Compounds > folic acid
Page last updated: 2024-08-17

folic acid and Genetic Predisposition

folic acid has been researched along with Genetic Predisposition in 488 studies

Research

Studies (488)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's12 (2.46)18.2507
2000's205 (42.01)29.6817
2010's241 (49.39)24.3611
2020's30 (6.15)2.80

Authors

AuthorsStudies
Chimenti, MS; Conigliaro, P; D'Antonio, A; De Carolis, C; De Martino, E; Ferrigno, S; Giambini, I; Greco, E; Perricone, C; Triggianese, P1
Chen, X; Huang, X; Jie, D; Shao, W; Wang, G; Wang, X; Zhang, B; Zhang, W; Zheng, C1
Mukhopadhyay, K; Rajamma, U; Saha, S; Saha, T; Sinha, S1
Assunção, LDP; Bento, DDCP; da Costa, CCP; da Silva Reis, AA; de Lima, NS; Santos, KF; Santos, RDS1
Chen, X; Huang, X; Wang, X; Zhang, W; Zheng, C1
Antonsson, A; Green, AC; Hughes, MCB; Liyanage, UE; Rodriguez-Acevedo, AJ; van der Pols, JC1
Liu, Y; Qin, J; Shu, J; Song, X; Sun, M; Wei, J; Zhu, P1
Cherniavska, Y; Fishchuk, L; Gorovenko, N; Pokhylko, V; Popova, O; Rossokha, Z; Tsvirenko, S1
Abidi, O; Baba, H; Bensghir, R; Bouqdayr, M; Kettani, A; Marih, L; Ouladlahsen, A; Saih, A; Sodqi, M; Wakrim, L; Zaidane, I1
Abbas, AM; Alenazy, FO; Alhassan, HH; Davuljigari, CB; Elderdery, AY; Elkhalifa, AME; Mills, J; Shalabi, MG; Tebein, EM1
Du, M; Mclaughlin, JR; Parfrey, PS; Shariati, M; Vallis, J; Wang, PP; Wang, Y; Zhu, Y1
Hu, S; Lai, M; Liu, Y; Pu, G; Tao, P; Wang, Y; Wang, Z; Xu, C; Yang, C; Zhang, L1
Chen, R; Deng, D; He, J; Huang, H; Zhou, Y1
Balarin, MAS; Cintra, MTR; Gomes, MKO; Lima, MFP; Paula, HK; Resende, EAMR; Santos, TBD; Silva-Grecco, RL1
Ding, X; Ding, Y; Mo, W; Zheng, Y; Zou, D1
Fu, S; Jia, X; Li, Q; Saleem, K; Sun, W; Xu, L; Zaib, T1
Du, B; Huang, X; Li, D; Ren, B; Yue, L; Zhang, C; Zhang, W; Zhao, Q1
Ahn, TK; An, HJ; Choi, UY; Han, IB; Kim, JO; Kim, KT; Kim, NK; Park, HS; Sohn, S1
Ashley-Koch, A; Au, KS; Baker, C; Brown, M; Hebert, L; Hillman, P; Hixson, J; Morrison, AC; Northrup, H1
Albert, A; Andrighetti, H; Austin, J; Batallones, R; Carrion, P; Dyer, R; Hippman, C; Honer, W; Inglis, A; Morris, E; Ross, C; Slomp, C1
Batista Arantes, LMR; De Castro, TB; Galbiatti-Dias, ALS; Maniglia, JV; Maria Goloni Bertollo, E; Oliveira-Cucolo, JG; Pavarino, EC; Raposo, LS; Rodrigues-Fleming, GH; Silva, FP; Silva, JNGD1
Guan, Z; Guo, J; Li, S; Niu, B; Wang, J; Wang, X; Yue, H; Zhang, T; Zhu, Z1
Burgess, S; Carter, P; Kar, S; Larsson, SC; Mason, AM; Vithayathil, M; Yuan, S1
Chen, L; Diao, J; Huang, P; Li, F; Li, J; Li, Y; Luo, L; Qin, J; Sun, M; Wang, T; Zhang, S; Zhu, P1
Abdelhay, E; Bernardo, PS; Dos Santos, EC; Petrone, I1
Accorsi, P; Bestetti, I; Brunetti, S; Giordano, L; Guerrini, R; Malerba, L; Palumbo, G; Parazzini, C; Parrini, E1
Jin, HJ; Kang, YD; Kim, HJ; Kim, JS; Kwon, BN; Lee, NR; Park, JW1
Ancer-Rodríguez, PR; Calvo-Anguiano, G; Calzada-Dávila, M; Campos-Acevedo, LD; González-Peña, SM; Guerrero-Orjuela, LS; Hernández-Almaguer, MD; Lugo-Trampe, JJ; Martínez-de-Villarreal, LE; Saldivar-Rodríguez, D1
Arantes, LMRB; Biselli, JM; Carvalho, AL; Carvalho, VM; Eberlin, MN; Goloni-Bertollo, EM; Melendez, ME; Mendes, CC; Pavarino, ÉC; Riccio, MF; Vannucchi, H; Zampieri, BL1
Guan, Y; Hellwege, JN; Hu, H; Liang, X; Linkermann, A; Liu, H; Ma, Z; Miao, Z; Susztak, K; Voight, BF1
Cha, L; Dai, Y; Han, B; Jin, E; Li, X; Weng, L; Yan, S1
Aksoy-Sagirli, P; Erdenay, A; Kaytan-Saglam, E; Kizir, A1
Brody, LC; Molloy, AM; Pangilinan, F1
Grarup, N; Hansen, T; Linneberg, A; Mortensen, EL; Møllehave, LT; Pedersen, O; Sandholt, CH; Simonsen, KS; Skaaby, T; Thuesen, BH1
Dai, XL; Jin, MH; Liu, GC; Mi, NN; Ren, XY; Wang, J; Wang, SQ; Zhang, J1
Chay, WY; Chia, JWK; Choo, SP; Dent, RA; Koh, KX; Koo, WH; Kwok, LL; Lo, SK; Loh, M; Mok, ZY; Ng, RCH; Soong, RCT; Syn, N; Tan, S; Tham, CK; Toh, HC; Wong, NS; Yap, YS1
Ebrahimi, A; Hosseinzadeh Colagar, A; Karimian, M1
Elizabeth, KE; Jissa, VT; Pillai, MR; Praveen, SL; Preethi, NR1
Karimian, M; Keshavarzi, F; Mohammadpour-Gharehbagh, A; Moodi, M; Mousavi, M; Salimi, S; Sandoughi, M1
Au, KS; Findley, TO; Hixson, JE; Morrison, AC; Northrup, H; O'Byrne, MR; Tenpenny, JC1
Li, S; Liu, J; Yu, L; Zhang, Z1
Akka, J; Dudekula, D; Jangala, M; Koralla, M; Manche, SK1
Molloy, AM1
Cai, C; Cao, L; Fang, Y; Wang, Y; Zhang, R; Zhao, L; Zhi, X1
Kang, SS; Rosenson, RS1
A, J; B, S; K, RP; T, MK; T, S1
Gong, JM; He, YX; Shan, WW; Shen, Y1
Fan, B; Kang, JH; Levkovitch-Verbin, H; Pasquale, LR; Wiggs, JL1
Alrokayan, SA; Hussain, T; Indumathi, B; Kutala, VK; Naushad, SM; Samreen, K1
Lintas, C1
Eminovic, I; Mackic-Djurovic, M; Nefic, H1
Duan, S; Feng, Z; Li, G; Ma, X; Qiu, F; Wang, L; Zhao, L; Zhao, M1
Bankura, B; Das, M; Munian, D; Paul, S; Sadhukhan, S1
Brandmayr, W; Enko, D; Halwachs-Baumann, G; Kriegshäuser, G; Meinitzer, A; Schnedl, WJ1
Luo, L; Tian, Y; Wang, X; Wei, H; Wu, Y1
Shute, C1
Gai, A; Govone, F; Rainero, I; Roveta, F; Rubino, E; Vacca, A1
Mansoor, A; Mazhar, K; Micheal, S; Mirza, B; Qamar, R; Siddiqi, S; Ullah, N1
Chandra, PS; Chosdol, K; Debnath, E; Gowda, SH; Gupta, DK; Gupta, Y; Kumawat, R; Lakshmy, R; Niwas, R; Rashid, S; Sarkar, C; Sinha, S; Suri, A; Upadaya, AD1
Denisova, AG; Drujinina, TA; Kulyutsina, ER; Levashova, OA; Tatarchenko, IP1
Agopian, AJ; Benjamin, RH; Browne, ML; Canfield, MA; Finnell, RH; Hoang, TT; Lei, Y; Lupo, PJ; McKenzie, P; Mitchell, LE; Sharma, SV; Shaw, G; Swartz, MD; Waller, DK1
Arora, R; Bansal, AK; Bhattacharya, R; Hasan, T; Sharma, GS; Singh, LR1
Dai, L; Deng, C; Deng, Y; Liu, H; Liu, L; Xie, L; Yu, L1
Du, B; He, Y; Li, D; Ren, B; Yue, L; Zhang, C; Zhang, W; Zhao, Q1
Ahn, EH; An, HJ; Kim, JH; Kim, JO; Kim, NK; Kim, YR; Ko, EJ; Lee, WS; Park, HS; Ryu, CS1
Fu, J; Huang, J; Li, Q; Lin, Z; Sun, Y; Wang, W; Xu, J; Zeng, D1
Aloui, M; Baara, A; Ben Fradj, MK; Ben Halima, M; Ben Jemaa, N; Ben Wafi, S; Boulares, M; Feki, M; Gaigi, SS; Jemaa, R; Kallel, A; Lassoued, M; Mahjoubi, I; Marrakchi, R; Midani, F; Nasri, K; Omar, S; Soussi, M1
Jadavji, NM; Murray, LK1
Dandrieux, JR; German, AJ; Halladay, LJ; McLean, L; Noble, PJ1
Chen, XY; Wen, YY; Yang, SJ; Zhang, JX1
Ding, LH; Gao, S; Li, CB; Wang, JW; Wang, ZY1
Bezerra, LC; D'Almeida, V; de Carvalho, SC; de Oliveira, CP; Gomes, AV; Muniz, MT; Pereira, LM; Silva, KA; Siqueira, ER; Siqueira, MD1
Delaney, C; Hewagama, A; Hoeltzel, MF; Johnson, K; Mickelson, B; Richardson, BC; Sawalha, AH; Strickland, FM; Wu, A; Yung, R1
Pu, D; Shen, Y; Wu, J1
Chen, Y; Jiang, D; Li, H; Liu, M; Mao, J; Wang, B; Yan, W1
Copp, AJ; Greene, ND; Stanier, P1
Aguilar, M; Bannasch, DL; Bassuk, AG; Coulson, RL; Dickinson, PJ; Ferguson, PJ; Hitchens, PL; Safra, N; Thomas, N; Vernau, KM; Wolf, ZT1
Bentham, J; Bhattacharya, S; Blue, G; Breckpot, J; Brody, LC; Brook, JD; Brown, DL; Bu'Lock, FA; Cordell, HJ; Cosgrove, C; Devriendt, K; Doza, JP; Druschel, C; Farrall, M; Gewillig, M; Goodship, JA; Hall, D; Keavney, BD; Lathrop, GM; Mamasoula, C; Mills, JL; Moorman, AF; Mulder, BJ; O'Sullivan, J; Pangilinan, F; Pass, K; Pierscionek, T; Postma, AV; Prentice, RR; Rahman, TJ; Rauch, A; Riveron, JG; Russell, MW; Setchfield, K; Stuart, AG; Tan, HL; Thornborough, C; Töpf, A; van Engelen, K; Winlaw, D; Zelenika, D; Zwinderman, AH1
Cha, SH; Choi, YS; Jeon, YJ; Kim, JH; Kim, NK; Kim, YR; Lee, BE; Lee, WS; Rah, H; Shin, JE1
Been, RA; DeCoursin, KJ; Hooten, AJ; Janik, CL; Johnson, KJ; Langer, EK; Largaespada, DA; Linden, MA; Marek, CA; Nagel, CW; Reed, RC; Ross, JA; Schutten, MM1
Antal, P; Erdélyi, DJ; Falus, A; Gézsi, A; Hullám, G; Kovács, G; Kutszegi, N; Lautner-Csorba, O; Semsei, ÁF; Szalai, C1
Ateş, O; Bozkurt, N; Kalkan, G; Karakuş, N; Ozdemir, A; Pancar, GŞ; Yigit, S1
Ambrosone, CB; Bandera, EV; Bovbjerg, DH; Chandran, U; Ciupak, G; Gong, Z; Hong, CC; Hwang, H; Jandorf, L; Khoury, T; Lu, Q; McCann, SE; Pawlish, K; Wiam, B; Zirpoli, G1
Cao, Z; Du, Y; Gong, T; Guo, Y; Lin, X; Qi, L; Shen, M; Yang, M1
Chen, P; Chu, R; Guo, H; Hu, P; Li, C; Li, J; Li, M; Li, X; Wang, H; Zhang, W1
Antonucci, I; Barone, C; Bosco, P; Coppedè, F; Lorenzoni, V; Migheli, F; Migliore, L; Romano, C; Stuppia, L1
Deng, LQ; Liu, Y; Xiao, QK; Xu, XM; Zhou, LS1
Gu, YH; Hua, W; Jiang, J; Liu, N; Qi, JP; Song, HS; Song, YJ; Sun, Y; Tong, ZG; Wu, H; Zhao, SG; Zhu, JY1
Liu, J; Luo, X; Ning, Q; Qi, J; Yu, X; Zhang, L; Zhu, J1
Cai, HZ; Huang, GL; Su, M; Sun, GJ; Wang, SK; Wang, TT; Yin, H1
Guan, T; Guan, Z; Guo, J; Li, G; Niu, B; Wang, F; Wang, G; Wang, J; Wang, M; Wang, X; Xiang, Q; Xie, Q; Zhang, T; Zhang, Z; Zhu, Z1
Alam, R; Kalaivani, M; Lakshmy, R; Luthra, K; Mansoori, N; Mukhopadhyay, AK; Sharma, S; Tripathi, M1
Bao, MS; Liao, YP; Liu, CQ; Meng, FM; Xiang, P; Zhang, D; Zhou, W1
Cao, H; Hu, H; Hu, X; Li, J; Liu, B; Liu, C; Shao, Y; Wang, J; Xin, S; Zhang, J; Zhang, Q; Zhang, Z1
Anello, G; Antonucci, I; Barone, C; Bosco, P; Coppedè, F; Denaro, M; Lorenzoni, V; Migliore, L; Romano, C; Stuppia, L1
Kumar, P; Mishra, OP; Rai, V; Yadav, SK; Yadav, U1
Cowen, PJ; Geddes, JR; Hockney, R; McPeake, L; Sharpley, AL1
Allen, GO; Franco, VI; Gong, F; Hu, JJ; Lee, E; Levine, EA; Zhang, Y1
Copp, AJ; Greene, ND1
Altug-Teber, Ö; Benedetti, JK; Blanke, CD; Holmes, RS; Lenz, HJ; Makar, KW; Rankin, C; Smalley, SR; Toriola, AT; Ulrich, CM1
Aben, KK; Anton-Culver, H; Antonenkova, N; Bandera, EV; Bean, Y; Beckmann, MW; Beesley, J; Berchuck, A; Bisogna, M; Bjorge, L; Bogdanova, N; Brinton, LA; Brooks-Wilson, A; Bruinsma, F; Butzow, R; Campbell, IG; Carty, K; Chang-Claude, J; Cook, LS; Cramer, DW; Cunningham, JM; Cybulski, C; Dansonka-Mieszkowska, A; Dicks, E; Doherty, JA; Dörk, T; du Bois, A; Dürst, M; Eccles, D; Edwards, RP; Ekici, AB; Engelholm, SA; Fasching, PA; Fridley, BL; Garcia-Closas, M; Gayther, SA; Gentry-Maharaj, A; Giles, GG; Glasspool, R; Goode, EL; Goodman, MT; Gronwald, J; Harter, P; Hein, A; Heitz, F; Hildebrandt, MA; Hillemanns, P; Høgdall, CK; Høgdall, E; Iversen, ES; Jakubowska, A; Jensen, A; Karlan, BY; Kelemen, LE; Kellar, M; Kelley, JL; Kiemeney, LA; Kjaer, SK; Krakstad, C; Kupryjanczyk, J; Lambrechts, D; Lambrechts, S; Le, ND; Leminen, A; Lester, J; Levine, DA; Liang, D; Lissowska, J; Lu, K; Lubiński, J; Lundvall, L; Lurie, G; Massuger, LF; McGuire, V; McLaughlin, JR; Menon, U; Modugno, F; Moysich, KB; Narod, SA; Ness, RB; Nevanlinna, H; Odunsi, K; Olson, SH; Orlow, I; Orsulic, S; Paul, J; Pearce, CL; Pejovic, T; Pelttari, LM; Pharoah, PD; Phelan, CM; Pike, MC; Plisiecka-Halasa, J; Poole, EM; Ramus, SJ; Risch, HA; Rossing, MA; Rothstein, JH; Rudolph, A; Runnebaum, IB; Salvesen, HB; Schildkraut, JM; Schwaab, I; Sellers, TA; Siddiqui, N; Sieh, W; Song, H; Southey, MC; Stram, D; Tangen, IL; Terry, KL; Thompson, PJ; Timorek, A; Tworoger, SS; Tyrer, JP; van Altena, AM; Van Nieuwenhuysen, E; Vergote, I; Vierkant, RA; Walsh, C; Wang, Q; Webb, PM; Weber, RP; Wentzensen, N; Whittemore, AS; Wilkens, LR; Wu, AH; Wu, X; Ziogas, A1
Choi, JU; Han, IB; Jeon, YJ; Kim, DS; Kim, HS; Kim, NK; Park, YS1
Jiang, C; Li, H; Song, T; Wang, Y; Wu, D; Yin, N; Zhao, Z1
Chang, CH; Chang, YH; Chien, SN; Chung, CJ; Hsieh, HA; Huang, CP; Liu, CS; Tsai, PH1
Angelini, S; Bermejo, JL; Biasco, G; Casali, PG; Consolini, N; Fumagalli, E; Hrelia, P; Musti, M; Nannini, M; Palassini, E; Pantaleo, MA; Ravegnini, G; Venturoli, N1
Ang, Y; Hau, C; Keld, R; Kumar, N; Sajid, J; Thian, M1
Spek, AA1
Keenan, E; Manne, SL; Myers, RE; Ross, E; Ruth, K; Sifri, R; Weinberg, DS; Ziring, B1
Chen, LP; He, JM; Pu, YD; Qin, R; Sun, YS; Wu, YJ; Zhang, QJ; Zheng, WW1
Armstrong, BK; Attia, J; Bailey, HD; Bower, C; Dawson, S; de Klerk, NH; Greenop, KR; Haber, M; Jamieson, SE; McCowage, GB; Miller, M; Milne, E; Norris, MD; Scott, RJ; van Bockxmeer, FM1
Rai, V1
Gupta, ED; Liew, SC1
de Camargo, B; Montalvão-de-Azevedo, R; Pombo-de-Oliveira, MS; Thuler, LC; Vargas, FR; Vasconcelos, GM1
Huang, X; Jiang, L; Li, H; Ni, W; Wu, A; Yang, H; Yang, X; Zhang, P1
Ambrosone, CB; Bandera, EV; Bovbjerg, DH; Ciupak, G; David Cheng, TY; Davis, W; Gong, Z; Jandorf, L; Khoury, T; Pawlish, K; Roberts, M; Yao, S; Zirpoli, G1
Gao, B; Ji, QH; Liu, XD; Liu, ZR; Ma, YY; Shi, M; Sun, D; Wang, B; Xu, X; Zhao, G1
Au, A; Camilleri, E; Gan, SH; Griffiths, LR; Haupt, LM; Sutherland, H; Wei, LK1
Debeljak, M; Dolžan, V; Erčulj, N; Faganel Kotnik, B; Goričar, K; Hovnik, T; Jazbec, J1
Karmadonova, NA; Karpenko, AA; Klevanets, JE; Kozyreva, VS; Shilova, AN; Subbotovskaya, AI1
Liu, J; Luo, Y; Sa, Y; Tang, W; Tang, X; Wu, X; Yang, K; Zhou, R1
Cabrera-Andrade, A; Echeverría, C; Herrera, C; López-Cortés, A; Oña-Cisneros, F; Ortiz, M; Paz-Y-Miño, C; Rosales, F; Sánchez, ME1
Armstrong, BK; Ashton, LJ; Attia, J; Bower, C; de Klerk, NH; Gottardo, NG; Greenop, KR; Haber, M; Jamieson, SE; Milne, E; Norris, MD; Scott, RJ; van Bockxmeer, FM1
Bozkurt, A; Kasapoglu, B; Kosar, A; Turkay, C; Yalcin, KS1
Huang, P; Lin, N; Liu, Y; Qin, Y; Shi, H; Sun, X; Wang, L; Yang, S; Yu, R; Zhang, Y1
Gupta, V; Jaiswal, SK; Kumar, A; Mishra, OP; Rai, AK; Raman, R; Sukla, KK1
Hwang, SG; Jang, HG; Jeon, YJ; Kim, JO; Kim, JW; Kim, NK; Kwon, SW; Oh, D; Oh, J; Park, HM1
Ágg, B; Benke, K; Harsányi, G; Mátyás, G; Maurovich-Horvat, P; Merkely, B; Nagy, ZB; Odler, B; Pólos, M; Radovits, T; Szabolcs, Z; Szilveszter, B; Szokolai, V1
Brasky, TM; Dumitrescu, RG; Freudenheim, JL; Kallakury, BV; Liu, Z; Llanos, AA; Makambi, KH; Marian, C; Mason, JB; Shields, PG; Spear, SL1
Bailey, LB; Beresford, SA; Brown, EC; Caudill, MA; Cheng, TY; Duggan, DJ; Galbraith, RL; Green, R; Habermann, N; Makar, KW; Maneval, DR; Miller, JW; Neuhouser, ML; Poole, EM; Song, X; Toriola, AT; Ulrich, CM; Zheng, Y1
Cho, SH; Jeon, YJ; Kim, JO; Kim, JW; Kim, NK; Ko, JJ; Oh, D; Oh, J; Yoo, JK1
Bazi, A; Garme, Y; Khosravi, A; Miri-Moghaddam, E; Motazedian, J; Saravani, S1
Dai, SX; Huang, JF; Li, WX; Lv, WW; Pan, ML1
Bao, Y; Guo, J; Lu, X; Wu, J; Wu, L; Yang, J; Zhang, T1
Holman, CD; Jin, J; Liu, P; Xie, X; Zhang, M1
Barua, S; Brown, WT; Junaid, MA; Kuizon, S1
Hua, L; Huang, Y; Li, J; Li, X; Liu, K; Shen, M; Wang, Z; Ye, J; Zhao, R1
Cha, DH; Jeon, YJ; Kim, IJ; Kim, JO; Kim, NK; Kim, OJ; Kim, SH; Lee, BE; Lim, SW; Moon, JY; Sung, JH1
Barlik, M; Kocięcka, M; Kurzawińska, G; Mrozikiewicz, AE; Wolski, H1
Bohn, T; Ströhle, A1
Ding, YP; Fredriksen, Å; Gregory, JF; Helgeland, Ø; Johansson, S; Meyer, K; Nygård, OK; Pedersen, EK; Svingen, GF; Ueland, PM1
Choi, IJ; Kim, J; Kim, W; Kim, YW; Lee, J; Sung, J; Woo, HD1
Ahani, A; Akbari, MT; Kamali, K; Saliminejad, K; Soleimani, E1
Alves, R; Baldeiras, I; Branco, CC; Carda, JP; Cortesão, E; Gonçalves, AC; Loureiro, L; Mota-Vieira, L; Nascimento Costa, JM; Oliveiros, B; Pereira, A; Sarmento-Ribeiro, AB1
Merle, BM; Rosner, B; Seddon, JM; Silver, RE1
Castanhole-Nunes, MM; Francisco, JL; Galbiatti-Dias, AL; Gimenez-Martins, AP; Goloni-Bertollo, EM; Maniglia, JV; Nascimento-Filho, CH; Padovani-Júnior, JA; Pavarino, EC; Zara-Lopes, T1
Dutta, P; Ghosh, K; Mahanta, J; Mirgal, D; Shetty, S1
Barrett, AN; Chen, ES; Choolani, MA; Jackson, RA; Nguyen, ML; Tan, YY1
Du, YF; Li, B; Lin, FY; Luo, WP; Mo, XF; Wang, L; Yan, B; Zhang, CX1
Jazbec, J; Karas-Kuzelicki, N; Mlinaric-Rascan, I; Smid, A1
Akbari, MR; Demsky, R; Eisen, A; Kim, SJ; Kim, YI; Kotsopoulos, J; Lubinski, J; Narod, SA; Sohn, KJ; Zuchniak, A1
Asrani, K; Lammer, EJ; Marini, NJ; Rine, J; Shaw, GM; Witte, JS; Yang, W1
Alrokayan, SA; Bharathi, V; Hussain, T; Krishna Prasad, C; Naik, U; Radha Rama Devi, A; Sai Shruti, P; Shaik Mohammad, N1
Amadou, A; Chajes, V; Clavel-Chapelon, F; Cox, DG; de Batlle, J; Fagherazzi, G; Matejcic, M; Moreno-Macias, H; Romieu, I; Slimani, N1
Ali, I; Bingham, V; Brazil, DP; Church, RH; Dunne, PD; Goldschmeding, R; Hombrebueno, JR; Kok, HM; Krishnakumar, A; Lavin, D; Martin, F; Tate, M1
Amaral, FM; Daldegan, MB; Grisolia, CK; Lordelo, GS; Miranda-Vilela, AL; Ribeiro, IF1
Duan, W; Li, Y; Lu, H; Qiao, B; Shi, KH; Tao, H; Wang, D; Wang, F; Wang, H; Zhao, JY; Zhao, R; Zhao, SM1
Andrews, D; Azad, A; Beheshti Zavareh, R; Birkan, R; Choo, C; Chow, V; Dhaliwal, S; Duda, V; Freedman, M; Garcia, A; Hicks, M; Kupferschmidt, AL; Lam, K; Lightman, D; Machalek, K; Mar, W; Moalem, S; Nguyen, F; Percy, M; Rytwinski, PJ; Schwarz, P; Somerville, MJ; Svara, E; Tran, M; Wheeler, K; Yeung, L; Zanibbi, K; Zener, R; Ziraldo, M1
Cheng, CH; Huang, MC; Huang, YC; Lee, BJ; Lin, PT; Tsai, TP1
Bartl, J; Bauer, P; Danielczyk, W; Fischer, P; Grünblatt, E; Jungwirth, S; Löffler, C; Rainer, MK; Riederer, P; Tragl, KH; Wichart, I; Zehetmayer, S1
Ananth, CV; Kinzler, WL; Leclerc, D; Moore, DF; Peltier, MR; Rozen, RR1
Brody, LC; Conley, MR; Cox, C; Doyle, A; Earley, M; Kirke, PN; Lynn, EC; McKiernan, E; Mills, JL; Molloy, AM; Orr, DJ; Pangilinan, F; Parle-McDermott, A; Scott, JM; Troendle, JF1
Smith, AD1
Chen, B; He, L; Li, F; Liao, PH; Qin, JM; Wang, XM; Yang, L1
Castilla, EE; Cooper, ME; Marazita, ML; Orioli, IM; Vieira, AR1
Blom, HJ; den Heijer, M; Heil, S; Kapusta, L; Mooij, C; van Beynum, IM1
Hamid, A; Kaur, J; Wani, NA1
Almeida, OP; Flicker, L; Hankey, GJ; Jamrozik, K; McCaul, K; Norman, P1
de Jonge, R; Hooijberg, JH; Jansen, G; Kaspers, GJ; Lindemans, J; Peters, GJ; Pieters, R; Tissing, WJ1
Cao, J; Hanson, NQ; Kim, Y; Loria, CM; Schreiner, PJ; Siscovick, D; Tsai, MY1
Gray, JD; Ross, ME1
Bonomo, A; Corrêa, JC; Fintelman-Rodrigues, N; Moura, KC; Pimentel, MM; Rodrigues, CS; Santos, JM; Santos-Rebouças, CB1
Liu, J; Pei, L; Ren, A; Zhang, Y; Zhu, H1
Deng, L; Lawrance, AK; Rozen, R1
Brody, LC; Kirke, PN; Mills, JL; Molloy, AM; Scott, JM1
Demirhan, O; Sertdemir, Y; Tastemir, D1
Kuo, CS; Lin, CY; Lu, CL; Syu Huang, RF; Wu, MY1
Blum, K; Meshkin, B1
Carvalho, SM; Hamada, GS; Iwasaki, M; Junko, I; Laginha, FM; Ma, E; Motola, J; Nishimoto, IN; Tsugane, S1
Akella, RR; Chintakindi, KP; Jain, JM; Mohammad, NS; Naik, U; Singh, RP1
Kim, YI2
Finnell, RH; Kartiko, S; Zhu, H1
Barcellos, LF; Briggs, FB; Carmichael, SL; Finnell, RH; Lammer, EJ; Lu, W; Shaw, GM; Yang, W; Zhu, H1
Agrawal, S; Baburaj, VP; Sankhwar, SN; Sharma, RK; Tripathi, G1
Copp, AJ; Doudney, K; Greene, ND; Grinham, J; Lynch, SA; Moore, GE; Stanier, P; Thompson, D; Whittaker, J1
Hiraoka, M; Kagawa, Y; Kageyama, M1
Ambrosio, C; Catozzi, L; Cuneo, A; De Mattei, M; Della Porta, M; Friso, S; Gemmati, D; Krampera, M; Ongaro, A; Orioli, E; Serino, ML; Zeri, G1
Cao, HX; Ding, JH; Gao, CM; Li, SP; Liu, YT; Matsuo, K; Su, P; Tajima, K; Takezaki, T; Tang, JH; Wang, J; Wu, JZ1
Chen, J; Chihu-Amparan, L; Flores-Luna, L; Galván-Portillo, MV; Herrera-Goepfert, R; López-Carrillo, L; Mohar-Betancourt, A; Oñate-Ocaña, LF; Pérez-Pérez, GI1
Alfirevic, A; Carr, DF; Pirmohamed, M; Whiteley, G1
Alonso-Arranz, A; Bravo, Y; Castillo, J; Oterino, A; Pascual, J; Quintela, E; Ruiz-Alegria, C; Toriello, M; Valle, N1
Gajecka, M; Jagodziński, PP; Kruszyna, Ł; Lianeri, M; Rydzanicz, M; Szyfter, K1
Boreham, CA; Buckley, PT; Kealey, C; McNulty, H; Mitchell, LE; Murray, L; Scott, JM; Stanisławska-Sachadyn, A; Strain, JJ; Whitehead, AS; Woodside, JV; Young, IS1
Davey Smith, G; Leary, S; Lewis, SJ; Ness, A1
Goodman, MT; Henderson, BE; Kolonel, LN; Le Marchand, L; Murphy, SP; Nomura, AM; Selhub, JS; Tiirikainen, M; White, KK; Wilkens, LR1
Au, KS; Fletcher, JM; Lin, JI; Martinez, CA; Morrison, AC; Northrup, H; Tyerman, GH1
Kaplan, BJ; Leung, BM1
Al Olama, AA; Benediktsdottir, KR; Chen, L; Collin, SM; Cox, A; Davis, M; Donovan, J; Easton, DF; Eeles, RA; Gudmundsson, J; Guy, M; Hamdy, FC; Kote-Jarai, Z; Lane, JA; Lewis, SJ; Martin, RM; Metcalfe, C; Morrison, J; Neal, DE; Rafnar, T; Smith, GD; Stefansson, K; Sulem, P; Zuccolo, L1
Dziegelewska, M; Hozyasz, KK; Jagodzinski, PP; Mostowska, A; Wojcicki, P1
Hermans, FJ; Kaspers, GJ; Koppen, IJ1
Butler, LM; Galanko, J; Keku, T; Massa, B; Millikan, RC; Sandler, RS; Steck, SE1
Blades, B; Boyd, L; Dufficy, L; Lewis, P; Lucock, M; Naumovski, N; Ng, X; Roach, P; Sturm, J; Townley-Jones, M; Travers, C; Veysey, M; Yates, Z1
Garbarini, J; Goldmuntz, E; Long, J; Mitchell, LE; Paluru, P1
Burren, KA; Copp, AJ; Greene, ND; Scott, JM1
Duan, ZQ; Fan, YY; He, JA; Hu, XH; Liu, CW; Xin, SJ; Yang, DH; Yang, J; Zhang, J; Zhang, Q; Zhang, ZS1
Steegers, EA; Steegers-Theunissen, RP; Uitterlinden, AG; van Meurs, J; van Rooij, IA; Vujkovic, M; Yazdanpanah, N1
Barlik, M; Drews, K; Kurzawińska, G; Mrozikiewicz, PM; Seremak-Mrozikiewicz, A1
Cullman, I; Dahlin, AM; Eklöf, V; Hallmans, G; Henriksson, ML; Hultdin, J; Johansson, I; Palmqvist, R; Van Guelpen, B1
Fan, H; Jing, XA; Li, D; Wang, HY; Ye, WJ1
Jupe, ER; Maruti, SS; Ulrich, CM; White, E1
Goldmuntz, E; Lupo, PJ; Mitchell, LE; Renstrom, D; Woyciechowski, S1
Baron, JA; Campbell, PT; Conti, DV; Duggan, D; Figueiredo, JC; Haile, RW; Hopper, J; Jenkins, MA; Le Marchand, L; Lee, WH; Levine, AJ; Lewinger, JP; Limburg, PJ; Martinez, ME; Newcomb, P; Potter, J; Poynter, JN; Ulrich, CM1
Hernán, MA; Hernández-Díaz, S; VanderWeele, TJ1
Devi, AR; Naushad, SM1
Baron, JA; Campbell, PT; Conti, D; Duggan, DJ; Figueiredo, JC; Haile, RW; Hopper, JL; Le Marchand, L; Lee, W; Levine, AJ; Limburg, PJ; Martinez, ME; Newcomb, P; Poynter, JN; Ulrich, CM1
Goldmuntz, E; Lupo, PJ; Mitchell, LE2
Khuhaprema, T; Ohnami, S; Sakamoto, H; Sangrajrang, S; Sato, Y; Yoshida, T1
Blinov, MN; Kapustin, SI; Klenkova, NA; Saltykova, NB; Shmeleva, VM1
Alam, MT; Huq, S; Pietroni, MA; Rahman, H1
Eden, T1
Kleĭmenova, EB; Konstantinova, MV; Nazarenko, GI; Skvortsova, VI1
Guenther, M; Hebart, H; Herrlinger, U; Knop, S; Korfel, A; Kurzwelly, D; Linnebank, M; Loeffler, J; Simon, M; Thiel, E; Weller, M1
Hu, J; Wang, N; Wang, YJ; Zhou, GW1
Hasdai, D; Iakobishvili, Z; Kaluski, DN; Lev, E; Mager, A; Messika, AH; Shohat, M1
Ardanaz, E; Berrino, F; Bingham, S; Boffetta, P; Boutron-Ruault, MC; Bueno-de-Mesquita, HB; Clavel-Chapelon, F; Dorronsoro, M; Ericson, U; Eussen, SJ; Fredriksen, A; González, CA; Gram, IT; Igland, J; Jenab, M; Kaaks, R; Katsoulis, M; Khaw, KT; Linseisen, J; Lund, E; Manjer, J; Martínez, C; Meyer, K; Morois, S; Navarro, C; Norat, T; Olsen, A; Overvad, K; Palli, D; Palmqvist, R; Panico, S; Peeters, PH; Pischon, T; Riboli, E; Rodríguez, L; Skeie, G; Slimani, N; Tjønneland, A; Trichopoulou, A; Tumino, R; Ueland, PM; van Duijnhoven, FJ; Van Guelpen, B; Vineis, P; Vollset, SE; Weikert, C; Zilis, D1
