Page last updated: 2024-08-17

folic acid and Harelip

folic acid has been researched along with Harelip in 138 studies

Research

Studies (138)

Timeframe	Studies, this research(%)	All Research%
pre-1990	5 (3.62)	18.7374
1990's	13 (9.42)	18.2507
2000's	48 (34.78)	29.6817
2010's	58 (42.03)	24.3611
2020's	14 (10.14)	2.80

Authors

Authors	Studies
Jin, L; Liu, C; Meng, W; Shang, X; Wang, D; Zhang, J	1
Clark, P; Domínguez, JN; Lavielle-Sotomayor, P; López-Rodríguez, L; Pérez-Días, ME; Pérez-González, A; Vega-Hernández, D	1
de Andrade, RS; de Barros, LM; Martelli Júnior, H; Martelli, DRB; Oliveira, FES	1
Nguku, P; Nwafor, MI; Nwokoro, UU; Obi, IF; Ossai, OP	1
Almasri, IA; Audeh, M; Darjazini Nahas, L; Hmadieh, M; Martini, N; Yousfan, A	1
Abebaw, E; Essa, E; Lake, A; Shitie, D; Taye, A; Tsehay, B	1
Zablow, SB	1
Mendonca, VJ	1
Fu, S; Jia, X; Li, Q; Saleem, K; Sun, W; Xu, L; Zaib, T	1
Jin, L; Li, Z; Liu, J; Pi, X; Qiao, Y; Ren, A; Wang, C; Wang, L	1
Johnson, CY; Little, J; Mossey, P; Sikora, L; Sinnathamby, V; Yu, Y; Zhou, Y	1
Alois, CI; Ruotolo, RA	1
Balakrishnan, K; Kuppuswamy, R; Kurpad, AV; Molloy, AM; Mossey, PA; Munger, RG; Murthy, J; Sambandam, S; Thangavel, G; Ueland, PM	1
Dai, L; Deng, C; Liu, H; Ran, L; Ren, Z; Xu, W; Yi, L; Zhang, G; Zhao, S; Zhao, Z; Zhou, T	1
Inostroza, V; Leiva, N; Pantoja, R; Pardo, R; Recabarren, AS; Salamanca, C; Suazo, J	1
Bortolus, R; Buzzi, T; Montagnoli, C; Santoro, CB	1
Cifuentes, L; Millacura, N; Pardo, R; Suazo, J	1
Bharti, P; Bonanthaya, K; Datta, V; Doyle, P; Gosla, SR; Gudlavalleti, VSM; Kinra, S; Kolli, SR; Neogi, SB; Ness, A; Pallepogula, DR; Pant, H; Singh, S	1
Andreasi, RB; Autelitano, L; Khan, MFJ; Little, J; Lombardo, I; Mossey, PA; Rubini, M; Steegers-Theunissen, RP	1
Cao, RY; Du, PG; Liu, DW; Qu, WD; Sun, C; Xu, DP	1
Amini, E; Ghassemi, A; Jafari, M; Jamilian, A; Khosravi, S; Neshandar, M; Sarkarat, F	1
Beaty, TH; Li, J; Liu, DJ; Schwender, H; Shi, B; Wang, H; Wang, MY; Wang, P; Wang, ZQ; Wu, T; Yuan, Y; Zhou, ZB; Zhu, HP	1
Ronco, AM; Tovani-Palone, MR	1
Abtahi, M; Jahanbin, A; Miri, HH; Shadkam, E; Shirazi, AS	1
Asrani, K; Gonseth, S; Marini, NJ; Rine, J; Roy, R; Segal, MR; Shaw, GM; Wiemels, J	1
Martín-Del-Campo, M; Rojo, L; Rosales-Ibañez, R	1
Han, X; Hirofuji, Y; Masuda, K; Sato, H; Sun, X; Zhang, Y	1
Carmichael, SL; Lammer, EJ; Perloff, S; Shaw, GM; Shaw, NM; Yang, W; Zhu, H	1
Brender, JD; Canfield, MA; Griesenbeck, JS; Huber, JC; Langlois, PH; Romitti, PA; Sharkey, JR; Shinde, MU; Suarez, L; Vuong, AM; Weyer, PJ; Zheng, Q	1
Röckl, T; Scheller, C; Scheller, K; Schubert, J	1
Affonso, CM; Chakraborty, H; Félix, TM; Gewehr, EV; Goco, N; Lins, L; Moore, J; Murray, JC; Queirós, FC; Vila-Nova, C; Wehby, GL	1
Butali, A; Chevrier, C; Cordier, S; Jugessur, A; Little, J; Mossey, PA; Oladugba, B; Steegers-Theunissen, R	1
Domosławska, A; Janowski, T; Jurczak, A	1
Beaty, TH; Cao, WH; Huang, SZ; Liang, KY; Shi, B; Wang, H; Wang, P; Wu, T; Wu-chou, YH; Ye, XQ	1
Bakker, MK; de Walle, HE; Goorhuis-Brouwer, SM; Rozendaal, AM; te Meerman, GJ; van der Biezen, JJ; van Essen, AJ; Vermeij-Keers, C	1
Chowchuen, B; Derouen, T; Godfrey, K; McKinney, CM; Pisek, A; Pitiphat, W	1
Kappen, C	1
Czeizel, AE	1
Alcántara-Ortigoza, MA; Estandia-Ortega, B; González-Del Angel, A; Reyna-Fabian, ME; Velázquez-Aragón, JA; Villagómez-Martínez, S	1
Bieski, I; Damazo, AS; Espinosa, M; Feguri, A; Figueiredo, N; Figueiredo, RF; Mello, R	1
Jiang, C; Li, H; Song, T; Wang, Y; Wu, D; Yin, N; Zhao, Z	1
Almeida, Md; Bezerra, JF; Cardoso, ML; Fajardo, CM; Hirata, MH; Hirata, RD; Lima-Neto, LG; Luchessi, AD; Neto, FP; Oliveira, GH; Oliveira, SR; Rezende, AA; Silbiger, VN; Soares, CD; Ururahy, MA	1
Chen, EJ; Hou, W; Hu, Y; Jin, LL; Liu, XH	1
Ju, Q; Li, YQ; Liu, YP; Peng, X; Wang, H; Wang, Q; Wu, QR; Xia, YJ; Xu, LC; Xu, LF; Yu, HM; Zhang, JP; Zhang, MR; Zhou, JL; Zhou, XL	1
Bjørge, T; Gildestad, T; Haaland, ØA; Klungsøyr, K; Nilsen, RM; Vollset, SE; Øyen, N	1
Carmichael, SL; Shaw, GM; Yang, W	1
Blanco, R; Colombo, A; Pardo, R; Suazo, J	1
Asrani, K; Lammer, EJ; Marini, NJ; Rine, J; Shaw, GM; Witte, JS; Yang, W	1
Broussain, V; Cavada, G; Hasbún, A; Lagos, C; Paulos, A; Pino, P	1
Johnson, CY; Little, J	1
Cardy, A; Clayton-Smith, J; Fitzpatrick, D; Fryer, AE; Gilmour, M; Little, J; Mossey, PA	1
Cardy, A; Clayton-Smith, J; Duthie, SJ; Fitzpatrick, D; Fryer, AE; Gilmour, M; Hill, A; Little, J; Molloy, AM; Mossey, PA; Scott, JM	1
Bliek, BJ; Blok, LJ; de Klein, A; Lindemans, J; Oostra, BA; Santegoets, LA; Steegers, EA; Steegers-Theunissen, RP	1
Brody, LC; Conley, MR; Cox, C; Doyle, A; Earley, M; Kirke, PN; Lynn, EC; McKiernan, E; Mills, JL; Molloy, AM; Orr, DJ; Pangilinan, F; Parle-McDermott, A; Scott, JM; Troendle, JF	1
Castilla, EE; Cooper, ME; Marazita, ML; Orioli, IM; Vieira, AR	1
Boyles, AL; Christensen, K; Drevon, CA; Fredriksen, A; Gjessing, HK; Johansen, AM; Jugessur, A; Lie, RT; Meyer, K; Murray, JC; Shi, M; Taylor, JA; Trung, TN; Ueland, PM; Vollset, SE; Weinberg, CR; Wilcox, AJ	1
Blom, H; Carmichael, SL; Finnell, RH; Shaw, GM; Ueland, PM; Vollset, SE; Yang, W	1
Dziegelewska, M; Hozyasz, KK; Jagodzinski, PP; Mostowska, A; Wojcicki, P	1
Steegers, EA; Steegers-Theunissen, RP; Uitterlinden, AG; van Meurs, J; van Rooij, IA; Vujkovic, M; Yazdanpanah, N	1
Arakeri, G; Arali, V; Brennan, PA	1
