed	2003
The effect of vitamins on the gingival tissue of handicapped children. Oral surgery, oral medicine, and oral pathology, 1957, Volume: 10, Issue:2 Topics: Ascorbic Acid; Cerebral Palsy; Child; Disabled Children; Folic Acid; Gingivitis; Humans; Infant; Intellectual Disability; Vitamin A; Vitamin B Complex; Vitamin K; Vitamins	1957
Cerebral folate deficiency with developmental delay, autism, and response to folinic acid. Neurology, 2005, Mar-22, Volume: 64, Issue:6 Topics: Adaptation, Physiological; Autistic Disorder; Cerebral Cortex; Child; Developmental Disabilities; Disease Progression; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Intellectual Disability; Leucovorin; Mutation; Recovery of Function; Reduced Folate Carrier Protein; Seizures; Tetrahydrofolates; Transcription Factors; Treatment Outcome	2005
L-2-hydroxyglutaric aciduria: clinical, neuroimaging, and neuropathological findings. Archives of neurology, 2005, Volume: 62, Issue:4 Topics: Adolescent; Atrophy; Brain; Brain Diseases, Metabolic, Inborn; Epilepsy; Fatal Outcome; Folic Acid; Genes, Recessive; Glutarates; Humans; Intellectual Disability; Magnetic Resonance Imaging; Male; Mesenteric Vascular Occlusion; Mesenteric Veins; Nerve Fibers, Myelinated; Spain	2005
Nutritional megaloblastic anemia in young Turkish children is associated with vitamin B-12 deficiency and psychomotor retardation. Journal of pediatric hematology/oncology, 2006, Volume: 28, Issue:9 Topics: Anemia, Megaloblastic; Child, Preschool; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Intellectual Disability; Male; Motor Skills Disorders; Neutrophils; Turkey; Vitamin B 12; Vitamin B 12 Deficiency	2006
Infant C677T MTHFR polymorphism and severe mental retardation. Birth defects research. Part A, Clinical and molecular teratology, 2007, Volume: 79, Issue:1 Topics: Alleles; Congenital Abnormalities; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homozygote; Humans; Infant; Infant, Newborn; Intellectual Disability; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors	2007
Brief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and dyskinesias in CNS folate deficiency. Journal of autism and developmental disorders, 2008, Volume: 38, Issue:6 Topics: Adolescent; Autistic Disorder; Brain; Child; Child, Preschool; Developmental Disabilities; Dyskinesias; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Infant, Newborn; Intellectual Disability; Male; Pregnancy; Psychomotor Disorders; Reference Values; Regression, Psychology; Tetrahydrofolates	2008
Dietary treatment of homocystinuria. American journal of diseases of children (1960), 1967, Volume: 113, Issue:1 Topics: Amino Acid Metabolism, Inborn Errors; Betaine; Child, Preschool; Diet Therapy; Female; Folic Acid; Growth; Homocystinuria; Humans; Infant; Infant, Newborn; Intellectual Disability; Intelligence Tests; Male; Quaternary Ammonium Compounds	1967
Cytogenetic investigations in mentally retarded and normal males from 14 families with the fragile site at Xq28. Results of folic acid treatment on fra(X) expression. Human genetics, 1984, Volume: 66, Issue:2-3 Topics: Adolescent; Adult; Bromodeoxyuridine; Cells, Cultured; Child; Child, Preschool; Chromosome Fragile Sites; Chromosome Fragility; Female; Fibroblasts; Floxuridine; Folic Acid; Gene Expression Regulation; Genetic Markers; Humans; Infant; Intellectual Disability; Lymphocytes; Male; Methotrexate; Middle Aged; X Chromosome	1984
FUdR induction of the X chromosome fragile site: evidence for the mechanism of folic acid and thymidine inhibition. American journal of human genetics, 1981, Volume: 33, Issue:2 Topics: Cells, Cultured; DNA; Female; Floxuridine; Folic Acid; Humans; Intellectual Disability; Lymphocytes; Male; Sex Chromosome Aberrations; Sex Chromosomes; Thymidine; Thymidine Monophosphate; Thymidylate Synthase; X Chromosome	1981