Fenger, M; Gilderson, G; Husemoen, LL; Jørgensen, T; Linneberg, A; Ovesen, L; Thuesen, BH1
Cho, YJ; Lee, EJ; Yoon, YJ1
Safarinejad, MR; Safarinejad, S; Shafiei, N1
Anton-Culver, H; Beesley, J; Berchuck, A; Brar, S; Carney, ME; Chang-Claude, J; Chenevix-Trench, G; Cramer, DW; Cunningham, JM; Dicioccio, RA; Doherty, JA; Easton, DF; Fredericksen, ZS; Fridley, BL; Gates, MA; Gayther, SA; Gentry-Maharaj, A; Goode, EL; Goodman, MT; Høgdall, E; Kelemen, LE; Kjaer, SK; Köbel, M; Lurie, G; McGuire, V; Menon, U; Moorman, PG; Moysich, K; Ness, RB; Palmieri, RT; Pearce, CL; Pharoah, PD; Ramus, SJ; Rossing, MA; Schildkraut, JM; Sellers, TA; Song, H; Stram, DO; Tworoger, SS; Van Den Berg, D; Vierkant, RA; Wang-Gohrke, S; Webb, PM; Whittemore, AS; Wilkens, LR; Wu, AH1
Buyukbas, S; Cosar, E; Erdogan, MO; Eser, B; Eser, O; Koken, R; Solak, M; Yildiz, SH1
Chen, Z; Ge, L; Huang, S; Jiang, T; Jiang, Y; Lei, Y; Xia, B; Zhao, J; Zhou, F1
Baron, JA; Campbell, PT; Conti, DV; Duggan, DJ; Figueiredo, JC; Haile, RW; Hopper, JL; Kennedy, K; Le Marchand, L; Lee, W; Levine, AJ; Limburg, PJ; Martinez, ME; Newcomb, P; Poynter, JN; Ulrich, CM1
Aggio, S; Chinaglia, M; Grassetto, G; L'Erario, R; Mazza, A; Montemurro, D; Pastore, G; Piergentili, C; Rubello, D; Zamboni, S; Zanier, A; Zanon, F1
Erickson, RP1
Chan, JY; Lu, Y; Lum, DW; Ugrasena, DG; Yeoh, AE1
Brunel-Guitton, C; Costa, T; Lambert, M; Mitchell, GA1
Cortes, A; El-Zein, RA; Etzel, CJ; Greisinger, AJ; Lopez, MS; Monroy, C; Piskac-Collier, AL; Spitz, MR1
Collin, SM; Cox, A; Davis, M; Donovan, JL; Hamdy, FC; Johnston, C; Lane, JA; Lewis, SJ; Marsden, G; Martin, RM; Metcalfe, C; Neal, DE; Refsum, H; Smith, AD; Smith, GD1
Amouyel, P; Bokor, S; Dallongeville, J; Gonzalez-Gross, M; Meirhaeghe, A; Molnàr, D; Moreno, LA; Ruiz, JR; Widhalm, K; Zaccaria, M1
Bufalino, A; Coletta, RD; Martelli-Júnior, H; Nascimento de Aquino, S; Oliveira Swerts, MS; Ribeiro Paranaíba, LM1
Chen, AR; Fu, SJ; Hu, XJ; Ning, YY; Ren, JG; Tian, LH; Wang, ZP; Yang, PQ; Zhang, HG1
de Bruïne, AP; de Goeij, AF; de Vogel, S; Goldbohm, RA; Gottschalk, RW; van den Brandt, PA; van Engeland, M; van Schooten, FJ; Weijenberg, MP; Wouters, KA1
Choi, SW; Friso, S; Kim, MK; Lee, JK; Lee, JM; Lee, JP; Lee, KB; Song, ES; Tong, SY1
Chen, GK; Thomas, DC1
Choi, YK; Chong, SY; Kim, JW; Kim, NK; Oh, D; Park, HM1
Digumarti, RR; Gottumukkala, SR; Kutala, VK; Naushad, SM; Pavani, A1
Isaacs, A; Obermann-Borst, SA; Steegers, EA; Steegers-Theunissen, RP; van der Heiden, IP; van Duyn, CM; van Schaik, RH; Younes, Z1
Blanton, SH; Burt, A; Chiquet, BT; Hecht, JT; Henry, R; Mulliken, JB; Stal, S1
Blanton, SH; Finnell, RH; Hecht, JT; Henry, RR; Mulliken, JB; Stal, S; Yuan, Q1
Conti, DV; Davis, BD; Edlund, CK; Figueiredo, JC; Haile, RW; Heber, D; Henning, SM; Lee, W; Levine, AJ; Stern, MC; Vandenberg, DJ1
Cleves, MA; Hobbs, CA; Krakowiak, PA; MacLeod, SL; Zhao, W1
Crott, JW; Huang, T; Lai, CQ; Lee, YC; Li, D; Ordovas, JM; Parnell, LD; Shen, J; Smith, CE; Tucker, KL1
Chebil, M; Cherif, M; Elgaaied, AB; Marrakchi, R; Ouerhani, S; Rouissi, K; Sfaxi, M; Slama, MR; Stambouli, N1
Božo, L; Brčić-Kostić, K; Catela Ivković, T; Gamulin, M; Jokić, M; Kapitanović, S; Stefulj, J1
Hanai, N; Hasegawa, Y; Hosono, S; Ito, H; Kawakita, D; Matsuo, K; Murakami, S; Oze, I; Sato, F; Tajima, K; Tanaka, H; Watanabe, M; Yatabe, Y1
Caan, BJ; Curtin, K; Herrick, JS; Samowitz, WS; Slattery, ML; Ulrich, CM; Wolff, RK1
Chitlur, M; Lusher, J; Nahar, A; Rajpurkar, M; Ravindranath, Y; Sabo, C1
Liang, S; Ren, YY1
Ahmadi, KR; Andrew, T; Clement, G; Cotlarciuc, I; Dew, T; Gill, R; Sherwood, R; Surdulescu, G1
Liu, L; Ma, X; Mi, Y; Qiu, L; Wang, J; Xiao, Z; Yang, L1
Bertollo, EM; Biselli, JM; Carvalho, VM; Eberlin, MN; Haddad, R; Marucci, GH; Pavarino, EC; Riccio, MF; Valentin, S; Vannucchi, H; Zampieri, BL1
Lesiak, A; Narbutt, J; Norval, M; Pawliczak, R; Rogowski-Tylman, M; Sobjanek, M; Sysa-Jedrzejowska, A; Wlodarkiewicz, A; Wodz-Naskiewicz, K1
Aldrich, MC; Barcellos, LF; Block, G; Buffler, PA; Chang, JS; Chokkalingam, AP; Guha, N; Hansen, HM; Kiley, V; Metayer, C; Scélo, G; Urayama, KY; Wiemels, JL; Wiencke, JK1
Chandak, GR; Gayathri, P; Ghule, S; Godbole, K; Kanitkar-Damle, A; Memane, N; Sasirekha, BV; Sheth, J; Suresh, S; Yajnik, CS1
Barbosa, CP; Bianco, B; Christofolini, DM; Gava, MM; Glina, S; Kayaki, EA; Pompeo, AC; Teles, JS1
Arora, J; Deb, R; Gupta, S; Kalla, AK; Meitei, SY; Saran, S; Saraswathy, KN; Verma, V1
Ahn, SH; Kang, D; Lee, KM; Lee, SA; Noh, DY; Yoo, KY1
Gokcen, C; Kocak, N; Pekgor, A1
Hasegawa, Y; Hosono, S; Ito, H; La Vecchia, C; Matsuo, K; Negri, E; Oze, I; Rossi, M; Tajima, K; Tanaka, H; Watanabe, M; Yatabe, Y1
Aktas, B; Alkış, N; Coban, S; Ekiz, F; Karabulut, HG; Ormeci, N; Tukun, A; Tuncali, T; Yüksel, O1
Choi, JS; Cui, LH; Kim, HN; Shen, F; Shin, MH; Si, H; Song, Y1
Goldmuntz, E; Long, J; Lupo, PJ; Mitchell, LE1
Cabelof, DC; Patterson, D1
Brohawn, DG; Goff, DC; Macklin, EA; Nitenson, AZ; Roffman, JL; Smoller, JW1
Asomaning, K; Christiani, DC; Lee, MS; Mark, EJ; Su, L; Wain, JC1
Brody, LC; Browne, ML; Caggana, M; Carter, TC; Druschel, CM; Kay, DM; Liu, A; Mills, JL; Romitti, PA1
Alencar, VH; Carvalho Barbosa, Rde C; Freire, TF; Menezes, DC; Rabenhorst, SH; Sales, DC1
Carmichael, SL; Gilbert, DA; Hardin, J; Hoffmann, TJ; Lammer, EJ; Lazaruk, K; Lipzen, A; Marini, NJ; Pennacchio, LA; Rine, J; Shaw, GM; Stein, JB; Witte, JS; Wright, C1
McNulty, H; Pentieva, K; Strain, JJ; Ward, M1
Jagodzinski, PP; Kędzia, H; Lianeri, M; Mostowska, A; Pawlik, P; Sajdak, S1
Chen, QY; Hui, LL; Li, H; Long, LL; Shen, HL; Xu, WL; Zhu, XL1
Coppedè, F1
Boyarskikh, UA; Filipenko, ML; Lazarev, AF; Petrova, VD; Selezneva, IA; Sinkina, TV; Voronina, EN; Weiner, AS1
Li, Z; Lin, B; Lin, F; Lin, J; Luo, R; Zhao, P1
Akadam-Teker, AB; İsbir, T; Küçükhüseyin, Ö; Kurnaz, Ö; Narter, F; Yılmaz-Aydoğan, H1
Addlagatta, A; Digumarti, RR; Divyya, S; Gottumukkala, SR; Kumar, A; Kutala, VK; Murthy, PV; Naushad, SM; Rammurti, S; Reddy, ChR1
Lele, SS; Singh, PR1
Cha, SH; Choi, DH; Choi, Y; Choi, YS; Jeon, YJ; Kim, NK; Ko, JJ; Rah, H; Shim, SH1
Fuchs, CS; Giovannucci, E; Hunter, DJ; Lee, IM; Lee, JE; Ma, J; Selhub, J; Stampfer, MJ; Wei, EK; Willett, WC1
Andelfinger, GU; Bigras, JL; Christensen, KE; Dubé, MP; Michaud, JL; Richter, A; Rohlicek, CV; Rozen, R; Zada, YF1
Hamada, A; Mori, H; Mori, M; Taguchi, T; Yamori, Y1
Jayaprakash, PG; Lalitha, P; Pillai, MR; Ragasudha, PN; Thulaseedharan, JV; Wesley, R1
Furst, J; Glanville, T; Lucock, M; Simpson, N; Walker, J; Yates, Z1
Cassano, PA; Clark, AG; Gaziano, JM; Litonjua, AA; Stover, PJ; Tucker, KL; Vokonas, PS; Weiss, ST; Wells, MT; Wernimont, SM1
Arenas-Aranda, D; Balderrábano-Saucedo, NA; Bravo-Hernández, G; García-Hernández, N; Klunder-Klunder, M; Noriega-Zapata, P; Sánchez-Boiso, A; Sánchez-Urbina, R; Sierra-Ramírez, JA; Vizcaíno-Alarcón, A1
Zohn, IE1
Amigou, A; Baruchel, A; Bertrand, Y; Chastagner, P; Clavel, J; Ducassou, S; Goujon-Bellec, S; Haouy, S; Hémon, D; Leverger, G; Michel, G; Nelken, B; Orsi, L; Plat, G; Rialland, X; Rudant, J1
Martinelli, M; Mattei, G; Montroni, I; Rosati, G; Scapoli, L; Solmi, R; Ugolini, G; Zattoni, D1
Artuch, R; Montoya, J; Ormazabal, A; Pérez-Dueñas, B; Serrano, M1
Brody, LC; Chines, P; Conley, M; Cornman-Homonoff, J; Geiler-Samerotte, K; Kirke, PN; Krebs, KM; Mills, JL; Mitchell, A; Molloy, AM; O'Leary, VB; Pangilinan, F; Parle-McDermott, A; Sanchez, A; Scott, JM; Seay, JM; Shane, B; Signore, C; Stone, N; Troendle, JF; VanderMeer, JE1
Białecka, M; Budrewicz, S; Droździk, M; Gorzkowska, A; Gołąb-Janowska, M; Honczarenko, K; Jarosz, M; Koziorowska-Gawron, E; Kurzawski, M; Mak, M; Robowski, P; Roszmann, A; Sitek, EJ; Sławek, J1
Carmichael, SL; Etheredge, AJ; Finnell, RH; Lammer, EJ; Mitchell, LE; Shaw, GM; Zhu, H1
Kamdar, KY; Lupo, PJ; Nousome, D; Okcu, MF; Scheurer, ME1
Iwasaki, M; Kasuga, Y; Kuchiba, A; Kusama, R; Nishimura, H; Ohnami, S; Ono, H; Onuma, H; Sakamoto, H; Tsugane, S; Yokoyama, S; Yoshida, T1
Caan, BJ; Curtin, K; Liu, AY; Makar, K; Poole, E; Potter, JD; Scherer, D; Slattery, ML; Ulrich, CM1
Diakite, B; Hamzi, K; Jouhadi, H; Nadifi, S; Tazzite, A1
Carbonara, P; Farinella, F; Fasano, L; Girardi, A; Martinelli, M; Mattei, G; Nava, S; Pacilli, AM; Scapoli, L; Solmi, R; Valentini, I1
Chen, Y; Wang, BJ1
Jeon, YJ; Kim, NK; Kim, OJ; Kim, SY; Oh, D; Oh, SH; Shin, BS1
Au, KS; Cirino, PT; Dennis, M; Fletcher, JM; Martinez, CA; Morrison, AC; Northrup, H; Spellicy, CJ1
Ashley-Koch, AE; Garrett, ME; Jamerson, BD; Payne, ME; Speer, MC; Steffens, DC1
Babyshkina, N; Cherdyntseva, N; Gervas, P; Koval, M; Malinovskaya, E; Nazarenko, M; Potapova, O; Slonimskaya, E1
Forman, MR; Hernandez, LM; Lupo, PJ; Peterson, CB; Shete, S; Spitz, MR; Swartz, MD; Vannucci, M; Wu, X1
Baurley, J; Crott, JW; Figueiredo, JC; Haile, RW; Levine, AJ1
Braune, A; Grunert, RR; Krause, HR; Schloot, W; Schnackenberg, E1
Giovannucci, E1
Finnell, RH; Lammer, EJ; Shaw, GM; Volcik, KA1
Grzeszczak, W; Gumprecht, J; Zukowska-Szczechowska, E; Zychma, MJ1
Blom, HJ; Boers, GH; den Heijer, M; Kluijtmans, LA; Lievers, KJ; Trijbels, FJ; Verhoef, P1
Bendlová, B; Hrach, K; Hyánek, J; Kahleová, R; Kozich, V; Nováková, I; Palyzová, D; Zvára, K; Zvárová, J1
Ankathil, R; Krishnan Nair, M; Kusumakumary, P; Priyakumary, T1
James, WP1
Emi, N; Hamajima, N; Hishida, A; Ito, H; Kagami, Y; Matsuo, K; Morishima, Y; Ogura, M; Taji, H; Tajima, K1
Agorastos, T; Bontis, J; Chrisafi, S; Constantinidis, TC; Foka, ZJ; Kotsis, A; Lambropoulos, AF1
Boreham, CA; Kluijtmans, LA; McMaster, D; McNulty, H; McPartlin, J; Murray, L; Scott, JM; Strain, JJ; Whitehead, AS; Young, IS1
Boer, JM; Cornelisse, CJ; Feskens, EJ; Heijmans, BT; Kromhout, D; Slagboom, PE; Suchiman, HE; Westendorp, RG1
Bott, C; Lembcke, B; Stein, J1
Boreham, CA; Brown, KS; Evans, AE; Kluijtmans, LA; McMaster, D; McNulty, H; Mitchell, LE; Murray, L; Strain, JJ; Whitehead, AS; Woodside, J; Yarnell, JW; Young, IS1
Fallon, UB1
Al-Ghnaniem, R; Appleby, P; Emery, PW; Gout, S; Leather, AJ; Pufulete, M; Sanders, TA; Terry, C1
Finnell, RH; Gould, A; Spiegelstein, O1
Abyholm, FE; Drevon, CA; Jugessur, A; Lie, RT; Murray, JC; Taylor, JA; Ulvik, A; Vindenes, HA; Wilcox, AJ1
Finnell, RH; Lammer, EJ; Shaw, GM; Volcik, KA; Zhu, H1
Lucock, M; Yates, Z1
Blom, HJ; den Heijer, M; Klerk, M; Kluijtmans, LA; Kok, FJ; Lievers, KJ; Schouten, EG; Verhoef, P1
Anello, G; Barone, C; Bosco, P; Caraci, F; Guéant, JL; Guéant-Rodriguez, RM; Namour, F; Romano, A; Romano, C1
Braun, S; Burghartz, M; Kastrati, A; Koch, W; Kölling, K; Lengnick, H; Mehilli, J; Ndrepepa, G; Schömig, A1
Cheschier, N1
Qiu, L; Song, YH; Yan, SK1
Kumar, R; Mihalick, SM; Ortiz, D; Rogers, E; Shea, TB1
Cai, Q; Dai, Q; Gao, YT; Hébert, JR; Jin, F; Shrubsole, MJ; Shu, XO; Zheng, W1
Little, J; Sharp, L1
Hiraoka, M; Kagawa, Y; Kato, K; Saito, Y; Yasuda, K1
Burn, J; Jonas, PA; Laffling, AJ; Lynch, SA; Pearce, MS; Relton, CL; Tawn, EJ; Wilding, CS1
De Vivo, I; Han, J; Hankinson, SE; Hunter, DJ; Zhang, SM1
Cheng, J; Dao, J; Zhao, R; Zhu, W1
Gorlov, IP; Grossman, HB; Hernandez, LM; Lin, J; Pillow, PC; Schabath, MB; Spitz, MR; Wang, Y; Wu, X1
Boreham, CA; Brown, KS; Kluijtmans, LA; McMaster, D; McNulty, H; McPartlin, J; Mitchell, LE; Murray, L; Scott, JM; Strain, JJ; Whitehead, AS; Woodside, JV; Yarnell, JW; Young, IS1
Fliessbach, K; Glasmacher, A; Heun, R; Klockgether, T; Kölsch, H; Linnebank, A; Linnebank, M; Pels, H; Schlegel, U; Schmidt, S; Schmidt-Wolf, IG1
De Vivo, I; Hankinson, SE; Hunter, DJ; Paynter, RA1
SoRelle, R1
Hao, L; Hou, GW; Jiang, YY; Li, Z; Pan, YJ; Pei, LJ; Ren, AG; Wu, LM; Zhang, BL; Zhang, ML; Zhao, WR; Zhu, HP1
Bazul, V; Sanchez, SE; Williams, MA; Zhang, C1
Chen, K; Jin, MJ1
Andel, M; Hyánek, J; Janosíková, B; Kozich, V; Pavlíková, M; Veselá, K; Zvárová, J1
Li, Z; Pei, LJ1
Guilhem, S; Igor, S; Isabelle, RV1
Britton, JA; Chan, W; Chen, J; Gammon, MD; Kabat, GC; Neugut, AI; Palomeque, C; Santella, RM; Teitelbaum, SL; Terry, MB; Wetmur, JG1
Farmand, S; Fliessbach, K; Kleczar, N; Klockgether, T; Linnebank, M; Orlopp, K; Pels, H; Schlegel, U; Schmidt-Wolf, IG; Urbach, H1
Borderie, D; Deschênes, G; Favier, R; Frémeaux-Bacchi, V; Giraudier, S; Guigonis, V; Massy, Z; Mougenot, B; Rosenblatt, DS1
Bacino, CA; Blau, N; Bottiglieri, T; Curry, S; del Gaudio, D; Finnell, RH; Hyland, K; Miller, G; Moretti, P; Neul, JL; Peters, S; Ramaekers, VT; Roa, B; Sahoo, T; Scaglia, F; Zhu, H1
Festa, F; Försti, A; Hemminki, K; Kumar, R; Lindholm, B; Nordfors, L; Sanyal, S; Schalling, M; Snellman, E; Undén, B1
Berndt, SI; Caporaso, N; Chanock, S; He, X; Lan, Q; Rothman, N; Shen, M; Welch, R; Yeager, M1
Cronin, S; Furie, KL; Kelly, PJ1
Li, Z; Li, ZW; Pei, LJ; Ren, AG; Zhang, W; Zhu, HP; Zhu, JH1
Bravo, Y; Castillo, J; Cid, C; Leyva-Cobián, F; Muñoz, P; Oterino, A; Pascual, J; Ruiz-Alegría, C; Sánchez-Velasco, P; Valle, N1
Finnell, RH; Li, Z; Pei, L; Ren, A; Zhu, H; Zhu, J1
Alvarez González, A; Delgado, P; Hernández, D; Lorenzo, V; Pérez Tamajón, L; Sánchez Alvarez, JE1
Chen, K; Kono, S1
Ashok, TD; Badovinac, R; Hayes, C; Hernández-Díaz, S; Kelsey, KT; Mitchell, AA; Werler, MM; Wu, XF1
Bartram, C; Burwinkel, B; Flohr, T; Gast, A; Hemminki, K; Kumar, R; Thirumaran, RK1
Bukowska, H; Honczarenko, K; Jastrzebska, M; Mierzecki, A; Millo, B; Torbus-Lisiecka, B1
da Costa, KA; Fischer, LM; Kohlmeier, M; Zeisel, SH1
Ulrich, CM1
Finnell, RH; Lammer, EJ; Lu, W; Shaw, GM; Yang, W; Zhang, J; Zhu, H1
Bowron, A; Scott, J; Stansbie, D1
Adjalla, CE; Candito, M; Gibelin, P; Gueánt, JL; Guéant-Rodriguez, RM; Herbeth, B; Juilliére, Y; Van Obberghen, E1
Bigler, J; Caan, B; Curtin, K; Potter, JD; Slattery, ML; Ulrich, CM1
Chen, J; Galván-Portillo, M; Lacasaña-Navarro, M; López-Carrillo, L; López-Cervantes, M1
Lacassie, HJ; Mellado, P; Muir, HA; Nazar, C; Sandoval, P; Yonish, B1
Chan, JB; Chen, CP; Eikelboom, JW; Hankey, GJ; Ho, GY; Tan, SL; Wong, CR1
Araya, R; Davey Smith, G; Day, IN; Ebrahim, S; Lawlor, DA; Lewis, SJ; Timpson, N1
Baudry-Bluteau, D; Besson, C; Brousse, N; Junien, C; Landais, P; Macintyre, E; Niclot, S; Pruvot, Q; Salles, G; Savoy, D; Taupin, P; Varet, B1
Birk, Y; Morgenstern, S; Niv, Y; Rosman-Urbach, M; Schwartz, B1
Anteunis, LJ; Bots, ML; Durga, J; Kok, FJ; Schouten, EG; Verhoef, P1
Baciliero, U; Carinci, F; Carinci, P; Martinelli, M; Morselli, PG; Padula, E; Palmieri, A; Pezzetti, F; Scapoli, L1
Anello, G; Bosco, P; Ferri, R; Guéant, JL; Guéant-Rodriguez, RM1
Nurk, E; Refsum, H; Tell, GS; Ueland, PM; Vollset, SE1
Amato, S; Bottini, F; Calevo, MG; Celle, ME; Cerone, R; Di Pasquale, D; Minniti, G; Molinari, AC; Montaldi, L; Veneselli, E1
Badaloo, AV; Farrall, M; Forrester, T; Howell, S; Marshall, KG; McKenzie, CA; Reid, M1
Chen, F; Chen, W; Gao, J; Hu, Z; Jin, G; Liu, J; Qin, J; Shen, H; Tang, J; Wang, S; Wang, X; Wei, Q; Zhai, X1
Padmanabhan, R1
Chou, YC; Lee, MS; Shih, HL; Sun, CA; Wu, MH; Wu, TY; Yang, T; Yu, JC1
Aziz, M; Habib, EE; Kotb, M1
Cha, KY; Jeong, YM; Kim, NK; Lee, HC; Lee, KW; Lee, S; Lee, SH; Song, SH1
Blom, HJ; den Heijer, M; Finnell, RH; Shaw, GM1
Cho, SE; Chung, WS; Hong, KS; Shin, GJ1
Krajinovic, M; Labuda, D; N'Diaye, N; Sinnett, D1
Brenner, B; Hoffman, R; Nadir, Y1
Chanock, SJ; Engel, SM; Olshan, AF; Savitz, DA; Siega-Riz, AM1
Anthony, TE; Heintz, N1
Beaumont, H; Corder, EH1
Linnebank, M; Moskau, S; Semmler, A; Simon, M1
Boisson, C; Candito, M; Gaucherand, P; Guéant, JL; Luton, D; Naimi, M; Rudigoz, JC; Van Obberghen, E1
Finnell, RH; Harris, JA; Jelliffe-Pawlowski, L; Nelson, V; Shaw, GM; Zhu, H1
Gasche, C; Kulnigg, S1
Dierkes, J; Ebert, MP; Götze, T; Hoffmann, J; Malfertheiner, P; Röcken, C; Röhl, FW; Westphal, S; Wex, T1
Bahuau, M; Chevrier, C; Cordier, S; Finnell, RH; Francannet, C; Herman, C; Nelva, A; Perret, C; Robert-Gnansia, E; Zhu, H1
Chanock, S; Chen, J; Chow, WH; Hou, L; Lissowska, J; Morabia, A; Terry, MB; Yeager, M; Zatonski, W; Zhang, FF1
Caan, BJ; Curtin, K; Holubkov, R; Murtaugh, MA; Slattery, ML; Sweeney, C; Wolff, RK1
Alfthan, G; Erlund, I; Happonen, P; Kaplan, GA; Kauhanen, J; Korhonen, M; Mosher, MJ; Mursu, J; North, KE; Salonen, JT; Tiihonen, J; Tuomainen, TP; Virtanen, JK; Voutilainen, S1
Dhillon, VS; Husain, SA; Shahid, M1
Kampman, E; Keijer, J; Kok, FJ; Pellis, L; van den Donk, M; van Engeland, M; Witteman, BJ1
Jain, S; Khullar, M; Kumari, S; Markan, S; Sachdeva, M; Sehrawat, BS1
Chandler, I; Houlston, RS; Hubner, RA; Lubbe, S1
Bencko, V; Boffetta, P; Brennan, P; Canzian, F; Chabrier, A; Fabianova, E; Foretova, L; Gaborieau, V; Hall, J; Hashibe, M; Hung, RJ; Janout, V; Lissowska, J; Mates, I; McKay, J; Moullan, N; Rudnai, P; Szeszenia-Dabrowska, N; Zaridze, D1
Blom, HJ; den Heijer, M; Gellekink, H1
Garanty-Bogacka, B; Gebala, A; Goral, J; Krupa, B; Syrenicz, M; Szołomicka-Kurzawa, P1
Hida, T; Hiraki, A; Matsuo, K; Mitsudomi, T; Saito, T; Sato, S; Suzuki, T; Tajima, K; Ueda, R; Yatabe, Y1
Choi, JS; Jo, DY; Kim, HJ; Kim, HN; Kim, YK; Lee, IK; Lee, JJ; Park, KS; Park, MR; Yang, DH1
Hasegawa, Y; Hiraki, A; Hirose, K; Matsuo, K; Saito, T; Sato, S; Suzuki, T; Tajima, K; Ueda, R; Wakai, K1
Alonso, E; Arauz, A; Cantú, C; Fernández, Mde L; García, I; Hoyos, L; Jara, A; Martínez, L1
Chayama, K; Hiyama, T; Tanaka, S; Yoshihara, M1
Ananth, CV; De Marco, C; Elsasser, DA; Getahun, D; Peltier, MR; Rozen, R; Smulian, JC1
Wang, W; Wang, Xy; Xie, W1
Caballero, J; Carnero, J; Diaz, F; Gaitan, MJ; Machuca, J; Marchal, C; Perea-Milla, E; Redondo, M; Reyes-Engel, A1
Choi, JS; Kim, HJ; Kim, HN; Kim, YK; Lee, IK; Lee, JJ; Park, KS; Shin, MG; Shin, MH; Tran, HT; Yang, DH1
Brockton, NT; Cassidy, J; Cotton, SC; Haites, NE; Little, J; Masson, LF; Sharp, L1
Chatzikyriakidou, A; Georgiou, I; Kolaitis, N; Kolios, G; Michalis, LK; Naka, KK; Vakalis, KV1
Dardir, AA; El Awady, MK; Ezzat, A; Hossieny, LE; Khass, M; Meguid, NA1
Hiraki, A; Hirose, K; Iwata, H; Kawase, T; Matsuo, K; Suzuki, T; Tajima, K; Watanabe, M; Yamashita, T1
Abdelmouttaleb, I; Amouzou, EK; Barraud, H; Bigard, MA; Bronowicki, JP; Chabi, N; Guéant, JL; Halfon, P; Khiri, H; Le Faou, A; Peyrin-Biroulet, L; Sanni, A; Venard, V1
Gialeraki, A; Komporozos, C; Kremastinos, DT; Lekakis, I; Pavlakis, G; Rallidis, LS; Travlou, A; Vavoulis, P1
Feng, L; Lv, JJ; Qiao, FY; Wang, SS1
Bi, XH; Zhang, JW; Zhang, ZX; Zhao, HL1
Benyamina, A; Debuire, B; Karila, L; Lemoine, A; Marill, C; Pham, P; Reffas, M; Reynaud, M; Saffroy, R1
Baccarelli, A; Cassano, PA; Litonjua, A; Park, SK; Schwartz, J; Sparrow, D; Suh, H; Vokonas, P1
Hoey, L; McNulty, H; Pentieva, K; Ward, M1
Brouns, R; Hop, W; Lindemans, J; Pluijm, S; Steegers, E; Steegers-Theunissen, R; Ursem, N1
Brockton, NT1
Aydintuğ, OT; Duman, T; Düzgün, N; Ertuğrul, E; Köse, K; Morris, Y; Tutkak, H1
Azzari, C; Bartolini, E; Indolfi, G; Resti, M; Trapani, S1
Ahlbom, A; Auvinen, A; Bethke, L; Christensen, HC; Dimitropoulou, P; Feychting, M; Henriksson, R; Hepworth, S; Houlston, R; Johansen, C; Kiuru, A; Lönn, S; Lophatananon, A; Malmer, B; McKinney, P; Muir, K; Murray, A; Salminen, T; Schoemaker, M; Swerdlow, A; Webb, E1
Bellingham, G; Duffy, DL; Duffy, P; Martin, NG; Mitchell, LE1
Artigas, C; Fuchs, C; Giovannucci, E; Hennekens, CH; Hunter, DJ; Ma, J; Rozen, R; Selhub, J; Stampfer, MJ; Willett, WC1
Fletcher, O; Kessling, AM1
Boer, J; Kolbach, DN1
Alikaşifoğlu, M; Anar, B; Boduroğlu, K; Tunçbilek, E1
Bostom, AG; Selhub, J1
Beilby, JP; Hung, J; McQuillan, BM; Nidorf, M; Thompson, PL1
Alders, D; de Jong, SC; Jakobs, C; Kostense, PJ; Pals, G; Rauwerda, JA; Stehouwer, CD; van den Berg, M1
Adler, Y; Birnbaum, Y; Lalezari, S; Magal, N; Mager, A; Shohat, M; Shohat, T1
King, IB; Mahomed, K; Malinow, MR; Rajkovic, A; Rozen, R; Williams, MA1
Little, J1
Alagratnam, D; Swaminathan, R; Turner, C; Wickramasinghe, SN; Wierzbicki, AS1
Artuch, R; Campistol, J; Cardo, E; Colomé, C; Monrós, E; Pineda, M; Vilaseca, MA1
Law, MR; Wald, NJ1
Hine, RJ; Hobbs, CA; Hopkins, SE; James, SJ; Pogribna, M; Rozen, R; Sherman, SL; Torfs, CP; Yi, P1
Rozen, R1
Boers, GH1
Boers, GH; Naughten, ER; Wilcken, B; Wilcken, DE; Yap, S1
Law, M1
Ben-Yehuda, A; Friedlander, Y; Friedman, G; Goldschmidt, N; Raz, I; Shpichinetsky, V; Wexler, ID1
Ho, CH1
Gallinger, S; Kim, YI; Mason, JB; Medline, A; Song, J1
Bridge, PJ; Fick, G; Hyndman, ME; Parsons, HG; Warnica, JW1
Barber, RC; Bennett, GD; Eberwine, JH; Finnell, RH; Gelineau-van Waes, J; Lammer, EJ; Piedrahita, JA; Shaw, GM; Wlodarczyk, B1
Kluijtmans, LA; Whitehead, AS1
Chen, J; Hennekens, CH; Hunter, DJ; Ma, J; Malinow, MR; Selhub, J; Stampfer, MJ1
Billett, HH; Estrada, DA1
Asakura, S; Hamajima, N; Kaba, S; Kagami, Y; Kondoh, E; Maeda, S; Matsuo, K; Morishima, Y; Nakamura, S; Ogura, M; Seto, M; Suzuki, R; Taji, H; Tajima, K1
Axenti, I; Brzostek, T; Czachór, R; Dropiński, J; Jankowski, M; Musiał, J; Sanak, M; Szczeklik, A; Tendera, M; Twardowska, M1
Burrage, LC; Chan, ER; Hassold, TJ; Jacobs, PA; James, SJ; Judis, LM; Schwartz, S; Thomas, NS1
Pawlak, AL; Strauss, E1
Alink, G; Andersen, R; Braesco, V; Crews, H; Holst, B; Maiani, G; Ovesen, L; Scotter, M; Solfrizzo, M; van den Berg, R; Verhagen, H; Williamson, G1
Andersson, C; O'Brien, NM; Wild, CP; Wilson, L; Woods, JA1
Blom, HJ; de Boo, TM; Giesendorf, BA; Haagsma, CJ; Huizinga, TW; Laan, RF; van de Putte, LB; van Ede, AE1
Danese, S; Gasbarrini, A; Gasbarrini, G; Papa, A1
Almasy, L; Blanco-Vaca, F; Blangero, J; Borrell, M; Fontcuberta, J; Soria, JM; Souto, JC; Stone, WH1
Baker, MW; Finnell, RH; Lammer, EJ; Neri, E; Shaw, GM; Zhu, H1
Cartwright, RA; Hubbard, A; Law, GR; Morgan, GJ; Roberts, AC; Rollinson, S; Roman, E; Shane, B; Skibola, CF; Smith, MT1
Malcolm, S; Prescott, NJ1
Barron, M; Furie, KL; Kelly, PJ1
Pauker, SP1
Kampmann, T; Pasarge, E; Rüdiger, HW; Schmidt, A; Tan, TL1