Murray, JC; Wehby, GL	1
Erickson, RP	1
Bufalino, A; Coletta, RD; Martelli-Júnior, H; Nascimento de Aquino, S; Oliveira Swerts, MS; Ribeiro Paranaíba, LM	1
Jin, Y; Liang, Q; Long, H; Zhong, C	1
Blanton, SH; Burt, A; Chiquet, BT; Hecht, JT; Henry, R; Mulliken, JB; Stal, S	1
Blanton, SH; Finnell, RH; Hecht, JT; Henry, RR; Mulliken, JB; Stal, S; Yuan, Q	1
Carey, JC; Cutler, R; Feldkamp, ML; Johnston, KE; Munger, RG; Murtaugh, MA; Pfister, R; Tamura, T	1
Bhaskar, LV; Murthy, J; Venkatesh Babu, G	1
Chen, CH; Jia, ZL; Shi, B; Shi, JY; Wu, J; Xu, X	1
Ballard, JL; Boyles, AL; Cabrera, RM; Finnell, RH; Gorman, EB; Lie, RT; McConnaughey, DR; Wilcox, AJ	1
Bartels, E; Beckers, GM; Boemers, TM; Bökenkamp, A; Boyadjiev, SA; Detlefsen, B; Draaken, M; Ebert, AK; Gambhir, L; Gearhart, JP; Gobet, R; Jaureguizar, E; Jenetzky, E; Kajbafzadeh, AM; Lakshmanan, Y; Ludwig, M; Müller, M; Nöthen, MM; Reutter, H; Rogenhofer, S; Rösch, WH; Schröder, A; Stein, R; Utsch, B; Vogt, H; Zwink, N	1
Berry, RJ; Chao, A; Erickson, JD; Hao, L; Li, S; Li, Z; Liu, Y; Moore, CA; Zhu, J	1
Gjessing, HK; Jugessur, A; Lie, RT; Lunde, A; Murray, JC; Nguyen, TT; Skare, O; Wilcox, AJ	1
Houston, M	1
Kelly, D; O'Dowd, T; Reulbach, U	1
Alcántara-Ortigoza, MA; Cruz-Fuentes, C; Estandia-Ortega, B; González-del Angel, A; Reyna-Fabián, ME; Velázquez-Aragón, JA; Villagómez, S	1
Chakraborty, H; Felix, T; Goco, N; Guimaraes, CV; Hartwell, T; Javois, L; Litavecz, S; Moretti-Ferreira, D; Murray, JC; Padovani, C; Pereira, R; Queiros, F; Richieri-Costa, A; Wehby, GL	1
Iglesias-Linares, A; Mendoza-Mendoza, A; Molina-Solana, R; Solano-Reina, E; Yáñez-Vico, RM	1
Bell, JC; Bower, C; Nassar, N; Raynes-Greenow, C; Roberts, CL; Turner, RM	1
Chakraborty, H; Félix, TM; Goco, N; Moretti-Ferreira, D; Murray, JC; Padovani, C; Pereira, R; Richieri-Costa, A; Souza, J; Wehby, GL	1
Braune, A; Grunert, RR; Krause, HR; Schloot, W; Schnackenberg, E	1
Beaty, TH; Zeiger, JS	1
Goorhuis-Brouwer, SM; Kluijtmans, LA; Kuijpers-Jagtman, AM; Ocké, MC; Steegers-Theunissen, RP; van der Biezen, JJ; van Rooij, IA; Vermeij-Keers, C; Zielhuis, GA	1
Abyholm, FE; Drevon, CA; Jugessur, A; Lie, RT; Murray, JC; Taylor, JA; Ulvik, A; Vindenes, HA; Wilcox, AJ	1
BERNHARD, WG; PECK, GC; PEER, LA; STREAN, LP; WALKER, JC	1
Yerby, MS	1
Finnell, RH; Lammer, EJ; Shaw, GM; Yang, W; Zhu, H	1
Källén, B	1
Blom, HJ; Merkus, HM; Steegers-Theunissen, RP; Swinkels, DW; van Rooij, IA	1
Abyholm, FE; Jugessur, A; Lie, RT; Murray, JC; Saugstad, OD; Taylor, JA; Vindenes, HA; Wilcox, AJ	1
Cole, DE; Meier, C; Ray, JG; Vermeulen, MJ; Wyatt, PR	1
Krapels, IP; Kuijpers-Jagtman, AM; Ocké, MC; Steegers-Theunissen, RP; van Cleef, BA; van Rooij, IA	1
Brussel, W; Krapels, IP; Rooij, IA; Spauwen, PH; Steegers-Theunissen, RP; Wevers, RA; Zielhuis, GA	1
Corcoran, C; Daack-Hirsch, S; Munger, RG; Nepomuceno, B; Sauberlich, HE; Solon, FS	1
Merkus, HM; Ocké, MC; Steegers-Theunissen, RP; Straatman, H; van Rooij, IA; Zielhuis, GA	1
Finnell, RH; Iovannisci, DM; Lammer, EJ; Shaw, GM	1
Bille, C; Christensen, K; Knudsen, LB	1
Finnell, RH; Li, Z; Pei, L; Ren, A; Zhu, H; Zhu, J	1
Czeizel, AE; Métneki, J; Puhó, E	1
Bahuau, M; Cordier, S; Francannet, C; Herman, C; Monfort, C; Nelva, A; Robert-Gnansia, E; Rouget, F	1
Finnell, RH; Hao, L; Li, S; Li, Z; Liu, J; Pei, L; Ren, A; Zhu, H; Zhu, J	1
Baciliero, U; Carinci, F; Carinci, P; Martinelli, M; Morselli, PG; Padula, E; Palmieri, A; Pezzetti, F; Scapoli, L	1
Bliek, JB; Rothenberg, SP; Steegers-Theunissen, RP	1
de Jong-van den Berg, LT; Krapels, IP; Kuijpers-Jagtman, AM; Steegers-Theunissen, RP; van der Molen, AB; Vroom, F; Zielhuis, GA	1
Aubert, MM; Boyd, RL; Ellerhorst, T; Mosby, T; Oh, H; Poulton, D; Tolar, M; Tolarová, MM	1
Badovinac, RL; Hayes, C; Kelsey, KT; Werler, MM; Williams, PL	1
Honein, MA; Xing, J; Yazdy, MM	1
Bahuau, M; Chevrier, C; Cordier, S; Finnell, RH; Francannet, C; Herman, C; Nelva, A; Perret, C; Robert-Gnansia, E; Zhu, H	1
Abyholm, F; Drevon, CA; Lie, RT; McConnaughey, DR; Solvoll, K; Taylor, J; Vindenes, H; Vollset, SE; Wilcox, AJ	1
Chen, W; Fu, MH; Huang, MZ; Wu, XY	1
Correa, A; Honein, MA; Rasmussen, SA; Reefhuis, J; Romitti, PA; Sun, L	1
Eichholzer, M	1
Boyles, AL; Drevon, CA; Fredriksen, A; Lie, RT; Meyer, K; Taylor, JA; Ueland, PM; Vollset, SE; Wilcox, AJ	1
Hustad, S; Ueland, PM	1
Tolarova, M	1
Lammer, EJ; O'Malley, CD; Shaw, GM; Tolarova, MM; Wasserman, CR	1
Harris, J; Tolarova, M	1
Hayes, C; Mitchell, AA; Werler, MM; Willett, WC	1
Czeizel, AE; Hirschberg, J	1
Lammer, EJ; Murray, JC; Shaw, GM; Wasserman, CR	1
Hartridge, T; Illing, HM; Sandy, JR	1
Burke, H; Conley, MR; Kirke, PN; Lee, YJ; Mayne, PD; Mills, JL; Molloy, AM; Scott, JM; Weir, DG	1
Mills, JL	1
Blom, HJ; Eskes, TK; Hamel, BC; Kuijpers-Jagtman, AM; Spauwen, PH; Steegers, EA; Steegers-Theunissen, RP; Thomas, CM; Wong, WY	1
Akiyama, Y; Kawai, T; Nagatsu, Y; Natsume, N	1
Czeizel, AE; Sárközi, A; Tímár, L	1
Hernández-Díaz, S; Mitchell, AA; Walker, AM; Werler, MM	1
Freitas, JA; Loffredo, LC; Mossey, PA; Souza, JM	1
Itikala, PR; Liu, Y; Moore, CA; Mulinare, J; Watkins, ML	1
Spritz, RA	1
Malcolm, S; Prescott, NJ	1
Briggs, RM	1
Aderet, NB; Biale, Y; Lewenthal, H	1
Czeizel, AE; Dudás, I	1
Andermann, E; Dansky, LV; Rosenblatt, DS	1
Baumgardner, R; Blake, DA; Mellits, ED; Niebyl, JR; Rocco, LE	1