[Mental retardation and fragile X chromosome. Clinical and cytogenetic study of 3 families]. Journal de genetique humaine, 1984, Volume: 32, Issue:3 Topics: Adult; Behavior; Child; Child, Preschool; Ear, External; Face; Female; Folic Acid; Fragile X Syndrome; Humans; Intellectual Disability; Male; Pedigree; Phenotype; Prenatal Diagnosis; Sex Chromosome Aberrations	1984
[Preliminary evaluation of the treatment with folic acid in 2 patients with sex-linked mental retardation and macroorchidism]. Revista medica de Chile, 1984, Volume: 112, Issue:5 Topics: Adult; Cytogenetics; Folic Acid; Fragile X Syndrome; Humans; Intellectual Disability; Male; Psychological Tests; Sex Chromosome Aberrations; Testis; Vitamin B 12	1984
[Fragile X chromosome syndrome: a chromosomal defect associated with mental retardation]. Revista medica de Chile, 1983, Volume: 111, Issue:6 Topics: Folic Acid; Fragile X Syndrome; Humans; Intellectual Disability; Sex Chromosome Aberrations; Trimethoprim; Vitamin B 12	1983
Folate metabolism in humans. American journal of medical genetics, 1984, Volume: 17, Issue:1 Topics: Amino Acids; Cells, Cultured; Chemical Phenomena; Chemistry; Culture Media; Folic Acid; Folic Acid Deficiency; Fragile X Syndrome; Histidine; Homocysteine; Humans; Intellectual Disability; Lymphocytes; Sex Chromosome Aberrations; Tetrahydrofolates	1984
Formiminoglutamic aciduria in a slightly retarded boy with chronic obstructive lung disease. Journal of inherited metabolic disease, 1981, Volume: 4, Issue:4 Topics: Child, Preschool; Chromatography, Thin Layer; Erythrocytes; Folic Acid; Formiminoglutamic Acid; Glutamate Formimidoyltransferase; Glutarates; Humans; Hydroxymethyl and Formyl Transferases; Intellectual Disability; Lung Diseases, Obstructive; Male; Transferases	1981
Treatment of fragile-X. Pediatrics, 1982, Volume: 69, Issue:5 Topics: Adolescent; Adult; Chromosome Fragility; Female; Folic Acid; Humans; Intellectual Disability; Leucovorin; Male; Sex Chromosome Aberrations; Vitamin B 12	1982
Heritable fragile sites on human chromosomes. VIII. Preliminary population cytogenetic data on the folic-acid-sensitive fragile sites. American journal of human genetics, 1982, Volume: 34, Issue:3 Topics: Adolescent; Adult; Child; Child, Preschool; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, 6-12 and X; Female; Folic Acid; Heterozygote; Humans; Infant, Newborn; Intellectual Disability; Karyotyping; Male; Sex Chromosomes; X Chromosome	1982
A case of formiminoglutamic aciduria. Clinical and biochemical studies. European journal of pediatrics, 1981, Volume: 136, Issue:3 Topics: Amino Acid Metabolism, Inborn Errors; Child, Preschool; Epilepsy; Folic Acid; Formiminoglutamic Acid; Glutarates; Histidine; Humans; Intellectual Disability; Male	1981
In vivo folic acid supplementation partially corrects in vitro methotrexate toxicity in patients with Down syndrome. British journal of haematology, 1995, Volume: 89, Issue:3 Topics: Adolescent; Adult; Cells, Cultured; Down Syndrome; Folic Acid; Humans; Intellectual Disability; Lymphocytes; Methotrexate; Mitotic Index	1995
Effect of folate metabolism on the psychopathology of adults with mental retardation and epilepsy. American journal of mental retardation : AJMR, 1994, Volume: 98, Issue:6 Topics: Activities of Daily Living; Adult; Aged; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intellectual Disability; Male; Middle Aged; Personality Assessment; Psychopathology; Substance-Related Disorders	1994