Reviews

84 review(s) available for folic acid and Genetic Predisposition

ArticleYear
Associations between folate metabolism enzyme polymorphisms and breast cancer: A meta-analysis.
    The breast journal, 2020, Volume: 26, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Breast Neoplasms; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors

2020
SNPs in folate pathway are associated with the risk of nonsyndromic cleft lip with or without cleft palate, a meta-analysis.
    Bioscience reports, 2020, 03-27, Volume: 40, Issue:3

    Topics: Asian People; Brain; Case-Control Studies; China; Cleft Lip; Cleft Palate; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Homocystinuria; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Polymorphism, Single Nucleotide; Psychotic Disorders; Risk Factors

2020
    Genes, 2021, 04-17, Volume: 12, Issue:4

    Topics: Brain Neoplasms; Breast Neoplasms; DNA Methylation; Female; Folic Acid; Genetic Predisposition to Disease; Glioma; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Stomach Neoplasms

2021
Genetic Risk Factors for Folate-Responsive Neural Tube Defects.
    Annual review of nutrition, 2017, 08-21, Volume: 37

    Topics: Animals; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Mice; Neural Tube Defects; Risk Factors

2017
Should vitamin B
    Annals of the New York Academy of Sciences, 2018, Volume: 1414, Issue:1

    Topics: Case-Control Studies; Female; Folic Acid; Food, Fortified; Genetic Predisposition to Disease; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Nutritional Status; Pregnancy; Randomized Controlled Trials as Topic; Risk Assessment; Risk Factors; Vitamin B 12; Vitamin B 12 Deficiency

2018
Analytic Approaches for the Treatment of Hyperhomocysteinemia and Its Impact on Vascular Disease.
    Cardiovascular drugs and therapy, 2018, Volume: 32, Issue:2

    Topics: Animals; Betaine; Biomarkers; Cardiovascular Diseases; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Phenotype; Risk Factors; Tetrahydrofolates; Treatment Outcome

2018
LOXL1 Polymorphisms: Genetic Biomarkers that Presage Environmental Determinants of Exfoliation Syndrome.
    Journal of glaucoma, 2018, Volume: 27 Suppl 1

    Topics: Amino Acid Oxidoreductases; Coffee; Exfoliation Syndrome; Folic Acid; Gene-Environment Interaction; Genetic Markers; Genetic Predisposition to Disease; Glaucoma, Open-Angle; Humans; Intraocular Pressure; Polymorphism, Single Nucleotide; Risk Factors

2018
Linking genetics to epigenetics: The role of folate and folate-related pathways in neurodevelopmental disorders.
    Clinical genetics, 2019, Volume: 95, Issue:2

    Topics: Animals; Biomarkers; Diet; DNA Methylation; Epigenesis, Genetic; Folic Acid; Gene Expression Regulation; Genetic Predisposition to Disease; Genetic Variation; Humans; Metabolic Networks and Pathways; Neurodevelopmental Disorders; Neurogenesis

2019
Targeting MTHFR for the treatment of migraines.
    Expert opinion on therapeutic targets, 2019, Volume: 23, Issue:1

    Topics: Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Migraine Disorders; Molecular Targeted Therapy; Polymorphism, Genetic; Vitamin B 12; Vitamin B 6

2019
MTHFR polymorphisms as risk for male infertility in Pakistan and its comparison with socioeconomic status in the world.
    Personalized medicine, 2019, Volume: 16, Issue:1

    Topics: Alleles; Case-Control Studies; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Infertility, Male; Male; Methylenetetrahydrofolate Reductase (NADPH2); Pakistan; Polymorphism, Single Nucleotide; Risk Factors; Social Class; White People

2019
Disturbed homocysteine metabolism is associated with cancer.
    Experimental & molecular medicine, 2019, 02-21, Volume: 51, Issue:2

    Topics: Alleles; Animals; Cystathionine beta-Synthase; Disease Susceptibility; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hydrogen Sulfide; Hyperhomocysteinemia; Metabolic Networks and Pathways; Neoplasms; Polymorphism, Genetic; Risk Factors; Sulfur; Thromboembolism

2019
The role of one-carbon metabolism and homocysteine in Parkinson's disease onset, pathology and mechanisms.
    Nutrition research reviews, 2019, Volume: 32, Issue:2

    Topics: Animals; Diet; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Levodopa; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; One-Carbon Group Transferases; Parkinson Disease; Polymorphism, Genetic; Vitamin B Complex

2019
Methylenetetrahydrofolate reductase genetic polymorphisms and esophageal squamous cell carcinoma susceptibility: a meta-analysis of case-control studies.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:1

    Topics: Carcinoma, Squamous Cell; Case-Control Studies; Confidence Intervals; Diet; Esophageal Neoplasms; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors

2013
Association between MTHFR gene polymorphisms and the risk of autism spectrum disorders: a meta-analysis.
    Autism research : official journal of the International Society for Autism Research, 2013, Volume: 6, Issue:5

    Topics: Case-Control Studies; Child; Child Development Disorders, Pervasive; Cross-Cultural Comparison; Developing Countries; Epigenesis, Genetic; Folic Acid; Folic Acid Deficiency; Food, Fortified; Gene Frequency; Genetic Carrier Screening; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Risk Factors

2013
Neural tube defects: recent advances, unsolved questions, and controversies.
    The Lancet. Neurology, 2013, Volume: 12, Issue:8

    Topics: Animals; Databases, Factual; Disease Models, Animal; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects

2013
Association between C677T polymorphism of methylene tetrahydrofolate reductase and congenital heart disease: meta-analysis of 7697 cases and 13,125 controls.
    Circulation. Cardiovascular genetics, 2013, Volume: 6, Issue:4

    Topics: Alleles; Cohort Studies; Databases, Genetic; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors

2013
Maternal gene polymorphisms involved in folate metabolism and the risk of having a Down syndrome offspring: a meta-analysis.
    Mutagenesis, 2013, Volume: 28, Issue:6

    Topics: Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors

2013
Folate intake and MTHFR polymorphism C677T is not associated with ovarian cancer risk: evidence from the meta-analysis.
    Molecular biology reports, 2013, Volume: 40, Issue:12

    Topics: Diet; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Models, Genetic; Ovarian Neoplasms; Polymorphism, Single Nucleotide; Risk Factors

2013
The MTR 2756A>G polymorphism and maternal risk of birth of a child with Down syndrome: a case-control study and a meta-analysis.
    Molecular biology reports, 2013, Volume: 40, Issue:12

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Case-Control Studies; Confidence Intervals; Demography; Down Syndrome; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Italy; Metabolic Networks and Pathways; Odds Ratio; Parturition; Polymorphism, Single Nucleotide; Risk Factors

2013
The MTRR 66A>G polymorphism and maternal risk of birth of a child with Down syndrome in Caucasian women: a case-control study and a meta-analysis.
    Molecular biology reports, 2014, Volume: 41, Issue:9

    Topics: Adult; Aged; Alleles; Biomarkers; Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Genotyping Techniques; Heterozygote; Homocysteine; Humans; Logistic Models; Middle Aged; Mothers; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B 12; White People

2014
"Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis".
    Metabolic brain disease, 2015, Volume: 30, Issue:1

    Topics: Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Odds Ratio; Polymorphism, Single Nucleotide; Pregnancy; Publication Bias; Risk Factors

2015
Neural tube defects.
    Annual review of neuroscience, 2014, Volume: 37

    Topics: Animals; Folic Acid; Genetic Predisposition to Disease; Humans; Neural Tube Defects; Neurulation; Risk Factors

2014
Lack of Association Between MTHFR, MTR, MTRR, and TCN2 Genes and Nonsyndromic CL±P in a Chinese Population: Case-Control Study and Meta-Analysis.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2015, Volume: 52, Issue:5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alleles; Case-Control Studies; China; Cleft Lip; Cleft Palate; Ferredoxin-NADP Reductase; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Haplotypes; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Transcobalamins

2015
[The influence of genes and environment on the development of autism spectrum disorders].
    Tijdschrift voor psychiatrie, 2014, Volume: 56, Issue:10

    Topics: Child Development Disorders, Pervasive; Environment; Folic Acid; Genetic Predisposition to Disease; Humans; Mutation; Risk Factors

2014
Folate pathway gene MTHFR C677T polymorphism and risk of lung cancer in Asian populations.
    Asian Pacific journal of cancer prevention : APJCP, 2014, Volume: 15, Issue:21

    Topics: Asian People; Case-Control Studies; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Lung Neoplasms; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Risk Factors; Signal Transduction

2014
Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism: epidemiology, metabolism and the associated diseases.
    European journal of medical genetics, 2015, Volume: 58, Issue:1

    Topics: Diabetes Mellitus; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Infertility; Mental Disorders; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Nervous System Diseases; Polymorphism, Genetic; Psoriasis; Vascular Diseases; Vitamin B 12

2015
Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for preeclampsia: a meta-analysis.
    Journal of assisted reproduction and genetics, 2015, Volume: 32, Issue:5

    Topics: Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pre-Eclampsia; Pregnancy; Prognosis; Risk Factors

2015
Role of genetic mutations in folate-related enzyme genes on Male Infertility.
    Scientific reports, 2015, Nov-09, Volume: 5

    Topics: Asthenozoospermia; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Infertility, Male; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oligospermia; Polymorphism, Single Nucleotide; Risk Factors

2015
Association between eNOS polymorphisms and risk of coronary artery disease in a Korean population: a meta-analysis.
    Genetics and molecular research : GMR, 2015, Dec-09, Volume: 14, Issue:4

    Topics: Aged; Alleles; Asian People; Case-Control Studies; Comorbidity; Coronary Artery Disease; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Homocysteine; Humans; Linkage Disequilibrium; Male; Middle Aged; Nitric Oxide Synthase Type III; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Republic of Korea; Risk; Risk Factors

2015
Synthetic combinations of missense polymorphic genetic changes underlying Down syndrome susceptibility.
    Cellular and molecular life sciences : CMLS, 2016, Volume: 73, Issue:21

    Topics: Down Syndrome; Folic Acid; Genetic Predisposition to Disease; Humans; Mutation, Missense; Polymorphism, Single Nucleotide; Tumor Suppressor Protein p53

2016
Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders.
    Psychiatric genetics, 2016, Volume: 26, Issue:6

    Topics: Alleles; Autism Spectrum Disorder; Autistic Disorder; Child; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors

2016
The worldwide challenge of the dementias: a role for B vitamins and homocysteine?
    Food and nutrition bulletin, 2008, Volume: 29, Issue:2 Suppl

    Topics: Aged; Aged, 80 and over; Aging; Dementia; Environment; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Risk Factors; Vitamin B 12; Vitamin B Complex

2008
Folate status in various pathophysiological conditions.
    IUBMB life, 2008, Volume: 60, Issue:12

    Topics: Animals; Cardiovascular Diseases; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Malabsorption Syndromes; Neoplasms; Nervous System Diseases; Neural Tube Defects

2008
Homocysteine and depression in later life.
    Archives of general psychiatry, 2008, Volume: 65, Issue:11

    Topics: Age Factors; Aged; Cohort Studies; Depressive Disorder; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Personality Inventory; Polymorphism, Genetic; Pyridoxine; Randomized Controlled Trials as Topic; Risk Factors; Vitamin B 12

2008
Mechanistic insights into folate supplementation from Crooked tail and other NTD-prone mutant mice.
    Birth defects research. Part A, Clinical and molecular teratology, 2009, Volume: 85, Issue:4

    Topics: Animals; Body Patterning; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Metabolic Networks and Pathways; Mice; Mice, Mutant Strains; Models, Biological; Neural Tube Defects; Pregnancy; Tail

2009
The search for genetic polymorphisms in the homocysteine/folate pathway that contribute to the etiology of human neural tube defects.
    Birth defects research. Part A, Clinical and molecular teratology, 2009, Volume: 85, Issue:4

    Topics: Clinical Trials as Topic; DNA Mutational Analysis; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Metabolic Networks and Pathways; Models, Biological; Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Research

2009
Folate nutrigenetics: a convergence of dietary folate metabolism, folic acid supplementation, and folate antagonist pharmacogenetics.
    Drug metabolism letters, 2007, Volume: 1, Issue:1

    Topics: Alleles; Dietary Supplements; Folic Acid; Folic Acid Antagonists; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Pharmacogenetics; Vitamin B Complex

2007
Role of the MTHFR polymorphisms in cancer risk modification and treatment.
    Future oncology (London, England), 2009, Volume: 5, Issue:4

    Topics: Antineoplastic Agents; Drug Resistance, Neoplasm; Fluorouracil; Folic Acid; Genetic Predisposition to Disease; Humans; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Polymorphism, Single Nucleotide; Risk Factors

2009
Importance of gene-environment interactions in the etiology of selected birth defects.
    Clinical genetics, 2009, Volume: 75, Issue:5

    Topics: Animals; Cleft Palate; Congenital Abnormalities; Disease Susceptibility; Environmental Exposure; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Maternal Exposure; Neural Tube Defects

2009
Investigation of inter-individual variability of the one-carbon folate pathway: a bioinformatic and genetic review.
    The pharmacogenomics journal, 2009, Volume: 9, Issue:5

    Topics: Animals; Computational Biology; Databases, Genetic; Epigenesis, Genetic; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetics, Population; Humans; Hyperhomocysteinemia; Metabolomics; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Transgenic; Models, Animal; Pharmacogenetics; Phenotype; Polymorphism, Single Nucleotide

2009
Perinatal depression: prevalence, risks, and the nutrition link--a review of the literature.
    Journal of the American Dietetic Association, 2009, Volume: 109, Issue:9

    Topics: Calcium; Calcium, Dietary; Depression; Depression, Postpartum; Environment; Fatty Acids, Omega-3; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Iron; Iron, Dietary; Maternal Nutritional Physiological Phenomena; Nutritional Requirements; Nutritional Status; Postpartum Period; Pregnancy; Pregnancy Complications; Prenatal Nutritional Physiological Phenomena; Prevalence; Risk Factors; Vitamin B Complex

2009
Association of folate-pathway gene polymorphisms with the risk of prostate cancer: a population-based nested case-control study, systematic review, and meta-analysis.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009, Volume: 18, Issue:9

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Case-Control Studies; Folic Acid; Genetic Predisposition to Disease; Glutamate Carboxypeptidase II; Glycine Hydroxymethyltransferase; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Minor Histocompatibility Antigens; Polymorphism, Genetic; Prostatic Neoplasms; Risk Factors

2009
Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia.
    British journal of haematology, 2010, Volume: 148, Issue:1

    Topics: Child; Folic Acid; Genes, Neoplasm; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2010
[Genetic conditioned changes in activity of 5,10-methylenetetrahydrofolate reductase (MTHFR) and recurrent miscarriages].
    Ginekologia polska, 2009, Volume: 80, Issue:10

    Topics: Abortion, Habitual; Female; Folic Acid; Gene Expression Regulation, Enzymologic; Gene Frequency; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Polymorphism, Genetic; Pregnancy; Risk Factors; Tetrahydrofolates

2009
Aetiology of childhood leukaemia.
    Cancer treatment reviews, 2010, Volume: 36, Issue:4

    Topics: Alcohol Drinking; Background Radiation; Child; Electromagnetic Fields; Folic Acid; Genetic Predisposition to Disease; Humans; Incidence; Leukemia; Seasons; Smoking

2010
MTRR A66G polymorphism and breast cancer risk: a meta-analysis.
    Breast cancer research and treatment, 2010, Volume: 124, Issue:3

    Topics: Asian People; Breast Neoplasms; Case-Control Studies; Confidence Intervals; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Models, Genetic; Odds Ratio; Phenotype; Polymorphism, Genetic; Risk Assessment; Risk Factors; White People

2010
Genes, environment, and orofacial clefting: N-acetyltransferase and folic acid.
    The Journal of craniofacial surgery, 2010, Volume: 21, Issue:5

    Topics: 6-Aminonicotinamide; Animals; Arylamine N-Acetyltransferase; Cleft Lip; Cleft Palate; Disease Models, Animal; DNA Methylation; Folic Acid; Genetic Predisposition to Disease; Hydrocortisone; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Phenytoin; Polymerase Chain Reaction; Risk Factors

2010
[Genes involved in folate metabolim and neural tube defects].
    Zhonghua fu chan ke za zhi, 2011, Volume: 46, Issue:4

    Topics: Female; Folic Acid; Folic Acid Transporters; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Single Nucleotide; Pregnancy; Reduced Folate Carrier Protein; Risk Factors

2011
Down syndrome as a model of DNA polymerase beta haploinsufficiency and accelerated aging.
    Mechanisms of ageing and development, 2012, Volume: 133, Issue:4

    Topics: Aging; Animals; DNA Polymerase beta; DNA Repair; Down Syndrome; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Genomic Instability; Haploinsufficiency; Humans; Leukemia; MicroRNAs; Oxidative Stress; Phenotype

2012
C(1) metabolism and CVD outcomes in older adults.
    The Proceedings of the Nutrition Society, 2012, Volume: 71, Issue:2

    Topics: Blood Pressure; Carbon; Cardiovascular Diseases; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Diseases; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Riboflavin; Stroke; Vitamin B Complex

2012
Epigenetic biomarkers of colorectal cancer: Focus on DNA methylation.
    Cancer letters, 2014, Jan-28, Volume: 342, Issue:2

    Topics: Animals; Biomarkers, Tumor; Colorectal Neoplasms; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genetic Testing; Humans; Phenotype; Predictive Value of Tests; Pregnancy; Prenatal Care; Prenatal Exposure Delayed Effects; Prognosis; Risk Factors; Vitamin B Complex

2014
Polymorphisms in the folate-metabolizing genes MTR, MTRR, and CBS and breast cancer risk.
    Cancer epidemiology, 2012, Volume: 36, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Breast Neoplasms; Cystathionine beta-Synthase; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; Risk Factors

2012
Folate gene polymorphisms MTR A2756G, MTRR A66G, and BHMT G742A and risk for coronary artery disease: a meta-analysis.
    Genetic testing and molecular biomarkers, 2012, Volume: 16, Issue:6

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Betaine-Homocysteine S-Methyltransferase; Case-Control Studies; Coronary Artery Disease; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Humans; Polymorphism, Genetic; Risk

2012
Mouse as a model for multifactorial inheritance of neural tube defects.
    Birth defects research. Part C, Embryo today : reviews, 2012, Volume: 96, Issue:2

    Topics: Anencephaly; Animals; Disease Models, Animal; Folic Acid; Genetic Predisposition to Disease; Humans; Mice; Multifactorial Inheritance; Neural Tube Defects; Spinal Dysraphism

2012
Genetic causes of cerebral folate deficiency: clinical, biochemical and therapeutic aspects.
    Drug discovery today, 2012, Volume: 17, Issue:23-24

    Topics: Betaine; Cerebral Cortex; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Intestinal Absorption; Leucovorin; Nervous System Diseases; Tetrahydrofolates

2012
[Folic acid metabolism gene polymorphism and congenital heart disease].
    Zhonghua er ke za zhi = Chinese journal of pediatrics, 2012, Volume: 50, Issue:8

    Topics: Child, Preschool; Cystathionine beta-Synthase; Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Methyltransferases; Minor Histocompatibility Antigens; Polymorphism, Genetic; Risk Factors

2012
Folate-genetics and colorectal neoplasia: what we know and need to know next.
    Molecular nutrition & food research, 2013, Volume: 57, Issue:4

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Colorectal Neoplasms; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Meta-Analysis as Topic; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide; Randomized Controlled Trials as Topic; Risk Factors; S-Adenosylmethionine; Thymidylate Synthase

2013
Epidemiologic studies of folate and colorectal neoplasia: a review.
    The Journal of nutrition, 2002, Volume: 132, Issue:8 Suppl

    Topics: Colorectal Neoplasms; Diet; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Male; Methionine; Risk Factors

2002
[Colorectal cancer and folate].
    Zeitschrift fur Gastroenterologie, 2003, Volume: 41, Issue:3

    Topics: Colorectal Neoplasms; DNA Damage; DNA Methylation; Epidemiologic Studies; Feeding Behavior; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors

2003
Pathobiology and genetics of neural tube defects.
    Epilepsia, 2003, Volume: 44 Suppl 3

    Topics: Animals; Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Infant, Newborn; Mice; Mice, Neurologic Mutants; Neural Tube Defects; Pharmacogenetics; Pregnancy; Pregnancy Complications; Risk Factors; Spinal Dysraphism

2003
Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.
    American journal of epidemiology, 2004, Mar-01, Volume: 159, Issue:5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Colorectal Neoplasms; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Risk Factors

2004
[Methylenetetrahydrofolate reductase polymorphisms and colorectal cancer risk: a human genomic epidemiologic review].
    Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2004, Volume: 33, Issue:5

    Topics: China; Colorectal Neoplasms; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Risk Factors

2004
[Advances in the study of the etiologic relationship between reduced folate carrier gene (RFC1) and neural tube and craniofacial defects].
    Yi chuan = Hereditas, 2004, Volume: 26, Issue:2

    Topics: Carrier Proteins; Craniofacial Abnormalities; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Membrane Transport Proteins; Neural Tube Defects; Polymorphism, Genetic; Receptors, Cell Surface; Reduced Folate Carrier Protein

2004
Dose-related association of MTHFR 677T allele with risk of ischemic stroke: evidence from a cumulative meta-analysis.
    Stroke, 2005, Volume: 36, Issue:7

    Topics: Adult; Aged; Alleles; Brain Ischemia; Female; Folic Acid; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Odds Ratio; Phenotype; Polymorphism, Genetic; Risk; Stroke

2005
Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma.
    Cancer science, 2005, Volume: 96, Issue:9

    Topics: Adenoma; Colorectal Neoplasms; Epidemiologic Studies; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; Polymorphism, Genetic

2005
Folate and methylenetetrahydrofolate reductase polymorphisms: new nutritional and genetic risk factors for pancreatic cancer?
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:8

    Topics: Amino Acid Substitution; Diet; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Pancreatic Neoplasms; Polymorphism, Single Nucleotide; Risk Factors

2005
The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis.
    Molecular psychiatry, 2006, Volume: 11, Issue:4

    Topics: Aged; Amino Acid Substitution; Depressive Disorder; Female; Folic Acid; Genetic Linkage; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; United Kingdom; Women's Health

2006
Etiology, pathogenesis and prevention of neural tube defects.
    Congenital anomalies, 2006, Volume: 46, Issue:2

    Topics: Anencephaly; Animals; Embryonic Development; Encephalocele; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Models, Anatomic; Models, Biological; Neural Crest; Neural Tube Defects; Pregnancy; Spinal Dysraphism

2006
Neural tube defects and folate: case far from closed.
    Nature reviews. Neuroscience, 2006, Volume: 7, Issue:9

    Topics: Animals; Central Nervous System; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Homocysteine; Humans; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects

2006
[Genetic determinants of childhood leukemia].
    Bulletin du cancer, 2006, Volume: 93, Issue:9

    Topics: Adolescent; Carcinogens; Child; Cytochrome P-450 Enzyme System; Environment; Female; Folic Acid; Genetic Predisposition to Disease; Glutathione Transferase; Humans; Male; Maternal Exposure; Oxidative Stress; Paternal Exposure; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2006
Systematic review: managing anaemia in Crohn's disease.
    Alimentary pharmacology & therapeutics, 2006, Volume: 24, Issue:11-12

    Topics: Anemia; Crohn Disease; Ferric Compounds; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Vitamin B 12; Vitamin B 12 Deficiency

2006
Genetic polymorphisms and esophageal cancer risk.
    International journal of cancer, 2007, Oct-15, Volume: 121, Issue:8

    Topics: Adenocarcinoma; Alcohol Oxidoreductases; Carcinoma, Squamous Cell; Cytochrome P-450 Enzyme System; DNA Repair; Esophageal Neoplasms; Folic Acid; Genes, cdc; Genetic Predisposition to Disease; Humans; Meta-Analysis as Topic; Odds Ratio; Oncogenes; Polymorphism, Genetic; Risk Factors

2007
Homocysteine, B-vitamins and CVD.
    The Proceedings of the Nutrition Society, 2008, Volume: 67, Issue:2

    Topics: Cardiovascular Diseases; Folic Acid; Food, Fortified; Genetic Predisposition to Disease; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nutrition Policy; Nutritional Status; Polymorphism, Genetic; Vitamin B Complex

2008
MTHFR association with arteriosclerotic vascular disease?
    Human genetics, 1998, Volume: 103, Issue:1

    Topics: Alleles; Arteriosclerosis; Databases, Bibliographic; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Homozygote; Humans; MEDLINE; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation

1998
Problems and approaches in investigating the role of micronutrients in the aetiology of cancer in humans.
    British medical bulletin, 1999, Volume: 55, Issue:3

    Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Arylamine N-Acetyltransferase; Colorectal Neoplasms; Folic Acid; Genetic Predisposition to Disease; Hemochromatosis; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Micronutrients; Neoplasms; Oxidoreductases; Polymorphism, Genetic; Protective Agents; Research Design

1999
Homocysteine and ischaemic heart disease.
    Haematologica, 1999, Volume: 84 Suppl EHA-4

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Case-Control Studies; Cohort Studies; Comorbidity; Cystathionine beta-Synthase; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methionine; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Ischemia; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Retrospective Studies

1999
Genetic modulation of homocysteinemia.
    Seminars in thrombosis and hemostasis, 2000, Volume: 26, Issue:3

    Topics: Amino Acid Substitution; Cardiovascular Diseases; Cystathionine beta-Synthase; Cysteine; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Methylation; Methylenetetrahydrofolate Reductase (NADPH2); Methyltransferases; Mutation, Missense; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymorphism, Genetic; Sulfur; Tetrahydrofolates

2000
Mild hyperhomocysteinemia is an independent risk factor of arterial vascular disease.
    Seminars in thrombosis and hemostasis, 2000, Volume: 26, Issue:3

    Topics: Arteriosclerosis; Case-Control Studies; Clinical Trials as Topic; Comorbidity; Coronary Disease; Folic Acid; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Hypertension; Meta-Analysis as Topic; Multicenter Studies as Topic; Oxidative Stress; Pyridoxine; Risk Factors; Smoking; Vitamin B 12

2000
Vascular complications of severe hyperhomocysteinemia in patients with homocystinuria due to cystathionine beta-synthase deficiency: effects of homocysteine-lowering therapy.
    Seminars in thrombosis and hemostasis, 2000, Volume: 26, Issue:3

    Topics: Adolescent; Adult; Aged; Australia; Child; Child, Preschool; Cohort Studies; Cystine; Drug Resistance; Female; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Infant; Ireland; Male; Methionine; Middle Aged; Netherlands; Pyridoxine; Risk; Risk Factors; Thrombophilia; Vascular Diseases; Vitamin B 12

2000
Fortifying food with folic acid.
    Seminars in thrombosis and hemostasis, 2000, Volume: 26, Issue:3

    Topics: Bread; Case-Control Studies; Colonic Neoplasms; Dietary Supplements; Dose-Response Relationship, Drug; Edible Grain; Europe; Flour; Folic Acid; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Incidence; Legislation, Food; Myocardial Ischemia; Neural Tube Defects; Nutritional Requirements; Odds Ratio; Prospective Studies; Stroke; United States