Reviews

24 review(s) available for folic acid and Harelip

Article	Year
SNPs in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palate, a meta-analysis. Bioscience reports, 2020, 03-27, Volume: 40, Issue:3 Topics: Asian People; Brain; Case-Control Studies; China; Cleft Lip; Cleft Palate; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Homocystinuria; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Polymorphism, Single Nucleotide; Psychotic Disorders; Risk Factors	2020
Folate intake, markers of folate status and oral clefts: An updated set of systematic reviews and meta-analyses. Birth defects research, 2020, Volume: 112, Issue:19 Topics: Biomarkers; Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Mouth Abnormalities; Pregnancy	2020
Maternal periconceptional nutrition matters. A scoping review of the current literature. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2022, Volume: 35, Issue:25 Topics: Cleft Lip; Cleft Palate; Diet, Mediterranean; Female; Folic Acid; Humans; Infant, Newborn; Preconception Care; Pregnancy; Premature Birth	2022
Effects of folic acid fortification on orofacial clefts prevalence: a meta-analysis. Public health nutrition, 2017, Volume: 20, Issue:12 Topics: Cleft Lip; Cleft Palate; Folic Acid; Food, Fortified; Humans; Prevalence	2017
Maternal Folic Acid Supplementation and the Risk of Oral Clefts in Offspring. The Journal of craniofacial surgery, 2018, Volume: 29, Issue:6 Topics: Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Infant, Newborn; Maternal Exposure; Pregnancy; Risk Factors; Vitamin B Complex	2018
Biomaterials for Cleft Lip and Palate Regeneration. International journal of molecular sciences, 2019, May-02, Volume: 20, Issue:9 Topics: Animals; Biocompatible Materials; Cleft Lip; Cleft Palate; Folic Acid; Humans; Intercellular Signaling Peptides and Proteins; Osteogenesis; Regenerative Medicine; Stem Cell Transplantation; Tissue Engineering	2019
Folic acid supplementation use and the MTHFR C677T polymorphism in orofacial clefts etiology: An individual participant data pooled-analysis. Birth defects research. Part A, Clinical and molecular teratology, 2013, Volume: 97, Issue:8 Topics: Adult; Brain; Case-Control Studies; Cleft Lip; Cleft Palate; Dietary Supplements; Ethanol; Female; Folic Acid; Humans; Male; Maternal Exposure; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors; Smoking	2013
Modeling anterior development in mice: diet as modulator of risk for neural tube defects. American journal of medical genetics. Part C, Seminars in medical genetics, 2013, Volume: 163C, Issue:4 Topics: Anencephaly; Animals; Cleft Lip; Cleft Palate; Diabetes, Gestational; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Gene-Environment Interaction; Humans; Maternal Nutritional Physiological Phenomena; Mice; Morphogenesis; Neural Tube Defects; Pregnancy	2013
Lack of Association Between MTHFR, MTR, MTRR, and TCN2 Genes and Nonsyndromic CL±P in a Chinese Population: Case-Control Study and Meta-Analysis. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2015, Volume: 52, Issue:5 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alleles; Case-Control Studies; China; Cleft Lip; Cleft Palate; Ferredoxin-NADP Reductase; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Haplotypes; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Transcobalamins	2015
Maternal biomarkers of methylation status and non-syndromic orofacial cleft risk: a meta-analysis. International journal of oral and maxillofacial surgery, 2016, Volume: 45, Issue:11 Topics: Biomarkers; Cleft Lip; Cleft Palate; Female; Folic Acid; Homocysteine; Humans; Methylation; Pregnancy; Vitamin B 12	2016
Folate intake, markers of folate status and oral clefts: is the evidence converging? International journal of epidemiology, 2008, Volume: 37, Issue:5 Topics: Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Mouth Abnormalities; Odds Ratio; Polymorphism, Genetic; Pregnancy; Vitamin B Complex; Vitamins	2008
Folic acid and orofacial clefts: a review of the evidence. Oral diseases, 2010, Volume: 16, Issue:1 Topics: Cleft Lip; Cleft Palate; Clinical Trials as Topic; Folic Acid; Gene Expression Regulation, Developmental; Humans; Neural Tube Defects; Vitamin B Complex	2010
Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid. The Journal of craniofacial surgery, 2010, Volume: 21, Issue:5 Topics: 6-Aminonicotinamide; Animals; Arylamine N-Acetyltransferase; Cleft Lip; Cleft Palate; Disease Models, Animal; DNA Methylation; Folic Acid; Genetic Predisposition to Disease; Hydrocortisone; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenytoin; Polymerase Chain Reaction; Risk Factors	2010
Polymorphisms in genes involved in folate metabolism and orofacial clefts. Archives of oral biology, 2011, Volume: 56, Issue:8 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Betaine-Homocysteine S-Methyltransferase; Cleft Lip; Cleft Palate; Cystathionine beta-Synthase; Ferredoxin-NADP Reductase; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Membrane Transport Proteins; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic	2011
Current concepts on the effect of environmental factors on cleft lip and palate. International journal of oral and maxillofacial surgery, 2013, Volume: 42, Issue:2 Topics: Alcohol Drinking; Cleft Lip; Cleft Palate; Confidence Intervals; Environmental Exposure; Female; Fever; Folic Acid; Humans; Infant, Newborn; Life Change Events; Likelihood Functions; Linear Models; Nicotiana; Obesity; Odds Ratio; Pregnancy; Pregnancy Complications; Publication Bias; Zinc	2013
Is there a relationship between risk factors for oral clefts? Teratology, 2002, Volume: 66, Issue:5 Topics: Birth Order; Cleft Lip; Cleft Palate; Confounding Factors, Epidemiologic; Environmental Exposure; Female; Folic Acid; Homocysteine; Humans; Infant, Newborn; Maternal-Fetal Exchange; Odds Ratio; Pregnancy; Risk Factors; Smoking; Socioeconomic Factors	2002
Management issues for women with epilepsy: neural tube defects and folic acid supplementation. Neurology, 2003, Sep-01, Volume: 61, Issue:6 Suppl 2 Topics: Adult; Animals; Anticonvulsants; Carbamazepine; Cleft Lip; Cleft Palate; Epilepsy; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant, Newborn; Neural Tube Defects; Pregnancy; Pregnancy Complications; Spinal Dysraphism; Valproic Acid	2003
Folic acid-containing supplement consumption during pregnancy and risk for oral clefts: a meta-analysis. Birth defects research. Part A, Clinical and molecular teratology, 2007, Volume: 79, Issue:1 Topics: Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Infant, Newborn; Pregnancy; Risk Factors	2007
[Is periconceptional use of folic acid associated with a reduced risk of cleft lip with or without cleft palate?]. Praxis, 2007, Oct-03, Volume: 96, Issue:40 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Cohort Studies; Female; Folic Acid; Humans; Infant, Newborn; Preconception Care; Pregnancy; Prenatal Care; Vitamins	2007
The role of folic acid in oral clefting. British journal of orthodontics, 1999, Volume: 26, Issue:2 Topics: Cleft Lip; Cleft Palate; Dietary Supplements; Environment; Female; Fetus; Folic Acid; Humans; Maxillofacial Abnormalities; Neural Tube Defects; Pregnancy; Protective Agents	1999
Folate and oral clefts: where do we go from here? New directions in oral clefts research. Teratology, 1999, Volume: 60, Issue:5 Topics: Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Variation; Homocysteine; Humans; Infant, Newborn; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Pregnancy	1999
The genetics and epigenetics of orofacial clefts. Current opinion in pediatrics, 2001, Volume: 13, Issue:6 Topics: Cleft Lip; Cleft Palate; Folic Acid; Genetic Linkage; Homeodomain Proteins; Humans; MSX1 Transcription Factor; Mutation; Syndrome; T-Box Domain Proteins; Transcription Factors	2001
Folate and the face: evaluating the evidence for the influence of folate genes on craniofacial development. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2002, Volume: 39, Issue:3 Topics: Cleft Lip; Cleft Palate; Dietary Supplements; Disease Susceptibility; Environment; Face; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Genetic Variation; Humans; Phenotype; Pregnancy	2002
Mechanisms of teratogenesis: folic acid and antiepileptic therapy. Neurology, 1992, Volume: 42, Issue:4 Suppl 5 Topics: Animals; Anticonvulsants; Cleft Lip; Cleft Palate; Congenital Abnormalities; Diet; Epilepsy; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Forelimb; Fragile X Syndrome; Hindlimb; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Rabbits	1992