Segregation analysis of rare autosomal folate sensitive fragile sites. American journal of medical genetics, 1993, Apr-15, Volume: 46, Issue:2 Topics: Autistic Disorder; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human; Female; Folic Acid; Genes, Dominant; Heterozygote; Humans; Intellectual Disability; Male; Pedigree; Sex Ratio	1993
Methylenetetrahydrofolate reductase deficiency: importance of early diagnosis. Journal of child neurology, 2000, Volume: 15, Issue:8 Topics: Betaine; Child, Preschool; Diagnosis, Differential; Fatal Outcome; Fibroblasts; Folic Acid; Hematinics; Homocysteine; Homocystinuria; Homozygote; Humans; Infant; Intellectual Disability; Lipotropic Agents; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Treatment Outcome	2000
Reinterpretation of the haematological effects of anticonvulsant treatment. Lancet (London, England), 1978, Jun-24, Volume: 1, Issue:8078 Topics: Adult; Anemia, Hypochromic; Anemia, Macrocytic; Anemia, Megaloblastic; Anticonvulsants; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Humans; Intellectual Disability; Male; Middle Aged	1978
[Biochemical investigations and trisomy 21 (author's transl)]. Annales de genetique, 1979, Volume: 22, Issue:2 Topics: Down Syndrome; Folic Acid; Glyoxylates; Humans; Hydrogen Peroxide; Intellectual Disability; Oxalates; Superoxides; Thiamine; Tryptophan	1979
Plasma levels of folates, riboflavin, vitamin B6, and ascorbate in severely disturbed children. Journal of autism and developmental disorders, 1979, Volume: 9, Issue:1 Topics: Adolescent; Affective Symptoms; Ascorbic Acid; Autistic Disorder; Child; Child Behavior Disorders; Child, Preschool; Folic Acid; Humans; Intellectual Disability; Male; Orthomolecular Therapy; Psychotic Disorders; Pyridoxine; Riboflavin; Schizophrenia	1979
Fragile X chromosome related to mental retardation in males. JAMA, 1979, Oct-26, Volume: 242, Issue:17 Topics: Chromosome Deletion; Culture Media; Female; Fibroblasts; Folic Acid; Genetic Linkage; Humans; Intellectual Disability; Male; Sex Chromosome Aberrations; Sex Chromosomes; Sex Factors; X Chromosome	1979
Homocystinuria in New South Wales. Archives of disease in childhood, 1978, Volume: 53, Issue:3 Topics: Adolescent; Adult; Australia; Bone and Bones; Child; Child, Preschool; Ectopia Lentis; Female; Folic Acid; Homocystinuria; Humans; Infant; Intellectual Disability; Male; Pyridoxine; Thrombosis	1978
Red cell folate and macrocytosis during long-term anticonvulsant therapy in non-anaemic mentally. Retarded epileptics. The British journal of psychiatry : the journal of mental science, 1975, Volume: 126 Topics: Dose-Response Relationship, Drug; Epilepsy; Erythrocytes; Erythrocytes, Abnormal; Female; Folic Acid; Folic Acid Deficiency; Hematocrit; Humans; Intellectual Disability; Male; Phenobarbital; Time Factors; Yeast, Dried	1975
The neurologic aspects of transcobalamin II deficiency. British journal of haematology, 1992, Volume: 80, Issue:1 Topics: Central Nervous System Diseases; Folic Acid; Humans; Infant; Infant, Newborn; Intellectual Disability; Leucovorin; Nervous System Diseases; Time Factors; Transcobalamins; Vitamin B 12	1992
A new apparently folate sensitive fragile site, 5q35. Journal of medical genetics, 1990, Volume: 27, Issue:8 Topics: Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, Pair 5; Folic Acid; Humans; Intellectual Disability; Male	1990
Possible association of rare autosomal folate sensitive fragile sites and idiopathic mental retardation: a blind controlled population study. Clinical genetics, 1990, Volume: 38, Issue:4 Topics: Abnormalities, Multiple; Adult; Chromosome Aberrations; Chromosome Disorders; Chromosome Fragile Sites; Chromosome Fragility; Female; Folic Acid; Folic Acid Deficiency; Gene Expression Regulation; Gene Frequency; Genetic Carrier Screening; Genetic Counseling; Genetic Testing; Humans; Infant; Infant, Newborn; Intellectual Disability; Male; Phenotype	1990