2000
[Polymorphism of the methylenetetrahydrofolate reductase gene (MTHFR) and incidence of hyperhomocysteinemia-related diseases].
    Postepy higieny i medycyny doswiadczalnej, 2001, Volume: 55, Issue:2

    Topics: Folic Acid; Gene Expression Regulation, Enzymologic; Gene Frequency; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Incidence; Methylenetetrahydrofolate Dehydrogenase (NADP); Mutation; Polymorphism, Genetic; Risk Factors; Spinal Dysraphism

2001
A critical assessment of some biomarker approaches linked with dietary intake.
    The British journal of nutrition, 2001, Volume: 86 Suppl 1

    Topics: Aflatoxins; Antioxidants; Biomarkers; Brassica; Carotenoids; Developing Countries; Diet; Environmental Exposure; Flavonoids; Folic Acid; Food Additives; Food Analysis; Food Contamination; Free Radicals; Genetic Predisposition to Disease; Humans; Intestinal Absorption; Meat; Neoplasms; Nutritional Status; Polycyclic Aromatic Hydrocarbons; Predictive Value of Tests; Reproducibility of Results; Selenium; Selenium Compounds; Sensitivity and Specificity; Vitamin A; Vitamin B 12; Vitamin B Deficiency

2001
A critical evaluation of the application of biomarkers in epidemiological studies on diet and health.
    The British journal of nutrition, 2001, Volume: 86 Suppl 1

    Topics: Biomarkers; Colorectal Neoplasms; Cooking; Diet; Epidemiologic Factors; Estrogens, Non-Steroidal; Female; Folic Acid; Genetic Predisposition to Disease; Genistein; Health Surveys; Heterocyclic Compounds; Humans; Iodine; Isoflavones; Male; Meat; Middle Aged; Neural Tube Defects; Nutritional Status; Phytoestrogens; Plant Preparations; Predictive Value of Tests; Pregnancy; Prostatic Neoplasms; Risk Factors; Specimen Handling; Vitamin D

2001
Folate and the face: evaluating the evidence for the influence of folate genes on craniofacial development.
    The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association, 2002, Volume: 39, Issue:3

    Topics: Cleft Lip; Cleft Palate; Dietary Supplements; Disease Susceptibility; Environment; Face; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Genetic Variation; Humans; Phenotype; Pregnancy

2002

Trials

20 trial(s) available for folic acid and Genetic Predisposition

ArticleYear
Predictors of Hand-Foot Syndrome and Pyridoxine for Prevention of Capecitabine-Induced Hand-Foot Syndrome: A Randomized Clinical Trial.
    JAMA oncology, 2017, Nov-01, Volume: 3, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Asian People; Capecitabine; Chi-Square Distribution; Dihydrouracil Dehydrogenase (NADP); Double-Blind Method; Drug Administration Schedule; Female; Folic Acid; Genetic Predisposition to Disease; Genome-Wide Association Study; Hand-Foot Syndrome; Humans; Incidence; Intracellular Signaling Peptides and Proteins; Kaplan-Meier Estimate; Logistic Models; Male; Membrane Proteins; Microfilament Proteins; Middle Aged; Multivariate Analysis; Neoplasms; Odds Ratio; Pharmacogenomic Variants; Polymorphism, Single Nucleotide; Predictive Value of Tests; Pyridoxine; Risk Assessment; Risk Factors; Severity of Illness Index; Singapore; Time Factors; Treatment Outcome

2017
Folic acid supplementation for prevention of mood disorders in young people at familial risk: a randomised, double blind, placebo controlled trial.
    Journal of affective disorders, 2014, Volume: 167

    Topics: Bipolar Disorder; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Dietary Supplements; Double-Blind Method; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Incidence; Male; Risk

2014
Polymorphisms in folate-metabolizing enzymes and response to 5-fluorouracil among patients with stage II or III rectal cancer (INT-0144; SWOG 9304).
    Cancer, 2014, Nov-01, Volume: 120, Issue:21

    Topics: Adult; Aged; Aged, 80 and over; Disease-Free Survival; Female; Fluorouracil; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pharmacogenetics; Polymorphism, Single Nucleotide; Rectal Neoplasms; Reduced Folate Carrier Protein; Thymidylate Synthase

2014
Genetic and environmental risk assessment and colorectal cancer screening in an average-risk population: a randomized trial.
    Annals of internal medicine, 2014, Oct-21, Volume: 161, Issue:8

    Topics: Aged; Colorectal Neoplasms; Early Detection of Cancer; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Testing; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Patient Compliance; Polymorphism, Genetic; Precision Medicine; Risk; Risk Assessment

2014
B vitamin treatments modify the risk of myocardial infarction associated with a MTHFD1 polymorphism in patients with stable angina pectoris.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2016, Volume: 26, Issue:6

    Topics: Aged; Angina, Stable; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Kaplan-Meier Estimate; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Minor Histocompatibility Antigens; Myocardial Infarction; Norway; Phenotype; Polymorphism, Genetic; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Vitamin B 6; Vitamin B Complex

2016
Dietary folate, B vitamins, genetic susceptibility and progression to advanced nonexudative age-related macular degeneration with geographic atrophy: a prospective cohort study.
    The American journal of clinical nutrition, 2016, Volume: 103, Issue:4

    Topics: Aged; Body Mass Index; Collagen Type VIII; Complement C2; Complement C3; Complement Factor B; Complement Factor H; Disease Progression; Female; Folic Acid; Genetic Predisposition to Disease; Geographic Atrophy; High-Temperature Requirement A Serine Peptidase 1; Humans; Macular Degeneration; Male; Middle Aged; Prospective Studies; Proteins; Riboflavin; Serine Endopeptidases; Thiamine; Vitamin B Complex

2016
Maternal one-carbon metabolism, MTHFR and TCN2 genotypes and neural tube defects in India.
    Birth defects research. Part A, Clinical and molecular teratology, 2011, Volume: 91, Issue:9

    Topics: Adult; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; India; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Single Nucleotide; Transcobalamins; Vitamin B 12; Vitamin B 12 Deficiency

2011
Gene-nutrient and gene-gene interactions of controlled folate intake by Japanese women.
    Biochemical and biophysical research communications, 2004, Apr-16, Volume: 316, Issue:4

    Topics: Adult; Cardiovascular Diseases; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Testing; Homocysteine; Humans; Japan; Methylenetetrahydrofolate Reductase (NADPH2); Women's Health

2004
The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine.
    Atherosclerosis, 2004, Volume: 174, Issue:2

    Topics: Adult; Cohort Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Hyperhomocysteinemia; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Probability; Risk Assessment; Smoking

2004
Genetic determinants of folate status in Central Bohemia.
    Physiological research, 2005, Volume: 54, Issue:3

    Topics: Aryl Hydrocarbon Hydroxylases; Czech Republic; Dietary Supplements; DNA Mutational Analysis; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Testing; Humans; Lung Neoplasms; Male; Methylenetetrahydrofolate Dehydrogenase (NAD+); Middle Aged; Polymorphism, Genetic; Risk Assessment; Risk Factors

2005
[Efficacy and safety of two vitamin supplement regimens on homocysteine levels in hemodialysis patients. Prospective, randomized clinical trial].
    Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 2005, Volume: 25, Issue:3

    Topics: Aged; Aged, 80 and over; Cohort Studies; Diabetic Nephropathies; Dietary Supplements; Dose-Response Relationship, Drug; Double-Blind Method; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Prospective Studies; Renal Dialysis; Treatment Outcome; Vitamin B 12; Vitamin B 6

2005
Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients.
    Stroke, 2006, Volume: 37, Issue:2

    Topics: Aged; Coronary Artery Disease; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Ischemic Attack, Transient; Male; Methylenetetrahydrofolate Dehydrogenase (NAD+); Middle Aged; Models, Statistical; Placebos; Polymorphism, Genetic; Regression Analysis; Risk Factors; Singapore; Stroke; Vitamin B 12; Vitamin B 6; Vitamins

2006
Association of folate with hearing is dependent on the 5,10-methylenetetrahdyrofolate reductase 677C-->T mutation.
    Neurobiology of aging, 2006, Volume: 27, Issue:3

    Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Aged; Auditory Threshold; Female; Folic Acid; Genetic Predisposition to Disease; Hearing Loss, Sensorineural; Homocysteine; Humans; Incidence; Male; Middle Aged; Mutation; Netherlands; Polymorphism, Genetic; Risk Assessment; Risk Factors; Severity of Illness Index; Vitamin B 12

2006
Metabolic and genetic risk factors for migraine in children.
    Cephalalgia : an international journal of headache, 2006, Volume: 26, Issue:6

    Topics: Adolescent; Child; Child, Preschool; Comorbidity; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Italy; Male; Metabolic Diseases; Methylenetetrahydrofolate Reductase (NADPH2); Migraine Disorders; Mutation; Prevalence; Risk Assessment; Risk Factors; Thrombosis

2006
MTHFR 677 CT/MTHFR 1298 CC genotypes are associated with increased risk of hypertension in Indians.
    Molecular and cellular biochemistry, 2007, Volume: 302, Issue:1-2

    Topics: Asian People; Case-Control Studies; Cytosine; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Homocysteine; Humans; Hypertension; India; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Thymine

2007
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.
    Cancer research, 1997, Mar-15, Volume: 57, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Aspirin; beta Carotene; Case-Control Studies; Cocarcinogenesis; Colorectal Neoplasms; Diet; DNA Methylation; DNA Replication; Double-Blind Method; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymorphism, Genetic; Prospective Studies; Risk; Tetrahydrofolates; United States

1997
Association of the 677C-->T mutation on the methylenetetrahydrofolate reductase gene in Turkish patients with neural tube defects.
    Journal of child neurology, 1999, Volume: 14, Issue:3

    Topics: Adult; Alleles; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Testing; Genotype; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Turkey

1999
Serum homocysteine, folate and thermolabile variant of MTHFR in healthy Sri Lankans living in London.
    Atherosclerosis, 2000, Volume: 149, Issue:1

    Topics: Adult; Coronary Disease; Emigration and Immigration; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Homocysteine; Humans; London; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Reference Values; Sri Lanka

2000
Influence of a methionine synthase (D919G) polymorphism on plasma homocysteine and folate levels and relation to risk of myocardial infarction.
    Atherosclerosis, 2001, Feb-15, Volume: 154, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Case-Control Studies; Double-Blind Method; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Middle Aged; Myocardial Infarction; Polymorphism, Genetic; Prospective Studies

2001
The C677T mutation in the methylenetetrahydrofolate reductase gene: a genetic risk factor for methotrexate-related elevation of liver enzymes in rheumatoid arthritis patients.
    Arthritis and rheumatism, 2001, Volume: 44, Issue:11

    Topics: Alanine Transaminase; Antirheumatic Agents; Arthritis, Rheumatoid; Double-Blind Method; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Hematinics; Humans; Liver; Male; Methotrexate; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Severity of Illness Index; Treatment Outcome

2001

Other Studies

384 other study(ies) available for folic acid and Genetic Predisposition

ArticleYear
Human Leukocyte Antigen (HLA) Typing Study Identifies Maternal DQ2 Susceptibility Alleles among Infertile Women: Potential Associations with Autoimmunity and Micronutrients.
    Nutrients, 2021, Sep-19, Volume: 13, Issue:9

    Topics: Abortion, Habitual; Adult; Alleles; Autoimmune Diseases; Autoimmunity; Biomarkers; Female; Ferritins; Folic Acid; Genetic Predisposition to Disease; Genotype; Haplotypes; HLA-DQ Antigens; Humans; Infertility, Female; Micronutrients; Nutritional Status; Pregnancy; Risk Factors; Vitamin B 12; Vitamin D; Vitamin D Deficiency

2021
Combining genetic risk score with artificial neural network to predict the efficacy of folic acid therapy to hyperhomocysteinemia.
    Scientific reports, 2021, 11-02, Volume: 11, Issue:1

    Topics: Aged; Algorithms; Female; Folic Acid; Genetic Markers; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Male; Neural Networks, Computer; Prospective Studies; Risk Factors; Treatment Outcome

2021
Analysis of association between components of the folate metabolic pathway and autism spectrum disorder in eastern Indian subjects.
    Molecular biology reports, 2022, Volume: 49, Issue:2

    Topics: Alleles; Asian People; Autism Spectrum Disorder; Case-Control Studies; Cystathionine beta-Synthase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Haplotypes; Humans; India; Metabolic Networks and Pathways; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide

2022
One-carbon metabolism pathway genes and their non-association with the development of amyotrophic lateral sclerosis.
    Journal of cellular biochemistry, 2022, Volume: 123, Issue:3

    Topics: Amyotrophic Lateral Sclerosis; Carbon; Case-Control Studies; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Polymorphism, Single Nucleotide

2022
Using the optimal method-explained variance weighted genetic risk score to predict the efficacy of folic acid therapy to hyperhomocysteinemia.
    European journal of clinical nutrition, 2022, Volume: 76, Issue:7

    Topics: Folic Acid; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors

2022
Dark Green Leafy Vegetable Intake, MTHFR Genotype, and Risk of Cutaneous Squamous Cell Carcinoma.
    Dermatology (Basel, Switzerland), 2022, Volume: 238, Issue:4

    Topics: Australia; Carcinoma, Squamous Cell; Case-Control Studies; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Longitudinal Studies; Methylenetetrahydrofolate Reductase (NADPH2); Risk Factors; Skin Neoplasms; Vegetables

2022
Association of polymorphisms of FOLR1 gene and FOLR2 gene and maternal folic acid supplementation with risk of ventricular septal defect: a case-control study.
    European journal of clinical nutrition, 2022, Volume: 76, Issue:9

    Topics: Case-Control Studies; Dietary Supplements; Female; Folate Receptor 1; Folate Receptor 2; Folic Acid; Genetic Predisposition to Disease; Heart Septal Defects, Ventricular; Humans; Infant; Logistic Models; Polymorphism, Genetic; Risk Factors

2022
Associations of variants of folate cycle genes with features of the clinical course of severe intraventricular hemorrhages in premature infants.
    Journal of neonatal-perinatal medicine, 2022, Volume: 15, Issue:3

    Topics: Case-Control Studies; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Hemorrhage; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Polymorphism, Single Nucleotide

2022
Summary for Patients: Maternal Folate Level and Congenital Heart Disease.
    Annals of internal medicine, 2022, Volume: 175, Issue:9

    Topics: Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans

2022
Association between Methylene-Tetrahydrofolate Reductase C677T Polymorphism and Human Immunodeficiency Virus Type 1 Infection in Morocco.
    Laboratory medicine, 2023, Jan-05, Volume: 54, Issue:1

    Topics: Acquired Immunodeficiency Syndrome; Case-Control Studies; Folic Acid; Genetic Predisposition to Disease; Genotype; HIV Infections; HIV-1; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Morocco; Tetrahydrofolates

2023
Impact of Methionine Synthase Reductase Polymorphisms in Chronic Myeloid Leukemia Patients.
    Genes, 2022, Sep-26, Volume: 13, Issue:10

    Topics: Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Methionine

2022
The Roles of
    Nutrients, 2022, Nov-01, Volume: 14, Issue:21

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Case-Control Studies; Colorectal Neoplasms; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide

2022
Association analysis of MTHFR (rs1801133 and rs1801131) and MTRR (rs1801394) gene polymorphisms towards the development of hypertension in the Bai population from Yunnan, China.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2023, Dec-31, Volume: 45, Issue:1

    Topics: Case-Control Studies; China; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Single Nucleotide

2023
Correlation between single nucleotide polymorphisms of folate metabolism genes and ethnic distribution in pregnant women.
    Medicine, 2023, Jul-28, Volume: 102, Issue:30

    Topics: Adult; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Pregnancy; Pregnant Women; Retrospective Studies; Young Adult

2023
Can the genetic polymorphisms of the folate metabolism have an influence in the polycystic ovary syndrome?
    Archives of endocrinology and metabolism, 2019, Volume: 63, Issue:5

    Topics: Adult; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Polycystic Ovary Syndrome; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Risk Factors; Young Adult

2019
Identifying gene-environment interactions on the efficacy of folic acid therapy for hyperhomocysteinemia based on prediction model.
    Nutrition research (New York, N.Y.), 2020, Volume: 77

    Topics: Aged; Algorithms; Coronary Disease; Female; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Logistic Models; Machine Learning; Male; Middle Aged; Models, Theoretical; Polymorphism, Single Nucleotide; Prospective Studies; Risk Factors; Stroke; Treatment Failure; Treatment Outcome

2020
3'-UTR Polymorphisms of Vitamin B-Related Genes Are Associated with Osteoporosis and Osteoporotic Vertebral Compression Fractures (OVCFs) in Postmenopausal Women.
    Genes, 2020, 06-02, Volume: 11, Issue:6

    Topics: 3' Untranslated Regions; Alleles; Antigens, CD; Female; Folic Acid; Fractures, Compression; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Membrane Transport Proteins; Osteoporosis; Osteoporotic Fractures; Postmenopause; Receptors, Cell Surface; Reduced Folate Carrier Protein; Transcobalamins; Vitamin B 12; Vitamin B Complex

2020
Identification of novel candidate risk genes for myelomeningocele within the glucose homeostasis/oxidative stress and folate/one-carbon metabolism networks.
    Molecular genetics & genomic medicine, 2020, Volume: 8, Issue:11

    Topics: Exome; Folic Acid; Gene Regulatory Networks; Genetic Predisposition to Disease; Glucose; Humans; Meningomyelocele; Oxidative Stress; Polymorphism, Single Nucleotide; Quantitative Trait Loci

2020
A prospective study to explore the relationship between MTHFR C677T genotype, physiological folate levels, and postpartum psychopathology in at-risk women.
    PloS one, 2020, Volume: 15, Issue:12

    Topics: Adult; Alleles; Depression, Postpartum; Female; Folic Acid; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Humans; Longitudinal Studies; Mania; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Postpartum Period; Pregnancy; Prospective Studies; Psychotic Disorders; Risk Factors; Young Adult

2020
Gene Polymorphisms Involved in Folate Metabolism and DNA Methylation with the Risk of Head and Neck Cancer.
    Asian Pacific journal of cancer prevention : APJCP, 2020, 12-01, Volume: 21, Issue:12

    Topics: Biomarkers, Tumor; Brazil; Case-Control Studies; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Female; Folic Acid; Follow-Up Studies; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Head and Neck Neoplasms; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Promoter Regions, Genetic; Risk Factors; Survival Rate; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

2020
Genetic Polymorphisms in DNA Repair Gene APE1/Ref-1 and the Risk of Neural Tube Defects in a High-Risk Area of China.
    Reproductive sciences (Thousand Oaks, Calif.), 2021, Volume: 28, Issue:9

    Topics: Adult; Asian People; Biomarkers; Case-Control Studies; China; DNA-(Apurinic or Apyrimidinic Site) Lyase; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Neural Tube Defects; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Young Adult

2021
Genetically predicted circulating B vitamins in relation to digestive system cancers.
    British journal of cancer, 2021, Volume: 124, Issue:12

    Topics: Adult; Anemia, Pernicious; Case-Control Studies; Digestive System Neoplasms; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Testing; Humans; Male; Mendelian Randomization Analysis; Polymorphism, Single Nucleotide; Risk Factors; Sweden; United Kingdom; Vitamin B 12; Vitamin B 6; Vitamin B Complex; Vitamin B Deficiency

2021
Association of maternal folate use and reduced folate carrier gene polymorphisms with the risk of congenital heart disease in offspring.
    European journal of pediatrics, 2021, Volume: 180, Issue:10

    Topics: Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Mothers; Polymorphism, Genetic; Reduced Folate Carrier Protein; Risk Factors

2021
Cerebral folate transporter deficiency syndrome in three siblings: Why genetic testing for developmental and epileptic encephalopathies should be performed early and include the FOLR1 gene.
    American journal of medical genetics. Part A, 2021, Volume: 185, Issue:8

    Topics: Adolescent; Alleles; Brain; Consanguinity; Developmental Disabilities; Disease Management; Epilepsy; Female; Folate Receptor 1; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Testing; Genotype; Humans; Magnetic Resonance Imaging; Male; Mutation; Neuroaxonal Dystrophies; Phenotype; Siblings; Syndrome; Treatment Outcome

2021
Folate metabolizing gene polymorphisms and genetic vulnerability to preterm birth in Korean women.
    Genes & genomics, 2021, Volume: 43, Issue:8

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alleles; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Placenta; Polymorphism, Single Nucleotide; Polypyrimidine Tract-Binding Protein; Pregnancy; Premature Birth; Republic of Korea; Transcobalamins

2021
Maternal Folic Acid Intake and Methylation Status of Genes Associated with Ventricular Septal Defects in Children: Case-Control Study.
    Nutrients, 2021, Jun-17, Volume: 13, Issue:6

    Topics: Case-Control Studies; Child; Diet; Dietary Supplements; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Heart Defects, Congenital; Heart Septal Defects, Ventricular; Homocystinuria; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Muscle Spasticity; Pregnancy; Prospective Studies; Psychotic Disorders

2021
One-carbon metabolism and global DNA methylation in mothers of individuals with Down syndrome.
    Human cell, 2021, Volume: 34, Issue:6

    Topics: Adolescent; Adult; Aged; Alu Elements; Betaine-Homocysteine S-Methyltransferase; Carbon; DNA Methylation; Down Syndrome; Female; Folic Acid; Genetic Predisposition to Disease; Genome-Wide Association Study; Genomic Instability; Humans; Long Interspersed Nucleotide Elements; Male; Middle Aged; Mother-Child Relations; Mothers; Polymorphism, Genetic; Signal Transduction; Thymidylate Synthase; Transcobalamins; Young Adult

2021
A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis.
    Nature communications, 2021, 08-23, Volume: 12, Issue:1

    Topics: Animals; Blood Urea Nitrogen; Chromatin; Cisplatin; Dipeptidases; DNA Methylation; Ferroptosis; Folic Acid; Gene Editing; Gene Expression Regulation; Genetic Loci; Genetic Predisposition to Disease; Genome-Wide Association Study; Haploinsufficiency; Humans; Iron; Kidney; Kidney Diseases; Mice; Necroptosis; Organ Specificity; Physical Chromosome Mapping; Pyroptosis; Quantitative Trait Loci; RNA, Messenger; Vesicular Transport Proteins

2021
Association of folate metabolism gene polymorphisms and haplotype combination with pulmonary embolism risk in Chinese Han population.
    Mammalian genome : official journal of the International Mammalian Genome Society, 2017, Volume: 28, Issue:5-6

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Asian People; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Pulmonary Embolism; Risk Factors

2017
Association of Three Single Nucleotide Polymorphisms in MTR and MTRR Genes with Lung Cancer in a Turkish Population.
    Genetic testing and molecular biomarkers, 2017, Volume: 21, Issue:7

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Alleles; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Variation; Genotype; Haplotypes; Humans; Lung Neoplasms; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Turkey

2017
Association studies of genetic scores of serum vitamin B12 and folate levels with symptoms of depression and anxiety in two danish population studies.
    European journal of clinical nutrition, 2017, Volume: 71, Issue:9

    Topics: Adolescent; Adult; Aged; Anxiety; Cohort Studies; Denmark; Depressive Disorder; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Mendelian Randomization Analysis; Middle Aged; Psychometrics; Surveys and Questionnaires; Vitamin B 12; White People; Young Adult

2017
An Inframe Trinucleotide Deletion in MTRR Exon 1 is Associated with the Risk of Spina Bifida.
    Neuromolecular medicine, 2017, Volume: 19, Issue:2-3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Amino Acid Sequence; Cells, Cultured; Exons; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Infant, Newborn; Methylation; Models, Molecular; Pregnancy; Pregnancy Complications; Protein Conformation; Recombinant Proteins; Sequence Alignment; Sequence Deletion; Spinal Dysraphism; Young Adult

2017
Association of Human Methionine Synthase-A2756G Transition With Prostate Cancer: A Case-Control Study and in Silico Analysis.
    Acta medica Iranica, 2017, Volume: 55, Issue:5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alleles; Case-Control Studies; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Iran; Male; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Prostatic Neoplasms

2017
Folate, vitamin B12, homocysteine and polymorphisms in folate metabolizing genes in children with congenital heart disease and their mothers.
    European journal of clinical nutrition, 2017, Volume: 71, Issue:12

    Topics: Adult; Case-Control Studies; Child; Child, Preschool; Ferredoxin-NADP Reductase; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Heart Defects, Congenital; Homocysteine; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Polymorphism, Single Nucleotide; Risk Factors; Socioeconomic Factors; Vitamin B 12; Young Adult

2017
Polymorphisms of the folate metabolizing enzymes: Association with SLE susceptibility and in silico analysis.
    Gene, 2017, Dec-30, Volume: 637

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Case-Control Studies; Computer Simulation; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Lupus Erythematosus, Systemic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors; Tetrahydrofolate Dehydrogenase

2017
Mutations in folate transporter genes and risk for human myelomeningocele.
    American journal of medical genetics. Part A, 2017, Volume: 173, Issue:11

    Topics: Alleles; Carrier Proteins; Exons; Female; Folate Receptor 1; Folate Receptor 2; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Meningomyelocele; Mutation; Neural Tube Defects; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Risk Factors

2017
Association Study of Polymorphisms in Genes Relevant to Vitamin B12 and Folate Metabolism with Childhood Autism Spectrum Disorder in a Han Chinese Population.
    Medical science monitor : international medical journal of experimental and clinical research, 2018, Jan-19, Volume: 24

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Alleles; Asian People; Autism Spectrum Disorder; Case-Control Studies; Child; China; Ethnicity; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors; Transcobalamins; Vitamin B 12

2018
Polymorphisms in folate metabolism genes are associated with susceptibility to presbycusis.
    Life sciences, 2018, Mar-01, Volume: 196

    Topics: 3' Untranslated Regions; 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Asian People; Case-Control Studies; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; India; Linkage Disequilibrium; Methylenetetrahydrofolate Reductase (NADPH2); Pilot Projects; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Presbycusis

2018
Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2018, Volume: 34, Issue:4

    Topics: Aminohydrolases; Child; Child, Preschool; China; Female; Ferredoxin-NADP Reductase; Folic Acid; Formate-Tetrahydrofolate Ligase; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Infant; Infant, Newborn; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Neural Tube Defects; Polymorphism, Single Nucleotide; Retrospective Studies

2018
LRP2 gene variants and their haplotypes strongly influence the risk of developing neural tube defects in the fetus: a family-triad study from South India.
    Metabolic brain disease, 2018, Volume: 33, Issue:4

    Topics: Alleles; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; India; Low Density Lipoprotein Receptor-Related Protein-2; Male; Neural Tube Defects; Polymorphism, Genetic; Vitamin B 12

2018
The association between MTHFR polymorphism and cervical cancer.
    Scientific reports, 2018, 05-08, Volume: 8, Issue:1

    Topics: Adult; Alleles; Base Sequence; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Expression; Gene Frequency; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms

2018
Machine learning algorithm-based risk prediction model of coronary artery disease.
    Molecular biology reports, 2018, Volume: 45, Issue:5

    Topics: Adult; Aged; Algorithms; Case-Control Studies; Coronary Artery Disease; Cytochrome P-450 CYP1A1; Epistasis, Genetic; Female; Folic Acid; Forecasting; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Humans; Machine Learning; Male; Middle Aged; Multifactor Dimensionality Reduction; Polymorphism, Single Nucleotide; Risk Factors; Xenobiotics

2018
The Frequency of the 677C>T and 1298A>C Polymorphisms in the Methylenetetrahydrofolate Reductase (MTHFR) Gene in the Population.
    Medical archives (Sarajevo, Bosnia and Herzegovina), 2018, Volume: 72, Issue:3

    Topics: Adolescent; Adult; Aged; Alleles; Bosnia and Herzegovina; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Linkage Disequilibrium; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Restriction Fragment Length; White People; Young Adult

2018
[Case-control study on the association between four single nucleotide polymorphisms in folate metabolism way and the risk of congenital heart disease].
    Wei sheng yan jiu = Journal of hygiene research, 2018, Volume: 47, Issue:4

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Case-Control Studies; Child; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Single Nucleotide; Risk Factors

2018
Association of FOLH1, DHFR, and MTHFR gene polymorphisms with susceptibility of Neural Tube Defects: A case control study from Eastern India.
    Birth defects research, 2018, 08-15, Volume: 110, Issue:14

    Topics: Adult; Alleles; Antigens, Surface; Case-Control Studies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; India; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neural Tube Defects; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors; Tetrahydrofolate Dehydrogenase

2018
Association between increased plasma levels of homocysteine and depression observed in individuals with primary lactose malabsorption.
    PloS one, 2018, Volume: 13, Issue:8

    Topics: Adult; Body Mass Index; Depression; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Homocysteine; Humans; Lactase; Lactose Intolerance; Male; Middle Aged; Risk Factors; Vitamin B 12

2018
Genetic variation in folate metabolism is associated with the risk of conotruncal heart defects in a Chinese population.
    BMC pediatrics, 2018, 08-30, Volume: 18, Issue:1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Asian People; Case-Control Studies; Child, Preschool; China; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein

2018
A case report of branch retinal artery occlusion in a teenager due to hyperhomocysteinaemia; the interplay of genetic and nutritional defects.
    BMC ophthalmology, 2018, Sep-14, Volume: 18, Issue:Suppl 1

    Topics: Adolescent; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Malnutrition; Methylenetetrahydrofolate Reductase (NADPH2); Retinal Artery Occlusion; Vision Disorders; Visual Acuity; Visual Field Tests; Visual Fields; Vitamin B 12; Vitamin B 12 Deficiency

2018
Association of Single Nucleotide Polymorphisms (SNPs) in Genes Encoding for Folate Metabolising Enzymes with Glioma and Meningioma in Indian Population
    Asian Pacific journal of cancer prevention : APJCP, 2018, Dec-25, Volume: 19, Issue:12

    Topics: Adult; Alleles; Asian People; Brain Neoplasms; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Glioma; Humans; India; Male; Meningioma; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide

2018
[The interrelationship of indices of hemocysteine and genetic polymorphisms conditioning disorders of folates metabolism in healthy population].
    Klinicheskaia laboratornaia diagnostika, 2017, Volume: 62, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Risk Factors

2017
Maternal Lactase Polymorphism (rs4988235) Is Associated with Neural Tube Defects in Offspring in the National Birth Defects Prevention Study.
    The Journal of nutrition, 2019, 02-01, Volume: 149, Issue:2

    Topics: Adult; Case-Control Studies; Folic Acid; Folic Acid Deficiency; Genetic Markers; Genetic Predisposition to Disease; Genotype; Hispanic or Latino; Humans; Lactase; Mothers; Neural Tube Defects; Odds Ratio; Polymorphism, Single Nucleotide; United States; Young Adult

2019
Genetic polymorphisms in MTR are associated with non-syndromic congenital heart disease from a family-based case-control study in the Chinese population.
    Scientific reports, 2019, 03-25, Volume: 9, Issue:1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Case-Control Studies; China; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Haplotypes; Heart Diseases; Humans; Inheritance Patterns; Male; Maternal Exposure; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Population Surveillance; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors; Socioeconomic Factors; Young Adult

2019
Prediction model for the efficacy of folic acid therapy on hyperhomocysteinaemia based on genetic risk score methods.
    The British journal of nutrition, 2019, 07-14, Volume: 122, Issue:1

    Topics: Adult; Aged; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Male; Middle Aged; Models, Biological; Polymorphism, Single Nucleotide

2019
Genetic polymorphisms of the cobalamin transport system are associated with idiopathic recurrent implantation failure.
    Journal of assisted reproduction and genetics, 2019, Volume: 36, Issue:7

    Topics: Adult; Alleles; Embryo Implantation; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Polymorphism, Single Nucleotide; Pregnancy; Protein Binding; Receptors, Cell Surface; Transcobalamins; Vitamin B 12

2019
Interactions between genetic variants involved in the folate metabolic pathway and serum lipid, homocysteine levels on the risk of recurrent spontaneous abortion.
    Lipids in health and disease, 2019, Jun-15, Volume: 18, Issue:1

    Topics: Abortion, Spontaneous; Adult; Alleles; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy

2019
Association of MTHFR C677T, MTHFR A1298C, and MTRR A66G Polymorphisms with Neural Tube Defects in Tunisian Parents.
    Pathobiology : journal of immunopathology, molecular and cellular biology, 2019, Volume: 86, Issue:4