Trials

7 trial(s) available for folic acid and Harelip

Article	Year
Periconceptional use of folic acid and risk of miscarriage - findings of the Oral Cleft Prevention Program in Brazil. Journal of perinatal medicine, 2013, Volume: 41, Issue:4 Topics: Abortion, Spontaneous; Adult; Brazil; Cleft Lip; Cleft Palate; Double-Blind Method; Female; Folic Acid; Humans; Infant, Newborn; Male; Preconception Care; Pregnancy; Recurrence; Young Adult	2013
Oral folic acid supplementation decreases palate and/or lip cleft occurrence in Pug and Chihuahua puppies and elevates folic acid blood levels in pregnant bitches. Polish journal of veterinary sciences, 2013, Volume: 16, Issue:1 Topics: Administration, Oral; Animals; Cleft Lip; Cleft Palate; Dietary Supplements; Dog Diseases; Dogs; Female; Folic Acid; Pregnancy; Vitamins	2013
Folic acid use and nonsyndromic orofacial clefts in China: a prospective cohort study. Epidemiology (Cambridge, Mass.), 2012, Volume: 23, Issue:3 Topics: Adolescent; Adult; China; Cleft Lip; Cleft Palate; Drug Administration Schedule; Female; Folic Acid; Follow-Up Studies; Humans; Infant, Newborn; Logistic Models; Male; Medication Adherence; Population Surveillance; Pregnancy; Prenatal Care; Prospective Studies; Risk; Treatment Outcome; Vitamin B Complex; Young Adult	2012
Oral cleft prevention program (OCPP). BMC pediatrics, 2012, Nov-26, Volume: 12 Topics: Cleft Lip; Cleft Palate; Clinical Protocols; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Folic Acid; Follow-Up Studies; Humans; Infant, Newborn; Pilot Projects; Preconception Care; Pregnancy; Prenatal Care; Research Design; Secondary Prevention; Vitamin B Complex	2012
High dosage folic acid supplementation, oral cleft recurrence and fetal growth. International journal of environmental research and public health, 2013, Feb-04, Volume: 10, Issue:2 Topics: Adult; Brazil; Cleft Lip; Cleft Palate; Dietary Supplements; Double-Blind Method; Female; Fetal Development; Folic Acid; Humans; Pregnancy; Vitamin B Complex; Young Adult	2013
Reduced recurrence of orofacial clefts after periconceptional supplementation with high-dose folic acid and multivitamins. Teratology, 1995, Volume: 51, Issue:2 Topics: Adult; Child; Cleft Lip; Cleft Palate; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Male; Prospective Studies; Vitamins	1995
Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. The New England journal of medicine, 1992, Dec-24, Volume: 327, Issue:26 Topics: Cleft Lip; Congenital Abnormalities; Female; Folic Acid; Humans; Neural Tube Defects; Parity; Preconception Care; Pregnancy; Pregnancy Outcome; Prenatal Care; Trace Elements; Vitamins	1992