[Questions about fragile X syndrome and mental retardation. Clinical and therapeutic aspects]. Annales medico-psychologiques, 1989, Volume: 147, Issue:10 Topics: Adolescent; Female; Folic Acid; Folic Acid Deficiency; Fragile X Syndrome; Heterozygote; Humans; Intellectual Disability; Male; Pedigree; Psychiatric Status Rating Scales; Psychological Tests; Sex Chromosome Aberrations	1989
Population cytogenetics of folate-sensitive fragile sites. II. Autosomal rare fragile sites. Human genetics, 1989, Volume: 82, Issue:1 Topics: Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosome Mapping; Folic Acid; Gene Frequency; Genetics, Population; Humans; Intellectual Disability; Pedigree; Translocation, Genetic	1989
Expression of the autosomal folate-sensitive fragile sites in ten kindreds with Martin-Bell syndrome. Annales de genetique, 1986, Volume: 29, Issue:1 Topics: Chromosome Fragile Sites; Chromosome Fragility; Female; Folic Acid; Fragile X Syndrome; Humans; Intellectual Disability; Male; Phenotype; Sex Chromosome Aberrations	1986
False negative results in patients with fra(X) (q) mental retardation taking oral vitamin supplements. The New England journal of medicine, 1987, Apr-23, Volume: 316, Issue:17 Topics: Chromosome Fragility; False Negative Reactions; Folic Acid; Humans; Intellectual Disability; Male	1987
Fragile 19p13 in a family with mental illness. Clinical genetics, 1987, Volume: 31, Issue:1 Topics: Adult; Chromosome Aberrations; Chromosome Disorders; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, 19-20; Diseases in Twins; Folic Acid; Humans; Intellectual Disability; Male; Mental Disorders; Pedigree	1987
Population cytogenetics of autosomal fragile sites. Clinical genetics, 1987, Volume: 31, Issue:1 Topics: Cells, Cultured; Chromosome Fragile Sites; Chromosome Fragility; Female; Folic Acid; Humans; Intellectual Disability; Male	1987
Folate metabolism and problem behaviour in mentally handicapped epileptics. Journal of mental deficiency research, 1987, Volume: 31 ( Pt 2) Topics: Adolescent; Adult; Aged; Epilepsy; Female; Folic Acid; Humans; Intellectual Disability; Male; Mental Disorders; Middle Aged; Phenytoin; Vitamin B 12	1987
Population cytogenetics of autosomal fragile sites. Clinical genetics, 1986, Volume: 29, Issue:2 Topics: Chromosome Fragile Sites; Chromosome Fragility; Folic Acid; Intellectual Disability	1986
Congenital folate malabsorption. European journal of pediatrics, 1985, Volume: 143, Issue:4 Topics: Anemia, Macrocytic; Anemia, Megaloblastic; Biological Transport; Blood-Brain Barrier; Brain Diseases; Calcinosis; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Infections; Intellectual Disability; Intestinal Absorption; Methionine; Seizures	1985
Pyrimethamine poisoning. British medical journal, 1973, Oct-20, Volume: 4, Issue:5885 Topics: Anemia, Macrocytic; Ataxia; Blindness; Central Nervous System; Child, Preschool; Deafness; Female; Fever; Folic Acid; Folic Acid Antagonists; Humans; Infant; Intellectual Disability; Leucovorin; Male; Pyrimethamine	1973
Increase in serum folate following on oral histidine load. The Tohoku journal of experimental medicine, 1972, Volume: 108, Issue:3 Topics: Administration, Oral; Adolescent; Adult; Child; Female; FIGLU Test; Folic Acid; Formamides; Histidine; Humans; Intellectual Disability; Male; Metabolism, Inborn Errors; Skin; Syphilis Serodiagnosis; Syphilis, Congenital; Transferases	1972
Gaucher's disease: neurologic disorder in adult siblings. Annals of internal medicine, 1973, Volume: 78, Issue:6 Topics: Adult; Alkaline Phosphatase; Bone Marrow; Cerebrosides; Chromatography, Thin Layer; Electrocardiography; Female; Folic Acid; Gaucher Disease; Glucose; Glycolipids; Glycoside Hydrolases; Humans; Intellectual Disability; Leukocytes; Liver; Liver Function Tests; Male; Middle Aged; Nervous System Diseases; Neurologic Examination; Reflex, Pupillary; Seizures; Spleen; Vision Disorders	1973