    Topics: Alleles; Fathers; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Homocystinuria; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Muscle Spasticity; Neural Tube Defects; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Pregnancy; Psychotic Disorders; Tunisia

2019
Canine breed predispositions for marked hypocobalaminaemia or decreased folate concentration assessed by a laboratory survey.
    The Journal of small animal practice, 2013, Volume: 54, Issue:3

    Topics: Animals; Breeding; Confidence Intervals; Dog Diseases; Dogs; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Male; Odds Ratio; Retrospective Studies; Vitamin B 12; Vitamin B 12 Deficiency

2013
Diet folate, DNA methylation and polymorphisms in methylenetetrahydrofolate reductase in association with the susceptibility to gastric cancer.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Case-Control Studies; Cyclooxygenase 2; Diet; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Folic Acid; Genes, p16; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; MutL Protein Homolog 1; Nuclear Proteins; Polymorphism, Single Nucleotide; Risk Factors; Stomach Neoplasms; Surveys and Questionnaires; Tumor Suppressor Proteins

2013
Plasmatic higher levels of homocysteine in non-alcoholic fatty liver disease (NAFLD).
    Nutrition journal, 2013, Apr-02, Volume: 12

    Topics: Adult; Biomarkers; Brazil; Cholesterol; Chronic Disease; Fatty Liver; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Leukocytes, Mononuclear; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Non-alcoholic Fatty Liver Disease; Polymorphism, Genetic; Triglycerides; Vitamin B 12

2013
Diet influences expression of autoimmune-associated genes and disease severity by epigenetic mechanisms in a transgenic mouse model of lupus.
    Arthritis and rheumatism, 2013, Volume: 65, Issue:7

    Topics: Animals; Antibodies, Antinuclear; Betaine; CD40 Ligand; Choline; Coenzymes; Diet; Disease Models, Animal; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Folic Acid; Gene Silencing; Genetic Predisposition to Disease; Lupus Erythematosus, Systemic; Methionine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Micronutrients; Riboflavin; Vitamin B 12; Vitamin B 6; Zinc

2013
Association of SNPs in genes involved in folate metabolism with the risk of congenital heart disease.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2013, Volume: 26, Issue:18

    Topics: Case-Control Studies; Child; Child, Preschool; Ferredoxin-NADP Reductase; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Methionine Sulfoxide Reductases; Methylenetetrahydrofolate Reductase (NADPH2); Microfilament Proteins; NF-E2-Related Factor 2; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Risk Factors; Transcription Factors

2013
Genome-wide association mapping in dogs enables identification of the homeobox gene, NKX2-8, as a genetic component of neural tube defects in humans.
    PLoS genetics, 2013, Volume: 9, Issue:7

    Topics: Animals; Chromosome Mapping; Dogs; Exons; Folic Acid; Genetic Predisposition to Disease; Genome-Wide Association Study; Homeodomain Proteins; Humans; Linkage Disequilibrium; Mutation; Neural Tube Defects; Transcription Factors

2013
Genetic association of five plasminogen activator inhibitor-1 (PAI-1) polymorphisms and idiopathic recurrent pregnancy loss in Korean women.
    Thrombosis and haemostasis, 2013, Volume: 110, Issue:4

    Topics: Abortion, Habitual; Adult; Blood Coagulation; DNA Mutational Analysis; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Korea; Middle Aged; Mutation; Plasminogen Activator Inhibitor 1; Polymorphism, Genetic; Pregnancy; Young Adult

2013
Perigestational dietary folic acid deficiency protects against medulloblastoma formation in a mouse model of nevoid basal cell carcinoma syndrome.
    Nutrition and cancer, 2013, Volume: 65, Issue:6

    Topics: Animals; Basal Cell Nevus Syndrome; Dietary Supplements; Disease Models, Animal; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Male; Maternal Nutritional Physiological Phenomena; Medulloblastoma; Mice; Mice, Inbred C57BL; Mutation; Patched Receptors; Patched-1 Receptor; Pregnancy; Receptors, Cell Surface

2013
Roles of genetic polymorphisms in the folate pathway in childhood acute lymphoblastic leukemia evaluated by Bayesian relevance and effect size analysis.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: Adolescent; Adult; Bayes Theorem; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Infant; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Minor Histocompatibility Antigens; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Survival Rate; Young Adult

2013
Methylenetetrahydrofolate reductase C677T mutation in patients with alopecia areata in Turkish population.
    Gene, 2013, Nov-01, Volume: 530, Issue:1

    Topics: Adult; Alleles; Alopecia Areata; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Risk Factors; Turkey

2013
Associations of dietary folate, Vitamins B6 and B12 and methionine intake with risk of breast cancer among African American and European American women.
    International journal of cancer, 2014, Mar-15, Volume: 134, Issue:6

    Topics: Adolescent; Adult; Black or African American; Breast Neoplasms; Case-Control Studies; Diet; Female; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Methionine; Middle Aged; Neoplasm Staging; Premenopause; Prognosis; Receptors, Estrogen; Receptors, Progesterone; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamins; White People; Young Adult

2014
Association of dietary intake of folate, vitamin B6 and B12 and MTHFR genotype with breast cancer risk.
    Asian Pacific journal of cancer prevention : APJCP, 2013, Volume: 14, Issue:9

    Topics: Adult; Asian People; Breast Neoplasms; Case-Control Studies; China; Diet; Eating; Female; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Protective Factors; Vitamin B 12; Vitamin B 6

2013
Impact of MTHFR polymorphisms on methylation of MGMT in glioma patients from Northeast China with different folate levels.
    Genetics and molecular research : GMR, 2013, Oct-29, Volume: 12, Issue:4

    Topics: Adult; Alleles; Case-Control Studies; China; DNA Methylation; DNA Modification Methylases; DNA Repair Enzymes; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Glioma; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Tumor Suppressor Proteins

2013
Investigations of single nucleotide polymorphisms in folate pathway genes in Chinese families with neural tube defects.
    Journal of the neurological sciences, 2014, Feb-15, Volume: 337, Issue:1-2

    Topics: Betaine-Homocysteine S-Methyltransferase; China; Family Health; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Single Nucleotide; Signal Transduction

2014
Serum folate, MTHFR C677T polymorphism and esophageal squamous cell carcinoma risk.
    Biomedical and environmental sciences : BES, 2013, Volume: 26, Issue:12

    Topics: Carcinoma, Squamous Cell; Chi-Square Distribution; Esophageal Neoplasms; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic

2013
Analyses of copy number variation reveal putative susceptibility loci in MTX-induced mouse neural tube defects.
    Developmental neurobiology, 2014, Volume: 74, Issue:9

    Topics: Animals; Chromatography, Liquid; Comparative Genomic Hybridization; Disease Models, Animal; DNA Copy Number Variations; Folic Acid; Gene Expression Profiling; Genetic Predisposition to Disease; Leucovorin; Methotrexate; Mice, Inbred C57BL; MicroRNAs; Neural Tube Defects; Real-Time Polymerase Chain Reaction; S-Adenosylmethionine; Tandem Mass Spectrometry; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates

2014
Serum folic acid and RFC A80G polymorphism in Alzheimer's disease and vascular dementia.
    American journal of Alzheimer's disease and other dementias, 2014, Volume: 29, Issue:1

    Topics: Aged; Alzheimer Disease; Case-Control Studies; Dementia, Vascular; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Restriction Fragment Length; Reduced Folate Carrier Protein; Vitamin B 12

2014
Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China.
    Genetics and molecular research : GMR, 2014, Mar-17, Volume: 13, Issue:1

    Topics: Adult; Aminohydrolases; Asian People; Child; China; Down Syndrome; Female; Folic Acid; Formate-Tetrahydrofolate Ligase; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Multienzyme Complexes; Polymorphism, Single Nucleotide; Risk Factors; Transcobalamins

2014
[Study on the relationship between the MTHFR polymorphism, the level of the folic acid and the cervical cancer susceptibility].
    Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2014, Volume: 45, Issue:2

    Topics: Age Factors; Asian People; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Papillomaviridae; Polymorphism, Genetic; Risk Factors; Uterine Cervical Neoplasms

2014
Hyperhomocysteinaemia, low folate concentrations and MTHFR C677T mutation in abdominal aortic aneurysm.
    VASA. Zeitschrift fur Gefasskrankheiten, 2014, Volume: 43, Issue:3

    Topics: Aged; Aged, 80 and over; Aortic Aneurysm, Abdominal; Aortography; Biomarkers; Case-Control Studies; China; Female; Folic Acid; Folic Acid Deficiency; Gene Frequency; Genetic Predisposition to Disease; Heterozygote; Homozygote; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Phenotype; Risk Factors; Tomography, X-Ray Computed; Vitamin B 12

2014
Combined genetic and nutritional risk models of triple negative breast cancer.
    Nutrition and cancer, 2014, Volume: 66, Issue:6

    Topics: Adult; Aged; beta Carotene; Case-Control Studies; Diet; DNA Repair; Energy Intake; Female; Folic Acid; Folic Acid Deficiency; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Logistic Models; Malnutrition; Micronutrients; Middle Aged; Multivariate Analysis; Nutrition Assessment; Pilot Projects; Polymorphism, Single Nucleotide; Risk Factors; Surveys and Questionnaires; Triple Negative Breast Neoplasms; Zinc

2014
Consortium analysis of gene and gene-folate interactions in purine and pyrimidine metabolism pathways with ovarian carcinoma risk.
    Molecular nutrition & food research, 2014, Volume: 58, Issue:10

    Topics: Carcinoma; Case-Control Studies; Diet; Dietary Supplements; Dihydrouracil Dehydrogenase (NADP); Energy Intake; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Genome-Wide Association Study; Global Health; Humans; Multivariate Analysis; Neoplasm Proteins; Ovarian Neoplasms; Polymorphism, Single Nucleotide; Risk Factors; White People

2014
The roles of methylenetetrahydrofolate reductase 677C>T and 1298A>C polymorphisms in moyamoya disease patients.
    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2014, Volume: 30, Issue:10

    Topics: Adolescent; Adult; Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Moyamoya Disease; Nitric Oxide; Polymorphism, Single Nucleotide; Republic of Korea; Vitamin B 12; Young Adult

2014
Association of DNA methyltransferases 3A and 3B polymorphisms, and plasma folate levels with the risk of urothelial carcinoma.
    PloS one, 2014, Volume: 9, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; DNA Methyltransferase 3B; Female; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Smoking; Urologic Neoplasms

2014
Folate-related polymorphisms in gastrointestinal stromal tumours: susceptibility and correlation with tumour characteristics and clinical outcome.
    European journal of human genetics : EJHG, 2015, Volume: 23, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Folic Acid; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Polymorphism, Genetic

2015
Polymorphisms of MTHFR and susceptibility to oesophageal adenocarcinoma in a Caucasian United Kingdom population.
    World journal of gastroenterology, 2014, Sep-14, Volume: 20, Issue:34

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; Cell Differentiation; Chi-Square Distribution; Esophageal Neoplasms; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Staging; Phenotype; Polymorphism, Genetic; Proportional Hazards Models; Risk Assessment; Risk Factors; Time Factors; United Kingdom; White People

2014
Association between dietary intake of folate and MTHFR and MTR genotype with risk of breast cancer.
    Genetics and molecular research : GMR, 2014, Oct-31, Volume: 13, Issue:4

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Breast Neoplasms; Dietary Supplements; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamins

2014
Folate pathway gene polymorphisms, maternal folic acid use, and risk of childhood acute lymphoblastic leukemia.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015, Volume: 24, Issue:1

    Topics: Adolescent; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Infant; Infant, Newborn; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Risk Factors

2015
RFC-1 80G>A polymorphism in case-mother/control-mother dyads is associated with risk of nephroblastoma and neuroblastoma.
    Genetic testing and molecular biomarkers, 2015, Volume: 19, Issue:2

    Topics: Brazil; Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Infant; Infant, Newborn; Kidney Neoplasms; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Neoplasm Proteins; Neuroblastoma; Polymorphism, Single Nucleotide; Replication Protein C; Risk; Wilms Tumor

2015
Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population.
    Journal of assisted reproduction and genetics, 2015, Volume: 32, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Azoospermia; China; Ferredoxin-NADP Reductase; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Infertility, Male; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors

2015
Genetic variants in one-carbon metabolism genes and breast cancer risk in European American and African American women.
    International journal of cancer, 2015, Aug-01, Volume: 137, Issue:3

    Topics: Adult; Alleles; Black People; Breast Neoplasms; Case-Control Studies; Diet; Europe; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Middle Aged; Multifactorial Inheritance; Odds Ratio; Polymorphism, Single Nucleotide; Population Surveillance; Receptors, Estrogen; Risk; Risk Factors; United States

2015
Prevalence of hyperhomocysteinaemia and some of its major determinants in Shaanxi Province, China: a cross-sectional study.
    The British journal of nutrition, 2015, Feb-28, Volume: 113, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; China; Cohort Studies; Cross-Sectional Studies; Female; Folic Acid; Folic Acid Deficiency; Genetic Association Studies; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutrition Surveys; Polymorphism, Genetic; Prevalence; Risk Factors; Young Adult

2015
A potential epigenetic marker mediating serum folate and vitamin B12 levels contributes to the risk of ischemic stroke.
    BioMed research international, 2015, Volume: 2015

    Topics: Case-Control Studies; CpG Islands; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Genetic Markers; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Risk; Stroke; Vitamin B 12

2015
The association of folate pathway and DNA repair polymorphisms with susceptibility to childhood acute lymphoblastic leukemia.
    Gene, 2015, May-15, Volume: 562, Issue:2

    Topics: Case-Control Studies; Child; Child, Preschool; DNA Glycosylases; DNA Mutational Analysis; DNA Repair; DNA-Binding Proteins; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Mutation, Missense; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rad51 Recombinase; Thymidylate Synthase

2015
Association of folate metabolism gene polymorphisms and pulmonary embolism: A case-control study of West-Siberian population.
    Thrombosis research, 2015, Volume: 135, Issue:5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Alleles; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Probability; Pulmonary Embolism; Siberia

2015
Breast cancer risk associated with gene expression and genotype polymorphisms of the folate-metabolizing MTHFR gene: a case-control study in a high altitude Ecuadorian mestizo population.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015, Volume: 36, Issue:8

    Topics: Adult; Aged; Altitude; Biomarkers, Tumor; Breast Neoplasms; Ecuador; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; RNA, Messenger

2015
Folate pathway gene polymorphisms and risk of childhood brain tumors: results from an Australian case-control study.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2015, Volume: 24, Issue:6

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Australia; Biomarkers, Tumor; Brain Neoplasms; Case-Control Studies; Child; Child, Preschool; Dietary Supplements; Female; Ferredoxin-NADP Reductase; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Humans; Incidence; Infant; Infant, Newborn; Male; Methionine Sulfoxide Reductases; Methylenetetrahydrofolate Reductase (NADPH2); Microfilament Proteins; Polymorphism, Single Nucleotide; Prognosis; Risk Factors; Transcription Factors

2015
MTHFR 677C/T and 1298A/C mutations and non-alcoholic fatty liver disease.
    Clinical medicine (London, England), 2015, Volume: 15, Issue:3

    Topics: Adult; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Non-alcoholic Fatty Liver Disease; Vitamin B 12

2015
Study on Environmental Causes and SNPs of MTHFR, MS and CBS Genes Related to Congenital Heart Disease.
    PloS one, 2015, Volume: 10, Issue:6

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Child; Cystathionine beta-Synthase; Environmental Exposure; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Logistic Models; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors

2015
Role of folate-homocysteine pathway gene polymorphisms and nutritional cofactors in Down syndrome: A triad study.
    Human reproduction (Oxford, England), 2015, Volume: 30, Issue:8

    Topics: Adult; Alleles; Diet; Down Syndrome; Female; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Status; Polymorphism, Single Nucleotide; Pregnancy; Risk Factors

2015
Genetic variants in 3'-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans.
    Scientific reports, 2015, Jun-05, Volume: 5

    Topics: 3' Untranslated Regions; Adenocarcinoma; Aged; Colorectal Neoplasms; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Republic of Korea

2015
Gene polymorphisms as risk factors for predicting the cardiovascular manifestations in Marfan syndrome. Role of folic acid metabolism enzyme gene polymorphisms in Marfan syndrome.
    Thrombosis and haemostasis, 2015, Volume: 114, Issue:4

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Aortic Aneurysm; Aortic Dissection; Biomarkers; Case-Control Studies; Chi-Square Distribution; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Heterozygote; Homocysteine; Homozygote; Humans; Logistic Models; Male; Marfan Syndrome; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Predictive Value of Tests; Risk Factors; Severity of Illness Index; Up-Regulation; Vitamin B 12; Young Adult

2015
Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues.
    Epigenetics, 2015, Volume: 10, Issue:8

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Breast; Breast Neoplasms; Carbon; DNA Methylation; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Humans; Long Interspersed Nucleotide Elements; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors

2015
Folate-mediated one-carbon metabolism genes and interactions with nutritional factors on colorectal cancer risk: Women's Health Initiative Observational Study.
    Cancer, 2015, Oct-15, Volume: 121, Issue:20

    Topics: Aged; Biomarkers; Case-Control Studies; Colorectal Neoplasms; DNA-Binding Proteins; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Histone-Lysine N-Methyltransferase; Humans; Logistic Models; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Minor Histocompatibility Antigens; Nuclear Proteins; Polymorphism, Single Nucleotide; Postmenopause; Risk Assessment; Transcription Factors; Vitamin B Complex

2015
3'-UTR Polymorphisms in the MiRNA Machinery Genes DROSHA, DICER1, RAN, and XPO5 Are Associated with Colorectal Cancer Risk in a Korean Population.
    PloS one, 2015, Volume: 10, Issue:7

    Topics: 3' Untranslated Regions; Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; DEAD-box RNA Helicases; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Karyopherins; Male; MicroRNAs; Middle Aged; Polymorphism, Single Nucleotide; ran GTP-Binding Protein; Republic of Korea; Ribonuclease III; Risk; RNA, Neoplasm; Tumor Burden

2015
Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms in oral squamous cell carcinoma in south-east Iran.
    Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology, 2016, Volume: 45, Issue:2

    Topics: Adult; Aged; Alleles; Carcinoma, Squamous Cell; Case-Control Studies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Haplotypes; Head and Neck Neoplasms; Humans; Iran; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mouth Neoplasms; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Risk Factors; Squamous Cell Carcinoma of Head and Neck

2016
Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study.
    Lipids in health and disease, 2015, Sep-04, Volume: 14

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; China; Cross-Sectional Studies; Dyslipidemias; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Expression; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hypertension; Lipoproteins, HDL; Lipoproteins, LDL; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Triglycerides

2015
Polymorphisms in MTHFD1 Gene and Susceptibility to Neural Tube Defects: A Case-Control Study in a Chinese Han Population with Relatively Low Folate Levels.
    Medical science monitor : international medical journal of experimental and clinical research, 2015, Sep-04, Volume: 21

    Topics: Alleles; Brain; Case-Control Studies; China; Computational Biology; Fetus; Folic Acid; Genetic Predisposition to Disease; Haplotypes; High-Throughput Nucleotide Sequencing; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Minor Histocompatibility Antigens; Neural Tube Defects; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Quality Control; Risk Factors; Stillbirth

2015
Polymorphisms of 5,10-methylenetetrahydrofolate reductase and thymidylate synthase, dietary folate intake, and the risk of leukemia in adults.
    Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016, Volume: 37, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Diet; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Leukemia; Leukemia, Myeloid; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Sex Factors; Surveys and Questionnaires; Thymidylate Synthase; Young Adult

2016
High Gestational Folic Acid Supplementation Alters Expression of Imprinted and Candidate Autism Susceptibility Genes in a sex-Specific Manner in Mouse Offspring.
    Journal of molecular neuroscience : MN, 2016, Volume: 58, Issue:2

    Topics: Animals; Autistic Disorder; Cerebral Cortex; Dietary Supplements; DNA Methylation; Female; Folic Acid; Genetic Predisposition to Disease; Genomic Imprinting; Male; Mice; Mice, Inbred C57BL; Pregnancy; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena; Sex Factors; Vitamin B Complex

2016
Coexistence of the 677C>T and 1298A>C MTHFR polymorphisms and its significance in the population of Polish women.
    Ginekologia polska, 2015, Volume: 86, Issue:10

    Topics: Female; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Perinatal Care; Poland; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Pregnancy; Pregnancy Complications; White People

2015
Folate and Prevention of Neural Tube Defects: New Insights from a Bayesian Model.
    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition, 2015, Volume: 85, Issue:3-4

    Topics: Bayes Theorem; Dose-Response Relationship, Drug; Female; Folic Acid; Gene Expression Regulation; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Models, Biological; Neural Tube Defects; Polymorphism, Single Nucleotide; Pregnancy

2015
Dietary folate, one-carbon metabolism-related genes, and gastric cancer risk in Korea.
    Molecular nutrition & food research, 2016, Volume: 60, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Asian People; Carbon; Case-Control Studies; Diet; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Stomach Neoplasms

2016
Association study of the common polymorphisms in the folate-methionine pathway with retinoblastoma.
    Ophthalmic genetics, 2016, Volume: 37, Issue:4

    Topics: Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotyping Techniques; Humans; Iran; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Retinal Neoplasms; Retinoblastoma; Risk Factors; Tandem Repeat Sequences; Thymidylate Synthase

2016
Genetic variants involved in oxidative stress, base excision repair, DNA methylation, and folate metabolism pathways influence myeloid neoplasias susceptibility and prognosis.
    Molecular carcinogenesis, 2017, Volume: 56, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; DNA Methylation; DNA Repair; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Leukemia, Myeloid, Acute; Male; Middle Aged; Myelodysplastic Syndromes; Oxidative Stress; Polymorphism, Single Nucleotide; Prognosis; Signal Transduction; Survival Analysis; Young Adult

2017
Role of MTHFR C677T and MTR A2756G polymorphisms in thyroid and breast cancer development.
    Genetics and molecular research : GMR, 2016, May-09, Volume: 15, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Brazil; Breast Neoplasms; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Thyroid Neoplasms

2016
Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 2016, Volume: 110, Issue:5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Antigens, Surface; Asian People; Cystathionine beta-Synthase; Endemic Diseases; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Glycine Hydroxymethyltransferase; Glycine N-Methyltransferase; Humans; India; Malaria; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Polymorphism, Single Nucleotide; Prevalence; Reduced Folate Carrier Protein; Selection, Genetic

2016
Joint effects of folate intake and one-carbon-metabolizing genetic polymorphisms on breast cancer risk: a case-control study in China.
    Scientific reports, 2016, 07-12, Volume: 6

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Case-Control Studies; China; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic

2016
PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy.
    Scientific reports, 2016, 07-25, Volume: 6

    Topics: Adaptor Proteins, Signal Transducing; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Mercaptopurine; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrophosphatases

2016
Plasma folate, vitamin B-6, and vitamin B-12 and breast cancer risk in BRCA1- and BRCA2-mutation carriers: a prospective study.
    The American journal of clinical nutrition, 2016, Volume: 104, Issue:3

    Topics: Adult; Biomarkers; BRCA1 Protein; BRCA2 Protein; Breast Neoplasms; Cohort Studies; Dietary Supplements; Female; Folic Acid; Follow-Up Studies; Food, Fortified; Genetic Predisposition to Disease; Humans; Incidence; Mutation; Ontario; Prospective Studies; Pyridoxal Phosphate; Risk; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B 6 Deficiency

2016
Sequence variation in folate pathway genes and risks of human cleft lip with or without cleft palate.
    American journal of medical genetics. Part A, 2016, Volume: 170, Issue:11

    Topics: Alleles; California; Case-Control Studies; Cleft Lip; Cleft Palate; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Metabolic Networks and Pathways; Odds Ratio; Polymorphism, Single Nucleotide; Population Surveillance; Risk

2016
Determinants of folate and vitamin B12 plasma levels in the French E3N-EPIC cohort.
    European journal of nutrition, 2018, Volume: 57, Issue:2

    Topics: Amino Acid Substitution; Biomarkers; Case-Control Studies; Cohort Studies; Diet; Diet, Healthy; Female; Folic Acid; Folic Acid Deficiency; France; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nutritional Status; Patient Compliance; Polymorphism, Single Nucleotide; Prospective Studies; Self Report; Vitamin B 12; Vitamin B 12 Deficiency

2018
Gremlin1 plays a key role in kidney development and renal fibrosis.
    American journal of physiology. Renal physiology, 2017, 06-01, Volume: 312, Issue:6

    Topics: Acute Kidney Injury; Animals; Disease Models, Animal; Female; Fibrosis; Folic Acid; Gene Expression Regulation; Genetic Predisposition to Disease; Intercellular Signaling Peptides and Proteins; Kidney Tubules; Mice, Inbred C57BL; Mice, Knockout; Organogenesis; Phenotype; Signal Transduction; Time Factors; Urogenital Abnormalities

2017
Interactions among methylenetetrahydrofolate reductase (MTHFR) and cystathionine β-synthase (CBS) polymorphisms - a cross-sectional study: multiple heterozygosis as a risk factor for higher homocysteine levels and vaso-occlusive episodes.
    Genetics and molecular research : GMR, 2017, Feb-23, Volume: 16, Issue:1

    Topics: Adolescent; Adult; Brazil; Cross-Sectional Studies; Cystathionine beta-Synthase; Epistasis, Genetic; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heterozygote; Homocysteine; Homozygote; Humans; Linkage Disequilibrium; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Thrombophilia; Thrombosis; Vitamin B 12; Young Adult

2017
Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility.
    Circulation, 2017, May-02, Volume: 135, Issue:18

    Topics: Adenosine Triphosphatases; Animals; Asian People; ATPases Associated with Diverse Cellular Activities; Biomarkers; Case-Control Studies; Chi-Square Distribution; Child, Preschool; China; Cyclic AMP Response Element-Binding Protein; Down-Regulation; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Heart Defects, Congenital; HEK293 Cells; Heterozygote; Homozygote; Humans; Introns; Logistic Models; Male; Membrane Transport Proteins; Microtubule-Associated Proteins; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Proteasome Endopeptidase Complex; Protective Factors; Proteolysis; Rats; Risk Assessment; Risk Factors; RNA Interference; Tetrahydrofolate Dehydrogenase; Transcription, Genetic; Transfection

2017
Involvement of ApoE E4 and H63D in sporadic Alzheimer's disease in a folate-supplemented Ontario population.
    Journal of Alzheimer's disease : JAD, 2008, Volume: 14, Issue:1

    Topics: Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoprotein E4; Biomarkers; DNA Mutational Analysis; Erythrocytes; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Genotype; Hemochromatosis; Hemochromatosis Protein; Histocompatibility Antigens Class I; Humans; Iron Overload; Male; Membrane Proteins; Mental Status Schedule; Middle Aged; Ontario; Sex Factors; Vitamin B 12

2008
High plasma homocysteine is associated with the risk of coronary artery disease independent of methylenetetrahydrofolate reductase 677C-->T genotypes.
    Asia Pacific journal of clinical nutrition, 2008, Volume: 17, Issue:2

    Topics: Alleles; Case-Control Studies; Coronary Angiography; Coronary Artery Disease; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Vitamin B 12; Vitamin B 6; Vitamin B Complex

2008
Genetic risk factors and markers for Alzheimer's disease and/or depression in the VITA study.
    Journal of psychiatric research, 2009, Volume: 43, Issue:3

    Topics: Aged; Alzheimer Disease; Apolipoproteins E; Austria; Brain-Derived Neurotrophic Factor; Choline O-Acetyltransferase; Ciliary Neurotrophic Factor; Comorbidity; Depressive Disorder; Educational Status; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Longitudinal Studies; Male; Polymorphism, Genetic; Receptors, Dopamine D4; Risk Factors; Serotonin Plasma Membrane Transport Proteins; Sex Factors

2009
Reduced folate carrier 80A-->G polymorphism, plasma folate, and risk of placental abruption.
    Human genetics, 2008, Volume: 124, Issue:2

    Topics: Abruptio Placentae; Adolescent; Adult; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Membrane Transport Proteins; Middle Aged; Polymorphism, Single Nucleotide; Pregnancy; Reduced Folate Carrier Protein; Risk; Signal Transduction; Smoking

2008
Folate-related gene polymorphisms as risk factors for cleft lip and cleft palate.
    Birth defects research. Part A, Clinical and molecular teratology, 2008, Volume: 82, Issue:9

    Topics: Amino Acid Substitution; Case-Control Studies; Child; Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Multicenter Studies as Topic; Polymorphism, Single Nucleotide; Pregnancy; Risk Factors

2008
[Study on the ingestion of folate and polymorphism of MTHFR C677T with esophageal cancer in Xinjiang Kazakh].
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2008, Volume: 29, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; China; Esophageal Neoplasms; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length

2008
Reduced folate carrier 1 (RFC1) is associated with cleft of the lip only.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2008, Volume: 41, Issue:8

    Topics: Black People; Cleft Lip; Cleft Palate; DNA, Mitochondrial; Female; Folic Acid; Genetic Markers; Genetic Predisposition to Disease; Haplotypes; Humans; Indians, South American; Infant, Newborn; Membrane Transport Proteins; Polymorphism, Genetic; Reduced Folate Carrier Protein; South America; White People

2008
Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects.
    Clinical chemistry and laboratory medicine, 2008, Volume: 46, Issue:10

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Infant; Infant, Newborn; Male; Maternal Behavior; Middle Aged; Mothers; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide; Pregnancy; Smoking; Young Adult

2008
Polymorphisms in folate-related genes and risk of pediatric acute lymphoblastic leukemia.
    Blood, 2009, Mar-05, Volume: 113, Issue:10

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Child; Child, Preschool; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Humans; Infant; Infant, Newborn; Male; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Nicotinamide N-Methyltransferase; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Thymidylate Synthase

2009
Clinical utility of genotyping the 677C>T variant of methylenetetrahydrofolate reductase in humans is decreased in the post-folic acid fortification era.
    The Journal of nutrition, 2009, Volume: 139, Issue:1

    Topics: Adult; Black or African American; Female; Folic Acid; Food, Fortified; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); White People

2009
The impact of folate pathway polymorphisms combined to nutritional deficiency as a maternal predisposition factor for Down syndrome.
    Disease markers, 2008, Volume: 25, Issue:3

    Topics: Adolescent; Adult; Alleles; Case-Control Studies; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Infant, Newborn; Male; Malnutrition; Methylenetetrahydrofolate Reductase (NADPH2); Mothers; Polymorphism, Single Nucleotide; Pregnancy; Risk Factors; Young Adult

2008
Association of reduced folate carrier gene polymorphism and maternal folic acid use with neural tube defects.
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2009, Sep-05, Volume: 150B, Issue:6

    Topics: Adult; Case-Control Studies; Child; Child, Preschool; China; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Infant; Infant, Newborn; Male; Membrane Transport Proteins; Neural Tube Defects; Polymorphism, Genetic; Preconception Care; Reduced Folate Carrier Protein; Risk Factors

2009
Methylenetetrahydrofolate reductase deficiency and low dietary folate reduce tumorigenesis in Apc min/+ mice.
    Gut, 2009, Volume: 58, Issue:6

    Topics: Adenoma; Adenomatous Polyposis Coli Protein; Animals; Apoptosis; Colorectal Neoplasms; Diet; DNA Methylation; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Pregnancy; Prenatal Nutritional Physiological Phenomena; Random Allocation; Thymine Nucleotides; Uridine Triphosphate; Weaning

2009
The expression of folate sensitive fragile sites in patients with bipolar disorder.
    Yonsei medical journal, 2009, Feb-28, Volume: 50, Issue:1

    Topics: Adolescent; Adult; Bipolar Disorder; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human; Cytogenetics; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Young Adult

2009
Lymphocytic mitochondrial DNA deletions, biochemical folate status and hepatocellular carcinoma susceptibility in a case-control study.
    The British journal of nutrition, 2009, Volume: 102, Issue:5

    Topics: Aged; Alanine Transaminase; Alcohol Drinking; Aspartate Aminotransferases; Carcinoma, Hepatocellular; Case-Control Studies; DNA Primers; DNA Probes; DNA, Mitochondrial; Female; Folic Acid; Gene Amplification; Genetic Predisposition to Disease; Humans; Liver Neoplasms; Lymphocytes; Magnetic Resonance Imaging; Male; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Sequence Deletion; Smoking; Taiwan

2009
Dietary intake of folate, vitamin B6, and vitamin B12, genetic polymorphism of related enzymes, and risk of breast cancer: a case-control study in Brazilian women.
    BMC cancer, 2009, Apr-24, Volume: 9

    Topics: Adult; Aged; Brazil; Breast Neoplasms; Case-Control Studies; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Surveys and Questionnaires; Vitamin B 12; Vitamin B 6; Young Adult