Other Studies

107 other study(ies) available for folic acid and Harelip

Article	Year
The relationship between maternal periconceptional micronutrient supplementation and non-syndromic cleft lip/palate in offspring. Birth defects research, 2023, 03-15, Volume: 115, Issue:5 Topics: Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Micronutrients; Mouth Abnormalities; Pregnancy; Risk Factors	2023
Characterization of 554 Mexican Patients With Nonsyndromic Cleft Lip and Palate: Descriptive Study. The Journal of craniofacial surgery, 2023, Sep-01, Volume: 34, Issue:6 Topics: Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Infant, Newborn; Mothers; Pregnancy	2023
Maternal consumption of caffeine and second-hand tobacco smoke as risk factors for the development of oral clefts. Clinics (Sao Paulo, Brazil), 2023, Volume: 78 Topics: Caffeine; Case-Control Studies; Child; Child, Preschool; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Infant; Infant, Newborn; Pregnancy; Risk Factors; Tobacco Smoke Pollution	2023
Descriptive epidemiology of external structural birth defects in Enugu State, Nigeria. Ghana medical journal, 2022, Volume: 56, Issue:4 Topics: Adult; Cleft Lip; Cleft Palate; Cross-Sectional Studies; Female; Folic Acid; Humans; Neural Tube Defects; Nigeria; Pregnancy; Prevalence; Stillbirth	2022
Cleft lip and palate risk factors among otorhinolaryngology: Head and neck surgery patients in two hospitals. Medicine, 2023, Oct-20, Volume: 102, Issue:42 Topics: Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Infant; Otolaryngology; Pregnancy; Retrospective Studies; Risk Factors	2023
Determinants and seasonality of major structural birth defects among newborns delivered at primary and referral hospital of East and West Gojjam zones, Northwest Ethiopia 2017-2018: case-control study. BMC research notes, 2019, Aug-09, Volume: 12, Issue:1 Topics: Adult; Alcohol Drinking; Case-Control Studies; Cleft Lip; Cleft Palate; Congenital Abnormalities; Developing Countries; Dietary Supplements; Ethiopia; Female; Fever; Folic Acid; Humans; Infant; Infant, Newborn; Male; Maternal Age; Musculoskeletal Abnormalities; Neural Tube Defects; Parturition; Pregnancy; Referral and Consultation; Risk Factors; Seasons; Urban Population	2019
Folate Deficiency Based Autism as an Orofacial Clefts/Neural Tube Defect Spectrum Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 2019, Volume: 58, Issue:11 Topics: Autistic Disorder; Child; Cleft Lip; Cleft Palate; Folic Acid; Humans; Neural Tube Defects; Neurodevelopmental Disorders	2019
Maternal Folic Acid Intake and Risk of Nonsyndromic Orofacial Clefts: A Hospital-Based Case-Control Study in Bangalore, India. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2020, Volume: 57, Issue:6 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Hospitals; Humans; India; Infant; Pregnancy; Risk Factors	2020
Concentrations of organochlorine pesticides in placental tissue are not associated with risk for fetal orofacial clefts. Reproductive toxicology (Elmsford, N.Y.), 2020, Volume: 98 Topics: Adult; China; Cleft Lip; Cleft Palate; Female; Fetus; Folic Acid; Humans; Hydrocarbons, Chlorinated; Infant, Newborn; Male; Maternal Exposure; Maternal-Fetal Exchange; Pesticides; Placenta; Pregnancy; Prenatal Injuries; Risk; Vitamin B Complex	2020
An overview of cleft lip and palate. JAAPA : official journal of the American Academy of Physician Assistants, 2020, Volume: 33, Issue:12 Topics: Breast Feeding; Cleft Lip; Cleft Palate; Folic Acid; Humans; Infant; Patient Care Team; Preoperative Care; Risk Factors	2020
Maternal Vitamin B The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2021, Volume: 58, Issue:5 Topics: Case-Control Studies; Child; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; India; Risk Factors; Vitamin B 12; Vitamins	2021
Maternal periconceptional folic acid supplementation reduced risks of non-syndromic oral clefts in offspring. Scientific reports, 2021, 06-10, Volume: 11, Issue:1 Topics: Adult; China; Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Male; Maternal Nutritional Physiological Phenomena; Nutrition Therapy; Risk Factors	2021
Maternal genotypes of folate/one-carbon metabolism gene variants and nonsyndromic cleft lip with or without cleft palate risk in Chile. European journal of oral sciences, 2021, Volume: 129, Issue:5 Topics: Carbon; Chile; Cleft Lip; Cleft Palate; Folic Acid; Genotype; Humans	2021
Risk factors for orofacial clefts in India: A case-control study. Birth defects research, 2017, Oct-02, Volume: 109, Issue:16 Topics: Adult; Brain; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; India; Infant; Infant, Newborn; Male; Mouth Abnormalities; Odds Ratio; Parity; Pregnancy; Risk Factors	2017
Evaluating LINE-1 methylation in cleft lip tissues and its association with early pregnancy exposures. Epigenomics, 2018, Volume: 10, Issue:1 Topics: Cleft Lip; Dietary Supplements; DNA Methylation; Female; Folic Acid; Humans; Infant; Long Interspersed Nucleotide Elements; Male; Maternal Exposure; Pregnancy	2018
A Study on Environmental Factors for Nonsyndromic Cleft Lip and/or Palate. The Journal of craniofacial surgery, 2018, Volume: 29, Issue:2 Topics: Brain; Case-Control Studies; Child, Preschool; Cleft Lip; Cleft Palate; Environmental Exposure; Female; Folic Acid; Humans; Male; Maternal Exposure; Pregnancy; Retrospective Studies; Risk Factors	2018
Family history and risk factors for cleft lip and palate patients and their associated anomalies. Stomatologija, 2017, Volume: 19, Issue:3 Topics: Cleft Lip; Cleft Palate; Consanguinity; Female; Folic Acid; Humans; Infant; Iran; Male; Pregnancy; Retrospective Studies; Risk Factors	2017
Evidence of interaction between genes in the folate/homocysteine metabolic pathway in controlling risk of non-syndromic oral cleft. Oral diseases, 2018, Volume: 24, Issue:5 Topics: Asian People; Betaine-Homocysteine S-Methyltransferase; Cleft Lip; Cleft Palate; Dimethylglycine Dehydrogenase; Epistasis, Genetic; Folic Acid; Genome-Wide Association Study; Homocysteine; Humans; Linkage Disequilibrium; Metabolic Networks and Pathways; Mitochondrial Proteins; Polymorphism, Single Nucleotide; Risk Factors; White People	2018
Supplementation with folic acid and orofacial clefts. Revista chilena de pediatria, 2017, Volume: 88, Issue:6 Topics: Cleft Lip; Cleft Palate; Folic Acid; Humans; Mouth Abnormalities	2017
Epigenomic profiling of newborns with isolated orofacial clefts reveals widespread DNA methylation changes and implicates metastable epiallele regions in disease risk. Epigenetics, 2019, Volume: 14, Issue:2 Topics: Case-Control Studies; Cleft Lip; Disease Susceptibility; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Folic Acid; Humans; Infant, Newborn; LIM-Homeodomain Proteins; Male; Maternal Exposure; MicroRNAs; Transcription Factors; Wnt Proteins	2019
Protective effect of folic acid on vulnerability to oxidative stress in dental pulp stem cells of deciduous teeth from children with orofacial clefts. Biochemical and biophysical research communications, 2019, 08-13, Volume: 516, Issue:1 Topics: Antioxidants; Cells, Cultured; Child; Cleft Lip; Cleft Palate; Dental Pulp; Folic Acid; Humans; Oxidative Stress; Stem Cells; Tooth, Deciduous; Vitamin B Complex	2019
Thymidylate synthase polymorphisms and risks of human orofacial clefts. Birth defects research. Part A, Clinical and molecular teratology, 2013, Volume: 97, Issue:2 Topics: 3' Untranslated Regions; Adult; California; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Fetus; Folic Acid; Homozygote; Humans; Infant, Newborn; Male; Middle Aged; Minisatellite Repeats; Polymorphism, Genetic; Pregnancy; Promoter Regions, Genetic; Racial Groups; Risk Factors; Sequence Deletion; Surveys and Questionnaires; Thymidylate Synthase	2013
Maternal dietary intake of nitrates, nitrites and nitrosamines and selected birth defects in offspring: a case-control study. Nutrition journal, 2013, Mar-21, Volume: 12 Topics: Adolescent; Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Confidence Intervals; Energy Intake; Feeding Behavior; Female; Folic Acid; Humans; Infant; Middle Aged; Neural Tube Defects; Nitrates; Nitrites; Nitrosamines; Odds Ratio; Pregnancy; Surveys and Questionnaires; Young Adult	2013
Lower concentrations of B-vitamin subgroups in the serum and amniotic fluid correlate to cleft lip and palate appearance in the offspring of A/WySn mice. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2013, Volume: 71, Issue:9 Topics: Adenine; Alkaline Phosphatase; Amniotic Fluid; Animals; Chromatography, High Pressure Liquid; Cleft Lip; Cleft Palate; Disease Models, Animal; Female; Folic Acid; Immunohistochemistry; Indicators and Reagents; Membrane Transport Proteins; Mice; Mice, Inbred Strains; Niacinamide; Nitroblue Tetrazolium; Palate; Pantothenic Acid; Pregnancy; Riboflavin; Thiamine; Vitamin B 6; Vitamin B Complex	2013
[Association study for gene polymorphism of folic acid/homocysteine metabolic pathway and nonsyndromic cleft lip with or without cleft palate in Chinese populations]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2013, Jun-18, Volume: 45, Issue:3 Topics: Asian People; Cleft Lip; Cleft Palate; Folic Acid; Genetic Linkage; Genome-Wide Association Study; Homocysteine; Humans; Logistic Models; Metabolic Networks and Pathways; Polymorphism, Single Nucleotide; Risk Factors	2013
Periconceptional folic acid associated with an increased risk of oral clefts relative to non-folate related malformations in the Northern Netherlands: a population based case-control study. European journal of epidemiology, 2013, Volume: 28, Issue:11 Topics: Adolescent; Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Confidence Intervals; Dietary Supplements; Female; Folic Acid; Humans; Male; Maternal Age; Multivariate Analysis; Netherlands; Odds Ratio; Population Surveillance; Pregnancy; Risk; Risk Factors; Socioeconomic Factors; Time Factors; Vitamin B Complex; Young Adult	2013
Micronutrients and oral clefts: a case-control study. Journal of dental research, 2013, Volume: 92, Issue:12 Topics: Animals; Calcium; Case-Control Studies; Cleft Lip; Cleft Palate; Common Cold; Contraceptive Agents, Female; Developing Countries; Diabetes Complications; Environment; Female; Folic Acid; Humans; Infant, Low Birth Weight; Infant, Newborn; Infant, Premature; Iron; Male; Meat; Micronutrients; Preconception Care; Risk Factors; Sex Factors; Swine; Thailand; Tretinoin; Vitamin A; Vitamin B Complex; Vitamins	2013
Is folic acid a risk factor for oral clefts? European journal of epidemiology, 2013, Volume: 28, Issue:11 Topics: Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Male; Pregnancy; Vitamin B Complex	2013