Effect of diphenylhydantoin therapy on folate metabolism of mentally retarded epileptics. The Tohoku journal of experimental medicine, 1973, Volume: 110, Issue:1 Topics: Adolescent; Adult; Anticonvulsants; Azo Compounds; Child; Epilepsy; Female; FIGLU Test; Folic Acid; Glutarates; Histidine; Humans; Intellectual Disability; Male; Neutrophils; Phenytoin; Vitamin B 12	1973
[Folic acid sensitive, non-megalocytic erythroblastopenia in an epileptic]. Acta haematologica, 1968, Volume: 39, Issue:3 Topics: Adult; Anemia, Aplastic; Anticonvulsants; Blood Cell Count; Blood Volume Determination; Bone Marrow Examination; Edema; Eosinophilia; Epilepsy; Exanthema; Female; Folic Acid; Hemoglobinometry; Humans; Hydantoins; Intellectual Disability; Leukopenia; Purpura	1968
Isolated defect of folic acid absorption associated with mental retardation and cerebral calcification. Blood, 1969, Volume: 34, Issue:4 Topics: Adolescent; Basal Ganglia; Biological Transport; Bone Marrow Examination; Brain Diseases; Calcinosis; Chromosome Aberrations; Epilepsy, Absence; Epilepsy, Tonic-Clonic; Female; Folic Acid; Folic Acid Deficiency; Humans; Intellectual Disability; Intestinal Absorption; Malabsorption Syndromes; Radiography; Skull; Stomatitis; Tritium	1969
[Megaloblastic anemia in children]. Nordisk medicin, 1971, Volume: 86, Issue:49 Topics: Adolescent; Anemia, Macrocytic; Blood Transfusion; Child; Female; Folic Acid; Humans; Intellectual Disability; Phenytoin; Vitamin B 12	1971
Anticonvulsant drugs and folic acid in young mentally retarded epileptic patients. A study of serum folate, fit frequency and I.Q. Epilepsia, 1971, Volume: 12, Issue:3 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Epilepsy; Ethosuximide; Female; Folic Acid; Humans; Intellectual Disability; Intelligence Tests; Male; Phenobarbital; Phenytoin; Primidone; Prognosis	1971
Megaloblastic anemia and mental retardation associated with hyperfolic-acidemia: probably due to N5 methyltetrahydrofolate transferase deficiency. The Tohoku journal of experimental medicine, 1967, Volume: 93, Issue:1 Topics: Adult; Aged; Anemia, Macrocytic; Biological Assay; Blood Proteins; Bone Marrow Examination; Cerebral Ventriculography; Child; Child, Preschool; Dietary Fats; Electroencephalography; Erythrocytes; Female; FIGLU Test; Folic Acid; Humans; Hydrolases; Infant; Intellectual Disability; Intestinal Absorption; Liver; Liver Function Tests; Male; Metabolism, Inborn Errors; Middle Aged; Oxidoreductases; Transferases; Vitamin B 12; Xylose	1967
Congenital defects in folate utilization. The American journal of medicine, 1970, Volume: 48, Issue:5 Topics: Anemia, Macrocytic; Animals; Brain Damage, Chronic; Carbon Dioxide; Deficiency Diseases; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant; Intellectual Disability; Male; Metabolism, Inborn Errors; Transferases	1970
Mental deterioration in epilepsy due to folate deficiency. British medical journal, 1970, Jun-27, Volume: 2, Issue:5712 Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intellectual Disability; Male; Vitamin B 12	1970
The influence of adenine on the clinical features and purine metabolism in the Lesch-Nyhan syndrome. Acta paediatrica Scandinavica, 1970, Volume: 59, Issue:3 Topics: Adenine; Allopurinol; Athetosis; Bone Marrow; Carbon Isotopes; Child; Child, Preschool; Chorea; Compulsive Behavior; Diet Therapy; Erythrocytes; Folic Acid; Glycine; Humans; Intellectual Disability; Male; Metabolism, Inborn Errors; Movement Disorders; Purines; Self Mutilation; Transferases; Uric Acid; Vitamin B 12	1970