2009
Aberrations in folate metabolic pathway and altered susceptibility to autism.
    Psychiatric genetics, 2009, Volume: 19, Issue:4

    Topics: Alleles; Autistic Disorder; Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide

2009
118 SNPs of folate-related genes and risks of spina bifida and conotruncal heart defects.
    BMC medical genetics, 2009, Jun-03, Volume: 10

    Topics: Biological Transport; California; Case-Control Studies; Folic Acid; Genetic Predisposition to Disease; Genotype; Haplotypes; Heart Defects, Congenital; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors; Spinal Dysraphism

2009
Role of thrombotic risk factors in end-stage renal disease.
    Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, 2010, Volume: 16, Issue:2

    Topics: 3' Untranslated Regions; Adult; Alleles; Amino Acid Substitution; Factor V; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation, Missense; Point Mutation; Prothrombin; Risk Factors; Thrombophilia; Vitamin B 12; Young Adult

2010
Evaluation of folate metabolism gene polymorphisms as risk factors for open and closed neural tube defects.
    American journal of medical genetics. Part A, 2009, Volume: 149A, Issue:7

    Topics: DNA Mutational Analysis; Epistasis, Genetic; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Metabolic Networks and Pathways; Neural Tube Defects; Polymorphism, Genetic; Pregnancy; Risk Factors

2009
Relationship between genetic polymorphism, serum folate and homocysteine in Alzheimer's disease.
    Asia-Pacific journal of public health, 2008, Volume: 20 Suppl

    Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide

2008
DHFR 19-bp insertion/deletion polymorphism and MTHFR C677T in adult acute lymphoblastic leukaemia: is the risk reduction due to intracellular folate unbalancing?
    American journal of hematology, 2009, Volume: 84, Issue:8

    Topics: Adult; Aged; Folic Acid; Genetic Predisposition to Disease; Humans; INDEL Mutation; Italy; Methylenetetrahydrofolate Dehydrogenase (NAD+); Middle Aged; Neoplasm Proteins; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Tetrahydrofolate Dehydrogenase

2009
MTHFR polymorphisms, dietary folate intake and breast cancer risk in Chinese women.
    Journal of human genetics, 2009, Volume: 54, Issue:7

    Topics: Adult; Aged; Asian People; Breast Neoplasms; Case-Control Studies; Confidence Intervals; Diet; Feeding Behavior; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide

2009
Dietary folate and vitamin B12 intake before diagnosis decreases gastric cancer mortality risk among susceptible MTHFR 677TT carriers.
    Nutrition (Burbank, Los Angeles County, Calif.), 2010, Volume: 26, Issue:2

    Topics: Adult; Aged; Diet; Diet Surveys; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Middle Aged; Polymorphism, Single Nucleotide; Proportional Hazards Models; Prospective Studies; Risk Factors; Stomach Neoplasms; Surveys and Questionnaires; Survival Analysis; Vitamin B 12; Vitamin B Complex; Young Adult

2010
The relationship between homocysteine and genes of folate-related enzymes in migraine patients.
    Headache, 2010, Volume: 50, Issue:1

    Topics: Adult; Algorithms; DNA Mutational Analysis; Epigenesis, Genetic; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Migraine Disorders; Migraine with Aura; Polymorphism, Genetic; Sex Characteristics; Sex Factors; Thymidylate Synthase

2010
Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer.
    Molecular biology reports, 2010, Volume: 37, Issue:1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Case-Control Studies; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Laryngeal Neoplasms; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Minor Histocompatibility Antigens; Neoplasm Metastasis; Polymorphism, Single Nucleotide

2010
The reduced folate carrier (SLC19A1) c.80G>A polymorphism is associated with red cell folate concentrations among women.
    Annals of human genetics, 2009, Volume: 73, Issue:Pt 5

    Topics: Adolescent; Adult; Child; Erythrocytes; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Membrane Transport Proteins; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Sex Characteristics; Young Adult

2009
Body composition at age 9 years, maternal folate intake during pregnancy and methyltetrahydrofolate reductase (MTHFR) C677T genotype.
    The British journal of nutrition, 2009, Volume: 102, Issue:4

    Topics: Adult; Body Composition; Child; Confounding Factors, Epidemiologic; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Reductase (NADPH2); Obesity; Polymorphism, Genetic; Pregnancy; Pregnancy Trimester, Second; Prospective Studies; Regression Analysis

2009
Plasma levels of B vitamins and colorectal cancer risk: the multiethnic cohort study.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2009, Volume: 18, Issue:8

    Topics: Aged; Alcohol Drinking; C-Reactive Protein; Case-Control Studies; Colorectal Neoplasms; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Vitamin B 6; Vitamin B Complex

2009
Genetic association study of putative functional single nucleotide polymorphisms of genes in folate metabolism and spina bifida.
    American journal of obstetrics and gynecology, 2009, Volume: 201, Issue:4

    Topics: Cystathionine beta-Synthase; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Spinal Dysraphism; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase

2009
Associations of folate and choline metabolism gene polymorphisms with orofacial clefts.
    Journal of medical genetics, 2010, Volume: 47, Issue:12

    Topics: Betaine-Homocysteine S-Methyltransferase; Choline; Choline-Phosphate Cytidylyltransferase; Cleft Lip; Cleft Palate; Databases, Genetic; Epistasis, Genetic; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Metabolic Networks and Pathways; Polymorphism, Single Nucleotide

2010
Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.
    Journal of nutrigenetics and nutrigenomics, 2008, Volume: 1, Issue:4

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Alcohol Drinking; Carcinoma; Case-Control Studies; Colonic Neoplasms; Eating; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Risk Factors

2008
Folate nutritional genetics and risk for hypertension in an elderly population sample.
    Journal of nutrigenetics and nutrigenomics, 2009, Volume: 2, Issue:1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Aged, 80 and over; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Hypertension; Male; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Nutrigenomics; Polymorphism, Single Nucleotide; Population; Reduced Folate Carrier Protein; Risk Factors

2009
Variants of folate metabolism genes and risk of left-sided cardiac defects.
    Birth defects research. Part A, Clinical and molecular teratology, 2010, Volume: 88, Issue:1

    Topics: Betaine-Homocysteine S-Methyltransferase; Child; Child, Preschool; Female; Folic Acid; Gene Expression Regulation, Developmental; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Hypoplastic Left Heart Syndrome; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2)

2010
The genetic background of the curly tail strain confers susceptibility to folate-deficiency-induced exencephaly.
    Birth defects research. Part A, Clinical and molecular teratology, 2010, Volume: 88, Issue:2

    Topics: Animals; Diet; DNA-Binding Proteins; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Inositol; Mice; Mice, Transgenic; Neural Tube Defects; Risk Factors; Transcription Factors

2010
Hyperhomocysteinaemia, low folate concentrations and methylene tetrahydrofolate reductase C677T mutation in acute mesenteric venous thrombosis.
    European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery, 2010, Volume: 39, Issue:4

    Topics: Acute Disease; Adult; Aged; Asian People; Biomarkers; Case-Control Studies; Chi-Square Distribution; China; Chromatography, High Pressure Liquid; Down-Regulation; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Immunoassay; Male; Mesenteric Vascular Occlusion; Mesenteric Veins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Odds Ratio; Phenotype; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Risk Assessment; Risk Factors; Venous Thrombosis; Vitamin B 12; Young Adult

2010
The maternal homocysteine pathway is influenced by riboflavin intake and MTHFR polymorphisms without affecting the risk of orofacial clefts in the offspring.
    European journal of clinical nutrition, 2010, Volume: 64, Issue:3

    Topics: Biomarkers; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Linear Models; Logistic Models; Methylenetetrahydrofolate Reductase (NADPH2); Nutrigenomics; Odds Ratio; Polymorphism, Genetic; Riboflavin; Risk Factors; Surveys and Questionnaires; Vitamin B 12

2010
One-carbon metabolism and CpG island methylator phenotype status in incident colorectal cancer: a nested case-referent study.
    Cancer causes & control : CCC, 2010, Volume: 21, Issue:4

    Topics: Aged; Carbon; Case-Control Studies; Colorectal Neoplasms; CpG Islands; DNA Methylation; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Incidence; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Risk Factors; Sweden; Vitamin B 12

2010
[Study of correlationship between congenital heart disease and 5, 10-methylenetetra hydrofolate reductase gene's polymorphism or folacin intakes].
    Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine], 2009, Volume: 43, Issue:8

    Topics: Case-Control Studies; Child, Preschool; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Pregnancy; Risk Factors

2009
MTHFR C677T and postmenopausal breast cancer risk by intakes of one-carbon metabolism nutrients: a nested case-control study.
    Breast cancer research : BCR, 2009, Volume: 11, Issue:6

    Topics: Aged; Breast Neoplasms; Case-Control Studies; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Postmenopause; Risk Factors; Vitamin B Complex

2009
Variants of folate metabolism genes and the risk of conotruncal cardiac defects.
    Circulation. Cardiovascular genetics, 2008, Volume: 1, Issue:2

    Topics: Cohort Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Phenotype; Polymorphism, Single Nucleotide; Risk Factors

2008
Genes involved with folate uptake and distribution and their association with colorectal cancer risk.
    Cancer causes & control : CCC, 2010, Volume: 21, Issue:4

    Topics: Adult; Aged; Carrier Proteins; Case-Control Studies; Colorectal Neoplasms; Family Health; Female; Folate Receptor 1; Folate Receptors, GPI-Anchored; Folic Acid; gamma-Glutamyl Hydrolase; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Male; Membrane Transport Proteins; Middle Aged; Peptide Synthases; Polymorphism, Single Nucleotide; Receptors, Cell Surface; Reduced Folate Carrier Protein; Registries; Risk Factors; Surveys and Questionnaires

2010
Case-only gene-environment interaction studies: when does association imply mechanistic interaction?
    Genetic epidemiology, 2010, Volume: 34, Issue:4

    Topics: Algorithms; Asthma; Data Interpretation, Statistical; Environment; Female; Folic Acid; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Lung Neoplasms; Male; Models, Genetic; Models, Statistical; Polymorphism, Genetic; Research Design; Risk; Smoking

2010
Role of parental folate pathway single nucleotide polymorphisms in altering the susceptibility to neural tube defects in South India.
    Journal of perinatal medicine, 2010, Volume: 38, Issue:1

    Topics: Adult; Carboxypeptidases; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Humans; India; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Single Nucleotide; Young Adult

2010
Genetic variability in the MTHFR gene and colorectal cancer risk using the colorectal cancer family registry.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:1

    Topics: Biomarkers, Tumor; Case-Control Studies; Colorectal Neoplasms; Diet; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Microsatellite Instability; Middle Aged; Polymorphism, Single Nucleotide; Registries; Risk Factors

2010
Gene-gene interactions in the folate metabolic pathway and the risk of conotruncal heart defects.
    Journal of biomedicine & biotechnology, 2010, Volume: 2010

    Topics: Child; Female; Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Linear Models; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide

2010
Genetic polymorphisms in folate and alcohol metabolism and breast cancer risk: a case-control study in Thai women.
    Breast cancer research and treatment, 2010, Volume: 123, Issue:3

    Topics: Adult; Alcohol Drinking; Arylamine N-Acetyltransferase; Biotransformation; Breast Neoplasms; Case-Control Studies; Ethanol; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Humans; Logistic Models; Middle Aged; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Receptors, Dopamine D2; Receptors, Dopamine D3; Risk Assessment; Risk Factors; Serotonin Plasma Membrane Transport Proteins; Thailand

2010
[Features of allele polymorphism of genes involved in homocysteine and folate metabolism in patients with atherosclerosis of the lower extremity arteries].
    Vestnik khirurgii imeni I. I. Grekova, 2009, Volume: 168, Issue:6

    Topics: Alleles; Atherosclerosis; DNA; Female; Ferredoxin-NADP Reductase; Flavoproteins; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Leg; Male; Middle Aged; Polymerase Chain Reaction; Polymorphism, Genetic; Prognosis; Severity of Illness Index

2009
Hereditary spherocytosis.
    Journal of health, population, and nutrition, 2010, Volume: 28, Issue:1

    Topics: Abdomen; Bangladesh; Child; Dehydration; Diagnosis, Differential; Diarrhea; Female; Folic Acid; Genetic Predisposition to Disease; Hematocrit; Hemoglobins; Hepatomegaly; Humans; Leukocyte Count; Oryza; Sodium Chloride; Spherocytosis, Hereditary; Splenomegaly; Ultrasonography; Vitamin B Complex; Vitamins

2010
[The role of genetic predisposition in the development of cardiovascular diseases (myocardial infarction, ischemic stroke, unstable stenocardia) and its interaction with conventional risk factors].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2009, Volume: 109, Issue:10 Suppl 2

    Topics: Aged; Angina, Unstable; Apolipoproteins E; Cardiovascular Diseases; DNA; Female; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Morbidity; Myocardial Infarction; Peptidyl-Dipeptidase A; Polymerase Chain Reaction; Polymorphism, Genetic; Prognosis; Risk Factors; Russia; Stroke

2009
Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population.
    Journal of neuro-oncology, 2010, Volume: 100, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Central Nervous System Neoplasms; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Germany; Humans; Incidence; Lymphoma; Male; Methionine; Middle Aged; Polymorphism, Single Nucleotide; White People

2010
Nutrigenetic impact of daily folate intake on plasma homocysteine and folate levels in patients with different methylenetetrahydrofolate reductase genotypes.
    European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology, 2010, Volume: 17, Issue:6

    Topics: Biomarkers; Chi-Square Distribution; Dietary Supplements; Drug Administration Schedule; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Israel; Linear Models; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Nutrigenomics; Odds Ratio; Phenotype

2010
Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Colorectal Neoplasms; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Prognosis; Prospective Studies; Risk Factors; Survival Rate

2010
Atopy, asthma, and lung function in relation to folate and vitamin B(12) in adults.
    Allergy, 2010, Volume: 65, Issue:11

    Topics: Adult; Asthma; Cross-Sectional Studies; Diet; Enzyme-Linked Immunosorbent Assay; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Hypersensitivity, Immediate; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Respiratory Function Tests; Vitamin B 12

2010
Methylenetetrahydrofolate reductase C677T gene mutation as risk factor for sudden sensorineural hearing loss: association with plasma homocysteine, folate and cholesterol concentrations.
    The Journal of laryngology and otology, 2010, Volume: 124, Issue:12

    Topics: Adolescent; Adult; Aged; Case-Control Studies; Child; Cholesterol; Cochlea; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Hearing Loss, Sensorineural; Hearing Loss, Sudden; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Risk Factors; Young Adult

2010
Relationship between three polymorphisms of methylenetetrahydrofolate reductase (MTHFR C677T, A1298C, and G1793A) gene and risk of prostate cancer: a case-control study.
    The Prostate, 2010, Nov-01, Volume: 70, Issue:15

    Topics: Adult; Aged; Case-Control Studies; Cystamine; DNA; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Prostate-Specific Antigen; Prostatic Neoplasms; Vitamin B 12

2010
Genetic variation in TYMS in the one-carbon transfer pathway is associated with ovarian carcinoma types in the Ovarian Cancer Association Consortium.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:7

    Topics: Adult; Aged; Biomarkers, Tumor; Carbon-Nitrogen Ligases; Case-Control Studies; Dihydrouracil Dehydrogenase (NADP); DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Minor Histocompatibility Antigens; Ovarian Neoplasms; Polymorphism, Single Nucleotide; Thymidylate Synthase

2010
C677T polymorphism of the methylenetetrahydrofolate reductase gene does not affect folic acid, vitamin B12, and homocysteine serum levels in Turkish children with neural tube defects.
    Genetics and molecular research : GMR, 2010, Jun-22, Volume: 9, Issue:2

    Topics: Adult; Alleles; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Genetic; Turkey; Vitamin B 12

2010
Genetic polymorphism of methylenetetrahydrofolate reductase G1793A, hyperhomocysteinemia, and folate deficiency correlate with ulcerative colitis in central China.
    Journal of gastroenterology and hepatology, 2010, Volume: 25, Issue:6

    Topics: Adult; Alleles; China; Colitis, Ulcerative; DNA; Female; Folic Acid; Folic Acid Deficiency; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Immunoenzyme Techniques; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Polymorphism, Genetic; Prevalence; Vitamin B 12

2010
A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:7

    Topics: Case-Control Studies; Colorectal Neoplasms; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Microsatellite Instability; Middle Aged; Polymorphism, Single Nucleotide; United States; Vitamin B 12

2010
Could genetic analysis be useful in reducing cerebrovascular risk in hypertensive subjects with hyperhomocysteinemia and patent foramen ovale? A 2-year follow-up study.
    Microvascular research, 2010, Volume: 80, Issue:3

    Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Blood Pressure; Cerebrovascular Disorders; Chi-Square Distribution; Echocardiography, Transesophageal; Female; Folic Acid; Follow-Up Studies; Foramen Ovale, Patent; Gene Frequency; Genetic Predisposition to Disease; Heterozygote; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Hypertension; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Polymorphism, Genetic; Risk Assessment; Risk Factors; Time Factors; Treatment Outcome; Ultrasonography, Doppler, Transcranial; Vitamins; Young Adult

2010
Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children.
    Hematological oncology, 2011, Volume: 29, Issue:3

    Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Cohort Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Indonesia; Infant; Infant, Newborn; Male; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors; Xenobiotics

2011
Treatment of cobalamin C (cblC) deficiency during pregnancy.
    Journal of inherited metabolic disease, 2010, Volume: 33 Suppl 3

    Topics: Amino Acid Metabolism, Inborn Errors; Aspirin; Carnitine; Carrier Proteins; Cells, Cultured; Combined Modality Therapy; Diet, Protein-Restricted; DNA Mutational Analysis; Female; Folic Acid; Genetic Predisposition to Disease; Homocystinuria; Humans; Hydroxocobalamin; Live Birth; Male; Mutation; Oxidoreductases; Phenotype; Platelet Aggregation Inhibitors; Pregnancy; Pregnancy Complications; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency; Vitamin B Complex; Young Adult

2010
Variants in folate pathway genes as modulators of genetic instability and lung cancer risk.
    Genes, chromosomes & cancer, 2011, Volume: 50, Issue:1

    Topics: Aged; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Regulatory Networks; Genetic Predisposition to Disease; Genomic Instability; Glycine Hydroxymethyltransferase; Humans; Linkage Disequilibrium; Lung Neoplasms; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Micronucleus Tests; Middle Aged; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Regression Analysis; Tumor Cells, Cultured

2011
Associations of folate, vitamin B12, homocysteine, and folate-pathway polymorphisms with prostate-specific antigen velocity in men with localized prostate cancer.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010, Volume: 19, Issue:11

    Topics: Aged; Biomarkers, Tumor; Disease Progression; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Prostate-Specific Antigen; Prostatic Neoplasms; Signal Transduction; Vitamin B 12

2010
Common polymorphisms in six genes of the methyl group metabolism pathway and obesity in European adolescents.
    International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity, 2011, Volume: 6, Issue:2-2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adiposity; Adolescent; Age Factors; Aryldialkylphosphatase; Biomarkers; Body Mass Index; Case-Control Studies; Chi-Square Distribution; Cystathionine beta-Synthase; Europe; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Linear Models; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Obesity; Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Risk Assessment; Risk Factors; Transcobalamins; Waist Circumference

2011
Maternal polymorphisms in folic acid metabolic genes are associated with nonsyndromic cleft lip and/or palate in the Brazilian population.
    Birth defects research. Part A, Clinical and molecular teratology, 2010, Volume: 88, Issue:11

    Topics: Adolescent; Adult; Brazil; Case-Control Studies; Cleft Lip; Cleft Palate; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Minor Histocompatibility Antigens; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Pregnancy; Reduced Folate Carrier Protein; Risk Factors; Young Adult

2010
C-reactive protein, vitamin B12 and C677T polymorphism of N-5,10-methylenetetrahydrofolate reductase gene are related to insulin resistance and risk factors for metabolic syndrome in Chinese population.
    Clinical and investigative medicine. Medecine clinique et experimentale, 2010, Oct-01, Volume: 33, Issue:5

    Topics: Aged; Asian People; C-Reactive Protein; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Insulin Resistance; Male; Metabolic Syndrome; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Radioimmunoassay; Vitamin B 12

2010
Dietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.
    Cancer causes & control : CCC, 2011, Volume: 22, Issue:1

    Topics: Aged; Colorectal Neoplasms; CpG Islands; Diet; DNA Methylation; Epigenesis, Genetic; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Methionine; Methyltransferases; Middle Aged; Polymerase Chain Reaction; Promoter Regions, Genetic; Vitamin B 6

2011
Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12.
    Cancer causes & control : CCC, 2011, Volume: 22, Issue:1

    Topics: Adult; Aged; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Vitamin B 12; Young Adult

2011
Using biological knowledge to discover higher order interactions in genetic association studies.
    Genetic epidemiology, 2010, Volume: 34, Issue:8

    Topics: Algorithms; Bayes Theorem; Breast Neoplasms; Computer Simulation; Female; Folic Acid; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Linear Models; Metabolic Networks and Pathways; Polymorphism, Single Nucleotide; Risk Factors; Sensitivity and Specificity

2010
Polymorphisms in genes involved in folate metabolism and plasma DNA methylation in colorectal cancer patients.
    Oncology reports, 2011, Volume: 25, Issue:1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adaptor Proteins, Signal Transducing; Biomarkers, Tumor; Colorectal Neoplasms; DNA; DNA Methylation; DNA-Binding Proteins; Female; Folic Acid; Genes, p16; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; MutL Protein Homolog 1; Neoplasm Staging; Nuclear Proteins; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Tumor Protein p73; Tumor Suppressor Proteins

2011
Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer.
    Molecular biology reports, 2011, Volume: 38, Issue:8

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Carbon; Case-Control Studies; Demography; Epistasis, Genetic; Female; Folic Acid; Genetic Loci; Genetic Predisposition to Disease; Humans; Middle Aged; Polymorphism, Genetic; Young Adult

2011
General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child with a congenital heart defect.
    American journal of obstetrics and gynecology, 2011, Volume: 204, Issue:3

    Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug-Related Side Effects and Adverse Reactions; Female; Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Infant; Maternal Exposure; Polymorphism, Genetic; Pregnancy; Prenatal Exposure Delayed Effects; Risk Factors; Surveys and Questionnaires; Vitamin B Complex

2011
Nonsyndromic cleft lip and palate: CRISPLD genes and the folate gene pathway connection.
    Birth defects research. Part A, Clinical and molecular teratology, 2011, Volume: 91, Issue:1

    Topics: Cell Adhesion Molecules; Cleft Lip; Cleft Palate; Folic Acid; Genes; Genetic Predisposition to Disease; Genotype; Hispanic or Latino; Humans; Interferon Regulatory Factors; Polymorphism, Single Nucleotide; White People

2011
NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects.
    Birth defects research. Part A, Clinical and molecular teratology, 2011, Volume: 91, Issue:1

    Topics: Adult; Arylamine N-Acetyltransferase; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Isoenzymes; Male; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide; Risk Factors; Thymidylate Synthase

2011
Folate pathway and nonsyndromic cleft lip and palate.
    Birth defects research. Part A, Clinical and molecular teratology, 2011, Volume: 91, Issue:1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Betaine-Homocysteine S-Methyltransferase; Carbon-Nitrogen Ligases; Cleft Lip; Cleft Palate; Folic Acid; Genes; Genetic Predisposition to Disease; Hispanic or Latino; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Thymidylate Synthase; White People

2011
Variation in folate pathway genes and distal colorectal adenoma risk: a sigmoidoscopy-based case-control study.
    Cancer causes & control : CCC, 2011, Volume: 22, Issue:4

    Topics: Adenoma; Aged; Case-Control Studies; Colorectal Neoplasms; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Models, Biological; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Risk Factors; Sigmoidoscopy

2011
Association between selected folate pathway polymorphisms and nonsyndromic limb reduction defects: a case-parental analysis.
    Paediatric and perinatal epidemiology, 2011, Volume: 25, Issue:2

    Topics: Adolescent; Adult; Body Weight; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Limb Deformities, Congenital; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Pedigree; Poisson Distribution; Polymorphism, Single Nucleotide; Preconception Care; Pregnancy; Risk Factors; Young Adult

2011
Interactions between genetic variants of folate metabolism genes and lifestyle affect plasma homocysteine concentrations in the Boston Puerto Rican population.
    Public health nutrition, 2011, Volume: 14, Issue:10

    Topics: Aged; Alcohol Drinking; Alleles; Boston; Cross-Sectional Studies; Female; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Life Style; Linear Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Motor Activity; Polymorphism, Single Nucleotide; Proton-Coupled Folate Transporter; Puerto Rico; Sex Factors; Smoking; Vitamin B 12

2011
Smoking and polymorphisms in folate metabolizing genes and their effects on the histological stage and grade for bladder tumors.
    Bulletin du cancer, 2011, Volume: 98, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Carcinoma, Transitional Cell; DNA Damage; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasm Staging; Polymorphism, Genetic; Risk; Risk Factors; Smoking; Thymidylate Synthase; Urinary Bladder Neoplasms

2011
Association of MTHFR, MTR, MTRR, RFC1, and DHFR gene polymorphisms with susceptibility to sporadic colon cancer.
    DNA and cell biology, 2011, Volume: 30, Issue:10

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Aged, 80 and over; Alleles; Case-Control Studies; Colonic Neoplasms; Croatia; DNA Fingerprinting; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Male; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Polymorphism, Genetic; Risk Factors; Tetrahydrofolate Dehydrogenase

2011
Association between dietary folate intake and clinical outcome in head and neck squamous cell carcinoma.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2012, Volume: 23, Issue:1

    Topics: Adult; Aged; Carcinoma, Squamous Cell; Cohort Studies; Diet; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Head and Neck Neoplasms; Humans; Kaplan-Meier Estimate; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Minor Histocompatibility Antigens; Polymorphism, Single Nucleotide; Prognosis; Proportional Hazards Models; Retrospective Studies; Reverse Transcriptase Polymerase Chain Reaction; Surveys and Questionnaires; Thymidylate Synthase; Young Adult

2012
Nutrients in folate-mediated, one-carbon metabolism and the risk of rectal tumors in men and women.
    Nutrition and cancer, 2011, Volume: 63, Issue:3

    Topics: Adult; Aged; Case-Control Studies; CpG Islands; Diet; Dietary Supplements; DNA Methylation; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Phenotype; Polymorphism, Genetic; Proto-Oncogene Proteins; Proto-Oncogene Proteins p21(ras); ras Proteins; Rectal Neoplasms; Riboflavin; Risk Factors; Sex Factors; Tumor Suppressor Protein p53; Vitamin B 12; Vitamin B 6

2011
Plasma homocysteine levels, methylene tetrahydrofolate reductase polymorphisms, and the risk of thromboembolism in children.
    Journal of pediatric hematology/oncology, 2011, Volume: 33, Issue:5

    Topics: Adolescent; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Infant; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Prevalence; Reference Values; Risk Factors; Thromboembolism; Vitamin B Complex; Young Adult

2011
The basis of differential responses to folic acid supplementation.
    Journal of nutrigenetics and nutrigenomics, 2011, Volume: 4, Issue:2

    Topics: Aged; Aged, 80 and over; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Models, Genetic; Nutrigenomics; Polymorphism, Single Nucleotide; Twins, Dizygotic; Twins, Monozygotic; Vitamin B 12

2011
Polymorphisms in folate-related genes: impact on risk of adult acute lymphoblastic leukemia rather than pediatric in Han Chinese.
    Leukemia & lymphoma, 2011, Volume: 52, Issue:9

    Topics: Adolescent; Adult; Alleles; Asian People; Child; Child, Preschool; China; Female; Folic Acid; Gene Expression Regulation, Leukemic; Genetic Predisposition to Disease; Genotype; Humans; Male; Metabolic Networks and Pathways; Middle Aged; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Young Adult

2011
Polymorphism C1420T of Serine hydroxymethyltransferase gene on maternal risk for Down syndrome.
    Molecular biology reports, 2012, Volume: 39, Issue:3

    Topics: DNA Primers; Down Syndrome; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Inheritance Patterns; Logistic Models; Methylmalonic Acid; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors

2012
An enhanced risk of basal cell carcinoma is associated with particular polymorphisms in the VDR and MTHFR genes.
    Experimental dermatology, 2011, Volume: 20, Issue:10

    Topics: Adult; Aged; Carcinoma, Basal Cell; Case-Control Studies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Poland; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Receptors, Calcitriol; Risk Factors; Skin; Skin Neoplasms; Ultraviolet Rays; Vitamin D

2011
Genetic variants in the folate pathway and risk of childhood acute lymphoblastic leukemia.
    Cancer causes & control : CCC, 2011, Volume: 22, Issue:9

    Topics: Alcohol Drinking; Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Genotype; Haplotypes; Humans; Infant; Infant, Newborn; Male; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk Factors

2011
Polymorphisms in folate-related enzyme genes in idiopathic infertile Brazilian men.
    Reproductive sciences (Thousand Oaks, Calif.), 2011, Volume: 18, Issue:12

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Azoospermia; Brazil; Case-Control Studies; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Haplotypes; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Phenotype; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Assessment; Risk Factors

2011
Folate supplementation, MTHFR gene polymorphism and neural tube defects: a community based case control study in North India.
    Metabolic brain disease, 2011, Volume: 26, Issue:3

    Topics: Adult; Alleles; Case-Control Studies; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Heterozygote; Humans; India; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Single Nucleotide; Pregnancy; Young Adult

2011
Combined effects of antioxidant vitamin and NOS3 genetic polymorphisms on breast cancer risk in women.
    Clinical nutrition (Edinburgh, Scotland), 2012, Volume: 31, Issue:1

    Topics: Adult; Antioxidants; Asian People; beta Carotene; Breast Neoplasms; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Middle Aged; Nitric Oxide Synthase Type III; Polymorphism, Single Nucleotide; Republic of Korea; Risk Factors; Vitamin E; Vitamins

2012
Methylenetetrahydrofolate reductase gene polymorphisms in children with attention deficit hyperactivity disorder.
    International journal of medical sciences, 2011, Volume: 8, Issue:7

    Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Impulsive Behavior; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Sample Size; Turkey

2011
Folate, alcohol, and aldehyde dehydrogenase 2 polymorphism and the risk of oral and pharyngeal cancer in Japanese.
    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP), 2012, Volume: 21, Issue:2

    Topics: Adult; Aged; Alcohol Drinking; Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Asian People; Carcinoma; Carcinoma, Squamous Cell; Case-Control Studies; Eating; Female; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Head and Neck Neoplasms; Humans; Male; Middle Aged; Mouth Neoplasms; Pharyngeal Neoplasms; Polymorphism, Single Nucleotide; Risk Factors; Squamous Cell Carcinoma of Head and Neck; Young Adult

2012
Association of methylenetetrahydrofolate reductase C677T-A1298C polymorphisms with risk for esophageal adenocarcinoma, Barrett's esophagus, and reflux esophagitis.
    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2012, Volume: 25, Issue:5

    Topics: Adenocarcinoma; Adult; Aged; Barrett Esophagus; Case-Control Studies; Esophageal Neoplasms; Esophagitis, Peptic; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic

2012
Folate metabolism-related gene polymorphisms and susceptibility to primary liver cancer in North China.
    Medical oncology (Northwood, London, England), 2012, Volume: 29, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Asian People; Case-Control Studies; China; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Liver Neoplasms; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Thymidylate Synthase

2012
Evaluation of heterogeneity in the association between congenital heart defects and variants of folate metabolism genes: conotruncal and left-sided cardiac defects.
    Birth defects research. Part A, Clinical and molecular teratology, 2011, Volume: 91, Issue:10

    Topics: Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Humans; Male; Risk Factors

2011
Genetic variation throughout the folate metabolic pathway influences negative symptom severity in schizophrenia.
    Schizophrenia bulletin, 2013, Volume: 39, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Catechol O-Methyltransferase; Cohort Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Glutamate Carboxypeptidase II; Humans; Linear Models; Male; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Mutation, Missense; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index

2013
MTHFR polymorphisms, folate intake and carcinogen DNA adducts in the lung.
    International journal of cancer, 2012, Sep-01, Volume: 131, Issue:5

    Topics: Adenocarcinoma; Aged; Carcinoma, Squamous Cell; Case-Control Studies; DNA Adducts; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Lung; Lung Neoplasms; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasm Staging; Polymorphism, Genetic; Prognosis; Risk Factors; Smoking