5,10-Methylenetetrahydrofolate reductase single nucleotide polymorphisms and gene-environment interaction analysis in non-syndromic cleft lip/palate. European journal of oral sciences, 2014, Volume: 122, Issue:2 Topics: Adenine; Adolescent; Case-Control Studies; Child; Child, Preschool; Cleft Lip; Cleft Palate; Cytosine; Female; Folic Acid; Gene Frequency; Gene-Environment Interaction; Genetic Variation; Genotype; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Preconception Care; Pregnancy; Prenatal Care; Risk Factors; Thymine; Vitamin B Complex	2014
The role of the folic acid to the prevention of orofacial cleft: an epidemiological study. Oral diseases, 2015, Volume: 21, Issue:2 Topics: Adolescent; Adult; Brazil; Case-Control Studies; Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Male; Maternal Nutritional Physiological Phenomena; Pregnancy; Randomized Controlled Trials as Topic; Retrospective Studies; Young Adult	2015
Genetic and non-genetic factors that increase the risk of non-syndromic cleft lip and/or palate development. Oral diseases, 2015, Volume: 21, Issue:3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Alcohol Drinking; Brain; Case-Control Studies; Child; Cleft Lip; Cleft Palate; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene-Environment Interaction; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Prenatal Exposure Delayed Effects; Replication Protein C; Young Adult	2015
The Association between Folate Pathway Genes and Cleft Lip With or Without Cleft Palate in a Chinese Population. Biomedical and environmental sciences : BES, 2015, Volume: 28, Issue:2 Topics: Adolescent; Adult; Brain; Child; Child, Preschool; China; Cleft Lip; Cleft Palate; Female; Folic Acid; Genotype; Humans; Infant; Male; Polymorphism, Single Nucleotide; Young Adult	2015
A Case-control Study of Environmental Risk Factors for Nonsyndromic Cleft of the Lip and/or Palate in Xuzhou, China. Biomedical and environmental sciences : BES, 2015, Volume: 28, Issue:7 Topics: Case-Control Studies; China; Cleft Lip; Cleft Palate; Environmental Pollutants; Female; Folic Acid; Humans; Infant, Newborn; Logistic Models; Maternal Exposure; Pregnancy; Risk Factors; Socioeconomic Factors; Surveys and Questionnaires	2015
Folic acid supplements and risk for oral clefts in the newborn: a population-based study. The British journal of nutrition, 2015, Nov-14, Volume: 114, Issue:9 Topics: Adult; Cleft Lip; Cleft Palate; Cohort Studies; Dietary Supplements; Female; Folic Acid; Humans; Infant, Newborn; Maternal Nutritional Physiological Phenomena; Norway; Pregnancy; Risk Factors; Vitamins; Young Adult	2015
Folic acid fortification and prevalences of neural tube defects, orofacial clefts, and gastroschisis in California, 1989 to 2010. Birth defects research. Part A, Clinical and molecular teratology, 2016, Volume: 106, Issue:12 Topics: California; Cleft Lip; Cleft Palate; Female; Folic Acid; Food, Fortified; Gastroschisis; Humans; Live Birth; Male; Neural Tube Defects; Pregnancy; Prevalence; Registries; Regression Analysis; Stillbirth	2016
Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate. American journal of medical genetics. Part A, 2016, Volume: 170, Issue:11 Topics: Alleles; California; Case-Control Studies; Cleft Lip; Cleft Palate; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Metabolic Networks and Pathways; Odds Ratio; Polymorphism, Single Nucleotide; Population Surveillance; Risk	2016
[Cleft lip/palate and flour fortification with folic acid in Chile]. Revista medica de Chile, 2016, Volume: 144, Issue:8 Topics: Chile; Cleft Lip; Cleft Palate; Flour; Folic Acid; Food, Fortified; Humans; Incidence; Infant; Infant, Newborn; Multivariate Analysis; Neural Tube Defects; Patient Discharge	2016
Folate and clefts of the lip and palate--a U.K.-based case-control study: Part I: Dietary and supplemental folate. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2008, Volume: 45, Issue:4 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Diet; Dietary Supplements; Female; Folic Acid; Humans; Infant, Newborn; Pregnancy; Surveys and Questionnaires; United Kingdom	2008
Folate and clefts of the lip and palate--a U.K.-based case-control study: Part II: Biochemical and genetic analysis. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2008, Volume: 45, Issue:4 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Fathers; Female; Folic Acid; Gene Frequency; Homocysteine; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Polymorphism, Single Nucleotide; Pregnancy; Regression Analysis; Surveys and Questionnaires; United Kingdom	2008
Genome-wide pathway analysis of folate-responsive genes to unravel the pathogenesis of orofacial clefting in man. Birth defects research. Part A, Clinical and molecular teratology, 2008, Volume: 82, Issue:9 Topics: Cell Line, Transformed; Child; Cleft Lip; Cleft Palate; Down-Regulation; Female; Folic Acid; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genome, Human; Humans; Male; Pilot Projects; Signal Transduction; Up-Regulation	2008
Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate. Birth defects research. Part A, Clinical and molecular teratology, 2008, Volume: 82, Issue:9 Topics: Amino Acid Substitution; Case-Control Studies; Child; Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Multicenter Studies as Topic; Polymorphism, Single Nucleotide; Pregnancy; Risk Factors	2008
Reduced folate carrier 1 (RFC1) is associated with cleft of the lip only. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2008, Volume: 41, Issue:8 Topics: Black People; Cleft Lip; Cleft Palate; DNA, Mitochondrial; Female; Folic Acid; Genetic Markers; Genetic Predisposition to Disease; Haplotypes; Humans; Indians, South American; Infant, Newborn; Membrane Transport Proteins; Polymorphism, Genetic; Reduced Folate Carrier Protein; South America; White People	2008
Oral facial clefts and gene polymorphisms in metabolism of folate/one-carbon and vitamin A: a pathway-wide association study. Genetic epidemiology, 2009, Volume: 33, Issue:3 Topics: Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Infant, Newborn; Linkage Disequilibrium; Male; Polymorphism, Single Nucleotide; Vitamin A	2009
Nested case-control study of one-carbon metabolites in mid-pregnancy and risks of cleft lip with and without cleft palate. Pediatric research, 2009, Volume: 66, Issue:5 Topics: Adult; Arginine; Carbon; Case-Control Studies; Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Maternal Age; Nutritional Sciences; Odds Ratio; Pregnancy; Vitamins	2009
Associations of folate and choline metabolism gene polymorphisms with orofacial clefts. Journal of medical genetics, 2010, Volume: 47, Issue:12 Topics: Betaine-Homocysteine S-Methyltransferase; Choline; Choline-Phosphate Cytidylyltransferase; Cleft Lip; Cleft Palate; Databases, Genetic; Epistasis, Genetic; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Metabolic Networks and Pathways; Polymorphism, Single Nucleotide	2010
The maternal homocysteine pathway is influenced by riboflavin intake and MTHFR polymorphisms without affecting the risk of orofacial clefts in the offspring. European journal of clinical nutrition, 2010, Volume: 64, Issue:3 Topics: Biomarkers; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Linear Models; Logistic Models; Methylenetetrahydrofolate Reductase (NADPH2); Nutrigenomics; Odds Ratio; Polymorphism, Genetic; Riboflavin; Risk Factors; Surveys and Questionnaires; Vitamin B 12	2010
Cleft lip and palate: an adverse pregnancy outcome due to undiagnosed maternal and paternal coeliac disease. Medical hypotheses, 2010, Volume: 75, Issue:1 Topics: Celiac Disease; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Male; Pregnancy; Pregnancy Outcome	2010
Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and/or palate in the Brazilian population. Birth defects research. Part A, Clinical and molecular teratology, 2010, Volume: 88, Issue:11 Topics: Adolescent; Adult; Brazil; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Minor Histocompatibility Antigens; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Pregnancy; Reduced Folate Carrier Protein; Risk Factors; Young Adult	2010
FPGS gene is a novel causative gene for cleft lip in China. Medical hypotheses, 2011, Volume: 76, Issue:3 Topics: China; Chromosome Mapping; Cleft Lip; Folic Acid; Genes; Genetic Linkage; Genetic Variation; Humans; Models, Genetic; Peptide Synthases	2011
Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection. Birth defects research. Part A, Clinical and molecular teratology, 2011, Volume: 91, Issue:1 Topics: Cell Adhesion Molecules; Cleft Lip; Cleft Palate; Folic Acid; Genes; Genetic Predisposition to Disease; Genotype; Hispanic or Latino; Humans; Interferon Regulatory Factors; Polymorphism, Single Nucleotide; White People	2011
Folate pathway and nonsyndromic cleft lip and palate. Birth defects research. Part A, Clinical and molecular teratology, 2011, Volume: 91, Issue:1 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Betaine-Homocysteine S-Methyltransferase; Carbon-Nitrogen Ligases; Cleft Lip; Cleft Palate; Folic Acid; Genes; Genetic Predisposition to Disease; Hispanic or Latino; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Thymidylate Synthase; White People	2011
Oral clefts and maternal biomarkers of folate-dependent one-carbon metabolism in Utah. Birth defects research. Part A, Clinical and molecular teratology, 2011, Volume: 91, Issue:3 Topics: Adult; Biomarkers; Carbon; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant, Newborn; Male; Metabolism, Inborn Errors; Mothers; Pregnancy; Risk Factors; Utah; Young Adult	2011
Maternal malnutrition, environmental exposure during pregnancy and the risk of non-syndromic orofacial clefts. Oral diseases, 2011, Volume: 17, Issue:6 Topics: Adult; Birth Weight; Calcium, Dietary; Case-Control Studies; Cleft Lip; Cleft Palate; Dietary Supplements; Environmental Exposure; Female; Folic Acid; Humans; Infant; Male; Malnutrition; Maternal Age; Parity; Pregnancy; Pregnancy Complications; Protective Agents; Risk Factors; Sex Factors; Tobacco Smoke Pollution; Vitamin B Complex; Weight Gain; Young Adult	2011
Association between inhibited binding of folic acid to folate receptor alpha in maternal serum and folate-related birth defects in Norway. Human reproduction (Oxford, England), 2011, Volume: 26, Issue:8 Topics: Adult; Autoantibodies; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folate Receptor 1; Folic Acid; Folic Acid Deficiency; Humans; Neural Tube Defects; Norway; Pregnancy	2011