Folic acid and mental illness. Southern medical journal, 1970, Volume: 63, Issue:5 Topics: Age Factors; Aged; Anticonvulsants; Barbiturates; Contraceptives, Oral; Female; Folic Acid; Humans; Intellectual Disability; Mental Disorders; Metabolism, Inborn Errors; Postpartum Period; Pregnancy	1970
Folic-acid deficiency in psychiatric patients. The Medical journal of Australia, 1970, Jun-13, Volume: 1, Issue:24 Topics: Aged; Alcoholism; Australia; Blood Cell Count; Blood Sedimentation; Female; Folic Acid; Folic Acid Deficiency; Hematocrit; Hemoglobinometry; Humans; Intellectual Disability; Male; Mental Disorders; Middle Aged; Substance-Related Disorders; Vitamin B 12	1970
[Treatment of children with memory disorders with orotic and folic acids and vitamin B12]. Sovetskaia meditsina, 1970, Volume: 33, Issue:7 Topics: Child; Electroencephalography; Folic Acid; Galvanic Skin Response; Humans; Intellectual Disability; Memory Disorders; Orotic Acid; Personality Disorders; Vitamin B 12	1970
The urinary excretion of aminoimidazolecarboxamide in the Lesch-Nyhan syndrome. Pediatrics, 1970, Volume: 46, Issue:4 Topics: Adolescent; Athetosis; Child; Child, Preschool; Chorea; Compulsive Behavior; Female; Folic Acid; Humans; Imidazoles; Intellectual Disability; Male; Purine-Pyrimidine Metabolism, Inborn Errors; Self Mutilation; Uric Acid	1970
Homocystinuria. Report of two cases in siblings. Indian journal of pediatrics, 1970, Volume: 37, Issue:269 Topics: Child; Cystine; Diet Therapy; Female; Folic Acid; Homocystinuria; Humans; Intellectual Disability; Lens, Crystalline; Male; Pedigree; Pyridoxine	1970
[Congenital absence of the stomach]. Annales de pediatrie, 1971, May-02, Volume: 18, Issue:5 Topics: Body Weight; Brain Diseases; Child, Preschool; Electroencephalography; Folic Acid; Humans; Hypoglycemia; Infant; Infant, Newborn; Infant, Premature; Intellectual Disability; Malabsorption Syndromes; Male; Radiography; Stomach; Vitamin B 12	1971
Inborn errors in folate metabolism--a cause of mental retardation? Annals of internal medicine, 1968, Volume: 68, Issue:4 Topics: Adult; Biological Assay; Diet Therapy; Female; FIGLU Test; Folic Acid; Folic Acid Deficiency; Humans; Hydrolases; Infant, Newborn; Intellectual Disability; Lactobacillus; Male; Metabolism, Inborn Errors; Pregnancy; Tetrahydrofolate Dehydrogenase; Transferases; Vitamin B 12 Deficiency	1968
Mental effects of anticonvulsants, and folic acid metabolism. Brain : a journal of neurology, 1968, Volume: 91, Issue:2 Topics: Age Factors; Anemia, Macrocytic; Anticonvulsants; Brain; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Intellectual Disability; Male; Mental Disorders; Peripheral Nerves; Phenobarbital; Phenytoin; Primidone; Psychotic Disorders; Sex Factors; Spinal Cord; Vitamin B 12	1968
Formiminotransferase-deficiency syndrome: a new inborn error of folic acid metabolism. Annales paediatrici. International review of pediatrics, 1965, Volume: 205, Issue:1 Topics: Bone Marrow Cells; Chromosomes; Female; FIGLU Test; Folic Acid; Growth; Humans; Infant; Intellectual Disability; Liver; Liver Function Tests; Metabolism, Inborn Errors; Tetrahydrofolate Dehydrogenase; Transferases	1965
Mental retardation with hyperfolic-acidemia not associated with formiminoglutamic-acciduria: cyclohydrolase deficiency syndrome. The Tohoku journal of experimental medicine, 1966, Apr-25, Volume: 88, Issue:4 Topics: Child, Preschool; Erythrocytes; Female; FIGLU Test; Folic Acid; Humans; Infant; Intellectual Disability; Liver; Male; Metabolism, Inborn Errors; Transferases	1966
Folate metabolism in homocystinuria. Irish journal of medical science, 1966, Volume: 6, Issue:491 Topics: Child; Cystinuria; Female; Folic Acid; Humans; Intellectual Disability; Male; Metabolism, Inborn Errors	1966