2012
Folate and vitamin B12-related genes and risk for omphalocele.
    Human genetics, 2012, Volume: 131, Issue:5

    Topics: Folic Acid; Genetic Predisposition to Disease; Genotype; Hernia, Umbilical; Homocysteine; Humans; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Pilot Projects; Polymorphism, Single Nucleotide; Receptors, Cell Surface; Risk; Vitamin B 12

2012
Associations of polymorphisms of folate cycle enzymes and risk of breast cancer in a Brazilian population are age dependent.
    Molecular biology reports, 2012, Volume: 39, Issue:4

    Topics: 5' Untranslated Regions; Adult; Aged; Aging; Brazil; Breast Neoplasms; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genetics, Population; Humans; Middle Aged; Neoplasm Staging; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Risk Factors

2012
A genetic signature of spina bifida risk from pathway-informed comprehensive gene-variant analysis.
    PloS one, 2011, Volume: 6, Issue:11

    Topics: Alleles; Case-Control Studies; Folic Acid; Gene Expression Profiling; Genetic Predisposition to Disease; Hispanic or Latino; Homocysteine; Humans; Infant, Newborn; Metabolic Networks and Pathways; Models, Genetic; Mutation; Purines; Risk Factors; Spinal Dysraphism; White People

2011
Folate and choline metabolism gene variants in relation to ovarian cancer risk in the Polish population.
    Molecular biology reports, 2012, Volume: 39, Issue:5

    Topics: Cadherins; Case-Control Studies; Choline; Databases, Genetic; DNA Methylation; Epistasis, Genetic; Female; Folic Acid; Gene Frequency; Genes, Neoplasm; Genetic Predisposition to Disease; Humans; Incidence; Metabolic Networks and Pathways; Middle Aged; Ovarian Neoplasms; Poland; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Risk Factors

2012
Methylenetetrahydrofolate reductase genotypes and haplotypes associated with susceptibility to colorectal cancer in an eastern Chinese Han population.
    Genetics and molecular research : GMR, 2011, Dec-14, Volume: 10, Issue:4

    Topics: Aged; Asian People; China; Colorectal Neoplasms; Ethnicity; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Genetics, Population; Haplotypes; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length

2011
Folate intake, methylenetetrahydrofolate reductase polymorphisms, and risk of esophageal cancer.
    Asian Pacific journal of cancer prevention : APJCP, 2011, Volume: 12, Issue:8

    Topics: Alcohol Drinking; Alleles; Asian People; Case-Control Studies; Confidence Intervals; Esophageal Neoplasms; Female; Folic Acid; Gene-Environment Interaction; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Genetic; Risk Factors; Smoking

2011
Effects of the MTHFR C677T polymorphism on prostate specific antigen and prostate cancer.
    Asian Pacific journal of cancer prevention : APJCP, 2011, Volume: 12, Issue:9

    Topics: Aged; Alleles; Binding Sites; Exons; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Prostate-Specific Antigen; Prostatic Neoplasms

2011
Paradoxical role of C1561T glutamate carboxypeptidase II (GCPII) genetic polymorphism in altering disease susceptibility.
    Gene, 2012, Apr-15, Volume: 497, Issue:2

    Topics: Abortion, Spontaneous; Antigens, Surface; Autistic Disorder; Breast Neoplasms; Cohort Studies; Coronary Artery Disease; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Humans; Male; Polymorphism, Genetic; Prostatic Neoplasms

2012
Solute Carrier Family 19, member 1 (SLC19A1) polymorphisms (-43T>C, 80G>A, and 696C>T), and haplotypes in idiopathic recurrent spontaneous abortion in a Korean population.
    Reproductive sciences (Thousand Oaks, Calif.), 2012, Volume: 19, Issue:5

    Topics: Abortion, Habitual; Adult; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Haplotypes; Homocysteine; Humans; Korea; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Pregnancy; Reduced Folate Carrier Protein; Risk Factors

2012
Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studies.
    Cancer causes & control : CCC, 2012, Volume: 23, Issue:4

    Topics: Adult; Aged; Case-Control Studies; Colorectal Neoplasms; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk Factors

2012
Risk of congenital heart defects is influenced by genetic variation in folate metabolism.
    Cardiology in the young, 2013, Volume: 23, Issue:1

    Topics: Aortic Valve Stenosis; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heart Defects, Congenital; Heart Septal Defects, Ventricular; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Phenotype; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein

2013
Serum folate, total homocysteine levels and methylenetetrahydrofolate reductase 677C>T polymorphism in young healthy female Japanese.
    Asia Pacific journal of clinical nutrition, 2012, Volume: 21, Issue:2

    Topics: Adolescent; Amplified Fragment Length Polymorphism Analysis; Child; Diet; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Health Surveys; Homocysteine; Homozygote; Humans; Hyperhomocysteinemia; Japan; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Vascular Diseases; Vitamin B 12; Vitamin B 6

2012
A case-control nutrigenomic study on the synergistic activity of folate and vitamin B12 in cervical cancer progression.
    Nutrition and cancer, 2012, Volume: 64, Issue:4

    Topics: Case-Control Studies; Drug Synergism; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; India; Logistic Models; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Nutrigenomics; Odds Ratio; Polymorphism, Genetic; Risk Assessment; Uterine Cervical Neoplasms; Vitamin B 12; Vitamin B Complex

2012
Solar cycle predicts folate-sensitive neonatal genotypes at discrete phases of the first trimester of pregnancy: a novel folate-related human embryo loss hypothesis.
    Medical hypotheses, 2012, Volume: 79, Issue:2

    Topics: Climate; Embryo Loss; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Models, Biological; Polymorphism, Single Nucleotide; Pregnancy; Pregnancy Trimester, First; Prevalence; Solar Energy; United Kingdom

2012
Folate network genetic variation predicts cardiovascular disease risk in non-Hispanic white males.
    The Journal of nutrition, 2012, Volume: 142, Issue:7

    Topics: Adult; Carbon; Cardiovascular Diseases; Folic Acid; gamma-Glutamyl Hydrolase; Genetic Association Studies; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Regression Analysis; Risk Factors; Thymidylate Synthase; White People

2012
Polymorphism 677C → T MTHFR gene in Mexican mothers of children with complex congenital heart disease.
    Pediatric cardiology, 2013, Volume: 34, Issue:1

    Topics: Adult; Dietary Supplements; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Mothers; Polymorphism, Genetic; Pregnancy; Risk Factors; Surveys and Questionnaires

2013
Folic acid supplementation, MTHFR and MTRR polymorphisms, and the risk of childhood leukemia: the ESCALE study (SFCE).
    Cancer causes & control : CCC, 2012, Volume: 23, Issue:8

    Topics: Case-Control Studies; Child, Preschool; Dietary Supplements; Female; Ferredoxin-NADP Reductase; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Infant, Newborn; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy; Pregnancy Complications

2012
A candidate gene study of one-carbon metabolism pathway genes and colorectal cancer risk.
    The British journal of nutrition, 2013, Mar-28, Volume: 109, Issue:6

    Topics: Aged; Carbon; Case-Control Studies; Colorectal Neoplasms; Diet; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genotype; Humans; Male; Methionine; Mutagenesis, Insertional; Nucleotides; One-Carbon Group Transferases; Polymerase Chain Reaction; Polymorphism, Single Nucleotide; Transcobalamins; Vitamin B 12

2013
Evaluation of common genetic variants in 82 candidate genes as risk factors for neural tube defects.
    BMC medical genetics, 2012, Aug-02, Volume: 13

    Topics: Animals; Case-Control Studies; Disease Models, Animal; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genetic Variation; Humans; Ireland; Mice; Neural Tube Defects; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B 12

2012
Association of COMT, MTHFR, and SLC19A1(RFC-1) polymorphisms with homocysteine blood levels and cognitive impairment in Parkinson's disease.
    Pharmacogenetics and genomics, 2012, Volume: 22, Issue:10

    Topics: Catechol O-Methyltransferase; Cognition Disorders; Female; Folic Acid; Genetic Association Studies; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Parkinson Disease; Polymorphism, Genetic; Reduced Folate Carrier Protein; Vitamin B 12

2012
Maternal and infant gene-folate interactions and the risk of neural tube defects.
    American journal of medical genetics. Part A, 2012, Volume: 158A, Issue:10

    Topics: Adult; Case-Control Studies; Dietary Supplements; Female; Folic Acid; Gene-Environment Interaction; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Infant, Newborn; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Dehydrogenase (NADP); Minor Histocompatibility Antigens; Neural Tube Defects; Polymorphism, Single Nucleotide; Proteins; Risk Factors; Young Adult

2012
A case-parent triad assessment of folate metabolic genes and the risk of childhood acute lymphoblastic leukemia.
    Cancer causes & control : CCC, 2012, Volume: 23, Issue:11

    Topics: Case-Control Studies; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Polymorphism, Single Nucleotide; Precursor Cell Lymphoblastic Leukemia-Lymphoma

2012
Association of dietary and genetic factors related to one-carbon metabolism with global methylation level of leukocyte DNA.
    Cancer science, 2012, Volume: 103, Issue:12

    Topics: Adult; Aged; Carbon; Case-Control Studies; Cross-Sectional Studies; Diet; DNA Methylation; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Leukocytes; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Vitamin B 12; Vitamin B 6; Vitamins

2012
Gene-diet-interactions in folate-mediated one-carbon metabolism modify colon cancer risk.
    Molecular nutrition & food research, 2013, Volume: 57, Issue:4

    Topics: Adult; Aged; Case-Control Studies; Colonic Neoplasms; Diet; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Humans; Male; Methionine; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Minor Histocompatibility Antigens; Polymorphism, Genetic; Riboflavin; Risk Factors; Vitamin B 12; Vitamin B 6

2013
Methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Moroccan women.
    African health sciences, 2012, Volume: 12, Issue:2

    Topics: Adult; Alleles; Black People; Breast Neoplasms; Case-Control Studies; Confidence Intervals; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Menopause; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Morocco; Odds Ratio; Polymorphism, Restriction Fragment Length; Receptors, Progesterone; Risk Factors; Spectrophotometry

2012
Idiopathic pulmonary fibrosis and polymorphisms of the folate pathway genes.
    Clinical biochemistry, 2013, Volume: 46, Issue:1-2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Haplotypes; Humans; Idiopathic Pulmonary Fibrosis; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Minor Histocompatibility Antigens; Polymorphism, Single Nucleotide; Tetrahydrofolate Dehydrogenase; Transcobalamins

2013
Association of the miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with ischemic stroke and silent brain infarction risk.
    Arteriosclerosis, thrombosis, and vascular biology, 2013, Volume: 33, Issue:2

    Topics: Aged; Biomarkers; Brain Infarction; Brain Ischemia; Case-Control Studies; Chi-Square Distribution; Epistasis, Genetic; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Homocysteine; Humans; Logistic Models; Magnetic Resonance Imaging; Male; MicroRNAs; Middle Aged; Multivariate Analysis; Odds Ratio; Phenotype; Polymerase Chain Reaction; Polymorphism, Genetic; Prevalence; Republic of Korea; Risk Assessment; Risk Factors

2013
Folate metabolism gene 5,10-methylenetetrahydrofolate reductase (MTHFR) is associated with ADHD in myelomeningocele patients.
    PloS one, 2012, Volume: 7, Issue:12

    Topics: Attention Deficit Disorder with Hyperactivity; Behavior; Case-Control Studies; Child; Female; Folic Acid; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; Genome, Human; Haplotypes; Hispanic or Latino; Humans; Linkage Disequilibrium; Male; Meningomyelocele; Metabolic Networks and Pathways; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; White People

2012
Folate metabolism genes, dietary folate and response to antidepressant medications in late-life depression.
    International journal of geriatric psychiatry, 2013, Volume: 28, Issue:9

    Topics: Age of Onset; Aged; Antidepressive Agents; Cystathionine beta-Synthase; Depressive Disorder; Diet; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Predictive Value of Tests; Selective Serotonin Reuptake Inhibitors

2013
The effect of folate-related SNPs on clinicopathological features, response to neoadjuvant treatment and survival in pre- and postmenopausal breast cancer patients.
    Gene, 2013, Apr-15, Volume: 518, Issue:2

    Topics: Adult; Breast Neoplasms; Disease-Free Survival; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Minor Histocompatibility Antigens; Neoadjuvant Therapy; Polymorphism, Single Nucleotide; Postmenopause; Premenopause; Risk

2013
Investigating multiple candidate genes and nutrients in the folate metabolism pathway to detect genetic and nutritional risk factors for lung cancer.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Aged; Alcohol Drinking; Bayes Theorem; Betaine; Case-Control Studies; Choline; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Humans; Lung Neoplasms; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Risk Factors; Smoking; Vitamin B Complex

2013
[Genetic differences in enzymes of folic acid metabolism in patients with lip-jaw-palate clefts and their relatives].
    Mund-, Kiefer- und Gesichtschirurgie : MKG, 2002, Volume: 6, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Arylamine N-Acetyltransferase; Child; Child, Preschool; Cleft Lip; Cleft Palate; DNA Mutational Analysis; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Humans; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Reference Values; Risk

2002
Does prenatal screening for 5,10-methylenetetrahydrofolate reductase (MTHFR) mutations in high-risk neural tube defect pregnancies make sense?
    Genetic testing, 2002,Spring, Volume: 6, Issue:1

    Topics: Animals; Female; Fetal Diseases; Folic Acid; Genetic Predisposition to Disease; Genetic Testing; Homocysteine; Humans; Meta-Analysis as Topic; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; Mutation; Neural Tube Defects; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy; Prenatal Diagnosis

2002
Methylenetetrahydrofolate reductase gene C677T polymorphism, plasma homocysteine and folate in end-stage renal disease dialysis and non-dialysis patients.
    Nephron, 2002, Volume: 92, Issue:1

    Topics: Adolescent; Adult; Age Factors; Disease Progression; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Kidney Failure, Chronic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Single Nucleotide; Renal Dialysis; Risk Factors

2002
Influence of a glutamate carboxypeptidase II (GCPII) polymorphism (1561C-->T) on plasma homocysteine, folate and vitamin B(12) levels and its relationship to cardiovascular disease risk.
    Atherosclerosis, 2002, Volume: 164, Issue:2

    Topics: Adult; Analysis of Variance; Antigens, Surface; Carboxypeptidases; Cardiovascular Diseases; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Glutamate Carboxypeptidase II; Homocysteine; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic; Probability; Reference Values; Risk Assessment; Sensitivity and Specificity; Vitamin B 12

2002
Essential hypertension in adolescents: association with insulin resistance and with metabolism of homocysteine and vitamins.
    American journal of hypertension, 2002, Volume: 15, Issue:10 Pt 1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Cystathionine beta-Synthase; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hypertension; Insulin Resistance; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Prevalence; Risk Factors; Vitamin B 12; Vitamin B 6

2002
Expression of folate sensitive and aphidicolin induced chromosomal fragile sites in familial neuroblastoma.
    Journal of experimental & clinical cancer research : CR, 2002, Volume: 21, Issue:3

    Topics: Aphidicolin; Case-Control Studies; Cells, Cultured; Child, Preschool; Chromosome Aberrations; Chromosome Banding; Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 2; Enzyme Inhibitors; Female; Folic Acid; Genetic Predisposition to Disease; Hematinics; Humans; Infant; Karyotyping; Lymphocytes; Male; Neuroblastoma; Pedigree

2002
Will feeding mothers prevent the Asian metabolic syndrome epidemic?
    Asia Pacific journal of clinical nutrition, 2002, Volume: 11 Suppl 3

    Topics: Adult; Asia; Diet; Dietary Supplements; Disease Outbreaks; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Infant, Low Birth Weight; Infant, Newborn; Metabolic Syndrome; Nutrition Disorders; Nutritional Requirements; Pregnancy; Pregnancy Complications; Prenatal Exposure Delayed Effects; Prenatal Nutritional Physiological Phenomena

2002
Associations between polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and susceptibility to malignant lymphoma.
    Haematologica, 2003, Volume: 88, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Data Interpretation, Statistical; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Humans; Lymphoma; Male; Middle Aged; Polymorphism, Genetic; Thymidylate Synthase

2003
Methylenetetrahydrofolate reductase polymorphism C677T is not associated to the risk of cervical dysplasia.
    Cancer letters, 2003, Mar-10, Volume: 191, Issue:2

    Topics: Adult; Case-Control Studies; Cohort Studies; DNA Methylation; DNA Primers; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Microsatellite Repeats; Middle Aged; Neoplasm Invasiveness; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Polymorphism, Genetic; Retrospective Studies; Risk Factors; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms; Vaginal Smears

2003
Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults.
    Blood, 2003, Apr-01, Volume: 101, Issue:7

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Cystathionine beta-Synthase; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Nutritional Status; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Vitamin B 12

2003
A common variant of the methylenetetrahydrofolate reductase gene (1p36) is associated with an increased risk of cancer.
    Cancer research, 2003, Mar-15, Volume: 63, Issue:6

    Topics: Aged; Aged, 80 and over; Alcohol Drinking; Chromosomes, Human, Pair 1; Cohort Studies; Diet; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Genotype; Humans; Longitudinal Studies; Male; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Oxidoreductases Acting on CH-NH Group Donors; Prospective Studies; Smoking

2003
Genetic evidence that nitric oxide modulates homocysteine: the NOS3 894TT genotype is a risk factor for hyperhomocystenemia.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Jun-01, Volume: 23, Issue:6

    Topics: Adult; Amino Acid Substitution; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation, Missense; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Northern Ireland; Point Mutation; Prospective Studies; Risk Factors; Vitamin B 12

2003
Commentary: Colon cancer, folate and genetic status.
    International journal of epidemiology, 2003, Volume: 32, Issue:1

    Topics: Colonic Neoplasms; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Nutritional Physiological Phenomena; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic

2003
Folate status, genomic DNA hypomethylation, and risk of colorectal adenoma and cancer: a case control study.
    Gastroenterology, 2003, Volume: 124, Issue:5

    Topics: Adenoma; Aged; Case-Control Studies; Colorectal Neoplasms; DNA Methylation; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Risk Factors

2003
Exploring the effects of methylenetetrahydrofolate reductase gene variants C677T and A1298C on the risk of orofacial clefts in 261 Norwegian case-parent triads.
    American journal of epidemiology, 2003, Jun-15, Volume: 157, Issue:12

    Topics: Adolescent; Adult; Alanine; Case-Control Studies; Cleft Lip; Cleft Palate; Cysteine; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Haplotypes; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Norway; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Registries; Risk Factors; Threonine

2003
Evaluation of infant methylenetetrahydrofolate reductase genotype, maternal vitamin use, and risk of high versus low level spina bifida defects.
    Birth defects research. Part A, Clinical and molecular teratology, 2003, Volume: 67, Issue:3

    Topics: California; Case-Control Studies; Dietary Supplements; DNA; Female; Folic Acid; Genetic Predisposition to Disease; Genome, Human; Genotype; Humans; Infant, Newborn; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Polymerase Chain Reaction; Pregnancy; Risk; Spinal Dysraphism

2003
Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event.
    Molecular genetics and metabolism, 2003, Volume: 79, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Alleles; Data Interpretation, Statistical; Ferredoxin-NADP Reductase; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Nutritional Status; Point Mutation; Polymorphism, Single Nucleotide; Prevalence; Reverse Transcriptase Polymerase Chain Reaction; Thromboembolism; Vitamin B 12; Vitamin B 12 Deficiency

2003
The 2756A>G variant in the gene encoding methionine synthase: its relation with plasma homocysteine levels and risk of coronary heart disease in a Dutch case-control study.
    Thrombosis research, 2003, May-01, Volume: 110, Issue:2-3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenine; Case-Control Studies; Coronary Disease; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetic Variation; Genotype; Guanine; Homocysteine; Humans; Middle Aged; Osmolar Concentration; Risk Factors; Vitamin B 12

2003
Methionine synthase (MTR) 2756 (A --> G) polymorphism, double heterozygosity methionine synthase 2756 AG/methionine synthase reductase (MTRR) 66 AG, and elevated homocysteinemia are three risk factors for having a child with Down syndrome.
    American journal of medical genetics. Part A, 2003, Sep-01, Volume: 121A, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Alleles; Case-Control Studies; Child; Down Syndrome; Female; Ferredoxin-NADP Reductase; Flavoproteins; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heterozygote; Homocysteine; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Sicily

2003
Homocysteine status and polymorphisms of methylenetetrahydrofolate reductase are not associated with restenosis after stenting in coronary arteries.
    Arteriosclerosis, thrombosis, and vascular biology, 2003, Volume: 23, Issue:12

    Topics: Aged; Coronary Artery Disease; Coronary Restenosis; Female; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Postoperative Complications; Prosthesis Implantation; Stents; Thrombosis; Treatment Outcome; Vitamin B 12

2003
ACOG practice bulletin. Neural tube defects. Number 44, July 2003. (Replaces committee opinion number 252, March 2001).
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2003, Volume: 83, Issue:1

    Topics: alpha-Fetoproteins; Biomarkers; Delivery, Obstetric; Female; Fetus; Folic Acid; Genetic Predisposition to Disease; Humans; Mass Screening; Neural Tube Defects; Neuroprotective Agents; Pregnancy; Prenatal Diagnosis

2003
[Hyperhomocysteinemia and deep-vein thrombosis].
    Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae, 2003, Volume: 25, Issue:6

    Topics: Adult; Aged; Aged, 80 and over; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Restriction Fragment Length; Venous Thrombosis; Vitamin B 12

2003
Folate and vitamin E deficiency impair cognitive performance in mice subjected to oxidative stress: differential impact on normal mice and mice lacking apolipoprotein E.
    Neuromolecular medicine, 2003, Volume: 4, Issue:3

    Topics: Aging; Animals; Apolipoproteins E; Cognition Disorders; Disease Models, Animal; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Maze Learning; Mice; Mice, Knockout; Neurodegenerative Diseases; Oxidative Stress; Vitamin E; Vitamin E Deficiency

2003
MTHFR polymorphisms, dietary folate intake, and breast cancer risk: results from the Shanghai Breast Cancer Study.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2004, Volume: 13, Issue:2

    Topics: Adult; Breast Neoplasms; Case-Control Studies; China; Diet; DNA Methylation; DNA Repair; Epidemiologic Studies; Female; Folic Acid; Genetic Predisposition to Disease; Hematinics; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Assessment

2004
Gene-gene interaction in folate-related genes and risk of neural tube defects in a UK population.
    Journal of medical genetics, 2004, Volume: 41, Issue:4

    Topics: Case-Control Studies; Epistasis, Genetic; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Neural Tube Defects; Polymorphism, Genetic; United Kingdom

2004
Interaction between genetic variations in DNA repair genes and plasma folate on breast cancer risk.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2004, Volume: 13, Issue:4

    Topics: Adult; Breast Neoplasms; Case-Control Studies; DNA Repair; DNA-Binding Proteins; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Incidence; Middle Aged; Nurses; Polymorphism, Genetic; Prospective Studies; Registries; Risk Factors; Surveys and Questionnaires; United States; X-ray Repair Cross Complementing Protein 1

2004
[Relations of methionine synthase gene variation with congenital heart disease].
    Wei sheng yan jiu = Journal of hygiene research, 2004, Volume: 33, Issue:1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Child; Child, Preschool; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Genotype; Glutathione; Heart Defects, Congenital; Heart Septal Defects; Homocysteine; Humans; Infant; Male; Polymorphism, Genetic; Vitamin B 12

2004
Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study.
    Carcinogenesis, 2004, Volume: 25, Issue:9

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Diet; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Smoking; Urinary Bladder; Urinary Bladder Neoplasms

2004
The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma.
    British journal of cancer, 2004, May-17, Volume: 90, Issue:10

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Case-Control Studies; Cell Transformation, Neoplastic; Central Nervous System Neoplasms; DNA, Neoplasm; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Lymphoma; Male; Middle Aged; Odds Ratio; Polymorphism, Genetic

2004
No association between MTHFR 677 C->T or 1298 A->C polymorphisms and endometrial cancer risk.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2004, Volume: 13, Issue:6

    Topics: Alcohol Drinking; Case-Control Studies; Endometrial Neoplasms; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Methylenetetrahydrofolate Reductase (NADPH2); Nurses; Polymorphism, Genetic; Risk Factors; Vitamins

2004
Clopidogrel resistance marks recurrent risks.
    Circulation, 2004, Jun-29, Volume: 109, Issue:25

    Topics: Aged; Bibliometrics; Cardiology; Clopidogrel; Cohort Studies; Coronary Restenosis; Drug Resistance; Estrogen Receptor alpha; Female; Folic Acid; Genetic Predisposition to Disease; Heart Diseases; Humans; Male; Mass Screening; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Platelet Aggregation Inhibitors; Predictive Value of Tests; Recurrence; Risk; Stents; Ticlopidine; Vitamin B 12; Vitamin B 6

2004
[Study on reduced folate carrier gene (RFC1) polymorphism in the southern and northern Chinese population].
    Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi, 2004, Volume: 25, Issue:6

    Topics: Alleles; Carrier Proteins; China; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Membrane Proteins; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Neural Tube Defects; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length

2004
Methylenetetrahydrofolate reductase 677 C-->T polymorphism and plasma folate in relation to pre-eclampsia risk among Peruvian women.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2004, Volume: 15, Issue:5

    Topics: Adult; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Peru; Point Mutation; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Risk Factors; Surveys and Questionnaires

2004
Stroke and recurrent pregnancy loss due to hyperhomocysteinaemia.
    European journal of neurology, 2005, Volume: 12, Issue:3

    Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Abortion, Habitual; Brain; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Infarction, Middle Cerebral Artery; Middle Aged; Mutation; Platelet Aggregation Inhibitors; Pregnancy; Stroke; Treatment Outcome; Vitamin B 12

2005
One-carbon metabolism, MTHFR polymorphisms, and risk of breast cancer.
    Cancer research, 2005, Feb-15, Volume: 65, Issue:4

    Topics: Aged; Breast Neoplasms; Case-Control Studies; Diet; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; New York; Risk Factors; Vitamin B Complex

2005
MTX-induced white matter changes are associated with polymorphisms of methionine metabolism.
    Neurology, 2005, Mar-08, Volume: 64, Issue:5

    Topics: Aged; Brain; Central Nervous System Neoplasms; Demyelinating Diseases; DNA Mutational Analysis; Drug Resistance; Female; Folic Acid; Folic Acid Antagonists; Gene Frequency; Genetic Predisposition to Disease; Genetic Testing; Haplotypes; Humans; Lymphoma; Male; Methionine; Methotrexate; Middle Aged; Myelin Sheath; Nerve Fibers, Myelinated; Neurotoxins; Polymorphism, Genetic; Risk Factors; S-Adenosylmethionine

2005
Late-onset thrombocytic microangiopathy caused by cblC disease: association with a factor H mutation.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2005, Volume: 45, Issue:3

    Topics: Anemia; Betaine; Child; Combined Modality Therapy; Complement Factor H; Drug Therapy, Combination; Endothelium, Vascular; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Haptoglobins; Hemolytic-Uremic Syndrome; Humans; Hydroxocobalamin; Hypertension; Kidney; Methylenetetrahydrofolate Reductase (NADPH2); Mutation, Missense; Nephrotic Syndrome; Plasma Exchange; Point Mutation; Proteinuria; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-cbl; Renal Dialysis; Vitamin B 12

2005
Cerebral folate deficiency with developmental delay, autism, and response to folinic acid.
    Neurology, 2005, Mar-22, Volume: 64, Issue:6

    Topics: Adaptation, Physiological; Autistic Disorder; Cerebral Cortex; Child; Developmental Disabilities; Disease Progression; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Intellectual Disability; Leucovorin; Mutation; Recovery of Function; Reduced Folate Carrier Protein; Seizures; Tetrahydrofolates; Transcription Factors; Treatment Outcome

2005
Basal cell carcinoma and variants in genes coding for immune response, DNA repair, folate and iron metabolism.
    Mutation research, 2005, Jul-01, Volume: 574, Issue:1-2

    Topics: Carcinoma, Basal Cell; Case-Control Studies; Cohort Studies; DNA Repair; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Interleukins; Iron; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Skin Neoplasms

2005
Polymorphisms in folate metabolic genes and lung cancer risk in Xuan Wei, China.
    Lung cancer (Amsterdam, Netherlands), 2005, Volume: 49, Issue:3

    Topics: Adult; Aged; Alleles; China; Cystathionine beta-Synthase; Female; Folic Acid; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Genetic Variation; Haplotypes; Homozygote; Humans; Lung Neoplasms; Male; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Risk; Smoking

2005
Interaction between maternal periconceptional supplementation of folic acid and reduced folate carrier gene polymorphism of neural tube defects.
    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2005, Volume: 22, Issue:3

    Topics: Adult; Case-Control Studies; Child; Child, Preschool; Dietary Supplements; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Membrane Transport Proteins; Neural Tube Defects; Polymorphism, Genetic; Reduced Folate Carrier Protein; Vitamin B Complex

2005
Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele.
    Brain research. Molecular brain research, 2005, Sep-13, Volume: 139, Issue:1

    Topics: Adult; Case-Control Studies; Female; Folic Acid; Formate-Tetrahydrofolate Ligase; Genetic Predisposition to Disease; Humans; Methenyltetrahydrofolate Cyclohydrolase; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Migraine Disorders; Polymorphism, Genetic; Promoter Regions, Genetic; Risk Factors; Tandem Repeat Sequences; Thymidylate Synthase

2005
Genetic variation of infant reduced folate carrier (A80G) and risk of orofacial defects and congenital heart defects in China.
    Annals of epidemiology, 2006, Volume: 16, Issue:5

    Topics: Case-Control Studies; China; Cleft Lip; Cleft Palate; Folic Acid; Genetic Predisposition to Disease; Heart Defects, Congenital; Humans; Membrane Transport Proteins; Polymorphism, Genetic; Reduced Folate Carrier Protein; Risk; Vitamin B Complex

2006
Methylenetetrahydrofolate reductase polymorphisms and the risk of gestational hypertension.
    Epidemiology (Cambridge, Mass.), 2005, Volume: 16, Issue:5

    Topics: Adult; Alleles; Canada; Case-Control Studies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hypertension, Pregnancy-Induced; Infant, Newborn; Logistic Models; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Prevalence; Risk Factors; United States

2005
MTHFR genetic polymorphisms and susceptibility to childhood acute lymphoblastic leukemia.
    Blood, 2005, Oct-01, Volume: 106, Issue:7

    Topics: Alleles; Case-Control Studies; Child; Child, Preschool; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Infant; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Risk; Risk Factors

2005
[Assessment of metabolic atherosclerosis risk factors in progeny of patients with past ischemic stroke].
    Polskie Archiwum Medycyny Wewnetrznej, 2005, Volume: 113, Issue:2

    Topics: Adult; Apolipoprotein A-I; Apolipoproteins B; Biomarkers; Brain Ischemia; C-Reactive Protein; Case-Control Studies; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; Female; Fibrinogen; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Life Style; Lipoprotein(a); Male; Risk Factors; Stroke; Time Factors; Triglycerides; von Willebrand Factor

2005
Genetic variation of folate-mediated one-carbon transfer pathway predicts susceptibility to choline deficiency in humans.
    Proceedings of the National Academy of Sciences of the United States of America, 2005, Nov-01, Volume: 102, Issue:44

    Topics: Adult; Aged; Carbon; Choline; Choline Deficiency; Female; Folic Acid; Genetic Predisposition to Disease; Heterozygote; Humans; Male; Methylenetetrahydrofolate Dehydrogenase (NADP); Middle Aged; Polymorphism, Genetic; Premenopause

2005
Nutrigenetics in cancer research--folate metabolism and colorectal cancer.
    The Journal of nutrition, 2005, Volume: 135, Issue:11

    Topics: Colorectal Neoplasms; Diet; DNA Methylation; Folic Acid; Genetic Predisposition to Disease; Humans; Nutritional Physiological Phenomena; Pharmacogenetics; Polymorphism, Genetic

2005
A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida.
    Molecular genetics and metabolism, 2006, Volume: 87, Issue:1

    Topics: Adult; California; Case-Control Studies; Cohort Studies; Dietary Supplements; Folic Acid; Genetic Predisposition to Disease; Hispanic or Latino; Humans; Infant, Newborn; Polymorphism, Genetic; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Risk; Spinal Dysraphism; White People

2006
The influence of genetic and environmental factors on plasma homocysteine concentrations in a population at high risk for coronary artery disease.
    Annals of clinical biochemistry, 2005, Volume: 42, Issue:Pt 6

    Topics: 5,10-Methylenetetrahydrofolate Reductase (FADH2); Coronary Artery Disease; Cystathionine beta-Synthase; Environment; Erythrocytes; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Polymorphism, Genetic; Risk Factors; Vitamin B 12; Vitamin B 6