Phenotype severity in the bladder exstrophy-epispadias complex: analysis of genetic and nongenetic contributing factors in 441 families from North America and Europe. The Journal of pediatrics, 2011, Volume: 159, Issue:5 Topics: Adult; Antacids; Bladder Exstrophy; Cleft Lip; Cleft Palate; Epispadias; Europe; Female; Fertilization in Vitro; Folic Acid; Humans; Male; Maternal Age; Middle Aged; North America; Paternal Age; Phenotype; Pregnancy; Pregnancy Trimester, First; Prenatal Care; Radiography; Risk Factors; Severity of Illness Index; Sex Distribution; Smoking; Sperm Injections, Intracytoplasmic; Surveys and Questionnaires; Vitamin B Complex	2011
Application of a novel hybrid study design to explore gene-environment interactions in orofacial clefts. Annals of human genetics, 2012, Volume: 76, Issue:3 Topics: Alcohol Drinking; Case-Control Studies; Cleft Lip; Cleft Palate; Coffee; Dietary Supplements; Female; Folic Acid; Gene-Environment Interaction; Humans; Maternal Exposure; Pregnancy; Research Design; Smoking; Vitamin A	2012
Taking folic acid at start of pregnancy seems to lower risk of cleft lip and palate. BMJ (Clinical research ed.), 2012, Jul-05, Volume: 345 Topics: Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Infant, Newborn; Preconception Care; Pregnancy; Prenatal Care; Vitamin B Complex	2012
Use of folic acid supplements and risk of cleft lip and palate in infants: a population-based cohort study. The British journal of general practice : the journal of the Royal College of General Practitioners, 2012, Volume: 62, Issue:600 Topics: Cleft Lip; Cleft Palate; Cross-Sectional Studies; Female; Folic Acid; Humans; Infant; Ireland; Male; Preconception Care; Pregnancy; Prevalence; Risk Factors; Sex Distribution	2012
Association of interactions among the IRF6 gene, the 8q24 region, and maternal folic acid intake with non-syndromic cleft lip/palate in Mexican Mestizos. American journal of medical genetics. Part A, 2012, Volume: 158A, Issue:12 Topics: Case-Control Studies; Chromosomes, Human, Pair 8; Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Variation; Humans; Infant; Interferon Regulatory Factors; Male; Mexico; Pregnancy	2012
Descriptive epidemiology of cleft lip and cleft palate in Western Australia. Birth defects research. Part A, Clinical and molecular teratology, 2013, Volume: 97, Issue:2 Topics: Adult; Child, Preschool; Chromosome Aberrations; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Infant; Infant, Newborn; Live Birth; Male; Native Hawaiian or Other Pacific Islander; Pregnancy; Prevalence; Registries; Retrospective Studies; Social Class; Stillbirth; Western Australia; White People	2013
[Genetic differences in enzymes of folic acid metabolism in patients with lip-jaw-palate clefts and their relatives]. Mund-, Kiefer- und Gesichtschirurgie : MKG, 2002, Volume: 6, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arylamine N-Acetyltransferase; Child; Child, Preschool; Cleft Lip; Cleft Palate; DNA Mutational Analysis; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Reference Values; Risk	2002
Does the interaction between maternal folate intake and the methylenetetrahydrofolate reductase polymorphisms affect the risk of cleft lip with or without cleft palate? American journal of epidemiology, 2003, Apr-01, Volume: 157, Issue:7 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Confidence Intervals; Female; Folic Acid; Genotype; Humans; Infant, Newborn; Male; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy	2003
Exploring the effects of methylenetetrahydrofolate reductase gene variants C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads. American journal of epidemiology, 2003, Jun-15, Volume: 157, Issue:12 Topics: Adolescent; Adult; Alanine; Case-Control Studies; Cleft Lip; Cleft Palate; Cysteine; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Haplotypes; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Norway; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Registries; Risk Factors; Threonine	2003
Study of 400 pregnancies with birth of cleft lip-palate infants; protective effect of folic acid and vitamin B6 therapy. Plastic and reconstructive surgery and the transplantation bulletin, 1958, Volume: 22, Issue:5 Topics: Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Infant; Nutrition Therapy; Parturition; Pregnancy; Vitamin B 6	1958
Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial and conotruncal heart defects. American journal of epidemiology, 2003, Oct-15, Volume: 158, Issue:8 Topics: California; Carrier Proteins; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Variation; Genotype; Heart Defects, Congenital; Humans; Infant; Membrane Proteins; Membrane Transport Proteins; Pregnancy; Risk Factors	2003
Maternal drug use and infant cleft lip/palate with special reference to corticoids. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2003, Volume: 40, Issue:6 Topics: Abnormalities, Drug-Induced; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Cleft Lip; Cleft Palate; Confidence Intervals; Female; Folic Acid; Glucocorticoids; Humans; Infant, Newborn; Naproxen; Odds Ratio; Pharmaceutical Preparations; Pregnancy; Pregnancy Trimester, First; Prospective Studies; Registries; Sulfasalazine; Sweden; Vitamins	2003
Vitamin and homocysteine status of mothers and infants and the risk of nonsyndromic orofacial clefts. American journal of obstetrics and gynecology, 2003, Volume: 189, Issue:4 Topics: Cleft Lip; Cleft Palate; Female; Folic Acid; Homocysteine; Humans; Infant; Mothers; Pyridoxal Phosphate; Risk Factors; Vitamin B 12; Vitamin B 6	2003
Cleft palate, transforming growth factor alpha gene variants, and maternal exposures: assessing gene-environment interactions in case-parent triads. Genetic epidemiology, 2003, Volume: 25, Issue:4 Topics: Adult; Alcohol Drinking; Alleles; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Gene Frequency; Genetic Variation; Genotype; Humans; Infant; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Nuclear Family; Pregnancy; Prenatal Exposure Delayed Effects; Smoking; Software; Transforming Growth Factor alpha; Vitamins	2003
Association between folic acid food fortification and congenital orofacial clefts. The Journal of pediatrics, 2003, Volume: 143, Issue:6 Topics: Canada; Cleft Lip; Cleft Palate; Female; Folic Acid; Food, Fortified; Hematinics; Humans; Infant, Newborn; Pregnancy; Program Evaluation; Retrospective Studies	2003
Maternal dietary B vitamin intake, other than folate, and the association with orofacial cleft in the offspring. European journal of nutrition, 2004, Volume: 43, Issue:1 Topics: Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Diet; Energy Intake; Female; Folic Acid; Humans; Infant, Newborn; Niacin; Preconception Care; Pregnancy; Prenatal Care; Pyridoxine; Riboflavin; Risk Reduction Behavior; Surveys and Questionnaires; Thiamine; Vitamin B 12; Vitamin B Complex	2004
Myo-inositol, glucose and zinc status as risk factors for non-syndromic cleft lip with or without cleft palate in offspring: a case-control study. BJOG : an international journal of obstetrics and gynaecology, 2004, Volume: 111, Issue:7 Topics: Adult; Blood Glucose; Case-Control Studies; Cleft Lip; Cleft Palate; Dietary Supplements; Erythrocytes; Female; Folic Acid; Humans; Infant; Inositol; Male; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Risk Factors; Zinc	2004
Maternal vitamin B-6 and folate status and risk of oral cleft birth defects in the Philippines. Birth defects research. Part A, Clinical and molecular teratology, 2004, Volume: 70, Issue:7 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Male; Mothers; Philippines; Risk Factors; Vitamin B 6	2004
Periconceptional folate intake by supplement and food reduces the risk of nonsyndromic cleft lip with or without cleft palate. Preventive medicine, 2004, Volume: 39, Issue:4 Topics: Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Dietary Supplements; Eating; Female; Folic Acid; Humans; Netherlands; Pregnancy; Risk Factors; Socioeconomic Factors; Surveys and Questionnaires; Time Factors	2004
Periconceptional multivitamin intake during early pregnancy, genetic variation of acetyl-N-transferase 1 (NAT1), and risk for orofacial clefts. Birth defects research. Part A, Clinical and molecular teratology, 2004, Volume: 70, Issue:11 Topics: Adult; Arylamine N-Acetyltransferase; Case-Control Studies; Cleft Lip; Cleft Palate; Cohort Studies; Dietary Supplements; Female; Folic Acid; Genetic Variation; Genotype; Humans; Infant; Infant, Newborn; Isoenzymes; Male; Polymorphism, Genetic; Preconception Care; Pregnancy; Risk Factors	2004
Changing lifestyles and oral clefts occurrence in Denmark. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2005, Volume: 42, Issue:3 Topics: Cleft Lip; Cleft Palate; Confounding Factors, Epidemiologic; Denmark; Female; Folic Acid; Humans; Infant, Newborn; Life Style; Logistic Models; Pregnancy; Prenatal Care; Prevalence; Smoking	2005
Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial defects and congenital heart defects in China. Annals of epidemiology, 2006, Volume: 16, Issue:5 Topics: Case-Control Studies; China; Cleft Lip; Cleft Palate; Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Membrane Transport Proteins; Polymorphism, Genetic; Reduced Folate Carrier Protein; Risk; Vitamin B Complex	2006
Maternal employment status and isolated orofacial clefts in Hungary. Central European journal of public health, 2005, Volume: 13, Issue:3 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Employment; Female; Folic Acid; Humans; Hungary; Infant, Newborn; Logistic Models; Male; Maternal Age; Multivariate Analysis; Occupations; Pregnancy; Prenatal Care; Socioeconomic Factors; Vitamins	2005
[Periconceptional folates and the prevention of orofacial clefts: role of dietary intakes in France]. Revue d'epidemiologie et de sante publique, 2005, Volume: 53, Issue:4 Topics: Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Male; Prenatal Care; Vitamin B Complex	2005
Variable contribution of the MTHFR C677T polymorphism to non-syndromic cleft lip and palate risk in China. American journal of medical genetics. Part A, 2006, Mar-15, Volume: 140, Issue:6 Topics: Adult; Alleles; Asian People; China; Cleft Lip; Cleft Palate; Female; Folic Acid; Gene Frequency; Genotype; Geography; Humans; Infant, Newborn; Linkage Disequilibrium; Logistic Models; Male; Maternal Age; Methylenetetrahydrofolate Reductase (NADPH2); Nuclear Family; Point Mutation; Polymorphism, Single Nucleotide; Risk Factors; Surveys and Questionnaires; Syndrome; Vitamin B Complex	2006
Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate. Human mutation, 2006, Volume: 27, Issue:3 Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alleles; Cleft Lip; Cleft Palate; Ferredoxin-NADP Reductase; Folic Acid; Gene Expression Regulation; Genetic Markers; Genetic Predisposition to Disease; Humans; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Transcobalamins	2006
Maternal folate receptor autoantibodies and cleft lip and/or palate. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2006, Volume: 93, Issue:2 Topics: Adult; Autoantibodies; Carrier Proteins; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folate Receptors, GPI-Anchored; Folic Acid; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Receptors, Cell Surface	2006
Periconceptional health and lifestyle factors of both parents affect the risk of live-born children with orofacial clefts. Birth defects research. Part A, Clinical and molecular teratology, 2006, Volume: 76, Issue:8 Topics: Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Health Status; Humans; Infant, Newborn; Life Style; Male; Netherlands; Parents; Pregnancy; Risk Factors	2006
Pacific Craniofacial Team and Cleft Prevention Program. Journal of the California Dental Association, 2006, Volume: 34, Issue:10 Topics: California; Cleft Lip; Cleft Palate; Developing Countries; Female; Folic Acid; Folic Acid Deficiency; Humans; Infant, Newborn; Interferon Regulatory Factors; Maternal Nutritional Physiological Phenomena; MSX1 Transcription Factor; Patient Care Team; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Reduced Folate Carrier Protein; Schools, Dental; Transforming Growth Factor beta3	2006
Reduction in orofacial clefts following folic acid fortification of the U.S. grain supply. Birth defects research. Part A, Clinical and molecular teratology, 2007, Volume: 79, Issue:1 Topics: Cleft Lip; Cleft Palate; Edible Grain; Female; Folic Acid; Food Supply; Food, Fortified; Humans; Preconception Care; Pregnancy; Prenatal Care; Prevalence; Racial Groups; United States	2007
Fetal and maternal MTHFR C677T genotype, maternal folate intake and the risk of nonsyndromic oral clefts. American journal of medical genetics. Part A, 2007, Feb-01, Volume: 143A, Issue:3 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Diet; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Genetic; Pregnancy	2007
Folic acid supplements and risk of facial clefts: national population based case-control study. BMJ (Clinical research ed.), 2007, Mar-03, Volume: 334, Issue:7591 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Humans; Infant, Newborn; Norway; Preconception Care; Pregnancy; Prenatal Care; Vitamins	2007
Folic acid supplements taken early in pregnancy reduce facial cleft risk. Journal of the American Dental Association (1939), 2007, Volume: 138, Issue:4 Topics: Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Pregnancy; Vitamin B Complex	2007
Diet & nutrition. Good news: caffeine in pregnancy doesn't affect the baby's growth...and folic acid seems to prevent cleft lip. Child health alert, 2007, Volume: 25 Topics: Birth Weight; Caffeine; Central Nervous System Stimulants; Cleft Lip; Coffee; Female; Fetal Development; Folic Acid; Humans; Infant, Newborn; Pregnancy; Pregnancy Trimester, Second; Vitamin B Complex	2007
[Association between environmental risk factor exposure in the first trimester and nonsyndromic cleft lip with or without cleft palate: a case-control study]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2007, Volume: 27, Issue:4 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Maternal Exposure; Pregnancy; Pregnancy Trimester, First; Risk Factors; Stress, Psychological	2007
Maternal periconceptional alcohol consumption and risk of orofacial clefts. American journal of epidemiology, 2007, Oct-01, Volume: 166, Issue:7 Topics: Adolescent; Adult; Alcohol Drinking; Case-Control Studies; Centers for Disease Control and Prevention, U.S.; Cleft Lip; Cleft Palate; Congenital Abnormalities; Female; Folic Acid; Humans; Maternal Exposure; Nutritional Status; Odds Ratio; Phenotype; Pregnancy; Prenatal Exposure Delayed Effects; Risk Assessment; Risk Factors; Risk-Taking; Time Factors; United States	2007
Folate and one-carbon metabolism gene polymorphisms and their associations with oral facial clefts. American journal of medical genetics. Part A, 2008, Feb-15, Volume: 146A, Issue:4 Topics: Carbon; Case-Control Studies; Cleft Lip; Cleft Palate; Dietary Supplements; Female; Folic Acid; Gene Frequency; Humans; Infant, Newborn; Male; Metabolic Networks and Pathways; Models, Biological; Polymorphism, Genetic; Pregnancy	2008
Homocysteine and folate status in an era of folic acid fortification: balancing benefits, risks, and B-vitamins. Clinical chemistry, 2008, Volume: 54, Issue:5 Topics: Cleft Lip; Cleft Palate; Folic Acid; Food, Fortified; Homocysteine; Humans; Neural Tube Defects; Nutrition Surveys; Risk Assessment; Vitamin B Complex	2008
Periconceptional supplementation with vitamins and folic acid to prevent recurrence of cleft lip. Lancet (London, England), 1982, Jul-24, Volume: 2, Issue:8291 Topics: Cleft Lip; Female; Folic Acid; Humans; Maternal-Fetal Exchange; Pregnancy; Prenatal Care; Recurrence; Vitamins	1982
Risks of orofacial clefts in children born to women using multivitamins containing folic acid periconceptionally. Lancet (London, England), 1995, Aug-12, Volume: 346, Issue:8972 Topics: Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Edible Grain; Female; Folic Acid; Food, Fortified; Humans; Infant, Newborn; Preconception Care; Pregnancy; Prenatal Care; Risk; Vitamins	1995
Case-control study of periconceptional folic acid supplementation and oral clefts. American journal of epidemiology, 1996, Jun-15, Volume: 143, Issue:12 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Confidence Intervals; Female; Folic Acid; Humans; Infant; Infant, Newborn; Mouth Abnormalities; Multivariate Analysis; Pregnancy; Risk Factors	1996
Orofacial clefts in Hungary. Epidemiological and genetic data, primary prevention. Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP), 1997, Volume: 49, Issue:3-4 Topics: Cleft Lip; Cleft Palate; Cross-Sectional Studies; Female; Folic Acid; Humans; Hungary; Incidence; Infant, Newborn; Male; Pregnancy; Vitamins	1997
Infant TGF-alpha genotype, orofacial clefts, and maternal periconceptional multivitamin use. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 1998, Volume: 35, Issue:4 Topics: Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Cohort Studies; Confidence Intervals; DNA; Female; Folic Acid; Genotype; Heterozygote; Homozygote; Humans; Infant, Newborn; Interviews as Topic; Male; Odds Ratio; Phenotype; Polymorphism, Genetic; Population Surveillance; Preconception Care; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors; Smoking; Transforming Growth Factor alpha; Vitamins	1998
Methylenetetrahydrofolate reductase thermolabile variant and oral clefts. American journal of medical genetics, 1999, Sep-03, Volume: 86, Issue:1 Topics: Child; Cleft Lip; Cleft Palate; Enzyme Stability; Family Health; Female; Folic Acid; Gene Frequency; Homozygote; Humans; Infant, Newborn; Ireland; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Temperature	1999
Nonsyndromic orofacial clefts: association with maternal hyperhomocysteinemia. Teratology, 1999, Volume: 60, Issue:5 Topics: Adult; Case-Control Studies; Child, Preschool; Cleft Lip; Cleft Palate; Erythrocytes; Fasting; Female; Folic Acid; Homocysteine; Humans; Infant; Maternal-Fetal Exchange; Methionine; Pregnancy; Pyridoxine; Risk Factors; Vitamin B 12	1999
Influence of folic acid on pregnant women. The British journal of oral & maxillofacial surgery, 1999, Volume: 37, Issue:5 Topics: Animals; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Pregnancy	1999
Dose-dependent effect of folic acid on the prevention of orofacial clefts. Pediatrics, 1999, Volume: 104, Issue:6 Topics: Adult; Case-Control Studies; Cleft Lip; Cleft Palate; Dose-Response Relationship, Drug; Female; Folic Acid; Humans; Hungary; Infant, Newborn; Logistic Models; Male; Pregnancy; Prenatal Care; Prospective Studies; Registries; Vitamins	1999
Folic acid antagonists during pregnancy and the risk of birth defects. The New England journal of medicine, 2000, Nov-30, Volume: 343, Issue:22 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Case-Control Studies; Cleft Lip; Dietary Supplements; Female; Folic Acid; Folic Acid Antagonists; Heart Defects, Congenital; Humans; Logistic Models; Pregnancy; Urinary Tract; Vitamins	2000
Oral clefts and vitamin supplementation. The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2001, Volume: 38, Issue:1 Topics: Brazil; Case-Control Studies; Chi-Square Distribution; Cleft Lip; Cleft Palate; Confidence Intervals; Confounding Factors, Epidemiologic; Dietary Supplements; Environment; Female; Folic Acid; Humans; Infant; Interviews as Topic; Likelihood Functions; Male; Multivariate Analysis; Neural Tube Defects; Odds Ratio; Phenotype; Population Surveillance; Preconception Care; Pregnancy; Prenatal Care; Protective Agents; Surveys and Questionnaires; Vitamins	2001
Maternal multivitamin use and orofacial clefts in offspring. Teratology, 2001, Volume: 63, Issue:2 Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Georgia; Humans; Pregnancy; Vitamins	2001
Vitamin supplementation as a possible factor in the incidence of cleft lip/palate deformities in humans. Clinics in plastic surgery, 1976, Volume: 3, Issue:4 Topics: Ascorbic Acid; Calcium; Cleft Lip; Cleft Palate; Female; Folic Acid; Humans; Infant, Newborn; Maternal-Fetal Exchange; Niacinamide; Pregnancy; Pregnancy Trimester, First; Pyridoxine; Riboflavin; Thiamine; Vitamin B 12; Vitamins	1976
Congenital malformations due to anticonvulsive drugs. Obstetrics and gynecology, 1975, Volume: 45, Issue:4 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Adult; Anencephaly; Anticonvulsants; Birth Order; Cleft Lip; Cleft Palate; Epilepsy; Female; Fetal Death; Folic Acid; Folic Acid Antagonists; Hemorrhage; Humans; Infant, Newborn; Male; Maternal-Fetal Exchange; Phenobarbital; Phenytoin; Pregnancy; Pregnancy Complications; Primidone; Trimethadione	1975
Lack of maternal metabolic, endocrine, and environmental influences in the etiology of cleft lip with or without cleft palate. The Cleft palate journal, 1985, Volume: 22, Issue:1 Topics: Adult; Cleft Lip; Cleft Palate; Drug Interactions; Endocrine Glands; Erythrocytes; Female; Folic Acid; Humans; Kinetics; Maternal-Fetal Exchange; Phenytoin; Pregnancy; Prenatal Exposure Delayed Effects; Retrospective Studies; Risk	1985