2005
Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population.
    Thrombosis and haemostasis, 2005, Volume: 94, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Alleles; Case-Control Studies; Coronary Artery Disease; Female; Ferredoxin-NADP Reductase; Folic Acid; France; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Transcobalamins; Vitamin B 12; White People

2005
Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2005, Volume: 14, Issue:11 Pt 1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adenoma; Adult; Aged; Case-Control Studies; Colonic Neoplasms; Diet; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Membrane Transport Proteins; Middle Aged; Odds Ratio; Polymorphism, Genetic; Reduced Folate Carrier Protein; Thymidylate Synthase

2005
Methylenetetrahydrofolate reductase 677C>T polymorphism and gastric cancer susceptibility in Mexico.
    European journal of cancer (Oxford, England : 1990), 2006, Volume: 42, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Alcohol Drinking; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Middle Aged; Polymorphism, Genetic; Risk Factors; Stomach Neoplasms

2006
Reversible nitrous oxide myelopathy and a polymorphism in the gene encoding 5,10-methylenetetrahydrofolate reductase.
    British journal of anaesthesia, 2006, Volume: 96, Issue:2

    Topics: Anesthetics, Inhalation; Folic Acid; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Nitrous Oxide; Paralysis; Polymorphism, Genetic; Postoperative Complications; Spinal Cord Diseases; Vitamin B 12

2006
Implication of the folate-methionine metabolism pathways in susceptibility to follicular lymphomas.
    Blood, 2006, Jul-01, Volume: 108, Issue:1

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; DNA; Enzymes; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Humans; Lymphoma, Follicular; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Polymorphism, Genetic; Risk Factors; Thymidylate Synthase

2006
Relationship between nutritional habits adopted by ulcerative colitis relevant to cancer development patients at clinical remission stages and molecular-genetic parameters.
    The British journal of nutrition, 2006, Volume: 95, Issue:1

    Topics: Adult; Aged; Aneuploidy; Ascorbic Acid; Calcium, Dietary; Chromosomes, Human, Pair 17; Colitis, Ulcerative; Colon; Colorectal Neoplasms; Dietary Fats; Dietary Fiber; Energy Intake; Fabaceae; Feeding Behavior; Female; Folic Acid; Genetic Predisposition to Disease; Humans; In Situ Hybridization, Fluorescence; Male; Middle Aged; Nutritional Status; Risk Factors; Vitamin A

2006
Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate.
    Human mutation, 2006, Volume: 27, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Alleles; Cleft Lip; Cleft Palate; Ferredoxin-NADP Reductase; Folic Acid; Gene Expression Regulation; Genetic Markers; Genetic Predisposition to Disease; Humans; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Transcobalamins

2006
Heterogeneity of association between MTHFR and stroke among European regions: additional population studies are needed in Italy.
    Stroke, 2006, Volume: 37, Issue:3

    Topics: Aged; Alleles; Aortic Dissection; Brain Ischemia; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genetics, Population; Genotype; Humans; Italy; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Multivariate Analysis; Odds Ratio; Phenotype; Polymorphism, Genetic; Sex Factors; Stroke; Time Factors

2006
Factor V Leiden, pregnancy complications and adverse outcomes: the Hordaland Homocysteine Study.
    QJM : monthly journal of the Association of Physicians, 2006, Volume: 99, Issue:5

    Topics: Adult; Factor V; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Maternal Age; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Norway; Odds Ratio; Polymorphism, Genetic; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Retrospective Studies; Risk Factors; Smoking; Vitamin B 12

2006
Polymorphisms in genes involved in folate metabolism as risk factors for oedematous severe childhood malnutrition: a hypothesis-generating study.
    Annals of tropical paediatrics, 2006, Volume: 26, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Case-Control Studies; Child; Child, Preschool; Cystathionine beta-Synthase; Edema; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Malnutrition; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Polymorphism, Genetic

2006
Polymorphisms in thymidylate synthase gene and susceptibility to breast cancer in a Chinese population: a case-control analysis.
    BMC cancer, 2006, May-25, Volume: 6

    Topics: 3' Untranslated Regions; 5' Untranslated Regions; Adult; Aged; Breast Neoplasms; Case-Control Studies; China; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Middle Aged; Mutagenesis, Insertional; Polymorphism, Genetic; Postmenopause; Reproductive History; Sequence Deletion; Tandem Repeat Sequences; Thymidine; Thymidylate Synthase

2006
Genetic polymorphisms of the methylenetetrahydrofolate reductase gene, plasma folate levels and breast cancer susceptibility: a case-control study in Taiwan.
    Carcinogenesis, 2006, Volume: 27, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Radioimmunoassay; Risk; Taiwan

2006
Genetic polymorphism of folate and methionine metabolizing enzymes and their susceptibility to malignant lymphoma.
    Journal of the Egyptian National Cancer Institute, 2005, Volume: 17, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Child; Child, Preschool; DNA Methylation; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Lymphoma; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic

2005
Association study of four polymorphisms in three folate-related enzyme genes with non-obstructive male infertility.
    Human reproduction (Oxford, England), 2006, Volume: 21, Issue:12

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Infertility, Male; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide

2006
The methylenetetrahydrofolate reductase C677T gene mutation is associated with hyperhomocysteinemia, cardiovascular disease and plasma B-type natriuretic peptide levels in Korea.
    Clinical chemistry and laboratory medicine, 2006, Volume: 44, Issue:9

    Topics: Aged; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Creatine Kinase; Creatinine; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Isoenzymes; Korea; L-Lactate Dehydrogenase; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Natriuretic Peptide, Brain; Troponin I

2006
Association of homocysteine, vitamin B12, folic acid, and MTHFR C677T in patients with a thrombotic event or recurrent fetal loss.
    Annals of hematology, 2007, Volume: 86, Issue:1

    Topics: Abortion, Habitual; Adolescent; Adult; Aged; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Pregnancy; Risk Factors; Thrombosis; Vitamin B 12

2007
Polymorphisms in folate metabolizing genes and risk for spontaneous preterm and small-for-gestational age birth.
    American journal of obstetrics and gynecology, 2006, Volume: 195, Issue:5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Black People; Case-Control Studies; Diet; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Glycine Hydroxymethyltransferase; Heterozygote; Humans; Infant, Newborn; Infant, Small for Gestational Age; Methylenetetrahydrofolate Reductase (NADPH2); Pregnancy; Premature Birth; White People

2006
The folate metabolic enzyme ALDH1L1 is restricted to the midline of the early CNS, suggesting a role in human neural tube defects.
    The Journal of comparative neurology, 2007, Jan-10, Volume: 500, Issue:2

    Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase 1 Family; Animals; Cell Differentiation; Cell Proliferation; Central Nervous System; Disease Models, Animal; Female; Folic Acid; Gene Expression Regulation, Developmental; Genetic Predisposition to Disease; Humans; Isoenzymes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mutation; Neural Tube Defects; Neuroglia; Neurons; Paired Box Transcription Factors; PAX3 Transcription Factor; Retinal Dehydrogenase; Stem Cells; Up-Regulation

2007
Susceptibility groups for Alzheimer's disease (OPTIMA cohort): integration of gene variants and biochemical factors.
    Mechanisms of ageing and development, 2007, Volume: 128, Issue:1

    Topics: Aged; Alzheimer Disease; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Male; Vitamin B 12

2007
The methionine synthase polymorphism c.2756A>G alters susceptibility to glioblastoma multiforme.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2006, Volume: 15, Issue:11

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Alleles; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Glioblastoma; Humans; Male; Middle Aged; Mutation, Missense; Polymorphism, Genetic; Vitamin B 12

2006
Plasma vitamin values and antiepileptic therapy: case reports of pregnancy outcomes affected by a neural tube defect.
    Birth defects research. Part A, Clinical and molecular teratology, 2007, Volume: 79, Issue:1

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Neural Tube Defects; Pregnancy; Pregnancy Complications; Pregnancy Outcome; Valproic Acid; Vitamin B 12; Vitamin B 6

2007
Infant C677T MTHFR polymorphism and severe mental retardation.
    Birth defects research. Part A, Clinical and molecular teratology, 2007, Volume: 79, Issue:1

    Topics: Alleles; Congenital Abnormalities; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homozygote; Humans; Infant; Infant, Newborn; Intellectual Disability; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk Factors

2007
Gene polymorphisms of folate metabolizing enzymes and the risk of gastric cancer.
    Cancer letters, 2007, Jun-28, Volume: 251, Issue:2

    Topics: Aged; Carboxypeptidases; Case-Control Studies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk Factors; Stomach Neoplasms; Vitamin B 12

2007
Fetal and maternal MTHFR C677T genotype, maternal folate intake and the risk of nonsyndromic oral clefts.
    American journal of medical genetics. Part A, 2007, Feb-01, Volume: 143A, Issue:3

    Topics: Case-Control Studies; Cleft Lip; Cleft Palate; Diet; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Maternal Nutritional Physiological Phenomena; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Genetic; Pregnancy

2007
Genetic polymorphisms in folate metabolism and the risk of stomach cancer.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Volume: 16, Issue:1

    Topics: Adult; Aged; Case-Control Studies; DNA Methylation; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Genetic; Risk Factors; Stomach Neoplasms

2007
Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer.
    Cancer causes & control : CCC, 2007, Volume: 18, Issue:2

    Topics: Adult; Aged; Alcohol Drinking; California; Case-Control Studies; Diet; Diet Surveys; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Male; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Rectal Neoplasms; Riboflavin; Risk; Utah; Vitamin B 12; Vitamin B 6

2007
Functional COMT Val158Met polymorphism, risk of acute coronary events and serum homocysteine: the Kuopio ischaemic heart disease risk factor study.
    PloS one, 2007, Jan-31, Volume: 2, Issue:1

    Topics: Adult; Catechol O-Methyltransferase; Cohort Studies; Coronary Disease; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Ischemia; Polymorphism, Genetic; Prospective Studies; Risk Factors

2007
Associations of MTHFR DNMT3b 4977 bp deletion in mtDNA and GSTM1 deletion, and aberrant CpG island hypermethylation of GSTM1 in non-obstructive infertility in Indian men.
    Molecular human reproduction, 2007, Volume: 13, Issue:4

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Adult; Base Sequence; Case-Control Studies; CpG Islands; Deoxyguanosine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; DNA, Mitochondrial; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Glutathione Transferase; Homocysteine; Humans; India; Infertility, Male; Male; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Risk Factors; Sequence Deletion; Vitamin B 12; White People

2007
Dietary folate intake in combination with MTHFR C677T genotype and promoter methylation of tumor suppressor and DNA repair genes in sporadic colorectal adenomas.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2007, Volume: 16, Issue:2

    Topics: Adenoma; Adolescent; Adult; Aged; Case-Control Studies; Colorectal Neoplasms; DNA Methylation; DNA Repair; Female; Folic Acid; Genes, Tumor Suppressor; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Netherlands; Polymerase Chain Reaction; Promoter Regions, Genetic; Surveys and Questionnaires

2007
MTHFR C677T has differential influence on risk of MSI and MSS colorectal cancer.
    Human molecular genetics, 2007, May-01, Volume: 16, Issue:9

    Topics: Adult; Aged; Colorectal Neoplasms; DNA Methylation; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genomic Instability; Genotype; Germ-Line Mutation; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Microsatellite Repeats; Middle Aged; Phenotype; Polymorphism, Single Nucleotide

2007
Folate-related genes and the risk of tobacco-related cancers in Central Europe.
    Carcinogenesis, 2007, Volume: 28, Issue:6

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Case-Control Studies; Europe; Folic Acid; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neoplasms; Nicotiana; Polymorphism, Single Nucleotide; Risk Factors

2007
Associations of common polymorphisms in the thymidylate synthase, reduced folate carrier and 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase genes with folate and homocysteine levels and venous thrombosis
    Clinical chemistry and laboratory medicine, 2007, Volume: 45, Issue:4

    Topics: Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hydroxymethyl and Formyl Transferases; Membrane Transport Proteins; Multienzyme Complexes; Nucleotide Deaminases; Polymorphism, Genetic; Reduced Folate Carrier Protein; Thymidylate Synthase; Venous Thrombosis

2007
[Correlation between serum homocysteine levels and selected atherosclerosis risk factors in children and adolescents with simple obesity].
    Przeglad lekarski, 2006, Volume: 63, Issue:8

    Topics: Adolescent; Atherosclerosis; Biomarkers; Body Mass Index; Child; Comorbidity; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hypertension; Male; Obesity; Obesity, Morbid; Poland; Risk Factors; Statistics, Nonparametric; Vitamin B 12

2006
Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study.
    Carcinogenesis, 2007, Volume: 28, Issue:8

    Topics: Adenocarcinoma; Adolescent; Adult; Aged; Carcinoma, Large Cell; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Japan; Lung Neoplasms; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Random Allocation; Risk Factors

2007
Polymorphisms involved in the folate metabolizing pathway and risk of multiple myeloma.
    American journal of hematology, 2007, Volume: 82, Issue:9

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genetic Variation; Humans; Korea; Male; Middle Aged; Multiple Myeloma; Odds Ratio; Polymorphism, Genetic; Risk Factors

2007
One-carbon metabolism-related gene polymorphisms and risk of head and neck squamous cell carcinoma: case-control study.
    Cancer science, 2007, Volume: 98, Issue:9

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Alcohol Drinking; Carbon; Carcinoma, Squamous Cell; Case-Control Studies; Diet; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Head and Neck Neoplasms; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Random Allocation; Risk Factors; Thymidylate Synthase

2007
Mild hyperhomocysteinemia and low folate concentrations as risk factors for cervical arterial dissection.
    Cerebrovascular diseases (Basel, Switzerland), 2007, Volume: 24, Issue:2-3

    Topics: Adolescent; Adult; Carotid Artery, Internal, Dissection; Case-Control Studies; Cerebral Arteries; Cerebral Infarction; Fasting; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Male; Methylenetetrahydrofolate Reductase (NADPH2); Mexico; Middle Aged; Nutritional Status; Odds Ratio; Polymorphism, Genetic; Prospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Vertebral Artery Dissection; Vitamin B 12

2007
Associations between 2 polymorphisms in the methylenetetrahydrofolate reductase gene and placental abruption.
    American journal of obstetrics and gynecology, 2007, Volume: 197, Issue:4

    Topics: Abruptio Placentae; Adolescent; Adult; Alleles; Case-Control Studies; DNA; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Linkage Disequilibrium; Methylenetetrahydrofolate Reductase (NADPH2); Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Pregnancy; Social Class; Vitamin B 12

2007
[The relationship between polymorphism of gene involved in folate metabolism, homocysteine level and risk of Down syndrome].
    Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics, 2007, Volume: 24, Issue:5

    Topics: Adult; Alleles; Base Sequence; Case-Control Studies; Down Syndrome; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Polymorphism, Genetic; Pregnancy

2007
Association between polymorphisms of folate-metabolizing enzymes and risk of prostate cancer.
    European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, 2008, Volume: 34, Issue:7

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Case-Control Studies; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Male; Methylenetetrahydrofolate Reductase (NADPH2); Multivariate Analysis; Polymorphism, Genetic; Prostatic Hyperplasia; Prostatic Neoplasms; Spain

2008
Association between folate-metabolizing pathway polymorphism and non-Hodgkin lymphoma.
    British journal of haematology, 2008, Volume: 140, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Haplotypes; Humans; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Odds Ratio; Polymorphism, Genetic; Risk; Thymidylate Synthase

2008
Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake.
    The British journal of nutrition, 2008, Volume: 99, Issue:2

    Topics: Adult; Case-Control Studies; Colorectal Neoplasms; Diet; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Risk Factors; Vitamin B 12; Vitamin B 6

2008
Distinct association of SLC19A1 polymorphism -43T>C with red cell folate levels and of MTHFR polymorphism 677C>T with plasma folate levels.
    Clinical biochemistry, 2008, Volume: 41, Issue:3

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Biomarkers; Coronary Artery Disease; Erythrocytes; Female; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Male; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Serum

2008
MTHFR genetic polymorphism as a risk factor in Egyptian mothers with Down syndrome children.
    Disease markers, 2008, Volume: 24, Issue:1

    Topics: Adult; Diet; Down Syndrome; Egypt; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Pilot Projects; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length

2008
One-carbon metabolism-related gene polymorphisms and risk of breast cancer.
    Carcinogenesis, 2008, Volume: 29, Issue:2

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Breast Neoplasms; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Japan; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Thymidylate Synthase

2008
Methylenetetrahydrofolate reductase 677 T allele protects against persistent HBV infection in West Africa.
    Journal of hepatology, 2008, Volume: 48, Issue:4

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Alleles; Benin; Biomarkers; DNA; DNA Probes; DNA, Viral; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B virus; HLA-DR Antigens; HLA-DRB1 Chains; Homocysteine; Humans; Immunoassay; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Morbidity; Polymerase Chain Reaction; Polymorphism, Genetic; Vitamin B 12

2008
Role of methylenetetrahydrofolate reductase 677C->T polymorphism in the development of premature myocardial infarction.
    Atherosclerosis, 2008, Volume: 200, Issue:1

    Topics: Adult; Case-Control Studies; Coronary Angiography; Coronary Vessels; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Myocardial Infarction; Odds Ratio; Polymorphism, Single Nucleotide

2008
Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome in China.
    Journal of Zhejiang University. Science. B, 2008, Volume: 9, Issue:2

    Topics: Alleles; Case-Control Studies; China; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homozygote; Humans; Lymphocytes; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Risk Factors

2008
Association of RFC1 A80G and MTHFR C677T polymorphisms with Alzheimer's disease.
    Neurobiology of aging, 2009, Volume: 30, Issue:10

    Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Apolipoprotein E4; China; Female; Folic Acid; Genetic Predisposition to Disease; Genome-Wide Association Study; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Reduced Folate Carrier Protein; Risk Factors; Sex Factors

2009
Protective effect against alcohol dependence of the thermolabile variant of MTHFR.
    Drug and alcohol dependence, 2008, Jul-01, Volume: 96, Issue:1-2

    Topics: Alcohol Drinking; Alcoholic Neuropathy; Alcoholism; Control Groups; Female; Folic Acid; Folic Acid Deficiency; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Liver Diseases, Alcoholic; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Genetic; Risk; Vitamin B 12

2008
Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms.
    Circulation, 2008, Apr-08, Volume: 117, Issue:14

    Topics: Aged; Aged, 80 and over; Boston; Cardiotonic Agents; Case-Control Studies; Diet; Folic Acid; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Heart Conduction System; Heart Rate; Humans; Male; Meteorological Concepts; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Particulate Matter; Polymorphism, Single Nucleotide; Risk Factors; Vitamin B Complex

2008
Polymorphisms in genes related to folate and cobalamin metabolism and the associations with complex birth defects.
    Prenatal diagnosis, 2008, Volume: 28, Issue:6

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Amniotic Fluid; Case-Control Studies; Child; Congenital Abnormalities; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Genetic; Pregnancy; Risk Factors; Transcobalamins; Vitamin B 12

2008
Systemic folate status and risk of colorectal cancer.
    Cancer causes & control : CCC, 2008, Volume: 19, Issue:9

    Topics: Colorectal Neoplasms; Folic Acid; Folic Acid Deficiency; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Polymorphism, Single Nucleotide; Risk

2008
Thymidylate synthase genotype and serum concentrations of homocysteine and folate in Behçet's disease.
    Clinical rheumatology, 2008, Volume: 27, Issue:10

    Topics: Adolescent; Adult; Behcet Syndrome; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Middle Aged; Promoter Regions, Genetic; Tandem Repeat Sequences; Thymidylate Synthase; Venous Thrombosis; Young Adult

2008
Cryptogenic stroke in a boy with atrial septal defect and hyperhomocysteinemia.
    Journal of child neurology, 2008, Volume: 23, Issue:9

    Topics: Adolescent; Age of Onset; Anticoagulants; Blood Coagulation Disorders, Inherited; Cerebral Arteries; Diffusion Magnetic Resonance Imaging; Folic Acid; Genetic Predisposition to Disease; Heart Septal Defects, Atrial; Hemianopsia; Humans; Hyperhomocysteinemia; Infarction, Posterior Cerebral Artery; Intracranial Embolism; Male; Occipital Lobe; Stroke; Vitamin B 12

2008
Functional polymorphisms in folate metabolism genes influence the risk of meningioma and glioma.
    Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2008, Volume: 17, Issue:5

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Brain Neoplasms; Case-Control Studies; Female; Ferredoxin-NADP Reductase; Folic Acid; Genetic Predisposition to Disease; Genotype; Glioma; Humans; Male; Meningeal Neoplasms; Meningioma; Methylenetetrahydrofolate Dehydrogenase (NADP); Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Polymorphism, Single Nucleotide; Risk

2008
Genetic effects on variation in red-blood-cell folate in adults: implications for the familial aggregation of neural tube defects.
    American journal of human genetics, 1997, Volume: 60, Issue:2

    Topics: Adult; Age Factors; Blood Specimen Collection; Erythrocytes; Female; Folic Acid; Genetic Predisposition to Disease; Humans; Likelihood Functions; Male; Models, Genetic; Models, Statistical; Neural Tube Defects; Odds Ratio; Risk Factors; Sex Characteristics; Statistics, Nonparametric; Twins, Dizygotic; Twins, Monozygotic

1997
[A young patient with chronic recurrent leg ulcers; hyperhomocysteinemia and heterozygote for factor V Leiden].
    Nederlands tijdschrift voor geneeskunde, 1998, Dec-05, Volume: 142, Issue:49

    Topics: Adult; Anticoagulants; Bandages; Chronic Disease; Factor V; Folic Acid; Genetic Carrier Screening; Genetic Predisposition to Disease; Homocysteine; Humans; Leg Ulcer; Male; Metabolism, Inborn Errors; Secondary Prevention; Venous Thrombosis

1998
Homocysteine and arteriosclerosis: subclinical and clinical disease associations.
    Circulation, 1999, May-11, Volume: 99, Issue:18

    Topics: Adolescent; Adult; Animals; Arteriosclerosis; Child; Child, Preschool; Comorbidity; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Homocystinuria; Humans; Hyperhomocysteinemia; Middle Aged; Prevalence; Primates; Risk Factors; Swine; Swine, Miniature; Thrombophilia

1999
Hyperhomocysteinemia but not the C677T mutation of methylenetetrahydrofolate reductase is an independent risk determinant of carotid wall thickening. The Perth Carotid Ultrasound Disease Assessment Study (CUDAS)
    Circulation, 1999, May-11, Volume: 99, Issue:18

    Topics: Adult; Aged; Amino Acid Substitution; Arteriosclerosis; Carotid Arteries; Carotid Stenosis; Comorbidity; Diet; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Health Surveys; Homocysteine; Humans; Hyperhomocysteinemia; Hyperlipidemias; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation, Missense; Obesity; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Pyridoxine; Risk Factors; Smoking; Tunica Intima; Ultrasonography; Vitamin B 12; Western Australia

1999
Determinants of fasting and post-methionine homocysteine levels in families predisposed to hyperhomocysteinemia and premature vascular disease.
    Arteriosclerosis, thrombosis, and vascular biology, 1999, Volume: 19, Issue:5

    Topics: Adult; Age Factors; Amino Acid Substitution; Arteriosclerosis; Body Mass Index; Comorbidity; Fasting; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Hyperhomocysteinemia; Hypertension; Lipids; Male; Menopause; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pyridoxine; Smoking; Vitamin B 12

1999
Methylenetetrahydrofolate reductase genotypes and early-onset coronary artery disease.
    Circulation, 1999, Dec-14, Volume: 100, Issue:24

    Topics: Age of Onset; Alleles; Coronary Disease; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homozygote; Humans; Israel; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Myocardial Infarction; Oxidoreductases Acting on CH-NH Group Donors; Prevalence; Risk Factors

1999
Methylenetetrahydrofolate reductase 677 C --> T polymorphism, plasma folate, vitamin B(12) concentrations, and risk of preeclampsia among black African women from Zimbabwe.
    Molecular genetics and metabolism, 2000, Volume: 69, Issue:1

    Topics: Adolescent; Adult; Alleles; Black People; Case-Control Studies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Nutritional Physiological Phenomena; Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Risk Factors; Vitamin B 12; Zimbabwe

2000
Children with stroke: polymorphism of the MTHFR gene, mild hyperhomocysteinemia, and vitamin status.
    Journal of child neurology, 2000, Volume: 15, Issue:5

    Topics: Adolescent; Case-Control Studies; Child; Child, Preschool; Cytosine; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Hyperhomocysteinemia; Infant; Male; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Point Mutation; Polymorphism, Genetic; Pyridoxine; Secondary Prevention; Stroke; Thymidine; Vitamin B 12; Vitamins

2000
Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome.
    American journal of human genetics, 2000, Volume: 67, Issue:3

    Topics: Adult; Alleles; Case-Control Studies; DNA Mutational Analysis; Down Syndrome; Female; Ferredoxin-NADP Reductase; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Odds Ratio; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy

2000
The association between two common mutations C677T and A1298C in human methylenetetrahydrofolate reductase gene and the risk for diabetic nephropathy in type II diabetic patients.
    The Journal of nutrition, 2000, Volume: 130, Issue:10

    Topics: Aged; Albuminuria; Alleles; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors

2000
The influence of age, sex, vitamin B(12), folate levels and methylenetetrahydrofolate reductase C677T genetic mutations on plasma homocysteine in the Chinese population.
    Haematologica, 2000, Volume: 85, Issue:10

    Topics: Age Factors; Aged; China; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Sex Factors; Thromboembolism; Vitamin B 12

2000
Effects of dietary folate on intestinal tumorigenesis in the apcMin mouse.
    Cancer research, 2000, Oct-01, Volume: 60, Issue:19

    Topics: Adenoma; Animals; Anticarcinogenic Agents; Body Weight; Colonic Neoplasms; Diet; Female; Folic Acid; Genes, APC; Genetic Predisposition to Disease; Intestinal Neoplasms; Intestinal Polyps; Intestine, Small; Male; Mice; Mice, Inbred C57BL; Precancerous Conditions

2000
Effect of heterozygosity for the methionine synthase 2756 A-->G mutation on the risk for recurrent cardiovascular events.
    The American journal of cardiology, 2000, Nov-15, Volume: 86, Issue:10

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Aged; Disease-Free Survival; Erythrocytes; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Heterozygote; Homocysteine; Humans; Incidence; Male; Middle Aged; Mutation; Myocardial Infarction; Polymorphism, Genetic; Predictive Value of Tests; Proportional Hazards Models; Prospective Studies; Recurrence; Risk Factors

2000
Genetic basis of susceptibility to environmentally induced neural tube defects.
    Annals of the New York Academy of Sciences, 2000, Volume: 919

    Topics: Animals; Carrier Proteins; Cell Cycle; Disease Models, Animal; DNA Fingerprinting; Embryonic and Fetal Development; Environmental Pollutants; Folate Receptors, GPI-Anchored; Folic Acid; Genetic Predisposition to Disease; Gestational Age; Growth Substances; Humans; Hyperthermia, Induced; Mice; Mice, Knockout; Neural Tube Defects; Polymorphism, Single-Stranded Conformational; Receptors, Cell Surface; Valproic Acid

2000
Methylenetetrahydrofolate reductase genotypes and predisposition to atherothrombotic disease; evidence that all three MTHFR C677T genotypes confer different levels of risk.
    European heart journal, 2001, Volume: 22, Issue:4

    Topics: Coronary Artery Disease; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Mutation; Oxidoreductases Acting on CH-NH Group Donors

2001
Racial variation in fasting and random homocysteine levels.
    American journal of hematology, 2001, Volume: 66, Issue:4

    Topics: Black People; Blood Urea Nitrogen; Body Mass Index; Creatinine; Fasting; Female; Folic Acid; Genetic Predisposition to Disease; Homocysteine; Humans; Hyperhomocysteinemia; Lipids; Male; New York City; Personnel, Hospital; Random Allocation; Reference Values; Time Factors; Vitamin B 12; White People

2001
Association between polymorphisms of folate- and methionine-metabolizing enzymes and susceptibility to malignant lymphoma.
    Blood, 2001, May-15, Volume: 97, Issue:10

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adult; Aged; Aged, 80 and over; Case-Control Studies; DNA; DNA Methylation; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Lymphoma; Methionine; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic

2001
Mutation A1298C of methylenetetrahydrofolate reductase: risk for early coronary disease not associated with hyperhomocysteinemia.
    American journal of medical genetics, 2001, Jun-01, Volume: 101, Issue:1

    Topics: Adolescent; Adult; Age of Onset; Alleles; Case-Control Studies; Coronary Disease; Female; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Genotype; Homocysteine; Homozygote; Humans; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Myocardial Infarction; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Prevalence; Risk Factors

2001
Maternal folate polymorphisms and the etiology of human nondisjunction.
    American journal of human genetics, 2001, Volume: 69, Issue:2

    Topics: Case-Control Studies; Chromosomes, Human, Pair 18; DNA Mutational Analysis; England; Female; Ferredoxin-NADP Reductase; Fetal Diseases; Folic Acid; Gene Frequency; Genetic Predisposition to Disease; Humans; Meiosis; Methylenetetrahydrofolate Reductase (NADPH2); Molecular Sequence Data; Nondisjunction, Genetic; Ohio; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Pregnancy; Sex Chromosome Aberrations; Trisomy

2001
Assessment of prothrombotic risk in patients with Behçet's disease should include homocysteine plasma levels.
    The Journal of rheumatology, 2001, Volume: 28, Issue:12

    Topics: Behcet Syndrome; Folic Acid; Genetic Predisposition to Disease; Genotype; Homocysteine; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Risk Factors; Thromboembolism; Vitamin B 12; Vitamin B 6

2001
Thromboplastin-thrombomodulin-mediated time and serum folate levels are genetically correlated with the risk of thromboembolic disease: results from the GAIT project.
    Thrombosis and haemostasis, 2002, Volume: 87, Issue:1

    Topics: Adult; alpha-2-Antiplasmin; beta 2-Glycoprotein I; Blood Coagulation Tests; Comorbidity; Contraceptives, Oral, Hormonal; Factor XIII; Female; Folic Acid; Genetic Predisposition to Disease; Glycoproteins; Humans; Male; Middle Aged; P-Selectin; Phenotype; Risk Factors; Smoking; Spain; Thrombomodulin; Thrombophilia; Thromboplastin; Vitamin B 12

2002
Maternal periconceptional vitamin use, genetic variation of infant reduced folate carrier (A80G), and risk of spina bifida.
    American journal of medical genetics, 2002, Feb-15, Volume: 108, Issue:1

    Topics: Amino Acid Substitution; Biological Transport; Carrier Proteins; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Humans; Infant, Newborn; Membrane Proteins; Membrane Transport Proteins; Methylenetetrahydrofolate Reductase (NADPH2); Mutation, Missense; Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Single Nucleotide; Pregnancy; Spinal Dysraphism

2002
Polymorphisms in the thymidylate synthase and serine hydroxymethyltransferase genes and risk of adult acute lymphocytic leukemia.
    Blood, 2002, May-15, Volume: 99, Issue:10

    Topics: 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase; Adolescent; Adult; Aged; Case-Control Studies; Female; Folic Acid; Genetic Predisposition to Disease; Genotype; Glycine Hydroxymethyltransferase; Humans; Male; Middle Aged; Models, Chemical; Multivariate Analysis; Odds Ratio; Polymorphism, Genetic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Thymidylate Synthase

2002
Hyperhomocysteinemia, MTHFR 677C-->T polymorphism, and stroke.
    Stroke, 2002, Volume: 33, Issue:6

    Topics: Adult; Folic Acid; Food, Fortified; Genetic Predisposition to Disease; Humans; Hyperhomocysteinemia; Methylenetetrahydrofolate Reductase (NADPH2); Oxidoreductases Acting on CH-NH Group Donors; Polymorphism, Genetic; Predictive Value of Tests; Risk; Sample Size; Sensitivity and Specificity; Stroke

2002
By the way doctor. I've heard a lot about what I should do during pregnancy to have a healthy baby, but I'd like to know what I can do now, before I become pregnant.
    Harvard women's health watch, 2002, Volume: 9, Issue:10

    Topics: Female; Folic Acid; Genetic Predisposition to Disease; Humans; Nutritional Physiological Phenomena; Polypharmacy; Preconception Care; Pregnancy; Vitamins

2002
No difference in expression of chromosomal fragile sites in patients with solid malignant tumours and normal controls.
    Genes, chromosomes & cancer, 1990, Volume: 2, Issue:1

    Topics: Chromosome Fragile Sites; Chromosome Fragility; Chromosomes, Human; Folic Acid; Genetic Predisposition to Disease; Humans; Lymphocytes; Neoplasms; Single-Blind Method

1990